\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 179 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 252 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\n'}],latestNews:[{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"}]},book:{item:{type:"book",id:"3205",leadTitle:null,fullTitle:"Design of Experiments - Applications",title:"Design of Experiments",subtitle:"Applications",reviewType:"peer-reviewed",abstract:"This book is a research publication that covers original research on developments within the Design of Experiments - Applications field of study. 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He graduated in Animal Husbandry from University of Agriculture, Faisalabad in 1982. He earned his Master’s and Doctorate degrees in Animal Breeding and Genetics from University of Agriculture, Faisalabad. He joined Government of Punjab, Livestock and Dairy Development as Veterinary Officer in 1983 and remained engaged in research in different capacities. Dr. Khalid conducted research, trainings and teaching in the fields of Animal Breeding, Population/Quantitative Genetics, and Statistical Genetics. He analyzed the production data of various livestock species (e.g., cattle, buffalo, sheep, goats, chicken) to characterize the phenotypic and genetic structure related to different traits of economic importance and subsequent selection. Moreover, he has been engaged in inter-disciplinary collaborative research with colleagues from various academic and research institutes to study the genetic, breeding, management and environmental factors affecting productivity of livestock species. He joined University of Veterinary and Animal Sciences during 2003 as Assistant Professor where he was later selected and appointed as Associate Professor and Professor, in 2006 and 2011 respectively. His research focus is on selection and breeding of large and small ruminants. He also supervises and evaluates postgraduate research to ensure successful and timely completion of the projects focusing on genetic improvement, enhancing breeding efficiency and production enhancement of farm animals. In addition, he participates and conducts trainings, workshops, conferences and seminars, and writes scientific publications to disseminate knowledge and techniques to the researchers and livestock producers about various areas of animal husbandry for improving behaviour, health, growth, fertility and production of livestock. He has more than 200 publications/research articles published and is working as Senior Editor of an internationally recognized Journal of Animal and Plant Sciences-JAPS.",institutionString:"University of Veterinary and Animal Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Veterinary and Animal Sciences",institutionURL:null,country:{name:"Pakistan"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"326",title:"Food Industry",slug:"food-industry"}],chapters:[{id:"65652",title:"Current Standing and Future Challenges of Dairying in Pakistan: A Status Update",slug:"current-standing-and-future-challenges-of-dairying-in-pakistan-a-status-update",totalDownloads:1359,totalCrossrefCites:0,authors:[{id:"270832",title:"Dr.",name:"Muhammad Naeem",surname:"Tahir",slug:"muhammad-naeem-tahir",fullName:"Muhammad Naeem 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Various metal nutrients supplied by food contributed to maintain metabolism normally. Unfortunately, iron (Fe) and zinc (Zn), as the most important metal elements, are present in low quantities of staple food, such as rice and wheat [1]. What is worse is that, in some parts of Africa and Asia, people even cannot afford enough food for their kids and families. Fe deficiency is one of the leading risk factors of disability and death worldwide. It is estimated to affect two billion people in the world [2]. Also, it has been estimated that about 30% population of the world suffers from Zn deficiency [3]. Fe-deficiency anemia can impair cognitive and physical development in children and the reduction of daily productivity in adults. Adequate Zn nutrition is also important for the growth of children, immune function, and neurobehavioral development [4]. Thus, Fe and Zn deficiency has emerged as a major and common problem for the health of humans [5, 6].
\nRice is the staple food and provides energy to almost half of the world’s population, especially in Asia and Africa. Thus, increasing Fe/Zn content of rice has a great potential to mitigate widespread Fe/Zn deficiency problem in humans [7]. Therefore, it is essential to understand the mechanisms through which rice uptakes, mobilizes, and accumulates Fe/Zn. In response to Fe deficiency, higher plants have developed two strategies for acquiring Fe from the rhizosphere [8, 9]. Strategy I is employed in nongraminaceous plants, and Fe(III) is reduced to soluble Fe(II) through activating membrane-bound Fe(III)-chelate reductases, then the reduced Fe(II) was transported into cytoplasm via Fe(II) transporters [10]. In contrast, Strategy II is only applied by graminaceous plants, such as rice and wheat. The root of strategy II plants secretes phytosiderophores (PSs) to rhizosphere and chelates Fe(III) to form Fe(III)-PS complexes. Subsequently, the Fe(III)-PS complexes are transported via specific plasma membrane transporters [7]. Rice not only employs strategy II to acquire Fe from rhizosphere but also utilizes strategy I-like system to uptake Fe(II) directly [10]. Besides Fe uptake, mugineic acid (MA) family also plays crucial roles in chelating Zn from rhizosphere, followed by uptake of Zn-PS complexes via specific plasma membrane transporters [7]. Moreover, Zn can be ionized as Zn(II) and directly enters into root [11]. In spite of rice can apply specific strategies to acquire Fe and Zn, these mechanisms have limited accessibility to resource poor people faced with Fe and Zn deficiency from certain areas of the world. To deal with limited Fe/Zn and improve human Fe/Zn nutritional status, rice with enhanced Fe/Zn absorption will be an effective method for populations consuming rice as their staple foods.
\nBesides necessary metal elements, such as Fe and Zn, rice also absorbs and accumulates toxic metals such as cadmium (Cd) and lead (Pb), which are harmful for both rice and humans. Cd enters into environment, such as soil and river, mainly through industrial activities or fertilizers [12]. As a highly mobile and soluble metal [13, 14], Cd exposure causes crops yield reduction and does harm to humans’ health even at low concentrations [15]. Due to daily consumption, Cd in rice grains poses a latent health problem to humans through food chains and leads to chronic toxicity. The outbreak of “Itai-Itai disease” in the mid-twentieth century in Japan is due to consumption of Cd-contaminated rice [16]. A person with “Itai-Itai” has symptoms of weakness and softening of the bones. Even in recent years, Cd exposure in general Japanese population can be as high as 3–4 mg kg−1 body weight every week [17]. The directly observable toxic symptoms of Cd on plants are as follows: reduced rate of transpiration and photosynthesis, growth retardation and declining metabolic activities [15]. In response to Cd toxicity, plants also have evolved several protective mechanisms against Cd toxicity, including avoidance and tolerance strategies [18]. Plants can prevent Cd from entering into plant cells, which is refered to as avoidance strategy. Cell walls serve as the first barrier against Cd entrance [15, 19]. Root exudates, which are majorly consisted of sugars, proteins and organic acids are secreted from root to soil to combine with Cd, keeping Cd apart from root [20, 21]. After entered into the cells, the abilities of resistance to Cd stress are referred to as tolerance strategy [15]. In rice, phytochelatins (PC) acting as Cd chelator plays a key role in Cd detoxification [22]. PC chelates Cd in the cytosol and forms complexes with Cd. Then the Cd-PCs complexes are sequestered in the vacuoles via specific transporters located at tonoplast [23, 24].
\nPb after arsenic (As) is ranked as the second most harmful element due to its occurrence, toxicity, and exposure potential [25]. Although Pb occurs naturally only in small amounts within the Earth’s crust [26], a large amount of industrial activities are the primary sources of Pb in soil [27]. Pb is released into soil in general forms of Pb(II), lead oxide and lead-metal oxyanion, among which Pb(II) is the most common form [27]. Pb stress can produce reactive oxygen species (ROS) and trigger some antioxidative enzymes, accompanied by the increased level of lipid peroxidation [25, 27]. In rice, Pb toxicity reduces leaf chlorophyll and nitrogen content and increases antioxidative enzymes. Its subsequent translocation to grain causes a great threat to humans’ health [28, 29]. High levels of Pb can cause brain and kidney damage, accompanied with central nervous prostration [27]. Therefore, higher plants possess preventive mechanisms against Pb. Similar to Cd detoxification, cell walls, and compartmentalization in vacuoles have been suggested as an important detoxification mechanism [27].
\nMany researches show that the mechanisms of Fe/Zn/Cd/Pb uptake and accumulation in rice share commons in some aspects as a result of similar entry routes (transporters) within rice cells. However, an increasing number of studies discovered distinct pathways and mechanisms of Fe/Zn/Cd/Pb uptake and accumulation in rice recently. In this chapter, we mainly systematically elaborate and compare physiological and cellular mechanisms of Fe/Zn/Cd/Pb uptake and accumulation in rice. In addition, we also review the mechanisms of maintaining Fe/Zn homeostasis and Cd/Pb detoxification in rice. Effects of fertilizers on Fe/Zn/Cd /Pb accumulation in rice are also discussed. Finally, we enumerate various approaches for reducing grain Cd/Pb accumulation and enhancing Fe/Zn content in rice.
\nMobility and availability of metals from soil are controlled by three following factors: (1) soil conditions (upland or flooded soil, soil solution pH); (2) mineralization (ionization and complex formation); and (3) uptake transporters [11].
\nAlthough Fe in acidic soil is ionized as Fe2+/Fe3+ and easily utilized by plants, Fe in aerobic alkaline soil is immobilized as Fe(OH)3. Rice absorbs Fe3+ via strategy II. In strategy II, S-adenosyl-l-L-methionine (SAM) is catalyzed by nicotianamine synthase (NAS) and produces nicotianamine (NA), which is an intermediate for the biosynthesis of MA family and a vital substance of nicotianamine aminotransferase (NAAT) [6]. Three rice NAS genes, OsNAS1, OsNAS2, and OsNAS3, have been identified to play different roles in Fe uptake and translocation in rice several years ago [30]. NAAT is a critical enzyme converting NA to 2′-deoxymugineic acid (DMA). Six rice NAAT genes (OsNAAT1–6) have been identified, but OsNAAT1 was the only one highly upregulated under Fe deficiency, suggesting that OsNAAT1 rather than OsNAAT2–6 encodes the unique functional enzyme possessing NAAT activity [31]. Cheng et al. [10] demonstrated that NAAT1 mutant was not able to produce DMA and take up Fe(III) efficiently.
\nIn rice, gene that encodes DMA efflux transporters (OsTOM1) is highly expressed under Fe deficiency stress [32]. TOM1 transporter localizes at plasma membrane and mediates DMA secretion to rhizosphere, followed by Fe(III)-DMA complexes formation [32]. Yellow stripe 1 (YS1) gene that encodes Fe(III)-MAs transporters was first acquired in maize [33], and YS1-like (OsYSL) genes in rice have been subsequently identified over decades. OsYSL15 has been demonstrated to be upregulated in rice root and shoot under Fe deficiency to transport Fe(III)-DMA complexes [34]. In addition, OsYSL genes that encode transporters are also involved in Fe translocation within rice [35, 36]. Once transported into cytosol, Fe(III)-DMA is reduced by ascorbate to form Fe(II)-NA [37]. NA is not only an important intermediate for the biosynthesis of MAs but also a significant metal chelator that can take part in translocation of Fe within plants [38]. Fe may be excreted to the xylem in the form of Fe(II)–NA and shift to make complexes predominantly with citrate (Fe2Cit2, Fe3Cit3) and some with DMA [39]. The excretion of citrate from the root cells to the xylem is partly operated by OsFRDL1 (rice ferric reductase defective1-like) to enhance Fe-transport in the xylem as Fe(III)–citrate complexes [40].
\nIn addition to Fe(III)-DMA uptake, rice also absorbs Fe(II) via iron-regulated transporter 1 (OsIRT1) and natural resistance-associated macrophage protein 1 (OsNRAMP1) under flooded conditions [16]. Seven rice NRAMP genes have been identified so far [41]. Recent research indicated that plasma membrane-localized protocatechuic acid (PCA) transporter and phenolic efflux zero1/2 (PEZ1/2) also participated in Fe uptake [42]. Such transporters played a role in absorbing apoplasmic precipitated Fe by secreting phenolics like PCA or caffeic acid. Suppression of PEZ1/2 expression resulted in reduced Fe concentrations [42, 43].
\nZn in both drained and flooded soil is largely ionized as (Zn2+) though some Zn may be bound to organic substances and immobilized as Zn-sulfide (ZnS) in the anaerobic layer [7]. Zn-regulated transporters and iron-regulated transporters like protein (ZIP) family participate in Zn uptake [44]. OsZIP1-8 transporters have been characterized for Zn uptake and translocation in rice [7]. OsZIP1, OsZIP3, and OsZIP4 are required for Zn acquisition from rhizosphere [45]. OsZIP1 and OsZIP3 are mainly located in vascular bundles and epidermal cells, while OsZIP4 is located in apical meristem and phloem cells [45]. Under Zn deficiency stress, expression of OsZIP1, OsZIP3, and OsZIP4 are upregulated [44, 45]. In addition, iron-regulated transporters (OsIRT) are also involved in Zn uptake [11]. OsIRT1 is characterized for Zn uptake in rice besides Fe acquisition [46, 47]. After transported into cytosol, Zn can be sequestered into the vacuoles via transporter OsZIP1 [11]. OsZIP1 is located to tonoplast and mediates influx of Zn into vacuoles [11]. MAs are also characterized for their role in Zn uptake in plants [7].
\nIn comparison with Fe and Zn, Cd in paddy alkaline soil is present in the immobilized forms of CdCO3 and humic acid-bound Cd [48]. Cd is immobilized as Cd-sulfide (CdS) and colloids-bound Cd in flooded soil [49]. Cd in drained acidic soil is ionized as Cd2+, and drainage converts CdS to Cd2+ dramatically, increasing its availability to plants [11]. Cd uptake from rhizosphere is a dose-dependent process and exhibits saturable kinetic characteristics in rice [16, 50]. After analyzing the kinetics of Cd uptake by root in rice, Fujimaki et al. [50] suggested that uptake rate of Cd was proportional to Cd concentration in the culture solution within range from 0.05 to 100 nM, demonstrating a linear relationship between uptake rate and Cd concentration in a certain range. Ishikawa et al. [51] suggested that this kinetic characteristic of Cd uptake could be mediated by transporters. In fact, entrance of Cd into root cells via transporter OsNRAMP5 or OsIRT1 has been proved, and OsNRAMP5 is predominantly applied [52, 53]. OsNRAMP5 expression is identified in root epidermis, exodermis, and outer layers of the cortex as well as in tissues around the xylem [54]. Knockout of OsNRAMP5 reduces Cd accumulation both in straw and grains slightly [4]. Slamet-Loedin et al. [4] also proposed that downregulation of OsNRAMP5 is a preferential strategy to decrease Cd uptake by root. OsNRAMP5 not only mediates Cd uptake but also regulates manganese (Mn) uptake and has relatively a minor effect on Fe uptake under Fe starvation [54]. In addition, higher expression of OsNRAMP1 in root could enhance Cd accumulation in shoot of rice, indicating that OsNRAMP1 was also related with Cd uptake and transport [55].
\nWhen exposed to Cd contamination, rice supplied with Fe3+ generally represents weaker toxic symptoms than rice supplied with Fe2+. The phenomenon is largely attributed to divalent metal transporters that are nonselective for Fe2+ uptake. Rice can uptake either Fe2+ or Cd2+ consequently (Figure 1). In contrast, Fe3+ transporters are selective for Fe3+ with no affinity for other divalent cations, which decreases Cd entrance into rice root to a great extent and reduces Cd toxicity accordingly (Figure 1).
\nSchematic diagram of Fe and Cd uptake mechanisms in rice root. OsNRAMP1 and OsIRT1 can uptake either divalent ion Fe2+ or Cd2+. NA is catalyzed by NAAT1 and finally forms DMA, which is secreted into rhizosphere via transporter OsTOM1 and chelates with Fe3+ to form complex. The complex is transported into cell via transporter OsYSL15.
After influx into cytosol, Cd is sequestered into the vacuoles via transporter OsHMA3 [56] and transiently stored in the form of complexes [15]. This pathway decreases Cd mobility in the cytosol and translocation from root to shoot [15, 57]. Enhancement of OsHMA3 activity has been found to increase storage of Cd in root and decrease the transport of Cd to the shoot and the final accumulation of Cd in rice grains [23]. OsHMA3 is mainly expressed in root [24], and OsHMA3 localized at tonoplast belongs to P1B-ATPases [58]. A high rate of root-to-shoot transport and subsequent accumulation in the grains of 107Cd, which was administered from a culture solution, was observed in OsHMA3-depleted rice lines [51].
\nLead forms various complexes with soil components, and only small parts of the lead present as these complexes in the soil solution are phytoavailable [59]. In soil, Pb may occur as a free metal ion or make complexes with inorganic constituents, such as HCO3−, CO32−, SO42−, and Cl−. Pb also may exist as organic ligands with amino acids, fulvic acids, and humic acids [59]. Lead behavior in soil is mainly controlled by factors, such as pH [60], redox conditions [61], cation-exchange capacity, and organic and inorganic ligand levels [62]. Once adsorbed onto the rhizoderm roots surface, Pb may enter into the root passively, followed by translocating water streams while the mechanism by which Pb enters into root at the molecular level is still unknown. It is suggested that Pb enters into the root through several pathways, and a particular pathway is through ionic channels [59]. Several authors have demonstrated that Ca2+-permeable channels are the main pathway by which Pb enters into root [63, 64]. Ca2+ from rhizosphere will compete with Pb2+ for common uptake position [25].
\nFollowing uptake by root, Fe, Zn and Cd are transported to shoot via xylem and phloem, where a large amount of vascular bundles exist [11]. This radial transport system includes symplasmic and apoplasmic pathways, but the former pathway is predominantly utilized as a result of impediment by Casparian strips occurring in apoplasmic pathway [65]. After Fe(II)-NA formation in the cytosol, Fe(II)-NA is transported to xylem and exchanges NA with citrate, transforming into Fe(III)-citrate preferentially [39, 40]. Fe in the xylem is largely in the form of Fe-citrate and then allocated to all leaves, whereas Fe in the phloem is mainly bound to DMA, citrate, and proteins [11]. The translocation of citrate from root pericycle cells to xylem is mediated by ferric reductase defective 1-like transporter OsFRDL1 [40].
\nTransportation of metals from plant root to shoot requires movement through the xylem [66] and is probably driven by transpiration [67]. Fe, Zn, Pb, and their chemical forms are in rice xylem and phloem saps, and phloem loading is the first step. OsYSL2 plays a role in Fe distribution in the phloem, localizing at the plasma membrane and is responsible for Fe(II)-NA or Mn(II)-NA transport, but not for Fe(III)-DMA transport [68]. Nozoye et al. [32] proposed that the NA efflux transporters (ENA1/2) are responsible for the efflux of NA into xylem or intracellular compartments in order to redistribute Fe. Under Fe deficiency, both OsYSL2 and ENA1 are strongly induced [68, 69]. In addition to transporter OsYSL2, OsYSL15 is considered to transport Fe(III)-DMA for phloem trafficking and expressed in the phloem companion cells [6, 35, 43]. Thereafter, Fe is delivered to grains via phloem in forms of Fe(III)-DMA or binds to some citrates and proteins [11].
\nThe Zn chemical forms in xylem sap are free ions and Zn partially bound to unidentified chelators [40], while the Zn in phloem sap was dominantly bound to NA [70]. Obata and Kitagishi [71] indicated that some Zn in the xylem (transpiration stream) is transferred to the phloem at the vegetative nodes in addition to the mobilization of Zn from mature leaves in rice. Xylem transfer cells have been found in rice vegetative nodes, and localized metal transporters may support the active xylem-to-phloem transfer of xylem sap Zn [72] and Cd [73].
\nAfter entered into root cells, part of Cd present as Cd-phytochelatin (Cd-PC) complexes are sequestered in the vacuoles, and the others are transported to xylem mediated by OsHMA2 transporter in root pericycle cells [11, 74, 75]. In the phloem, Cd primarily bounds to specific proteins and slightly to thiol-compounds [76]. In contrast to Fe translocation that is mainly derived from leaves by remobilization, xylem-to-phloem transfer system of Cd mainly occurs at the nodes [50]. In rice nodes, the diffuse vascular bundles (DVBs) that encircle the enlarged elliptical vascular bundles (EVBs) are connected to the panicle [77]. A study demonstrated that Cd was predominantly transported toward the panicle instead of other tissues at the panicle-initiation stage through the nodes and ultimately reached grains by positron-emitting 107Cd tracer imaging system (PETIS) [50]. Node I, the uppermost node, is connected to both flag leaf and panicles. Yamaguchi et al. [77] found that Cd concentration was higher in node I than in blade, culm and panicle due to the accumulation of Cd. In addition, a low-affinity cation transporter (OsLCT1), which is highly expressed in the node I, also takes part in Cd transport to grains [16].
\nIn rice seeds, Fe localizes to dorsal vascular bundle, aleurone layer and endosperm, and it localizes to the scutellum and vascular bundle of the scutellum of embryo [78]. Zn is distributed to all parts of the seed with a significantly high value for the aleurone layer and embryo [79]. Low Fe and Zn contents in rice are often restricted due to low available pools of Fe or Zn in soil. Enriching Fe or Zn concentration in grains through either fertilization or water management is referred to as agronomic biofortification, which is a short-term strategy for complementing the breeding programs.
\nFe is abundant in mineral soil, but Fe deficiency still can occur in aerobic condition [80]. The major problem with Fe uptake is solubility. Fe in the soil (usually in the form of Fe2+, either chelated or as a sulfate salt) is easily converted to unavailable Fe3+ under aerobic condition. Thus, application of Fe as fertilizer is not an effective strategy for increasing rice seed Fe [81]. Otherwise, foliar application is a better option to overcome Fe deficiency, increasing grains Fe and its bioavailability in rice [82]. In contrast, as soil changes from aerobic to anaerobic conditions after flooding, Fe-oxides are dissolved when the Fe3+ is reduced to Fe2+, which weakens the oxide stability and increases its water solubility [83]. In fact, irrigation management in rice strongly influences soil redox potential, which affects the availability of Fe, so flooded soil nearly always has sufficient Fe for rice uptake [4].
\nZn status and content in soil are the dominant factors restricting Zn content of rice seeds, followed by rice genotypes and fertilizers [84]. In aerobic condition, Zn mainly presents in soil in the form of ion Zn2+. The application of Zn as fertilizer is effective in promoting rice growth and also in the fortification of rice with Zn [85, 86]. However, the availability of Zn decreases with flooding due to precipitation as insoluble zinc sulfide [87] or as insoluble carbonates mixtures [83]. Positive effects of soil Zn fertilization on grains Zn have been noticed primarily with aerobic water management [84]. In addition, foliar Zn application compared to soil Zn fertilization has been more effective in improving grains Zn concentration in flooded condition [88].
\nAlthough foliar application of Fe or Zn is more effective than soil application for increasing Fe or Zn content in rice grains, the efficiency of foliar applied Fe or Zn also depends on the application stages [89]. Late season foliar application of Zn or Fe at flowering or at early grain filling stage is more effective in improving grain Zn or Fe, respectively, than early season application [90, 91]. Although the level of Zn in grains is positively related with Fe, research showed that foliar fertilization of combined Fe and Zn fertilizers enhanced both grain Fe and Zn content without any antagonistic effects [82], indicating that fertilization of one element does not affect the grains concentration of the others [82, 92]. Totally, in order to increase both Fe and Zn content in rice grains under anaerobic or flooded conditions, the most effective fertilization strategy is a combination of foliar Zn and Fe spray soon after flowering or at early grain filling stage [4]. HarvestZinc Fertilizer Project started in 2008 and aimed at assessing the potential of Zn fertilizer in order to increase Zn content in cereal grains, especially in wheat and rice.
\nN fertilizer application has been reported to be related with Fe and Zn content in rice grains. Optimized N fertilizer application could increase grains Fe and Zn content in several crop species, including rice under sufficient Zn supply [92, 93, 94]. The reason is suggested as follows: (1) N nutrition promotes protein synthesis, which is a major sink for Fe and Zn [92]; (2) N nutrition enhances the expression of Zn and Fe transporter proteins, such as ZIP family transporters [92]; (3) N nutrition enhances the production of N compounds, such as NA and DMA [95]; (4) N nutrition increases Fe and Zn accumulation time by increasing vegetative growth and grain filling periods [4]. In contrast, N fertilizer can decrease rice grains Zn content under low Zn condition by increased biomass production and enhanced biological dilution [94]. In summary, optimized N fertilization application in rice production is very important to regulate Fe and Zn accumulation.
\nAs a result of similar physical and chemical characteristics of Zn and Cd [96], Cd is mainly present as free Cd2+ in soil under aerobic condition regardless of soil redox potential [97], and the effect of flooding on Zn mobilization is indirect rather than direct compared with Fe. Cadmium in acidic soil is ionized as Cd+ [48] and moves toward root system and translocates within plants, resulting in Cd accumulation eventually [98]. In previous reports, phosphate (P) fertilizer was thought to increase rice Cd accumulation [99, 100]. Because Cd emerges in the rock phosphate used for P fertilizer production, P fertilizers generally contain significant amounts of Cd [98]. Nowadays, these relatively high-Cd phosphate rock sources have been avoided in the fertilizer. Sarwar et al. [98] reported that mono-ammonium-phosphate (MAP) could enhance Cd solubility and uptake by lowering soil pH. However, Bolan et al. [12] reported that P fertilizer can reduce Cd solubility by insoluble Cd formation such as Cd(OH)2 or Cd3(PO4)2. Yang et al. [101] proposed that P deprivation decreased rice Cd uptake by competitively increasing Fe uptake and accumulation. P deprivation also enhances the sensitivity to Cd in rice plants by inhibiting biomass accumulation and reducing PCs synthesis deprivation.
\nAn increasing number of evidences show that different N fertilizer forms and content affect Cd accumulation in rice. Sarwar et al. [98] reported that enhanced N application increased biomass production and reduced Cd toxicity to some extent due to dilution effect. N application increased soluble protein that could bind mobile Cd to immobile form. Different N fertilizer forms also have relationships with Cd uptake and accumulation in rice [102]. NH4+-containing fertilizer is considered to contribute to enhance Cd uptake [98]. NH4+-containing fertilizers acidify rhizosphere by proton excretion from root cells, exchanging with NH4+ and leading to low pH in soil [103]. In low pH soil, Cd moves toward root system and translocates within plants, resulting in Cd accumulation. In addition, NH4+ can trigger cell membrane depolarization and lead to influx of NH4+ into root cells, which accelerates translocation of Cd from root to shoot though this mechanism reduces Cd uptake in a certain way [98, 103]. In contrast, NO3−-containing fertilizer causes simultaneous NO3− and proton absorption by root cells, leading to high pH [99], and cell membrane polarization caused by nitrate can produce Cd detoxification mechanism [98]. Nevertheless, Xie et al. [104] found that plants supplied with NO3− accumulated more Cd than NH4+ treatment by Thlaspi caerulescens in hydroponic experiment, suggesting that effects of NH4+ and NO3− on Cd uptake are not simply attributed to rhizosphere pH transformation or charge distribution of cell membrane. Yang et al. [105] found that rice fed with excess NO3− not only enhanced Fe uptake but also increased Cd uptake by upregulating the expression of OsIRT1. In addition, Wangstrand et al. [106] once proposed that application of N fertilizer was dependent on different growth stages and recommended that more N fertilizer should be applied at the vegetative stage while less N doses should be applied during the grain filling stage.
\nBesides P and N, other fertilizers are also related with Cd accumulation in rice. Fe is reported to remarkably increase Cd concentration in root and shoot of rice [107]. In contrast, a peculiar mechanism against Cd stress by application of Fe fertilizer is iron plague (IP) formation [96]. IP can serve as a barrier and prevent Cd from entering into root cells, resulting in reduced Cd accumulation while enhanced Fe concentration in rice [108]. Si application can reduce mobilization of Cd due to increased pH in soil [98], and complexes formation of Si with Cd is another mechanism for alleviating Cd toxicity in rice [96]. Application of S fertilizer may decrease Cd toxicity in the form of insoluble CdS, by which reduces mobility of Cd in soil [109]. S also participates in GSH and PCs biosynthesis. S increases Cd tolerance by forming Cd-PCs complexes and being transported into vacuoles in rice cells [96, 98, 110].
\nPb accumulation in rice was wildly reported in Southeast Asian countries, such as China. Many researchers reported the toxic effects of Pb on rice growth and mineral absorption [111], but researches on reducing Pb accumulation in rice grains by water and fertilizer managements are still limited. Hu et al. [112] reported that Selenium (Se) application reduced Pb concentration in rice tissues but had no significant effect on Pb accumulation in brown rice grains. Soil remediation methods are applied to reduce Cd/Pb toxicity to some extent, including soil removal, replacement, inversion and flooded condition before and after heading [41, 113], but it is not easy to apply. In summary, more work is still needed to explore the effect of water and fertilizer management on Pb accumulation in rice grains.
\nSince 1992, researchers at International Rice Research Institute (IRRI) have evaluated the genetic variability of Fe [114] and Zn [115] concentration in rice grains. The range in Fe and Zn contents of 939 varieties tested in one study were 7.5–24.4 μg g−1 for Fe, and 13.5–58.4 μg g−1 for Zn [116]. Among these 939 varieties, high grains Fe and Zn concentrations were identified, including Jalmagna, Zuchem, and Xua Bue Nuo [116]. HarvestPlus Challenge Program launched in 2004 supports biofortification of staple food crops, including rice for increased Fe, Zn, and vitamin A. However, iron biofortification of rice based on conventional breeding has met with only marginal success. The iron level achieved to date is still too low to address the required target level set by HarvestPlus (around 14 μg g−1), indicating that iron biofortification in rice remains a challenge [117]. In contrast, a number of varieties of biofortified zinc in rice and wheat are now available or being tested in countries all over the world, including India, Bangladesh, and Pakistan. Complementing the traditional breeding efforts, modern transgenic technology provides perspectives for efficiently improving Fe and Zn content of rice grains to dietary significant level for humans’ nutrition [118].
\nRecent attempts on the biofortification of Fe and Zn in rice grains using transgenic techniques have shown some positive results. Overexpression of the barley NA synthase gene HvNAS1 in rice plants caused an increase in DMA and NA concentrations in root, shoot, and seed, accompanied with enhanced Fe, Zn, and Cu concentrations in grains [119]. Zheng et al. [120] indicated that biofortified rice with NA could efficiently enhance bioavailability by overexpression OsNAS1 in rice endosperm. Alexander et al. [121] constructed three rice populations overexpressing OsNAS1, OsNAS2 and OsNAS3. These constitutive overexpression of the OsNAS genes led to increased NA level, positively correlated with enhanced Zn concentration both in unpolished and polished grains, which reduces Zn nutrient loss to some extent due to polishing process. Goto et al. [122] demonstrated that high level of Fe in rice endosperm could be acquired by overexpression of ferritin. Swamy et al. [123] suggested that overexpression of the ferritin gene OsFer2 in basmati rice (Pusa Sugandh II) was observed to accumulate higher levels of Fe and Zn. Combination of upregulated expression of ferritin with overproduction of NA can significantly enhance Fe and Zn content [88]. In addition, manipulation of specific transporters involved in Fe/Zn uptake and translocation is also considered to be promising approach for enhancing Fe/Zn content. Ishimaru et al. [68] introduced OsYSL2 mediated by sucrose transporter (OsSUT1) promoter into rice plants due to location of OsSUT1 around endosperm, resulting in high concentration of Fe in polished rice. Overexpression of the Fe transporter gene OsIRT1 or OsYSL15, the Fe deficiency-inducible bHLH transcription factor OsIRO2, and knockdown of the vacuolar Fe transporter gene OsVIT1 or OsVIT2, were regarded as an effective approaches to increase the Fe concentration of seeds [124]. Overexpression of OsHMA3 enhanced the uptake of Zn by upregulating the ZIP family genes in the root [125]. OsHMA2 was involved in loading of Zn to the developing tissues in rice [75]. Quantitative trait locus (QTL) analysis is a useful approach to identify responsible genes for the respective transport processes [126]. Anuradna et al. [127] identified QTLs and candidate genes for Fe/Zn transport in rice seeds. OsYSL1 and OsMTP1 are responsible for Fe transport, while OsARD2, OsIRT1, OsNAS1, OsNAS2 are responsible for Zn transport. Ishikawa et al. [128] detected four QTLs (qGZn9, qGZn10, qGZn2–1, qGZn2–2) responsible for high Zn accumulation, and qGZn9 showed the best effect, which provides valuable allele for breeding rice with high Zn level in grains.
\nGenotype dependence has been well observed for the accumulation of Cd in rice. More Cd accumulated in shoots and grains of indica cultivars than japonica cultivars [55, 129, 130]. Recently, Cd and Pb contents of 100 top Chinese rice cultivars were determined. The results also showed that indica accumulated more Cd than japonica [131]. Studies on rice screened for Cd-free, but Fe/Zn-rich cultivars have been an important issue in agricultural field. Significant efforts have been made on breeding of low-Cd accumulating rice cultivars in Japan, where Cd accumulation in rice grains has long been recognized as serious agricultural issues [41, 132]. Ishikawa et al. [132] identified and screened three low-Cd mutants (lcd-kmt1, lcd-kmt2, and lcd-kmt3) with japonica rice cultivar, Koshihikari, which acted as parent by the way of carbon ion-beam irradiation, showing that there were lower Cd concentration in grains of the three mutants than Koshihikari wide type (WT). Such three low-Cd mutants were attributed to mutations of OsNRAMP5 responsible for Cd transport in rice by sequence analysis [132]. The three low-Cd mutants have different mutation sites in OsNRAMP5. An insertion of transposon mPingA1, which was activated by ion beam and preferred to insert into exon of OsNRAMP5, was identified in lcd-kmt1, resulting in nonfunction of OsNRAMP5 and decreased Cd accumulation in grains [132]. Similar results were observed in lcd-kmt2 and lcd-kmt3 due to a single-base pair deletion and a large deletion in OsNRAMP5, respectively [132]. Meanwhile, Ishikawa et al. [132] proposed that lcd-kmt1 and lcd-kmt2 were more promising for breeding program according to agronomic traits as a consequence of earlier heading and smaller plant size than Koshihikari WT in lcd-kmt3 [132]. In addition, Abe et al. [133] developed a novel population composed of 46 chromosome segment substitution lines (CSSLs), in which LAC23 served as donor segments and were substituted into Koshihikari. LAC23 could result in lower grain-to-straw ratio than Koshihikari [133]. Therefore, cultivars containing LAC23 performed low Cd content in grains [133]. As for breeding Fe/Zn-rich cultivars, Olive et al. [134] bred high level of ferritin cultivars with rice mega variety IR64 as background and introducing ferritin into endosperm increased Fe content in grains [132, 133]. IR64 mutants obtained from sodium azide treatment were reported to have high Zn level [123]. Booyaves et al. [135] expressed Arabibopsis IRT1 (AtIRT1) in high-iron NFP rice lines, which expressed NICOTIANAMINE SYNTHASE (AtNAS1) and FERRITIN, enhancing Fe contents in both unpolished and polished grains.
\nIn addition, QTL analysis was also applied to identify responsible genes for Cd transport. QTL for Cd concentration in Anjana Dhan (indica rice cultivar) is identified on chromosome 7, responsive gene for which is OsHMA3 [23, 55, 126]. Abe et al. [136] introduced a nonfunctional allele of OsHMA3 from Jarian (indica rice cultivar) into Koshihikari (japonica rice cultivar) by marker-assisted selection, and these plants showed reduced Cd uptake from soil. Suppression of OsLCT1 expression can decrease grains Cd accumulation by RNAi without influencing nutrient accumulation. On the contrary, Fe content in the brown rice is remarkably higher [16], suggesting that RNAi-mediated OsLCT1 suppression in rice is a promising approach to establish “high Fe but low-Cd-rice.” Furthermore, T-DNA-mediated OsLCD knockout mutant showed reduced grain Cd accumulation while having no negative effect on grain yield. Thus, the lcd mutant might be a probable mutant line for further research [137].
\nBreeding low Pb cultivars is also considered to reduce Pb contamination. Developing rice cultivars with low Pb mobilization within root and translocation toward aerial parts to the minimum extent may be a better option to cultivate rice in Pb tainted soils. Li et al. [138] screened three cultivars (Tianyou196, Wufengyou2168, and Guinongzhan) with low Pb level in brown rice. Furthermore, Ashraf et al. [139] compared Meixiangzhan (MXZ-2), Xiangyaxiangzhan(XYXZ), Guixiangzhan (GXZ), Basmati-385 (B-385), and Nongxiang-18 (NX-18) to four different Pb concentrations, indicating that GXZ proved better able to tolerate Pb stress than all other rice cultivars, which are therefore suggested for use in future breeding programs for paddy fields contaminated by Pb.
\nFe and Zn are essential nutrients for humans, but Cd and Pb are toxic at high levels for humans. All these metals accumulated in the grains of rice, a staple cereal worldwide. Compared with Pb, significant progress has been made in investigating the mechanisms for Fe, Zn, and Cd uptake and accumulation in rice grains. These basic discoveries provide us with the increasing possibility to establish high Fe/Zn and low Cd/Pb rice. Here, we summarized a strategy scheme for producing biofortified Fe/Zn but low Cd/Pb rice cultivars as follows (Figure 2). On the one hand, scientists have screened or bred nontransgenic rice cultivars with high Fe/Zn or/and low Cd/Pb in grains based on functional QTLs or genes. These cultivars show no agriculturally or economically adverse traits and can be applied sooner. On the other hand, modern transgenic technology provides perspectives for efficiently improving Fe/Zn content and decreasing Cd/Pb content in rice grains to dietary significant levels for humans’ nutrition (As to Pb, more researches on QTL and genes still needed). Besides improving rice seeds, water and fertilizer management is also significantly related with increased Fe/Zn and decreased Cd/Pb in rice grains. More studies are still needed to optimize irrigation time, fertilizer categories, dosage, and application stages. In addition, although it is available to establish rice cultivars with high Fe or Zn content, or establish rice cultivars with low Cd or Pb separately, interactions among these metals need to be better understood, and more steps are still needed to cultivate rice with all these merits and without decreasing rice production.
\nSchematic diagram of strategies for enhancing accumulation of iron and zinc while minimizing cadmium and lead in rice. Based on functional QTLs or genes, scientists screen or breed nontransgenic rice cultivars with high Fe/Zn or/and low Cd/Pb in grains. Modern transgenic technology provides perspectives for efficiently improving Fe/Zn content and decreasing Cd/Pb content in rice grains. Water and fertilizers management are also significantly related with increased Fe/Zn and decreased Cd/Pb in rice grains.
This research was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LY18C130011 and LY15C130007, Science Foundation of Zhejiang Sci-Tech University, Foundation of Zhejiang Provincial Top Key Discipline of Biology, and Foundation of Zhejiang Provincial Key Discipline of Botany.
\nRetail stores manage millions of items on a day to day basis to deliver to their customers. Point of Sales (POS) systems with barcodes were among the first technologies used to track products across the supply chain and in stores. Barcodes, as an identification technology, are not utilized at item-level but usually represent a group of products. Retailers need to scan products at pallet level at the point of receiving shipments, in inventories entrance and exit places, and at the POS to keep track of what is coming into and leaving stores [1]. With barcode systems, inventory inaccuracy is created because stores barcode scanning are not always performed at the right time and the right location. This inventory inaccuracy leads to a significant loss at retailers. Retailers needed to explore new ways of tracking their items to lower the inventory inaccuracy and prevent consequent losses. Radio Frequency Identification (RFID) technology appears to be the new technology solution that could improve the inventory record accuracy of stores for various items.
\nRFID technology applications have been recognized in many areas such as healthcare, finance, manufacturing, and retail. The share of the RFID market in retail is projected to be the largest of all sectors with about 34% by 2026, followed by transportation sector (25%), financial and security services (22%), and other industries such as healthcare and manufacturing at smaller portions [2]. RFID tags can store more information about each item at real time and can have individualized identification for items versus barcodes with a small data storage capacity that can only identify a group of items. RFID readers do not need to be on the line of sight to read RFID tags information which means items can be scanned more frequently and faster at any movement. These capabilities allow little mistakes in tracking records and largely eliminates inventory inaccuracy.
\nRFID technology’s benefits to retailers were identified early at the beginning of the 21st century. However, RFID’s applications in retail stores on a large scale took a while to be implemented. This paper reviews utilizing RFID, as an ideal solution to retail operations, since earlier this century and will cover a twenty-year horizon (2001–2020) divided into three equally long periods of 2001–2007, 2008–2014, and 2015–2020.
\nIn studies done earlier in this century, RFID was recognized as the next major identification technology to replace barcode systems in the retail industry [3, 4, 5, 6, 7]. Barcode systems have been used to track customer purchases, to manage inventory records, and to offer promotion and advertising in retail since 1970 [8]. Barcode tags, however, need to be on the line of readers to be read, a requirement that makes physical inventory counting a labor-intensive task and prevents stores from updating their inventory records frequently and on time. Therefore, with barcode systems, inventory inaccuracy is significant [9]. Inventory inaccuracy refers to the difference between inventory on record and the actual number of items on hand in stores. Inventory inaccuracy is caused by many factors such as transaction errors in the POS system, or shrinkage caused by possible employee/customer theft. Inventory inaccuracy means that stores may not be able to place inventory orders on time, resulting in out-of- stock conditions and consequently losing sales and hurting customer shopping experience. RFID technology, on the other hand, enhances product visibility in store operations and across the supply chain through the ease of reading RFID tag information and updating inventory records on a real-time basis.
\nStudies have investigated RFID benefits in different areas of retail operations, such as supply chain management, and show how inventory inaccuracy and consequently out-of-stock conditions are improved with the implementation of RFID across the supply chain [10, 11, 12]. Enhanced information visibility, provided by RFID in the supply chain, decreases uncertainties and lowers high inventory costs associated with the uncertainties [13, 14].
\nMany pilot studies during this period investigated and explored the applications of this technology at the pallet level, case level, and item levels in stores [1, 6, 12, 15, 16]. [1] conducted a case study in 2005 to analyze pallet and case-level implementation of RFID and enhanced visibility generated at the receiving gates and entrance doors from backstore to sales floors. They demonstrated that safety stock and inventory holdings can be significantly reduced and RFID benefits are broad, ranging from labor efficiencies to inventory management improvements. Cost–benefit analyses in this period showed that pallet-level implementations of RFID were more cost effective than case-level implementations.
\nMetro Group in Germany conducted some case studies in their stores to show item-level RFID applications can improve customers’ shopping experiences as well. They introduced some tools provided by RFID technology such as automatic checkout, smart carts that help customers navigate stores and find their items easier and faster, and smart dressing rooms that help customers find their desired apparel items more conveniently [6, 16]. They demonstrated that utilizing these tools significantly enhances customers’ shopping experience.
\nWalmart retail stores in the US were the first retailers that decided to mandate the implementation of RFID at pallet and case level across some of their supply chain in 2005. Walmart also did a pilot study with 24 stores over a period of around 6 months to measure how RFID can improve inventory management. They demonstrated out-of-stock conditions were significantly reduced with the implementation of RFID technology [12].
\nIn Asia, two Singaporean fashion retailers piloted item-level RFID on their apparel stores and reported significant reduction in stocking time from hours to minutes that consequently increased the frequency of counting items with handheld readers and improved inventory accuracy [17].
\nFinancial crises and the great recession that started in 2008 did not work to the advantage of retailers that were planning to implement RFID applications in their stores. During financial crises, businesses tend to adopt strategies that could help them sustain and survive by spending low and investing less. RFID technology implementation plans were mostly postponed or slowed down during the financial crises. However, this period was the best time to develop some foundations with respect to policies, regulations, and standardization of the technology.
\nPrivacy issues raised by consumer protection agencies and standardization issues across different platforms put forward by case studies and pilot projects led to the development of some regulations and privacy policies by governments, institutions, and businesses. European Commission (EC) took an active role by funding many initiatives across Europe [18]. Initiatives such as Coordinating European efforts for promoting the European RFID value chain (CE RFID) [19] and Building Radio frequency Identification solutions for the Global Environment (BRIDGE) [20], conducted from 2006 to 2009, highlighted that wide implementation of RFID technology needs some regulations, standardizations, and privacy policies in place. For example, the BRIDGE project, coordinated by GS1, helped the industry to develop standardizations such as establishing a common format for the data stored on RFID tags, or the availability of possible frequency bands.
\nRFID tags can store identifiable consumers’ private data, which need to be protected. Therefore, EU members signed an agreement on the Privacy Impact Assessment framework in order to protect consumer privacy [21, 22, 23]. This agreement established some rules to be followed in the design of smart chips such as RFID tags to protect the privacy of consumers’ data. Consumers should be informed if RFID tags are utilized in stores. In addition, tags must be deactivated at the point of sales at no cost [24]. This framework was later expanded to cover some rules for smart meters as well. In the United States, lawsuits against RFID application patents as well as privacy issues in 2011–2013 were setbacks for large-scale implementations of the technology. The National Institute of Standards and Technology (NIST) in the US has helped to establish some guidelines to help retailers; however, most of the development of policies and standardizations have been initiated by corporations in the US.
\nIn addition to developing policies and standardizations, businesses had more chances to identify and learn broader applications of RFID technology in retail. The focus of most of earlier pilot studies was how this new tracking technology helps manage inventories better in order to avoid out-of-stock conditions. However, the applications of the technology go beyond only inventory management and tracking items throughout the supply chain. As shown in the balanced scorecard developed in [25], RFID benefits extend to marketing and merchandising operations in retail as well (Figure 1).
\nBalanced scorecard for RFID applications in retail.
In marketing, stores can monitor the behavior of consumers better when customers use tools such as smart carts or smart dressing rooms provided by RFID. Retailers can learn about consumers’ preferences and reflect that in the promotion and advertising offered to customers in real time while they shop. The available tools such as smart dressing rooms and smart carts also enhance customer shopping experience. Use of these tools enables customers to find their desired items more conveniently and faster, which eventually leads to higher customer satisfaction and increase in sales.
\nIn merchandising, enhanced visibility on consumer behavior in stores provided by RFID can help retailers identify better assortments of products. In addition, an enhanced visibility means better shelf-replenishment; that is stores can reduce the shelf space since enhanced visibility on shelves allows retailers to replenish them as soon as they become emptied. Less shelf space leads to holding less number of items on shelves at any given time and consequently less inventory and capital held in stores, which allows retailers to invest in carrying more variety for products in stores.
\nThere were also more studies during this period conducting cost–benefit analysis of the implementation of the technology. The fixed cost of implementation includes middleware, fixed antennas, sensors, and readers and the variable cost includes the cost of tags per item. The cost of tags can be added to the cost of each product but then the big question is who has to pay for that cost. Should the cost be transferred to consumers or should that be shared between retailers and manufacturers? The tag cost as the variable cost of utilizing the technology is huge and cost–benefit analysis studies have shown it to be a major barrier to the implementation of the technology during this period. [26] showed that the cost of tags in item-level implementation of RFID, as the variable cost, is cumbersome. Moreover, the cost can exceed the benefits in some cases depending on the extent to which stores implement RFID applications. The cost barrier was expected to weigh less as the cost of tags became lower over time.
\nSurveys of businesses show the implementation of RFID has picked up in this period. A survey of 60 retail executives throughout the United States and Europe showed about 73% of retailers had plans to implement RFID in 2016 [27]. Another survey in 2018 [28], however, showed that 92% of retailers in North America plan on implementing RFID, which is about a 20% increase from the 2016 results.
\nThe cost of implementation has been decreasing over time, as expected, and at the same time retailers have learned how to partially implement the technology. Retailers realized that they do not need to fully implement the technology. In some cases, only tags and hand-held readers are used to add visibility of items in stores without many of the infrastructures such as antennas. Cloud services, on the other hand, have allowed retailers to eliminate some of the middleware cost as well. The leading European fashion stores C & A is one of many retailers that explored lower cost implementations with partial utilization of the technology [29].
\nRFID platforms can generate big data that are the records of tracking items throughout the supply chain and stores in real time. Businesses need big data and business analytics capabilities to fully utilize technologies [30]. The results of the analysis of such data can help retailers improve their processes such as shelf-replenishment process as well as variety and assortment planning that have been used in the same format for many years. A new timely replenishment process can result in better management of physical space, layouts, and lowering holding costs in stores. Furthermore, a better variety and assortment planning means fulfilling customers’ expectations and eliminating unpopular items that releases some capital and allow investment opportunities in other areas in retail.
\nCompeting technologies to RFID have been developed and utilized over time as well. For example, Quick Response (QR) codes give retailers better ability to manage items compared to barcodes, Near-Field Communication (NFC) technology has some capabilities compared to UHF RFID, and most recently Amazon’s cameras increase product visibilities in stores for fast checkouts. In addition, retailers have different priorities in investing in new technologies and there is competition for dollars invested in various technologies by retailers. For instance, a retail chain can focus on improving inventory operations, but another retailer may be focused on improving marketing operations and customer shopping experience in stores by developing new apps that can assist customers make decisions during their shopping time in stores. In a different example, Gucci as an Italian luxury brand name does not suffer from inventory inaccuracy issues but their priority is customer shopping experience and they have utilized RFID tags to protect customers against counterfeiting across the supply chain until products reach their customers [31].
\nOmnichannel retail has been widely available during this period of time. Retailers’ customers can shop at any time, in any place, and via any shopping channel. Omnichannel retailing needs accurate inventories and enhanced product visibility more than any other time. Item-level RFID can, therefore, accommodate the needs of omnichannel retail more than other technologies available [32]. In addition, blockchain as the latest technology in retail can provide automatic exchange of product data carried by RFID tags between different partners across the supply chain. The blockchain in retail solutions are currently being studied in a consortium of large retailers such as Nike, Macy’s, and Dillard’s in an RFID lab at Auburn University [33].
\nThe 3-S model (substitution, scale, and structure) introduced in [34] discussed and projected different phases of the adoption of RFID earlier when this technology was introduced. Later the 3-S model was adapted by [35] to describe the current stage of retailers’ implementation of RFID applications in retail (Figure 2). The substitution and scale stages are covering mostly what has been achieved during the three periods discussed in this paper. In the substitution phase, the RFID technology was utilized to replace the applications of barcode systems in tracking products. In the scale phase, the RFID applications are enabling retailers to manage their operations with more accuracy, efficiencies, and at a higher speed and scale. The structure phase, that is re-engineering processes and completely overhauling retail operations, is still underway. The RFID technology will enable retailers to accomplish things they could not imagine before and allows retailers to tap into completely new domains and applications.
\n3-S model for RFID retail adoption.
Retailers have different needs based on the way they operate in stores. Some retailers must manage large inventories in stores. An enhanced visibility on their products help them improve inventory accuracies and avoid out-of-stock and increase their efficiencies. On the other hand, some retailers have small backstore inventories and every item they receive is put directly on their shelves and available to their customers. Inventory management is not their priority, but they need to focus more on customer shopping experience. Therefore, the enhanced visibility of items in stores is expected to promote retailers’ marketing operations. Depending on the way retailers operate and what their priorities are, retailers have to plan on implementing appropriate applications of RFID technology.
\nAs discussed in this paper, RFID has been utilized broadly with various applications. As a revolutionary technology, RFID’s implementation can go beyond improving the current processes in retail operations. The current processes can innovatively change to debut completely new applications that are only possible with the enhanced visibility of items in real time. The ensuing big data that is derived from the visibility provided by RFID tags can be analyzed, leading to innovations in retail operations.
\nImplementing item-level RFID needs to be part of omnichannel strategy in the retail sector. With the wide-spread usage of online retail services such as Amazon, the competition in retail is tougher than ever before. In omnichannel services, retailers need to grant their customers easy access via different channels and make their products available in a variety of delivery services. The accessibility and fast delivery will not be possible with the level of visibility provided by barcode systems. Utilization of technology in retail is evolving quickly and RFID technology is the one that can definitely help retailers win in this overhaul.
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