Adsorption capacities for zeolite NaX (pure zeolite NaX powder and binder-containing bulk material with 82.5 wt% zeolite NaX and 17.5 wt% attapulgite).
\r\n\t
",isbn:"978-1-83969-588-9",printIsbn:"978-1-83969-587-2",pdfIsbn:"978-1-83969-589-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"543783652b9092962a8fa4bed38eeb17",bookSignature:"Dr. Hamadttu El-Shafie",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",keywords:"Pollinators, Decomposers, Agricultural Intensification, Pesticides Application, Global Warming, Insect Fauna, Invasive Species, Native Species, Deforestation, Destruction of Insect Habitats, Botanical Insecticides, Biodiversity",numberOfDownloads:1237,numberOfWosCitations:0,numberOfCrossrefCitations:8,numberOfDimensionsCitations:15,numberOfTotalCitations:23,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 25th 2021",dateEndSecondStepPublish:"March 25th 2021",dateEndThirdStepPublish:"May 24th 2021",dateEndFourthStepPublish:"August 12th 2021",dateEndFifthStepPublish:"October 11th 2021",remainingDaysToSecondStep:"a year",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Associate Professor of entomology, appointed head of Department of Crop protection, then deputy dean of academic affairs, Faculty of Agriculture, University of Khartoum. At the moment he is the head of the red palm weevil research program, King Faisal University.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"El-Shafie",slug:"hamadttu-el-shafie",fullName:"Hamadttu El-Shafie",profilePictureURL:"https://mts.intechopen.com/storage/users/192142/images/system/192142.jpg",biography:"Hamadttu Abdel Farag El-Shafie is an associate professor of entomology and senior research entomologist at the Date Palm Research Center of Excellence, King Faisal University, Saudi Arabia. He is the head of IPM research program in date palm. El-Shafie obtained his B.Sc. and M.Sc. degrees from the University of Khartoum, Sudan in 1988 and 1993, respectively. He received his Ph.D. degree from University of Giessen, Germany in 2001. He was appointed head of Crop Protection Department at University of Khartoum in 2008, and then deputy dean for academic affairs at Faculty of Agriculture, University of Khartoum. He supervised 25 M.Sc. students and 5 Ph.D. students at University of Khartoum. His research interest focuses on management of field crop pests using neem biopesticides, and biology and ecology of date palm pests including mites. He also has interest in control of red palm weevil using semiochemicals. He published more than 60 research papers in international peer-reviewed journals and 10 book chapters with international publishers such as Springer, John Wiley and IntechOpen, in addition to more than 30 international conferences in the field of entomology. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"50751",title:"Industrial Zeolite Molecular Sieves",doi:"10.5772/63442",slug:"industrial-zeolite-molecular-sieves",body:'\nZeolite molecular sieves are used in industrial applications since more than 60 years, mainly as highly efficient adsorbents for separation processes in gas or liquid phase. The current market volume for molecular sieves (especially for zeolites for adsorption applications) is 150.000–200.000 t with a sales volume of 450–550 Mio. USD with an annual growth forecast up to 2020 of 3–5% [1–3]. Growth drivers are environmental protection and conservation of resources (deeper processing of crude oil, using of coal and natural gas (especially from off-shore and shale gas deposits coming [4–6]) as raw material for petrochemical products in the so-called coal-to-liquid (CTL) or gas-to-liquid (GTL) processes) [7–9].
\nZeolite molecular sieves can be applied in powder form, preferably in static applications. During the polyurethane production, zeolite 3A powder is mixed with the polyol component to enable exclusion of moisture and prevent the chemical reaction of water with the isocyanate component [10]. To support the material handling, and to avoid, for example, dust formation molecular sieve beads are used in non-regenerative applications, too. Dry sealing plug or small dry bags filled with zeolite A (or silica) [11, 12] to guaranty a dry transport or storage of humidity sensitive goods such as electronical products, leather ware, or pharmaceuticals are common [11, 12]. The application of zeolite 3A in insulating glass panes is well-known, too. By putting the adsorbent material as desiccant in the perforated spacer between the two or three window panes moisture condensation between the panes (fogging) is prevented [13]. Refrigerant drying [14, 15] is also a static adsorption process, where in the coolant circuit formed, water and acidic components are removed [14, 15].
\nBesides the mentioned application examples, shaped zeolite molecular sieve material in flowing media is used to a much larger extent. For instance, the purification of technical hydrogen (removal of nitrogen and carbon monoxide) on zeolite 5A [16], the pre-purification of raw air on zeolite NaX [17] for the cryogenic air separation or the adsorptive oxygen enrichment, for example, on zeolite type 5A [18] or LiX [19, 20] should be mentioned in this place. Applied technologies for purification and drying of natural gas are operating with zeolite molecular sieves [21] of zeolite 5A and/or NaX type [22]. In petro chemistry applications especially in steam cracking plants, light hydrocarbons are separated by low temperature rectification. To avoid ice crystal and gas hydrate formation, cracked gases have to be dried to a residual water content <1 ppm [23]. Zeolite molecular sieves of type 3A meet the requirements for that complex process [22]. For the sake of completeness, the principle of the simulating moving bed (SMB) should also be mentioned. This practically continuous liquid phase adsorption process is based on the countercurrent extraction principle [24]. The so-called Molex process, where paraffin mixtures (zeolite molecular sieve of type 5A [25, 26]) are separated, and the so-called Parex processes, where
Another field for the application of zeolite molecular sieves is the utilization of the adsorption heat during the adsorption process. Different applications such as building heating [30–32] or enhanced household devices such as dish washers [33, 34] based on the thermo-chemical energy properties of zeolites are introduced into the market.
\nThe above-mentioned examples clearly demonstrate the demand for zeolite molecular sieves with special properties depending on the different requirements in the application.
\nMany synthesis and shaping technologies for molecular sieves were developed over the last decades. Within the following descriptions, the influence of the applied synthesis and shaping methods for hydrophilic zeolite molecular sieves of zeolite A, X, and NaY on their properties, and thus, on their potential applicability in industrial adsorption processes is discussed. The procedures, materials, and recipes for the manufacturing of zeolite powders, binder-containing shapes as well as binderless shapes are described. Also compact structures such as honeycombs and multi-channel tubes are considered.
\n\nFigure 1 summarizes different manufacturing procedures and materials dealt with in this review.
\nOverview of the manufacturing of different zeolite molecular sieves (figure compact zeolite bodies [
Within the manufacturing of synthetic zeolite molecular sieves, the synthesis of the related zeolite powder is first step. There are two different principles for the synthesis of aluminum-rich zeolites in industrial processes:
\nManufacturing of highly pure crystalline zeolite powders from a synthesis gel and
Conversion of natural minerals into zeolite matter.
Usually, in the industrial production of zeolite A, X, and NaY, the sodium form is manufactured (except the zeolite LSX synthesis [36]). Therefore, different raw materials as silicon source such as silicic acid, colloidal silica, sodium silicate, or silica gel [37] are used. Possible alumina sources are alumina trihydrate, sodium aluminate, activated alumina, gamma alumina. Sodium may be obtained from sodium hydroxide which controls simultaneously the pH value [37]. A convenient way to prepare such a reactant mixture is to pour under more or less intensive stirring an aqueous solution containing the aluminum source and sodium hydroxide into an aqueous solution containing the silica source. After gel formation and generating a homogeneous mixture, the mixture is heated up to maximal 120°C at atmospheric pressure or moderate overpressure [37]. After crystallization, the zeolite suspension is filtered at temperatures between room temperature and reaction temperature [37], for example, in a filter press [38] or a centrifuge [39, 40] or a vacuum belt filter [40]. The zeolite crystals are washed directly on the filter device till a pH value between 9 and 12 [37] is achieved. If desired, the zeolite powder in its (virgin) sodium form can be ion exchanged or otherwise modified. For example, the filter cake can be suspended in a suitable salt solution and stirred at a suitable temperature. Alternatively, the exchange step is done in a column [41] or directly on the filter press [42] with a suitable salt solution at a suitable temperature. After the ion-exchange procedure is completed, the zeolite is washed as described above. Afterwards, the filter cake is dried in a direct or indirect heated thermal treatment process, as, for example, spray drying, spin flash drying, or long gap mill drying [40, 43]. The dried zeolite powder is processed in the following steps. The mother liquor from the filtration step can usually (at least to a certain extent) be reused in the following zeolite synthesis batch [37, 44].
\nThe manufacturing of zeolites by conversion of minerals is not really a commonly used process. In several papers which deal with the synthesis of zeolite A, X, and NaY from minerals, kaolin or metakaolin is used as aluminum source [45–47]. A disadvantage of such procedures is the presence of impurities in the applied minerals [45], but some advantages (simple treatment of the mother liquor and a nearly waste-free production) support the application of that synthesis method especially in the case of zeolite NaY [46].
\nThe properties of zeolite molecular sieves can be influenced by the properties of the starting zeolite powder. For instance, the hydrothermal stability or desorption characteristics of FAU vary with the chemical composition, especially the aluminum content [48]. The particle size, particle size distribution, and the surface characteristics of single zeolite crystals affect the adsorption properties as well as the mechanical stability of zeolite molecular sieves. By varying the synthesis gel composition, time, or temperature or by adding additives to the synthesis gel, the mentioned properties of the zeolite powder can be changed [49, 50]. Depending on the intended applications, the particle size distribution is adjusted. Besides the described classical gel synthesis [51] resulting in particles of about 5 µm, microparticles (particle size of approx. 1 µm) and nanoparticles (particle sizes between 50 and 100 nm) can be achieved via new synthesis routes [52].
\nIn dynamic adsorption processes, where the adsorbent has to be regenerated frequently, the fluid dynamics (e.g., the pressure drop over the fixed bed of molecular sieves) has to be taken into account. Therefore, the zeolite has to be applied in a suitable particle size (usually in the form of shaped mechanically stable macroscopic particles such as beads/spheres or extrudates/cylinders).
\nBecause pure zeolite powder does not exhibit binding properties, an appropriate binder needs to be applied to form the above-mentioned macroscopic particles. Figure 2 shows the main principles for the manufacturing of conventional binder-containing zeolite molecular sieves (bulk material).
\n\nThe zeolite component is the main component of the pre-mixture and can be applied as dried zeolite powder (occasionally as filtercake). Usually, the zeolite component is modified (as described above, e.g., ion exchanged or dealuminated) prior to the shaping step. Besides the zeolite component a binder material is put into the pre-mixture. Mineral binders such as bentonite, attapulgite, or kaolin are common [53, 54] as well as synthetic binders such as alumina, silica [54, 55], or a mixture thereof [56]. The type of binder material to be applied depends on the shaping procedure and on the final application of the zeolite molecular sieve. Bentonite (montmorillonite) for example is commonly used for extrusion [57, 58], attapulgite for beading [59]. It should be noted that (natural) mineral binders may contain impurities (e.g., catalytically active heavy metals), which could cause undesired side reactions in the final application. If necessary, additives such as shaping aids (e.g., mineral oil, PVA, starch derivate solutions [60]) are put into the pre-mixture to make the shaping process most effective. Such mainly organic compounds are burnt out in subsequent thermal treatment steps. In order to create a defined secondary pore system (see below) thermally or chemically, removable spacers (e.g., cellulose fibers or soluble salts) are added to the pre-mixture. In most of the bulk zeolite molecular sieves, a binder content of around 20% (anhydrous basis) is used. But also lower (down to around 5%) and higher (above 30%) binder amounts are described [59].
\nScheme of the principle manufacturing procedures for binder-containing zeolite molecular sieve shapes (bulk material).
After the (mainly dry) mixing of all aforementioned materials in the pre-mixture usually a certain amount of water is added in order to adjust the viscosity and plasticity of the mixture for the related shaping process that can be agglomeration granulation [59], spray granulation [61], or extrusion [62]. After the shaping process, the molecular sieve has to be dried and activated in a thermal step, for example, in a rotary kiln [63] or belt calciner [64] to remove the water and other adsorbed compounds. The applied temperature is often higher than required for the zeolite activation, since the binder system needs such higher temperatures for setting. The zeolite component in zeolite NaX beads with attapulgite as binder materials, for example, needs not more than 350–400°C for a complete activation (residual water content <1 wt% measured by Karl-Fischer titration) [65]. But the attapulgite binder needs approximately 500 °C for getting converted into a mechanically stable structure [53, 59]—a temperature which can already be critical for the structural stability of the zeolite [66, 95]. Due to the limited hydrothermal stability [67–69, 95] of hydrophilic zeolites, the activation step has to be carried out carefully. To avoid (partial) zeolite destruction during the activation step, the released water needs to be removed from the shape as fast as possible in order to avoid the appearance of hydrothermal conditions. The higher the temperature and higher the moisture concentration directly at the zeolite centers the higher the probability for (partial) zeolite destruction [70]. By applying a controlled temperature increase, a low height of the granules bed and/or a dry purge gas can be met these conditions. Depending on the particular conditions, a residual water content of less than one percent can be reached. During the cooling step as well as during the storage of the activated material, the presence of humidity or other adsorptive components should be avoided to prevent undesired adsorption on the material. Therefore, activated zeolite molecular sieves are usually packed in hermetically sealed packaging units, as, for example, sealed steel drums or big bags equipped with sealed inliners.
\nThe mentioned use of a binder system opens a large variety of zeolite molecular sieves with different properties. Depending on the final application, the properties of the single shapes or the bulk material have to be optimized. For instance, with regard to the particle size, two limits should be considered: The bigger the single shape, the higher the probability for a possible limitation of the mass transfer within the shape. That means the diffusion within the single shape might be so slow that the active adsorptive matter is not completely used if the full adsorption/desorption cycle is very fast (e.g., in (vacuum) pressure swing processes [71]) [72]. But the smaller the single shapes, the larger the pressure drop over the fixed bed and the higher the risk of fluidization. Therefore, the adjustment of the size of the shapes is a critical parameter in the design of an adsorption process. Besides the size also other characteristics of the bulk material are to be adjusted such as mechanical properties such as dust formation caused by attrition/abrasion between shapes or the shapes and the wall of the adsorber vessel. Because dust may cause problems in a running adsorption process (e.g., blocking of valves), the dust formation has to be avoided by applying an optimal type and amount of binder as well as by generating single shapes with as smooth as possible surfaces. To receive smooth surfaces on single shapes of bulk material, the shaping process has to be run accurately. So, for example, in the case of extruded material an optimal plasticity of the extrusion mixture (pre-mixture), and in the case of agglomeration granulation, a post-granulation surface polishing step may help avoid/lower attrition/dust formation. Besides dusting, the mechanical stability (crush resistance) of the shapes has to be considered. The higher the bulk bed in the adsorber the bigger the weight and force that affects the lowest single shapes in the bed, which could finally result in a destruction of the shapes, and hence, generation of fines and an increased pressure drop. The binding mechanism of activated binder-containing zeolite molecular sieves is based on the generation of a network of binder material, wherein the zeolite crystals are embedded. Figure 2 shows SEM pictures of the raw materials. The zeolite crystal agglomerates (top left) and the binder (top right) form a physically strong bound shape, which is demonstrated in Figure 2 downright. As mentioned earlier, the use of (adsorption inert) binder material reduces the adsorption capacity zeolite molecular sieves by approximately the percentage of binder in the shape (see Table 1).
\n\n | \nZeolite NaX powder | \nBinder-containing zeolite NaX beads | \n
---|---|---|
Water adsorption capacity at 55% relative humidity, 25°C/wt% | \n31.5 | \n26.5 | \n
N2 adsorption capacity at 1000 mbar, 25°C/cc(STP)/g | \n10.7 | \n8.0 | \n
CO2 adsorption capacity at 333 mbar, 25°C/cc(STP)/g | \n120.7 | \n95.4 | \n
Adsorption capacities for zeolite NaX (pure zeolite NaX powder and binder-containing bulk material with 82.5 wt% zeolite NaX and 17.5 wt% attapulgite).
Hg intrusion curves of binder-containing zeolite NaX bulk material with 17.5 and 10.0 wt% of attapulgite binder.
In addition to the mechanical properties, the type and amount of binder (and the shaping process applied) have an essential influence on the structure of the secondary pore system of the shape—the part of the shape through which the transport of the molecules to and from the zeolites crystals within the shape is realized [66, 73]. Said secondary (or transport) pore system strongly influences the kinetics of the adsorbent, and hence, the adsorption process. So the zeolite NaX beads mentioned in \nTable 1\n show an attrition of <0.1 wt% (determined using Chemiewerk Bad Köstritz GmbH method) but relatively tight transport pores, which can lead to a slower diffusion within the zeolite beads. Using a lower amount of binder material, the adsorption capacity increases and the transport pores become slightly wider; see Figure 3. A faster diffusion is possible. But using a lower amount of binder material leads to an increased attrition value (0.2 wt%, determined using Chemiewerk Bad Köstritz GmbH method); for some applications that might be a high risk for an operating plant.
\n\nTo avoid the above-mentioned disadvantages of binder-containing zeolite molecular sieve bulk materials such as adsorption capacity reduction by adsorption inert binders or influence of the secondary pore structure by the binder material, the so-called binderless zeolite molecular sieves were developed. There are different manufacturing procedures for binderless molecular sieves described in the open or patent literature. In most of those processes, the same shaping principles as mentioned earlier for the manufacturing of binder-containing zeolite molecular sieve are applied. They differ in the raw materials, respectively, the composition—especially the type and amount of the so-called temporary binder—of the starting pre-mixture, or the conditions for the conversion of the temporary binder into zeolite matter. Important for the generation of binderless zeolite molecular sieve is that the temporary binder contains only those elements, which are present in the target zeolite matter; that means in most of the cases silicon, aluminum, and sodium, for example, for binderless molecular sieves of A, NaX, and NaY type (or mixtures thereof). Only for the preparation of binderless zeolite LSX-type molecular sieves, potassium-containing systems are used [74].
\nThus, it is possible to generate binderless zeolite shapes using temporary binder material such as kaolin as starting material [75]. A mixture of temporary binder material such as kaolin, metakaolin or silica, and zeolite powder or zeolite filter cake is also mentioned [76–83]. The conversion step can be a wet chemical [75, 79] or an at least partially autogenic thermal reaction [84].
\nScheme of the principle manufacturing procedure of binderless zeolite molecular sieve shapes (bulk material).
\nFigure 4 shows the principle manufacturing procedure starting with shaping a pre-mixture using the above-mentioned technologies agglomeration granulation, spray granulation, or extrusion. Taggart [75] reported about shaping a mixture of kaolin and sodium hydroxide followed by drying of the shapes. It should be considered that kaolin has good binding properties but nearly no chemical reactivity. Due to that fact, the kaolin needs to be converted thermally (about 600 °C) into the chemically more reactive metakaolin. Depending on the target zeolite type, a suitable reaction solution comprising of sodium, aluminum, and/or silicon components is prepared. Usually, the shapes are aged and further processed in that reaction solution to convert the temporary binder into the desired zeolite matter. Finally, the shapes are washed, dried, and activated. Taggart mentioned that, due to the limited accessibility of the interior of the shapes by the mentioned reaction solution (blocked or too tight secondary pore system), the degree of the conversion of the temporary binder into zeolite matter, and hence, the adsorption capacity of the resulting material is limited, and can be enhanced if zeolite powder is used in the starting mixture. However, the mechanical stability of the resulting shapes is lower. Therefore, Howell et al. [85] propose the utilization of pore-forming agents (spacers), which are burned out in the following thermal treatment, thereby leaving space for the better accessibility of the interior of the shapes. Goytisolo et al. [76], Barrer et al. [77], Nozemack et al. [78], Brandt et al. [79], and Schumann et al. [80] described the manufacturing of binderless zeolite molecular sieves using a mixture of metakaolin, zeolite powder of such zeolite type, in which the metakaolin should be converted into, and additional sodium and silicon compounds such as sodium hydroxide, silicic acid or sodium silicate as feed for the shaping process. The zeolite powder in the mixture has obviously crystallization triggering properties and supports the generation of an open, for the reaction solution accessible pore system. It has to be considered that metakaolin has practically no binding properties. Thus, one has to make sure, that the process is carried out in a way, that the shapes, which are coming out of the shaping process, are mechanically stable enough until the conversion of the non-zeolitic compounds into zeolite matter in the reaction solution is completed. Said conversion is the basis for the mechanical stability of binderless molecular sieve shapes (see below). If it is possible to put all necessary compounds into the starting mixture for the shaping the reaction solution can be water [77, 78], otherwise all missing components for the desired zeolite formation have to be present in the reaction solution [75, 79, 80]. Another way to manufacture binderless zeolite molecular sieves is the use of silica as synthetic temporary binder. The shapes obtained are aged to achieve a certain water stability [81] followed by the conversion of the temporary binder in a solution consisting of aluminum and sodium components [82, 83].
\n\nThe wet chemical reaction for the conversion of the temporary binder is preferably carried out by recirculating the reaction solution over the bulk material at suitable temperatures without moving the single shapes in order to avoid attrition between the still relatively soft shapes.
\nIn the course of the chemical conversion of the non-zeolitic components into zeolite matter, the binding mechanism changes. In the case of kaolin/metakaolin-based systems, the mechanical stability of the shapes is now based on intergrowths between zeolite crystals in the single shape (see Figure 4 bottom). Said intergrowths are formed during the conversion of the metakaolin into a polycrystalline zeolite matter [86]. Such unusual crystallization behavior can be explained by considering the available space for crystallization in a shape. On the outer surface of a single shape, there is enough space for a conventional and epitaxial crystal growth (see Figure 4 down left for zeolite NaX), whereas in the interior, the space is obviously limited in a way that typical zeolite crystals such as octahedrons or cubes with rounded corners cannot be formed, but polycrystalline structures consisting of zeolite in untypical shape only (see Figure 4 bottom right for zeolite NaX) [86]. After the chemical conversion, the bulk material is separated from the mother liquor (which can reused for further reactions) and washed until a desired pH or conductivity of the effluent is achieved. Optionally, an ion exchange (applying a suitable ion exchange solution) can be affiliated. Finally, the material is dried and thermally activated in a suitable device (e.g., rotary kiln or belt calciner). As the mechanical stability of binderless molecular sieve shapes is already achieved during the temporary binder conversion step said thermal treatment is just needed to activate the zeolite, and not anymore to set a binder component. Thus, usually lower temperatures can be applied, which saves costs and is more gentle to the thermally sensitive zeolite structure. Despite the different manufacturing procedures of binder-containing and binderless zeolite bulk material, the mechanical stability of the resulting shapes is similar. In the case products produced according to [79] and [80], a higher mechanical strength for bigger binderless zeolite spheres in comparison with binder-containing zeolite spheres of the same size and zeolite type is observed. Using comparable analytical methods for both kinds of zeolite bulk material, the attrition/dust formation is also similar.
\nAs can be shown exemplary in Table 2, the static adsorption capacity of binderless zeolite NaX bulk material is similar to that of pure zeolite NaX powder. That indicates that the binderless zeolite bulk material consists of nearly 100% of zeolite matter.
\n\n | \nZeolite NaX powder | \nBinder-containing zeolite NaX beads | \nBinderless zeolite NaX beads | \n
---|---|---|---|
Water adsorption capacity at 55% relative humidity, 25°C/wt% | \n31.5 | \n26.5 | \n31.2 | \n
N2 adsorption capacity at 1000 mbar, 25°C/cc(STP)/g | \n10.7 | \n8.0 | \n10.5 | \n
CO2 adsorption capacity at 333 mbar, 25°C/cc(STP)/g | \n120.7 | \n95.4 | \n119.4 | \n
Adsorption capacities for zeolite NaX (pure zeolite NaX powder, binder-containing bulk material with
82.5 wt% zeolite NaX and 17.5 wt% attapulgite and binderless zeolite NaX bulk material).
A further interesting observance is, that in the above-described special manufacturing process for binderless molecular sieves, a very open secondary pore system is generated, which allows faster kinetics as compared to conventional binder-containing zeolite molecular sieves with the (usual) binder content of around 20% [86], Figure 5 proves the presence of a larger amount of macro pores. While the ratio of meso-pore to the sum of meso- and macro-pores is 30% for conventional binder-containing zeolite molecular sieves (pre-mixture consisting only of zeolite and attapulgite) the same ratio is only 5% for binder-less zeolite molecular sieves (produced according to [80]) [66].
\nHg intrusion curves of binder-containing and binderless zeolite NaY bulk material.
Due to the mentioned open secondary pore system, the above-mentioned problems concerning the inner shape transport limitations in binder-containing shapes depending on the size are eased in the case of binderless shapes.
\nIt should, however, besides all obvious advantages of binderless over binder-containing molecular sieves mentioned earlier, noted, that, at least in the case of the kaolin/metakaolin-based systems, the structure of the binderless shapes is more rigid (less flexible) than the one of related binder-containing shapes. This can easily be explained by the different binding mechanisms: intergrowths in the case of the binderless structures, embedment in the case of binder-containing structures. This is a fact which must not be underestimated and needs to be taken into consideration especially in applications, which are connected with structural compressions/expansions (e.g., as a result of fast heat release and/or lattice changes by adsorption/desorption).
\nIn order to improve the overall effectivity of a given adsorption process, the increase of the volume-related adsorption capacity of the adsorbent used is often desirable. Said volume-related adsorption capacity is depending on the (bulk) density of the bulk material and on the amount of adsorption active matter within the shape (binder-containing or binderless zeolite bulk material). The bulk density itself depends on the density of the single shape(s) and on the void space between the shapes. It is known, that, for example, the packing density of a close-packing of spheres of equal diameter is ca. 74%; thus, the void space is about 26%. Theoretically, an increase of the packing density (and thus, of the bulk density) can be achieved by mixing spheres of optimal adjusted sizes, but it is certainly very difficult and expensive to produce and arrange such bed consisting of spheres of optimal sizes, the more, as the influence of the packing density on the pressure drop has always to be considered. An alternative to dense packed bulk beds can be compact zeolite bodies such as multi-channel tubes or honeycombs. By choosing appropriate geometries of such compact zeolite bodies with optimal channel dimensions a space filling (packing density) of much more, the mentioned 74% (theoretically up to 100% in the case of a void free compact body) is possible. In addition, such compact bodies can be modified in many ways to meet the requirements of the related adsorption process. Thus, a gas flow can be guided straight through the parallel arranged channels of a honeycomb-like structure, but through alternately blocking of the channels, a compulsorily perfusion is also possible [35].
\nMost of the manufacturing procedures of such compact zeolite bodies described in the literature are based on the use of (adsorption inert) binder material. As in the above-mentioned cases of binder-containing zeolite bulk material, synthetic binder [87] and mineral binder materials [88] are applied in the case of compact shapes as well. Consequently, the same disadvantageously impacts on the properties of the related adsorbents need to be considered: The introduction of the mentioned binder material causes a dilution of the adsorptive active matter and consequentially a reduction of adsorption capacities, and the binder material could affect the desired adsorption and desorption processes by forming a disadvantageous secondary pore system [66], an effect which at least partly can be cured by applying thermally removable pore-forming substances [89], and the fact, that impurities present in mineral binders may support undesired chemical side reactions.
\nAt that point, it seems to be worth to remember, what was discussed above in this regard—to overcome the disadvantages of binder-containing molecular sieves bulk material. The solution (at least to a certain extent) was the application of binderless systems. And recently it could clearly be demonstrated that the same principle concept works in the case of zeolite-containing compact bodies as well: A high volume-related adsorption capacity can be reached [35]. The related honeycombs, multi-channel tubes, cylinder, etc. exhibit a remarkable adjustable high space filling (up to 100%), but at the same time a similar open secondary pore system such as mentioned earlier for binderless zeolite bulk material [90, 35].
\nFor both types of compact zeolite bodies (binder-containing and binderless structures), the production process starts with mixing the ingredients zeolite powder, (temporary) binder, water and if needed shaping aids (such as e.g., glycerol or cellulose derivates) or in case of binder-containing compact bodies pore-forming substances if necessary (see Figure 1). Shaping technologies can be extrusion, pressing, or molding—depending on the desired geometry of the compact zeolite body. It should be noted that in the case of the binderless systems, the application of kaolin instead of metakaolin as main non-zeolitic component has been shown as being advantageous. In case of the binder-containing compact zeolite bodies, the following and final manufacturing step is the thermal treatment for drying and activation, where the organic compounds are burned out as well as the all water and other adsorbed compounds present in the system is removed and the binder is set. In case of binderless compact zeolite bodies, a first thermal treatment is needed for removing the organic shaping aids and converting kaolin into metakaolin [35, 91]. The generated metakaolin is converted into zeolite during a following wet chemical reaction. The related reaction solution consists of all ingredients necessary for the conversion of the metakaolin into the desired zeolite type (A, X or NaY) similar to the manufacturing of binderless zeolite bulk material. The conversion can be followed by further modification processes, for example, ion exchange. The completeness of the conversion of the non-zeolitic into zeolite matter can be demonstrated, for example, by adsorption measurements (in combination with XRD [35]). The static water adsorption capacity for zeolite 4A honeycombs in comparison with the fully crystalline zeolite 4A powder is shown in \nTable 3\n proving that the honeycomb consists of nearly 100% zeolite 4A matter.
\n\n | \nZeolite 4A powder | \nBinderless zeolite 4A honeycomb | \n
---|---|---|
Water adsorption capacity at 55% relative humidity, 25°C/wt% | \n24.8 | \n24.7 | \n
Adsorption capacities for zeolite 4A (pure zeolite 4A powder and binderless zeolite 4A honeycomb).
Just for completion it should be noted that compact zeolite-containing bodies can also be manufactured by washcoating [92, 93], where mainly for catalytic applications, the catalytically active zeolite component is deposited onto monolithic support structures, as, for example, ceramic (in most cases cordierite) honeycombs by washcoating. The result is a compact body with a thin zeolite layer. Furthermore, the crystallization of zeolite matter directly on aluminum foams is published [94]. Such structures exhibit interesting flow characteristics, but due to the rather large void fraction and a relatively thin zeolite layer onto the aluminum support, a low volume-related zeolite amount, and hence, a low volume-related adsorption capacity is observed.
\nZeolite molecular sieves play an important role as highly effective adsorbents in major industrial adsorption processes. The properties of such molecular sieves can be tailored according to the requirements of the related applications. Besides the common binder-containing molecular sieves, binderless grades are applied. Due to the particular binding mechanism and the related special secondary pore system, binderless molecular sieves are mainly applied where fast kinetics is required, thus, especially in (vacuum) pressure swing adsorption processes. Furthermore, the principle concept for the manufacturing of binderless zeolite bulk material can be applied to the manufacturing of compact zeolite bodies, too. This opens ways for a further improvement of the related adsorption processes.
\nThe authors gratefully acknowledge Gundula Fischer, Hannes Richter, and Andreas Häusler from Fraunhofer IKTS Hermsdorf, Germany for the contribution to this work.
\nRecently, artificial night lighting occurs commonly in many urban areas and can be light pollution that influences negatively in many ways, i.e., waste the energy for the pollution production, causing sky glow, creating light trespass, and building glare [1] including causes of ecological effects on many organisms [2, 3, 4, 5, 6]. The night lighting changed unnaturally the innate behaviors of the organisms by reducing foraging behavior, predatory behavior, metabolism, growth rate, and reducing population numbers finally. Additionally, many species of insects were unavoidably trapped by phototaxis ability [4, 7, 8] including fireflies. Unfortunately, the fireflies’ bioluminescent courtship signals were likely interfered [4].
\nThe effect of artificial light on fireflies was studied in many firefly species. Under the light pollution, the abundance of fireflies displayed lower numbers than without lighting [4, 9]. Several firefly researchers have considerably examined how the light pollution impacts on the bioluminescent insects especially their courtship and reproduction. The flooding of light altered mate location behavior of
Camera illumination or flash photography is another type of man-made light that is commonly used. Although the cameras do not produce long steady light, the blight flashlight probably influences animal behaviors. The effects of flash photography on organisms have been little studied. The flash testing on seahorse behaviors underwater was done and showed no significant long-term consequences [13]. The nocturnal insects such as fireflies have never been investigated.
\nCongregation of male
In the present study, we examined the effects of camera illumination on flashing behavior of male and female
Comparison of the sympatric firefly species,
Two hundred adults of
Because of the congregation behavior of
Four treatments of different light sources of camera illumination were set up in laboratory: (1) a white flash from smartphone camera (SC), Samsung Galaxy Note 3; (2) a white flash from digital camera (DC), SLR Olympus TG 4; (3) red light for autofocus assist before a white flash from digital camera (RDC), Sony Exmor R; and (4) no flash (control). These treatments were selected from the representative flash characters found in firefly photography.
\nThe apparatus of the experiment were designed as in Figure 2. The distance between the illumination point and the tested fireflies was 2 meters that is the possible distance in the real photography situation of tourists. The firefly flashing behavior was videographed using Sony Handycam™ digital camera recorder (HDR-SR11E) for 20 min in each replication (10 replications per treatment).
\nExperimental apparatus.
In the real cases of firefly photography by tourists, the fireflies would face with sequences of camera illumination; the tested fireflies were experimentally exposed to 3-time flashing to examine a consequence of sequential flashing. The flashes were shot after 5 min in the beginning of the experiment and were shot 3 times with 5-min intervals. The fireflies were continually observed and allowed to lay eggs after finishing the experiment. The adult lifespan and number of the eggs were recorded. The fireflies were tested within four nights after collection to avoid the errors from weakness and aged adults.
\nThe one of four males in each experimental set were randomly selected to analyze flash patterns. The video files were converted to Audio Video Interleave or .AVI format file to analyze by using time-lapse image analysis (TiLIA), a free software package for signal and flight pattern analyses of fireflies (available at Google Drive: https://drive.google.com/open?id=0B2o7FRVs2VohMmx2QzBVX3ZDeDA) [19]. Each video frame was converted to Tagged Image File Format (.TIFF) at each 0.03 sec. The light organs of all fireflies were defined as area of interest (ROIs) to measure the light intensities. The outputs (time and light intensities) were exported to Microsoft Excel® for flash parameter calculation applied from reference [20] (Table 1).
\nFlash parameters | \nExplanation | \n
---|---|
Pulse duration | \nDuration between the beginning flash to the end of the flash (light period) | \n
Interpulse duration | \nDuration between two pulse durations (dark period) | \n
Flash interval | \nSummarizing of pulse and interpulse durations | \n
Flash rate | \nNumber of flash per time | \n
Terminology of flash signals.
The flashes during courtship time or during synchronous flashing of the tested males were selected for flash parameter analysis by counting numbers of frames occurred in each flash parameter—pulse duration, interpulse duration, and flash interval—and then converted to second time unit.
\nThirty flashes of males in each treatment were statistically analyzed. The comparison of three types of flash parameters among camera illumination treatments and among different time sequences was statistically analyzed using one-way ANOVA and Tukey multiple comparison test. The flash rate of smartphone treatments was compared with control group by using independent t-test. A value of p < 0.05 was considered statistically significant. All statistical analyses were performed using SPSS program version 24.
\nA thousand and 33 flashes from 30 males in the control group were analyzed for flash parameters of
Flash parameters | \nMean ± SE | \n
---|---|
Pulse duration | \n0.10 ± 0.02 | \n
Interpulse duration | \n0.41 ± 0.01 | \n
Flash interval | \n0.51 ± 0.01 | \n
Flash rate (per sec) | \n1.97 ± 0.03 | \n
Flash parameters of
The flashing behavior of
Comparison of flash parameters (±SE) of
The results of the study showed that camera flashes affect temporarily the flashing behavior of
After applying each types of flash photography treatment 3 times, all flash parameters in different time series were analyzed and compared in each flash type. The DC and RDC treatments displayed fluctuation of pulse duration but did not quite differently before shooting flash (Figure 4a). On the other hand, SC displayed an increasing trend of pulse duration (
Comparison of flash parameters (±SE), pulse duration (a), interpulse duration (b) and flash interval (c) of
The flash series did not affect interpulse duration and flash interval of DC, although they could cause a small fluctuation in RDC. Alternatively, SC increased interpulse duration and flash interval after receiving the first flash (
The female flashes are not likely the answer response to the male flashes. They glowed irregularly. Although we could not examine the effect of the camera flashes on the female receptivity definitely, the female flashes were also recorded. The illumination from the smartphone caused stopped female flashes with the highest percentage (40%) followed by RDC (20%), while the females in control and DC treatment displayed normal flashing behavior. The observation of oviposition behavior after the shooting flash experiment showed that females from all treatments could lay eggs. Although the females might mate with other males before testing, they can express egg oviposition behavior after receiving flash effect. The fireflies in all flash type experiments can lay eggs for 40–50% with the maximum numbers of eggs, 40–67.
\nThe experiment of testing camera illumination was carried out using adult
These results indicated that the firefly could adapt their flashing behavior when any strong interferences are encountered. The behavioral plasticity in flashing communication of fireflies was discussed for a long time. Although the flash codes are species specificity, fireflies can change their flash codes depending on the situation and environmental conditions [12, 24]. The plastic behavior might benefit males by increasing their advertisement to females over artificial lighting interference.
In the experiment, the tested females did not respond specific flash signals to the males that might cause from mated status of the females or captive condition. Reference [2] reported that the captive
The camera illuminations produced white light that are a broad spectrum composed of both short and long wavelengths of light. In this study, the response of male fireflies was quite similar to the effect of short wavelength light studied by the researchers [12]. The main biological effect of the light might come from the short wavelength light. All experimental light types were mainly LED flash technology varied with light intensities and function system. The detail of light spectrum was not described. The smartphone illumination was the brightest type that showed the strongest effect when compared with DC and RDC. The fireflies received SC flashes and showed twice the time duration of flash interval than control.
\nCurrently, smartphone photography has become commonly used. The smartphone flashes are considerably developed to improve night shot photographs such as dual flash and Xenon flash that are stronger than LED and might cause adverse impact on the firefly behavior. The peak wavelength of LED and xenon flashes is in the blue region of visible light (400–480 nm) that could adverse biological effects including human eyes and skin when receiving long exposure [25]. The toxic effects of short wavelength light on many insects are known, i.e., mortality in immature stages of
Timing of receiving flashes is probably an important factor. The tested fireflies were exposed to the camera illumination in the beginning of mating sequences. The 80% of experimental treatment could observe paired fireflies after shooting flashes. It is also possible that the copulation could not continually happen if they are interrupted during the sensitive steps of their mating sequences, i.e., dorsal mouthing. The females might remain for a long time in dorsal mouthing posture as in mating under light pollution of
The courtship behavior of
To conclude, any types of the camera illumination influenced
Studies on the effect of artificial night lighting on fireflies have been demonstrated for concerning the effects on firefly populations and their conservation for a decade. However, they have still little understood in particular species and some different types of lights.
\nThe book chapter has presented the impact of artificial light focusing on flash photography from both cameras and smartphones that probably have an impact on
We thank Sudarat Meephop for assistance in data collection and Dr. Parichart Laksanawimol who helped with the experimental design. This study was supported by Kasetsart University and Bangchak Corporation Public Company Limited.
\nThe author declares no conflict of interest.
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In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.",book:{id:"6963",slug:"immune-response-activation-and-immunomodulation",title:"Immune Response Activation and Immunomodulation",fullTitle:"Immune Response Activation and Immunomodulation"},signatures:"José Luis Muñoz-Carrillo, Juan Francisco Contreras-Cordero,\nOscar Gutiérrez-Coronado, Paola Trinidad Villalobos-Gutiérrez,\nLuis Guillermo Ramos-Gracia and Viridiana Elizabeth Hernández-Reyes",authors:[{id:"214236",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Muñoz-Carrillo",slug:"jose-luis-munoz-carrillo",fullName:"Jose Luis Muñoz-Carrillo"},{id:"216081",title:"Dr.",name:"Oscar",middleName:null,surname:"Gutiérrez-Coronado",slug:"oscar-gutierrez-coronado",fullName:"Oscar Gutiérrez-Coronado"},{id:"220717",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Contreras Cordero",slug:"juan-francisco-contreras-cordero",fullName:"Juan Francisco Contreras Cordero"},{id:"233193",title:"Dr.",name:"Paola Trinidad",middleName:null,surname:"Villalobos-Gutiérrez",slug:"paola-trinidad-villalobos-gutierrez",fullName:"Paola Trinidad Villalobos-Gutiérrez"},{id:"254015",title:"Dr.",name:"Viridiana Elizabeth",middleName:null,surname:"Hernández-Reyes",slug:"viridiana-elizabeth-hernandez-reyes",fullName:"Viridiana Elizabeth Hernández-Reyes"},{id:"257472",title:"Dr.",name:"Luis Guillermo",middleName:null,surname:"Ramos-Gracia",slug:"luis-guillermo-ramos-gracia",fullName:"Luis Guillermo Ramos-Gracia"}]},{id:"33741",doi:"10.5772/36947",title:"Fundamentals and Applications of Immunosensors",slug:"fundamentals-and-applications-of-immunosensors",totalDownloads:5014,totalCrossrefCites:15,totalDimensionsCites:34,abstract:null,book:{id:"1499",slug:"advances-in-immunoassay-technology",title:"Advances in Immunoassay Technology",fullTitle:"Advances in Immunoassay Technology"},signatures:"Carlos Moina and Gabriel Ybarra",authors:[{id:"110541",title:"Dr.",name:"Carlos",middleName:null,surname:"Moina",slug:"carlos-moina",fullName:"Carlos Moina"},{id:"110556",title:"Dr.",name:"Gabriel",middleName:null,surname:"Ybarra",slug:"gabriel-ybarra",fullName:"Gabriel Ybarra"}]},{id:"53240",doi:"10.5772/66380",title:"Staphylococcus aureus Biofilms and their Impact on the Medical Field",slug:"staphylococcus-aureus-biofilms-and-their-impact-on-the-medical-field",totalDownloads:3774,totalCrossrefCites:18,totalDimensionsCites:34,abstract:"Despite the discovery of antibiotics, the battle against bacteria is so far in their favor, specifically because bugs are able to develop a superstructure named biofilm, to resist and to survive in the environment. Nosocomial infections, a major health problem, are due at 80% to biofilm‐associated infection, and Staphylococcus aureus is the leading bacteria species in this domain. Moreover, the antimicrobial resistance of this bacterial community is accentuated when it is formed by superbugs such as methicillin‐resistant S. aureus (MRSA). In this chapter, the mechanism and the physiology of S. aureus biofilm as well as their consequences in the clinical domains are described. To complete the vision on S. aureus biofilms, some “anti‐biofilm” strategies will be highlighted.",book:{id:"6045",slug:"the-rise-of-virulence-and-antibiotic-resistance-in-staphylococcus-aureus",title:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus",fullTitle:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus"},signatures:"Fany Reffuveille, Jérôme Josse, Quentin Vallé, Céline Mongaret and\nSophie C. Gangloff",authors:[{id:"54351",title:"Prof.",name:"Sophie C.",middleName:null,surname:"Gangloff",slug:"sophie-c.-gangloff",fullName:"Sophie C. Gangloff"},{id:"190356",title:"Ph.D.",name:"Fany",middleName:null,surname:"Reffuveille",slug:"fany-reffuveille",fullName:"Fany Reffuveille"},{id:"191408",title:"Dr.",name:"Jérome",middleName:null,surname:"Josse",slug:"jerome-josse",fullName:"Jérome Josse"},{id:"203850",title:"Dr.",name:"Quentin",middleName:null,surname:"Vallé",slug:"quentin-valle",fullName:"Quentin Vallé"},{id:"203852",title:"Dr.",name:"Céline",middleName:null,surname:"Mongaret",slug:"celine-mongaret",fullName:"Céline Mongaret"}]},{id:"68185",doi:"10.5772/intechopen.88013",title:"Macrophages: The Potent Immunoregulatory Innate Immune Cells",slug:"macrophages-the-potent-immunoregulatory-innate-immune-cells",totalDownloads:2166,totalCrossrefCites:16,totalDimensionsCites:30,abstract:"Macrophages are ubiquitously present innate immune cells in humans and animals belonging to both invertebrates and vertebrates. These cells were first recognized by Elia Metchnikoff in 1882 in the larvae of starfish upon insertion of thorns of tangerine tree and later in Daphnia magna or common water flea infected with fungal spores as cells responsible for the process of phagocytosis of foreign particles. Elia Metchnikoff received the Noble prize (Physiology and Medicine) for his discovery and describing the process of phagocytosis in 1908. More than 130 years have passed and different subtypes and roles of macrophages as innate immune cells have been established by the researchers. In addition to their immunoregulatory role in immune homeostasis and pathogenic infection, they also play a crucial role in the pathogenesis of sterile inflammatory conditions including autoimmunity, obesity, and cancer. The present chapter describes the immunoregulatory role of macrophages in the homeostasis and inflammatory diseases varying from autoimmunity to metabolic diseases including obesity.",book:{id:"8590",slug:"macrophage-activation-biology-and-disease",title:"Macrophage Activation",fullTitle:"Macrophage Activation - Biology and Disease"},signatures:"Vijay Kumar",authors:[{id:"63844",title:"Dr.",name:"Vijay",middleName:null,surname:"Kumar",slug:"vijay-kumar",fullName:"Vijay Kumar"}]}],mostDownloadedChaptersLast30Days:[{id:"56849",title:"Physiology and Pathology of Innate Immune Response Against Pathogens",slug:"physiology-and-pathology-of-innate-immune-response-against-pathogens",totalDownloads:6086,totalCrossrefCites:20,totalDimensionsCites:26,abstract:"Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response and an antigen-specific adaptive immune response. The innate response is characterized by being the first line of defense that occurs rapidly in which leukocytes such as neutrophils, monocytes, macrophages, eosinophils, mast cells, dendritic cells, etc., are involved. These cells recognize the pathogen-associated molecular patterns (PAMPs), which have been evolutionarily conserved by the diversity of microorganisms that infect humans. Recognition of these pathogen-associated molecular patterns occurs through pattern recognition receptors such as Toll-like receptors and some other intracellular receptors such as nucleotide oligomerization domain (NOD), with the aim of amplifying the inflammation and activating the adaptive cellular immune response, through the antigenic presentation. In the present chapter, we will review the importance of the main components involved in the innate immune response, such as different cell types, inflammatory response, soluble immune mediators and effector mechanisms exerted by the immune response against bacteria, viruses, fungi, and parasites; all with the purpose of eliminating them and eradicating the infection of the host.",book:{id:"5975",slug:"physiology-and-pathology-of-immunology",title:"Physiology and Pathology of Immunology",fullTitle:"Physiology and Pathology of Immunology"},signatures:"José Luis Muñoz Carrillo, Flor Pamela Castro García, Oscar\nGutiérrez Coronado, María Alejandra Moreno García and Juan\nFrancisco Contreras Cordero",authors:[{id:"214236",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Muñoz-Carrillo",slug:"jose-luis-munoz-carrillo",fullName:"Jose Luis Muñoz-Carrillo"},{id:"216080",title:"Dr.",name:"Alejandra",middleName:null,surname:"Moreno-García",slug:"alejandra-moreno-garcia",fullName:"Alejandra Moreno-García"},{id:"216081",title:"Dr.",name:"Oscar",middleName:null,surname:"Gutiérrez-Coronado",slug:"oscar-gutierrez-coronado",fullName:"Oscar Gutiérrez-Coronado"},{id:"216082",title:"Dr.",name:"Pamela",middleName:null,surname:"Castro-García",slug:"pamela-castro-garcia",fullName:"Pamela Castro-García"},{id:"220717",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Contreras Cordero",slug:"juan-francisco-contreras-cordero",fullName:"Juan Francisco Contreras Cordero"}]},{id:"53922",title:"Phenotypic Markers and Functional Regulators of Myelomonocytic Cells",slug:"phenotypic-markers-and-functional-regulators-of-myelomonocytic-cells",totalDownloads:2243,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"In this chapter, there is a description of hematopoietic stem cells, maturation curve and their differentiation into myeloid cells, including phenotypes and transcription factors involved in this process. Further, we discuss myeloid maturation curve from myeloid precursor, monoblast, premonocyte to monocytes, and also monocytes subsets regarding their CD14 and CD16 expressions and related functions in health and disease. In addition, we reason about the differentiation from monocytes either in dendritic cells or in macrophages in vitro using differential growth factors; these cells are differentiated from those found in vivo being named as monocyte-derived cells. Furthermore, we explore distinguished phenotype of monocytes, macrophages, and dendritic cells monocyte-derived in vitro, using confocal microscopy and flow cytometry, in order to display morphological and phenotypic differences among them.",book:{id:"5484",slug:"biology-of-myelomonocytic-cells",title:"Biology of Myelomonocytic Cells",fullTitle:"Biology of Myelomonocytic Cells"},signatures:"Luciana Cavalheiro Marti, Nydia Strachman Bacal, Laiz Camerão\nBento and Fernanda Agostini Rocha",authors:[{id:"190705",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Marti",slug:"luciana-marti",fullName:"Luciana Marti"},{id:"196049",title:"Dr.",name:"Nydia",middleName:null,surname:"Bacal",slug:"nydia-bacal",fullName:"Nydia Bacal"},{id:"196050",title:"MSc.",name:"Laiz",middleName:null,surname:"Cameirão",slug:"laiz-cameirao",fullName:"Laiz Cameirão"},{id:"196051",title:"Ph.D.",name:"Fernanda",middleName:"Agostini",surname:"Rocha",slug:"fernanda-rocha",fullName:"Fernanda Rocha"}]},{id:"54824",title:"Dendritic Cells: Location, Function, and Clinical Implications",slug:"dendritic-cells-location-function-and-clinical-implications",totalDownloads:4375,totalCrossrefCites:11,totalDimensionsCites:17,abstract:"Dendritic cells (DCs) are antigen-presenting cells derived from bone marrow precursors and form a widely distributed cellular system throughout the body. DCs exert immune-surveillance for exogenous and endogenous antigens and the later activation of naive T lymphocytes giving rise to various immunological responses. Different growth factors and cytokines can modulate the differentiation and function of DCs, GM-CSF, M-CSF, Flt3, and TGF-β, resulting in a large variety of DCs with different functional abilities. Thus, DCs are classified as plasmacytoid DCs (pDCs), conventional DCs (cDCs), and DCs derived from monocytes (mDCs). Functionally, the cDCs may be divided into two states: immature and mature. Immature DCs are specialist in uptaking and processing antigens; in contrast, mature DCs are professional in antigen presentation. It has been observed that immature cDCs can induce immune tolerance while mature cDCs may induce Th2 or Th1 immune responses. It is worth noting that different subpopulations of DCs have the ability to secrete different cytokine patterns, resulting in the induction of different immunological responses. Furthermore DCs are involved in the pathophysiology of several diseases such as contact hypersensitivity, autoimmune diseases, or cancer, but they can also be used as therapeutic tools in these conditions.",book:{id:"5484",slug:"biology-of-myelomonocytic-cells",title:"Biology of Myelomonocytic Cells",fullTitle:"Biology of Myelomonocytic Cells"},signatures:"Andrés Castell-Rodríguez, Gabriela Piñón-Zárate, Miguel Herrera-\nEnríquez, Katia Jarquín-Yáñez and Iliana Medina-Solares",authors:[{id:"190753",title:"Dr.",name:"Andrés",middleName:"Eliú",surname:"Castell-Rodríguez",slug:"andres-castell-rodriguez",fullName:"Andrés Castell-Rodríguez"},{id:"191880",title:"Dr.",name:"Gabriela",middleName:null,surname:"Piñón-Zárate",slug:"gabriela-pinon-zarate",fullName:"Gabriela Piñón-Zárate"},{id:"191881",title:"Dr.",name:"Miguel",middleName:null,surname:"Herrera-Enríquez",slug:"miguel-herrera-enriquez",fullName:"Miguel Herrera-Enríquez"},{id:"191882",title:"Dr.",name:"Katia",middleName:null,surname:"Jarquín-Yáñez",slug:"katia-jarquin-yanez",fullName:"Katia Jarquín-Yáñez"},{id:"204502",title:"BSc.",name:"Iliana",middleName:null,surname:"Medina-Solares",slug:"iliana-medina-solares",fullName:"Iliana Medina-Solares"}]},{id:"63913",title:"Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens",slug:"cytokine-profiling-plays-a-crucial-role-in-activating-immune-system-to-clear-infectious-pathogens",totalDownloads:3454,totalCrossrefCites:16,totalDimensionsCites:40,abstract:"Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response that recognizes pathogen-associated molecular patterns (PAMPs) and an antigen-specific adaptive immune response. In both responses, there are several activated cells of the immune system, which play a key role in establishing the environment of cytokines, thus directing their differentiation either suppressing or promoting the immune response. This immune response is crucial against pathogen infections. In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.",book:{id:"6963",slug:"immune-response-activation-and-immunomodulation",title:"Immune Response Activation and Immunomodulation",fullTitle:"Immune Response Activation and Immunomodulation"},signatures:"José Luis Muñoz-Carrillo, Juan Francisco Contreras-Cordero,\nOscar Gutiérrez-Coronado, Paola Trinidad Villalobos-Gutiérrez,\nLuis Guillermo Ramos-Gracia and Viridiana Elizabeth Hernández-Reyes",authors:[{id:"214236",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Muñoz-Carrillo",slug:"jose-luis-munoz-carrillo",fullName:"Jose Luis Muñoz-Carrillo"},{id:"216081",title:"Dr.",name:"Oscar",middleName:null,surname:"Gutiérrez-Coronado",slug:"oscar-gutierrez-coronado",fullName:"Oscar Gutiérrez-Coronado"},{id:"220717",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Contreras Cordero",slug:"juan-francisco-contreras-cordero",fullName:"Juan Francisco Contreras Cordero"},{id:"233193",title:"Dr.",name:"Paola Trinidad",middleName:null,surname:"Villalobos-Gutiérrez",slug:"paola-trinidad-villalobos-gutierrez",fullName:"Paola Trinidad Villalobos-Gutiérrez"},{id:"254015",title:"Dr.",name:"Viridiana Elizabeth",middleName:null,surname:"Hernández-Reyes",slug:"viridiana-elizabeth-hernandez-reyes",fullName:"Viridiana Elizabeth Hernández-Reyes"},{id:"257472",title:"Dr.",name:"Luis Guillermo",middleName:null,surname:"Ramos-Gracia",slug:"luis-guillermo-ramos-gracia",fullName:"Luis Guillermo Ramos-Gracia"}]},{id:"53240",title:"Staphylococcus aureus Biofilms and their Impact on the Medical Field",slug:"staphylococcus-aureus-biofilms-and-their-impact-on-the-medical-field",totalDownloads:3774,totalCrossrefCites:18,totalDimensionsCites:34,abstract:"Despite the discovery of antibiotics, the battle against bacteria is so far in their favor, specifically because bugs are able to develop a superstructure named biofilm, to resist and to survive in the environment. Nosocomial infections, a major health problem, are due at 80% to biofilm‐associated infection, and Staphylococcus aureus is the leading bacteria species in this domain. Moreover, the antimicrobial resistance of this bacterial community is accentuated when it is formed by superbugs such as methicillin‐resistant S. aureus (MRSA). In this chapter, the mechanism and the physiology of S. aureus biofilm as well as their consequences in the clinical domains are described. To complete the vision on S. aureus biofilms, some “anti‐biofilm” strategies will be highlighted.",book:{id:"6045",slug:"the-rise-of-virulence-and-antibiotic-resistance-in-staphylococcus-aureus",title:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus",fullTitle:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus"},signatures:"Fany Reffuveille, Jérôme Josse, Quentin Vallé, Céline Mongaret and\nSophie C. Gangloff",authors:[{id:"54351",title:"Prof.",name:"Sophie C.",middleName:null,surname:"Gangloff",slug:"sophie-c.-gangloff",fullName:"Sophie C. 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