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Alireza Ziaei

Harvard Medical School

Dr. Alireza Ziaei, MD, is a physician-scientist at Harvard Medical School, Boston, USA. He is a recipient of numerous awards, including the National Excellent Researcher Award, National Young Investigator Award, and Science Excellence Prize. His main areas of interest are medical image processing and analysis, molecular basis and pathology pathways of ophthalmic disease, radiological detection, and image-guided therapy. He has considerable experience in biomedical research at Schepens Eye Research Institute, Massachusetts Eye and Ear, with a focus on corneal and ocular surface diseases, and at National Center for Image-Guided Therapy, Brain Tumor Consortium, and BCH Neuroimaging Center on radiological cancer detection at Harvard BWH/BCH hospitals. Dr. Ziaei’s seminal work has been recognized several times. He has published and presented numerous articles in highly ranked peer-reviewed journals and conferences worldwide. Dr. Ziaei has been a scientific member of the Association for Research in Vision and Ophthalmology (ARV), American Academy of Ophthalmology (AAO), International Society for Magnetic Resonance in Medicine (ISMRM), Radiological Society of North America (RSNA), International Society for Brain Mapping and Therapeutics (ISBMT), Tear Film and Ocular Surface Society (TFOS), and Massachusetts Medical Society (MMS). He serves as an executive editor, editorial board member, and scientific reviewer of reputed journals and scientific societies, including Nature International Journal of Science, Journal of Magnetic Resonance Imaging, Abdominal Radiology, Investigative Ophthalmology & Visual Science (IOVS), American Journal of Ophthalmology (AJO), Journal of Clinical & Experimental Ophthalmology, and Journal of Cell Biology.

2books edited

2chapters authored

Latest work with IntechOpen by Alireza Ziaei

Science and research have always been crucial to furthering our understanding of ophthalmic conditions and their treatment and prevention. Scientific achievements in ophthalmology have produced fundamental insights and opened up possibilities for improving human health. This book provides readers with a comprehensive overview of the latest and most advanced findings in several aspects of ophthalmic pathology, treatment, and surgical strategies, as well as in vision sciences and perception. Chapters cover such topics as acute hydrops, cataract treatments, keratoconus, surgical/non-surgical treatments in vision rehabilitation, and geometric analysis of ophthalmic lens.

Eyesight and Imaging

Eyesight and Imaging

Edited by Alireza Ziaei

Books edited

Frontiers in Ophthalmology and Ocular Imaging

Frontiers in Ophthalmology and Ocular Imaging

Edited by Alireza Ziaei

Chapters authored

Advances in Medical Imaging Technology for Accurate Detection of Prostate Cancer

By Alireza Ziaei

Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous male malignancy and one of the leading causes of cancer-related mortality in the United States. Biologic heterogeneity of PCa results is different presentations ranging from indolent to highly aggressive tumors with high morbidity and mortality. Due to this broad range of clinical behavior, it is required to differentiate clinically significant PCa (csPCa) tumors and reduce detection of indolent cancers. PCa is generally diagnosed with non-targeted systematic trans-rectal ultrasound (TRUS)-guided biopsy in patients with elevated prostate serum antigen (PSA) or abnormal digital rectal examination (DRE). Non-targeted systematic TRUS as the typical imaging modality for assessing the prostate, samples only a small part of the gland with a high possibly that the biopsy results may not catch the most aggressive tumor in the gland accurately. Multi-parametric (MP) magnetic resonance imaging (MRI), as the most specific and sensitive imaging modality in PCa management, has been reported to be the reference standard for prostate imaging endorsed. However, there are a variety of interpretive pitfalls, which have been reported to be encountered at mpMRI of the prostate. The purpose of this chapter is to provide a summary of the current advances in accurate detection of PCa.

Part of the book: Prostate Cancer

Immuno-Oncology, Imaging Biomarkers and Response to Chemotherapy in Cancer Treatment

By Alireza Ziaei and Forough Kheiry

Immuno-oncology is a young and growing field in cancer therapy. It stimulates immune system to target and attack the tumor or inhibiting the immune response. Recent findings in cancer immunotherapy has revealed that the immune system can control many cancers across various histologies, producing durable responses in a way which not seen with many small molecule drugs. Advances in understanding the role and molecular mechanisms of immunotherapy are revolutionizing clinical practice in cancer treatment. Immunotherapy is being intensively explored with the aim of improving primary response rates or prolonging overall survival. The purpose of this chapter is to review the different aspect of immunotherapy including blockade of immunological checkpoints, immuno-oncology and imaging biomarkers, immune response, therapeutic resistance and combination therapy, while several additional immuno-therapeutic strategies are also highlighted.

Part of the book: Translational Studies on Inflammation

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