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The reason for this may be due to their lack of awareness of the importance of health and the consequent lack of proper self-care. Health can generally be considered an essential basis of life, but many people still do things that show that health is not a priority in their lives. They spend a lot of time on the opportunities they find but do not spend time learning what is good for them to exercise or stay healthy; they spend their budget on Nonsignificant things. But for a more nutritious diet, they pay less.
According to the World Health Organization’s definition, health is a state of complete physical, mental and social well-being and not only the absence of disease or infirmity. This definition of health has been given more attention since 1978 at the UN Summit in Almaty. Due to the considerable differences in the level of health in different countries of the world, the members of this organization were required to provide Primary Health Care by providing an essential package aimed at reducing the health gap between different countries and with the goal of Health for All by the year 2000. Undoubtedly, one of the most critical concerns and challenges that different countries have faced in providing primary health care to their population has been the lack of resources in the face of the growing need to receive this care during all these years.
So from the perspective of health economists, health is a durable good, or type of capital, that provides services. The flow of services produced from the stock of health capital is consumed continuously over an individual’s lifetime. Each person is assumed to be endowed with a given stock of health at the birth time, such as a year. Over the period, the stock of health depreciates with age and maybe promoted by investments in Health services. Death occurs when an individual’s stock of health falls below a critical minimum level.
To request a product or service, you must ask for it, afford it, and have a specific plan for purchasing it. Desires are, in fact, the unlimited desires and inclinations that people have for goods and services. Imagine being able to afford something if you could afford it or it was not so expensive. When we make choices, scarcity guarantees that many of our desires will never be met. Demand reflects our plan and vision for the demands that will be met. The amount of goods and services that the consumer plans to buy depends on many factors: commodity prices, related commodity prices, personal income, expected future prices, population, advertising, and preferences.
We must first discuss the relationship between the demand for a good or service and the price. All other factors influencing demand must be kept constant to study this relationship called the Citrus Paribus principle. The demand for a good or service is inversely related to its price; as the price increases, the demand for it decreases, and vice versa. Of course, the rate of demand response to price changes is not the same for all goods, which will be discussed in the topic of elasticity [1].
The demand curve is a geometric location of points where the dependent variable is the rate of use of a good, and the independent variable is the price of that good; in general, the demand curve shows the maximum demand for a good at different prices and also represent the ultimate price for a certain amount of a good. Usually, the price variable is shown on the y axis and the amount of goods or services on the x-axis (Figure 1).
Demand curve.
This shows the maximum amount someone is willing to pay for a small increment in consumption rate. Care should be taken in using the “demand” to mean the amount of consumption of a particular good or service at a specific price and to use it to mean a range of corresponding values in the price range (for example, one point on the demand curve versus the whole Points on the curve). The demand for a good or service is a function of its relative price and buyers’ income. The demand curve is a two-dimensional representation of this process. Responding to price changes is moving along the demand curve and responding to changes in revenue as the entire demand curve changes and shifts (Figure 2). Some of the characteristics of the demand side that should always be kept in mind when using the demand curve in healthcare, especially when making normative statements about well-being, are: Uncertainty on the part of the consumer about the likelihood of future illness; Side effects, the effectiveness of treatment methods and their possible cost. When sick, people experience anxiety, disability, suffering, and pain that may not be considered in the theory of desirability; It is also important to note that there may be an external demand for care and treatment of a person in addition to their need; And the fact that the price at which the applicant responds to the service or goods may in no way be an accurate reflection of the final cost of providing that product or service to the service provider.
Change in demand curve.
We can also consider the demand curve as a payment ability curve that measures the ultimate benefit. This curve shows the highest price a person is willing and able to pay for the last unit purchased. If there are fewer goods available, the highest price that a person is willing and able to pay for a larger unit will be high. But as the quantity of available goods increases, the ultimate benefit of each additional unit decreases, and the highest price offered on the demand curve decreases.
In addition to the price of the product in question, which is inversely related to the demand for that product, we can examine the relationship between the demand for a product and other factors in the space of the demand curve.
A complementary good is a good that is used with another commodity, and if the price of one of these commodities increases, in addition to the demand for that commodity, the demand for the other commodity also decreases.
Medical care consists of countless goods and services that maintain, improve, or restore a person’s health. For example, a young man may have wrist surgery to repair a torn tendon so he can return to work, an older woman may have cataract surgery to improve her vision, or a parent may have to Bring their child to a healthcare center for an annual dental checkup to prevent future problems. Prescription drugs, prescription glasses, and dentures are examples of medical supplies, while surgeries, periodic physical examinations, and visits to medical professionals are examples of medical services. Preventive and medical care are heterogeneous, making it difficult to measure and quantify medical care units accurately. Medical care services have four characteristics that distinguish these from other goods and services: intangibility, inseparability, inventory, and inconsistency.
Intangibility means that the five senses are incapable of evaluating medical services. Unlike new shoes, a vegetable salad dinner, or a new cell phone, the consumer cannot see, taste, or touch medical services. Indivisibility also means that the production and consumption of a medical service take place simultaneously. For example, when you see an ophthalmologist for an examination, you use ophthalmic services right at the time of production. In addition, a patient is often seen as both a producer and a consumer. Inventory is directly related to inseparability. Because the production and consumption of a medical service occur simultaneously, healthcare providers cannot store or maintain medical services. For example, a physiotherapist cannot provide a list of different physiotherapy services to meet demand during busy times. Finally, inconsistency means that the variety, composition, and quality of medical services are very different. Although different people may see a doctor simultaneously, there are various reasons for visiting a doctor. One person may see a doctor because of a typical physical problem, while another may see a doctor because of a heart attack. The combination of prescribed medical care or the frequency of its use can vary significantly from person to person and at different times [4, 5].
The following factors affect the demand for healthcare:
Needs (based on patient perception)
Patient preferences
Price or cost of use
Income
transportation cost
waiting time
Quality of care (based on patient perception)
The use of healthcare depends on demand and availability. If planners allocate resources based on need rather than demand, they may find themselves in a situation where some services are underused, and some services are overused.
Just as the healthcare market is different from other commodities, so is the demand for healthcare different from the simple demand model. One of the differences is that healthcare is not demanded because it is self-satisfying. After all, healthcare itself does not lead to satisfaction. Instead, healthcare is in demand because people are satisfied with their activities when they are healthy. So the demand for healthcare is a derived demand.
Patients’ perceptions of their need and capacity to benefit from healthcare are strongly influenced by physicians and healthcare providers. Although in economics, it is assumed that consumers can make informed decisions about their consumption patterns, healthcare consumers delegate this decision-making power to healthcare workers who are more aware of them. This phenomenon is due to information asymmetry between healthcare providers and patients, which carries the risk of induced demand by providers to increase revenue. Another complication stems from the fact that healthcare is highly heterogeneous. Each patient has a relatively different combination of pain and symptoms. Therefore each patient needs to purchase a fairly different package of care that both the patient and the physician have uncertainty about its effectiveness in meeting the need.
Another critical difference is that many health services are paid for by third parties. Payments by third parties or insurance companies Although they significantly increase people’s purchasing power for healthcare, it is also important to note that they can lead to ethical risks and increase demand for services that patients may not need.
Demand for healthcare depends on the level of consumption of an individual in case of illness; the amount of consumption can differ according to the factors affecting the demand, such as income, service price, education, norms, social traditions, and quality. A person’s decision to use or use services is related to his or her illness/injury status rather than healthcare. Developing countries are focused on promoting healthcare as an essential policy to improve health outcomes and fulfill international obligations and universal coverage of health services. However, many policies have focused more on improving physical access than on the demand-side healthcare needs pattern. In low-income countries, allocating scarce financial resources is based on clear criteria for the impact of investment in the health sector on service demand.
In these countries, due to the lack or weakness of social security systems, the occurrence of the disease leads to increased health costs and reduced labor productivity and leads to a loss of household welfare. In developed countries, due to insurance, many health services are used with minimal consumer participation in the payment; however, in developing countries, concerns about less use of health services, to the extent of supply. Or poor access is associated. However, even in health services, due to various barriers on the demand side, related to the cost of treatment, travel costs, and quality of services, the rate of exploitation is low. Also, the importance of a person’s health status in a clinical context is related to the analysis and social evaluation of a person’s health and social environment. Studies have shown that the risk of death is related to people’s perception of the health importance of maintaining it. Since one of the priorities of health policymakers is to improve people’s health, various factors that directly and indirectly affect the demand for health services should be examined more carefully. Identifying the factors influencing individuals’ decision to request healthcare services and choosing from different providers. Therefore, evaluating the determinants of demand for health services will introduce and implement appropriate incentive schemes to encourage better health services. Because health is one of the essential components of human capital and healthy human beings are the center of sustainable development, health can significantly increase the ability of individuals to perform various activities, including productive activities. As a result, people are looking for health. At the individual level, health is mainly influenced by multiple factors such as biological factors, lifestyle, purchased non-medical services, purchased medical services and goods, and different socio-economic characteristics. People’s understanding and expectation of healthcare quality are essential because the perceived quality of health services often affects health services’ behavior and consumption patterns [6].
Grossman used human capital theory to explain the demand for healthcare. According to human capital theory, people invest in themselves through education and health to increase their income. Grossman proposed an approach in which many important aspects of the demand for health services differ from the traditional demand approach:
That consumers are looking for health and demand health services to achieve it.
To achieve health, consumers buy health services from the market and combine them with their efforts to improve health, such as diet and exercise.
The health gained lasts more than a period and is not immediately depreciated to be analyzed as a capital good.
Most notably, health can be considered as both a consumer good and a capital good. From the people’s point of view, health is a consumer product because it makes them feel better. As a capital good, it is also suitable for people’s health because it increases the number of healthy days of life to work and earn money. Figure 3 provides a simple diagram that explains the concept of health capital. Just as one thinks that cars or laptops are capital goods that use the flow of their services over time, one can also understand the savings of one’s health capital, the outcome of which is “healthy days”. Outflow may be considered as one dimension of healthy days or measured in several dimensions of physical, mental health, and limited activity. People consume a range of health inputs, including healthcare inputs, diet, exercise, and time, so they invest in health savings. These investments help maintain or improve consumers’ health reserves, providing them with healthy days. Over time, health reserves may either grow, remain constant, or decrease with age due to illness or injury. As mentioned in Box 3, many technologies may generate health capital, using different amounts of time or health goods and services. Figure 3 shows how the ultimate goal of “healthy days” guides consumer decisions about the amount, time, and cost of investing in health storage. We will see that the prices of healthcare, the rate of wages of individuals, and their productivity in the production of health determine how resources are allocated between health capital and other goods and services that people buy. Consider a consumer who buys market inputs (e.g., medical care, food, clothing) and combines them with his or her own time to generate a health capital reserve that increases his or her utility [2].
Investing in health.
As an economic principle, the price of a good and the demand for that good are inversely related. That is, the higher the price of a commodity, the less demand there is for that commodity, and the lower the price of a good, the greater the demand for it. Price elasticity of demand shows that a one percent change in a good price causes a few percent changes in the demand. For example, if the price of a car rises by one percent, the demand for it will fall by a few percent, and vice versa, if the price of a vehicle falls by one percent, the demand will increase by a few percent.
Three things can happen when we calculate the price elasticity for a commodity:
When a one percent change in the price of a commodity occurs, the demand for that commodity changes by more than one percent. These types of goods are very price sensitive.
When a one percent change in a good price causes the demand for that good to change by less than one percent, this type of product is called inelastic. Demand for this type of goods shows a mild reaction to price changes.
The third case is when a one percent change in the price of a good causes a one percent change in the demand for that good.
If there is an inverse relationship between price and demand, demand elasticity will always be negative because the percentage change in one face or denominator is a negative fraction. Therefore, after calculating the price elasticity of demand, if the result, regardless of the negative sign of the number, becomes more than one, the commodity with elasticity is less than one, the good without elasticity, and if it is equal to one, the good has a single elasticity.
Although the price elasticity of a commodity can be determined only by collecting price information and calculating, some factors affect this ratio.
Alternative goods: The more alternative goods there are, the higher the price elasticity of that product. That is, when the price changes, the demand for that product changes more drastically. Also, price changes in a product cause a shift in the demand for alternative goods. In the healthcare sector, there are usually few alternatives to a health or medical intervention.
Complementary goods: When a product has a supplement, a change in the price of a complementary product causes a change in the demand for another product. Maternal and child care can be mentioned as complementary goods in the field of health (Figure 4).
Types of elasticity.
Commodity prices: In general, if the price of a commodity is very low, the amount of demand does not react to price changes. But high-priced products are attractive. On the other hand, different results are obtained depending on the price at which the demand elasticity is calculated. As mentioned initially, the price of a product has an inverse relationship with the amount of demand. When the price is precisely in the middle of the demand curve of a commodity, the commodity has a single elasticity. Also, if the price is less than the midpoint, the product in that range is unattractive. If the price is above the midpoint, the product will be pulled. You can see this in the chart below.
Marginal modes in demand elasticity.
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\n\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
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\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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Heat stress decreases the secretion of luteinizing hormone and estradiol resulting in reduced length and intensity of estrus expression, increased incidence of anoestrus and silent heat in farm animals. Oocytes exposed to thermal stress lose its competence for fertilization and development into the blastocyst stage, which results in decreased fertility because of the production of poor quality oocytes and embryos. Furthermore, low progesterone secretion limits the endometrial functions, and subsequently embryo development. In addition, the increased secretion of endometrial prostaglandin F2 alpha during heat stress threatens the maintenance of pregnancy. In general, the percentage of conception rate was found to be reduced by 4.6% for each unit increase in temperature humidity index (THI) above 70, and heat stress during pregnancy further slows down the growth of the foetus and results in lower birth weight. In tropical and subtropical regions, during hot days, the testicular temperature may increase and impair both the spermatogenic cycle and semen quality, which culminates in decreased bull fertility. The effects of heat stress on livestock can be minimized via adapting suitable scientific strategies comprising physical modifications of the environment, nutritional management and genetic development of breeds that are less sensitive to heat stress. In addition, the summer infertility may be countered through advanced reproductive technologies involving hormonal treatments, timed artificial insemination and embryo transfer, which may enhance the chances for establishing pregnancy in farm animals.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Govindan Krishnan, Madiajagan Bagath, Prathap Pragna,\nMallenahally Kusha Vidya, Joy Aleena, Payyanakkal Ravindranathan\nArchana, Veerasamy Sejian and Raghavendra Bhatta",authors:[{id:"89780",title:"Dr.",name:"Veerasamy",middleName:null,surname:"Sejian",slug:"veerasamy-sejian",fullName:"Veerasamy Sejian"},{id:"177210",title:"Dr.",name:"Raghavendra",middleName:null,surname:"Bhatta",slug:"raghavendra-bhatta",fullName:"Raghavendra Bhatta"},{id:"177220",title:"Dr.",name:"M",middleName:null,surname:"Bagath",slug:"m-bagath",fullName:"M Bagath"},{id:"201967",title:"Dr.",name:"Govindan",middleName:null,surname:"Krishnan",slug:"govindan-krishnan",fullName:"Govindan Krishnan"},{id:"201968",title:"Ms.",name:"Archana",middleName:null,surname:"Pr",slug:"archana-pr",fullName:"Archana Pr"},{id:"201969",title:"Ms.",name:"Pragna",middleName:null,surname:"Prathap",slug:"pragna-prathap",fullName:"Pragna Prathap"},{id:"201970",title:"Ms.",name:"Aleena",middleName:null,surname:"Joy",slug:"aleena-joy",fullName:"Aleena Joy"},{id:"201971",title:"Dr.",name:"Vidya",middleName:null,surname:"Mk",slug:"vidya-mk",fullName:"Vidya Mk"}]},{id:"55006",doi:"10.5772/intechopen.68650",title:"Immunocastration as Alternative to Surgical Castration in Pigs",slug:"immunocastration-as-alternative-to-surgical-castration-in-pigs",totalDownloads:1876,totalCrossrefCites:9,totalDimensionsCites:19,abstract:"Surgical castration of piglets is a routine practice in pig production used to prevent the incidence of boar taint of pig meat, which may develop in entire male pigs as they reach puberty. This practice is being presently questioned in the European Union, and there is a strong initiative to end it. The initiative is presently voluntary; however, key stakeholders of European pig production sector have signed a declaration, and the actions undertaken by them already affect the business. Before such new concepts in pig production can be implemented, alternative solutions are needed, one of them being immunocastration. The present chapter will thus focus on the presentation of immunocastration as one of the promising alternatives to surgical castration. Theoretical and practical aspects of immunocastration in pig production will be described, and the advantages and disadvantages of this alternative will be summarised. Physiological principles of immunocastration and impacts on metabolism, growth performance, body composition and meat quality will be described and aspects of public acceptability reviewed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Marjeta Čandek-Potokar, Martin Škrlep and Galia Zamaratskaia",authors:[{id:"23161",title:"Dr.",name:"Marjeta",middleName:null,surname:"Čandek-Potokar",slug:"marjeta-candek-potokar",fullName:"Marjeta Čandek-Potokar"},{id:"198220",title:"Dr.",name:"Martin",middleName:null,surname:"Škrlep",slug:"martin-skrlep",fullName:"Martin Škrlep"},{id:"198221",title:"Prof.",name:"Galia",middleName:null,surname:"Zamaratskaia",slug:"galia-zamaratskaia",fullName:"Galia Zamaratskaia"}]},{id:"55696",doi:"10.5772/intechopen.69444",title:"Estrus Cycle Monitoring in Wild Mammals: Challenges and Perspectives",slug:"estrus-cycle-monitoring-in-wild-mammals-challenges-and-perspectives",totalDownloads:1852,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"The knowledge of reproductive physiology is of paramount importance to guide reproductive management and to make possible future application of assisted reproduction techniques (ARTs) aiming ex situ conservation of wild mammals. Nevertheless, information on the basic reproductive aspects of wild mammals remain scarce, and appropriate management practices have not yet been developed for all the species. This chapter discusses the methods most currently used for reproductive monitoring in wild females. Additionally, the difficulties regarding their use in different species and the possibilities of these procedures in captivity or in free-living mammals are addressed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Alexandre R. Silva, Nei Moreira, Alexsandra F. Pereira, Gislayne C.X.\nPeixoto, Keilla M. Maia, Lívia B. Campos and Alana A. Borges",authors:[{id:"90066",title:"Dr.",name:"Alexandre",middleName:"Rodrigues",surname:"Silva",slug:"alexandre-silva",fullName:"Alexandre Silva"},{id:"177090",title:"Dr.",name:"Alexsandra Fernandes",middleName:null,surname:"Pereira",slug:"alexsandra-fernandes-pereira",fullName:"Alexsandra Fernandes Pereira"},{id:"177093",title:"MSc.",name:"Gislayne Christianne Xavier",middleName:null,surname:"Peixoto",slug:"gislayne-christianne-xavier-peixoto",fullName:"Gislayne Christianne Xavier Peixoto"},{id:"198314",title:"Prof.",name:"Nei",middleName:null,surname:"Moreira",slug:"nei-moreira",fullName:"Nei Moreira"},{id:"198315",title:"MSc.",name:"Keilla Moreira",middleName:null,surname:"Maia",slug:"keilla-moreira-maia",fullName:"Keilla Moreira Maia"},{id:"198316",title:"MSc.",name:"Lívia Batista",middleName:null,surname:"Campos",slug:"livia-batista-campos",fullName:"Lívia Batista Campos"},{id:"198317",title:"MSc.",name:"Alana Azevedo",middleName:null,surname:"Borges",slug:"alana-azevedo-borges",fullName:"Alana Azevedo Borges"}]},{id:"56522",doi:"10.5772/intechopen.69549",title:"Role of Melatonin in Reproductive Seasonality in Buffaloes",slug:"role-of-melatonin-in-reproductive-seasonality-in-buffaloes",totalDownloads:1725,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Buffaloes are characterized by seasonal reproductive activity. Anestrus buffalo heifers and lactating buffaloes were used to study the effect of melatonin treatment on the resumption of ovarian activity during out-of-breeding season. Buffaloes of treated group were injected or implanted with melatonin (18 mg melatonin/50 kg body weight). Using CIDR-eCG protocol preceded with melatonin successfully achieved estrus behavior and induced conception rate during out-of-breeding season. Furthermore, the reproductive performance of buffaloes during out-of-breeding season was clearly improved by melatonin implantation in conjunction with CIDR-eCG protocol due to the luteotrophic effect of melatonin expressed as increasing diameter of CL (corpus luteum) and progesterone concentration. This improvement resulted in greater values of conception rate, in melatonin implanted compared to not implanted buffaloes. Melatonin implantation in anestrus buffalo heifers increased the diameter of largest follicles and melatonin concentration but progesterone and luteinizing hormone (LH) concentrations were decreased. In addition, melatonin implantation in anestrus lactating buffaloes increased the SOD (superoxide dismutase) enzyme activity. Sustained release of exogenous melatonin significantly protects against oxidative stress while increasing beneficial total antioxidant capacity (TAC) concentration in summer-stressed anestrus buffaloes. Melatonin implantation in conjunction with CIDR-eCG protocol successfully improved some blood metabolites, in anestrus buffalo heifers during out-of-breeding season under tropical conditions.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Tamer Awad Ramadan",authors:[{id:"197651",title:"Dr.",name:"Tamer",middleName:"Awad",surname:"Ramadan",slug:"tamer-ramadan",fullName:"Tamer Ramadan"}]},{id:"54974",doi:"10.5772/intechopen.68651",title:"Markers for Sperm Freezability and Relevance of Transcriptome Studies in Semen Cryopreservation: A Review",slug:"markers-for-sperm-freezability-and-relevance-of-transcriptome-studies-in-semen-cryopreservation-a-re",totalDownloads:1586,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"Advances in sperm assessment techniques have offered new perspectives to improve the technology of semen cryopreservation. This review addresses some recent achievements in the proteomics of seminal plasma and spermatozoa and exemplifies its importance as markers for sperm fertility following cryopreservation. Recent advances in transcriptome studies on sperm RNA-Seq data have generated new information aimed to unravel the physiological roles of RNAs in the sperm-egg fertilization processes and their associations with male fertility. The relevance of the sperm freezability markers and the potential associations of RNA-profiling sequences with the sperm biological functions have been discussed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Leyland Fraser",authors:[{id:"199650",title:"Dr.",name:"Leyland",middleName:null,surname:"Fraser",slug:"leyland-fraser",fullName:"Leyland Fraser"}]}],mostDownloadedChaptersLast30Days:[{id:"55696",title:"Estrus Cycle Monitoring in Wild Mammals: Challenges and Perspectives",slug:"estrus-cycle-monitoring-in-wild-mammals-challenges-and-perspectives",totalDownloads:1852,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"The knowledge of reproductive physiology is of paramount importance to guide reproductive management and to make possible future application of assisted reproduction techniques (ARTs) aiming ex situ conservation of wild mammals. Nevertheless, information on the basic reproductive aspects of wild mammals remain scarce, and appropriate management practices have not yet been developed for all the species. This chapter discusses the methods most currently used for reproductive monitoring in wild females. Additionally, the difficulties regarding their use in different species and the possibilities of these procedures in captivity or in free-living mammals are addressed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Alexandre R. Silva, Nei Moreira, Alexsandra F. Pereira, Gislayne C.X.\nPeixoto, Keilla M. Maia, Lívia B. Campos and Alana A. Borges",authors:[{id:"90066",title:"Dr.",name:"Alexandre",middleName:"Rodrigues",surname:"Silva",slug:"alexandre-silva",fullName:"Alexandre Silva"},{id:"177090",title:"Dr.",name:"Alexsandra Fernandes",middleName:null,surname:"Pereira",slug:"alexsandra-fernandes-pereira",fullName:"Alexsandra Fernandes Pereira"},{id:"177093",title:"MSc.",name:"Gislayne Christianne Xavier",middleName:null,surname:"Peixoto",slug:"gislayne-christianne-xavier-peixoto",fullName:"Gislayne Christianne Xavier Peixoto"},{id:"198314",title:"Prof.",name:"Nei",middleName:null,surname:"Moreira",slug:"nei-moreira",fullName:"Nei Moreira"},{id:"198315",title:"MSc.",name:"Keilla Moreira",middleName:null,surname:"Maia",slug:"keilla-moreira-maia",fullName:"Keilla Moreira Maia"},{id:"198316",title:"MSc.",name:"Lívia Batista",middleName:null,surname:"Campos",slug:"livia-batista-campos",fullName:"Lívia Batista Campos"},{id:"198317",title:"MSc.",name:"Alana Azevedo",middleName:null,surname:"Borges",slug:"alana-azevedo-borges",fullName:"Alana Azevedo Borges"}]},{id:"55491",title:"Mitigation of the Heat Stress Impact in Livestock Reproduction",slug:"mitigation-of-the-heat-stress-impact-in-livestock-reproduction",totalDownloads:4243,totalCrossrefCites:9,totalDimensionsCites:23,abstract:"Heat stress affects the fertility and reproductive livestock performance by compromising the physiology reproductive tract, through hormonal imbalance, decreased oocyte quality and poor semen quality, and decreased embryo development and survival. Heat stress decreases the secretion of luteinizing hormone and estradiol resulting in reduced length and intensity of estrus expression, increased incidence of anoestrus and silent heat in farm animals. Oocytes exposed to thermal stress lose its competence for fertilization and development into the blastocyst stage, which results in decreased fertility because of the production of poor quality oocytes and embryos. Furthermore, low progesterone secretion limits the endometrial functions, and subsequently embryo development. In addition, the increased secretion of endometrial prostaglandin F2 alpha during heat stress threatens the maintenance of pregnancy. In general, the percentage of conception rate was found to be reduced by 4.6% for each unit increase in temperature humidity index (THI) above 70, and heat stress during pregnancy further slows down the growth of the foetus and results in lower birth weight. In tropical and subtropical regions, during hot days, the testicular temperature may increase and impair both the spermatogenic cycle and semen quality, which culminates in decreased bull fertility. The effects of heat stress on livestock can be minimized via adapting suitable scientific strategies comprising physical modifications of the environment, nutritional management and genetic development of breeds that are less sensitive to heat stress. In addition, the summer infertility may be countered through advanced reproductive technologies involving hormonal treatments, timed artificial insemination and embryo transfer, which may enhance the chances for establishing pregnancy in farm animals.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Govindan Krishnan, Madiajagan Bagath, Prathap Pragna,\nMallenahally Kusha Vidya, Joy Aleena, Payyanakkal Ravindranathan\nArchana, Veerasamy Sejian and Raghavendra Bhatta",authors:[{id:"89780",title:"Dr.",name:"Veerasamy",middleName:null,surname:"Sejian",slug:"veerasamy-sejian",fullName:"Veerasamy Sejian"},{id:"177210",title:"Dr.",name:"Raghavendra",middleName:null,surname:"Bhatta",slug:"raghavendra-bhatta",fullName:"Raghavendra Bhatta"},{id:"177220",title:"Dr.",name:"M",middleName:null,surname:"Bagath",slug:"m-bagath",fullName:"M Bagath"},{id:"201967",title:"Dr.",name:"Govindan",middleName:null,surname:"Krishnan",slug:"govindan-krishnan",fullName:"Govindan Krishnan"},{id:"201968",title:"Ms.",name:"Archana",middleName:null,surname:"Pr",slug:"archana-pr",fullName:"Archana Pr"},{id:"201969",title:"Ms.",name:"Pragna",middleName:null,surname:"Prathap",slug:"pragna-prathap",fullName:"Pragna Prathap"},{id:"201970",title:"Ms.",name:"Aleena",middleName:null,surname:"Joy",slug:"aleena-joy",fullName:"Aleena Joy"},{id:"201971",title:"Dr.",name:"Vidya",middleName:null,surname:"Mk",slug:"vidya-mk",fullName:"Vidya Mk"}]},{id:"55324",title:"The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer",slug:"the-role-of-androgens-in-ovarian-follicular-development-from-fertility-to-ovarian-cancer",totalDownloads:1755,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Androgens, steroid hormones produced by follicular cells, play a crucial role in the regulation of ovarian function. They affect folliculogenesis directly through androgen receptors (ARs) or indirectly through aromatization to estrogens. Androgens are thought to be primarily involved in preantral follicle growth and prevention of follicular atresia. It also seems possible that they are involved in the activation of primordial follicles. According to the World Health Organization, endocrine-disrupting chemicals (EDCs) are substances that alter hormonal signaling. EDCs comprise a wide variety of synthetic or natural chemicals arising from anthropogenic, industrial, agricultural, and domestic sources. EDCs interfere with natural regulation of the endocrine system by either mimicking or blocking the function of endogenous hormones as well as acting directly on gene expression or through epigenetic modifications. Disruptions in ovarian processes caused by EDCs may originate adverse outcomes such as anovulation, infertility, or premature ovarian failure. In this chapter, we aim to point out a possible involvement of androgen excess or deficiency in the regulation of ovarian function. We will summarize the effects of EDCs expressing antiandrogenic or androgenic activity on female physiology. Continuous exposition to even small concentration of such compounds can initiate oncogenesis within the ovary.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Malgorzata Duda, Kamil Wartalski, Zbigniew Tabarowski and\nGabriela Gorczyca",authors:[{id:"177042",title:"Ph.D.",name:"Malgorzata",middleName:null,surname:"Duda",slug:"malgorzata-duda",fullName:"Malgorzata Duda"},{id:"177918",title:"Dr.",name:"Zbigniew",middleName:null,surname:"Tabarowski",slug:"zbigniew-tabarowski",fullName:"Zbigniew Tabarowski"},{id:"205391",title:"MSc.",name:"Kamil",middleName:null,surname:"Wartalski",slug:"kamil-wartalski",fullName:"Kamil Wartalski"},{id:"205392",title:"MSc.",name:"Gabriela",middleName:null,surname:"Gorczyca",slug:"gabriela-gorczyca",fullName:"Gabriela Gorczyca"}]},{id:"56522",title:"Role of Melatonin in Reproductive Seasonality in Buffaloes",slug:"role-of-melatonin-in-reproductive-seasonality-in-buffaloes",totalDownloads:1726,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Buffaloes are characterized by seasonal reproductive activity. Anestrus buffalo heifers and lactating buffaloes were used to study the effect of melatonin treatment on the resumption of ovarian activity during out-of-breeding season. Buffaloes of treated group were injected or implanted with melatonin (18 mg melatonin/50 kg body weight). Using CIDR-eCG protocol preceded with melatonin successfully achieved estrus behavior and induced conception rate during out-of-breeding season. Furthermore, the reproductive performance of buffaloes during out-of-breeding season was clearly improved by melatonin implantation in conjunction with CIDR-eCG protocol due to the luteotrophic effect of melatonin expressed as increasing diameter of CL (corpus luteum) and progesterone concentration. This improvement resulted in greater values of conception rate, in melatonin implanted compared to not implanted buffaloes. Melatonin implantation in anestrus buffalo heifers increased the diameter of largest follicles and melatonin concentration but progesterone and luteinizing hormone (LH) concentrations were decreased. In addition, melatonin implantation in anestrus lactating buffaloes increased the SOD (superoxide dismutase) enzyme activity. Sustained release of exogenous melatonin significantly protects against oxidative stress while increasing beneficial total antioxidant capacity (TAC) concentration in summer-stressed anestrus buffaloes. Melatonin implantation in conjunction with CIDR-eCG protocol successfully improved some blood metabolites, in anestrus buffalo heifers during out-of-breeding season under tropical conditions.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Tamer Awad Ramadan",authors:[{id:"197651",title:"Dr.",name:"Tamer",middleName:"Awad",surname:"Ramadan",slug:"tamer-ramadan",fullName:"Tamer Ramadan"}]},{id:"54974",title:"Markers for Sperm Freezability and Relevance of Transcriptome Studies in Semen Cryopreservation: A Review",slug:"markers-for-sperm-freezability-and-relevance-of-transcriptome-studies-in-semen-cryopreservation-a-re",totalDownloads:1586,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"Advances in sperm assessment techniques have offered new perspectives to improve the technology of semen cryopreservation. This review addresses some recent achievements in the proteomics of seminal plasma and spermatozoa and exemplifies its importance as markers for sperm fertility following cryopreservation. Recent advances in transcriptome studies on sperm RNA-Seq data have generated new information aimed to unravel the physiological roles of RNAs in the sperm-egg fertilization processes and their associations with male fertility. The relevance of the sperm freezability markers and the potential associations of RNA-profiling sequences with the sperm biological functions have been discussed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Leyland Fraser",authors:[{id:"199650",title:"Dr.",name:"Leyland",middleName:null,surname:"Fraser",slug:"leyland-fraser",fullName:"Leyland Fraser"}]}],onlineFirstChaptersFilter:{topicId:"1384",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. 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Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR"},{id:"25",title:"Evolutionary Computation",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Artificial Intelligence",id:"14"},selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. 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