Electrodeposited thermoelectric material properties.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8448",leadTitle:null,fullTitle:"Glycerine Production and Transformation - An Innovative Platform for Sustainable Biorefinery and Energy",title:"Glycerine Production and Transformation",subtitle:"An Innovative Platform for Sustainable Biorefinery and Energy",reviewType:"peer-reviewed",abstract:"The increase in the amount of glycerin in the market is a burden for all producers, especially those operating in the biodiesel sector: reuse options are in fact limited for the management of this by-product. Glycerol enhancement has therefore become a priority to improve the sustainability of the biodiesel industry. Nevertheless, the multifunctionality of glycerol makes it a promising precursor for different types of production (fuel/biofuel, chemical products). This conversion has therefore become a subject of multifaceted research that requires an exchange of knowledge across many sectors. In this book, different disciplines (chemistry, biology, engineering, etc.) have been taken into consideration to propose an interdisciplinary point of view on different aspects.",isbn:"978-1-78984-691-1",printIsbn:"978-1-78984-690-4",pdfIsbn:"978-1-83962-179-6",doi:"10.5772/intechopen.78821",price:119,priceEur:129,priceUsd:155,slug:"glycerine-production-and-transformation-an-innovative-platform-for-sustainable-biorefinery-and-energy",numberOfPages:136,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"63834d3e01c2550240908758fb0fbe34",bookSignature:"Marco Frediani, Mattia Bartoli and Luca Rosi",publishedDate:"September 11th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8448.jpg",numberOfDownloads:7488,numberOfWosCitations:10,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:17,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:34,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 8th 2018",dateEndSecondStepPublish:"November 29th 2018",dateEndThirdStepPublish:"January 28th 2019",dateEndFourthStepPublish:"April 18th 2019",dateEndFifthStepPublish:"June 17th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"53209",title:"Prof.",name:"Marco",middleName:null,surname:"Frediani",slug:"marco-frediani",fullName:"Marco Frediani",profilePictureURL:"https://mts.intechopen.com/storage/users/53209/images/system/53209.jpg",biography:"Marco Frediani is Professor of Industrial Chemistry at the University of Florence, Department of Chemistry “Ugo Schiff,” Italy. He obtained his PhD under the supervision of both Dr. Claudio Bianchini, I.C.C.O.M., CNR, Florence, Italy and Prof. Dr. Walter Kaminsky, Insitute of Technical and Macromolecular Chemistry, University of Hamburg, Germany. His scientific interest focuses on catalysis for organic reactions of industrial relevance, polymer chemistry, and reuse of materials at the end of their life cycle by pyrolysis. He has presented at many international conferences, published more than seventy papers in international scientific journals, edited numerous books, and written more than fifteen book chapters. He also holds four patents.",institutionString:"University of Florence",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Florence",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"53215",title:"Dr.",name:"Luca",middleName:null,surname:"Rosi",slug:"luca-rosi",fullName:"Luca Rosi",profilePictureURL:"https://mts.intechopen.com/storage/users/53215/images/10495_n.jpg",biography:'Luca Rosi is Associate Professor of Industrial Chemistry at the \\"Ugo Schiff\\" Chemistry Department of the University of Florence. His scientific activity focuses mainly on the field of \\"homogeneous catalysis,\\" basically on the reactivity of the group VIII metal complexes (Ru, Co, Pd). He also deals with pyrolytic processes that adopt microwaves for the treatment of end-of-life polymeric materials (e.g., tires, post-consumer plastics, solid plastic waste, shredded mixtures, and waste electrical and electronic equipment) and/or biomass in order to convert them to useful products or fuels.',institutionString:"University of Florence",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Florence",institutionURL:null,country:{name:"Italy"}}},coeditorTwo:{id:"188999",title:"Dr.",name:"Mattia",middleName:null,surname:"Bartoli",slug:"mattia-bartoli",fullName:"Mattia Bartoli",profilePictureURL:"https://mts.intechopen.com/storage/users/188999/images/system/188999.png",biography:"Dr. Mattia Bartoli has always performed at the highest levels throughout his education and training, as proved by research outputs with several published peer-reviewed papers in top international journals. After obtaining his Ph.D., Dr. Bartoli moved to the Biorefinery Conversion Network, University of Alberta, Canada, where he contributed to developing new materials and new technologies. In 2018, he joined the Carbon Group, Polytechnic University of Turin, Italy, where he studied both the production and use of carbon from thermochemical conversion of waste streams for material science applications. Since 2021, Dr. Bartoli has been working on CO2 electrochemical and thermochemical conversion at the Center for Sustainable Future Technologies (CSFT@POLITO). He is also a member of several journal editorial boards and international societies.",institutionString:"Polytechnic University of Turin",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Polytechnic University of Turin",institutionURL:null,country:{name:"Italy"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"702",title:"Petrochemical Engineering",slug:"engineering-chemical-engineering-petrochemical-engineering"}],chapters:[{id:"68264",title:"Introductory Chapter: A Brief Insight about Glycerol",doi:"10.5772/intechopen.88062",slug:"introductory-chapter-a-brief-insight-about-glycerol",totalDownloads:746,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Mattia Bartoli, Luca Rosi and Marco Frediani",downloadPdfUrl:"/chapter/pdf-download/68264",previewPdfUrl:"/chapter/pdf-preview/68264",authors:[{id:"53209",title:"Prof.",name:"Marco",surname:"Frediani",slug:"marco-frediani",fullName:"Marco Frediani"},{id:"53215",title:"Dr.",name:"Luca",surname:"Rosi",slug:"luca-rosi",fullName:"Luca Rosi"},{id:"188999",title:"Dr.",name:"Mattia",surname:"Bartoli",slug:"mattia-bartoli",fullName:"Mattia Bartoli"}],corrections:null},{id:"66623",title:"Catalytic Dehydration of Glycerine to Acrolein",doi:"10.5772/intechopen.85751",slug:"catalytic-dehydration-of-glycerine-to-acrolein",totalDownloads:1458,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The biodiesel production yields glycerine as a by-product in quantities around 10 vol% of produced biodiesel. Acrolein can be obtained from glycerine by a dehydration reaction. Catalytic processes in gas phase have been developed to obtain acrolein from a renewable feedstock using heterogeneous catalysts. The main process variables are the reaction temperature, the concentration of glycerol in water, and the space velocity in fixed-bed reactors. A thermodynamic study of the equilibrium has been made to estimate the conversion to equilibrium as a function of temperature. The reactors have been heated usually between 523 and 603 K. Generally, an aqueous glycerol solution is preheated in a preheating zone at a temperature enough to vaporize the feedstock, between 473 and 533 K, depending on the concentration of reactant required in the feed. Some of the most active catalysts in the gas-phase reaction (yield >70%) were NH4-La-β zeolite, Pd/LaY zeolite, hierarchical ZSM-5, WO3/ZrO2, WO3/TiO2, ZrOx-NbOx, WOx-NbOx, WO3-SiO2/ZrO2, NbOx-WOx/Al2O3, H3PO4-MCM-41, SAPO-40, NbPSi, Pd-H3PW12O40/Zr-MCM-41, H3PW12O40/Cs-SBA-15, H3PW12O40/Nb2O5, Cs-doped H4SiW12O40/Al2O3, H4SiW12O40/TiO2, and H4SiW12O40/SiO2.",signatures:"Israel Pala Rosas, Jose Luis Contreras Larios , Beatriz Zeifert and José Salmones Blásquez",downloadPdfUrl:"/chapter/pdf-download/66623",previewPdfUrl:"/chapter/pdf-preview/66623",authors:[{id:"94936",title:"Dr.",name:"José Luis",surname:"Contreras",slug:"jose-luis-contreras",fullName:"José Luis Contreras"},{id:"284261",title:"Ph.D.",name:"Israel",surname:"Pala-Rosas",slug:"israel-pala-rosas",fullName:"Israel Pala-Rosas"},{id:"284262",title:"Dr.",name:"Jose",surname:"Salmones",slug:"jose-salmones",fullName:"Jose Salmones"},{id:"284263",title:"Dr.",name:"Beatriz",surname:"Zeifert",slug:"beatriz-zeifert",fullName:"Beatriz Zeifert"},{id:"295779",title:"Prof.",name:"Jose Luis",surname:"Contreras",slug:"jose-luis-contreras",fullName:"Jose Luis Contreras"}],corrections:null},{id:"66923",title:"Production of Solketal Using Acid Zeolites as Catalysts",doi:"10.5772/intechopen.85817",slug:"production-of-solketal-using-acid-zeolites-as-catalysts",totalDownloads:1164,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Commercial solketal is known as Augeo™ SL 191 and is produced by Rhodia (a member of the Solvay Group), which stands out as a slow evaporation solvent derived from glycerin which is considered a renewable source. It has low toxicity to human health and the environment. It is a good solvent for resins and polymers, replacing solvents derived from petroleum, and can be used as an additive of (bio) fuels. This work aimed to study acidy zeolites (H-BEA, H-MOR, H-MFI, and H-FER) as new heterogeneous catalysts of solketal production, through the ketalization reaction of glycerol with acetone. The catalytic activity showed H-BEA > H-MOR = H-MFI > H-FER after 180 min, in kinetics study. The major conversion was 85% for H-BEA. It was also verified that all the catalysts can be reused four times without washing or pretreatment among reactions in batch reactor. The solketal produced in this work was characterized by comparing it with its commercial standard, obtaining very similar characteristics.",signatures:"Vinicius Rossa, Gisel Chenard Díaz, Germildo Juvenal Muchave, Donato Alexandre Gomes Aranda and Sibele Berenice Castellã Pergher",downloadPdfUrl:"/chapter/pdf-download/66923",previewPdfUrl:"/chapter/pdf-preview/66923",authors:[{id:"197429",title:"Dr.",name:"Sibele",surname:"Pergher",slug:"sibele-pergher",fullName:"Sibele Pergher"},{id:"285323",title:"Dr.",name:"Vinicius",surname:"Rossa",slug:"vinicius-rossa",fullName:"Vinicius Rossa"},{id:"293254",title:"Ph.D. Student",name:"Germildo",surname:"Muchave",slug:"germildo-muchave",fullName:"Germildo Muchave"},{id:"293257",title:"Dr.",name:"Gisel Chenard",surname:"Díaz",slug:"gisel-chenard-diaz",fullName:"Gisel Chenard Díaz"},{id:"293258",title:"Dr.",name:"Donato Alexandre",surname:"Gomes Aranda",slug:"donato-alexandre-gomes-aranda",fullName:"Donato Alexandre Gomes Aranda"}],corrections:null},{id:"66787",title:"Enzymatic Synthesis of Functional Structured Lipids from Glycerol and Naturally Phenolic Antioxidants",doi:"10.5772/intechopen.85913",slug:"enzymatic-synthesis-of-functional-structured-lipids-from-glycerol-and-naturally-phenolic-antioxidant",totalDownloads:1247,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Glycerol is a valuable by-product in biodiesel production by transesterification, hydrolysis reaction, and soap manufacturing by saponification. The conversion of glycerol into value-added products has attracted growing interest due to the dramatic growth of the biodiesel industry in recent years. Especially, phenolic structured lipids have been widely studied due to their influence on food quality, which have antioxidant properties for the lipid food preservation. Actually, they are triacylglycerols that have been modified with phenolic acids to change their positional distribution in glycerol backbone by enzymatically catalyzed reactions. Due to lipases’ fatty acid selectivity and regiospecificity, lipase-catalyzed reactions have been promoted for offering the advantage of greater control over the positional distribution of fatty acids in glycerol backbone. Moreover, microreactors were applied in a wide range of enzymatic applications. Nowadays, phenolic structured lipids have attracted attention for their applications in cosmetic, pharmaceutical, and food industries, which definitely provide attributes that consumers will find valuable. Therefore, it is important that further research be conducted that will allow for better understanding and more control over the various esterification/transesterification processes and reduction in costs associated with large-scale production of the bioconversion of glycerol. The investigated approach is a promising and environmentally safe route for value-added products from glycerol.",signatures:"Jun Wang, Linlin Zhu, Jinzheng Wang, Yan Hu and Shulin Chen",downloadPdfUrl:"/chapter/pdf-download/66787",previewPdfUrl:"/chapter/pdf-preview/66787",authors:[{id:"286183",title:"Prof.",name:"Jun",surname:"Wang",slug:"jun-wang",fullName:"Jun Wang"},{id:"286992",title:"Ms.",name:"Linlin",surname:"Zhu",slug:"linlin-zhu",fullName:"Linlin Zhu"},{id:"286994",title:"Prof.",name:"Shulin",surname:"Chen",slug:"shulin-chen",fullName:"Shulin Chen"},{id:"292589",title:"MSc.",name:"Jinzheng",surname:"Wang",slug:"jinzheng-wang",fullName:"Jinzheng Wang"},{id:"292590",title:"Ms.",name:"Yan",surname:"Hu",slug:"yan-hu",fullName:"Yan Hu"}],corrections:null},{id:"66319",title:"Glycerol Transformation to Value-Added 1,3-Propanediol Production: A Paradigm for a Sustainable Biorefinery Process",doi:"10.5772/intechopen.83694",slug:"glycerol-transformation-to-value-added-1-3-propanediol-production-a-paradigm-for-a-sustainable-biore",totalDownloads:1485,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The impact of diminishing fossil fuel resources, rising environmental issues as well as the global demand for energy, fuels and chemicals has significantly directed to the use of renewable biomass for sustainable production of fuels and chemicals. Glycerol, a three carbon feedstock, is one of the most promising biomass resources which at present is obtained as a by-product in large quantities during the biodiesel production. This stimulated a lot of interest in developing new valorization technologies to produce high-value tonnage chemicals from glycerol by sustainable processes such as oxidation, dehydration, hydrogenolysis, steam reforming, carboxylation, acetalization, esterification and chlorination. In this chapter, we intend to focus on the hydrogenolysis of glycerol which produces important commodity chemicals such as propanediols, propanols and ethylene glycol. In particular, the selective hydrogenolysis of glycerol to 1,3-propanediol performed in both liquid phase and vapor phase reaction processes is described. Furthermore, the most significant progress in the development of the catalytic materials for glycerol hydrogenolysis including the reaction pathways is herein summarized.",signatures:"Shanthi Priya Samudrala",downloadPdfUrl:"/chapter/pdf-download/66319",previewPdfUrl:"/chapter/pdf-preview/66319",authors:[{id:"284730",title:"Dr.",name:"Priya",surname:"Samudrala",slug:"priya-samudrala",fullName:"Priya Samudrala"}],corrections:null},{id:"66682",title:"Glycerol as a Superior Electron Source in Sacrificial H2 Production over TiO2 Photocatalyst",doi:"10.5772/intechopen.85810",slug:"glycerol-as-a-superior-electron-source-in-sacrificial-h-sub-2-sub-production-over-tio-sub-2-sub-phot",totalDownloads:603,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Biodiesel fuel (BDF) has gained much attention as a new sustainable energy alternative to petroleum-based fuels. BDF is produced by transesterification of vegetable oil or animal fats with methanol along with the co-production of glycerol. Indeed, transesterification of vegetable oil (136.5 g) with methanol (23.8 g) was performed under heating at 61°C for 2 h in the presence of NaOH (0.485 g) to produce methyl alkanoate (BDF) and glycerol in 83.7 and 73.3% yields, respectively. Although BDF was easily isolated by phase separation from the reaction mixture, glycerol and unreacted methanol remained as waste. In order to construct a clean BDF synthesis, the aqueous solution of glycerol and methanol was subjected to sacrificial H2 production over a Pt-loaded TiO2 catalyst under UV irradiation by high-pressure mercury lamp. H2 was produced in high yield. The combustion energy (ΔH) of the evolved H2 reached 100.7% of the total ΔH of glycerol and methanol. Thus, sacrificial agents such as glycerol and methanol with all of the carbon attached to oxygen atoms can continue to serve as an electron source until their sacrificial ability was exhausted. Sacrificial H2 production will provide a promising approach in the utilization of by-products derived from BDF synthesis.",signatures:"Masahide Yasuda, Tomoko Matsumoto and Toshiaki Yamashita",downloadPdfUrl:"/chapter/pdf-download/66682",previewPdfUrl:"/chapter/pdf-preview/66682",authors:[{id:"153619",title:"Emeritus Prof.",name:"Masahide",surname:"Yasuda",slug:"masahide-yasuda",fullName:"Masahide Yasuda"},{id:"269599",title:"Dr.",name:"Tomoko",surname:"Matsumoto",slug:"tomoko-matsumoto",fullName:"Tomoko Matsumoto"},{id:"285216",title:"Prof.",name:"Toshiaki",surname:"Yamashita",slug:"toshiaki-yamashita",fullName:"Toshiaki Yamashita"}],corrections:null},{id:"67455",title:"Inclusion of Crude Glycerin in Diets for Sheep",doi:"10.5772/intechopen.86683",slug:"inclusion-of-crude-glycerin-in-diets-for-sheep",totalDownloads:788,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Crude glycerin is the main by-product of biodiesel industry. It has a great potential for reducing the feed costs in ruminant feedlot systems without affecting animal health and performance, mainly as a replacement for conventional food energy sources, such as corn grain. In the past years, great advancements have been achieved with crude glycerin utilization. This by-product is mainly composed of glycerol, an energetic compound of great assimilation by rumen microorganisms, being extensively metabolized in the liver. Recent studies with ovine species have demonstrated that high concentrations of glycerol (more than 76% of crude glycerin) can be used without detrimental effect for animals. In the rumen, glycerol is rapidly metabolized by microorganisms to form volatile fatty acids (VFA), mainly propionate and butyrate. In this way, glycerol constitutes an excellent substrate for gluconeogenesis and animal energy generation. At present, the inclusion of up to 20% of dry matter (DM) in a total diet seems to be the most interesting strategy, as it promotes greatest animal performance. However, other studies suggest that high inclusions of crude glycerin (30% of dry matter) could be possible depending on market price and the structure of farm operation, with favorable economic results.",signatures:"Marco Túlio Costa Almeida and Josimari Regina Paschoaloto",downloadPdfUrl:"/chapter/pdf-download/67455",previewPdfUrl:"/chapter/pdf-preview/67455",authors:[{id:"284230",title:"Ph.D.",name:"Marco",surname:"Almeida",slug:"marco-almeida",fullName:"Marco Almeida"},{id:"284244",title:"Dr.",name:"Josimari",surname:"Paschoaloto",slug:"josimari-paschoaloto",fullName:"Josimari Paschoaloto"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2288",title:"Crude Oil Emulsions",subtitle:"Composition Stability and Characterization",isOpenForSubmission:!1,hash:"d237bdec7bb1475639149b044fac69f5",slug:"crude-oil-emulsions-composition-stability-and-characterization",bookSignature:"Manar El-Sayed Abdel-Raouf",coverURL:"https://cdn.intechopen.com/books/images_new/2288.jpg",editedByType:"Edited by",editors:[{id:"102626",title:"Prof.",name:"Manar El-Sayed",surname:"Abdel-Raouf",slug:"manar-el-sayed-abdel-raouf",fullName:"Manar El-Sayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1604",title:"Advances in Chemical Engineering",subtitle:null,isOpenForSubmission:!1,hash:"88084d0ed8f82a4ec50ed554de9f0036",slug:"advances-in-chemical-engineering",bookSignature:"Zeeshan Nawaz and Shahid Naveed",coverURL:"https://cdn.intechopen.com/books/images_new/1604.jpg",editedByType:"Edited by",editors:[{id:"15484",title:"Dr",name:"Zeeshan",surname:"Nawaz",slug:"zeeshan-nawaz",fullName:"Zeeshan Nawaz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2873",title:"Hydrogen Storage",subtitle:null,isOpenForSubmission:!1,hash:"5636fb7f125524c17e174c9cf62c8363",slug:"hydrogen-storage",bookSignature:"Jianjun Liu",coverURL:"https://cdn.intechopen.com/books/images_new/2873.jpg",editedByType:"Edited by",editors:[{id:"145203",title:"Prof.",name:"Jianjun",surname:"Liu",slug:"jianjun-liu",fullName:"Jianjun Liu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5143",title:"Chemical Enhanced Oil Recovery (cEOR)",subtitle:"a Practical Overview",isOpenForSubmission:!1,hash:"a0b7842ba790370b5485de1694611376",slug:"chemical-enhanced-oil-recovery-ceor-a-practical-overview",bookSignature:"Laura Romero-Zeron",coverURL:"https://cdn.intechopen.com/books/images_new/5143.jpg",editedByType:"Edited by",editors:[{id:"109465",title:"Dr.",name:"Laura",surname:"Romero-Zerón",slug:"laura-romero-zeron",fullName:"Laura Romero-Zerón"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6730",title:"Palm Oil",subtitle:null,isOpenForSubmission:!1,hash:"96d058f3abbc8d0660dcd56042a8ece8",slug:"palm-oil",bookSignature:"Viduranga Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/6730.jpg",editedByType:"Edited by",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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Adhesive bonding is a recent technology that in many applications, can replace the techniques already known in engineering, such as rivets, bolts, welds, etc. The adhesives have the advantage of being lightweight. The use of adhesives in engineering is already present in several areas, for example, aeronautics, nautical, renewable energy, mechanics, etc.
\r\n\tAs the subject of adhesives is in constant development, this book's purpose is to get together information about adhesives science and technology, recent advances, and applications that use adhesive technology. Also, to make these contents available to engineering students, engineers, researchers, and the people interested in this topic. The book is expected to present works that aim to contribute to the development of new technologies and the use of non-traditional materials in engineering.
The considerable growth of research studies in energy-harvesting technologies, such as solar energy harvesting [1], RF power harvesting [2], thermoelectric-generator-based electrolyte [3], thermoelectric-generator-based solid thermoelectric materials [4], associated with the Internet of Things (IoT) leads to more demands in the development of the high performance of a micro-thermoelectric generator (TEG). Micro-TEG keeps a role as a charger to the rechargeable battery of IoT sensing systems or even replaces the battery if micro-TEG with high performance is employed. The TEG utilizes the Seebeck effect that can convert thermal energy into electricity. The TEG has many advantages, including small size, without moving parts, free from noise, greenhouse gases, and long-term operation time [5, 6]. A voltage will be generated once a temperature difference across the micro-TEG is provided.
To enhance the performance of the micro-TEG, high-performance thermoelectric materials and increasing the number of thermoelectric elements are vital factors. Regarding thermoelectric materials, until now, several thermoelectric materials have been studied, including organic materials (metalloporphyrin/single-walled carbon nanotube composite films [7], Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate [8], and compositions of conducting polymers and metal nanoparticles [9]) and inorganic materials (nanoporous silicon [10], cobalt triantimonide [11], bismuth telluride and antimony telluride [12], tin selenide [13], electrodeposited bismuth telluride [14]). Among them, thermoelectric-materials-based BiTe are widely investigated because of their high performance for applications at near room temperature. For synthesis of thermoelectric-materials-based BiTe, several methods have been reported, including thermally evaporated method [15], metal organic chemical vapor deposition method [16], and pulsed laser melting method [17]. Electrochemical deposition is one of the preferred ways to enable the deposited film with high-quality morphology and compactness. Moreover, the electrodeposition method is capable of modifying the morphology, composition, and crystal structure of the synthesized film, which would result in the high performance of the deposited materials. Concerning enhancing the integration density, hundreds of thermoelectric elements could be produced on a small footprint by utilizing micro/nano fabrication technologies; however, some issues still remain. For instance, a complex process is required to create the air bridge between two thermoelectric elements. High contact resistance between thermoelectric elements and substrate results in low-performance micro-TEG. The performance of thermoelectric materials is degraded during their fabrication of the micro-TEG. The height of the thermoelectric element is limited by micro/nano fabrication technology. Thus, it makes micro-TEG low performance and against the practical applications.
In this work, we review the recent progress in the micro-TEG, including material synthesis, device fabrication, and application demonstration. Various high-performance thermoelectric materials synthesized by the electrodeposition method, including thick bulk-like thermoelectric material, Pt nanoparticles embedded in a thermoelectric material, and Ni-doped thermoelectric material, are presented. In addition, the fabrication of micro-TEGs based on micro/nano fabrication technology as well as assembly technology is demonstrated. The performance of the fabricated micro-TEG is compared with other related works. Moreover, the fabricated micro-TEG as a power source for a calculator and a twist watch has been investigated.
The Seebeck coefficient is defined as the harvested voltage from the temperature difference across the thermoelectric materials. Its standard unit is microvolts per kelvin (μV/K). The Seebeck coefficient may exhibit positive or negative signs, which represents p-type or n-type thermoelectric materials, respectively. The p-type thermoelectric material shows an excess of holes, while the n-type thermoelectric material possesses an excess of free electrons. When a temperature difference appears at the ends of the thermoelectric material block, the charge carriers (electrons or holes) move from the hot side to the cold side, causing a thermoelectric voltage. The following equation depicts the Seebeck coefficient
where
One factor affecting the Seebeck coefficient is charge carrier concentration
where
Electrical conductivity is an essential electrical property for thermoelectric material to conduct an electrical current. Electrical conductivity and electrical resistivity are the reciprocals of each other. Macroscopically, electrical conductivity is related to the dimensions and resistance of the measured thermoelectric material, which can be calculated by the following equation:
where
In principle, the electrical resistivity of a material characterizes the ability of the material to interrupt electricity flow. Therefore, it is strongly related to the flow of electrons and holes in a material. Those two factors influence the value of electrical conductivity, as shown in the following equation,
where
The thermal conductivity
where
Equation of lattice thermal conductivity can be referred to the following relationship.
where
Equation of charge-carriers thermal conductivity is estimated by
where
The figure of merit
To obtain high ZT values of thermoelectric materials, high
A TEG is a solid device, which is able to convert thermal energy into electricity or vice versa. It consists of n and p-type thermoelectric elements arranged electrically in series and thermally in parallel. A cross-sectional view and titled view of the TEG structure are shown in Figure 1(a) and (b), respectively. It mainly consists of n- and p-type thermoelectric elements, a metal bar, and a substrate.
TEG structure. (a) Cross-sectional view. (b) Titled view.
As mentioned previously, the p-type element has a positive Seebeck coefficient and an excess of holes
The resistance of the thermoelectric elements is estimated by:
where
In the above Eq. (10), the electrical contact resistance is eliminated. However, this resistance is typically quite difficult to be negligible due to the fabrication process. Therefore, the electrical contact resistance
The generated voltage
where n is the number of thermoelectric elements,
The maximum electrical output power of the TEG can be calculated by using Eq. (13), which is obtained if a load resistance
where
Several factors could affect the performance of the TEGs. Thermoelectric materials with excellent characteristics, including a high Seebeck coefficient, a small electrical resistivity, and a low thermal conductivity, are always desired for enhancing the TEG’s performance. Many novel approaches, including utilizing metal nanoparticles [24], nanoporous materials [25], carbon black particles [26], and metal doping [27, 28], have been investigated to improve thermoelectric material’s properties. Besides the effects of material properties, selecting proper physical dimensions of thermoelectric elements, such as the width and height of thermoelectric elements, could also contribute to better performance of the TEG [28]. Also, increasing the number of thermoelectric elements would be a valuable method for improving the performance of the TEG, as shown in Eq. (13).
The formula of an electrical energy conversion efficiency
where
Thermoelectric materials presented in this work are synthesized by the conventional three-electrode system, which is controlled electrochemically by a potentiostat. The system involves a working electrode, a counter electrode, and a reference electrode. A silicon wafer with Cr-Au layers on the top insulated by SiO2 layer is employed as a working electrode, while a Pt strip and Ag/AgCl with 3 M KCl solution are utilized as counter and reference electrodes. The synthesized material is formed on the working electrode caused by the oxidation–reduction (redox) reaction. The electrochemical deposition mechanism is quite complicated and has been presented in many publications [30, 31]. It can be summarized as follows. In the electrolyte, the absorbed atom is in the form of the hydrated matter, which is stripped at the interface between the solution and the cathode. Then, it combines with other absorbed atoms to form a new nucleus. This process continues and contributes to the further growth of the deposited material.
One of the benefits of the electrodeposition method is the ability to change the morphology, composition, and crystal structure of deposited film by adjusting certain parameters in the electrodeposition system. All the changes might influence the alteration of the electronic or/and thermal properties of the deposited film. The effectively applied potential on the working electrode is one of the important parameters in the electrodeposition system that reflect on the variation of the current density. A change of the over potential on the electrode normally affects the current density and a chance to change the morphology.
As mentioned in the introduction section, thermoelectric materials could be synthesized by several methods. Although high performance of thin-film thermoelectric materials has been achieved, the TEG produced by thin-film thermoelectric materials possesses a low output power. Once the height of thermoelectric elements is low (a few micrometer heights), it is hard to create a large temperature difference across the TEG device. Thus, its output voltage, as well as output power, is in small value. The evidence could be easily seen via Eqs. (12) and (13). Although an output power of the TEG-utilized thin films could be enhanced by a novel design for heat transfer in a lateral direction, TEG’s output power is still not enough for realistic applications. Therefore, a thick film of thermoelectric material with high Seebeck, large electrical conductivity, and low thermal conductivity are always desired to achieve high-performance micro-thermoelectric generators. Typically, thick thermoelectric material films could be formed by a screen printing method, a powder synthesis and sintering method, and a mechanical alloying and spark plasma sintering method; nevertheless, these methods have at least the following disadvantages, such as poor mechanical strength, a high fabrication cost, and low material performance. Herein, we present the thick and stable thermoelectric films synthesized by electrodeposition.
Figure 2 shows the sample preparation process for material synthesis and material evaluation. It starts from a silicon substrate with a thickness of 300 μm (Figure 2(a)). On top of this substrate, a SiO2 layer with a thickness of 200 nm is deposited by a plasma-enhanced chemical vapor deposition (PECVD) employing TEOS (TetraEthOxySilan Si (OC2H5)4), as shown in Figure 2(b). Next, Cr-Au layers with a thickness of 20 nm and 150 nm are formed on the SiO2 layer by the sputtering method, respectively (Figure 2(c)). The thermoelectric material is subsequently deposited by the electrodeposition method, as discussed in Section 3.1 (Figure 2(d)). Because a material property evaluation needs to be conducted on an insulating substrate to avoid short-circuiting, the synthesized films are peeled off from the substrate by epoxy resin, as shown in Figure 2(e) and (f). Figure 2(g) and (h) show the electrodeposited thermoelectric material (Bi2Te3) on the silicon substrate and transferred thermoelectric material on epoxy, respectively.
Sample preparation process. (a) Silicon. (b) SiO2 deposition. (c) Cr-Au deposition. (d) Thermoelectric material formed by electrodeposition. (d) Epoxy coating. (f) Sample for evaluation.
Figure 3(a) and (b) show the electrodeposited thermoelectric materials by constant and pulsed conditions, respectively. As can be seen that, the constant electrodeposited film (Figure 3(a)) exhibits an initial 4 μm-thick compact layer while the top layer includes pillar structures. Although the thick-film thermoelectric material can be achieved by further deposition, its mechanical strength is very weak due to its porous structure. The thick electrodeposited film by the constant condition is easily peeled off for substrate. To overcome this problem, pulsed electrodeposition has been conducted. Compared with the constant electrochemical deposition, the pulsed electrodeposition with a pulse delay time for the recovery of the ion concentration always leads to a crystalline structure with high orientation and good uniformity [32]. This is proven in Figure 3(b). The deposited surface under pulsed conditions is more uniform and smoother than that under constant conditions. Figure 3(c) shows a representative cross-sectional SEM image of the 600 μm-thick Bi2Te3 electrodeposited film, which is comparable to the bulk Bi2Te3 material. Consequently, by using simple and low-cost electrochemical deposition technique, thick bulk-like thermoelectric material posing a highly compact and uniform appearance could be achieved.
Thermoelectric material. (a) Constant deposition. (b) Pulsed deposition. (c) A 600 μm-thick Bi2Te3 electrodeposited film.
Thermoelectric material properties, including Seebeck coefficient and electrical resistivity, are evaluated, as shown in Table 1. The pulsed deposited film has a higher Seebeck coefficient as well as lower electrical resistivity than those of the constant deposited film. The power factor for pulsed deposited material is 3.2 × 10−4 W/mK2 while it is 0.5 × 10−4 W/mK2 for constant deposited material. Moreover, an annealing process has been performed to enhance the characteristics of the electrodeposited thermoelectric materials. The highest Seebeck coefficient is found at the annealing temperature of 250°C. The details of measurement setup and evaluation results can be found in [33].
Constant electrodeposition | Pulsed electrodeposition | |||
---|---|---|---|---|
Nonannealing | Annealing (250°C) | Nonannealing | Annealing (250°C) | |
Seebeck coefficient (±20 μV/K) | −50 | −110 | −80 | −150 |
Electrical resistivity (±5 μΩm) | 50 | 20 | 20 | 15 |
Power factor (W/mK2) | 0.5 × 10−4 | 6 × 10−4 | 3.2 × 10−4 | 15 × 10−4 |
Electrodeposited thermoelectric material properties.
In summary, thick bulk-like thermoelectric material based on the electrochemical deposition technique has been demonstrated. The electrodeposited film possesses a highly compact and uniform surface. The electrodeposited material properties by pulsed deposition are much higher than those by constant deposition. Also, thermoelectric performances of the electrodeposited film enhanced by the annealing process have been investigated.
Metal nanoparticle inclusion in the nanocomposite process is one of the promising methods to enhance the figure of merit
Figure 4(a) shows the surface morphology of the electrodeposited pure Bi2Te3 with its crystal as plate-like structure. The surface morphology has been modified by the inclusion of Pt nanoparticles in the Bi2Te3, as shown in Figure 4(b). The crystal grain size of Pt- Bi2Te3 composite is smaller than that of pure Bi2Te3, as can be seen in Figure 4(a) and (b). Thus, the electrodeposited film with Pt nanoparticles tends to form lower porosity and denser surface structure in comparison to pure Bi2Te3. A high-resolution transmission electron microscopy image of Pt- Bi2Te3 composite is shown in Figure 4(c), where black areas represent the Pt nanoparticles.
(a) Electrodeposited surface of Bi2Te3. (b) Electrodeposited surface of Pt-Bi2Te3. (c) High resolution of TEM image of Pt-Bi2Te3.
Table 2 shows the average grain size calculated by identifying FWHM and Integral Breadth
Electrodeposited films | Deposited Pt (wt%) | Integral Breadth, | Average grain size (nm) |
---|---|---|---|
Bi2Te3 | 0.0 | 0.6 × 10−2 | 32.2 ± 4.3 |
Pt/Bi2Te3 -I | 1.0 | 1.6 × 10−2 | 13.9 ± 3.4 |
Pt/Bi2Te3 -II | 1.5 | 2.2 × 10−2 | 10.9 ± 1.3 |
Pt/Bi2Te3 -III | 1.9 | 3.8 × 10−2 | 7.9 ± 0.1 |
Average grain size on Bi2Te3 and Pt-Bi2Te3 nanocomposite films at 2
The summary of characteristic of the synthesized films is shown in Table 3. Experimental results indicate that once the grain size decreases, the carrier concentration becomes lower. The lowest carrier concentration is observed for 1.9 wt% Pt-Bi2Te3 composite in comparison with others, including Bi2Te3, 1.5 wt% Pt-Bi2Te3, and 1.0 wt% Pt-Bi2Te3. As mentioned in Section 2, the Seebeck coefficient and electrical conductivity are trade-off, and they strongly depend on the carrier concentration. Lower carrier concentration results in a higher Seebeck coefficient but causes the smaller electrical conductivity, which agrees with the observation in this work, as given in Table 3.
Electrodeposited films | Average grain size (nm) | Electrical conductivity(S/cm) | Seebeck coefficient (μV/K) | Carrier concentration, |
---|---|---|---|---|
Bi2Te3 | 36.5 | 618.7 | −115.2 | 6.21 |
Pt (1.0 wt.%)/Bi2Te3 | 17.3 | 704.3 | −152.1 | 2.40 |
Pt (1.5 wt.%)/Bi2Te3 | 12.1 | 643.7 | −166.6 | 2.02 |
Pt (1.9 wt.%)/Bi2Te3 | 7.80 | 527.8 | −184.1 | 1.93 |
Summary characteristics of the synthesized films.
Figure 5 shows the measurement result of the thermal conductivity of the electrodeposited film. The thermal conductivity decreases as the Pt nanoparticle concentration increases. The main reason is due to a reduction of the phonon mean free path caused by phonon grain boundary scattering [37]. The scattering mechanism of mid- to long-wavelength of phonons in the Pt-Bi2Te3 nanocomposite can be imagined via Figure 5(b). Short-wavelength phonons are scattered by imperfections such as atomic defects and stacking defects while the Pt nanoparticles and grain boundaries are effective at scattering the mid-to long-wavelength phonon. A close adjacent between the Pt nanoparticles also contributed to the phonon scattering effect by reducing the phonon mean free path. Based on measurement results, including Seebeck coefficient, electrical conductivity, and thermal conductivity, the maximum ZT for Pt-Bi2Te3 nanocomposite is found at 0.61, which is 300% higher than that of the electrodeposited pure Bi2Te3. The details of evaluation setup, measurement results, and other discussions can be found in [24].
Thermal conductivity and ZT as a function of Pt nanoparticle concentration. (b) Illumination of phonon scattering mechanisms in the Pt-Bi2Te3 nanocomposite.
In summary, Pt-Bi2Te3 nanocomposite has been synthesized successfully by the electrochemical deposition technique. It is found that as higher Pt nanoparticles are deposited in the nanocomposite film, the grain size becomes smaller and the nanostructure experienced significant defects. The change of grain size could be a help to adjust the trade-off between Seebeck coefficient and electrical conductivity, which results in the highest power factor. In addition, the defects caused by Pt nanoparticle benefit the phonon scattering enhancement, thus lowering the thermal conductivity. Consequently, the ZT can be improved.
Although the thick-film thermoelectric materials have been investigated successfully, as described in Section 3.2, further investigations are still required to enhance their thermoelectric characteristics. Moreover, in order to open an opportunity for mass production, highly scalable synthesis electrodeposition on a large wafer size for thermoelectric materials should be conducted. In this section, a novel process technology for the ultra-thick film as well as high-performance characteristics (high Seebeck coefficient, large electrical conductivity, and low thermal conductivity) is investigated. Both electrodeposited films, including pure Bi2Te3 and Ni-doped Bi2Te3, reaching in mm-order thickness, have been synthesized, evaluated, and compared. Moreover, a highly scalable electrodeposition process for large wafer size has been performed and proven.
Figure 6(a) and (b) show the surface crystal structure of the electrodeposited pure Bi2Te3 and Ni-doped Bi2Te3, respectively. As can be seen that the crystal grain size of pure Bi2Te3 is much larger than that of Ni-doped Bi2Te3. The selected area electrode diffraction patterns for pure Bi2Te3 and Ni-doped Bi2Te3 are shown in Figure 6(c) and (d), respectively. Diffraction spots in Figure 6(c) and (d) indicate that both electrodeposited films pose polycrystalline structures. In quantitative comparison, the spots in Figure 6(d) are much more than those in Figure 6(c). One possible cause is the grain size effects. Decreasing the grain size results in an increase of the boundary scattering and lattice defects, as discussed in Section 3.3. Thereby, not only the trade-off between Seebeck coefficient and electrical conductivity could be adjusted (changing the carrier concentration), but also the thermal conductivity gets lower due to photon scattering.
SEM image of pure Bi2Te3. (b) SEM image of Ni doped Bi2Te3. (c) Selected area electron diffraction pattern of pure Bi2Te3. (c) Selected area electron diffraction pattern of pure Ni-doped Bi2Te3.
Figure 7(a) shows the experimental result of the highly scalable synthesis process, which is performed on a 4-inch wafer size. The deposited film reaches 2 mm thickness with a high uniform surface, as shown in Figure 7(b). The success of the highly scalable electrodeposition could open up the opportunity for mass production to reduce the fabrication cost.
(a) Electrodeposition on 4-inch wafer size. (b) SEM image of the cross-sectional view of the electrodeposited film.
Summary characteristics of the electrodeposited thermoelectric materials can be found in Table 4. Experimental results show that 0.7 at% Ni-doped Bi2Te3 has the highest Seebeck coefficient as well as largest electrical conductivity compared with others, including pure Bi2Te3, 0.3 at% Ni-doped Bi2Te3, 1.0 at% Ni-doped Bi2Te3, and 1.5 at% Ni-doped Bi2Te3. Although the thermal conductivity of 0.7 at% Ni-doped Bi2Te3 is not the smallest one, its thermal conductivity is two times smaller than that of the pure Bi2Te3. The ZT of Ni-doped Bi2Te3 is estimated as 0.78, which is five times larger than that of the pure Bi2Te3. The details of evaluation setup, and measurement results, and other discussions can be found in [38, 39].
Seebeck coefficient (μV/K) | Electrical conductivity (S/cm) | Power factor (μV/m.K2) | Thermal conductivity (W/m.K) | Figure of merit | |
---|---|---|---|---|---|
Pure Bi2Te3 | −115 ± 5 | 525 ± 10 | 694 | 1.3 ± 0.1 | 0.15 ± 0.05 |
0.3 at% Ni-Bi2Te3 | −130 ± 5 | 885 ± 30 | 1496 | 0.8 ± 0.05 | 0.61 ± 0.1 |
0.7 at% Ni-Bi2Te3 | −143 ± 4 | 975± 15 | 2050 | 0.76 ± 0.09 | 0.78 ± 0.1 |
1.0 at% Ni-Bi2Te3 | −125 ± 5 | 675± 70 | 1054 | 0.62 ± 0.04 | 0.52 ± 0.12 |
1.5 at% Ni-Bi2Te3 | −130 ± 10 | 575 ± 75 | 972 | 0.56 ± 0.06 | 0.5 ± 0.18 |
Summary characteristics of the electrodeposited thermoelectric materials.
One of the challenges for micro-TEG is the small harvested temperature difference across the module, thus resulting in low output power. In the conventional design of micro-TEG, the heat flows in the vertical direction (thermoelectric elements such as column structure); therefore, ultra-height thermoelectric elements are typically needed. However, to fabricate micro-TEG based on micro/nano technologies, the height of thermoelectric elements is limited to a hundred micrometers due to the limitation of the photoresist thickness and a patterning aspect ratio. To overcome this issue, thermoelectric elements are proposed to be laid in a lateral direction instead of a vertical one. The proposed structure for micro-TEG is shown in Figure 8(a), which consists of n- and p-types thermoelectric elements (Bi2Te3 and Sb2Te3), copper heat guide, and PDMS (polydimethylsiloxane) as a base material. This micro-thermoelectric generator possesses a flexible characteristic that can be utilized in wearable electronic applications. The heat flow direction is shown in Figure 8(b).
(a) Proposed micro-thermoelectric generator structure. (b) Heat flow in lateral direction.
Figure 9 shows the fabrication process for micro-TEG, which begins with a silicon wafer. The SiO2 with 500 nm thickness and Cr-Au layers with 10 nm thickness and 150 nm thickness, respectively, are deposited on the top of the silicon wafer, respectively, by PECVD and sputtering methods (Figure 9(a)). The thermoelectric materials are selectively deposited on the Au surface by electrodeposition technique via the patterned photoresist with a thickness of 100 μm (Figure 9(b)). Next, Ti-TiN-Au-Cu layer as a barrier contact layer is formed by sputter via a stencil mask, as shown in Figure 9(c)–(e). The copper heat guides are subsequently grown on the barrier contact layer by the electroplating method (Figure 9(f)). The front side of micro-TEG is then filled by PDMS (Figure 9(g)). To create the heat guide from backside, a deep reactive ion etching (RIE) is conducted (Figure 9(g)). A thermal glue with high thermal conductivity is refilled into the molds by a screen printing technique (Figure 9(h)). The remaining silicon layer is etched out by plasma etching, and SiO2 and Cr-Au layers are removed by the ion beam milling technique (Figure 9(i)). Finally, PDMS is filled into the backside cavities (Figure 9(k)).
Fabrication process. (a) SiO2-Cr-Au deposition. (b) Thermoelectric material synthesis. (c) Photolithography process. (d, e) Multilayers of barrier metal contacts of Ti-TiN-Au-Cu. (f) Copper heat guides. (g) PDMS refilling and Si-SiO2 removing processes; (h) screen printing process of thermal conductive glue. (i) Backside etching process; (k) PDMS refilling process.
Figure 10(a) shows the fabricated micro-TEG based on micro/nano fabrication technologies. The micro-TEG contains 24 pairs of electrodeposited n- and p-type thermoelectric materials integrated on 1 cm2. The output power density of the fabricated micro-TEG is displayed in Figure 10(b), which reaches 3 μW/cm2 under a temperature difference caused by human body (37°C) and ambient environment (15°C) using natural convection. The details of evaluation setup, measurement results, and other discussions can be found in [40].
(a) Fabricated micro-TEG. (b) Applied temperature and output power.
In summary, a novel design and fabrication process for the micro-TEG have been proposed and investigated. Micro-TEG has been fabricated successfully by micro/nano fabrication technologies. Also, its performance has been evaluated. Although the power density of the fabricated micro-TEG is small, it could be improved by increasing the density of n- and p-types thermoelectric elements. The idea and experimental results in this work may be useful for applications in wearable electronic devices.
To improve the performance of the micro-TEG, enhancing the performance of the thermoelectric materials is a critical point. Another important point is an increase in the number of thermoelectric elements, which can significantly enhance output voltage and output power, as discussed by Eqs. (12) and (13). Thus, the power density can be significantly increased. High-density n- and p-type thermoelectric elements could be formed on a small foot print by utilizing the micro/nano fabrication technologies, as discussed in Section 4.1 and in Refs. [41, 42]. However, some issues need to be addressed, as follows. Complex processes, including photolithography, etching, deposition, and lift-off processes, are needed to construct the air bridge between thermoelectric elements. Therefore, the fabrication time is long, and the cost is high. Moreover, the bonding strength between thermoelectric elements and substrate is weak; thereby, the internal resistance of the fabricated micro-TEG is high, caused by the large contact resistance. Such issues make the performance of the micro-TEG low, which is against it for realistic applications. In this section, a novel method to produce the micro-TEG based on ultra-thick and dense electrodeposited thermoelectric material (presented in Section 3.4) and assembly technique is proposed and investigated.
To fabricate a high-density micro-TEG, small thermoelectric elements are needed, which are prepared as follows. The 4-inch electrodeposited wafer (Figure 11(a)) is diced into many small elements (Figure 11(b)). It is noted that before cutting, Ni-Au layers as barrier contact layers are formed on both sides of the wafer by electroplating method [43, 44] to decrease the ohmic contact resistance between thermoelectric elements and substrate. Figure 11(c) shows the magnified image of the diced thermoelectric elements with dimensions of 0.4 mm × 0.4 mm × 2 mm.
(a) Four-inch electrodeposited thermoelectric material wafer. (b) Thermoelectric elements with dimensions of 0.4 mm × 0.4 mm × 2 mm. (e) Close-up image of thermoelectric elements.
The fabrication process for the micro-TEG based on the assembly technique is shown in Figure 12(a)–(c). The SiO2 layer as an insulator layer is formed on a silicon wafer by PECVD, and Cr-Au layers are deposited on the SiO2 layer by the sputtering method, as given in Figure 12(a). Cr-Au layers are patterned to form the bottom interconnection by a wet etching method [45, 46], as shown in Figure 12(b). Next, thermoelectric elements are aligned and bonded on the substrate by conductive glue. Finally, a top wafer cover is aligned and bonded on top of the thermoelectric elements (Figure 12(c)). Because the thermoelectric elements are pretty small, the process for vertical alignment becomes difficult. To overcome this issue, a stencil silicon wafer with patterned through holes is proposed, and a simple metal holder tool is employed to fix and align the stencil wafer and substrate, as shown in Figure 12(d). Thermoelectric elements are inserted into holes of the stencil wafer. Figure 12(e) shows the experimental image after the thermoelectric elements are bonded on the substrate. The completely fabricated micro-TEG is shown in Figure 12(f). In total, 127 pairs, including n- and p-type thermoelectric elements, are formed successfully on a small footprint of 15 mm2. Thus, although a simple assembly technique is employed, the integration density of thermoelectric elements could be comparable to the micro-fabrication of the micro-TEG.
Fabrication process and fabricated micro-TEG. (a) Silicon substrate with SiO2 and Cr-Au layers on top. (b) Cr-Au patterning. (c) TEG schematic. (d) Device fabrication setup including holders, substrate, and stencil wafer. (e) After the first alignment and bonding. (f) Completely fabricated device.
The fabricated micro-TEG shows a high output power of 33.9 mW and a large power density of 15.1 mW/cm2 under a temperature difference across the micro-TEG of 75 °C, which is much higher performance than those of other published works [42, 47, 48, 49, 50, 51]. More comparisons to other works are shown in Table 5. The details of evaluation setup, measurement results, and other discussions can be found in [52].
Pairs | Height (mm) | Temperature difference ∆T (°C) | Open circuit (V) | Internal resistance (Ω) | Power (mW) | Power density (mW/cm2) | References |
---|---|---|---|---|---|---|---|
24 | 0.2 | 24 | 0.05 | 200 | — | 0.004 | [47] |
6 | 0.0015 | 6 | 0.036 | 25 | 0.0023 | — | [48] |
71 | 0.0135 | 39 | 0.2 | 134 | 2.4 | 2.4 | [49] |
127 | 0.01 | 52.5 | 0.3 | 13 | 3 | 9.2 | [50] |
200 | 0.02 | 88 | 0.5 | 45.2 | — | 1.04 | [42] |
220 | 2 | 40 | 2.1 | — | 7 | 1.75 | [51] |
127 | 2 | 75 | 2.2 | 35 | 33.9 | 15.1 | This work [52] |
Comparison of TEG performance.
In summary, the high integration density of the micro-TEG has been demonstrated by utilizing a simple assembly technique. Micro-TEG consisting of 127 pairs is successfully fabricated on 15 mm2. The fabricated micro-TEG possesses a high performance, which may satisfy the demand for being a reliable power source for electronic devices.
Although a high output voltage and output power could be achieved by the fabricated micro-TEG, a high thermal source is needed. In turn to low-thermal sources, its output power is in small value, which cannot be used as a power source for electronic devices. To overcome this issue, a DC-DC converter is required, which amplifies the output voltage of the micro-TEG from an mV range to V range of the output of the DC-DC converter. Thus, this makes micro-TEG possible for powering electronic devices with low-power consumption. In this section, the micro-TEG for powering calculator and twist watch is demonstrated. A DC-DC converter is utilized to boost the output voltage of the micro-TEG up to sufficient levels to store in an energy-storable unit, which is subsequently supplied to electronic devices. The energy storable unit can be a capacitor, a supercapacitor, or a rechargeable battery. We have developed successfully micro-supercapacitors-based graphene nanowalls with PANI in liquid state [53] and solid state [54] and with MnO2 [55]. Although these micro-supercapacitors show a high charge and discharge processes, their storable energy is lower than that of commercial rechargeable battery. In this section, a rechargeable battery from Enercera [56] is employed for the application demonstration. Two applications utilizing the micro-TEG are conducted, as follows.
Figure 13(a) illustrates the experimental setup for the micro-TEG as a power source for the calculator. It consists of Peltier (as a heat source), copper blocks, temperature sensors, the DC-DC converter, a rechargeable battery, and a calculator. The harvester energy is accumulated and stored in the rechargeable battery via the DC-DC converter and then supplied to electronic devices. Figure 13(b) shows the output of DC-DC converter over the temperature difference across the micro-TEG. The experimental results indicated that output of DC-DC converter reaches 2.8 V at ∆ T = 2°C and 4 V at T = 8°C. Figure 13(c) shows the rechargeable battery characteristic, which increases from 0 V to 1.8 V, taking approximately 8 minutes. Figure 13(d) shows the demonstration of using micro-TEG as an electrical power source for the calculator. The calculator can be powered on and used once the rechargeable battery gets over 1.5 V.
(a) Experimental setup for powering portable electronic device. (b) DC-DC output as a function of temperature difference. (c) Battery charged up by the micro-TEG. (d) Micro-TEG as a power source for calculator.
Figure 14(a) illustrates the experimental setup for powering a twist watch. One side of the micro-TEG is in contact with human skin while another side is attached to the backside of the twist watch. α-Gel is pasted on both sides of the micro-TEG to enhance heat transfer between interfaces. The DC-DC converter and rechargeable battery are employed, which are similar to those mentioned in Section 5.1. The DC-DC converter, rechargeable battery, and micro-TEG are arranged on the twist watch, as shown in Figure 14(b). Figure 14(c) shows the output of the micro-TEG and battery charge when twist watch is worn. It takes approximately 5 minutes for the rechargeable battery to reach 1.2 V. With this energy, the twist watch is powered on and runs.
(a) Experimental setup for powering wearable electronic device. (b) The photo of the self-powered twist watch. (c) TEG output and battery charge-up.
Demonstrated results in this section indicate a high potential using the micro-TEG for powering not only portable electronic devices but also wearable electronic devices. Further integrated functions, including sensing (humidity, temperature, gases, etc.), displaying (screen display), and transmitting (radio frequency, Bluetooth, etc.) functions, should be investigated to produce a smart system for using in wireless IoT sensing systems.
In this work, not only basic knowledge about thermoelectric generators but also experiences on material synthesis, device fabrication, and application demonstration are reported. By investigating electrochemical deposition, high-performance thermoelectric materials have been achieved. Three kinds of high-performance thermoelectric materials, including thick bulk-like thermoelectric material, Pt nanoparticles embedded in a thermoelectric material, and Ni-doped thermoelectric material, are reported and discussed. Besides the material synthesis, novel fabrication methods can also help increase the output power and the power density of the micro-TEG significantly. Two fabrication processes, micro/nano fabrication technology and assembly technology, are investigated to produce high-performance micro-TEG. Moreover, the fabricated micro-TEG is successfully demonstrated for powering portable and wearable electronic devices. The contents of this paper are based on our experimental research. It is our hope that this review may be a useful reference for those working in the field of thermal-to-electric energy conversion, especially on the micro-TEG.
Part of this work was performed in the Micro/Nanomachining Research Education Center (MNC) of Tohoku University. This work was supported by Cabinet Office, Government of Japan, Cross-ministerial Strategic Innovation Promotion Program (SIP), (funding agency: The New Energy and Industrial Technology Development Organization, NEDO) and also supported in part by JSPS KAKENHI for Young Scientists (Grant number: 20K15147).
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Chemical modification reviewed includes chemical modification without introducing new atom such as cyclized natural rubber and deproteinized natural rubber (DPNR), modification by introducing a chemical group such as hydrogenated natural rubber (HNR), chlorinated natural rubber (CNR) and epoxidized natural rubber (ENR) and lastly modification by grafting on NR. Grafting can be carried out using DPNR latex to yield styrene‐grafted‐NR, methyl methacrylate‐grafted‐NR and styrene and methyl methacrylate‐grafted‐NR. The NR derivatives are reviewed in terms of their preparation, mechanism, properties and applications.",book:{id:"5919",slug:"elastomers",title:"Elastomers",fullTitle:"Elastomers"},signatures:"Azanam Shah Hashim and Siew Kooi Ong",authors:[{id:"200848",title:"Prof.",name:"Azanam Shah",middleName:null,surname:"Hashim",slug:"azanam-shah-hashim",fullName:"Azanam Shah Hashim"},{id:"205691",title:"Dr.",name:"Siew Kooi",middleName:null,surname:"Ong",slug:"siew-kooi-ong",fullName:"Siew Kooi Ong"}]}],onlineFirstChaptersFilter:{topicId:"153",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82212",title:"Protein Prenylation and Their Applications",doi:"10.5772/intechopen.104700",signatures:"Khemchand R. Surana, Ritesh B. Pawar, Ritesh A. Khairnar and Sunil K. 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Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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