Mahmoud Ahmed Mansour

King Saud bin Abdulaziz University for Health Sciences

Prof. Mahmoud Mansour is a Professor of Biochemistry at the College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. He received a pharmacy degree from Al-Azhar University Cairo, Egypt, in 1984, and a Ph.D. in Clinical Biochemistry from the Karolinska Institute, Stockholm, Sweden in 1992. As a fellow, Prof. Mansour contributed significantly to defining some aspects of the molecular biology of tissue injury and induction of lever toxicity and renal toxicity, with a focus on the role of antioxidants in the prevention and treatment of different toxic effects. In addition, he contributed significantly to developing a new strategy for tumors, especially those in the liver. His research has shown that proteasome inhibitors play an important role in preventing carcinogenesis of the liver by metastatic tumors. At King Saud bin Abdulaziz University for Health Sciences, Prof. Mansour continued to work on the pathogenesis of cancer and on issues concerning the cellular and molecular mechanisms of cancer biology and the metastatic process. He is currently conducting studies on liver cancer using the oncogene Gankyrin.

Mahmoud Ahmed Mansour

3books edited

1chapters authored

Latest work with IntechOpen by Mahmoud Ahmed Mansour

Oxidoreductase enzymes are a group of enzymes that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. Oxidoreductase enzymes utilize NADP+ or NAD+ as cofactors. Oxidoreductase enzymes include the following: oxidase, dehydrogenase, peroxidase, hydroxylase, oxygenase, and reductase. Most oxidoreductase enzymes are dehydrogenases. However, reductases are also common. The accepted nomenclature for dehydrogenases is “donor dehydrogenase”, where the donor is the oxidized substrate. Metabolic abnormalities disorders resulting from a deficiency (quantitative and qualitative) or from over-activity of oxidoreductase, which may contribute to the decreased normal performance of life, are becoming common. This book covers the potential applications of oxidoreductases on the growth of oxidoreductase-based diagnostic tests and better biosensors in the design of inventive systems for crucial co-enzyme generations and in the synthesis of polymers and organic substrates. The book describes the role of oxidoreductase as essential in medical drug formation. It can be employed to produce a huge amount of compounds that act as medical mediators like Cephalosporin (beta lactam antibiotic). Furthermore, the idea of how to use different enzymes as targets for medical treatment in different types of cancers is also described in this book.

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