Chapters authored
Infection by Salmonella enterica Promotes or Demotes Tumor Development
Cancer is a disease that claims the lives of millions of people every year around the world. To date, multiple risk factors that may contribute to its development have been described. In recent years, a factor that has been associated to cancer development is the presence of bacterial infections that could contribute to its occurrence not only by favoring the inflammatory process, but also through the release of proteins that trigger tumorigenesis. One of the bacterial species that have recently generated interest due to its possible role in cancer development is Salmonella enterica. Nevertheless, for more than a decade, attenuated strains of Salmonella enterica have been proposed as a treatment for different neoplasms due to its bacterium tropism for the tumor microenvironment, its oncolytic activity and its ability to activate the innate and adaptive immune responses of the host. These two facets of Salmonella enterica are addressed in detail in this chapter, allowing us to understand its possible role in cancer development and its well-documented antitumor activity.
Part of the book: Salmonella
Role of the Microbiome as the First Metal Detoxification Mechanism
Exposure to environmental toxins in water, soil and air are increasing with health effects, mainly in older ages and physiological states (childhood and pregnancy). The role of the microbiota has been widely studied with effects on the maintenance of health but this is only possible with a diet that promotes it. The traditional Mexican diet is rich in fiber, which has prebiotic effects and has found a higher excretion of arsenic and fluoride in adolescents who maintained a diet high in fiber derived from traditional foods. After several descriptive studies in the state of Guanajuato, since 2004, first with arsenic in drinking water in population of several communities, in 2015, it is achieved through an intervention study with a supplementation of several vitamins and minerals in population adolescent, a greater urinary arsenic and fluoride excretion, as well as a greater consumption of traditional foods such as beans, bananas, orange and quelites. Food is key to maintain a function of the microbiota, so its review and study should be encouraged.
Part of the book: Prebiotics and Probiotics