Wounds due to surgical incisions and due to injuries often do not heal and can result in complications like slow healing and infections. Several approaches to facilitate wound healing are constantly being developed. Here we discuss various wounds and multiple ways to treat wounds especially those resulting from abdominal surgery either due to conventional surgery or due to laparoscopic surgery. In future, there are various possibilities in the pipeline that could result in accelerated wound healing as well as tissue regeneration.
Part of the book: Wound Healing
Wound healing is an active and compound biological course which can be divided into four steps: hemostasis, inflammation, proliferation, and remodeling. Diabetes mellitus induces weakened wound healing by disturbing one or more of the biological functions of these steps. Diabetic foot ulcers result from the simultaneous action of multiple disturbing causes. Mesenchymal stem cells, especially autologous ones, are easily accessible with noninvasive methods and have been shown to provide a regenerative microenvironment at wound sites. Despite current knowledge, major hurdles remain to be overcome in order to achieve effective therapeutic effects. Photobiomodulation is the use of light to reduce pain and inflammation and stimulate healing and the proliferation of stem cells, which would be very useful in increasing stem cell function and in regenerative medicine. The current study analyzes the results of studies using separate and combined administrations of stem cells and photobiomodulation on diabetic wound healing in patients and animal models. We hypothesize that the combined application of photobiomodulation and stem cells will accelerate the repair process and assist the healing of foot ulcers in diabetes mellitus patients.
Part of the book: Recent Advances in Wound Healing