Mike Barbeck has vast experience in regenerative biomedical research working at institutes in Germany. He has researched the principles of biomaterial-mediated tissue regeneration (bone substitute materials and collagen materials) resulting in many papers in peer-reviewed journals. His research has led to further elucidation of cellular fundamentals of the foreign body response to different biomaterials.
Bone healing and regeneration is a complex process that can become impaired by disease or the size of a bone fracture or defect. In these instances, bone grafting can be used to aid the regeneration process. Bone grafting materials can be divided into autologous, allogenic, xenogeneic, and alloplastic, and are used to fill the defect/fracture void, thereby providing stability and supporting the infiltration of surrounding bone. This book will cover the most important fundamentals of bone grafting and provide an overview of current and future trends in bone graft research. Over the course of this book, the reader will learn about the most recent advancements in bone tissue biomaterials, the different fabrication techniques of bone tissue scaffolds, and the interaction of bone graft implant materials with the body by their induced cell and tissue reactions. Overall, this book provides an insight into bone grafting and the requirements for successful bone regeneration.
Go to the bookBioprinting is an emerging field in the areas of tissue engineering and regenerative medicine. It is defined as the printing of structures consisting of living cells, biomaterials and active biomolecules. The ultimate aim is to produce implantable organs and tissues to replace the use of autografts, which cause donor site morbidity and require two invasive surgeries. Not only is bioprinting aimed at the restoration of tissue, it has significant potential for drug delivery and cancer studies. Bioprinting provides control over cell placement and therefore creates a homogenous distribution of cells correlating to a uniform tissue ingrowth. Another attribute of bioprinting is the production of patient-specific spatial geometry, controllable microstructures and a high degree of reproducibility and scalability between designs. This book chapter will discuss the many parameters of bioprinting; manufacturing techniques, precursor materials, types of printed cells and the current research.
Part of the book: Biomaterial-supported Tissue Reconstruction or Regeneration