Haisheng Yang

Beijing University of Technology China

Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.

1books edited

1chapters authored

Latest work with IntechOpen by Haisheng Yang

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

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Osteogenesis and Bone Regeneration

Edited by Haisheng Yang

Chapters authored

Multi-Scale Biomechanics of Osteoporotic Spine Fracture

By Haisheng Yang

Osteoporosis, the most common bone disorder found in the elderly, afflicts from 15 to 30% Caucasian women in US and results in an estimated 700,000 spine fractures per year. The prevalence of spine fractures in the elderly is high, ranging from 20 to 50%. Fractures are biomechanical events resulting from the load applied to a bone exceeding its ability to bear load. Osteoporotic spine fracture occurs owing to diminished vertebral microarchitecture and microfailure of bone tissues, ultimately leading to a compromised whole vertebral strength, and therefore, it is a multi-scale biomechanics event. In this chapter, insights into the micromechanics of the human vertebral body gained by micro-computed tomography (CT) and micro-finite element modeling will be reviewed. Following that, noninvasive assessment of vertebral strength using quantitative CT-based finite element analysis at a continuum level and its potential applications in improving spine fracture risk prediction in the clinic will be discussed.

Part of the book: Biomechanics

Haisheng Yang

Latest work with IntechOpen by Haisheng Yang

Osteogenesis and Bone Regeneration

Chapters authored

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