Mahmoud Ahmed Mansour

King Saud bin Abdulaziz University for Health Sciences

Mahmoud Mansour PhD, is a professor of Biochemistry at Pharmaceutical Sciences Department, College of Pharmacy King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. His specialization includes molecular biology, biochemical pharmacology, pharmacogenetics and biochemistry. His research fields are biochemical pharmacological studies in cancers (especially hepatic cancer), antioxidants, oxidative stress, proteasome (and its role in the treatment of hepatic cancer), experimental gastroenterology, clinical gastroenterology and diabetes. He published more than 60 papers in peer-reviewed journals. He received State Encouragement award from Scientific Research Academy, (1998). Fourteen of his students were appointed as full university professors in Egypt, and Saudi Arabia.

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Latest work with IntechOpen by Mahmoud Ahmed Mansour

Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases.

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