The number of diagnosis of the children made in the maternity hospital and by local doctors.
\r\n\tThis book will intend to look at different migrant patterns, voluntary and involuntary migration, over the last three centuries. What influenced people to leave their home countries, family, and friends and settle somewhere else? The book may include histories of the 19th century, consider tragedies and movements activated by political events in the 20th century, and/or look at recent events of the 21st century. Push and pull factors are important points. While most of us may be influenced in a negative way by the current happenings in Eastern Europe, the Russian invasion and resulting tragedies also demonstrate some very positive human traits – the preparedness of Ukraine’s surrounding countries to help those in need and to provide a safe place for the present.
\r\n\tWhether one looks at voluntary or involuntary migration into any country, after a period of adjustment, migrants do play a positive role. The research found that migrants contribute to the economy (food, shelter, employment, tax) and enrich a country’s cultural norms. Prerequisites for successful settlements are that the host society adopts a tolerant approach and that the migrants recognize the law and the language of the host country. Nothing is ever easy or without controversy, but I am a migrant (German Australian), and life in Australia has been relatively harmonious. Issues that could be considered in the book are multicultural societies (do monocultural societies still exist?) and theories of acculturation versus integration (settlement processes).
\r\n\tTwo further issues are very important in relation to human migration. There is climate change, global warming, and the environment, which clearly affect people’s movement. Small island populations are very concerned about rising sea levels. 2021 has also seen floods costing human lives: Turkey (August 2021), Brazil (December 2021), Chile (January 2021), and South India (November 2021), to name but a few. In Australia (March 2022), farms and whole townships in New South Wales and Queensland have been flooded for the second time in five years, and plans to resettle these towns are considered. Official and social media provide ample coverage of the events, which leads me to the next issue. There is today’s very important role of the media, of the official and social media. We are constantly bombarded with images of human war tragedies and flood victims. People in industrialized, western countries must be the best-informed populace. How far do the images and up-to-date TV news influence us, make us change our behavior, and perhaps even consider us more generous than we have been?
\r\n\tClimate change and the media are relatively new to the human migration debate, but both issues play important parts, and some interesting discussions are appreciated.
\r\n\t
Man’s health is an essential condition of his/her wellbeing, self-fulfillment and an active creation [1, 2]. However, throughout the world, there is a great number of people suffering from different diseases. A part of them is connected with the process of gestating and bearing a child, many of them are a result of poverty, and some others are a consequence of aging [3]. Nowadays, many scientists define the reason for hereditary disease growth as a result of that mankind has gone out of control of natural selection. For instance, at the end of the nineteenth century in Russia, 85% of infants who were born in summer died [4]. The reason for most children’s death was intestinal infections and mothers’ employment in agricultural works that decreased their care for the child. At present, infant mortality has fallen, but a lot of diseases have emerged. They may be an effect during pregnancy, some chronic diseases have exacerbates in the mother, or she has had infectious diseases, experienced the acute stress, etc. The mother for the child is a natural environment in the course of development, and her health, of course, determines his/her health. Maternal organism provides everything the child needs in and develops in [5].
\nThe extragenital and chronic genital pathology exerts a significant influence upon pregnancy outcome for the fetus [6]. Among the factors of adverse effect on the fetus, researchers point out chronic hypoxia due to the disturbance of utero-placental blood circulation, the sympathetic-adrenal system insufficiency, fetal growth retardation, immaturity, the disturbance of function of cardiovascular and respiratory systems. Consequently, there appears a risk of the premature termination of pregnancy and birth of a premature baby [7]. Fetoplacental insufficiency is a complex of disturbances of placenta functions (transport, trophic, endocrine and metabolic) caused by morphofunctional changes in it and utero-placental blood circulation disturbance [8]. Placental insufficiency is a cause of the development disturbance and intrauterine hypoxia of the fetus and pathological statuses and diseases of a newborn baby.
\nAt present, fetal hypoxia occupies a leading place in the structure of the reasons for perinatal mortality (from 40 to 70%) as well as central nervous system impairments in the fetus or a newborn (from 30 to 80%), which in turn lead to different disturbances of the somatic and neuromental development of children. At that, the degree of the severity of these pathological deviations depends upon the duration and severity of intrauterine hypoxia [9]. The chronic fetal hypoxia, fetal infection and birth trauma are main reasons for the perinatal lesion of central nervous system and the strongest stress factor [10, 11]. Fetoplacental insufficiency may arise throughout pregnancy but complications for the fetus manifest mainly during the third trimester. At delivery, fetal asphyxia progresses often in mothers with chronic fetoplacental insufficiency. The reason for that is an acute and chronic hypoxia of the fetus [12]. Newborn children have the central nervous system disturbances, changes in reflex excitability, cyanosis, bradycardia and so on [13]. The newborn children, whose mothers suffer from fetoplacental insufficiency, are born in the state of severe asphyxia in 10% of cases, and 81% experience a pathological course of an early neonatal period [14, 15].
\nIn Russia, maternal toxemia during the first half of pregnancy occurs in 50% of women, late toxicosis in 2–30% of pregnant and parturient women [16]. Late gestosis represent a symptom complex of multiorgan and multisystem insufficiency, which manifest clinically more often from the 20th week of pregnancy and end immediately at birth or later after delivery [15]. The disturbances of mental, emotional and physical development are found in 20% of newborns from mothers with late gestosis; child morbidity rises considerably [17].
\nA number of investigations have shown that children born after pregnancy with gestosis have perinatal brain lesion, neurological complications, dysontogenesis, physical and neuromental development retardation, minimal brain dysfunction and immature indices of electroencephalogram [18]. Premature discharge of amniotic fluid is considered as an amniotic fluid release due to the rupture of membranes before the beginning of childbirth regardless of duration of gestation [19]. About 35% of premature labor is accompanied by premature discharge of amniotic fluid [20].
\nAmong risk factors of premature discharge of amniotic fluid, there are aborts in an anamnesis (48%), inflammatory processes of genitals (33%), extragenital infectious diseases (12%), anomalies of the bone pelvis (8.5%) and hydramnion (3.4%). In case of premature discharge of amniotic fluid, complications during the childbirth and postpartum period increase considerably: birth abnormalities (16%), bleeding during the postpartum and early postpartum periods (12.5%) and so on [21, 22].
\nThe growth of the incidence of dystocia is explained by the increase of a number of reasons leading to the development of that pathology. Central nervous system dysfunction underlies dystocia, namely: disturbance of equilibrium of the sympathetic and parasympathetic divisions, somatic and genital diseases, endocrine disorders, flat fetal bladder and discrepancy between the fetus size and the mother’s pelvis. Quite often, the reason for that anomaly is an undue and untimely prescription of stimulating-delivery remedies [23].
\nAmong the peculiarities of neonatal period in children from mothers with weakness of labor activity, there is a decrease of a favorable outcome of early adaption by newborns alongside with the prevalence of the perinatal lesion of central nervous system [24]. In many works, one points out a considerable influence of risk factors during the pre- and perinatal periods on the development of the cerebrum on the whole and higher cortical functions, which enhance the heterochrony of functional systems maturation [25]. The influence of the health of pregnant women on the somatic and mental health of infants is out of doubt. However, it is noteworthy that the totality of data evidence that in the long run, the mother’s diseases lead to an inadequate nutrition of a baby in the course of gestation and oxygen anoxemia. During the antenatal and, particularly, postnatal periods, again, the influence of the mental health of the mother on the mental health of children is less obvious and mediated, as it involves both genetic and environmental factors.
\nAfter birth, the child is connected with the mother physiologically and psychologically. During the first two living years, the mother’s influence on his or her development almost overlaps all the other factors [26]. Even if the child gets any diagnosis at birth, in many cases there may come recovery under the adequate care of him or her [27]. The child’s brain is extremely flexible during the first year of life that is why even traumas can be jugulated under quality care of him or her [28]. According to the modern concepts, the emotional connection between the child beginning from the first years of life and the mother is a major factor of his/her healthy development [29]. One should accept that it is the mother who is a main source of signs forming the emotional-informative environment of the child at early stages of his life [30].
\nAccording to Bowlby [31], a close relationship forms between the child and an adult caring during the first 2 years. They are built on the basis of the mutual direction to each other: the child seeks the contact, and the mother responds to it. That kind of behavior is determined biologically and is reasonable evolutionally, since in early days after birth, the child has to find the one who will defend and guard him [32]. According to the theory of attachment, the quality of the formed attachment depends directly on the child’s parent who may take care of him in a different way. Ainsworth with co-authors [33] observed the communication of 26 mothers and their children aged one and a half years old during 1 year. As an indicator of attachment, they evaluated the child’s behavior at the moment of the mother’s arrival and departure.
\nBased on the observations, three types of children’s reactions are described, which correspond to three types of attachment of the child to the mother. Ainsworth calls them anxious-avoidant (A), secure (B) and anxious-resistant or ambivalent (C) types.
\nThe important thing is that children with secure attachment grow into adults who will care for their health and take the responsibility for that. On the contrary, children brought up under the circumstances of insecure attachment often grow into people depending on pernicious habits [34]. The emotional behavior of the mother is predetermined considerably by her emotional intelligence [35, 36, 37, 38]. The ability to realize and ponder over one’s own and others’ emotions, of course, implies numerous consequences, first of all, in a person’s behavior. Due to that, the interrelation between emotional intelligence and attachment degree is of absolute interest [29, 33, 39, 40]. This is especially significant, since attachment involves the phenomena, which in the real life a person verbalizes seldom. It is difficult to imagine the mother who says by herself: “I accept my child”, or “I support and I do not ignore my child”. Attachment to the child is an intimate feeling being close to the instinct [31], and a person does not speak to himself or herself about its details.
\nWe assume that one of the most important parameters influencing the child’s health is a level of the emotional maturity of the mother. It manifests in the high emotional intelligence and emotional attachment to the child. We set the task to evaluate the state of health of the mother and child at birth, and the probability of the diagnosis cancelation in the child at the end of the second year of life. It depends upon two characteristics of the mother: emotional intelligence and the degree of attachment to the child.
\nIn Russia, quality examination of the child is fulfilled after birth in the maternity hospital, and a major part of children gets one or the other diagnosis. Another attending doctor may cancel the diagnosis of the child, if the child’s status has been normalized. At that, by the end of the first and, quite often, second year of life, medical specialists cancel children’s diagnoses made earlier [27]. To a considerable extent, the child’s status change is determined by efficient actions of caring persons, mainly, the mother [41]. It is the mother who in the majority of families takes the child to a doctor and carries out all the necessary directions for the rehabilitation. In that situation, her involvement in the process of the child’s health recovery impacts substantially on the positive prediction of his/her recovery provided that the disease is not genetic but determined by the peculiarities of intrauterine development and birth.
\nThe sample consisted of 100 mother-child dyads. There were 48 girls, 52 boys and 100 mothers. Among children, there were 50 children aged under 1-year-old (27 boys and 23 girls) and 50 children at the age of 1–2 years old (25 boys and 25 girls).
\nThe experimental sample was selected by means of randomization, that is, by the random selection strategy or subjects distribution when all the subjects had an equal chance to enter the group. It provided internal validity and controlled the blending effect. The present study was carried out in an urban polyclinic for children in a little town of the European part of Russia.
\nThe complex assessment of the children’s health status was based on the individual medical records. The mothers filled the questionnaire evaluating the mother’s relation to her child during the first 2 years of life [42] and the questionnaire aimed at assessing the emotional intelligence level [43]. The questionnaire evaluating the mother’s relation to her child includes four scales: sensitivity-insensitivity; attachment-rejection; support-ignoring and efficiency-intervention. The questionnaire assessing emotional intelligence level includes three scales: interpersonal emotional intelligence (EI), intrapersonal EI, emotions understanding, emotion management, some subscales and aggregate indicator of EI. It was showed earlier that both questionnaires were valid and reliable [42, 43].
\nThe complex assessment of the children’s state of health was based on six main indicators (criteria) of health [16]. These indicators are used by all doctors in the state clinics in Russia for child health assessment. We used the results of the doctor’s assessments from the individual records of the children. The first criterion: peculiarities of ontogeny (individual development) described according to the genealogical, biological and social anamnesis. The second criterion: a degree of physical development and its harmoniousness. The physical development of the child was assessed by means of the comparison of individual indicators (body length and weight, chest circumference, etc.) and age standards. At that, body length was the most informative and leading feature in the evaluation of physical development. It was important not only to solve the question of correspondence of the physical development indicators of the child to his/her age but also to assess the harmoniousness of his/her development.
\nThe third criterion: a level of nervous and mental development of the child depends upon both central nervous system state of the child, musculoskeletal system and the environment effect.
\nThe fourth criterion: a level of organism resistance assessed by the quantity of acute diseases during the year preceding the examination. According to this criterion, the children were divided into two groups: with good resistance of organism (having had no diseases during a year, or having had diseases from one to three times); with a lower resistance of organism (having had diseases more than four times a year). The fifth criterion: a level of the functional state of organism based on the aggregate of results of laboratory and instrumental examinations of the child (pulse rate, breath, hemoglobin content in the blood and so on), analysis of his or her behavior and adaptive capabilities. The mother accumulated knowledge about the child’s behavior during everyday contact with him or her. The following parameters were assessed during the observation of the child: emotional state, mood, sleep, wake, appetite and the nature of relationships with children and adults, at an older age—the ability to concentrate, attention and fatigability. It was important to take into account individual peculiarities of behavior.
\nThe sixth criterion: the presence or absence of chronic diseases or congenital malformation.
\nBased on the complex assessment of the above-mentioned criteria, five groups of health were distinguished:
\nGroup I: healthy children having no abnormalities according to all the six criteria.
\nGroup II-A: children having abnormalities according to the first criterion only (ontogeny peculiarities).
\nGroup II-B: children having some functional disorders (including behavior), physical and/or nervous and mental developmental disturbances (or without any of them) and frequent illnesses.
\nGroup III: children having chronic diseases at the stage of compensation, that is, without any disorders of health.
\nGroup IV: children having chronic diseases exacerbating 2–4 times per year, at the stage of subcompensation.
\nGroup V: children having chronic diseases at the stage of decompensation.
\nWe received permits from the children’s parents to use the information from their individual medical records. Mothers with children went to the doctor (in Russia mothers of the first-year-old children show their children to the doctors each months) and filled in the questionnaires when the doctor analyzed the health of the child. Then they showed the doctor’s records for the researchers. They received the psychological consultations if they participate in the investigation.
\nFor the statistical analysis, the program SPSS-22 was used.
\nThe analysis of the data about the pregnancy of the mothers having first- and second-year-old children showed the following results. About 62% of the mothers of first-year-old children and 66% of the mothers of second-year-old children had a first pregnancy. About 26% of the women had a second one. A total of 6% of the mothers of children aged under one-year-old and 2% of the mothers of children at the age of 1–2 years old had a third pregnancy; 4 and 2% correspondingly—a fourth and fifth one, and as little as 1% of the mothers of second-year-old children had a sixth pregnancy.
\nInterpreting the data about planned and unintended pregnancy, it was noteworthy that the child was “planned and desired” for 72% of the mothers of first-year-old children and 62% of the mothers of second-year-old children. The baby was “unexpected but desired” for 28 and 38% of the women correspondingly. At that, the majority of the mothers (72%), having children aged less than 2 years old, experienced joy, having learned about their pregnancy. Thus, the total sample consisted of 200 subjects under test; there were 50 dyads of “the mother-the first-year-old child” (mean age of the mothers is 24.5 ± 5.6 years old) and 50 dyads of “the mother-the second-year-old child” (mean age of the mothers is 25.5 ± 4.9 years old).
\nBased on Table 1, in the maternity hospital, the first-year-old children at the moment of examination get approximately the same number of diagnoses: two ones per child on the average. During the first year of living, the number of diagnoses diminishes; and there is one diagnosis per two second-year-old children. That fall of incidence is statistically significant. There are no significant differences in these parameters for the boys and girls.
\nParameters | \nThe number of diagnosis | \n|||||
---|---|---|---|---|---|---|
The first-year-old children | \nThe second-year-old children | \n|||||
All children | \nGirls | \nBoys | \nAll children | \nGirls | \nBoys | \n|
The number of diagnoses made in the maternity hospital | \n2.0 ± 1.1 | \n2.0 ± 1.1 | \n2.2 ± 1.0 | \n2.4 ± 1.5 | \n2.6 ± 1.7 | \n2.2 ± 1.3 | \n
The number of diagnosis made by a local doctor | \n1.2 ± 1.1 | \n1.2 ± 1.1 | \n1.2 ± 1.2 | \n0.6 ± 0.9**\n | \n0.8 ± 0.9 | \n0.7 ± 1.0 | \n
The number of diagnosis of the children made in the maternity hospital and by local doctors.
Differences between of the first and second old children р = 0.95.
р = 0.99 (there and late Т-criterion).
In spite of the incidence fall, valid differences in the number of the children in the different groups of health at the first and second years of life are not found. This is accounted for that many second-year-old children are identified as group 2A. It includes the children who have no diseases and are almost healthy except these or other peculiarities of the anamnesis at the present moment. As described further, almost all of them have abnormalities owing exactly to the biological anamnesis of the mother.
\nThe obtained results required a more in-depth consideration of morbidity (Table 2). The data (in %), obtained and presented in Table 2, show that the most widespread diseases are intrauterine hypoxia and physiological jaundice diagnosed in the children during their stay in the maternity ward. Almost all the children have one or the other disease at birth (90% of the first-year-old children, 96% of the second-year-old children). By the end of the first year of life, the diagnoses are canceled in 40% of the children, and in 60% of the children during the second year of life.
\nThe name of the diagnosis of the child made in the maternity ward | \nThe first-year-old children | \nThe second-year-old children | \n
---|---|---|
1. Intrauterine hypoxia | \n64 | \n52 | \n
2. Physiological jaundice | \n42 | \n60 | \n
3. Conjugation jaundice | \n4 | \n6 | \n
4. Risk group due to perinatal encephalopathy | \n15 | \n8 | \n
5. Perinatal damage of central nervous system (CNS) | \n4 | \n6 | \n
6. Excitation syndrome | \n2 | \n2 | \n
7. Toxic erythema | \n12 | \n6 | \n
8. Hemorrhage in the skin | \n12 | \n20 | \n
9. Prematurity | \n0 | \n2 | \n
10. Morphofunctional immaturity | \n2 | \n2 | \n
11. Edema syndrome | \n2 | \n2 | \n
12. Low birth weight | \n2 | \n6 | \n
13. Large child | \n8 | \n6 | \n
14. Asphyxia of low level | \n4 | \n4 | \n
15. Asphyxia of mean level | \n4 | \n0 | \n
16. Asphyxia of high level | \n2 | \n0 | \n
17. Intrauterine growth restriction by hypotrophic type | \n4 | \n2 | \n
18. Cardiopathy | \n4 | \n2 | \n
19. Pathological loss of body weight | \n2 | \n8 | \n
20. Umbilical hernia | \n0 | \n2 | \n
21. Chin tremor | \n0 | \n2 | \n
22. Low muscle tones | \n0 | \n2 | \n
23. Muscle hypertonus | \n0 | \n2 | \n
24. Respiratory distress syndrome of type 1 | \n0 | \n2 | \n
25. Hypoxic damage of CNS | \n0 | \n2 | \n
26. The syndrome of CNS depression | \n0 | \n2 | \n
27. Oxygen-dependent child | \n0 | \n2 | \n
28. Depressed reflexes | \n0 | \n2 | \n
29. Mammary glands engorgement | \n0 | \n4 | \n
30. Right parietal cephalohematoma | \n0 | \n4 | \n
31. Perinatal contact with chronic hepatitis C virus | \n2 | \n2 | \n
32. Umbilical cord entanglement around the neck | \n2 | \n2 | \n
33. Nappy rash | \n0 | \n2 | \n
34. Hyperbilirubinemia | \n0 | \n2 | \n
35. The right-side dacryocystitis | \n0 | \n2 | \n
36. The left-side dacryocystitis | \n0 | \n2 | \n
37. The left-side flat valgus foot | \n2 | \n2 | \n
38. Reduced film of the tear duct | \n0 | \n4 | \n
39. Papilloma of the left areola | \n2 | \n0 | \n
40. Urinary tract infection | \n2 | \n0 | \n
41. Ankyloglossia | \n2 | \n0 | \n
42. The right clavicle fracture | \n2 | \n0 | \n
43. Polycythemia | \n2 | \n0 | \n
44. Intrauterine hypotrophy | \n2 | \n0 | \n
The children’s diagnoses made in the maternity hospital (%).
The data, obtained and presented in Table 2, show that the most widespread diseases are intrauterine hypoxia and physiological jaundice diagnosed in the children during their stay in the maternity ward. Almost all the children have one or the other disease at birth (90% of the first-year-old children, 96% of the second-year-old children). By the end of the first year of life, the diagnoses are canceled in 40% of the children, and in 60% of the children during the second year of life. These disorders are the typical one during pregnancy in many countries [3, 15, 21, 24, 44, 45]. This is a typical distribution of neonatal morbidity in Russia [12, 41].
\nIn Table 3, there are data about the number of canceled and non-canceled diagnoses for each of the diseases made by a local doctor earlier during the first 2 years. It is evident that during the second year of life already, a major part of the children come to the healthy group (retaining health group II-A because of the burdened anamnesis). There are no differences in this parameter between the boys and girls.
\nThe name of the diagnosis of the child made by local doctor | \nThe ratio of the canceled and non-canceled diagnoses of children | \n|||||
---|---|---|---|---|---|---|
The first-year-old | \nThe second-year-old | \n|||||
Number of diagnoses | \nCanceled | \nNon-canceled | \nNumber of diagnoses | \nCancelled | \nNon-canceled | \n|
Perinatal encephalopathy | \n86 | \n24 | \n62 | \n80 | \n64 | \n16 | \n
Moving disorders | \n54 | \n20 | \n34 | \n48 | \n36 | \n12 | \n
Excitation syndrome | \n6 | \n2 | \n4 | \n8 | \n4 | \n4 | \n
Anemia | \n2 | \n0 | \n2 | \n4 | \n0 | \n4 | \n
Atopic dermatitis | \n4 | \n2 | \n2 | \n4 | \n0 | \n4 | \n
Flat valgus foot | \n2 | \n0 | \n2 | \n0 | \n0 | \n0 | \n
Pyelectasis | \n2 | \n0 | \n2 | \n0 | \n0 | \n0 | \n
Dysplasia of the hip joints | \n2 | \n0 | \n2 | \n0 | \n0 | \n0 | \n
Hypotrophy of the 1,2,3 degrees | \n0 | \n0 | \n0 | \n6 | \n6 | \n0 | \n
Inguinal hernia | \n0 | \n0 | \n0 | \n4 | \n0 | \n4 | \n
Paratrophy | \n2 | \n2 | \n0 | \n2 | \n0 | \n2 | \n
Cardiopathy | \n2 | \n0 | \n2 | \n0 | \n0 | \n0 | \n
Little anomaly of heart development | \n0 | \n0 | \n0 | \n2 | \n0 | \n2 | \n
The ratio of the canceled and non-canceled diagnoses for each of the diseases made by a local doctor.
Thus, after the analysis of the medical histories of the children, one can say that the percentage of the healthy children at birth is very small. But the situation changes substantially during the first 2 years of living: a major part of the children’s diagnoses are canceled by a local doctor. That is why it is highly important to explore the reasons, which enhance the probability of recovery during the most flexible period of the child’s life.
\nBy the end of the first 2 years of life, a major part of the children passes to the group of healthy children. There appears a question of particular peculiarities of the psychological state of the mother that might be predictors of positive changes in the child’s health at that time. Since morbidity at birth is often accounted for anomalies during gestation and childbirth, then the comparison of biological anamnesis of the mother and peculiarities of the child’s health during the first years of living is of interest. Of course, not only the mother’s health and diseases predetermine that change but they make their contribution to it. According to our data, the mothers of the first- and second-year-old children do not differ between one another in the parameters of biological anamnesis.
\nFurther, we have fulfilled correlation analysis (the Spearman’s coefficient) aiming to identify relations between the children’s health parameters and parameters of biological anamnesis of the mothers. There is a positive connection between the number of the diagnoses in the first- and second-year-old children during their stay in the maternity ward and perinatal pathology factors of the mother (r = 0.336, p ≤ 0.001 for the first-year-old children; r = 0.226, p ≤ 0.05 for the second-year-old children). Besides, the interrelation between the number of perinatal pathology factors and health group of the first- and second-year-old children is observed (r = 0.243, p ≤ 0.02 for the first-year-old children; r = 0.281, p ≤ 0.01 for the second-year-old children). There is no significant interrelation between the number of the diagnoses in the second-year-old children and perinatal pathology factors of their mothers. That is connected with that a part of diagnoses has been canceled by the moment of the examination of the child. However, the number of the diagnoses in the first-year-old children made by a local doctor is validly connected (r = 0.478, p ≤ 0.001) with the quantity of perinatal pathology factors identified during their mothers’ pregnancy.
\nThere is a positive interrelation between the health group type of the second-year-old children and the presence of abortions made before by their mothers (r = 0.213, p ≤ 0.05). One should point out that no similar relation is found in the first-year-old children. The obtained data evidence a negative effect of abortions on the children’s health. It manifests and is detected after some time only. The results obtained in correlation analysis correspond to the results of single-factor analysis of variance. It has shown that exactly the number of the perinatal pathology factors of the mother influences the number of the children’s diagnoses made in the maternity hospital (where F = 9.565, p = 0.003 for the first-year-old children; F = 5.014, p = 0.030 for the second-year-old children).
\nWe have analyzed 28 parameters indicating the presence of pathology in the mother. Based on them, the control of the state of health and prevention of abnormalities are performed in the children who have risks of getting central nervous system disorders at the maternity house. The analysis reveals that only 8% of the mothers of first-year-old children and 14% of the second-year-old children are almost healthy. About 74 and 62% of the mothers have different extragenital diseases. The obstetric anamneses of 24% of the mothers, having first-year-old children, are burdened with abortions, 22% of the mothers—having second-year-old children. The anamneses of 8 and 10% of the women correspondingly are burden with miscarriage. The current pregnancy of 34% of the mothers of first-year-old children and 22% of the mothers of second-year-old children is complicated by the threat of abortion. In 18 and 10% of the mothers of children aged under 2 years old, it is accompanied by placental insufficiency. In 14% of the women, there is an immunological incompatibility of blood of the mother and the fetus. Besides, 6% of the women having first-year-old children and 2% of the women having second-year-old children have got the symptoms of fetal hypoxia. About 14% of the mothers of first-year-old children and 10% of the mothers of second-year-old children are characterized by weakness of labor. The dominant factors in the structure of extragenital anomalies of the mothers of first- and second-year-old children (as in some other investigations) are iron deficiency anemia (26%), kidney diseases (28 and 30%) and vegetovascular dystonia (24 and 20%).
\nIn our further analysis, all the factors are divided into three groups according to the period of impact:
Detrimental factors during the progenesis.
Adverse factors during the antenatal period.
Adverse factors during the birth period (the intranatal period).
We cannot detect any role of factors in progenesis, since we have observed the women regarding the gestation responsibly and regularly consulting with a gynecologist during their pregnancy. Only 4% of the mothers of first-year-old children smoke; and among the mothers of second-year-old children, there are no women with bad habits. About 4% of the mothers of children aged under one-year-old and 12% of the mothers of second-year-old children have gynecological diseases in the anamnesis.
\nBut we have been able to show the influence of the factors of perinatal pathology in the mother during the antenatal period on the future health of the child. The most significant factors of risk of the child’s morbidity are the following: the threat of abortion (34% of the first-year-old children’s mothers and 22% of the second-year-old children’s mothers), anemia (26%), vegetovascular dystonia (24 and 20%), kidney diseases (28 and 30%) and chronic fetoplacental insufficiency (18 and 10%). During the intranatal period, the significant risk factors of perinatal pathology of the mothers, exerting influence upon the health of the first- and second-year-old children, are episiotomy (20 and 26%), cesarean (26 and 16%), premature rupture of membranes (20 and 18%) and weakness of labor activity (14 and 10%). We have not found any substantial differences in the pathology of the mothers of two groups. But this distribution shows the typical situation for pregnant women in Russia [25].
\nCorrelation analysis of the results about the interrelation of the number of diagnoses in the first-year-old children, made by a local doctor, with perinatal anomaly factors during the antenatal period is in Table 4. We have found the significant relation of the children’s morbidity with fetoplacental insufficiency during pregnancy (r = 0.444, p < 0.001) as well as with threat of abortion (r = 0.379, p < 0.01) and gestosis in the mother during pregnancy (r = 0.353, p < 0.01). We have revealed the close positive relation between the first-year-old children’s health deterioration and iron deficiency anemia (r = 0.330, p < 0.02) and kidney diseases (r = 0.276, p < 0.05) through the mother. That is, the more diseases the mother has, the higher number of diseases the first-year-old children have.
\nMother’s perinatal pathology | \nThe number of diagnoses, made by a local doctor | \n|
---|---|---|
The first-year-old children | \nThe second-year-old children | \n|
Fetoplacental insufficiency | \nr = 0.444, p < 0.001 | \np > 0.05 | \n
Threat of abortion | \nr = 0.379, p < 0.01 | \np > 0.05 | \n
Gestosis | \nr = 0.353, p < 0.01 | \np > 0.05 | \n
Iron efficiency anemia | \nr = 0.330, p < 0.02 | \nr = 0.382, p < 0.01 | \n
Kidney diseases | \nr = 0.276, p < 0.05 | \nr = 0,281, p < 0.05 | \n
Varicosity | \np > 0.05 | \nr = 0.322, p < 0.02 | \n
Correlations between the number of diagnosis and factors of the mother’s perinatal pathology.
There is no significant correlation relationship between the number of diseases of the second-year-old children and perinatal pathology factors of the mother during the antenatal period. However, significant interconnection is found between the number of diseases of the second-year-old children and iron efficiency anemia (r = 0.382, p < 0.01), varicosity (r = 0.332, p < 0.02), and the mother’s kidney diseases (r = 0.281, p < 0.05). The analysis of the results about the interrelation of the number of diagnoses in the first-year-old children (by a local doctor) with the perinatal pathology factors of the mother during the intranatal period is in Table 5. It has revealed the significance of that dependence with weakness of birth activity (r = 0.354, p < 0.001). There is no similar association in the second-year-old children.
\nPathology factors of the mother during the intranatal period | \nThe number of diagnoses of children | \n|
---|---|---|
The first-year-old children | \nThe second-year-old children | \n|
weakness of birth activity | \nr = 0.354, p < 0.01 | \np > 0.05 | \n
premature childbirth | \np > 0.05 | \nr = 0.633, p < 0.001 | \n
The interrelation of the number of diagnoses of children (by a local doctor) with the perinatal pathology factors of the mother during the intranatal period.
We have revealed (Table 5) close interrelation between the number of diagnoses, made by a local doctor, and premature childbirth of the mother (r = 0.663, p < 0.001) for the second-year-old children.
\nOne might suppose that the degree of influence of those factors upon children of different sex would be different (Table 6). We have found close positive interconnection between the number of the first-year-old girls’ diagnoses and their mothers’ diseases of the cardiovascular system (r = 0.581, p < 0.01), iron deficiency anemia and kidney diseases (r = 0.529, p < 0.02; r = 0.463, p < 0.05) as well as fetoplacental insufficiency (r = 0.489, p < 0.05). As for the boys, there is a positive relationship between the number of diagnoses and gestosis in the mother during pregnancy (r = 0.400, p < 0.001), the threat of premature childbirth (r = 0.374, p < 0.05), immunological incompatibility of blood of the mother and the fetus (r = 0.457, p < 0.01) and kidney diseases (r = 0.391, p < 0.01).
\nThe antenatal pathology factors of the mother | \nThe number of diagnoses made by a local doctor | \n|||
---|---|---|---|---|
Number of diagnoses of boys and girls (by a local doctor) | \nThe first-year-old children | \nThe second-year-old-children | \n||
Girls | \nBoys | \nGirls | \nBoys | \n|
Fetoplacental insufficiency | \nr = 0.489, p < 0.05 | \np > 0.05 | \np > 0.05 | \np > 0.05 | \n
Gestosis | \np > 0.05 | \nr = 0.400, p < 0,001 | \np > 0.05 | \np > 0.05 | \n
The threat of premature childbirth | \np > 0.05 | \nr = 0.374, p < 0.05 | \np > 0.05 | \np > 0.05 | \n
Diseases of the cardiovascular system | \nr = 0.581, p < 0.01 | \np > 0.05 | \np > 0.05 | \np > 0.05 | \n
Iron deficiency anemia | \nr = 0.529, p < 0.02 | \np > 0.05 | \nr = 0.509, p < 0.02 | \nr = 0.494, p < 0.01 | \n
Kidney diseases | \nr = 0.463, p < 0.05 | \nr = 0.391, p < 0.01 | \np > 0.05 | \nr = 0.484, p < 0.01 | \n
Immunological incompatibility of blood | \np > 0.05 | \nr = 0.457, p < 0.01 | \np > 0.05 | \nr = 0.508, p < 0.001 | \n
Edema | \np > 0.05 | \np > 0.05 | \nr = 0.780, p < 0.001 | \np > 0.05 | \n
The interrelation of the number of diagnoses of boys and girls (by a local doctor) with the perinatal pathology factors of the mother during the antenatal period.
The analysis of the results about the relationship of the number of diagnoses in the second-year-old girls with the perinatal pathology factors during the antenatal period reveals significant dependence between the child’s morbidity and iron deficiency anemia and edema in the mother during pregnancy (r = 0.509, p < 0.02; r = 0.780, p < 0.001 correspondingly). It is noteworthy that close relationship is found between the number of diseases in the second-year-old boys and kidney diseases in the mother (r = 0.484, p < 0.01). Besides, significant positive relation is identified between the number of diseases in the second-year-old boys and negative Rh factor of the mother (r = 0,508, p < 0.001), and iron deficiency anemia (r = 0.494, p < 0.01).
\nThe result of correlation analysis between the antenatal pathology factors of the mother and the number of diagnoses, made by a local doctor separately for the boys and girls, are in Table 6.
\nFurther, we carry out correlation analysis aimed at identifying the interrelation of the number of diagnoses in the boys and girls, made by a local doctor, with the perinatal anomaly factors during the intranatal period (Table 7).
\nThe intranatal pathology factors of the mother | \nOf the number of diagnoses made by a local doctor | \n|||
---|---|---|---|---|
The first-year-old children | \nThe second-year-old children | \n|||
Girls | \nBoys | \nGirls | \nBoys | \n|
Episiotomy | \nr = 0.552, p < 0.01 | \np > 0.05 | \np > 0.05 | \np > 0.05 | \n
premature rupture of membranes | \nr = 0.586, p < 0.01 | \np > 0.05 | \np > 0.05 | \np > 0.05 | \n
weakness of labor activity | \np > 0.05 | \nr = 0.457, p < 0.01 | \np > 0.05 | \np > 0.05 | \n
the defect of the placenta | \np > 0.05 | \np > 0.05 | \nr = 0.780, <0.001 | \np > 0.05 | \n
manual control of the uterine cavity | \np > 0.05 | \np > 0.05 | \nr = 0.453, p < 0.05 | \np > 0.05 | \n
The interrelation of the number of diagnoses of boys and girls (by a local doctor) with the perinatal pathology factors of the mother during the intranatal period.
Close positive connection reveals between the number of diagnoses in the first-year-old girls, made by a local doctor, and episiotomy (r = 0.552, p < 0.01), and premature rupture of membranes in the mother (r = 0.586, p < 0.01). There is association between the number of diagnoses of the first-year-old boys and weakness of labor activity of the mother (r = 0.457, p < 0.01).
\nThe analysis of the results about the interconnection between the number of diagnoses in the second-year-old girls and the perinatal pathology factors during delivery reveals significant dependence, the defect of the placenta (r = 0.780, p < 0.001) and manual control of the uterine cavity at childbirth (r = 0.453, p < 0.05). There is no significance of the same associations in the second-year-old boys. Subsequently, the health of children aged under 2 years old changes significantly during the first 2 years of life. The less factors of perinatal anomalies the mother has got, the more positive prognosis with regard to the child’s health is. The most widespread diagnoses of the child at birth are encephalopathy and syndrome of motor disorders. The leading groups of the factors of perinatal pathology of the mother are extragenital diseases and birth activity complications. The change of the relationship between the number of diagnoses of the children at the age of the first 2 years old and the perinatal pathology factors of the mother is different in the boys and girls.
\nMaternal pathology leads to low level of oxygen during pregnancy and followed the different child disorders [46].
\nIt is obvious that not only perinatal pathology contributes to the health of the child at an early age [46]. Moreover, the success of child care during the first years of life is determined by psychological features of the mother. And that is why we will address the assessment of the influence of emotional reaction of the mother to the child’s health status. Univariate analysis of variance is carried out to evaluate the influence of independent variable “the degree of the mother’s attachment to the child” [47, 48] on the future possible cancelation of the child’s diagnosis by a local doctor. The significant influence is obtained for one scale of the questionnaire only. Based on the results of the research, the degree of acceptance of the child (the acceptance-rejection scale) by the mothers of first-year-old children exerts influence on the probability of cancelation of the child’s diagnosis made by a local pediatrician (F = 6.829, p < 0.003) during the first 2 years.
\nThere are no differences between the mothers of first- and second-year-old children according to the degrees of attachment. About 54% of the mothers of each group are characterized by low degree of attachment; 44 and 42% correspondingly are characterized by mean degree. Only 2 and 4% of the mothers of first- and second-year-old children have high degree of attachment. No mothers with maternal deprivation are identified. Positive prognosis in terms of health of the first-year-old children depends upon the degree of acceptance of the child by the mother: the higher the value on the acceptance-rejection scale is, the better the child’s health is. Our data point to the absence of differences in the features of emotional intelligence of the mothers of the first- and second-year-old children. The similarity of emotional intelligence of the mothers is explained by that they represent the same social environment.
\nThe research results show that the majority of the mothers are characterized by low level of the capability to understand and control their own and other emotions as well as of interpersonal, intrapersonal and general emotional intelligence. There are no mothers with high level of emotional intelligence. Probably, that is why we do not find any association between emotional intelligence of the mother and the probability of cancelation of the child’s diagnosis either in variance or correlation analysis. At the same time, in a sample of the mothers of second-year-old children, univariate analysis of variance reveals the influence of independent variables “understanding of other emotions” and “general emotional intelligence” on dependent variable “degree of attachment” (F = 2.115, p = 0.051; F = 2.618, p = 0.029). The better the understanding of other emotions and general emotional intelligence are, the higher the degree of attachment is. We have detected the influence of independent variables “understanding of other emotions”, “control of expression” and “control of one’s own and other emotions” on dependent variable “sensitivity-insensitivity” (correspondingly, F = 3.741, p = 0.002; F = 3.714, p = 0.003; F = 2.747, p = 0.015). The higher the values of the structural components of emotional intelligence are, the more efficient the mother is. That is, she respects for the child’s independency to a greater extent.
\nOur data refer only to those women who led predominantly healthy lives before pregnancy and actively cared for the child immediately after his (her) birth. It is consistent with a large number of studies showing the dependence of the health level of the child at birth on both the mother’s health before pregnancy and her pathology that arose during pregnancy and during childbirth [1, 7, 18, 19]. Our data show that the acceptance of the child is the main psychological factor that contributes to the recovery of the child by the end of the second year his (her) life. At the same time, there are no significant effects between the parameters of emotional intelligence and the child’s recovery. Although the parameters of emotional intelligence affect the sensitivity of the mother to the child needs. Perhaps in another sample, in which mothers with high level of the emotional intelligence would participate, such connections will be found.
\nAlmost all the children at birth have one or the other diagnosis (96% of the first- and second-year-old children). But by the end of the first year of life, diagnoses are canceled in 40% of the children by a local doctor, and during the second year of life—in 60% of the children. The most widespread diagnose of the child at birth is perinatal encephalopathy and syndrome of motor disorders.
\nOnly 8% of the first-year-old children’s mothers and 14% of the second-year-old children’s mothers are almost healthy. The less factors of perinatal pathology there are in the mother, the more positive the prognosis with regard to the child’s health within the first 2 years of living is. The association of morbidity of the children with the factors of perinatal pathology of the mother is the most pronounced during the first year of living. During the second year of life, the boys’ health is less dependent on those factors than that of the girls.
\nThere are differences between the mothers of first- and second-year-old children according to the degrees of attachment. About 54% of the mothers of each group are characterized by low degree of attachment; 44 and 42% correspondingly are characterized by mean degree. Only 2 and 4% of the mothers of the first- and second-year-old children are characterized by high degree of attachment. No mothers with maternal deprivation have been identified. Positive prognosis with regard to the first-year-old children’s health depends upon the acceptance of the child by the mother: the higher the value on the scale of acceptance-nonacceptance is, the better the child’s health is.
\nThe degree of emotional intelligence of the mother is not associated with the probability of cancelation of the child’s diagnosis.
\nThe work was supported by the grant of the Russian Fund of the Fundamental Researches# 18-413-480007.
\nWe have no any conflict of interest.
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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. 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Heshmati",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313921/images/system/313921.jpg",biography:"Dr. Hassan Massoud Heshmati is an endocrinologist with 46 years of experience in clinical research in academia (university-affiliated hospitals, Paris, France; Mayo Foundation, Rochester, MN, USA) and pharmaceutical companies (Sanofi, Malvern, PA, USA; Essentialis, Carlsbad, CA, USA; Gelesis, Boston, MA, USA). His research activity focuses on pituitary tumors, hyperthyroidism, thyroid cancers, osteoporosis, diabetes, and obesity. He has extensive knowledge in the development of anti-obesity products. Dr. Heshmati is the author of 299 abstracts, chapters, and articles related to endocrinology and metabolism. 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He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. in Chemistry in July 2000, and his Ph.D. in Physical Chemistry in 2007 from the University of Khartoum, Sudan. In 2009 he joined the Dr. Ron Clarke research group at the School of Chemistry, Faculty of Science, University of Sydney, Australia as a postdoctoral fellow where he worked on the Interaction of ATP with the phosphoenzyme of the Na+, K+-ATPase, and Dual mechanisms of allosteric acceleration of the Na+, K+-ATPase by ATP. He then worked as Assistant Professor at the Department of Chemistry, University of Khartoum, and in 2014 was promoted to Associate Professor ranking. In 2011 he joined the staff of the Chemistry Department at Taif University, Saudi Arabia, where he is currently active as an Assistant Professor. His research interests include:\r\n(1) P-type ATPase Enzyme Kinetics and Mechanisms; (2) Kinetics and Mechanism of Redox Reactions; (3) Autocatalytic reactions; (4) Computational enzyme kinetics; (5) Allosteric acceleration of P-type ATPases by ATP; (6) Exploring of allosteric sites of ATPases and interaction of ATP with ATPases located in the cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, México. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 270 peer-reviewed papers, 32 book chapters, and 4 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:null,institution:null},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"428313",title:"Dr.",name:"Sambangi",middleName:null,surname:"Pratyusha",slug:"sambangi-pratyusha",fullName:"Sambangi Pratyusha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"CGIAR",country:{name:"France"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. 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