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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"8094",leadTitle:null,fullTitle:"Aflatoxin B1 Occurrence, Detection and Toxicological Effects",title:"Aflatoxin B1 Occurrence, Detection and Toxicological Effects",subtitle:null,reviewType:"peer-reviewed",abstract:"This book consists of 11 chapters, divided into four parts. The chapters are written by experts in the field of aflatoxins. Select topics are presented here to provide a snapshot of current understanding of the occurrence and metabolism of aflatoxin B1, the contamination, exposure, and detection of aflatoxin B1, and the toxicological effects and detoxification of aflatoxin. The book is intended for students and scientists working in the field of aflatoxins.",isbn:"978-1-83880-256-1",printIsbn:"978-1-83880-255-4",pdfIsbn:"978-1-83880-183-0",doi:"10.5772/intechopen.77925",price:119,priceEur:129,priceUsd:155,slug:"aflatoxin-b1-occurrence-detection-and-toxicological-effects",numberOfPages:220,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"44f4ad52d8a8cbb22ef3d505d6b18027",bookSignature:"Xi-Dai Long",publishedDate:"June 3rd 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8094.jpg",numberOfDownloads:9470,numberOfWosCitations:5,numberOfCrossrefCitations:9,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:26,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:40,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 4th 2019",dateEndSecondStepPublish:"August 29th 2019",dateEndThirdStepPublish:"October 28th 2019",dateEndFourthStepPublish:"January 16th 2020",dateEndFifthStepPublish:"March 16th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"202142",title:"Prof.",name:"Xi-Dai",middleName:null,surname:"Long",slug:"xi-dai-long",fullName:"Xi-Dai Long",profilePictureURL:"https://mts.intechopen.com/storage/users/202142/images/system/202142.jpeg",biography:"Prof. Long Xi-Dai is a lecturer at Youjiang Medical University for Nationalities and Shanghai Jiao Tong University, China. He started his teaching career at Youjiang Medical University for Nationalities, Bose, in 2004. He obtained his PhD degree in Tumor Pathology at the Shanghai Jiao Tong University, Shanghai, China. His research focuses on the analysis of aflatoxin toxification and detection, hepatocellular carcinoma genetics, molecular mechanisms, epidemiology, and tumor susceptibility. His current research interests focus on the association between aflatoxins and hepatocarcinoma. He has more than 50 publications, serves on the editorial boards of seven journals, and regularly reviews for 25 journals and five granting bodies. His achievements have been recognized by several awards and honors, including Shanghai Shu-Guang Scholar, Guangxi Specially-invited Expert, and Guangxi Zhouyue Scholar.",institutionString:"Youjiang Medical University for Nationalities",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Macau",institutionURL:null,country:{name:"Macau"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1209",title:"Mycotoxicology",slug:"mycotoxicology"}],chapters:[{id:"69028",title:"Aflatoxin B1: Chemistry, Environmental and Diet Sources and Potential Exposure in Human in Kenya",doi:"10.5772/intechopen.88773",slug:"aflatoxin-b1-chemistry-environmental-and-diet-sources-and-potential-exposure-in-human-in-kenya",totalDownloads:1394,totalCrossrefCites:0,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Cancer incidences and mortality in Kenya are increasing according to recent reports and now number among the top five causes of mortality in the country. The risk factors responsible for this increase in cancer incidences are assumed to be genetic and/or environmental in nature. The environmental factors include exposure to carcinogenic contaminants such aflatoxins (AFs). However, the exact causes of the increase in cancer incidences and prevalence in many developing countries are not fully known. Aflatoxins are known contaminants produced by the common fungi Aspergillus flavus and the closely related Aspergillus parasiticus which grow as moulds in human foods. Aflatoxin B1 (AFB1) is most common in food and is 1000 times more potent when compared with benzo(a)pyrene, the most potent carcinogenic polycyclic aromatic hydrocarbon (PAH). Aflatoxins have therefore drawn a lot of interest in research from food safety and human health point of view. In this chapter, the chemistry, synthesis, identification, toxicology and potential human health risks of AFB1 in Kenya are discussed.",signatures:"Joseph Owuor Lalah, Solomon Omwoma and Dora A.O. Orony",downloadPdfUrl:"/chapter/pdf-download/69028",previewPdfUrl:"/chapter/pdf-preview/69028",authors:[{id:"301744",title:"Dr.",name:"Joseph",surname:"Lalah",slug:"joseph-lalah",fullName:"Joseph Lalah"}],corrections:null},{id:"68560",title:"Aflatoxin Occurrence in Dairy Feeds: A Case of Bulawayo, Zimbabwe",doi:"10.5772/intechopen.88582",slug:"aflatoxin-occurrence-in-dairy-feeds-a-case-of-bulawayo-zimbabwe",totalDownloads:865,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Aflatoxin contamination in feeds used by Bulawayo peri-urban farmers for dairy cows was assessed. Semi-intensive farming was the most common farming type practised by the farmers where the animal feeds were supplemented with mixed rations, concentrated feed, grass and brewers’ spent grains. Mixed ration was the most commonly used feed supplement. Feed analysis by high-performance liquid chromatography (HPLC) showed the presence of all four naturally occurring aflatoxins: aflatoxins B1, B2, G1 and G2. Total aflatoxin concentration in the feeds ranged from 0 to 250.9 μg/kg. Mixed ration had the highest average total aflatoxin concentration of 29.0 μg/kg, which is above the European Union (EU) standard adopted by Zimbabwe. AFB1, the most potent aflatoxin was the predominant aflatoxin across all feeds with an average concentration of 9.0 μg/kg and highest concentration of 149.6 μg/kg in a mixed ration sample which is also above the EU 5.0 μg/kg for lactating cows. Farm personnel responses to the questionnaire showed that most of them were not aware of aflatoxins. These findings call for stringent measures to be put in place with regard to aflatoxin testing in feeds for the dairy sector as well as educating the farmers on the importance of aflatoxin monitoring feed ingredients and livestock feeds.",signatures:"Nancy Nleya, Lubanza Ngoma and Mulunda Mwanza",downloadPdfUrl:"/chapter/pdf-download/68560",previewPdfUrl:"/chapter/pdf-preview/68560",authors:[{id:"301995",title:"Dr.",name:"Nancy",surname:"Nleya",slug:"nancy-nleya",fullName:"Nancy Nleya"},{id:"301999",title:"Prof.",name:"Mulunda",surname:"Mwanza",slug:"mulunda-mwanza",fullName:"Mulunda Mwanza"},{id:"302000",title:"Dr.",name:"Lubanza",surname:"Ngoma",slug:"lubanza-ngoma",fullName:"Lubanza Ngoma"}],corrections:null},{id:"67677",title:"α-Amylase Production by Toxigenic Strains of Aspergillus and Penicillium",doi:"10.5772/intechopen.86637",slug:"-amylase-production-by-toxigenic-strains-of-em-aspergillus-em-and-em-penicillium-em-",totalDownloads:644,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Aflatoxins are produced by a variety of fungal species and these have contributed to devastating health problems globally. However, apart from the capability of the production of aflatoxins, the productions of enzymes by like fungi have been explored. Aflatoxin B1-producing-toxigenic strains of Aspergillus flavus (A1), Aspergillus parasiticus (A2), Penicillium citrinum (P1) and Penicillium rubrum (P2) isolated from rice were grown on a defined medium with varying carbon and nitrogen sources. They were also grown on rice as sole carbon and nitrogen source for fungal growth. In an attempt to purify, the extracellular α-amylases produced were subjected to ammonium sulfate precipitation (40–90% saturation) followed by dialysis. The aflatoxin B1-producing toxigenic strains of Aspergillus flavus (A1), Aspergillus parasiticus (A2), Penicillium citrinum (P1) and Penicillium rubrum (P2) were able to produce α-amylases in both the growth medium with varying C and N sources of fungal and also in the rice medium. The most active α-amylase activity was produced by toxigenic A. flavus (A1) with a value of 3.25 ± 0.15 Units and this was when ammonium sulfate was nitrogen source with starch as carbon source of fungal growth in the defined growth medium. These toxigenic fungal strains can be explored for the industrial production of α-amylases.",signatures:"Adekunle Odunayo Adejuwon and Victoria Anatolyivna Tsygankova",downloadPdfUrl:"/chapter/pdf-download/67677",previewPdfUrl:"/chapter/pdf-preview/67677",authors:[{id:"301722",title:"Prof.",name:"Adekunle Odunayo",surname:"Adejuwon",slug:"adekunle-odunayo-adejuwon",fullName:"Adekunle Odunayo Adejuwon"},{id:"301726",title:"Prof.",name:"Victoria Anatolyivna",surname:"Tsygankova",slug:"victoria-anatolyivna-tsygankova",fullName:"Victoria Anatolyivna Tsygankova"}],corrections:null},{id:"68377",title:"Prevention by Essential Oils of the Occurrence and Growth of Aspergillus flavus and Aflatoxin B1 Production in Food Systems: Review",doi:"10.5772/intechopen.88247",slug:"prevention-by-essential-oils-of-the-occurrence-and-growth-of-em-aspergillus-flavus-em-and-aflatoxin-",totalDownloads:550,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Aspergillus flavus has been reported to be one of the most common fungal species in foods. Under conditions of high humidity and moderate temperature, this fungus may synthetize the mycotoxin Aflatoxin B1 (AFB1), which is reported to be hepatotoxic, teratogenic, mutagenic and immunosuppressive to human beings and livestock and it is classified as carcinogenic to humans (Group 1 by IARC). AFB1 affects cereals, oilseeds, nuts, spices, legumes, and dried fruits, while Aflatoxin M1 is a metabolite of AFB1 that can occur in milk and milk products. Current control is aimed at controlling fungal growth and AFB1 production in food by eco-friendly, biodegradable and safer alternatives, in contrast to synthetic chemicals that can be toxic to humans and cause adverse environmental effects. Recently, considerable attention has been directed towards natural compounds, such as essential oils (EOs) as a promising approach for controlling AFB1 production in food. The main reason for supporting the application of natural products is the consumer’s preference for natural methods to preserve foods. The aim of the present review is to summarize knowledge of EOs and AFB1 production from the literature.",signatures:"Yamina Ben Miri, Azem Belasli, Djamel Djenane and Agustín Ariño",downloadPdfUrl:"/chapter/pdf-download/68377",previewPdfUrl:"/chapter/pdf-preview/68377",authors:[{id:"58638",title:"Dr.",name:"Agustin",surname:"Ariño",slug:"agustin-arino",fullName:"Agustin Ariño"},{id:"245549",title:"Prof.",name:"Djamel",surname:"Djenane",slug:"djamel-djenane",fullName:"Djamel Djenane"},{id:"302571",title:"Ph.D.",name:"Yamina",surname:"Ben Miri",slug:"yamina-ben-miri",fullName:"Yamina Ben Miri"}],corrections:null},{id:"70550",title:"A New Approach for Detection of Aflatoxin B1",doi:"10.5772/intechopen.90403",slug:"a-new-approach-for-detection-of-aflatoxin-b1",totalDownloads:627,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Aflatoxin B1 (AFB1) is harmful to human health, mainly resulting from its toxic effects on the liver. AFB1 can lead to liver cell necrosis, hemorrhage, fibrosis, cirrhosis, etc. Acute AFB1 exposure at high levels can lead to hepatitis, whereas chronic exposure can result in liver cancer. In the past decades, a series of methods and techniques for detecting AFB1, including enzyme-linked immunosorbent assay (ELISA), high-performance liquid chromatography (HPLC), and thin-layer chromatography (TLC), have been developed. This study reviewed the detection methods of AFB1 and the corresponding utilization and summarizes all methods for evaluating the toxification of AFB1.",signatures:"Xing-Zhi-Zi Wang",downloadPdfUrl:"/chapter/pdf-download/70550",previewPdfUrl:"/chapter/pdf-preview/70550",authors:[{id:"302368",title:"Dr.",name:"Xing-Zhizi",surname:"Wang",slug:"xing-zhizi-wang",fullName:"Xing-Zhizi Wang"}],corrections:null},{id:"69361",title:"The Blood AFB1-DNA Adduct Acting as a Biomarker for Predicting the Risk and Prognosis of Primary Hepatocellular Carcinoma",doi:"10.5772/intechopen.88666",slug:"the-blood-afb1-dna-adduct-acting-as-a-biomarker-for-predicting-the-risk-and-prognosis-of-primary-hep",totalDownloads:498,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Aflatoxin B1 (AFB1) is an important carcinogen for primary hepatocellular carcinoma (PHCC). However, the values of blood AFB1-DNA adducts predicting HCC risk and prognosis have not still been clear. We conducted a hospital-based case-control study, consisting of 380 patients with pathologically diagnosed PHCC and 588 controls without any evidence of liver diseases, to elucidate the associations between the amount of AFB1-DNA adducts in the peripheral blood and the risk and outcome of HCC. All subjects had not the history of hepatitis B and C virus infection. AFB1-DNA adducts were tested using enzyme-linked immunosorbent assay. Cases with PHCC featured an increasing blood amount of AFB1-DNA adducts compared with controls (2.01 ± 0.71 vs. 0.98 ± 0.63 μmol/DNA). Increasing adduct amount significantly grew the risk of PHCC [risk values, 1.82 (1.34–2.48) and 3.82 (2.71–5.40) for medium and high adduct level, respectively]. Furthermore, compared with patients with low adduct level, these with medium or high adduct level faced a higher death and tumor-recurrence risk. These results suggest that the blood AFB1-DNA adducts may act as a potential biomarker for predicting the risk and prognosis of PHCC.",signatures:"Qin-Qin Long, Xiao-Qin Wu and Jin-Guang Yao",downloadPdfUrl:"/chapter/pdf-download/69361",previewPdfUrl:"/chapter/pdf-preview/69361",authors:[{id:"202471",title:"Dr.",name:"Jin-Guang",surname:"Yao",slug:"jin-guang-yao",fullName:"Jin-Guang Yao"},{id:"308890",title:"Dr.",name:"Qin-Qin",surname:"Long",slug:"qin-qin-long",fullName:"Qin-Qin Long"},{id:"308891",title:"Dr.",name:"Xiao-Qin",surname:"Wu",slug:"xiao-qin-wu",fullName:"Xiao-Qin Wu"}],corrections:null},{id:"68699",title:"The Toxic Effects of Aflatoxin B1: An Update",doi:"10.5772/intechopen.88775",slug:"the-toxic-effects-of-aflatoxin-b1-an-update",totalDownloads:1111,totalCrossrefCites:1,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Aflatoxin B1 (AFB1) is the most toxic in aflatoxin family. It is well known for its involvement in hepatic carcinogenesis. Other adverse effects include immune weakness, reproduction deficiency, malnutrition, and growth impairment. The key mechanism of AFB1 carcinogenesis is supposed to be epoxidation, which produce the AFB1-8,9-epoxide (AFBO) strongly adductive to DNA molecules. Other metabolites like AFM1, AFH1, and AFL, which retain DNA adductive capability, extend its toxicity. Scientists now found that AFB1 also affected epigenetic regulation, which might shed new light into AFB1 toxicity mechanism researches. The detoxification of AFB1 has always been a hot spot in AFB1-related studies. The major methods can be categorized into physical treatment, biological treatment, chemical treatment, combination strategy, and sorbent additives. None of the methods is 100% perfect, however considering economic factors, simplicity, effectiveness, safety, and preservation of the food nutrition. This review will discuss the toxicity and toxic mechanisms of AFB1. Also, detoxification of AFB1 will be reviewed.",signatures:"Yuhua Shan",downloadPdfUrl:"/chapter/pdf-download/68699",previewPdfUrl:"/chapter/pdf-preview/68699",authors:[{id:"302719",title:"Dr.",name:"Yuhua",surname:"Shan",slug:"yuhua-shan",fullName:"Yuhua Shan"}],corrections:null},{id:"68549",title:"The Carcinogenicity of Aflatoxin B1",doi:"10.5772/intechopen.88353",slug:"the-carcinogenicity-of-aflatoxin-b1",totalDownloads:853,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Aflatoxins are a class of carcinogenic mycotoxins, products of Aspergillus fungi, which are known contaminants in a large portion of the world’s food supply. Aflatoxin B1 (AFB1) is the most potent toxin, which has been strongly linked to the development of hepatocellular carcinoma (HCC), especially given coinfection with hepatitis B virus (HBV). AFB1 is catalyzed by cytochrome P450 (CYP450) into aflatoxin B1-8,9-exo-epoxide to form DNA adducts, which leads to carcinogenesis by disrupting DNA repair. AFB1-induced DNA damage is also caused by the production of excessive ROS, leading to the oxidation of DNA bases. The majority of AFB1-related to HCC carry G-to-T transversion of p53 gene. When the p53 gene is mutated, it shows a “gain of oncogenic function.” In addition, epigenetic alterations may potentially be beneficial for the treatment of HCC, because the epigenetic changes are reversible. This chapter will provide important information on the carcinogenicity of AFB1, including DNA damage checkpoint response and epigenetic alteration.",signatures:"Jie Li and Mengxi Liu",downloadPdfUrl:"/chapter/pdf-download/68549",previewPdfUrl:"/chapter/pdf-preview/68549",authors:[{id:"301700",title:"Dr.",name:"Jie",surname:"Li",slug:"jie-li",fullName:"Jie Li"}],corrections:null},{id:"69074",title:"X-Ray Repair Cross Complementing 4 (XRCC4) Genetic Single Nucleotide Polymorphisms and the Liver Toxicity of AFB1 in Hepatocellular Carcinoma",doi:"10.5772/intechopen.88752",slug:"x-ray-repair-cross-complementing-4-xrcc4-genetic-single-nucleotide-polymorphisms-and-the-liver-toxic",totalDownloads:649,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Our previous reports have shown that the genetic single-nucleotide polymorphisms (GSNPs) in the DNA repair gene X-ray repair cross complementing 4 (XRCC4) are involved in the carcinogenesis of hepatocellular carcinoma (HCC) induced by aflatoxin B1 (AFB1). However, the effects of GSNPs in the coding regions of XRCC4 on hepatic toxicity of AFB1 have been less investigated. We conducted a hospital-based clinic tissue samples with pathologically diagnosed HCC (n = 380) in a high AFB1 exposure area to explore the possible roles of GSNPs in the coding regions of XRCC4 in AFB1-induced HCC using liver toxicity assays. A total of 143 GSNPs were included in the present study and genotyped using the SNaPshot method, whereas the liver toxicity of AFB1 was evaluated using AFB1-DNA adducts in the tissues with HCC. In the clinicopathological samples with HCC, the average adduct amount is 2.27 ± 1.09 μmol/mol DNA. Among 143 GSNPs of XRCC4, only rs1237462915, rs28383151, rs762419679, rs766287987, and rs3734091 significantly increased the levels of AFB1-DNA adducts. Furthermore, XRCC4 GSNPs (including rs28383151, rs766287987, and rs3734091) also increased cumulative hazard for patients with HCC. These results suggest that the liver toxicity of AFB1 may be modified by XRCC4 GSNPs.",signatures:"Yan Deng, Xue-Min Wu, Xiao-Ying Huang and Xi-Dai Long",downloadPdfUrl:"/chapter/pdf-download/69074",previewPdfUrl:"/chapter/pdf-preview/69074",authors:[{id:"202142",title:"Prof.",name:"Xi-Dai",surname:"Long",slug:"xi-dai-long",fullName:"Xi-Dai Long"},{id:"202469",title:"Dr.",name:"Xue-Min",surname:"Wu",slug:"xue-min-wu",fullName:"Xue-Min Wu"},{id:"202470",title:"Dr.",name:"Xiao-Ying",surname:"Huang",slug:"xiao-ying-huang",fullName:"Xiao-Ying Huang"},{id:"307675",title:"Dr.",name:"Yan",surname:"Deng",slug:"yan-deng",fullName:"Yan Deng"}],corrections:null},{id:"68690",title:"Decontamination of Aflatoxin B1",doi:"10.5772/intechopen.88774",slug:"decontamination-of-aflatoxin-b1",totalDownloads:1001,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Aflatoxins are a class of highly toxic carcinogenic mycotoxins by food contaminant Aspergillus fungi: Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are classified into four compounds: aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), and aflatoxin G2 (AFG2), while AFB1 is the most potent carcinogenic agent associated with hepatocellular carcinoma (HCC). Aspergillus fungi is ubiquitously found in the soil and contaminates the crops such as maize, groundnuts, rice, and so on. Prevention of aflatoxin contamination, detection and degradation of Aspergillus fungi contamination, and the concentration of AFB1 in the foodstuffs are of the primary task to prevent health problems from aflatoxin. Here, the different ways are summarized to degrade or decontaminate the aflatoxins available with the foods. Traditional decontamination of aflatoxin includes physical (heat and irradiation), biological, and chemical treatments. However, these traditional aflatoxin decontamination technologies are not enough to remove the aflatoxin from the foods. Recently, some novel processing approached have been explored to achieve full degradation of the aflatoxin available with the foodstuffs, like microwave heating, gamma and electron beam irradiation, pulsed light, electrolyzed water, cold plasma, and so on. Decontamination mechanism, degradation efficiency, advantages, and limitations of these new technologies shall be discussed herein.",signatures:"Qian Yang",downloadPdfUrl:"/chapter/pdf-download/68690",previewPdfUrl:"/chapter/pdf-preview/68690",authors:[{id:"302867",title:"Ph.D.",name:"Qian",surname:"Yang",slug:"qian-yang",fullName:"Qian Yang"}],corrections:null},{id:"69100",title:"The Toxification and Detoxification Mechanisms of Aflatoxin B1 in Human: An Update",doi:"10.5772/intechopen.89221",slug:"the-toxification-and-detoxification-mechanisms-of-aflatoxin-b1-in-human-an-update",totalDownloads:1281,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Aflatoxin B1 (AFB1) is the most common carcinogen of aflatoxin, which contaminates many agricultural products in the daily diet of humans. More than 50% of patients with developing hepatocellular carcinoma (HCC) feature AFB1 exposure due to their shared consumption of contaminated food. One of the main mechanisms of AFB1-induced liver carcinogenesis is its biological activation and its interaction with DNA to produce AFB1-E-N7-dG adduct. This product may result in the formation of DNA damage and the mutations of tumor-associated genes such as TP53 and ras. In human, several pathways involving in AFB1 detoxification, including I- and II-type detoxification, DNA repair, have been reported. This study reviewed the detoxification mechanisms of AFB1 in human as well as AFB1 occurrence and toxification. Additionally, we also discussed prevention methods for AFB1 exposure.",signatures:"Qun-Ying Su",downloadPdfUrl:"/chapter/pdf-download/69100",previewPdfUrl:"/chapter/pdf-preview/69100",authors:[{id:"221960",title:"Dr.",name:"Qun-Ying",surname:"Su",slug:"qun-ying-su",fullName:"Qun-Ying Su"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"15",series:{id:"11",title:"Biochemistry",issn:"2632-0983",editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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\r\n\tSince the introduction of the first sub-picosecond lasers in the 1990s, the interest in femtosecond optics has grown rapidly. A femtosecond pulse is an electromagnetic pulse with a time duration of one femtosecond (10-15 seconds) or less. Understanding the behavior of the ultrashort light pulses makes it possible to develop ultra-fast lasers with a wide range of applications in such areas as micro-machining, chemical analysis, material processing, spectroscopy, and medical imaging.
\r\n\r\n\tThis book will be a compilation of works presenting recent advances and progress in femtosecond optics. It aims to focus on developing femtosecond laser systems, the study of the interaction of femtosecond light pulses with the matter, application of ultrafast nonlinear optics, and manipulation of ultrashort pulses to fill the need for a thorough and detailed account of femtosecond optics. We hope this book will be useful for engineers and managers, for professors and students, and for those who are interested in laser science and technologies. The rise of robotic technology continues in the new century, taking firm steps towards becoming a part of humanity day by day. Robots have become a part of both industrial production and human life, increasingly taking their place in factories, hospitals, schools, the military system, streets, and homes. As a result of this rapid involvement of robotic structures in modern life, scientists are accelerating both theoretical and applied studies on robotic manipulators. This book focuses on the latest developments in kinematics, dynamics, control, simulation tools, optimization, and structural design of serial, parallel, and hybrid robot manipulators. I would like to thank all the authors who will contribute to the book with their novel ideas in advance. During the last years, there was intense research on Ankylosing Spondylitis (AS) and related disorders, which were found to have a strong association with the HLA-B27 allele. Further studies showed that 92% of the population variance is due to genetic factors, and only a fraction of AS genetics can be explained by the influence of HLA-B27. Updated information on the genomic and auto-immune knowledge on AS is an important component of this book, calling attention to markers of disease activity, possible pathways, and the interaction with the gut microbiome, which are a step forward in the knowledge of the pathophysiology of AS, providing markers which are targets for the more recent biologic therapies.
\r\n\r\n\tAn update on clinical manifestations, their assessment, monitoring, and imagiology, including peripheral arthritis, enthesopathy, and extra-articular findings, and, the differential diagnosis with other diseases which evolves with axial and peripheral calcifications will be provided.
\r\n\tAn important component of this book must be dedicated to the more recent treatments namely with biologic therapies but focusing also on new small molecule inhibitors and experimental therapies.
An unprecedented number of full-time employees are working from home due to the global Coronavirus pandemic. Stay-at-home orders and encouragement to practice social distancing have forced individuals from all over the world to reconsider leaving their homes in order to reduce the spread of germs. What makes this point in time even more unique compared to similar previous situations is its intersection with the age of information and technology. With the emergence and development of technology, individuals are more accessible than they have ever been. In a time such as this one, these technological innovations can provide many individuals with the opportunity to fulfill their work obligations remotely.
Working remotely has increasingly become an option for individuals with the emergence of technologies that allow employees to communicate and be accessible at any time and any location. Before the COVID-19 pandemic began, more than 50% of workers across the world were spending at least two and a half days a week working outside of the office [1]. The United States federal Bureau of Labor Statistics reported 25% of paid workers worked from home periodically between the years 2017 and 2018 [2]. Notably, less than 70% of these individuals were paid for the work that they were doing at home and 12% of these individuals completed both unpaid and paid work from home [2]. Additionally, individuals are offered flexible schedules by employers, which can be amended to fit the time and space in which employees need to work in accordance with personal or familial needs.
Global survey trends indicate widespread support and use of technologies that allow for more flexibility in work locations. One survey of over 15,000 professionals around 80 countries conducted by a flexible workspace company known as International Workplace Group (IPG) revealed that companies have recognized how preferable workplace flexibility is for employees. The survey results show that while 84% of Australian companies use workspace flexibility as a tool in retaining employees, 80% of German companies have already offered workspace flexibility or intend to implement flexibility and 82% of US companies use workspace flexibility to improve work-life balance [1]. Relatedly, 90% of the over 1000 respondents who participated in the 2019 Staples Workplace Survey indicated that their employee morale would increase with more work-related flexibility [3]. Some individuals even seem to believe that flexible work arrangements is a major contributing factor in evaluating job opportunities and that flexible work environments could even increase diversity amongst employees [1].
Flexibility in the workplace also appears to be connected to productivity according to recent research. For instance, 87% of Argentinian business people considered their companies to be more productive on account of the flexibility in working and 45% reported that their businesses were over 40% more productive [1]. Globally, 85% of employees believe that they are more productive due to their workplace flexibility and 65% of respondents believe that organizations with workspace flexibility are more productive than other less flexible organizations [1]. During the pandemic, 97% of North American employees and 88% of global employees who worked in offices were working from home more than once a week and about 70% of employees reported being satisfied working in both places and that they believed they had the tools to perform efficiently working from home [4]. These perceptions about performance appear to be corroborated by managers, 70% of whom indicated in the first work-from-home survey done during COVID-19 that working remotely has had the same impact or has improved team performance on average [4].
While working remotely offers numerous benefits to employees and improves performance according to employers, constant accessibility and bringing work home using Information and Communication Technologies (ICTs) can have ramifications to work-life balance. Because organizational members learn rules and norms surrounding the use of ICTs through observation during assimilation [5], employers must be diligent about explicit and implicit messages from members of their organizations. When newcomers notice timestamps on emails from their supervisors that were sent past the close of business or when their coworkers comment about working on the weekends, they are absorbing messages from organizational members about where work-life balance falls on the company’s priority list. Therefore, new employees should realize their individual actions in turn shape the organizational behavior patterns [6] and learn how to best manage ICTs within the context of work and work-from-home.
In one recent pre-pandemic study, full-time employees reported working a 44-hour work week plus an additional five hours and 30 minutes working at home using ICTs [7]. The introduction of ubiquitous work-focused technology has shifted traditionally conceived work schedules [7], increased employer expectations of employee productivity and accessibility [8, 9, 10], and increased levels of individual distress [11, 12] and work-life conflict [7, 8]. Globally, the COVID-19 pandemic has catalyzed these effects, and strained professional and personal boundaries as millions of employees rapidly shifted work to home.
The obscured boundary between home life and work due to COVID-19 has broad impacts on the intersection of work productivity, especially among employees with parenting and caregiving responsibilities, and those with employment uncertainty [13]. In one study during COVID-19, working Italian mothers significantly shifted work hours to devote attention to work before and after parenting [14]. Indeed, the early research on employment during the pandemic suggests that a shift to remote work at home may exacerbate gender inequalities in paid [15] and unpaid work [14]. These impacts are in direct opposition with recent prescriptive research conducted on tools that are conducive to efficiently working from home during the Coronavirus, which concluded that the three most impactful drivers of performance success include self discipline, high quality remote collaboration, and work-from-home well-being (e.g., sleep, exercise, etc.; [4]).
These tensions that exist when lines between work and home are blurred necessitate a comprehensive review of existing literature with the aim of creating theoretically grounded and applicable guidelines for employees and employers alike. Therefore, this chapter offers a review of existing literature on the integration of organizational technology and work-life balance and a research-rooted acknowledgement of positive and negative aspects of organizational productivity technologies outside of working hours. From this review, conclusions with evidence-based best practices are presented on using work-focused technology at home.
Organizational technology use has changed workplace behaviors and altered the approaches that many take to working. In the digital age of “constant contactability” ([16], p. 109), individuals are expected by their employers to be available and productive outside of the originally conceived eight-hour workday [8]. These habits, though unhealthy, are not unpreventable.
The purpose of this paper is to address this issue by connecting the findings of relevant literature with theoretically grounded recommendations for managing work while prioritizing life. In doing so, it is important to start at the beginning of where patterns of behavior are observed within the organization by new members. Employees joining organizations are both modeling after existing norms while also using technology to seek information [17]. Thus, this review of literature will begin with a discussion of the assimilation phase of newcomers into technologically integrated organizations, focused on the mutually influential relationship of organizations and technology in Orlikowksi’s structurational model of technology [18, 19] and the constitutive communication of organizations model (CCO; [20, 21]). Following the theoretical foundations for organizational technology integration, we acknowledge both positive and negative aspects of ICTs and offer practical recommendations aimed toward individuals and organizational managers.
Organizational assimilation, defined here as the process of a newcomer learning about and acclimating to the organizational culture, values, and norms [22], is dynamic in nature and requires role negotiation as an individual becomes a member of an organization [23]. During this process, a newcomer simultaneously adjusts to a new group of individuals and plays a new role in an unfamiliar environment. Since uncertainty is such a fundamental experience in this process, individuals are predisposed to reduce or manage their uncertainty by engaging in information-seeking behaviors [5]. Organizational newcomers use official and unofficial mediated sources of organizational communication channels to learn about norms and to adapt their technology use to their organization’s [17].
One of the most common information-seeking behaviors that newcomers engage in during the assimilation phase is observing their surroundings and the people around them [5] and to model behaviors that they observe, both positive and negative [5, 24]. For instance, based on their influence and legitimate power, supervisors are likely to be perceived by their subordinates as role models [5, 25]. Based on this logic, seeing other organizational members prioritize their work-related roles and responsibilities during and after work hours utilizing ICTs could influence a newcomer to do the same. One important factor to consider for newcomers observing the patterns and habits of their colleagues regarding use of ICTs while outside of work is how technology-focused the organization is.
As previously mentioned, the process of assimilating into an organization is centered around a new organizational member becoming entrenched in the organization’s culture. One facet of an organization’s culture contains the group’s orientation surrounding technology, and in response, ICTs. Leonardi and Jackson [26] developed the notion of
In technologically grounded organizations, technology use by newcomers and existing organizational members is embedded into daily communication practice. For newcomers, ICTs are almost as important as face-to-face communication and function as conduits to organizational socialization [27]. As previously stated, the process of organizational assimilation is one that involves negotiations both on the side of the newcomer and on the side of the organization and its existing members [28]. The notion that individuals are developing their organizational roles while existing within and constituting their organizations during assimilation [27, 28, 29] is meaningful in the context of the organizational integration and impact of ICT on individuals’ work-life balance.
New employees and organizations reciprocally influence one another during the assimilation process, as newcomers define their roles and the organizational culture and structure continuously adjusts with its members [27, 28, 29]. The aforementioned definition of assimilation as a mutually influential process between organizations and organizational members lends itself to the notion that an organization is both formed and informed by its members.
Giddens’ [6] original theory of organizational structuration posited that individuals’ everyday actions are organized by structures which serve as the fabric of society. These structures, embodied by rules and norms, are produced and reproduced by those who act within them, as actors’ inclinations to behave in accordance with norms often result in actions taken in accordance with rules [6]. Patterns of interactions within organizations create a duality of structure in which employees who abide by organizational norms communicate meaning and power through their interactions with other organizational members.
Regarding the availability and use of ICTs for remote work, structures in the form of cultural norms and employer expectations for employees to work outside of work hours [8] are created when work permeates the spatiotemporal boundary of home [30]. The employee who consistently uses ICTs to communicate with others outside of the bounds of typical work hours reinforces these structures. That employee’s role or status within the organization may be influential in the assimilation process for newcomers who look for meaning and organizational norm structures modeled from existing organizational members. This structuration lens is particularly helpful when suggesting practical recommendations, as individuals can make choices while using technology to manage work-life matters that both reinforce and challenge existing organizational structures.
Orlikowski’s theorizing [18, 19] integrated technology into structuration theory, both as a means for humans to communicate and as a product of such human interaction and relationships. The structurational model of technology recognizes that technology can play a facilitating and constraining role in organizational communication, but that institutions shape how people use technology. “When users conform to the technology’s embedded rules and resources, they unwittingly sustain the institutional structures in which the technology is deployed” ([18], pp. 411-412). Individuals within organizations select mediums for communication appropriate for the goals of the organization. In the earliest forms of electronic organizational communication, scholars assert that mediated communication was primarily used for formal, both internal and external communication (e.g., electronic letters and memos; [31]), but as structuration theory suggests, the functions and genres of mediated communication quickly evolved to include a variety of formal and informal methods of communication in organizations.
As organizations and people shape one other, people and technology also shape one other and, in turn, shape the rules and norms of the organizations that they constitute. Organizational discourse is the avenue through which these technological norms are passed. As stated by Orlikowski [19], “enacted structures of technology use, which I term technologies-in-practice, are the set of rules and resources that are (re)constituted in people’s recurrent engagement with the technologies at hand” (p. 407). Technologies-in-practice, then, are constituted and reconstituted also through the shared organizational discourse of ICT use. Under the perspective of the communicative constitution of organizations [20, 21], a theory that stemmed from structuration theory, communication functions not as the result of organizing with others, but as the precursor.
As the mechanism through which organizational norms, rules, and values are developed and solidified [32], communication plays the most significant role in organizations. Based on this premise, the way for individuals to defy the norm of bringing work home that has thus far been discursively reproduced would be to communicate about it with their coworkers. In doing so, other organizational members have the opportunities to also communicate, evaluate this norm, and, perhaps, commit as a community to a more balanced work-life schedule.
Organizational technology permeating the spatiotemporal boundary of home and life outside of work is growing into a more significant issue with the emergence of more ubiquitous work-centered technological modalities. In order to recognize how newcomers develop or reinforce these imbalanced habits, a review of existing research regarding the role of ICTs in organizational assimilation and for newcomers acclimating to organizational culture was presented. In the situation of individuals who bring their work home, particularly during the global Coronavirus pandemic, organizational technology use was introduced as a ubiquitous opportunity to work from any place at any time but in practice is employed to work from all places all the time. As individuals experience this phenomenon more, either by executing it themselves or by witnessing it by a coworker or supervisor, the norm is discursively re-produced and the structure is bolstered. As working from home emerges into an organizational cultural norm, investigating the use of technology and its challenging yet beneficial role in work-life balance is imperative. In the following section, both sides of the role that technology plays in work-life balance is discussed.
There are many considerations of the use of ICTs at home that are positive in nature. Perhaps most salient is the notion that telework reportedly offers greater flexibility, which many view as a remedy to having a healthier work-life balance [33, 34] and which is associated with greater job satisfaction [35]. Along with this, people who believe that communication technologies are convenient for completing work at home report less conflict between work and personal life due to technology use [7]. Individuals may also use ICTs to be more productive [8]. Those who use ICTs as an extension of work from home perceive that they are more productive [36], albeit distressed, which we discuss in the following section.
From the organization’s perspective, ICTs are positive in that the communication channels allow newcomers to seek information and socialize with other organizational members [27]. ICTs have also been shown to increase frequency and duration of organizational communication while promoting cohesion, improving group performance, and providing a forum for information exchange [27]. As noted previously in this chapter, in light of the Coronavirus, data supports that managers believe that working from home has made their teams more productive, in some cases significantly more productive [1]. In spite of these positive aspects of organizational technology use for employers and employees, there are noteworthy drawbacks.
Although increased productivity is one of the primary determinants for organizational adoption of technology modalities [22], organizations may not truly realize these enhanced results. Pre-pandemic, most employees who brought work home reported having done so to catch up on unfinished work, yet productivity measures did not indicate that workers with extra at-home work hours experienced increased productivity for the additional hours worked [37]. Distractions, faster-paced interactions, and multi-tasking may be explanations for why the hours worked at home have historically seemed less productive [38]. Thus, the
Beyond the heightened expectations of productivity, there are negative personal and professional consequences when the boundaries between work and home are blurred through ICTs. The spillover effect of work into home life has a negative effect on attitudes toward work [39] and family satisfaction, especially among women [40]. Employees can also experience “technostress” due to the use of ICTs [11, 36]. Additionally, having greater expectations for work hours and productivity contribute to work-life conflict [8], job dissatisfaction, and employee burnout [7]. For employers concerned with employee retention, these longer-term consequences of expecting employees to complete work at home are especially costly.
These consequences of work-life imbalance rooted in the overuse of organizational ICTs may carry significant implications in the aftermath of the work from home incited by Coronavirus. During COVID-19, research has shown that organizational technology reliance can contribute to increases in cyberbullying [41], intensified work environments [42], and more surveillance measures [43]. The COVID-19 pandemic may further reinforce perceptions of work and productivity differences between parents and childless employees that were already present [44], as many parents negotiate the role conflict of acting as homeschool teachers and working as full-time remote employees. However, while research about these ramifications are salient and grounded in application to the lives of workers, employee retention, and job satisfaction, individuals may justify supposed temporary imbalances or negative consequences because of the uncertainty of employment.
Research indicates that there is evidence for both positive and negative aspects of employees using ICTs to perform work from home. As the boundaries that separate work from home are blurred, the balance between the “bidirectional permeability” could have both positive and negative aspects, as “employees will likely expect to do family-at-work if they are expected to do work-at-home” ([19], p. 120). While employers and employees mutually benefit from more flexible scheduling and more easily accessible technologies for work tasks and communication after traditional work hours, employees may find that working from home expands the number of hours worked by relocating them to home rather than in an office in practice, as a breadth of research suggests [10]. The following section offers research-based, practical recommendations for a wide variety of individuals, including employees and employers, which are especially relevant due to the current climate of necessitated work-from-home strategies and the imposition of organizational technology on personal boundaries.
For Employers:
Communicate cultural values and expectations--verbally and nonverbally. Technology-centric values are inherently and fundamentally rooted in the cultures of organizations that are more technologically grounded [26]. Organizational expectations, particularly ones centering around technology use and work-life balance, should be communicated upfront and repeated often. Existing research [16] has recommended that organizations ensure work-life balance or principles of reciprocity for newcomers through the introduction of an “acceptable use” policy. This method explicitly outlines guidelines on appropriate and inappropriate uses of organizational technology and is a useful option that employees can refer to when necessary. Another option here is to engage in the “discourse of reciprocity” ([16], p. 118), where organizations offer personal flexibility in exchange for employees being flexible with their work schedules. Regardless of what approach is employed to convey cultural values and expectations, direct communication is most important.
Provide training on ICTs and guidelines for their use to newcomers during onboarding. When an individual joins an organization, they are the most likely to seek out information on cultural rules and norms [5]. During these times, managers should provide training on both the available ICT itself while also covering the established guidelines on its use. This ensures that newcomers who may not be previously familiar with the technology are provided with instructions to utilize them. But, in addition, training should include expectations on its use, such as response time, availability timeframes, and security guidelines. Training of this kind should help organizations leverage the socialization and collaboration functions of ICTs [27] while also minimizing the negative aspects that have been outlined in earlier research [8, 11].
Enact a top-down approach in displaying positive technology behaviors. Structurationally speaking, agents and actions are necessary for structures to be enacted [6]. The more power and influence that the agents who are enacting organizational structures and shifting cultural norms have, the more effective and influential they are at modeling change. In addition, supervisors act as role models for newcomers after whom newcomers adapt behavior [5, 24, 25]. If supervisors and employers demonstrate behaviors that promote better work-life balance, those values will be adopted by newcomers, and employees who feel organizational support to pursue commitments unrelated to work will feel more committed to their organizations [39]. Therefore, there are benefits that both organizations and their members can realize when work-life balance is practiced.
For employees:
Create and reinforce the boundary between work and life. Existing research has suggested that greater connectivity leads to greater boundary permeability [8, 30] and that role conflict is directly influenced by boundary permeability [45]. However, that does not have to be the case. Disengaging personal devices from professional accounts when possible outside of work hours or regulating use of organizational apps outside of work hours or during time away from work are helpful steps in creating and reinforcing the separation that can exist between the work and home spheres. Remember that structures cannot take form without agents taking action [6], which requires coordinating and organizing.
Monitor working from home habits (and counterbalance, if necessary). Existing researchers support the notion that individuals who bring work home with them also bring home to work with them and recommend that employees develop structures to counteract the presence of work at home [16]. Relatedly, other research recommends substituting (not adding!) hours worked at home for hours worked on site [10].
Own the balance. Behaviors lead to the development of habits, which lead to the creation of norms and expectations. In order to achieve balance in the amount of ICT work from home, start by discussing realistic expectations with colleagues and family members about fluctuations in work projects or family commitments. There may be times when blurring the lines of work and home are unavoidable but having clear expectations about positive and negative technology behaviors may help eradicate bad habits. Norms of organizational technology use are the mechanism through which individuals permeate the boundary of home [16], so taking control of the habit and resisting the norms are the most important pieces to mitigating work-life imbalance.
The use of technology to communicate in organizations has become crucial in the midst of the global Coronavirus pandemic as the only feasible way for people to engage with one another without compromising the social distancing and stay-at-home orders. As more individuals are tasked with navigating the balance working from home, both organizations and employees are looking for practical recommendations based in previous research. Although there is much research to be done within the realm of organizational communication in this global pandemic context, we can still find ways that existing organizational and business communication research on organizational technology integration and work-life balance work to inform this once-in-a-century scenario.
It is essential that the risks and rewards of work-centered technological advances are considered and that the implications of merging them with other components of life are addressed in reviewing research and developing conclusions about the role of ICTs in the work-from-home transition during Coronavirus. For this reason, the purpose of this chapter has been to review existing literature on the integration of ICTs in organizations and during the process of working from home as a means to develop some theoretically grounded recommendations for both individuals to better balance their work and home lives and for employers to intentionally create a culture in which this is achievable. Although the current climate for organizations is one of turbulence and uncertainty, research reviewed here supports both employees and employers prioritizing individual well-being and employing healthy work habits throughout the integration of and reliance on information communication technologies.
Dental caries is considered one of the most common chronic diseases affecting the global population [1]. An important aspect associated to dental caries is the potential serious consequences upon the general health of the individuals [2]. Previous studies stated the fact that oral bacteria can spread and determine various systemic health implications, being responsible for secondary infections of different organs [2]. Multiple research studies discuss the involvement of persistent oral bacteria, due to an inadequate oral hygiene, specific dental procedures or periodontitis in the initiation of endocarditis [3]. The oral environment can be influenced, as well, by the general health status and treatments with a direct impact upon the oral microbiota balance, the salivary flow, and pH. A high interest has been shown in identifying the composition, properties, and implications of the oral microbiome and its consequences upon the salivary pH, oral pathologies, and systemic diseases. The prevalence of dental caries is still characterized by high values despite the prevention measures applied worldwide. Its incidence continues to increase dramatically once the risk habits prevalence in the developing countries changes. However, it has been reported that a small percentage of young adults can still be characterized as being caries-free. Unfortunately, the efforts to identify risk populations by using a screening method had no significant result [4].
The etiology and the pathogenesis of dental caries are being considered complex multifactorial processes [5]. An important role is assigned to saliva, its rate and composition being most important in the initiation and progression of the cariogenic process. Being the body fluid, which is in permanent contact with the teeth and soft oral tissues, it is held responsible for their integrity and for the permanent remineralization of the dental structures, as well. The quantity of the salivary flow, the characteristics of saliva, and its buffer capacity are involved in maintaining a proper balance of the oral environment. Any alterations of these characteristics can influence the demineralization process and are consequently responsible for the development of caries. The salivary components may have a substantial implication in the reduction of the risk factors involved in dental caries incidence [5].
The factors associated with occurrence of dental caries are the host (the presence of teeth and saliva), the oral microbiome (the bacterial population), and the dietary habits (based on carbohydrates). Basically, all these factors contribute and conduct to the development of the disease. Caries is characterized by a progressive evolution, being reversible in early stages, and suggesting that the abovementioned factors must have a cumulative action for a certain period of time. Dental caries is the result of the interaction between the oral microbiome accumulated on teeth’s surface (dental plaque) with the fermentable sugars form the diet, with consequences upon the buffering capacity of the saliva, lowering its pH, and weakening the normal remineralization process [6].
The demineralization and remineralization cycles of the enamel, under the action of the cariogenic bacteria from the dental plaque, are quite frequent mechanisms that occur in the oral cavity, episodically. Enamel has a unique structure, without any organic components that could contribute to its repair or defense against a potential cariogenic attempt. In the early stages of the demineralization process, the action of saliva combined with the mechanical removal of the dental plaque and application of topic fluorides may stop and reverse the process.
An accurate evaluation of the dental caries risk should take in consideration the implication of saliva in the process. The use of a salivary test in the assessment of the individual risk may have an impact upon the prevention strategies, screening, and early diagnosis of dental caries, making a difference in the incidence statistics of dental caries [6].
The oral cavity and the teeth are permanently exposed to the action of saliva [7]. The oral fluid is the result of the secretion of multiple salivary glands: the parotid, submandibular, sublingual, and the minor salivary glands localized in multiple areas of the oral mucosa. Free epithelial cells, bacteria, crevicular fluid, inflammatory cells, and food particles are among the components of saliva. The implications of saliva and its functions contribute to the maintenance of the oral health [8]. One of its main roles is hydrating and lubrication of the surrounding tissues. The submandibular, parotid, sublingual, and minor salivary glands contribute with 60, 25, 8, and 7%, respectively, to the whole saliva amount, when in unstimulated state. In case of salivary flow stimulation, their secretion increases with at least 10% [9]. The salivary flow varies from 0.3 ml/min up to 1.5–2.0 ml/min, depending of the state: stimulation period or rest. There are circadian variations involved, as well, during the day 0.5 liter of saliva is secreted, compared with night when the flow rate is highly decreased [9].
Saliva and its actions are dependent on its quantity and quality. Being in permanent contact with the oral tissues, it has influence on actions such as speaking, swallowing, and eating, protecting the mucosa and the surface of the teeth. The protective role of the saliva is supported by a proper viscosity, flow rate, balanced composition, pH, and buffer function [10]. Any alterations of these characteristics may result in developing oral pathologies such as dental caries (Figure 1).
Roles and functions of the saliva.
To date, research has focused on identifying the relationship between the characteristics of saliva and the incidence of dental caries. Several studies reported that there was a connection between the viscosity of saliva and the development of dental caries [8]. The high cariogenic activity due to the alteration of the salivary characteristics could be explained by a reduced flow rate, a decreased clearance and buffer capacity, and a high glucose concentration. It has been shown that the salivary flow rate was significantly lower in individuals with active caries compared with caries-free ones [11]. The buffer capacity and the pH values have direct consequences upon the salivary flow rate and viscosity [10].
The composition and flow rate of saliva vary in relation with different factors, such as stimulation or rest periods [10]. In the rest periods, the salivary flow rate represents ¼ out of the total stimulated flow potential. During the stimulated flow, the composition and pH of the saliva change, a more serious saliva consistency facilitates the digestive process and increases the clearance function [12]. The immune surveillance role of the saliva is due to immunoglobulins, secreted by the plasma cells of the lymphoid tissue belonging to the major salivary glands. The epithelial cells localized in the salivary acini produce proteins with a protective role against bacteria and viruses.
Because of its complex composition, saliva has multiple actions in the oral environment. In vitro studies, focused on the interaction between the cariogenic microorganisms in the dental plaque and the salivary proteins, suggest that interleukins, lysozyme, mucins, and lactotransferrin contribute to the cell aggregation, inhibition action, and adherence of the bacteria, suggesting that the salivary proteins may have a diagnostic potential, allowing the development of personalized treatments [13, 14].
Dental caries is represented by a localized demineralization with progressive loss of the tooth components. The healthy oral environment is in symbiosis with the oral microbiome, in case of a neutral pH value. The bacteria from the oral biofilm are responsible for metabolizing the carbohydrates and producing permanent organic acid products, which are able to lower the pH, with effects upon the tooth composition and biofilm [15]. A long-time persistence of a lower pH value influences the bacterial population of the biofilm, producing a shift in the oral microbiome and promoting the acidogenic bacteria [16]. These changes will eventually have repercussions upon the oral environment by the acidification process. A low pH value will result in the extraction of phosphate and calcium from the tooth structures, in order to attempt to equilibrate the acid environment, determining their demineralization. These types of actions take place several times per day and are being influenced by numerous other mechanisms and factors such as oral hygiene, diet, oral microbiome diversity, genetics, dental anatomy, biofilm, salivary flow, buffer capacity, and composition (Figure 2).
The contribution of the pathological and protective factors.
Saliva has an important role in maintaining a healthy oral environment and proper digestion, and its alterations can be the cause of multiple diseases, including dental caries.
The buffer capacity of saliva plays an important role in mediating the relationship between the tooth surface and the biofilm, normally exhibiting a protective role against the development of dental caries [17]. This specific characteristic of saliva is represented by the concentration of the bicarbonate ion. The buffer capacity may be quantified and assessed, in case of active-caries individuals, by a titration method, from salivary samples. The implications of the buffer action rely on reducing the acid formation in the dental biofilm. In case of a pathogenic action, the neutralization of an acidic pH environment, and shifting it into a neutral one, has proven to be quite difficult [18].
The composition of saliva has an important contribution in maintaining and increasing the value of the pH biofilm. Among its main constituents, which efficiently determine the pH to increase are sialin (that contains arginine and lysine) and urea. Further hydrolyzation of each of these molecules results in releasing ammonia, with a direct contribution in increasing the pH.
In order to maintain the oral health and the integrity of the tooth surface, the pH value should be kept around the value of 6.7. The ion concentration and activity are responsible for demineralization and remineralization processes through the solubility of hydroxyapatite [19]. A decreased and critical pH value is considered at a value of/under 5.5.
The pH value is directly related to the concentration of the phosphate and calcium ions. Salivary flow and its variations have consequences upon the pH value, by exhibiting different concentrations of calcium and phosphate. It has been reported that the pH value can be increased by one unit only through stimulating the salivary flow rate. Differences between the unstimulated and stimulated saliva have been identified, as the unstimulated saliva has a lower pH value compared with the stimulated one, due to its higher concentration in phosphate [20]. The critical pH value presents individual variations, as the salivary concentrations of calcium and phosphate vary from one person to another. It should also be mentioned that the critical pH fluctuations are dependent on multiple factors [21].
Saliva has three buffering systems, which are represented by phosphate, bicarbonate, and protein systems. The major system being considered is the acid/bicarbonate one, present in the stimulated salivary secretion. Its action starts with food intake, by decreasing the pH value and increasing the concentration of bicarbonate. The phosphate buffer system and its effectiveness are dependent on the salivary concentration of the phosphate ion and have been reported to have a moderate action in case of unstimulated saliva [22]. The salivary proteins represent another buffer system, through their action of absorbing and releasing protons. Their action may result in increasing the saliva viscosity when the pH value is low, protecting the tooth structure from acid production, by exhibiting a physical barrier [20].
The pH value during rest periods has been reported to have the ability to predict the caries status of the patient and outline the buffering capacity of the saliva. Patients with resting salivary pH value of approximately 7.0 have been reported to have a lower caries activity compared with those with pH values of 5.5, who exhibited a high caries incidence. In individuals with pH values between 5.5 and 7.0, the caries incidence was less severe. A lower value of a resting pH suggests a lower pH value when exposed to carbohydrates, with a prolonged maintenance of this lower value, until returning to the resting pH [8]. These facts suggest that the changes during a lower pH value result in exposing the tooth structure to an acidic environment, for a longer period of time, without the possibility of neutralizing it.
The presence of dental caries influences the carbohydrate clearance, resulting in a prolonged contact with the dental plaque and a continuous decrease of the salivary pH value [11]. The presence of dental caries and alteration of the oral environment promote the production of acid, supplementary bacterial adhesion, and low salivary clearance activity. A previous published study concluded that the salivary flow rate, the buffer capacity, and pH value were decreased in active-caries children compared with the caries-free group [23].
The implication of the salivary pH in the multiplication and survival of oral microorganisms is an important aspect in the etiology of dental caries. In case of a low pH, the acidophilic microorganisms will multiply, considerably increasing the caries risk [24]. A high incidence of dental caries, dysphagia, and other oral pathologies has been linked to a decreased salivary flow, clearance, and buffer capacity. Special attention should be paid to the patients with decreased saliva secretion, with repercussions upon the oral mucosa, upon the viscosity and buffer capacity, favoring the development of opportunistic infections and increasing the risk of dental caries [25].
The oral cavity and the salivary composition and characteristics may be defined as the mirror of the general health status. Saliva represents the first body fluid, which comes in contact with multiple pathogens, being responsible for their neutralization, and for the homeostasis of the oral environment. Recent studies have revealed the importance of assessing the levels of salivary antioxidants and reactive oxygen species, which have a high implication in the incidence of dental caries.
A clinical study conducted on children diagnosed with iron deficiency anemia revealed its impact upon the salivary pH value and buffer capacity. By collecting unstimulated saliva and serum samples from the patients, before and after treatment, the salivary buffer capacity and pH values have been quantified. The serum ferritin levels were measured, in order to outline their role as dental caries and iron deficiency anemia biomarkers. The results showed that 3 months after treatment, the buffering capacity and the salivary pH have increased, suggesting a direct implication of the iron deficiency anemia in altering the salivary functions with secondary implications in the cariogenic activity [26].
The salivary dysfunction related to primary Sjögren’s syndrome may be the cause of multiple oral manifestations. The results of several studies discuss the fact that patients diagnosed with primary Sjögren’s syndrome have a high incidence of dental caries, exhibiting mostly cervical carious lesions, despite an acceptable oral hygiene status [27]. Several salivary factors that have been encountered in primary Sjögren’s syndrome patients have been linked to the high incidence of caries. The main problem related to this pathology is the influence upon the saliva formation, patients experiencing a decreased salivary flow rate, and an alteration in the salivary composition, due to the presence of focal lymphocytic infiltrate in the salivary glands. Pedersen et al. [28] conducted a study that aimed to identify and evaluate the salivary flow and composition and the incidence of dental caries in patients diagnosed with primary Sjögren’s syndrome. The results showed that the included patients exhibited a decreased salivary flow rate, and the pH and bicarbonate concentration of the parotid gland’s saliva were significantly decreased compared with the control group. Although patients had accurate oral hygiene habits and reported using dental floss and fluoride toothpaste, the caries incidence and gingival index were high. These patients also had a higher number of acidophilic, cariogenic bacteria in the dental plaque compared with the control group, and a relationship between the decreased salivary flow and the high incidence of Lactobacillus has been observed. Among all the oral manifestations, oral dryness and a reduced salivary flow rate were the main accuses of the patients [29].
A decreased salivary flow has been reported in diabetic patients, the incidence of type I diabetes among young patients may have repercussions on the oral health, especially teeth integrity. The association between dental caries and diabetes has been one of the most researched subjects. As type I diabetes is associated with the critical years of dental eruption, the attention in identifying its potential implication on the dental status has been considered a necessity. Studies have reported a high incidence of dental caries, dry mouth (xerostomia), and gingival inflammation in young patients diagnosed with type I diabetes compared with healthy ones. One of the main causes that could explain this outcome, besides a poor oral hygiene, could be the decreased salivary flow rate and alteration of the composition of saliva. Elevated glucose concentration has been identified in the saliva, sustaining an acidogenic oral environment and the colonization of bacteria. All these changes in the flow rate, salivary composition, and an inadequate oral hygiene influence the incidence of dental caries [29]. Studies including patients with type I diabetes showed that the salivary flow and pH value were significantly reduced compared with the control group, the prevalence and severity of dental caries in type I diabetes being a high one [29].
High incidence of dental caries, mucositis, and inflammation has been identified in acute lymphoblastic leukemia. The main changes are related to the compromised immune system, influencing the oral environment as well. Hegde et al. [30] conducted a study focusing on the implication of acute lymphoblastic leukemia on the oral health and dental status. They aimed to identify the direct action of the disease, as well as the influence of chemotherapy on the salivary flow and dental caries incidence. The study included patients divided into four groups (without chemotherapy, at the beginning of chemotherapy treatment, after 4 weeks of chemotherapy, and a control group). The results showed that all three groups with acute lymphoblastic leukemia experienced a low salivary flow rate and pH values compared with the control group. The antioxidant salivary levels were increased in the first two groups and decreased in the third group of leukemia patients. Poor oral hygiene and gingival inflammation were reported in all leukemia patients, and the incidence of dental caries was a high one. The influence of chemotherapy on the salivary flow through the hypoplasia of the salivary glands is a common consequence of this treatment. Another cause for the poor dental health status, besides the abovementioned salivary changes, could be the discomfort caused by the inflammation of the oral mucosa that reduces the possibility of maintaining a proper oral hygiene [30].
The role of saliva in the diagnosis of multiple diseases through its composition and actions is currently accepted. The salivary secretion is controlled by a reflex arc influenced by multiple actions. For the salivary flow and composition, the parasympathetic and sympathetic systems are responsible. Multiple studies were conducted in identifying the stress-related consequence upon the saliva [31]. Results show an increase in the acidity levels of saliva in case of anxiety and a decrease of the salivary flow and pH value with consequences upon the tooth structure [31]. Said et al. [32] conducted a study, which aimed to identify the relationship between the anxiety levels and the changes encountered in the saliva. The results outline the existence of a low pH value in the study group, compared with the control group, revealing a higher prevalence among males with a low anxiety level. These alterations could be a further explanation for the prevalence of dental caries among these patients.
Systemic health plays an important role in maintaining an adequate oral environment. Changes specific to various diseases can directly influence the salivary production, composition, and functions, with influence on the prevalence of dental caries. Over the past years, research has opened a new path that includes the use of saliva for screening, diagnosis, and monitoring of multiple pathologies.
Among the numerous factors linked to the incidence of dental caries, the oral microorganisms and saliva are of most importance. The role of saliva cannot be underestimated, its composition revealing important information regarding the involvement of systemic and oral conditions. Research has focused on outlining the importance of the salivary functions and characteristics in the development of dental caries. Connections between the pH values and the prevalence of caries have been pointed out, the influence of local and general factors, as well as the impact of pH variations upon the tooth structure. An acidogenic oral environment results in an imbalanced demineralization and remineralization process, with a multiplying community of acidophilic bacteria. The key in the management of dental caries is addressing the causative factors, both general and local, and obtaining a neutral oral pH.
The authors declare no conflict of interest.
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Experimentation is an application of treatments applied to experimental units and is then part of a scientific method based on the measurement of one or more responses. It is necessary to observe the process and the operation of the system well. For this reason, in order to obtain a final result, an experimenter must plan and design experiments and analyzes the results. One of the most commonly used experimental designs for optimization is the response surface methodology (RSM). Because it allows evaluating the effects of multiple factors and their interactions on one or more response variables it is a useful method. In this section, recent studies have been compiled which aim to extraction of plant material in high yield and quality and determine optimum conditions for this extraction process.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Alev Yüksel Aydar",authors:[{id:"218870",title:"Dr.",name:"Alev Yüksel",middleName:null,surname:"Aydar",slug:"alev-yuksel-aydar",fullName:"Alev Yüksel Aydar"}]},{id:"56460",doi:"10.5772/intechopen.69501",title:"Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes",slug:"application-of-taguchi-based-design-of-experiments-for-industrial-chemical-processes",totalDownloads:3219,totalCrossrefCites:27,totalDimensionsCites:53,abstract:"Design of experiment is the method, which is used at a very large scale to study the experimentations of industrial processes. 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Taguchi method is a broadly accepted method of DOE, which has proven in producing high-quality products at subsequently low cost.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Rahul Davis and Pretesh John",authors:[{id:"199438",title:"Mr.",name:"Rahul",middleName:null,surname:"Davis",slug:"rahul-davis",fullName:"Rahul Davis"}]},{id:"15157",doi:"10.5772/15959",title:"Fourier Transform Mass Spectrometry for the Molecular Level Characterization of Natural Organic Matter: Instrument Capabilities, Applications, and Limitations",slug:"fourier-transform-mass-spectrometry-for-the-molecular-level-characterization-of-natural-organic-matt",totalDownloads:4344,totalCrossrefCites:6,totalDimensionsCites:34,abstract:null,book:{id:"122",slug:"fourier-transforms-approach-to-scientific-principles",title:"Fourier Transforms",fullTitle:"Fourier Transforms - Approach to Scientific Principles"},signatures:"Rachel L. 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There are several ways to apply robust optimization and the choice of form is typical of the problem that is being solved. 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In this section, recent studies have been compiled which aim to extraction of plant material in high yield and quality and determine optimum conditions for this extraction process.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Alev Yüksel Aydar",authors:[{id:"218870",title:"Dr.",name:"Alev Yüksel",middleName:null,surname:"Aydar",slug:"alev-yuksel-aydar",fullName:"Alev Yüksel Aydar"}]},{id:"74096",title:"Time Frequency Analysis of Wavelet and Fourier Transform",slug:"time-frequency-analysis-of-wavelet-and-fourier-transform",totalDownloads:1283,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"Signal processing has long been dominated by the Fourier transform. 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In all cases, cyclical ups and downs depend not only on internal system cyclical processes and their factors in countries but also on the consequences of intercountry interaction. The ability to measure and predict business cycles, taking into account their mutual influence, is a prerequisite for the development of an adequate business policy of countries and their associations.",book:{id:"6703",slug:"statistics-growing-data-sets-and-growing-demand-for-statistics",title:"Statistics",fullTitle:"Statistics - Growing Data Sets and Growing Demand for Statistics"},signatures:"Elena Zarova",authors:null},{id:"54366",title:"Solution of Differential Equations with Applications to Engineering Problems",slug:"solution-of-differential-equations-with-applications-to-engineering-problems",totalDownloads:6866,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Over the last hundred years, many techniques have been developed for the solution of ordinary differential equations and partial differential equations. While quite a major portion of the techniques is only useful for academic purposes, there are some which are important in the solution of real problems arising from science and engineering. In this chapter, only very limited techniques for solving ordinary differential and partial differential equations are discussed, as it is impossible to cover all the available techniques even in a book form. The readers are then suggested to pursue further studies on this issue if necessary. After that, the readers are introduced to two major numerical methods commonly used by the engineers for the solution of real engineering problems.",book:{id:"5513",slug:"dynamical-systems-analytical-and-computational-techniques",title:"Dynamical Systems",fullTitle:"Dynamical Systems - Analytical and Computational Techniques"},signatures:"Cheng Yung Ming",authors:[{id:"191017",title:"Dr.",name:"Cheng",middleName:null,surname:"Y.M.",slug:"cheng-y.m.",fullName:"Cheng Y.M."}]},{id:"56538",title:"Stochastic Resonance and Related Topics",slug:"stochastic-resonance-and-related-topics",totalDownloads:1718,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The stochastic resonance (SR) is the phenomenon which can emerge in nonlinear dynamic systems. In general, it is related with a bistable nonlinear system of Duffing type under additive excitation combining deterministic periodic force and Gaussian white noise. It manifests as a stable quasiperiodic interwell hopping between both stable states with a small random perturbation. Classical definition and basic features of SR are regarded. The most important methods of investigation outlined are: analytical, semi-analytical, and numerical procedures of governing physical systems or relevant Fokker-Planck equation. Stochastic simulation is mentioned and experimental way of results verification is recommended. Some areas in Engineering Dynamics related with SR are presented together with a particular demonstration observed in the aeroelastic stability. Interaction of stationary and quasiperiodic parts of the response is discussed. Some nonconventional definitions are outlined concerning alternative operators and driving processes are highlighted. The chapter shows a large potential of specific basic, applied and industrial research in SR. This strategy enables to formulate new ideas for both development of nonconventional measures for vibration damping and employment of SR in branches, where it represents an operating mode of the system itself. Weaknesses and empty areas where the research effort of SR should be oriented are indicated.",book:{id:"6128",slug:"resonance",title:"Resonance",fullTitle:"Resonance"},signatures:"Jiří Náprstek and Cyril Fischer",authors:[{id:"207472",title:"Dr.",name:"Jiri",middleName:null,surname:"Naprstek",slug:"jiri-naprstek",fullName:"Jiri Naprstek"},{id:"213311",title:"Dr.",name:"Cyril",middleName:null,surname:"Fischer",slug:"cyril-fischer",fullName:"Cyril Fischer"}]}],onlineFirstChaptersFilter:{topicId:"15",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83034",title:"Optimal N-of-1 Clinical Trials for Individualized Patient Care and Aggregated N-of-1 Designs",slug:"optimal-n-of-1-clinical-trials-for-individualized-patient-care-and-aggregated-n-of-1-designs",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.106352",abstract:"Precision medicine typically refers to the use of genomic signatures of patients to assign more effective therapies to treat patients, or, for improved diagnosis of the early onset of a disease so that interventions can be delivered to prevent or delay the disease progression. 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We construct examples of universally optimal N-of-1 designs for comparing two treatments under various correlation structure assumptions and discuss how N-of-1 trials may be combined to form optimal aggregated N-of-1 trials for assessing average treatment effects for two or more treatments.",book:{id:"10678",title:"Biostatistics",coverURL:"https://cdn.intechopen.com/books/images_new/10678.jpg"},signatures:"Yin Li, Weng Kee Wong and Keumhee Chough Carriere"},{id:"83029",title:"Quasi Conformally Flat Quasi Einstein-Weyl Manifolds",slug:"quasi-conformally-flat-quasi-einstein-weyl-manifolds",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105683",abstract:"The aim of this work is to study on quasi conformally flat quasi Einstein-Weyl manifolds. In this book chapter, firstly, an interesting relationship between complementary vector field and generator of the quasi Einstein-Weyl manifold is obtained and supported by an example. Then, it is investigated that quasi conformally flat quasi Einstein-Weyl manifolds are of quasi constant curvature, recurrent and semi-symmetric under which conditions after obtaining the expression of the curvature tensor of the quasi conformally flat quasi Einstein-Weyl manifold. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. Gonzalez-Sanchez",slug:"juan-a.-gonzalez-sanchez",fullName:"Juan A. Gonzalez-Sanchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico System",country:{name:"United States of America"}}},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}}]}},subseries:{item:{id:"3",type:"subseries",title:"Bacterial Infectious Diseases",keywords:"Antibiotics, Biofilm, Antibiotic Resistance, Host-microbiota Relationship, Treatment, Diagnostic Tools",scope:"