Periodontitis is defined as an inflammatory disease of supporting tissues of teeth characterized by progressive destruction of the periodontal ligament and alveolar bone. Periodontal manifestations of these genetic disorders or syndromes, such as familial and cyclic neutropenias, granulomatous disease, agranulocytosis, Langerhans’ cell disease, glycogen storage disease, hypophosphatasia, leucocyte adhesion deficiency, and Papillon‐Lefèvre, Chédiak‐Higashi, Cohen, Ehlers‐Danlos, Marfan, Down, Haim‐Munk, and Kindlers syndromes, imitate some types of periodontal diseases. Most of these syndromes have autosomal‐recessive characterization and can be seen commonly in consanguineous marriages. Therefore, consanguineous marriages have generally been accepted as having important detrimental effects on offspring. There is a lot of genetic research about consanguineous marriage and its detrimental effects on offspring. Although consanguineous marriages are common in the world, the relationship with oral and periodontal diseases has not been thoroughly investigated. We do not have enough of an understanding of the effects of consanguineous marriage on oral and periodontal diseases. In this chapter, previous studies in the literature related to this subject will be investigated and evaluated, and then this research will be related to oral and periodontal diseases. Therefore, this chapter will guide further research. The aim of this chapter is to show the relation between consanguineous marriages and oral‐periodontal diseases.
Part of the book: Insights into Various Aspects of Oral Health
Excessive reactive oxygen species production plays an important role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease. Reactive oxygen species could damage the cells and the tissues. In the pathogenesis of periodontal diseases, the increased PMN count and activity cause a high rate of ROS release. This leads to increased oxidative stress in periodontal tissues. Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Therefore, this chapter focuses on the effects of antioxidant on periodontal tissues.
Part of the book: Gingival Disease