Operational variable.
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Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"5461",leadTitle:null,fullTitle:"Hair and Scalp Disorders",title:"Hair and Scalp Disorders",subtitle:null,reviewType:"peer-reviewed",abstract:"This textbook contains the latest advances and scientific knowledge from the leading experts in hair biology, hair disorders, and clinical trichology. The book consists of ten sections in which hair biology, hair genetics, hair diagnostics, hair loss types, pathogenesis, treatment options, and restoration techniques are discussed. This book also emphasizes on various genetic and nongenetic alopecia types, differential diagnosis, and the measurement of hair loss. One chapter of the book is devoted to natural products for hair care and treatment. We believe that this textbook will serve as a comprehensive guide to many physicians dealing with hair disorders in their clinical practice.",isbn:"978-953-51-3098-7",printIsbn:"978-953-51-3097-0",pdfIsbn:"978-953-51-4857-9",doi:"10.5772/63002",price:139,priceEur:155,priceUsd:179,slug:"hair-and-scalp-disorders",numberOfPages:386,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"87c272cade1ee498e1b4d6051aa8d41e",bookSignature:"Zekayi Kutlubay and Server Serdaroglu",publishedDate:"May 3rd 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5461.jpg",numberOfDownloads:57418,numberOfWosCitations:18,numberOfCrossrefCitations:20,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:32,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:70,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 18th 2016",dateEndSecondStepPublish:"May 9th 2016",dateEndThirdStepPublish:"August 13th 2016",dateEndFourthStepPublish:"November 11th 2016",dateEndFifthStepPublish:"December 11th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"64792",title:"Dr.",name:"Zekayi",middleName:null,surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay",profilePictureURL:"https://mts.intechopen.com/storage/users/64792/images/5583_n.png",biography:"Zekayi Kutlubay, MD, is a chief physician of Istanbul University Cerrahpasa Medical Faculty Hospital. He is also an associate professor in the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty in Turkey. He has coauthored over 40 publications and supervised several master, doctoral, and postdoctoral students. His actual research interests are focused on psoriasis, pediatric dermatology, autoimmune bullous diseases, urticaria and allergic diseases, Behçet’s disease, vasculitis, lasers, cosmetic dermatology, facial rejuvenation, hair diseases, mesotherapy, botulinum toxin, and fillers.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Istanbul University Cerrahpaşa",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"64794",title:"Mr.",name:"Server",middleName:null,surname:"Serdaroglu",slug:"server-serdaroglu",fullName:"Server Serdaroglu",profilePictureURL:"https://mts.intechopen.com/storage/users/64794/images/5584_n.png",biography:"Server Serdaroglu, MD, is the head of the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty. He is also a professor in the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty in Turkey. He has coauthored over 30 publications and supervised several master, doctoral, and postdoctoral students. His actual research interests are focused on psoriasis, hair diseases, pediatric dermatology, autoimmune bullous diseases, urticaria and allergic diseases, lasers, and cosmetic dermatology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1003",title:"Trichology",slug:"trichology"}],chapters:[{id:"53795",title:"Introductory Chapter: Hair Loss",doi:"10.5772/66984",slug:"introductory-chapter-hair-loss",totalDownloads:2436,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Zekayi Kutlubay and Server Serdaroglu",downloadPdfUrl:"/chapter/pdf-download/53795",previewPdfUrl:"/chapter/pdf-preview/53795",authors:[{id:"64792",title:"Dr.",name:"Zekayi",surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay"}],corrections:null},{id:"53880",title:"Anatomy and Physiology of Hair",doi:"10.5772/67269",slug:"anatomy-and-physiology-of-hair",totalDownloads:7848,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:1,abstract:"Hair is one of the characteristic features of mammals and has various functions such as protection against external factors; producing sebum, apocrine sweat and pheromones; impact on social and sexual interactions; thermoregulation and being a resource for stem cells. Hair is a derivative of the epidermis and consists of two distinct parts: the follicle and the hair shaft. The follicle is the essential unit for the generation of hair. The hair shaft consists of a cortex and cuticle cells, and a medulla for some types of hairs. Hair follicle has a continuous growth and rest sequence named hair cycle. The duration of growth and rest cycles is coordinated by many endocrine, vascular and neural stimuli and depends not only on localization of the hair but also on various factors, like age and nutritional habits. Distinctive anatomy and physiology of hair follicle are presented in this chapter. Extensive knowledge on anatomical and physiological aspects of hair can contribute to understand and heal different hair disorders.",signatures:"Bilgen Erdoğan",downloadPdfUrl:"/chapter/pdf-download/53880",previewPdfUrl:"/chapter/pdf-preview/53880",authors:[{id:"193661",title:"Dr.",name:"Bilgen",surname:"Erdoğan",slug:"bilgen-erdogan",fullName:"Bilgen Erdoğan"}],corrections:null},{id:"53430",title:"Mechanism of Hair Loss from the Point of View of Epidermal Cell Polarity",doi:"10.5772/66735",slug:"mechanism-of-hair-loss-from-the-point-of-view-of-epidermal-cell-polarity",totalDownloads:2698,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The epidermis and hair follicle epithelium have a polarized stratified architecture, and epidermal homeostasis is maintained by stem cell and progenitor populations present in the basal layer of the interfollicular epidermis and in different compartments of the hair follicle. Atypical protein kinase Cs (aPKCs—a subgroup of the PKC family) are localized to tight junctions and regulate the apico-basal epithelial polarity in simple epithelia. In the stratified epidermis, aPKCs are expressed in the basal layer and are implicated in the regulation of oriented cell division by localizing to the apical pole of basal cells during mitosis. Mutant mice harboring epidermis-specific deletion of aPKCλ showed progressive hair loss, abnormal hair cycling, an increase of asymmetric cell division in the epidermis and hair follicles, and a gradual decrease in the hair follicle stem cell (HFSC) population. Lineage tracing analysis has demonstrated that mutant HFSCs lose their stemness and become more committed proliferating progenitors. Moreover, the expressions of quiescence-inducing factors (Bmp6 and Fgf18) were suppressed in the mutant hair follicles. These results clarify a novel function of aPKCλ in maintaining the quiescence of HFSCs and suggest that epidermal cell polarity is a new clue to understanding the pathogenesis of hair loss.",signatures:"Shin-Ichi Osada",downloadPdfUrl:"/chapter/pdf-download/53430",previewPdfUrl:"/chapter/pdf-preview/53430",authors:[{id:"190768",title:"Associate Prof.",name:"Shin-Ichi",surname:"Osada",slug:"shin-ichi-osada",fullName:"Shin-Ichi Osada"}],corrections:null},{id:"53304",title:"Hair Follicle Reconstruction and Stem Cells",doi:"10.5772/66707",slug:"hair-follicle-reconstruction-and-stem-cells",totalDownloads:2235,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"De novo hair follicle (HF) formation in embryonic skin and hair growth in postnatal skin are the result of epithelial-mesenchymal interactions between specialized mesenchymal dermal papilla (DP) and epithelial stem cells that give rise to hairs. Adult HF is a valuable source of different lineages of stem cells (SCs) with morphogenetic potential. Epithelial stem cells are residing in the special compartment of HF (the bulge) and can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. This review summarizes the current knowledge on key characteristics of HF SC populations in terms of regenerative potential. General biological principles that govern the mesenchymal-epithelial interactions within the HF and the signaling pathways that control HF development are discussed. The main focus is on recent approaches to reconstruct folliculogenesis in vitro and perspectives of the tissue engineering in alopecia therapy.",signatures:"Ekaterina P. Kalabusheva, Elina S. Chermnykh, Vasily V. Terskikh and\nEkaterina A. Vorotelyak",downloadPdfUrl:"/chapter/pdf-download/53304",previewPdfUrl:"/chapter/pdf-preview/53304",authors:[{id:"191045",title:"Dr.",name:"Ekaterina",surname:"Vorotelyak",slug:"ekaterina-vorotelyak",fullName:"Ekaterina Vorotelyak"},{id:"191046",title:"Ms.",name:"Ekaterina",surname:"Kalabusheva",slug:"ekaterina-kalabusheva",fullName:"Ekaterina Kalabusheva"},{id:"195509",title:"Prof.",name:"Vasily",surname:"Terskikh",slug:"vasily-terskikh",fullName:"Vasily Terskikh"},{id:"195510",title:"Dr.",name:"Elina",surname:"Chermnykh",slug:"elina-chermnykh",fullName:"Elina Chermnykh"}],corrections:null},{id:"54131",title:"The Histological Mechanisms of Hair Loss",doi:"10.5772/67275",slug:"the-histological-mechanisms-of-hair-loss",totalDownloads:2364,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The growing hair resists pulling out of the skin in particular site, where the keratinization of hair cortex and hair cuticle cells as well as the cells of the hair inner root sheath (IS) (being in tight contact) are advanced enough to make them rather strong but lower the level where the hair separates from the hair inner root sheath. The hair which does not grow is kept for some time within the skin by the direct contact of the keratinized hair cortex cells with the cells of the hair outer root sheath. Such contact is absent at the phase of growing hair and even in the case of proliferation inhibition in the follicle bulb causing the lack of hair resistance to pulling it out of the skin several days after inhibition induction.",signatures:"Vsevolodov Eduard Borisovich",downloadPdfUrl:"/chapter/pdf-download/54131",previewPdfUrl:"/chapter/pdf-preview/54131",authors:[{id:"191715",title:"Dr.",name:"Eduard",surname:"Vsevolodov",slug:"eduard-vsevolodov",fullName:"Eduard Vsevolodov"}],corrections:null},{id:"53525",title:"Trichoscopy and Trichogram",doi:"10.5772/66836",slug:"trichoscopy-and-trichogram",totalDownloads:2640,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hair and scalp examination techniques can be classified into three categories: noninvasive methods (clinical history, general examination, photography, hair count, weighing shed hair, pull test, global hair counts, dermoscopy, electron microscopy, laser scanning microscopy, etc.); semi‐invasive methods (the trichogram, unit areatrichogram); and invasive methods (biopsies in cicatritial alopecia). Scalp dermoscopy or trichoscopy is one of thenoninvasive techniques for the evaluation of patients with hair loss that allows for magnified visualization of the hair and scalp skin. It may be performed with a manual dermoscope (10× magnification) or a videodermoscope (up to 1000× magnification). This method is simple, quick, and easy to perform, is well‐accepted by patients, and is useful for monitoring treatment, determining severity of the disease and follow‐up. It is a simple, minimally invasive and rapid technique for measuring hair follicle activity. Trichogram represents a semi‐invasive technique for the evaluation of patients with hair loss that allows the microscopic examination of hairs plucked from the scalp and provides information about the state of the proximal end of the hair shaft and the distal end. The trichogram is a useful complementary tool for clinical evaluation, diagnosis, and the monitoring of treatment response.",signatures:"Melike Kibar",downloadPdfUrl:"/chapter/pdf-download/53525",previewPdfUrl:"/chapter/pdf-preview/53525",authors:[{id:"189899",title:"Dr.",name:"Melike",surname:"Kibar Ozturk",slug:"melike-kibar-ozturk",fullName:"Melike Kibar Ozturk"}],corrections:null},{id:"53231",title:"Alopecia Areata",doi:"10.5772/66594",slug:"alopecia-areata",totalDownloads:2588,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Alopecia areata is an organ-specific autoimmune disease targeting hair follicles. It causes nonscarring hair loss. The prevalence rate of the disease is approximately 1 in 1000 people worldwide. The condition is most commonly seen as circular areas of hair loss, but it may sometimes be as extensive as to involve the whole scalp or whole body. The complex pathophysiology of alopecia areata involves an autoimmune basis. Association of alopecia areata with other autoimmune diseases, such as thyroiditis and vitiligo, and the good response of patients to immunosuppressive treatment support an autoimmune etiology. Although some poor prognostic signs are defined, the course of the disease is unpredictable and the response to treatment can be variable. To date, there are neither preventive nor curative measures to deal with the condition. First-line therapy for patchy disease is topical and intralesional steroids, whereas extensive disease is conventionally managed with immunotherapy. New treatment agents, such as excimer laser, low-dose recombinant interleukin 2, Janus kinase inhibitors, and simvastatin/ezetimibe, are promising.",signatures:"Burhan Engin, Muazzez Çiğdem Oba and Yalçın Tüzün",downloadPdfUrl:"/chapter/pdf-download/53231",previewPdfUrl:"/chapter/pdf-preview/53231",authors:[{id:"64793",title:"Prof.",name:"Burhan",surname:"Engin",slug:"burhan-engin",fullName:"Burhan Engin"}],corrections:null},{id:"54176",title:"Telogen Effluvium",doi:"10.5772/66975",slug:"telogen-effluvium",totalDownloads:1984,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Telogen effluvium (TE) is a noninflammatory disease characterized by diffuse loss of telogen hair. It is the most frequent cause of diffuse hair loss and the actual incidence of the disease is not known. According to the underlying etiology, TE could be physiologically and pathologically classified. The evaluation of a patient with TE includes a detailed history, physical examination, and laboratory tests. The patients should be questioned in terms of TE subtype, duration, and clinical course of hair loss. The most important point in the treatment of TE is to consult about the natural course of the disease.",signatures:"Emin Ozlu and Ayse Serap Karadag",downloadPdfUrl:"/chapter/pdf-download/54176",previewPdfUrl:"/chapter/pdf-preview/54176",authors:[{id:"188975",title:"Associate Prof.",name:"Ayse Serap",surname:"Karadag",slug:"ayse-serap-karadag",fullName:"Ayse Serap Karadag"},{id:"189961",title:"Dr.",name:"Emin",surname:"Ozlu",slug:"emin-ozlu",fullName:"Emin Ozlu"}],corrections:null},{id:"54721",title:"Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways",doi:"10.5772/67845",slug:"androgenic-alopecia-cross-talk-between-cell-signal-transduction-pathways",totalDownloads:2969,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.",signatures:"Anastasia Nesterova and Anton Yuryev",downloadPdfUrl:"/chapter/pdf-download/54721",previewPdfUrl:"/chapter/pdf-preview/54721",authors:[{id:"189400",title:"Dr.",name:"Anastasia",surname:"Nesterova",slug:"anastasia-nesterova",fullName:"Anastasia Nesterova"},{id:"205662",title:"Dr.",name:"Anton",surname:"Yuryev",slug:"anton-yuryev",fullName:"Anton Yuryev"}],corrections:null},{id:"53933",title:"Cicatricial Alopecias",doi:"10.5772/67277",slug:"cicatricial-alopecias",totalDownloads:1794,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Primary cicatricial alopecias (PCA) are a rare group of disorders in which the hair follicle is the main target of destructive inflammation resulting in irreversible hair loss with scarring of affected lesions. Inflammation may predominantly involve lymphocytes or neutrophils. Cicatricial alopecias that mainly involve lymphocytic inflammation include lichen planopilaris, discoid lupus erythematosus, pseudopelade (Brocq), central centrifugal alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. Cicatricial alopecias that are due to predominantly neutrophilic inflammation include folliculitis decalvans and dissecting cellulitis of the scalp. Acne keloidalis, acne necrotica, and erosive pustular dermatosis are cicatricial alopecias with a mixed inflammatory infiltrate.",signatures:"Ibrahim Halil Yavuz, Goknur Ozaydin Yavuz and Serap Gunes Bilgili",downloadPdfUrl:"/chapter/pdf-download/53933",previewPdfUrl:"/chapter/pdf-preview/53933",authors:[{id:"190495",title:"Associate Prof.",name:"Serap Gunes",surname:"Bilgili",slug:"serap-gunes-bilgili",fullName:"Serap Gunes Bilgili"},{id:"191273",title:"Dr.",name:"Goknur",surname:"Ozaydin Yavuz",slug:"goknur-ozaydin-yavuz",fullName:"Goknur Ozaydin Yavuz"},{id:"191275",title:"Dr.",name:"Ibrahim Halil",surname:"Yavuz",slug:"ibrahim-halil-yavuz",fullName:"Ibrahim Halil Yavuz"}],corrections:null},{id:"53947",title:"Infections, Infestations and Neoplasms of the Scalp",doi:"10.5772/67278",slug:"infections-infestations-and-neoplasms-of-the-scalp",totalDownloads:3564,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter reviews common cutaneous infections, infestations, and neoplasms of the scalp. Infections of the scalp are subdivided into three major groups. The most seen are: (1) Bacterial: Folliculitis, folliculitis decalvans, tufted hair folliculitis and acne keloidalis nuchae. (2) Fungal: Tinea capitis, favus and kerion celsi. (3) Protozoal: Syphilitic alopecia. Pediculosis capitis is the most common worldwide infestation of the scalp. The neoplasms of the scalp are large group of different diseases due to arising different origin. In the following section, trichilemmal cyst, proliferating trichilemmal cyst, nevus sebaceous and cylindroma are discussed in detail.",signatures:"Filiz Canpolat",downloadPdfUrl:"/chapter/pdf-download/53947",previewPdfUrl:"/chapter/pdf-preview/53947",authors:[{id:"191617",title:"Associate Prof.",name:"Filiz",surname:"Canpolat",slug:"filiz-canpolat",fullName:"Filiz Canpolat"}],corrections:null},{id:"53306",title:"Trichotillomania and Traction Alopecia",doi:"10.5772/66746",slug:"trichotillomania-and-traction-alopecia",totalDownloads:2421,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Trichotillomania and traction alopecia are chronic habitual disorders characterized by repetitive pulling of hair that results in alopecia. They are commonly observed in children and adolescents but may present in adults due to occupational or traditional behavioral patterns. Trichotillomania (hair‐pulling disorder) has been described more than a century ago, but we still have very limited data about its etiology and treatment. It is classified under the obsessive‐compulsive and related disorders along with hoarding disorder, skin‐picking disorder (excoriation) and body dysmorphic disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5; American Psychiatric Association, May 2013). Traction alopecia is defined as loss of hair caused by repetitive or continuous and prolonged tension applied to the hair, usually on the scalp periphery and associated with mechanical traction of hair due to occupational behavioral patterns such as ballerinas or traditional behavioral patterns of hairstyles that cause tension. We aim to overview the clinical and diagnostic features of trichotillomania and traction alopecia and review the therapeutic options of these disorders in this chapter.",signatures:"Tugba Kevser Uzuncakmak, Melek Aslan Kayıran, Burak Tekin and\nFiliz Cebeci",downloadPdfUrl:"/chapter/pdf-download/53306",previewPdfUrl:"/chapter/pdf-preview/53306",authors:[{id:"193582",title:"Dr.",name:"Tugba Kevser",surname:"Uzuncakmak",slug:"tugba-kevser-uzuncakmak",fullName:"Tugba Kevser Uzuncakmak"},{id:"193587",title:"Dr.",name:"Filiz",surname:"Cebeci",slug:"filiz-cebeci",fullName:"Filiz Cebeci"},{id:"193588",title:"Dr.",name:"Melek",surname:"Aslan Kayıran",slug:"melek-aslan-kayiran",fullName:"Melek Aslan Kayıran"},{id:"193589",title:"Dr.",name:"Burak",surname:"Tekin",slug:"burak-tekin",fullName:"Burak Tekin"}],corrections:null},{id:"52801",title:"Psychosocial Aspects of Hair Loss",doi:"10.5772/66156",slug:"psychosocial-aspects-of-hair-loss",totalDownloads:2563,totalCrossrefCites:6,totalDimensionsCites:7,hasAltmetrics:1,abstract:"Hair loss (alopecia) is a common dermatological condition that affects men and women of all ages. It can be due to a wide variety of causes including scarring and non-scarring diseases. Although alopecia is not a life-threatening condition, it has significant psychological impact on the quality of life. Mental disorders such as anxiety, depression, social phobia, posttraumatic stress disorder, and suicidal thoughts are increased among alopecia patients. On the other hand, alopecia frequency increases during the course of psychological disorders. In this chapter, psychosocial aspects of hair loss and the relationship between alopecia and psychological disorders are reviewed.",signatures:"Hilal Gokalp",downloadPdfUrl:"/chapter/pdf-download/52801",previewPdfUrl:"/chapter/pdf-preview/52801",authors:[{id:"193580",title:"M.D.",name:"Hilal",surname:"Gokalp",slug:"hilal-gokalp",fullName:"Hilal Gokalp"}],corrections:null},{id:"54484",title:"Hair Loss in Children, Etiologies, and Treatment",doi:"10.5772/67379",slug:"hair-loss-in-children-etiologies-and-treatment",totalDownloads:2311,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hair loss in children is a common and important complaint in dermatology and pediatric clinics and can be considered as a difficult and challenging problem in some cases. Early management is needed as this has its effect on development of normal mental and physical growth of children. Alopecia or hair loss is of particular concern in pediatric group, as it is associated with more significant psychological consequences in this growing age group and has patterns that are different from that seen in adults. There are common and uncommon causes for this complaint, and this usually covers a broad differential diagnosis. This chapter has been written in an attempt to distinguish the types of hair loss (acquired and congenital, common and uncommon), to facilitate the diagnostic causes of this problem, and finally to reach a proper treatment.",signatures:"Khitam Al-Refu",downloadPdfUrl:"/chapter/pdf-download/54484",previewPdfUrl:"/chapter/pdf-preview/54484",authors:[{id:"51233",title:"Dr.",name:"Khitam",surname:"Al-Refu",slug:"khitam-al-refu",fullName:"Khitam Al-Refu"}],corrections:null},{id:"53490",title:"Follicular Unit Extraction (FUE) Hair Transplantation",doi:"10.5772/66837",slug:"follicular-unit-extraction-fue-hair-transplantation",totalDownloads:2528,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Throughout the world, over 60% of men and 50% of women suffer from androgenetic alopecia and irreversible hair loss. This type of hair loss is a seminatural process, and medication can only temporarily inhibit it. At the moment, the solution for either androgenetic alopecia or other irreversible hair loss problems is the hair transplantation. Besides androgenetic alopecia, the many irreversible hair losses are being applied successfully by hair transplantation. In the past 10–15 years, a new hair restoration technique was introduced. This method is called follicular unit extraction (FUE) technique. FUE is an alternative which allows for quick extraction of follicular unit grafts. The hair transplantation can be used in various problems such as alopecia areata, congenital alopecia, burn sequelae, eyelash-eyebrow loss, beard loss, and mustache loss. In addition, it can camouflage the scars. The main objective of hair transplantation is to restore hair loss. We may not be able to recreate the appearance that the patients had in their early twenties; however, realistic expectations can be met with the help of technology. Based on our experience, FUE is the method that gives us the opportunity to best meet all patients’ hair transplantation expectations.",signatures:"Safvet Ors",downloadPdfUrl:"/chapter/pdf-download/53490",previewPdfUrl:"/chapter/pdf-preview/53490",authors:[{id:"189369",title:"Dr.",name:"Safvet",surname:"Örs",slug:"safvet-ors",fullName:"Safvet Örs"}],corrections:null},{id:"54527",title:"Complications of Hair Transplantation",doi:"10.5772/66838",slug:"complications-of-hair-transplantation",totalDownloads:2594,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Recently, hair transplantation has been frequently commonly applied for aesthetic surgical procedures. Hair transplantation has a low complication rate compared to other aesthetic surgical procedures. However, it can cause serious complications if proper attention is not given. But there are a wide range of possible complications that are less severe and manageable. Common postoperative complications include pain, edema, asymmetry, bleeding, visible scarring, folliculitis, crusting, graft dislodgement, hiccups, effluvium, pruritus, and hypoesthesia. Other less common postoperative complications include hypertrophic scarring and keloid, arteriovenous fistula, infection, cobblestoning, syncope, pigment alteration, necrosis, granulomatous reaction, pyogenic granuloma, and Kaposi’s varicelliform eruptions. The most serious complication of hair transplantation is necrosis.",signatures:"Murat Küçüktaş",downloadPdfUrl:"/chapter/pdf-download/54527",previewPdfUrl:"/chapter/pdf-preview/54527",authors:[{id:"189869",title:"M.D.",name:"Murat",surname:"Küçüktaş",slug:"murat-kucuktas",fullName:"Murat Küçüktaş"}],corrections:null},{id:"53233",title:"New Modalities in the Treatment of Refractory Alopecia Areata",doi:"10.5772/66591",slug:"new-modalities-in-the-treatment-of-refractory-alopecia-areata",totalDownloads:1979,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Alopecia areata (AA) is a common and complex T-cell–mediated inflammatory disorder. It may be patchy (localized), involve the entire scalp (alopecia totalis) or entire body (alopecia universalis). Alopecia totalis and universalis are often difficult to treat. Although many therapeutic options currently exist in alopecia areata, none of them are curative or preventive. Besides, none of them are approved by Food and Drug Administration (FDA). The disease unfortunately has an unpredictable course. The factors indicating a poor prognosis are the extent of hair loss at the presentation, long duration of the disease, and ophiasis pattern of hair loss. There are only a few randomized controlled studies conducted on recalcitrant AA. Recent research on immunology of hair follicle and recent developments in immunopathogenesis, together with the shared pathways of the disease with other autoimmune disorders, led investigators to focus on novel therapies that target specific immunological pathways. Herein, we will review shortly the current treatment options in recalcitrant alopecia areata based on recently published studies and then will focus on the recently developed broad-spectrum and targeted therapeutics.",signatures:"Arzu Kılıç",downloadPdfUrl:"/chapter/pdf-download/53233",previewPdfUrl:"/chapter/pdf-preview/53233",authors:[{id:"189895",title:"Prof.",name:"Arzu",surname:"Kilic",slug:"arzu-kilic",fullName:"Arzu Kilic"}],corrections:null},{id:"54160",title:"Cosmetic Procedures in the Treatment of Alopecia",doi:"10.5772/66747",slug:"cosmetic-procedures-in-the-treatment-of-alopecia",totalDownloads:3394,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet‐rich plasma, low‐level light therapy, and stem‐cell therapy with variable outcomes are reviewed in this chapter.",signatures:"Selda Pelin Kartal, Cemile Altunel and Bilgen Gencler",downloadPdfUrl:"/chapter/pdf-download/54160",previewPdfUrl:"/chapter/pdf-preview/54160",authors:[{id:"72686",title:"Prof.",name:"Selda Pelin",surname:"Kartal",slug:"selda-pelin-kartal",fullName:"Selda Pelin Kartal"}],corrections:null},{id:"53297",title:"Alternative Medicine for Hair Loss",doi:"10.5772/66593",slug:"alternative-medicine-for-hair-loss",totalDownloads:6509,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In recent years, people have begun to give further emphasis to the external beauty, especially for their hair. Except drugs with proven effectiveness, complementary and alternative treatment options that have not yet been clarified of their effectiveness and side effect profiles have been used for centuries. Many plants or their extracts are widely used to prevent hair loss and treat alopecia (e.g., androgenetic alopecia, alopecia areata, or traction alopecia) worldwide, especially in Far Eastern countries. The mechanisms of action of these plants are still unknown. Although there are little randomized-controlled studies investigating the effectiveness in the treatment of hair loss, reported results have demonstrated that complementary and alternative medicine will become much more popular in the near future.",signatures:"Gurkan Yardimci",downloadPdfUrl:"/chapter/pdf-download/53297",previewPdfUrl:"/chapter/pdf-preview/53297",authors:[{id:"193590",title:"Dr.",name:"Gurkan",surname:"Yardimci",slug:"gurkan-yardimci",fullName:"Gurkan Yardimci"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5941",title:"Fundamentals of Sexually Transmitted Infections",subtitle:null,isOpenForSubmission:!1,hash:"213a3a4ce4fd55711c78e9a7acaf6939",slug:"fundamentals-of-sexually-transmitted-infections",bookSignature:"Server Serdaroglu and Zekayi Kutlubay",coverURL:"https://cdn.intechopen.com/books/images_new/5941.jpg",editedByType:"Edited by",editors:[{id:"64792",title:"Dr.",name:"Zekayi",surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3038",title:"Current Genetics in Dermatology",subtitle:null,isOpenForSubmission:!1,hash:"384a276072f522c3aea68f9d2a0dbfd8",slug:"current-genetics-in-dermatology",bookSignature:"Naoki Oiso",coverURL:"https://cdn.intechopen.com/books/images_new/3038.jpg",editedByType:"Edited by",editors:[{id:"32053",title:"Dr.",name:"Naoki",surname:"Oiso",slug:"naoki-oiso",fullName:"Naoki Oiso"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6961",title:"Alopecia",subtitle:null,isOpenForSubmission:!1,hash:"211055d552abe032133f7281ea2b13dd",slug:"alopecia",bookSignature:"Muhammad Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/6961.jpg",editedByType:"Edited by",editors:[{id:"204257",title:"Dr.",name:"Muhammad",surname:"Ahmad",slug:"muhammad-ahmad",fullName:"Muhammad Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Palatal Expansion (MARPE) and Suture Perforation: MARPE Guide",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/79422.pdf",downloadPdfUrl:"/chapter/pdf-download/79422",previewPdfUrl:"/chapter/pdf-preview/79422",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/79422",risUrl:"/chapter/ris/79422",chapter:{id:"78828",slug:"surgical-digitally-guided-planning-for-the-mini-screw-assisted-rapid-palatal-expansion-marpe-and-sut",signatures:"Cristiane Barros André, Bruno de Paula Machado Pasqua, José Rino Neto and Fábio Dupart Nascimento",dateSubmitted:"August 27th 2021",dateReviewed:"August 31st 2021",datePrePublished:"October 2nd 2021",datePublished:null,book:{id:"10780",title:"Current Trends in Orthodontics",subtitle:null,fullTitle:"Current Trends in Orthodontics",slug:"current-trends-in-orthodontics",publishedDate:"August 17th 2022",bookSignature:"Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",licenceType:"CC BY 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guide and support to those undergraduate, postgraduate students, and researchers interested in understanding the process of dynamical evaluation of discrete and continuous systems with behavior from fixed points to chaos and vice-versa, and also to those who are interested in the most recent knowledge about fixed points evolution to chaos. Some dynamical systems are designated to have well-defined behavior but under certain not previewed conditions, the behavior of those systems could evolve into a very complex dynamical response. By the use of adequate mathematical tools, the complex behavior produced by unstable fixed points could be studied, characterized, and in most cases controlled. Moreover, it is well known that systems evaluated from fractional calculus models are capable to present stable, and unstable fixed points, and variations of them under parametric modification or variation in the integration order, which also could be controlled under different control mechanisms.
",isbn:"978-1-83768-436-6",printIsbn:"978-1-83768-435-9",pdfIsbn:"978-1-83768-437-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"256aaeeb2cfa765c6a37c73e4fe7402f",bookSignature:"Dr. Guillermo Huerta-Cuellar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12020.jpg",keywords:"Stability of Fixed Points, Banach Fixed Points Theorem, Fractional Calculus, Discontinuity of Fixed Points, Stability of Systems, Route to Chaos, Multistability, Perturbations Theory, Unstable Fixed Points, Adaptive Control, Control of Discrete-Time Chaotic Systems, Pseudo-Random Bit Generator",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 17th 2022",dateEndSecondStepPublish:"July 15th 2022",dateEndThirdStepPublish:"September 13th 2022",dateEndFourthStepPublish:"December 2nd 2022",dateEndFifthStepPublish:"January 31st 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Guillermo Huerta Cuellar is a researcher in the area of nonlinear dynamics and chaotic systems, with experimental and theoretical results. Has been an author of more than 40 high-level papers, and academic editor in 4 journals, and 3 books.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"237167",title:"Dr.",name:"Guillermo",middleName:null,surname:"Huerta-Cuellar",slug:"guillermo-huerta-cuellar",fullName:"Guillermo Huerta-Cuellar",profilePictureURL:"https://mts.intechopen.com/storage/users/237167/images/system/237167.jpg",biography:"Guillermo Huerta Cuellar received a B.Sc. degree from Instituto de Investigación en\r\nComunicaciones Ópticas (IICO), from the Universidad Autónoma de San Luis Potosí, San Luis\r\nPotosí in 2004. After, he received a Ph.D. degrees from Centro de Investigaciones en Óptica\r\n(CIO), León Guanajuato, Mexico, in 2009. During 2010 to present he have been working at the\r\nExact Sciences and Technology Department in Centro Universitario de los Lagos, Universidad de\r\nGuadalajara. He has been Visiting Researcher in the department of Applied Mathematics at\r\nInstituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, México (2012-\r\n2014), in Department of Theory of Oscillations and Automatic Control, Faculty of Radiophysics,\r\nLobachevsky State University of Nizhny Novgorod, Russia (2016), sabbatical stay in the\r\nDepartment of Physics and Environmental Science at St. Mary's University, San Antonio, TX, US\r\n(2018-2019), and in División de Matemáticas Aplicadas, Instituto Potosino de Investigación\r\nCientífica y Tecnológica (IPICYT), in San Luis Potosí, S. L. P., México (2019-2020). He has\r\neditor of 3 books, and coauthor of 6 book chapters, international journals and conferences, and\r\nmore of 40 high impact publications. He is member in the National System for Researchers (SNI-\r\nCONACyT-México). He participates as Academic Editor in the Journal Complexity (2021),\r\nFrontiers in Applied Mathematics and Statistics (2022), and Axioms (2022). He has participations\r\nas a reviewer in high impact-factor journals. 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Understanding the rate of return can support cryptocurrency world is and how design choices affect investors. One threat to cryptocurrencies is high fluctuations in traders’ willingness to buy or sell [1]. The adoption of crypto assets has been a great concern for policy makers ever since Facebook announced its cryptocurrency, Libra, in June 2019 [2].
The technology behind these cryptocurrencies, a decentralized and open-source system named “blockchain” is often presented as one of the most innovative technology offering several many disruptive innovations in the next years [3, 4, 5, 6]. The crypto-currencies trading volume also has a granger-causality to energy consumption [7]. A crypto asset is an intangible digital asset whose issuance, sale or transfer are secured by cryptographic technology and shared electronically via a distributed ledger [8].
The era of digitalization of technology has given birth to the cryptocurrency Bitcoin (BTC) as a new exciting currency for the world community, including Indonesia. BTC is an alternative to complement the needs of global financial transactions that want convenience, efficiency and security. Use of the digital computing tools to process scientific, economic, and social information has changed the human capacity, considerably. Virtual space is being activated year over year being the result of efficient application of information resources [9].
The development of BTC is very rapid in Indonesia. Indonesia, which has a total population of 271,349 889 people in 2020 (BPS, 2021). The population of Indonesia is very potential for the growth of the investment climate for BTC.
Almost all countries in the world experienced a decline in economic growth in 2020 due to the 19 virus pandemic. However, BTC price growth showed a very significant increase in 2020. BTC prices recorded the best performance since 2013 amounting to 260 USD / BTC. The price of BTC is USD 12,310 in 2020 or an increase of 68.04% compared to 2019 amounting to USD 7,326 / BTC (investing, 2021). Table 1 shows the development of the value of BTC (USD / BTC) in 2010–2020.
Variable | Indicator | Measurement | Type of data | Source |
---|---|---|---|---|
Stock | Indonesia Composite Index | Average Stock Price/Baseline* | Ratio | www.investing.com |
Exchange Rate | Convert from USD to IDR currency | IDR/USD | Ratio | www.investing.com |
Gold | Gold price in USD per 1 Troy Ounce | USD/Troy Ounce | Ratio | www.harga-emas.org |
Bitcoin | Bitcoin price in USD per Bitcoin | USD/BTC | Ratio | www.investing.com |
Operational variable.
The baseline used to calculate the composite stock price index is the average price of the shares on August 10, 1982.
Source: various sources, 2021.
Indonesians who start investing in bitcoin currency can change the existing financial asset structure. The development of bitcoin currency in Indonesia can disturb the stability of the rupiah as the only valid currency for domestic transactions. Therefore, Bank Indonesia as the determinant of monetary policy has not or has not legalized bitcoin currency as a virtual currency in Indonesia.
This research aims to examine bitcoin cryptocurrency as an investment instrument opportunity compared to other investment instruments, namely stocks, gold and the rupiah exchange rate. For the government as policy makers, this research is expected to be an input for the development of digital currency in the era of information technology. In addition, for investors, this research is expected to illustrate the returns and risks faced when investing in bitcoin (Figure 1).
Bitcoin cryptocurrency graph 2010–2020 (USD/BTC). Source:
The study and analysis of the cryptocurrency market is a relatively new area. A few works published in recent years have had the potential interest in this topic. Many scientists have been studying Bitcoin from different angles ever since it appeared. Cryptocurrency is a digital currency, whose creation and control is based on cryptographic methods. Some researchers claim that Bitcoin is just a bubble. The fundamental value of Bitcoin is difficult to reveal, and history shows that innovative assets are indeed more prone to bubbles [10].
Bitcoin is the first decentralized peer-to-peer payment network that is fully controlled by its users without any central authority or intermediary. Bitcoin is a digital currency residing in an open source P2P (peer-to-peer) payment network. P2P is a computer network model that consists of two or more computers, where each computer in the network environment can share. This network makes it easy for users to transact directly without the need for services from third parties.
The elements of Bitcoin are the existence of a peer-to-peer network, blocks, blockchain, and miners. The peer-to-peer network in Bitcoin allows users to transfer a certain amount of Bitcoin value, these transactions are stored in files called blocks, these blocks are intertwined with each other to form a block chain called the blockchain, and miners solve complex mathematical formulas. to prove ownership of Bitcoin.
Bank Indonesia responds to the existence of Bitcoin if it can be used, traded, or stored as an asset or a form of digital commodity by the people of Indonesia, but it cannot be used as a means of payment because only the Rupiah currency is the only legal means of payment in Indonesia.
Bitcoin is the first implementation of the concept of cryptocurrency, which was first described by Wei Dai in 1998. The proposes of cryptocurrency is a new form of money that uses cryptography to control creation and transactions rather than using a centralized authority.
Cryptocurrency is a digital asset designed to function as a medium of exchange that uses strong cryptography to secure financial transactions, control the creation of additional units, and verify asset transfers.19 Cryptocurrency is a type of alternative currency and digital currency. Cryptocurrencies use decentralized controls compared to centralized digital currencies and central banking systems.
Cryptocurrency is a virtual currency that circulates without being regulated by a particular central bank, is not “backed up” with gold as currency, and is not protected by any particular country. Distribution and use through the internet network media. With this crypto many benefits are obtained without exchanging it for real money, the value of crypto prices has international standards so that the value is the same everywhere, the transfer time is very fast, and crypto is not owned by a particular company. Crypto is a digital asset where transactions are carried out using an online network. Crypto assets are virtual so if one wants to see what the physical form of this currency is, then the answer is no. The form is not like a physical currency issued by a bank and also not the currency of a country.
Investors can maximize asset allocation through a combination of risky assets to reduce high risk. Investors who have an aversion to risk tend to reject investments that are more likely to have speculative content. Investors who do not like risk consider risk-free investments or speculate on investments that have a positive premium.
Research related to virtual currency, especially bitcoin cryptocurrency, is still rarely done in Indonesia. However, the development of bitcoin cryptocurrency has recently begun so that further studies are needed to provide an overview to the public and policy makers regarding bitcoin cryptocurrency investment. Some of the research results that have been carried out both domestically and globally can be summarized as follows:
Voskobojnikov et al. [11] identified and qualitatively analyzed 6,859 reviews pertaining to the user experience with top five mobile cryptocurrency wallets. They suggested that both new and experienced users struggle with general and domain-specific user experience issues that, aside from frustration and disengagement, might lead to dangerous errors and irreversible monetary losses. They reveal shortcomings of current wallet user experience as well as users’ misconceptions, some of which can be traced back to a reliance on their understanding of conventional payment systems. Based on their findings, they provide recommendations on how to design cryptocurrency wallets that both alleviate the identified issues and counteract some of the misconceptions in order to better support newcomers.
Hachicha and Hachicha [12] proved the efficiency of Markov Chain for our sample and the convergence and stability for all parameters to a certain level. On the whole, it seems that permanent shocks have an effect on the volatility of the price of the bitcoin and also on the other stock market. Our results will help investors better diversify their portfolio by adding this cryptocurrency.
Mikhaylov, A. [10] conclude that the cryptocurrency market has entered a new stage of development, which means a reduced possibility to have excess profits when investing in the most liquid cryptocurrencies in the future. However, buying new high-risk tools provides opportunities for speculative income.
Igoni et al. [13] concluded that market capitalization and volume of digital currency did not constitute the significant variables of policy to influence the monetary policies in the South African economy, hence they operate independently. A decision to adopt and regulate digital currency operation or not in Nigeria does not affect. They recommend the Nigerian to embrace the digital environment in terms of regulations for tax advantage.
Le Tran and Leirvik [14] shown that the level of market-efficiency in the five largest cryptocurrencies is highly time-varying. Specifically, before 2017, cryptocurrency-markets are mostly inefficient. This corrobo-rates recent results on the matter. However, the cryptocurrency-markets become more efficient over time in the period 2017–2019. This contradicts other, more recent, results on the matter. The reason is that they apply a longer sample than previous studies. Another important reason is that they apply a robust measure of efficiency, being directly able to determine if the efficiency is significant or not. On average, Litecoin is the most efficient cryptocurrency, and Ripple being the least efficient cryptocurrency.
Agosto and Cafferata [15] found that extremely rapid price accelerations, often referred to as explosive behaviors, followed by drastic drops pose high risks to investors. From a risk management perspective, testing the explosiveness of individual cryptocurrency time series is not the only crucial issue.
Rabbani et al. [16] identified that the sharia compliance related to the cryptocurrency/Blockchain is the biggest challenge which Islamic Financial Technology organizations are facing. During our review we also find that Islamic Financial Technology organizations are to be considered as partners by the Islamic Financial Institutions (IFI’s) than the competitors. If Islamic Financial institutions want to increase efficiency, transparency and customer satisfaction they have to adopt Financial Technology and become partners with the Financial Tech companies.
Hairudin et al. [17] indicated that public embrace of cryptocurrencies continues to lag as the masses currently show reluctance in embracing cryptocurrencies as a complement, let alone a substitute to fiat counterparts. Governments have also successfully defended their sovereignty in preserving legal tender status, structural seignior age and exclusivity. Market-based studies hint at consistent inefficiencies across the spectrum. The most promising areas of research for crypto-financial intelligentsia would be delving into establishing trial runs for central bank-backed cryptocurrencies.
Grobys et al. [18] indicated that a variable moving average strategy is successful when using the 20 days moving average trading strategy. Specifically, excluding Bitcoin the technical trading rule generates an excess return of 8.76% p.a. after controlling for the average market return. The results suggest that cryptocurrency markets are inefficient.
Amsyar et al. [19] concluded that cryptocurrency has the disadvantage of not having the authority responsible for dealing with all problems that occur in all transactions, and money laundering crimes also often occur, this is a challenge for how to utilize cryptocurrency and blockchain technology in the current era of globalization.
Vaz de Melo and Fluminense [20] indicated that indicate that the strength of dependence among the crypto-currencies has increased over the recent years in the cointegrated crypto-market. The conclusions reached will help investors to manage risk while identifying opportunities for alternative diversified and profitable investments.
Tu et al. [21] detected two sudden jumps in the standard deviation, in the second quarter of 2017 and at the beginning of 2018, which could have served as the early warning signals of two major price collapses that have happened in the following periods. They propose a mean-field phenomenological model for the price of cryptocurrency to show how the use of the standard deviation of the residuals is a better leading indicator of the collapse in price than the time-series’ autocorrelation. Their findings represent a first step towards a better diagnostic of the risk of critical transition in the price and/or volume of crypto-currencies.
Fang et al. [22] summarized the existing research papers and results on cryptocurrency trading, including available trading platforms, trading signals, trading strategy research and risk management. This paper provides a comprehensive survey of cryptocurrency trading research, by covering 126 research papers on various aspects of cryptocurrency trading (e.g., cryptocurrency trading systems, bubble and extreme condition, prediction of volatility and return, crypto-assets portfolio construction and crypto-assets, technical trading and others). This paper also analyses datasets, research trends and distribution among research objects (contents/properties) and technologies, concluding with some promising opportunities that remain open in cryptocurrency trading.
Drożdż et al. [23] found that A particularly significant result is that the measures applied for detecting cross-correlations between the dynamics of the BTC/ETH and EUR/USD exchange rates do not show any noticeable relationships. This could be taken as an indication that the cryptocurrency market has begun decoupling itself from the Forex.
Panagiotidis et al. [24] found that a significant interaction between bitcoin and traditional stock market. The increased impact of Asian markets on Bitcoin compared to other geographically-defined markets. Two years after the Chinese regulatory interventions and the sudden construction of CNY’s share in bitcoin trading volume.
Aysan et al. [25] found that bitcoin can be considered as a hedging tool against global geopolitical risk.
Krafft et al. [1] found that individual “buy” actions led to short-term increases in subsequent buy-side activity hundreds of times the size of our interventions. From a design perspective, we note that the design choices of the exchange we study may have promoted this and other peer influence effects, which highlights the potential social and economic impact of HCI in the design of digital institutions.
Panagiotidis et al. [26] found that search intensity and gold returns emerge as the most important variables for bitcoin returns.
Koutmos [27] found that the contribution of return shocks to transaction activity is quantitatively larger in magnitude.
Demir et al. [28] found that bitcoin can serve as a hedging tools again uncertainty.
Balcilar et al. [29] found that non-linear relationship between bitcoin returns and trading volume. The trading volume cannot help to predict the volatility of returns at any point of the conditional distribution.
Urquhart [30] found that bitcoin return significantly inefficient but in the process of moving towards an efficient market.
Based on the research objectives, the researcher wants to compare the returns obtained from bitcoin currency and others investment instrument, namely stocks, exchange rates and gold to see how rate of return behavior on bitcoin currency. Besides measure rate of return on bitcoin currency, the researcher also measures the risk of bitcoin currency investment. Standard deviation of bitcoin currency employee to measure the risk of the investment. Thus, the statistical hypotheses and research hypotheses used in this study are as follows:
Ho1: μ₁ = μ₂.
Ha1: μ1 ≠ μ2.
Ho2: μ1 = μ3.
Ha2: μ1 ≠ μ3.
Ho3: μ1 = μ4.
Ha3: μ1 ≠ μ4.
Ho4: μ₁ = μ2 = μ3 = μ4.
Ha4: At least one of the average returns are not equal.
where:
μ1 = average bitcoin returns.
μ2 = average exchange rate returns.
μ3 = average gold returns.
μ4 = average stock returns.
While the research hypothesis developed in this study is as follows:
H01: There is no difference between the bitcoin returns and the exchange rate returns.
Ha1: There is a difference between the bitcoin returns and the exchange rate returns.
H02: There is no difference between the bitcoin returns stock and the gold returns gold.
Ha2: There is a difference between the bitcoin returns and the gold returns.
H03: There is no difference between the bitcoin returns and the stock returns.
Ha3: There is a difference between the bitcoin returns and the stock returns.
H04: There is no difference between the bitcoin returns and the others investment instrument.
Ha4: There is a difference between the bitcoin returns and the others investment instrument.
This study compares the return and risk of bitcoin, stocks, gold and the rupiah exchange rate. This research is a type of quantitative research using secondary data. Secondary data used in the study were obtained from www.investing.com [31]; for bitcoin and share prices. Gold prices were obtained from www.harga-emas.org [32]; Rupiah exchange rate is obtained from www.bi.go.id [33]. The research period from 2010 to 2020 used monthly data or 132 observed data.
The return calculation uses the formula for the difference from the current value to the previous value divided by the value in the previous period. In general, the return formula can be written as follows:
where:
Rt = the return at period t.
Rt-1 = the return at period t−1.
In this study also measure risk of each investment instruments. Standard deviation is employed to measure the risk of investments. Standard deviation to measure how far the deviation from the average of each investment instruments. The higher standard deviation value means the higher risk of the investment. Here the formula to measure standard deviation (σ):
where:
σ = standard deviation of investment.
n = number of observation.
r(s) = return of investment.
r = average of investment.
Table 1 shows the operational variables used in this study include investment instruments, namely bitcoin, exchange rates, gold and stock.
Statistical descriptions include the average, minimum value, maximum value and standard deviation of each investment instrument, namely bitcoin, exchange rate returns, gold returns and stock returns during the study period 2011–2020. Bitcoin’s return has the largest average of 18% compared with returns from other investment instruments. In addition, the standard deviation of bitcoin returns has the largest value of 61.08% compared to other investment instruments. The range of bitcoin returns between −38.87% till 470.88%. Table 2 shows the descriptive statistics of the investment instruments studied.
Instrument | N | Min | Max | Mean | Std. dev. |
---|---|---|---|---|---|
Bitcoin (μ1) | 120 | −0.3887 | 4.7088 | 0.1800 | 0.6108 |
Exchange Rate (μ2) | 120 | −0.0905 | 0.1367 | 0.0040 | 0.0258 |
Gold (μ3) | 120 | −0.1212 | 0.1363 | 0.0035 | 0.0472 |
Stock (μ4) | 120 | −0.1676 | 0.0944 | 0.0049 | 0.0415 |
Descriptive statistic.
Source: data processing, 2021.
The correlation matrix between investment instruments can be found in Table 3. The highest correlation is obtained from the return stock and return exchange rate (−0.602). The more the stock return increases, the lower the return exchange rate will be. In other words, the stronger the rupiah exchange rate, the more the composite stock price index will increase. The strengthening of the rupiah exchange rate had an impact on increasing domestic economic growth so that investors invested heavily in stocks. Therefore, stock returns also increase when there is an increase in the rupiah exchange rate. Meanwhile, bitcoin does not show a correlation with other investment instruments which is indicated by a correlation matrix value below 5%. This figure shows that the bitcoin returns are not affected by the others instruments investments returns namely exchange rate, gold and stock returns.
Instrument | Stock | Exchange Rate | Gold | Bitcoin |
---|---|---|---|---|
Stock | 1 | |||
Exchange Rate | −0.602 | 1 | ||
Gold | 0.218 | −0.258 | 1 | |
Bitcoin | 0.042 | 0.023 | −0.018 | 1 |
Correlation matrix.
Source: data processing, 2021.
An overview of the return fluctuations obtained from each investment instrument of stock return, exchange rate return, gold return and bitcoin return can be seen in Figures 2–5. Each investment instrument shows different return fluctuations. The lowest standard deviation is the exchange rate 2.58%, while the highest standard deviation is Bitcoin 61.08%. In other words, investment in bitcoin have the highest risk compared to the alternative investment instruments. The others investment instruments have low risk between 2.6% till 4.7%. Investment in foreign exchange rate has the lowest risk compared to the others alternative investments. Investment on gold and stock have similar risks around 4.2% to 4.7%.
The return stock 2011–2020. Source: data processing, 2021.
The return exchange rate 2011–2020. Source: data processing, 2021.
The return gold 2011–2020. Source: data processing, 2021.
Bitcoin return 2011–2020. Source: data processing, 2021.
The range of the largest fluctuation was obtained from the return on bitcoin investment, especially in the period 2012 to 2014. In 2013, bitcoin returns reached the highest point where returns increased from 10–70%. However, the return drastically decreased to (−5%) entering 2014. It means the investment in bitcoin get the highest return and also the highest risk compared to the others instrument of investment.
The next test was to compare the returns between each investment instrument through paired sample tests, namely stock-exchange rate, stock-gold, stock-bitcoin, exchange rate-gold, exchange rate-bitcoin and gold bitcoin. Table 4 shows the results of the paired sample test of each investment instrument.
Instrument | Mean | Std. dev. | Std. error mean | t | df | Sig. |
---|---|---|---|---|---|---|
Bitcoin - Ex. Rate | −0.1760 | 0.6108 | 0.0558 | −3.156 | 119 | 0.002 |
Bitcoin - Gold | −0.1765 | 0.6135 | 0.0560 | −3.151 | 119 | 0.002 |
Bitcoin - Stock | −0.1751 | 0.6105 | 0.0557 | −3.143 | 119 | 0.002 |
Paired samples test.
Source: data processing, 2021.
The results of the paired samples test of returns between investment instruments can be seen in Table 4. The results of the paired sample test between bitcoin and the others investment instruments shows significant level less than 0.01. It means that is difference of return between bitcoin and the others investment instruments. The average means difference of bitcoin and the others investment instruments around −17.6%. Standard deviations show around 61% of investment on bitcoin. It means that the highest risk of bitcoin investments.
Based on the results of testing paired samples test return on investment between investment instruments and the explanation above, it can be concluded that the research hypothesis is as follows:
Ha1: There is a difference between the bitcoin and the exchange rate return (accepted at significance level 0.01).
Ha2: There is a difference between the bitcoin and the gold return (accepted at significance level 0.01).
Ha3: There is a difference between the bitcoin and the stock return (accepted at significance level 0.01).
One sample test is conducted to prove whether or not there are differences between the investment instruments used in this study. The one sample test results show that bitcoin returns provide a very significant difference (α < 0.01) compared to other investment instruments: exchange rate, gold and stock. The average return of stock, exchange and gold investment instruments.
Table 5 shows analysis of variance single factor for each investment instruments. The variance of bitcoin the highest (0.37) if compared to stock, exchange rate and gold returns (0.001–0.002). It means there us a big different between bitcoin returns and the others investment instruments.
Groups | Count | Sum | Average | Variance |
---|---|---|---|---|
Stock return | 120 | 0.585183 | 0.004877 | 0.001723 |
Ex-Rate return | 120 | 0.483912 | 0.004033 | 0.000663 |
Gold Return | 120 | 0.422361 | 0.00352 | 0.002228 |
Bitcoin return | 120 | 21.60168 | 0.180014 | 0.373122 |
Anova single factor summary.
Source: data processing, 2021.
Table 6 shows analysis of variance to test hypothesis 4 whether there is significant level of the return. The result indicates that F calculation (0.9826) is higher than F critical value (2,624). It means there is significant different between bitcoin and the others investment instruments.
Source of variation | SS | df | MS | F | P-value | F crit |
---|---|---|---|---|---|---|
Between Groups | 2.783868 | 3 | 0.927956 | 9.826513 | 0.00000 | 2.623637 |
Within Groups | 44.95054 | 476 | 0.094434 | |||
Total | 47.73441 | 479 |
Anova single factor test.
Source: data processing, 2021.
Based on the results of the analysis of variance single factor test shows that there is a difference between the average return of all investment instruments. Thus, the statistical hypothesis and research hypothesis (Ha4) is accepted at significant level 0.01 or can be written down as follows:
Ha4: There is a difference between the investment instruments (accepted at significance level 0.01).
Based on the average test between the research instruments used, bitcoin has a very significant difference in return compared to other investment instruments. Meanwhile, stock investment instruments, exchange rate and gold have the same average return.
Based on the research results discussed in the previous chapter indicate that the investment in bitcoin still promising. The price of bitcoin rapidly increase during the study 2011–2020. The rate of return of bitcoin investment is the highest compared to the other investment instruments: stock, exchange rate and gold. Meanwhile, the bitcoin investment also has the highest risk compared the others investment instruments.
It can be concluded that bitcoin investment provides the highest return (18%) compared to other investment instrument returns. However, the very high return on bitcoin comes with high risk investment. The risk of investing in bitcoin is indicated by a standard deviation of 61%, while the standard deviation of other instruments: stock, exchange rate and gold less than 5%.
Based on the results of the paired sample test, it shows that the average return on bitcoin shows a very significant difference compared to the others instrument. Meanwhile, the return on the others instrument: stock, exchange rate and gold show the same return.
For the investors who love risk, then the investment in bitcoin could be an alternative for an investment. The investment on bitcoin promise higher return compare to the other investment instruments. For the investors who are risk aversion, an investment on bitcoin doesn’t fit since this investment have the highest risk.
This research has practical implication for the investors who require high return. In the same time, the investors also have to understand the risk along the investment on bitcoin.
The other implication for government of Indonesia as policy maker on crypto currency. The crypto currency quite develops rapidly in this crypto world era. The role and regulation on crypto currency are needed to secure investors and economic growth.
Oral cancer remains as a significant cause of mortality worldwide as most of these the tumors are detected and treated in late stages. The etiology of oral cancer is multifactorial. Tobacco and alcohol are still considered the main risk factors as about 80% of the patients who develop oral tumors are tobacco and/or alcohol users [1]. Additional etiologic factors have also been suggested such as infection by human papillomavirus (HPV) and other oncogenic viruses, immunosuppression states, genetic alterations, and deficient nutrition.
Dental implants are one of the top choices for the oral rehabilitation of partially or totally edentulous patients. The stability and comfort provided by the implants-anchored crowns are among their clinical advantages. Moreover, the success rate of dental implants surpasses 94.6% [2]. However, the soft tissue and supporting structures around the dental implants remain exposed to the oral cavity and may undergo pathological changes. The most frequent lesions are those of inflammatory nature triggered by the accumulation of bacterial biofilm. When the inflammatory lesion is confined to the soft tissue, it is named as peri-implant mucositis. On the other hand, when there is loss of supporting bone, the lesion is known as peri-implantitis. Due to the high incidence of peri-implant inflammatory diseases, some dental professionals treat the lesion but do not send the specimens to the microscopical analysis. About 3.6% of the lesions are malignant tumors (mainly squamous cell carcinomas, the most common malignancy of the oral cavity) [3]. In 2001, the first cases of malignant lesions developing around dental implants were published [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. Since then, the potential relationship of titanium implants with malignant tumor development has been discussed [1, 5, 13].
The aim of this chapter was to offer the readership the most recent information regarding the clinical features of oral cancer around dental implants, its differential diagnosis, and potential oncogenic mechanisms.
A review of literature available until September 2021 was conducted in the PubMed/Medline database using the term “Oral squamous cell carcinoma around dental implants.” Only cases with definitive microscopic diagnosis of OSCC arising in the soft tissue around one or more dental implants were included. The literature review revealed 43 cases of patients with OSCC around dental implants in the 19 published manuscripts [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. All clinical and epidemiological information about the sample is summarized in the Table 1.
Author | Gender/age | Cancer site | Lesion | Risk factors* | Prev. Rep. CA | Primary diagnosis |
---|---|---|---|---|---|---|
Block et al. 2001 [4] | M/72 | Mandible | Mimicked PI | Yes | Yes | PI |
Shaw et al. 2004 [5] | M/67 | Mandible | Exophytic mass | NA | Yes | PI |
F/69 | Mandible | Mimicked PI | NA | Yes | NA | |
Czerninski et al. [15] | F/52 | Mandible | Mimicked PI | Yes | No | PI |
M/80 | Mandible | Mimicked PI | No | Yes | PI | |
Abu El Naaj [16] | F/70 | Mandible | Exophytic white | No | Yes | NA |
Schache el al. [17] | F/77 | Mandible | Exophytic mass | No | No | NA |
Gallego et al. [18] | F/81 | Mandible | PI mass | No | Yes | OL |
Kwok et al. [19] | M/71 | Mandible | “Inflammatory process” | Yes | No | PI |
F/67 | Mandible | Exophytic mass | Yes | Yes | NA | |
M/62 | Mandible | Non-healing ulcer | Yes | No | Na | |
De Ceulaer et al. [20] | F/77 | Mandible | Mimicked PI | Yes | Yes | PI |
M/71 | Mandible | Swelling | Yes | Yes | PI | |
F/62 | Mandible | Mimicked PI | Yes | Yes | PI | |
Meijer et al. [21] | F/69 | Mandible | Exophytic mass | No | Yes | PI |
Orhan et al. [22] | F/69 | Mandible | Numb chin syndrome, with mixed RO-RL lesion | NA | Yes | NA |
Pfammatter et al. [6] | F/55 | Mandible | mimicked PI, numbness | Na | Yes | Metastasis |
Moergel et al. [7] | F/63 | Mandible | Exophytic mass | No | Yes | NA |
F/70 | Mandible | Exophytic mass | Yes | Yes | NA | |
M/72 | Mandible | Exophytic mass | No | Yes | NA | |
M/57 | Mandible | mimicked PI | Yes | Yes | PI | |
M/72 | Mandible | Exophytic mass | NA | No | NA | |
F/54 | Mandible | Exophytic mass | No | NA | NA | |
M/47 | Mandible | Ulcer | Yes | No | NA | |
M/88 | Mandible | Ulcer | No | No | NA | |
F/42 | Mandible | Ulcer | NA | Yes | NA | |
F/59 | Mandible | Ulcer | NA | Yes | NA | |
M/73 | Maxilla | Exophytic mass | Yes | Yes | NA | |
M/77 | Mandible | Exophytic mass | Yes | No | NA | |
F/68 | Mandible | Exophytic mass | Yes | Yes | NA | |
F/69 | Mandible | Exophytic mass | No | Yes | NA | |
Marini et al. [8] | F/51 | Mandible | Exophytic mass | No | No | PI |
Bhandari et al. [9] | F/71 | Maxilla | Erythematous | No | No | PI |
Chainani-Wu et al. [10] | F/60 | Maxilla | Fistula | No | No | PI |
Vadim Raiser et al. [11] | F/55 | Maxilla | White Exophytic mass | NA | NA | OL |
F/70 | Mandible | Erythematous mass | NA | NA | NA | |
Noguchi et al. [12] | F/65 | Mandible | gingival swelling | Yes | NA | Neoplasia |
Malthiéry et al. [13] | M/77 | Mandible | Mimicked PI | NA | No | PI |
Granados et al. [14] | M/83 | Mandible | Ulcerous lesion | NA | Yes | NA |
M/60 | Mandible | Verrucous lesion | NA | NA | NA | |
F/54 | Mandible | “Gum lesion” | NA | NA | NA | |
M/64 | Mandible | Excrescent lesion | NA | NA | NA |
Demographic and clinical features of patients diagnosed with oral squamous cell carcinoma around dental implants.
M = Male; F = Female; Pre.Rep.CA = Previously reported cancer; PI = Peri-implantitis; OL = Oral lichen planus; NA = Not available. * Patients who smokers and/or drinkers were considered.
The age of patients with oral cancer around dental implants ranged from 61 to 75 years old. There was a predominance of females (24 cases - 57.14%) when compared to males (18 cases - 42.86%). The typical clinical appearance of oral cancer around dental implants was an exophytic mass (20 tumors—47.62%) with few cases presenting as ulcer (4 tumors—9.52%). The bone osteolysis was frequently observed in the area of tumor causing the implant loss in some patients. The tumors affected mainly mandible (38 cases—90.47%) of the patients with multiples osseointegrated implants. Of note, oral cancer around dental implants is frequently clinically mistaken as peri-implantitis (Table 1).
Although peri-implantitis is the most common local risk factor for dental implant failure, the development of oral cancer involving the soft tissue around the titanium also impact the quality of life of the patient negatively. The oral cancer can manifest as hypertrophy, erythema, and/or ulcerative lesion of the soft tissue, and these features are similar to inflammatory peri-implant diseases such as peri-implantitis and/or peri-implant mucositis, as described by others [7, 10, 11]. Furthermore, these inflammatory peri-implant diseases frequently present the same epidemiological pattern and risk factors for oral cancer, that is, patients older than 60 years old and chronic tobacco and/or alcohol consumers [1]. Although there are protocols for peri-implantitis treatment, frequently, the peri-implant tissue removed during this surgical treatment is not submitted for histopathological analysis [23, 24]. Then, the number of reported cases of peri-implant malignancy seems to be low in mouth but it may be being underreported by health professionals [24]. Recently, in a study of 111 biopsies of peri-implant lesions, 3.6% of those had histopathological diagnosis of oral squamous cell carcinomas [3]. Another investigation demonstrated that 2.9% of 68 dental implant-related lesions were oral squamous cells carcinomas [25].
Figure 1 illustrates a case report of an edentulous 64-year-old woman. She had an exophytic mass associated with ulcerated area and covered by a yellowish membrane in the anterior region of the mandible. The lesion was surrounded multiple osseointegrated implants (Figure 1A). She did not report adverse habits, for example, tobacco or alcohol consumption. Periapical radiographic exhibited an ill-defined bone destruction underneath the area of the lesion (Figure 1B). The histopathological analysis exhibited keratinizing well-differentiated epithelial neoplastic cells, some undergoing atypical mitosis, and invading the subjacent fibrous connective tissue (Figure 1C). The diagnosis of oral cancer was confirmed.
Clinical and microscopic findings of oral squamous cell carcinoma around dental implants. a) Exophytic ulcer covered by necrotic tissue at the anterior-inferior alveolar ridge.b) Periapical radiograph showing an ill-defined bone loss in the peri-implant region. c) Neoplastic squamous epithelium-infiltrating subjacent submucosa with corneal pearls and discrete pleomorphism. d and e) epithelial cells with atypical mitotic figures infiltrating the tissue.
The early diagnosis of malignant tumors around dental implants is challenging because incipient lesions may resemble inflammatory peri-implant lesions [1, 2, 4, 5, 6, 7, 10, 12, 15, 16, 17, 18, 21]. In the Table 1, 14 out of 43 cases of oral cancer surrounding dental implants (33.33%) had the primary diagnosis of peri-implant lesions. Therefore, this clinical misinterpretation might delay the diagnosis of oral cancer facilitating its dissemination and resulting in a worst prognosis of the disease. These facts underscore how critical is the histological exam of every lesion around dental implants surgically removed. Furthermore, the peri-implant lesion that does not present the classical features of an inflammatory condition and that does not respond to conventional treatment, particularly if the patient has risk factor for oral cancer, should be submitted to the biopsy and histopathological analysis [23, 24, 25].
The etiology of oral cancer is multifactorial. OSCC is the most prevalent oral malignant tumor and it is associated with lifestyle risk factors such as alcohol consumption and smoking [26]. Curiously, tobacco smoking is also the predictor of dental implants failure and more smokers have post-operative infections and peri-implant crestal bone loss than nonsmokers [27, 28]. Although the information about lifestyle-related factors that predispose to oral cancer was incomplete in most of cases included in the Table 1, 34.88% of patients diagnosed with squamous cell carcinoma around dental implants were smokers and/or drinkers. These overlapping risk factors may drive the clinician to attribute the onset of an atypical lesion involving dental implants to a deficient or anomalous immune response of a patient who consumes tobacco and/or alcohol. However, it is essential that the clinicians are aware that the classic signs of inflammation persist in such patients and that these features are useful to distinguish a benign from a malignant lesion. Additionally, the histopathological analysis remains as the gold standard for the diagnosis of lesions located in the oral cavity [23].
A well-defined concept is that patients with previous history of cancer have higher risk of developing other tumors. Twenty-three (54.76%) of all cases of squamous cell carcinoma around dental implants arose in patients with history of cancer. Interestingly, we observed that 19 (82.60%) patients had OSCC previously. Furthermore, other patients had lung [6, 15], intestine [15], thyroid [17], and breast [17, 22] cancer previously. As the development of OSCC has been also associated with genomic instability and genetic predisposition [1], one can hypothesize that a patient who had a malignant lesion are more susceptible to local aggressions such as the contact of the soft tissue with dental implant materials.
Titanium is one of the most common components in implants alloys used in dental and medical fields [1, 29]. High biocompatibility, appropriate mechanical properties, inertness, and corrosion resistance are among the main advantages of titanium [25, 29, 30]. When the titanium implant is installed in extra oral sites, where it is protected from the contact with the environment, it has inert behavior. On the other hand, dental implants are continuously exposed to the oral cavity hostile conditions [31]. The area between the implants and the abutment or the prosthetic crown is particularly susceptible to the bacterial biofilm accumulation, saliva, pH and temperature changes, and functional micromotion (Figure 2) [31].
Illustration of potential risk factors and mechanisms on the development of squamous cell carcinoma around dental implants.
When the dental implant surface is exposed to any source of oxygen or nitrogen, a chemical reaction takes place and a thin layer of titanium dioxide (TiO2) is formed and deposited in the outer surface of the implants. This layer is extremely resistant to corrosion. However the chemical agents of the oral cavity can reduce the protection of the dioxide deposit and induce the corrosion development [31]. Saliva and other chemicals introduced into the oral cavity through feeding or in contact with bacterial biofilms influence the gradual biodegradation of metallic structures including the titanium used in dental implants [29]. Furthermore, acidic solution combined with mechanical friction strength potentiates the damages to the implants surfaces. Interestingly, some studies with cytology have demonstrated the presence of titanium particles in the peri-implant tissues [23, 25] regardless of the presence of peri-implantitis or peri-implant mucositis. It has been suggested that this material accumulation may be the result of the corrosive process of the dental implants [29, 30, 32], implant-abutment friction at the installation of the implants, and/or implantoplasty [29, 31, 33, 34]. The degree of titanium corrosion can be influenced by quality and quantity of saliva, diet, alloy polishing, genetics, oral hygiene, amount and distribution of the occlusal forces, and microbiota [29, 30, 32].
The above data show that titanium is not entirely bioinert as suggested years ago. Then, even with their good biological properties, titanium alloys are susceptible to corrosion attack with release of metal ions to the surrounding hard and soft oral tissues, lymph nodes, peripheral, and even distant organs [30]. Consequently, titanium ions have been implicated in the development of oral cancer around dental implants [1, 34].
As stated previously, the relationship between titanium dental implants and oral cancer has been suggested based on the increasing number of tumors arising in the peri-implant tissue. However, as far as we know, there is not any study dedicated to unveil the potential carcinogenic mechanisms triggered by titanium ions.
Titanium particles have been shown to induce the expression of breast cancer gene 1 (BRCA1) and checkpoint kinase 2 (CHK2) in epithelial cells
In 2006, the International Agency for Research on Cancer (IARC) classified the titanium dioxide as a possible carcinogen for humans [41]. However, in view of the few case reports of oral cancer around dental implants the authors were unable to exclude the existence of other confounding carcinogens as tobacco and/or alcohol [1, 7, 19].
The literature review showed that most cases of OSCC around dental implants had initial clinical features compatible with peri-implantitis. Therefore, this clinical misinterpretation of an inflammatory process in peri-implant mucosa may delay the diagnosis of oral cancer facilitating the local progression and dissemination of cancer cells, resulting in worst patient’s prognosis. Thus, the peri-implant lesion not responding to conventional anti-inflammatory treatment, particularly if the patient has risk factor for oral cancer, should be submitted to the biopsy and histopathological analysis, avoiding delay in the diagnosis of the tumor.
This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code (#001). We also thank Dr. Marcelo Júnior Zanda for providing the clinical images.
The authors declare they do not have conflict of interest.
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\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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Everyone must undergo this phase of life at his or her own time and pace. In the broader sense, ageing reflects all the changes taking place over the course of life. These changes start from birth—one grows, develops and attains maturity. To the young, ageing is exciting. Middle age is the time when people notice the age-related changes like greying of hair, wrinkled skin and a fair amount of physical decline. Even the healthiest, aesthetically fit cannot escape these changes. Slow and steady physical impairment and functional disability are noticed resulting in increased dependency in the period of old age. According to World Health Organization, ageing is a course of biological reality which starts at conception and ends with death. It has its own dynamics, much beyond human control. However, this process of ageing is also subject to the constructions by which each society makes sense of old age. In most of the developed countries, the age of 60 is considered equivalent to retirement age and it is said to be the beginning of old age. In this chapter, you understand the details of ageing processes and associated physiological changes.",book:{id:"6381",slug:"gerontology",title:"Gerontology",fullTitle:"Gerontology"},signatures:"Shilpa Amarya, Kalyani Singh and Manisha Sabharwal",authors:[{id:"226573",title:"Ph.D.",name:"Shilpa",middleName:null,surname:"Amarya",slug:"shilpa-amarya",fullName:"Shilpa Amarya"},{id:"226593",title:"Dr.",name:"Kalyani",middleName:null,surname:"Singh",slug:"kalyani-singh",fullName:"Kalyani Singh"},{id:"243264",title:"Dr.",name:"Manisha",middleName:null,surname:"Sabharwal",slug:"manisha-sabharwal",fullName:"Manisha Sabharwal"}]},{id:"55388",doi:"10.5772/intechopen.68944",title:"Beauty, Body Image, and the Media",slug:"beauty-body-image-and-the-media",totalDownloads:7768,totalCrossrefCites:5,totalDimensionsCites:12,abstract:"This chapter analyses the role of the mass media in people’s perceptions of beauty. We summarize the research literature on the mass media, both traditional media and online social media, and how they appear to interact with psychological factors to impact appearance concerns and body image disturbances. There is a strong support for the idea that traditional forms of media (e.g. magazines and music videos) affect perceptions of beauty and appearance concerns by leading women to internalize a very slender body type as ideal or beautiful. Rather than simply being passive recipients of unrealistic beauty ideals communicated to them via the media, a great number of individuals actually seek out idealized images in the media. Finally, we review what is known about the role of social media in impacting society’s perception of beauty and notions of idealized physical forms. Social media are more interactive than traditional media and the effects of self‐presentation strategies on perceptions of beauty have just begun to be studied. This is an emerging area of research that is of high relevance to researchers and clinicians interested in body image and appearance concerns.",book:{id:"5925",slug:"perception-of-beauty",title:"Perception of Beauty",fullTitle:"Perception of Beauty"},signatures:"Jennifer S. Mills, Amy Shannon and Jacqueline Hogue",authors:[{id:"202110",title:"Dr.",name:"Jennifer S.",middleName:null,surname:"Mills",slug:"jennifer-s.-mills",fullName:"Jennifer S. Mills"}]},{id:"59227",doi:"10.5772/intechopen.73385",title:"Differentiating Normal Cognitive Aging from Cognitive Impairment No Dementia: A Focus on Constructive and Visuospatial Abilities",slug:"differentiating-normal-cognitive-aging-from-cognitive-impairment-no-dementia-a-focus-on-constructive",totalDownloads:1353,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Constructive and visuospatial abilities in normal and in pathological aging (cognitive impairment, no dementia, CIND) are investigated. The sample includes 188 participants over 60 years of age, divided in 2 groups: healthy subjects (MMSE ≥28), without cognitive complaints, and individuals with CIND (MMSE between 24 and 27 and subjective cognitive complains). Drawing of cube and drawing of house, Benton Visual Retention Test (BVRT), and Block design are used to test the hypothesis that short visuoconstructive and visuospatial tests can distinguish normal from pathological cognitive aging in its very early stages. Results proved the discriminative sensitivity of BVRT general assessment criteria and of omissions and distortions in CIND. The diagnostic sensitivity of a modification of Moore and Wike [1984] scoring system for house and cube drawing tasks was confirmed as well. Drawing of cube and house could be used for quick screening of CIND in subjects over 60. Principal component analysis with oblimin rotation was performed to explore the different dimensions in the visuospatial and visuoconstructive abilities in old age. A four-factor structure was established, all four factors explaining 71% of the variance.",book:{id:"6381",slug:"gerontology",title:"Gerontology",fullTitle:"Gerontology"},signatures:"Radka Ivanova Massaldjieva",authors:[{id:"75907",title:"Associate Prof.",name:"Radka Ivanova",middleName:null,surname:"Massaldjieva",slug:"radka-ivanova-massaldjieva",fullName:"Radka Ivanova Massaldjieva"}]},{id:"59658",doi:"10.5772/intechopen.74748",title:"Ageing Better in the Netherlands",slug:"ageing-better-in-the-netherlands",totalDownloads:1193,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"The Dutch National Care for the Elderly Programme was an initiative organized by the Netherlands Organisation for Health Research and Development (ZonMw) between 2008 and 2016. The aim of the programme was to collect knowledge about frail elderly, to assess their needs and to provide person-centred and integrated care better suited to their needs. The budget of EUR 88 million was provided by the Dutch Ministry of Health, Welfare and Sports. Putting the needs of elderly people at the heart of the programme and ensuring their active participation were key to the programme’s success. The programme outcomes included the establishment of eight geriatric networks around the medical universities with 650 organisations and the completion of 218 projects. These projects, involving 43,000 elderly people and 8500 central caregivers, resulted in the completion of 45 PhD theses and the publication of more than 400 articles and the development of 300 practice toolkits, one database and a website, www.beteroud.nl. The Dutch National Care for the Elderly Programme has since developed into a movement and continues under the consortium Ageing Better, made up of eight organisations. Through the use of ambassadors, Ageing Better promotes the message that ageing is not a disease but a new phase of life.",book:{id:"6381",slug:"gerontology",title:"Gerontology",fullTitle:"Gerontology"},signatures:"Betty Meyboom-de Jong, Klaske Wynia and Anjo Geluk-Bleumink",authors:[{id:"224997",title:"Emeritus Prof.",name:"Betty",middleName:null,surname:"Meyboom-De Jong",slug:"betty-meyboom-de-jong",fullName:"Betty Meyboom-De Jong"},{id:"232900",title:"Dr.",name:"Klaske",middleName:null,surname:"Wynia",slug:"klaske-wynia",fullName:"Klaske Wynia"},{id:"232901",title:"Mrs.",name:"Anjo",middleName:null,surname:"Geluk-Bleumink",slug:"anjo-geluk-bleumink",fullName:"Anjo Geluk-Bleumink"}]},{id:"55890",doi:"10.5772/intechopen.69529",title:"Mindfulness Meditation and the Perception of Beauty: Implications for an Ecological Well-Being",slug:"mindfulness-meditation-and-the-perception-of-beauty-implications-for-an-ecological-well-being",totalDownloads:1428,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Meditation is a first-person method for contemplating ourselves and the world, with more than 2500 years of history, rooted in the philosophical and contemplative traditions of the east. The present chapter aims to explore this worldview in order to demonstrate its relevance to our capacity for the appreciation of beauty. To this end, the aesthetic experience, the contemplative experience and their relationship with the practice of mindfulness are analysed. We suggest that the contemplative meditative experience bestows a state of consciousness and acceptance of life which places the practitioner in a progressive encounter with a self-concept that begins to detach from a static sense of the self and from the categories that define it, so that it may be experienced as an ongoing mental event, removed from cultural ideals of beauty or positivity. The result of this de-identification from the static self is a greater degree of psychological flexibility and a more genuine way of seeing the world, leading to a new perception of the self that is connected to an experience of freedom, and contributes to one’s own well-being, as well as to that of others and of the environment.",book:{id:"5925",slug:"perception-of-beauty",title:"Perception of Beauty",fullTitle:"Perception of Beauty"},signatures:"Álvaro I. Langer, Carlos Schmidt and Edwin Krogh",authors:[{id:"199843",title:"Dr.",name:"Álvaro",middleName:null,surname:"Langer",slug:"alvaro-langer",fullName:"Álvaro Langer"},{id:"201865",title:"MSc.",name:"Carlos",middleName:null,surname:"Schmidt",slug:"carlos-schmidt",fullName:"Carlos Schmidt"},{id:"201866",title:"Dr.",name:"Edwin",middleName:null,surname:"Krogh",slug:"edwin-krogh",fullName:"Edwin Krogh"}]}],mostDownloadedChaptersLast30Days:[{id:"60564",title:"Ageing Process and Physiological Changes",slug:"ageing-process-and-physiological-changes",totalDownloads:6996,totalCrossrefCites:19,totalDimensionsCites:34,abstract:"Ageing is a natural process. Everyone must undergo this phase of life at his or her own time and pace. In the broader sense, ageing reflects all the changes taking place over the course of life. These changes start from birth—one grows, develops and attains maturity. To the young, ageing is exciting. Middle age is the time when people notice the age-related changes like greying of hair, wrinkled skin and a fair amount of physical decline. Even the healthiest, aesthetically fit cannot escape these changes. Slow and steady physical impairment and functional disability are noticed resulting in increased dependency in the period of old age. According to World Health Organization, ageing is a course of biological reality which starts at conception and ends with death. It has its own dynamics, much beyond human control. However, this process of ageing is also subject to the constructions by which each society makes sense of old age. In most of the developed countries, the age of 60 is considered equivalent to retirement age and it is said to be the beginning of old age. In this chapter, you understand the details of ageing processes and associated physiological changes.",book:{id:"6381",slug:"gerontology",title:"Gerontology",fullTitle:"Gerontology"},signatures:"Shilpa Amarya, Kalyani Singh and Manisha Sabharwal",authors:[{id:"226573",title:"Ph.D.",name:"Shilpa",middleName:null,surname:"Amarya",slug:"shilpa-amarya",fullName:"Shilpa Amarya"},{id:"226593",title:"Dr.",name:"Kalyani",middleName:null,surname:"Singh",slug:"kalyani-singh",fullName:"Kalyani Singh"},{id:"243264",title:"Dr.",name:"Manisha",middleName:null,surname:"Sabharwal",slug:"manisha-sabharwal",fullName:"Manisha Sabharwal"}]},{id:"55388",title:"Beauty, Body Image, and the Media",slug:"beauty-body-image-and-the-media",totalDownloads:7764,totalCrossrefCites:5,totalDimensionsCites:12,abstract:"This chapter analyses the role of the mass media in people’s perceptions of beauty. We summarize the research literature on the mass media, both traditional media and online social media, and how they appear to interact with psychological factors to impact appearance concerns and body image disturbances. There is a strong support for the idea that traditional forms of media (e.g. magazines and music videos) affect perceptions of beauty and appearance concerns by leading women to internalize a very slender body type as ideal or beautiful. Rather than simply being passive recipients of unrealistic beauty ideals communicated to them via the media, a great number of individuals actually seek out idealized images in the media. Finally, we review what is known about the role of social media in impacting society’s perception of beauty and notions of idealized physical forms. Social media are more interactive than traditional media and the effects of self‐presentation strategies on perceptions of beauty have just begun to be studied. This is an emerging area of research that is of high relevance to researchers and clinicians interested in body image and appearance concerns.",book:{id:"5925",slug:"perception-of-beauty",title:"Perception of Beauty",fullTitle:"Perception of Beauty"},signatures:"Jennifer S. Mills, Amy Shannon and Jacqueline Hogue",authors:[{id:"202110",title:"Dr.",name:"Jennifer S.",middleName:null,surname:"Mills",slug:"jennifer-s.-mills",fullName:"Jennifer S. Mills"}]},{id:"56505",title:"Aesthetics of the Naked Human Body: From Pornography (Sexualised Lust Object) to Iconography (Aesthetics of Human Nobility and Wisdom) in an Anthropology of Physical Beauty",slug:"aesthetics-of-the-naked-human-body-from-pornography-sexualised-lust-object-to-iconography-aesthetics",totalDownloads:2100,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In many religious circles and philosophies of life, the human body is excluded from the realm of spirituality and meaning. Due to a dualistic approach, nudity is viewed as merely a physical and corporeal category. In social media, there is the real danger that the naked human body is exploited for commercial gain. Advertisements often leave the impression that the body, very specifically the genitals, is designed merely for physical desire and corporeal chemistry. They become easily objects for lust, excluded from the beauty of graceful existence and noble courage. It is argued that the naked human body is not designed for pornographic exploitation and promiscuous sensuality but for compassionate intimacy and nurturing care in order to instil a humane dimension in human and sexual encounters. In this regard, antiquity and the Michelangelesque perspective can contribute to a paradigm shift from abusive exploitation to the beauty of vulnerable sensitivity. In order to foster an integrative approach to theory formation in anthropology, the methodology of stereometric thinking is proposed.",book:{id:"5925",slug:"perception-of-beauty",title:"Perception of Beauty",fullTitle:"Perception of Beauty"},signatures:"Daniel J Louw",authors:[{id:"200645",title:"Prof.",name:"Daniel",middleName:"Johannes",surname:"Louw",slug:"daniel-louw",fullName:"Daniel Louw"}]},{id:"56059",title:"A Plastic Surgeon’s Perspective on Stereotyping and the Perception of Beauty",slug:"a-plastic-surgeon-s-perspective-on-stereotyping-and-the-perception-of-beauty",totalDownloads:1918,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"In the world of plastic surgery, misconceptions may lead to irrational requests or outcomes not appreciated by patients. Those who manage aesthetics should always listen and recognize the variability of cultural identities, desires, attitudes, anxieties and uncertainties of the patient. Emerging from a diversity of cultures and its transforming trends, the scope of cosmetic surgery and its practice reflect not only the individual’s personality, but also the culture as a whole. When counseling an individual, one has to recognize that even in groups of seemingly identical social or cultural standards; there are subtle differences in expectations. To illustrate the potential for inaccuracy of ethnic profiling in the field of plastic surgery authors quote their own work on Asian subjects and facial beauty and resort to experience of others. To reaffirm their opinion and to exemplify how sometimes “fine” differences in the perception of beauty exist, an original study that evaluates the preferences among selected groups of Latina women in respect to buttock aesthetics has been included. This dissertation will focus on how cultural factors influence beauty perception; strengthen the fact that beauty is in the eye of the beholder and how variable differences exist even between small subgroups.",book:{id:"5925",slug:"perception-of-beauty",title:"Perception of Beauty",fullTitle:"Perception of Beauty"},signatures:"Johanna D’Agostino and Marek Dobke",authors:[{id:"17590",title:"Dr.",name:"Marek K.",middleName:null,surname:"Dobke",slug:"marek-k.-dobke",fullName:"Marek K. Dobke"},{id:"201244",title:"Dr.",name:"Johanna",middleName:null,surname:"D'Agostino",slug:"johanna-d'agostino",fullName:"Johanna D'Agostino"}]},{id:"80326",title:"Anti-Senescence Therapy",slug:"anti-senescence-therapy",totalDownloads:110,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The development of therapeutic strategies aimed at the aging process of cells has attracted increasing attention in recent decades due to the involvement of this process in the development of many chronic and age-related diseases. Interestingly, preclinical studies have shown the success of a number of anti-aging approaches in the treatment of a range of chronic diseases. These approaches are directed against aging processes such as oxidative stress, telomerase shortening, inflammation, and deficient autophagy. Many strategies has been shown to be effective in delaying aging, including antiaging strategies based on establishing healthy lifestyle habits and pharmacological interventions aimed at disrupting senescent cells and senescent-associated secretory phenotype. Caloric restriction and intermittent fasting were reported to activate autophagy and reduce inflammation. In turn, immune-based strategies, senolytic agents, and senomorphics mediate their effects either by eliminating senescent cells through inducing apoptosis or by disrupting pathways by which senescent cells mediate their detrimental effects. In addition, given the association of the decline in the regenerative potential of stem cells with aging, many experimental and clinical studies indicate the effectiveness of stem cell transplantation in preventing or slowing the progress of age-related diseases by enhancing the repairing mechanisms and the secretion of many growth factors and cytokines.",book:{id:"10935",slug:null,title:"Mechanisms and Management of Senescence",fullTitle:"Mechanisms and Management of Senescence"},signatures:"Raghad Alshadidi",authors:null}],onlineFirstChaptersFilter:{topicId:"235",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82112",title:"Comparative Senescence and Lifespan",slug:"comparative-senescence-and-lifespan",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.105137",abstract:"The word senescence is derived from the Latin word “senex” (meaning old). In biology, senescence is a process by which a cell ages and permanently stops dividing. Senescence is a natural universal phenomenon affecting all living organisms (e.g., humans, animals, and plants). It is the process of growing old (aging). The underlying mechanisms of senescence and aging at the cellular level are not fully understood. Senescence is a multifactorial process that can be induced by several stimuli including cellular stress, DNA damage, telomere shortening, and oncogene activation. The most popular theory to explain aging is the free radical theory. Senescence plays a role in the development of several age-related chronic diseases in humans (e.g., ischemic heart disease, osteoporosis, and cancer). Lifespan is a biological characteristic of every species. The lifespan of living organisms ranges from few hours (with mayfly) to potential eternity (with jellyfish and hydra). The maximum theoretical lifespan in humans is around 120 years. The lifespan in humans is influenced by multiple factors including genetic, epigenetic, lifestyle, environmental, metabolic, and endocrine factors. There are several ways to potentially extend the lifespan of humans and eventually surpass the maximum theoretical lifespan of 120 years. The tools that can be proposed include lifestyle, reduction of several life-threatening diseases and disabilities, hormonal replacement, antioxidants, autophagy inducers, senolytic drugs, stem cell therapy, and gene therapy.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Hassan M. Heshmati"},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.103102",abstract:"The increasing trend of life-expectancy is becoming a significant demographic, societal and economic challenge. Currently, global number of people above sixty years of age is 900 million, while United Nations expect this number to rise to over 1.4 billion in 2030 and over 2.5 billion by 2050. Concordant to this trend, numerous physiological changes are associated with aging and brain-related ones are associated with neuropsychiatric diseases. The main goal of this chapter is to identify the most important neuropsychiatric diseases to assess in older patients to help to promote health and prevent diseases and complications associated with chronic illness, as these changes are progressive and require important psychological and setting-related social adjustments. Findings identify several health-aspects highly present in elderly: stroke, white matter lesions, dementia rise with age, changes in levels of neurotransmitters and hormones, depression as well as the bereavement following loss of the loved one, and the most common neurodegenerative disease—Alzheimer’s disease and Parkinson’s. In conclusion, studying the aging process should include all developmental, circumstantial, and individual aspects of aging. This offers opportunities to improve the health of elderly by using a wide range of skills and knowledge. Thus, further studies are necessary to elucidate what can be done do to improve the aging process and health of elderly in the future.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Jelena Milić"},{id:"80326",title:"Anti-Senescence Therapy",slug:"anti-senescence-therapy",totalDownloads:111,totalDimensionsCites:0,doi:"10.5772/intechopen.101585",abstract:"The development of therapeutic strategies aimed at the aging process of cells has attracted increasing attention in recent decades due to the involvement of this process in the development of many chronic and age-related diseases. Interestingly, preclinical studies have shown the success of a number of anti-aging approaches in the treatment of a range of chronic diseases. These approaches are directed against aging processes such as oxidative stress, telomerase shortening, inflammation, and deficient autophagy. Many strategies has been shown to be effective in delaying aging, including antiaging strategies based on establishing healthy lifestyle habits and pharmacological interventions aimed at disrupting senescent cells and senescent-associated secretory phenotype. Caloric restriction and intermittent fasting were reported to activate autophagy and reduce inflammation. In turn, immune-based strategies, senolytic agents, and senomorphics mediate their effects either by eliminating senescent cells through inducing apoptosis or by disrupting pathways by which senescent cells mediate their detrimental effects. In addition, given the association of the decline in the regenerative potential of stem cells with aging, many experimental and clinical studies indicate the effectiveness of stem cell transplantation in preventing or slowing the progress of age-related diseases by enhancing the repairing mechanisms and the secretion of many growth factors and cytokines.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Raghad Alshadidi"},{id:"79828",title:"Cellular Senescence in Bone",slug:"cellular-senescence-in-bone",totalDownloads:119,totalDimensionsCites:0,doi:"10.5772/intechopen.101803",abstract:"Senescence is an irreversible cell-cycle arrest process induced by environmental, genetic, and epigenetic factors. An accumulation of senescent cells in bone results in age-related disorders, and one of the common problems is osteoporosis. Deciphering the basic mechanisms contributing to the chronic ailments of aging may uncover new avenues for targeted treatment. This review focuses on the mechanisms and the most relevant research advancements in skeletal cellular senescence. To identify new options for the treatment or prevention of age-related chronic diseases, researchers have targeted hallmarks of aging, including telomere attrition, genomic instability, cellular senescence, and epigenetic alterations. First, this chapter provides an overview of the fundamentals of bone tissue, the causes of skeletal involution, and the role of cellular senescence in bone and bone diseases such as osteoporosis. Next, this review will discuss the utilization of pharmacological interventions in aging tissues and, more specifically, highlight the role of senescent cells to identify the most effective and safe strategies.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Danielle Wang and Haitao Wang"},{id:"79668",title:"Identification of RNA Species That Bind to the hnRNP A1 in Normal and Senescent Human Fibroblasts",slug:"identification-of-rna-species-that-bind-to-the-hnrnp-a1-in-normal-and-senescent-human-fibroblasts",totalDownloads:81,totalDimensionsCites:0,doi:"10.5772/intechopen.101525",abstract:"hnRNP A1 is a member of the hnRNPs (heterogeneous nuclear ribonucleoproteins) family of proteins that play a central role in regulating genes responsible for cell proliferation, DNA repair, apoptosis, and telomere biogenesis. Previous studies have shown that hnRNPA1 had reduced protein levels and increased cytoplasmic accumulation in senescent human diploid fibroblasts. The consequence of reduced protein expression and altered cellular localization may account for the alterations in gene expression observed during senescence. There is limited information for gene targets of hnRNP A1 as well as its in vivo function. In these studies, we performed RNA co-immunoprecipitation experiments using hnRNP A1 as the target protein to identify potential mRNA species in ribonucleoprotein (RNP) complexes. Using this approach, we identified the human double minute 2 (HDM2) mRNA as a binding target for hnRNP A1 in young and senescent human diploid fibroblasts cells. It was also observed that alterations of hnRNP A1 expression modulate HDM2 mRNA levels in young IMR-90 cells. We also demonstrated that the levels of HDM2 mRNA increased with the downregulation of hnRNP A1 and decrease with the overexpression of hnRNP A1. Although we did not observe a significant decrease in HDM2 protein level, a concomitant increase in p53 protein level was detected with the overexpression of hnRNP A1. Our studies also show that hnRNP A1 directly interacts with HDM2 mRNA at a region corresponding to its 3′ UTR (untranslated region of a gene). The results from this study demonstrate that hnRNP A1 has a novel role in participating in the regulation of HDM2 gene expression.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Heriberto Moran, Shanaz A. Ghandhi, Naoko Shimada and Karen Hubbard"},{id:"79295",title:"Genetic and Epigenetic Influences on Cutaneous Cellular Senescence",slug:"genetic-and-epigenetic-influences-on-cutaneous-cellular-senescence",totalDownloads:136,totalDimensionsCites:0,doi:"10.5772/intechopen.101152",abstract:"Skin is the largest human organ system, and its protective function is critical to survival. The epithelial, dermal, and subcutaneous compartments are heterogeneous mixtures of cell types, yet they all display age-related skin dysfunction through the accumulation of an altered phenotypic cellular state called senescence. Cellular senescence is triggered by complex and dynamic genetic and epigenetic processes. A senescence steady state is achieved in different cell types under various and overlapping conditions of chronological age, toxic injury, oxidative stress, replicative exhaustion, DNA damage, metabolic dysfunction, and chromosomal structural changes. These inputs lead to outputs of cell-cycle withdrawal and the appearance of a senescence-associated secretory phenotype, both of which accumulate as tissue pathology observed clinically in aged skin. This review details the influence of genetic and epigenetic factors that converge on normal cutaneous cellular processes to create the senescent state, thereby dictating the response of the skin to the forces of both intrinsic and extrinsic aging. From this work, it is clear that no single biomarker or process leads to senescence, but that it is a convergence of factors resulting in an overt aging phenotype.",book:{id:"10935",title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg"},signatures:"Tapash Jay Sarkar, Maiko Hermsmeier, Jessica L. Ross and G. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:6,paginationItems:[{id:"82526",title:"Deep Multiagent Reinforcement Learning Methods Addressing the Scalability Challenge",doi:"10.5772/intechopen.105627",signatures:"Theocharis Kravaris and George A. 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He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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