Values of the calibration certificate of a thermometer.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"9206",leadTitle:null,fullTitle:"Importance of Selenium in the Environment and Human Health",title:"Importance of Selenium in the Environment and Human Health",subtitle:null,reviewType:"peer-reviewed",abstract:"Importance of Selenium in the Environment and Human Health contains a number of recent studies of the effect of selenium on environmental and human health. There are several issues related to environmental selenium and human health. A link has been noted between selenium status in soil-plants-human body, such as plants that extract selenium from the soil parenthetically, the influence of selenium content on food, the necessity for selenium supplementation in the common population, and the therapeutic effects of selenium in various diseases. This book explores the connection and interrelationships between selenium in the environment, plants, agriculture, biology, human health, animals, and molecular and biochemistry processes. It is an important book for research organizations, governmental research centers, academic libraries, and R&D facilities affiliated to recent research and studies of the effect of selenium on environmental and human health.",isbn:"978-1-78985-868-6",printIsbn:"978-1-78985-867-9",pdfIsbn:"978-1-78984-312-5",doi:"10.5772/intechopen.83202",price:100,priceEur:109,priceUsd:129,slug:"importance-of-selenium-in-the-environment-and-human-health",numberOfPages:94,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"e21bd2a386a2d078fe53a4d1658e44bf",bookSignature:"Mohammed Muzibur Rahman, Abdullah Mohamed Asiri, Anish Khan and Inamuddin",publishedDate:"March 25th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9206.jpg",numberOfDownloads:4311,numberOfWosCitations:6,numberOfCrossrefCitations:8,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:12,numberOfDimensionsCitationsByBook:3,hasAltmetrics:0,numberOfTotalCitations:26,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 14th 2019",dateEndSecondStepPublish:"August 28th 2019",dateEndThirdStepPublish:"October 27th 2019",dateEndFourthStepPublish:"January 15th 2020",dateEndFifthStepPublish:"March 15th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",middleName:null,surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/24438/images/system/24438.jpg",biography:"Prof. Mohammed Muzibur Rahman received his BSc and MSc from Shahjalal University of Science & Technology, Sylhet, Bangladesh, in 1999 and 2001, respectively. He received his Ph.D. from Chonbuk National University, South Korea, in 2007. He worked as a postdoctoral fellow and assistant professor in pioneering research centers and universities located in South Korea, Japan, and Saudi Arabia. Presently, he is an associate professor at the Center of Excellence for Advanced Materials Research (CEAMR) and Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He has published more than 245 international and domestic conferences and several book chapters. He has also edited ten books. His research interests include photocatalysis, semiconductors, nanoparticles, carbon nanotubes, nanotechnology, electrocatalysis, sensors, ionic liquids, surface chemistry, electrochemistry, and nanomaterials.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"11",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"289905",title:"Dr.",name:null,middleName:null,surname:"Inamuddin",slug:"inamuddin",fullName:"Inamuddin",profilePictureURL:"https://mts.intechopen.com/storage/users/289905/images/system/289905.jpeg",biography:"Dr. Inamuddin is currently an assistant professor in the Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. He has extensive research experience in multidisciplinary fields of analytical chemistry, materials chemistry, and electrochemistry, and, more specifically, renewable energy and the environment. He has published 127 research articles in international journals of repute and eighteen chapters in books published by renowned international publishers. He has also edited thirty-nine books. Dr. Inamuddin is a member of various journal editorial boards and is an associate editor for journals such as Environmental Chemistry Letter, Applied Water Science, Euro-Mediterranean Journal for Environmental Integration, and Springer-Nature. He is also an editor for the Eurasian Journal of Analytical Chemistry.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}},coeditorTwo:{id:"293058",title:"Dr.",name:"Anish",middleName:null,surname:"Khan",slug:"anish-khan",fullName:"Anish Khan",profilePictureURL:"https://mts.intechopen.com/storage/users/293058/images/system/293058.JPG",biography:"Dr. Anish Khan is an assistant professor at the Center of Excellence for Advanced Materials Research (CEAMR), Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. He obtained a Ph.D. from Aligarh Muslim University, India, in 2010, and a postdoctoral degree in Electroanalytical Chemistry from the School of Chemical Sciences, University Sains Malaysia (USM), in 2010. Dr. Khan works in the fields of sensors, polymer composites, and organic-inorganic electrically conducting nanocomposites. He has more than 250 research articles, 80 book chapters, 50 edited books, and more than 20 international conferences/workshops to his credit. He is an editorial board member for several international journals.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}},coeditorThree:{id:"198266",title:"Dr.",name:"Abdullah Mohammed",middleName:"Ahmed",surname:"Asiri",slug:"abdullah-mohammed-asiri",fullName:"Abdullah Mohammed Asiri",profilePictureURL:"https://mts.intechopen.com/storage/users/198266/images/system/198266.png",biography:"Prof. Abdullah Mohammed Ahmed Asiri is a professor and chairman of the Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He is also the director of the university’s Center of Excellence for Advanced Materials Research (CEAMR). He obtained a Ph.D. in tribochromic compounds and their applications from the University of Wales College, Cardiff, UK, in 1995. He is the director of the Education Affair Unit–Deanship of Community Services. Dr. Asiri is a member of the advisory committee for advancing materials, National Technology Plan, King Abdul Aziz City of Science and Technology, Riyadh, Saudi Arabia. He is an editorial board member of the Journal of Saudi Chemical Society, Journal of King Abdul Aziz University, Pigment and Resin Technology Journal, Organic Chemistry Insights, Libertas Academica, and Recent Patents on Materials Science. Dr. Asiri holds membership in several national and international societies and professional bodies.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}},coeditorFour:null,coeditorFive:null,topics:[{id:"489",title:"Bioinorganic Chemistry",slug:"bioinorganic-chemistry"}],chapters:[{id:"69688",title:"Introductory Chapter: Fundamental Discussion of Selenium Effect",doi:"10.5772/intechopen.89833",slug:"introductory-chapter-fundamental-discussion-of-selenium-effect",totalDownloads:659,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Mohammed Muzibur Rahman",downloadPdfUrl:"/chapter/pdf-download/69688",previewPdfUrl:"/chapter/pdf-preview/69688",authors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],corrections:null},{id:"68863",title:"The Importance of Selenium in Children’s Health and Reproduction",doi:"10.5772/intechopen.88864",slug:"the-importance-of-selenium-in-children-s-health-and-reproduction",totalDownloads:784,totalCrossrefCites:1,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The authors report selenium deficiency in pregnant women, which can lead to an increase in the frequency and severity of early and late gestosis, fetal hypotrophy, hypoxia, and increased risk of miscarriage. The provision of selenium in children depends on the degree of maturity and physical development, decreases with fetal hypotrophy, prematurity, artificial feeding, and hypoxia. The content of selenium in breast milk of women who gave birth prematurely, contains selenium three times less than in normal childbirth, which contributes to a high risk of alimentary-dependent conditions in premature infants.",signatures:"O.A. Senkevich and Y.G. Koval’skiy",downloadPdfUrl:"/chapter/pdf-download/68863",previewPdfUrl:"/chapter/pdf-preview/68863",authors:[{id:"271192",title:"Prof.",name:"Ольга",surname:"Сенькевич",slug:"olga-senkevich",fullName:"Ольга Сенькевич"},{id:"309066",title:"Prof.",name:"Yuriy",surname:"Koval'Skiy",slug:"yuriy-koval'skiy",fullName:"Yuriy Koval'Skiy"}],corrections:null},{id:"70351",title:"Uptake, Metabolism and Toxicity of Selenium in Tropical Plants",doi:"10.5772/intechopen.90295",slug:"uptake-metabolism-and-toxicity-of-selenium-in-tropical-plants",totalDownloads:729,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Selenium is a mineral element that is essential for both animal and humans and can also serve as an environmental toxicant. A narrow margin exists between an ideal and toxic intake of selenium. It is a useful microelement existing in minute amounts in animals, plants, microorganisms and humans. Although it is beneficial to both animals and humans as an antioxidant, it can be toxic at high concentrations as a result of it competing and replacing sulfur in amino acids leading to inappropriate folding of protein and eventually creating a nonfunctional protein and enzymes. Selenium exists in organic forms as SeMet and SeCys and inorganic forms as selenide, selenite and selenite in the environment. It is translocated in plants via the sulfate transporters in the plasma membrane of the plant root. Its translocation and distribution however depends on the plant species, their different developmental phases, forms, concentration and other physiological conditions like pH. Inorganic selenium is first converted to selenite via the action of two different enzymes (ATP sulfurylase and APS reductase), selenite is further converted to selenide by sulfite reductase. Selenide eventually couples with O-acetyl serine via the action of cysteine synthase to form SeCys. SeCys can either be methylated to methyl-SeCys through the action of selenocysteine methyltransferase or to elemental selenium via SeCys lyase or converted by a series of enzymes to selenomethionine. Selenium toxicity or Selenosis can occur when the optimal concentration of selenium is exceeded. Two major mechanism of selenium toxicity exists; either by induction of oxidative stress or malformation of selenoproteins. Selenium uptake, metabolism and toxicity in tropical plants are hereby discussed in this chapter.",signatures:"Abiodun Humphrey Adebayo, Omolara Faith Yakubu and Osarobo Bakare-Akpata",downloadPdfUrl:"/chapter/pdf-download/70351",previewPdfUrl:"/chapter/pdf-preview/70351",authors:[{id:"310477",title:"Prof.",name:"Abiodun",surname:"Adebayo",slug:"abiodun-adebayo",fullName:"Abiodun Adebayo"},{id:"310705",title:"Dr.",name:"Omolara",surname:"Yakubu",slug:"omolara-yakubu",fullName:"Omolara Yakubu"},{id:"314334",title:"Ms.",name:"Osarobo",surname:"Bakare-Akpata",slug:"osarobo-bakare-akpata",fullName:"Osarobo Bakare-Akpata"}],corrections:null},{id:"69389",title:"Selenium Fertilization in Tropical Pastures",doi:"10.5772/intechopen.89423",slug:"selenium-fertilization-in-tropical-pastures",totalDownloads:537,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Brazil is one of the largest meat producers. Meat along with other animal products have been responsible for its larger contribution as source of selenium (Se) for human. However, Se deficiency remains a concern because researches have indicated that this nutrient is found in low levels in Brazilian diet. Cattle in Brazil are fed basically from pasture, but there are strong evidences that soils contain low availability of Se; consequently plants and animals incorporate low Se levels. Pastures, Se fertilized, bring benefits to nutrition and health of animal consequently to humans already known in some countries. In contrast, Se fertilization on tropical weathered soils and tropical forages is little known. However, Se management as fertilizer in tropical environments requires researches involving field experiments, especially with animals, for establishing of safe and effective Se recommendations as fertilizer due to the Se toxicity potential and complexity in system of soil-plant-animal-human.",signatures:"Letícia de Abreu Faria, Pedro Henrique de Cerqueira Luz and Adibe Luiz Abdalla",downloadPdfUrl:"/chapter/pdf-download/69389",previewPdfUrl:"/chapter/pdf-preview/69389",authors:[{id:"308474",title:"Dr.",name:"Letícia",surname:"Faria",slug:"leticia-faria",fullName:"Letícia Faria"},{id:"309336",title:"Dr.",name:"Pedro Henrique De Cerqueira",surname:"Luz",slug:"pedro-henrique-de-cerqueira-luz",fullName:"Pedro Henrique De Cerqueira Luz"},{id:"310823",title:"Dr.",name:"Adibe",surname:"Luiz Abdala",slug:"adibe-luiz-abdala",fullName:"Adibe Luiz Abdala"}],corrections:null},{id:"68081",title:"Chromatographic Analysis of Selenium Species",doi:"10.5772/intechopen.87053",slug:"chromatographic-analysis-of-selenium-species",totalDownloads:800,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Selenium is an important element in environmental and living organisms that is being essential in very narrow concentration range, while deficiency or toxicity occurs outside this range. However, its toxicity depends not only on its dose but also on its chemical form. In environmental samples, selenium can exist in inorganic forms (as elemental selenium, metal selenides, selenite, or selenate anions) and as organic species with direct C-Se bonds (methylated compounds, selenoaminoacids, and selenoproteins). Thus, the development of reliable techniques to study the speciation of selenium in environmental samples is necessary. The main purpose of this chapter is to provide an update on the recent literature concerning the strategies for selenium speciation in environmental samples. Liquid chromatography coupled with sensitive detector is a commonly used technique for selenium separation. Gas chromatography can also be applied for such purpose; however derivatization step is usually required before analysis. Direct determination of selenium species at the concentration levels present in natural samples is very often difficult or even impossible. For this, several preconcentration/separation procedures for selenium have been proposed, including coprecipitation, extraction into an organic solvent, or application of solid sorbents.",signatures:"Aleksandra Sentkowska",downloadPdfUrl:"/chapter/pdf-download/68081",previewPdfUrl:"/chapter/pdf-preview/68081",authors:[{id:"299167",title:"Dr.",name:"Aleksandra",surname:"Sentkowska",slug:"aleksandra-sentkowska",fullName:"Aleksandra Sentkowska"}],corrections:null},{id:"68862",title:"Selenium in the Prevention and Treatment of Hepatocellular Carcinoma: From Biomedical Investigation to Clinical Application",doi:"10.5772/intechopen.88960",slug:"selenium-in-the-prevention-and-treatment-of-hepatocellular-carcinoma-from-biomedical-investigation-t",totalDownloads:802,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Selenium is a micronutrient that had been suggested to reduce the risk of cancer. Hepatocellular carcinoma (HCC), a prevalent disease and one of the most lethal cancers in the world, awaits new alternative treatment strategies to improve patients’ survival. As an essential trace element, selenium has been studied for its anticancer properties in both oxidative stress and inflammatory-related mechanisms that may contribute to HCC growth and metastasis. In recent decades, increasing studies have investigated the potential role of selenium in liver cancer involving several major cancer-associated signaling pathways, metabolic pathways, and antioxidant defense systems both in vitro and in preclinical models. It was also observed that there was an increase in the trend of development of novel selenium nanoparticles and selenium-containing inhibitors aiming to improve the therapeutic efficacy and relative potency of selenium. However, controversies remain with whether a relationship exists between serum selenium level and HCC risk. This chapter aims to summarize the multi-target and multi-pathway in vitro and in vivo pharmacological effects of selenium in HCC, to provide a more comprehensive view and to highlight the recently discovered molecular mechanisms We hope this chapter could outline the correlation of selenium level and the risk of HCC in patients and discuss the clinical application of selenium in HCC prevention and treatment.",signatures:"Chien-Shan Cheng, Ning Wang and Yibin Feng",downloadPdfUrl:"/chapter/pdf-download/68862",previewPdfUrl:"/chapter/pdf-preview/68862",authors:[{id:"14428",title:"Prof.",name:"Yibin",surname:"Feng",slug:"yibin-feng",fullName:"Yibin Feng"},{id:"175059",title:"Dr.",name:"Ning",surname:"Wang",slug:"ning-wang",fullName:"Ning Wang"},{id:"310035",title:"Ms.",name:"Chien-Shan",surname:"Cheng",slug:"chien-shan-cheng",fullName:"Chien-Shan Cheng"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"861",title:"Nanomaterials",subtitle:null,isOpenForSubmission:!1,hash:"f32b97a9aa541939cb212373d471d477",slug:"nanomaterials",bookSignature:"Mohammed Muzibur Rahman",coverURL:"https://cdn.intechopen.com/books/images_new/861.jpg",editedByType:"Edited by",editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5403",title:"Advances in Colloid Science",subtitle:null,isOpenForSubmission:!1,hash:"38413a6aefb978b024eac803fba6c354",slug:"advances-in-colloid-science",bookSignature:"Mohammed Muzibur Rahman and Abdullah Mohamed Asiri",coverURL:"https://cdn.intechopen.com/books/images_new/5403.jpg",editedByType:"Edited by",editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7230",title:"Recent Advances in Ionic Liquids",subtitle:null,isOpenForSubmission:!1,hash:"cebbba5d7b2b6c41fafebde32f87f90b",slug:"recent-advances-in-ionic-liquids",bookSignature:"Mohammed Muzibur Rahman",coverURL:"https://cdn.intechopen.com/books/images_new/7230.jpg",editedByType:"Edited by",editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5308",title:"Nanofiber Research",subtitle:"Reaching New Heights",isOpenForSubmission:!1,hash:"e5d2ad58b1840ec81e587914d52f5e0b",slug:"nanofiber-research-reaching-new-heights",bookSignature:"Mohammed Muzibur Rahman and Abdullah M. 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Uncertainty evaluation is essential to guarantee the metrological traceability of measurement results and to ensure that they are accurate and reliable. In addition, measurement uncertainty must be considered whenever a decision has to be taken based on measurement results, such as in accept/reject or pass/fail processes.
\nConsidering the context of globalization of markets, it is necessary to adopt a universal procedure for evaluating uncertainty of measurements, in view of the need for comparability of results between nations and for mutual recognition in metrology. As an example, laboratories accredited under the ISO/IEC 17025:2017 standard [1] need to demonstrate their technical competence and the ability to properly operate their management systems, and so they are required to evaluate the uncertainty for their measurement results.
\nIn addition, the use of uncertainty evaluation methods as a tool for technical management of measurement processes is extremely important to reduce, for example, the large number of losses that occurs in the industry, which can be highly significant in relation to the gross domestic product (GDP) of some countries. One of the probable causes of the waste can be attributed to instruments whose accuracy is inadequate to the tolerance of a certain measurement process.
\nIn this chapter, detailed steps for uncertainty evaluation are given.
\nIn order to harmonize the uncertainty evaluation process for every laboratory, the
Evaluation of uncertainty, as presented by the JCGM 100:2008, is based on the law of propagation of uncertainties (LPU). This methodology has been successfully applied for several years worldwide for a range of different measurement systems and is currently the most used procedure for uncertainty evaluation in metrology. However, since its twentieth anniversary in 2013, JCGM decided to revise it again [8, 9, 10]. In this new revision, uncertainty terms and concepts [11] will be aligned with the current International Vocabulary of Metrology (VIM) [12] and with the new GUM supplements [5, 6]. Aspects such as a new Bayesian approach, the redefinition of coverage intervals and the elimination of the Welch-Satterthwaite formula to evaluate the effective degrees of freedom will be covered [9]. In late 2014, a first draft of the newly revised version of the GUM was circulated among National Metrology Institutes. Remarkable changes were made that could affect the way laboratories deal with the measurement uncertainty results. This revision is still being discussed, and some information about it has also been released elsewhere [10].
\nIn the field of analytical chemistry, there is also another document worth mentioning that is the “Quantifying Uncertainty in Analytical Measurement” guide [13], produced by a joint EURACHEM/CITAC Measurement Uncertainty Working Group. This document was first published in 1995 and further revised in 2000 [14]. This last edition had a widespread implementation and is among the most highly cited publications in chemical metrology area [14]. Recently, a new revised edition was published in 2012 with improved content and added information on developments in uncertainty evaluation [14]. This document basically presents the uncertainty evaluation process following the suggestions of the GUM, but also contains several examples in the analytical chemistry area.
\nThe following main steps summarize the methodology presented by the GUM.
\nIt must be clear to the analyst which quantity will be the final object of the measurement in question. This quantity is known as the measurand. In addition, it is important to identify all the variables that directly or indirectly influence the measurand. These variables are known as the input quantities. As an example, Eq. (1) shows a measurand \n
In this step, the measurement procedure should be modeled in order to have a functional relationship expressing the measurand as a result of all the input quantities. The measurand \n
The modeling step is critical for the uncertainty evaluation process as it defines how the input quantities impact the measurand. The better the model is defined, the better its representation of reality will be, including all the sources that impact the measurand on the uncertainty evaluation. The modeling process can be easily visualized by using a cause-effect diagram (Figure 1).
\nA cause-effect diagram representing the model from
A conceptual illustration of the experimental setup for a measurement of torque (
A simple model that describes this experiment can be expressed as follows:
\nwhere \n
This step is also of great importance. Here, uncertainties for all the input quantities are individually evaluated. The GUM classifies uncertainty sources as being of two main types: Type A, which usually originates from some statistical analysis, such as the standard deviation obtained in a repeatability study; and Type B, which is determined from any other source of information, such as a calibration certificate or deduced from personal experience.
\nType A uncertainties from repeatability studies are evaluated by the GUM as the standard deviation of the mean obtained from the repeated measurements. For example, if a set of \n
where \n
It is important to note that the evaluation of uncertainties of Type B input sources must be based on careful analysis of observations or in an accurate scientific judgment, using all available information about the measurement procedure. This uncertainty type is generally used when repeated experiments would not be possible, not available, or would be too costly or time-consuming. In this case, the GUM also suggests the use of two more types of statistical distributions: the uniform and the triangular distributions.
\nThe uniform distribution should be used when only a range of values are available, that is, an interval with the minimum and maximum values, and no detailed information about the probability of values within this interval is available. The standard uncertainty associated with such an interval is given by Eq. (6):
\nwhere
The triangular distribution can be used when there is a strong evidence that the most probable value lies in the middle of a given interval, but still without knowing exactly how this probability behave within the interval. In chemistry, for example, the uncertainty associated with the volume of a measuring flask could be evaluated by a triangular distribution. The standard uncertainty for a triangular distribution is given by Eq. (7):
\nwhere \n
Another common Type B source of uncertainty is due to calibration certificates, related to a standard or to a calibrated instrument. In this case, the standard uncertainty to be used is normally obtained by dividing the expanded uncertainty \n
Several good examples on how to treat some of the most common uncertainty sources can be found on the GUM [3], the EURACHEM/CITAC guide [13], and elsewhere [16].
\nIn addition, the balance used for the measurement has a certificate stating an expanded uncertainty for this range of mass of \n
In practice, one can imagine several more sources of uncertainty for this experiment, like, for example, the thermal dilatation of the arm as the room temperature changes. However, the objective here is not to exhaust all the possibilities, but instead to provide basic notions of how to implement the methodology of the GUM on a simple model.
\nThe GUM uncertainty approach is based on the law of propagation of uncertainties (LPU). This methodology encompasses a set of approximations to simplify the calculations and is valid for a range of simplistic models.
\nAccording to the LPU, the propagation of uncertainties is accomplished by expanding the measurand model in a Taylor series and simplifying the expression by considering only the first-order terms. This approximation is viable as uncertainties are very small numbers compared with the values of their corresponding quantities. In this way, the treatment of a model where the measurand \n
where \n
The partial derivatives of Eq. (11) are known as sensitivity coefficients and describe how the output estimate \n
Another important observation regarding the sensitivity coefficient occurs when the mathematical model that defines the measurand does not contemplate a given quantity, known as influence quantity. In this case, the determination of the sensitivity coefficient of the measurand in relation to the input quantity must be done experimentally. For example, biodiesel is susceptible to oxidation when exposed to air, and this oxidation process affects fuel quality. The oxidation time is determined by measuring the conductivity of an oil sample when inflated with air at a given flow rate. There are a number of influence quantities that impact the oxidation time of biodiesel such as temperature, air flow, conductivity, sample mass, and so on. In this case, the sensitivity coefficients for oxidation time with respect to each of these influence quantities are determined from an interpolation function obtained with experimental data. For example, Figure 3 presents the table and its resulting graph, which shows the model of the function that relates the oxidation time to the temperature of a biofuel sample (case study of the authors).
\nA table and a graph representing the variation of the oxidation time of a biofuel sample as a function of temperature.
It is important to note that the terms (not squared) of Eq. (12), that is, each sensitivity coefficient multiplied by its corresponding uncertainty, are known as uncertainty components. These components can be compared to each other as they are in the same units of the measurand. Figure 4 shows the comparison between the uncertainty components for the torque measurement model.
\nUncertainty component balance for the input quantities in the torque measurement model.
As can be noted, the dominant uncertainty component is due to the uncertainty associated with the measurement of the arm length, which was taken as the resolution of the non-calibrated ruler used in the measurement. This analysis shows to the analyst that, to reduce the final uncertainty and improve the measurement system, a calibrated ruler, with a better uncertainty, should be used. This represents the importance of the GUM as a management tool to the measurement process.
\nThe Kragten method is an approximation that facilitates the calculation of the combined uncertainty using finite differences in place of the derivatives [13]. This approximation is valid when the uncertainties of the inputs are relatively small compared to the respective values of the input quantities, generating discrepancies in the final result in relation to the LPU that occur in decimals that can be ignored.
\nAssuming a measurand \n
The value of the measurand \n
Thus, the combined standard uncertainty of \n
or by Eq. (20), if there are correlated uncertainties
\nwhere \n
The result provided by Eqs. (10) and (11) corresponds to an interval that contains only one standard deviation (or approx. 68.2% of the measurements for a normal distribution). In order to have a better coverage probability for the result, the GUM approach expands this interval by assuming that the measurand follows the behavior of a Student’s
where \n
The effective degrees of freedom is used to obtain a coverage factor \n
Using
One of the most valuable tools for the metrologist is the calibration curve. It is widely used in measurement systems on which one cannot directly obtain the property value to be measured of an object. Instead, a response from the system is measured. In this way, a calibration curve is used to correlate the response from the system with well-known property values, usually calibration standards (see Figure 5).
\nAn example of a linear calibration curve for atomic absorption spectroscopy: the absorption signals (instrument responses) are plotted against the concentrations for a specific analyte.
With a calibration curve in hands, the property value for a new unknown sample can be directly determined by using the equation for the fitted curve, which is usually adjusted by a linear regression. However, the calibration curve contains errors due to the lack of fit for the experimental data, causing an uncertainty source to arise. Thus, when evaluating the uncertainty for a predicted property value of \n
where \n
For Eq. (26), \n
The uncertainties for \n
where \n
where \n
Indication ( | \nReference value ( | \n
---|---|
20 | \n20.3 | \n
21 | \n21.3 | \n
22 | \n22.2 | \n
23 | \n23.1 | \n
24 | \n24.2 | \n
25 | \n25.1 | \n
27 | \n27.0 | \n
Values of the calibration certificate of a thermometer.
For the data shown in Table 1, the calibration curve of the thermometer is expressed by \n
Using Eqs. (28)–(31), it is possible to calculate the values of Table 2 that shows the statistical data for the thermometer calibration curve.
\nData | \nValue | \nUnit | \n
---|---|---|
\n\n | \n0.0024 | \n°C2 | \n
\n\n | \n0.1943 | \n°C | \n
\n\n | \n0.0084 | \n\n |
\n\n | \n−0.995 | \n\n |
Statistical data for the calibration curve of a thermometer.
Considering that there is no uncertainty for the observed point \n
Another frequently used expression for the standard uncertainty of the predicted value \n
where \n
However, Hibbert [19] suggests that if the standard deviation of the indications is known from consistent data, \n
where \n
The methodology presented in the GUM can also be used to evaluate the uncertainty in the calibration of a measuring instrument. Following the steps of the GUM, the measurand for the model used in the calibration must be defined by the quantity that evaluates the systematic error of an instrument over its entire measurement range. Thus, Eq. (36) can be generally used for the evaluation of uncertainty in a calibration process:
\nwhere \n
From Eq. (36), a basic cause-and-effect diagram can be assembled for the calibration uncertainty assessment of an instrument, as shown in Figure 6.
\nA general cause-and-effect diagram for the calibration of an instrument.
The sources of uncertainty in this case involve the repeatability of indicated values, the resolution of the instrument in calibration, and the certificate of calibration of the reference values. Thus, an evaluation of the uncertainty about the systematic error should be done for each nominal value of the instrument in calibration. The combined standard uncertainties \n
where \n
The final calibration result can then be presented according to Table 3. In addition, correction values or systematic errors can also be reported.
\nRange | \nIndicated value | \nReference value | \nExpanded uncertainty | \nCoverage factor | \n
---|---|---|---|---|
Range 1 | \n||||
Range 2 | \n||||
… | \n… | \n… | \n… | \n… | \n
Range | \n
A typical format for the result of calibration of an instrument.
This section presents the limitations of the GUM and shows an alternative methodology based on the propagation of distributions that overcome those limitations. For further details, please refer to the authors’ publication that addresses the use of the Monte Carlo methodology applied to uncertainty in measurement [15] or to the JCGM 101:2008 guide [5]. Also, in the field of analytical chemistry, the latest version of EURACHEM/CITAC guide (2012) was updated with procedures to use Monte Carlo simulations [13].
\nAs mentioned earlier, the approach to evaluate measurement uncertainties using the LPU as presented by the GUM is based on some approximations that are not valid for every measurement model [5, 20, 21, 22]. These approximations comprise (1) the linearization of the measurement model made by the truncation of the Taylor series, (2) the use of a
The limitations and approximations of the LPU are overcome when using a methodology that relies on the propagation of distributions. This methodology carries more information than the simple propagation of uncertainties and generally provides results closer to reality. It is described in detail by the JCGM 101:2008 guide (Evaluation of measurement data—Supplement 1 to the “Guide to the expression of uncertainty in measurement”—propagation of distributions using a Monte Carlo method) [5], providing basic guidelines for using Monte Carlo numerical simulations for the propagation of distributions in metrology. This method provides reliable results for a wider range of measurement models as compared to the GUM approach and is presented as a fast and robust alternative method for cases where the GUM approach does not present good results.
\nThe propagation of distributions as presented by the JCGM 101:2008 involves the convolution of the probability distributions for the input sources of uncertainty through the measurement model to generate a distribution for the output (the measurand). In this process, no information is lost due to approximations, and the result is much more consistent with reality.
\nThe main steps of this methodology are similar to those presented in the GUM. The measurand must be defined as a function of the input quantities through a model. Then, for each input, a probability density function (PDF) must be assigned. In this step, the concept of maximum entropy used in the Bayesian statistics should be used to assign a PDF that does not contain more information than that which is known by the analyst. A number of Monte Carlo trials are then chosen and the simulation can be set to run.
\nResults are expressed in terms of the average value for the output PDF, its standard deviation, and the end points that cover a chosen probability \n
For the calibration component, the supplement 1 recommends the use of a normal distribution if the number of degrees of freedom is not available. In this case, the mass value of 35.7653 kg is taken as the mean and a standard deviation of \n
Table 4 resumes the input information for the simulation, which was executed for \n
Uncertainty source | \nType | \nPDF parameters | \n|
---|---|---|---|
Mass (repeatability) | \nA | \nMean: 35.7653 kg; scale: 9.49 x 10−5 kg; degrees of freedom: 9 | \n|
Mass (certificate) | \nB | \nNormal | \nMean: 0 kg; standard deviation: 0.00005 kg | \n
Local gravity | \nB | \nNormal | \nMean: 9.80665 m/s2; standard deviation: 0.00001 m/s2 | \n
Arm length | \nB | \nUniform | \nMinimum: 1999.5 mm; maximum: 2000.5 mm | \n
A summary of sources of uncertainty and their associated distributions for the measurement of torque.
Output distribution resulting from the Monte Carlo simulation for the evaluation of uncertainty of measurement of torque.
Table 5 summarizes the statistical data of the output distribution, including the upper and lower limits of a probabilistically symmetric range for a 95% coverage probability.
\nStatistical data | \nValue (N m) | \n
---|---|
Mean | \n667.970 | \n
Standard deviation | \n0.096 | \n
Lower limit for | \n667.812 | \n
Upper limit for | \n668.129 | \n
A summary of the statistical data for the output distribution for the measurement of torque.
Measurement uncertainty and metrological traceability are interdependent concepts. The evaluation of uncertainties of measurement results is essential to ensure that they are reliable and comparable. Moreover, the process that involves the modeling of measurement systems and evaluation of their uncertainties is of great importance for the metrologist as it constitutes a tool for the management of the measurement laboratory, since it can indicate exactly where to invest to get better, more qualified results.
\nThe GUM and the application of the LPU continue to be the most used and widespread methodology for bottom-up uncertainty evaluation in metrology. It is adopted worldwide and provides a strong base for comparability of measurement results between laboratories. On the other hand, a new version for the GUM is currently under revision. This version should be aligned with its supplements in a more harmonized way, incorporating concepts from Bayesian statistics and resolving some inconsistencies. As a consequence, if the mentioned distribution-free coverage intervals are maintained, results for the expanded uncertainty will be greatly overestimated compared to the current version of the GUM.
\nIn this way, the best alternative for a more realistic and lean uncertainty assessment would be through a numerical simulation using the Monte Carlo method, which should lead to a smaller and more reliable uncertainty result.
\nMalnutrition is commonly referred to as under-nutrition [1]. Stunting, wasting, and being underweight in children under the age of five are all signs of malnutrition [2]. Malnutrition refers to any shortage, surplus, or volatility in energy and/or nutritional demands, and includes both under and over-nutrition [3, 4]. 165 million children under the age of five suffer from malnutrition across the world. India (46.6 million), Nigeria (13.9 million), and Pakistan (10.7 million) have the world’s least stunted children, according to the 2018 Global Nutrition Report [5]. Malnutrition is responsible for at least half of all child deaths globally [6, 7]. Children’s malnutrition is mostly a problem in developing and disadvantaged countries [8]. The leading cause of sickness and death among children is malnutrition [9]. Malnutrition is among the world’s most serious health problems, affecting around 2 billion people. Malnutrition in all forms (appetite, undernourishment, vitamin deficiencies, overweight, and obesity) appears to be a severe concern for both emerging and industrialized countries, according to the World Committee on Food Security. Hunger may be characterized in many different ways, including individual experiences and behavioral reactions in the home, food shortages, and national food balance sheets [10]. Approximately 151 million children under the age of five are stunted, over 50 million are wasted, and nearly 17 million are seriously wasted, according to UNICEF/WHO/World Bank Group estimates [11, 12]. Although the total rate of stunting in Asia has decreased from 38 percent to 23 percent between 2000 and 2017, it is still the highest [13].
Pakistan is now experiencing a complicated malnutrition problem that affects people of all ages, especially newborns, children, adolescents, and pregnant and nursing mothers. As per UN Worldometer statistics, Pakistan’s population is now predicted to be about 219.1 million, with a potential increase to >260 million by 2030 [14]. Malnutrition is predicted to cost emerging nations between 2 and 3% of their GDP (GDP). Malnutrition is estimated to cost a person one-tenth of their lifetime wages [15]. Pakistan has a high rate of malnutrition. As a result, nearly a quarter of the population of a low-middle-income, fifth nation is unable to meet an adult’s dietary needs (2350 calories per day) [16, 17, 18]. According to a recent global report on child malnutrition, The majority of households in low and middle-income countries are facing dual-faced malnutrition as a result of a dietary shift, which is defined as a home with an obese mother and an undernourished child. On the other hand, stunting is declining relatively slow, whereas excess weight continues to rise globally [19]. As a result, while establishing policies, programs, and interventions to prevent undernutrition, food insecurity and dietary variety should be considered [20].
Stunting develops in children as a result of a regular caloric intake and nutrients that are insufficient to meet their needs. A lack of linear development, or a modest stature or height in one’s age, is referred to as stunting. This is evaluated by dividing a child’s height for his or her age to either a comparison group of well-fed and healthy children (Z score of 2 or less). Stunting refers to excess or inequality in a person’s energy or calorie consumption that is linked to stunted physical and psychological development [21]. Stunting is associated with the phrase “small for gestational age” (SGA) globally [22]. If pregnant women’s nutritional demands are not addressed sufficiently, they might not be able to provide the fetus with the nourishment it needs during pregnancy. Malnourishment in pregnancy is a big issue in Pakistan since it can inhibit a baby’s development and raise the risk of certain diseases later in life [23]. According to the United Nations Children’s Fund, almost 10 million Pakistani children are stunted (UNICEF). For the first 6 months of their lives, just 38% of newborns are exclusively breastfed. As a result, more than half of children under the age of five are deficient in vitamin A, 40% are zinc and vitamin D deficient, and 62% are anemic. In Pakistan, 4 out of every 10 children under the age of five are stunted, with 40.2 percent wasting and 17.7% stunting. According to the 2018 national nutritional survey, more than one-third of children (28.9%) are underweight, with a high prevalence of overweight (9.5%) in the same age range shown in Figure 1.
National nutrition survey malnutrition report.
The nutritional challenges of their children are linked to the moms’ diet and wellness during adolescence, gestation, and breastfeeding periods. As a result, expectant moms must receive appropriate and balanced nourishment. Maternal micronutrient supplementation (MMS) during pregnancy improved gestation, birth weight, and fetal development in Tanzanian infants, as evidenced by their 6-week mortality rate, which was only quantifiable in females but not males newborns [24]. Due to compromised immune systems, malnutrition and infection combined to raise the risk of childhood morbidity and death. More than half of all children under the age of five are expected to die from malnutrition. Immunological changes have been associated with decreased intestinal activities, the inadequate release of protective material from exocrine glands, and decreased participation of the signaling pathway in serum proteins, albeit the underlying processes are unknown [25]. Children’s intrinsic and innate immune responses are also influenced by protein and micronutrient deficits [26]. In children, changes in the gut microbiota can limit growth, disrupt inflammatory immunological processes, reduce functional brain connections, and also delay psychomotor and intellectual abilities [27, 28].
Other geriatric syndromes have been associated with depressive symptoms and malnutrition, both of which are modifiable risk factors for 30-day readmission in hospitalized older people [29]. The prevalence of malnutrition, as measured by the CONUT score, was high in older people undergoing elective surgery for colon cancer patients. Malnutrition has been related to a prolonged stay in the hospital as well as a higher chance of negative outcomes. Both death and readmissions to the intensive care unit are on the rise. CONUT is a quick and easy nutritional screening test that has previously been used to assess nutritional status in people who have had CRC surgery. A longer hospital stay is linked to a lower nutritional state. It’s more likely that difficulties may occur. as well as a higher mortality risk [30]. Sarcopenia, cachexia, diminished sensory function, and alterations in the gastrointestinal system are some of the factors linked to old age [31].
In South Asian nations, the primary factors of malnutrition and stunting are remarkably similar. The key categories include food insecurity and insufficient nutritional intake, social status and inequality, maternity and environmental factors, poverty, and water sanitation hygiene.
Poverty and food insecurity are the two most persistent and major variables that cause stunting. Food insecurity affects children’s nutrition, growth, and cognition and is a serious problem in developing nations. Food insecurity and diet variation should be considered while establishing strategies, plans, and interventions to address the problem of undernutrition [20]. The potential for economic growth of a country can impact food insecurity and, subsequently, the frequency of child stunting [32]. In Pakistani children, food insecurity is a major contributor to their low nutritional condition. In Pakistan, about two-thirds of families with nearly 80% of children lack adequate access to good and nutritional foods [33]. Insufficient diet, anemia, and nutrient deficits in pregnant mothers have been linked with lower childbirth weights in Pakistan. Even though Pakistan is a significant producer of rice and wheat becoming a food supply state, the nation’s economic insecurity has exacerbated the nutritional inequality among children and babies. According to the Pakistan Economic Survey 2018–2019, Pakistan’s overall food output and accessibility to basic food items are sufficient to meet the population’s nutritional needs [34].
According to the Journal of the American Dietetic Association 3, in 2025, the supply of calories from key food groups per person would climb to 2530 calories. As per the Pakistan Cost of Diet Analysis, 67% of Pakistani families cannot afford a scientifically appropriate meal, while around 5% cannot afford a diet that fulfills even the necessities of energy needs [35]. Despite rising per capita wealth, increased food production and accessibility, and better intakes of gross energy (calories from food), Pakistan’s current child stunting incidence is 40.2%. Nevertheless, over 60% of the people themselves are affected by food insecurity, with the lowest and perhaps most susceptible individuals in particular unable to buy sufficient healthy food [36]. Despite this, little is known about the non-nutritional repercussions of food insecurity, such as its implications on brain development and cognitive impairments, especially in developing countries [37]. The likelihood of baby undernourishment has also been connected to poor maternal mental health. Women with prenatal indicators of distress who lived in rural parts of Pakistan, and they had smaller amounts, larger family debts, and were food insecure, exhibited severe depression than women in high-income nations [38]. Young children are going through a phase of rapid growth and development, which necessitates more energy consumption. Humans and caretakers, on the other hand, meet their nutritional and dietary requirements. As a result, they are more likely to become malnourished [39]. Long-term exposure to natural disasters like landslides causes a decrease in the food supply, a lack of access to safe and nutritious food, a decrease in the quantity and quality of food consumed, and a lack of access to health, safe water, and sanitation facilities, all of which contribute to child malnutrition [40]. Long-term exposure to natural disasters, such as landslides, causes a decrease in the food supply, a lack of access to safe and nutritious food, a decrease in the quantity and quality of food consumed, and a lack of access to health, safe water, and sanitation facilities, all of which contribute to child malnutrition [41].
There is a strong relationship between several indicators of socioeconomic status (SES) and child stunting in low- and middle-income countries (LMIC). Children’s stunting is said to be impacted by socioeconomic inequity. Children in rural regions of the Democratic Republic of the Congo (DRC) were found to have a greater frequency of stunting than those in city environments. Boy stunting was much higher than girl stunting, especially among boys from low-income families. Breastfeeding, along with other nutrition treatments, must be given prompt attention to prevent stunting, they said [42]. Parents’ educational levels, particularly mothers’, mothers’ health and nutritional status during pregnancy and lactation, children’s vaccinations, family income level, and the current system were all socioeconomic factors affecting the nutritional health of children under the age of five in Nigeria [43, 44].
Stunting and thinness in Pakistani primary school kids (5–12 years) in Lahore, Pakistan, were studied for frequency and socioeconomic determinants. Researchers discovered that 8% of children were stunted and 10% were underweight, with no gender differences. Both boys and girls showed signs of stunting as they grew older, but only males were skinny. Stunting and thinness were found to be influenced by age, socioeconomic status, parental education, the number of siblings, overcrowding, and living in a smoky environment. Children from poorer, less qualified families who lived in low-income neighborhoods and in cramped residences with a smoking culture were considerably more likely to be stunted and skinny. Programs aiming at the disadvantaged and socially marginalized should be prioritized [45]. Stunting, underweight, and waste were identified in 44.4%, 29.4%, and 10.7% of Pakistani children (0–59 months), respectively. Mothers of children were under the age of 18 at the time of marriage, resided in rural regions, and attended a maternity clinic at least 3 times during pregnancy had a low risk of being stunted. Underweight in children was strongly linked to the mother’s level of education, height, BMI, and birth weight. Investigators concluded that the majority of the variables that cause malnutrition in Pakistani children may be avoided [46]. A higher amount of income or wealth, on the other hand, has been linked to a lower incidence of malnutrition in children. As a consequence, Pakistani women’s empowerment can help improve people’s health, which is key for the country’s future progress [47]. Parents with a lower degree of education have a lower household income and are more likely to live in poverty. They spend less money on appropriate nutrition because of a shortage of food, basic health care services, and exposure to terrible living conditions and diseases, and their children are more prone to growth failure [48].
Many of us associate poverty with pictures of starvation or children dying from avoidable diseases on television from the poor world [49, 50]. Poverty is a multifaceted issue in Pakistan. It is firmly embedded in the social, economic, and political systems of the country. The lack of good economic and political governance is the greatest obstacle to poverty reduction. Poverty was once associated with the severe types of malnutrition, particularly in children, that were common during times of famine and starvation. As indicated in Figure 2, the World Bank utilized the lower-middle-income poverty rate ($3.2 per day) to predict that Pakistan’s poverty rate stood at 39.3% in 2020–2021, is expected to continue at 39.2% in 2021–2022, and may drop to 37.9% by 2022–2023. Impoverished individuals are more susceptible to natural dangers (lack of sanitation, inadequate food, crime, and natural disasters), are far less aware of the benefits of good health, and get less access to quality health care. As a result, individuals seem to be more prone to disease and disability [51]. When girls reach reproductive age, they are more likely to give birth to low-birth-weight babies, who have a worse chance of survival than typical babies. Undernutrition is one of the most frequent diseases, the major cause of inadequate healthy development, and by far the most important component inhibiting a country’s progress [52].
Poverty rate from 2020 to 2023.
Malnutrition and stunting in children are generally induced by several factors, namely maternal health, ecological and home circumstances, poverty, socioeconomic disparities, low birth weight, dirty water, sanitation, proper hygiene, infections, and diarrhea [53, 54]. Gastrointestinal tract damage, immune suppression, including liver illness across both mothers and infants, as well as stunting in children, are all linked to aflatoxin and mycotoxin exposure from contaminated food [55]. Children who grow up in agricultural areas tend to have development problems throughout pregnancy, childhood, and adolescence [56]. The use of polluted water and the early introduction of supplemental feeding raises the risk of infections and water-borne illnesses including diarrhea and cholera, which impairs children’s food intake and nutrient utilization, causing stunting and wasting [57].
Poverty, poor sanitary conditions, and dirty water are the causative factors of child retardation in Pakistan, by a World Bank study. In Pakistan, open latrines are widely used, and the country is ranked third in the world for open defecation. Many nutritional and health issues are linked to open latrines, including intestinal infection and disease transmission. In Sindh, water and soil polluted with
Consequences of undernutrition.
Inadequate toilet facilities, inadequately treated water supplies, underprivileged healthcare access in remote regions, diarrhea and diseases, and food insecurity are among the most powerful factors of malnutrition and stunting in children in the developing world, according to the above-mentioned data.
The eradication of child malnutrition is crucial for people’s and society’s development. To achieve zero stunting, thorough nutritional therapy regimens must be implemented, particularly during the first 2 years of life. Multi-targeted intervention strategies with a focus on growth and anthropometric parameters are advised. Reduced child stunting is a crucial aim in reaching zero hunger, according to the Global Nutrition Targets for 2025 [62]. Scaling Up (SUN) The need to include stunting prevention in all future sustainable development efforts undertaken by member nations is highlighted by nutrition. Poor nursing habits and dietary deficiencies are thought to be the primary health issues of child stunting and bad health. Pakistan should promote supplementary feeding services for kids above the age of 6 months in addition to exclusive breastfeeding. To boost the nutritional impact of supplementary feeding habits and enhance children’s nutritional status, recommendations on their entry timing and frequency must be created and executed. It is necessary to develop and deliver suitable, low-cost fortified supplemental nutritious meals that are compatible with unique cultural foods, especially to homes at risk of potential poverty. According to the Global Alliance for Improved Nutrition, the leading causes of stunting in children are premature marriages and breastfeeding females more than boys. Boys are often given more food than girls, resulting in stunting and malnutrition in the female population. Not only are they unable to compete in many sectors with males, but malnourished moms are also unable to give birth to healthy kids [63].
Cooperative efforts to improve maternal nutrition and to eliminate child stunting, focusing on a variety of actions in areas such as agriculture, the environment, water, sanitation and hygiene, schooling, poverty alleviation, and social welfare, including the implementation of specific laws and policies. In Pakistan, malnutrition must be seen through an ideological lens, with implications for overall growth [64]. Cross strategies including all dietary and micronutrient techniques, to eliminate hunger and childhood stunting in Pakistan, strong political will must be formed and enforced. Deprivation, food shortages, bad sanitation, and hygienic practices, disease infection and vulnerability, maternity care, inequalities gender issues, poor diet patterns, and poor diets, as well as a high population growth rate, increasing urbanization, sensitivity to protection and wellbeing situations, or an absence of adequate ideological would all add to the quality of Pakistan’s dietary difficulties. According to the findings of a recent study, the majority of these variables are avoidable. On the other hand, integrated solutions for addressing these concerns should be developed in the framework of society’s academic and nutritional efforts [46]. Nutritional therapies can reduce stunting in general. Stunting is a significant danger for children living in urban slums. When creating dietary approaches to reduce low birth weight and child retardation in these kinds of circumstances, the diversity of such conditions in terms of physiological, social, and economic elements should be acknowledged [65]. It’s vital to create well-designed coordinated multistakeholder intervention strategies which use rational ways to fulfill the requirements of the most desperate individuals that are more prone to stunting as poverty [66]. As a result, appropriate recommendations initiatives should not only aim to reduce poverty, undernourishment, and climate difficulties but also improve and maintain a lengthy economic growth goal within the native culture. Because nutritional deficiencies, like iron and iodine, can harm children’s brain growth early in life, nutritional supplementation throughout pregnancy and childbirth is crucial for preventing cognitive deficits in infants and children [67]. Stunting and malnutrition can be reduced by food adjustments such as food supplements and micronutrient replacement, in combination with diet therapies [68, 69]. Niazi concluded that governmental and non-governmental institutions’ nutritious prevention efforts in Pakistan failed to deliver their aimed nutrition outcomes because they did not take an incorporated way of tackling the important principles of malnutrition such as lack of education, economic hardship, and sociocultural deprivation [70]. Every year, stunting among children causes Pakistan to lose 3% of its GDP. It is projected that every rupee spent to combat malnutrition will provide a return of 16 rupees. Well-fed children have a 33 percent higher chance of escaping poverty as adults [71, 72]. If adequate intervention programs and policies are adopted, Pakistan may likewise address the problem of malnutrition and stunting.
The link between economic advancement and improved nutrition can be either positive or negative. As per Wang and Taniguchi, good nutrition is beneficial to protracted income progress, although the benefits could be hidden by a current rapid population surge [73]. Headey investigated the effects of economic growth on dietary stunting in middle- and low-income nations across three continents. Increased food availability, poverty alleviation, and enhanced maternal and child health care, he claims, are all positives [74]. Nonetheless, even within areas, the nutritional impacts of economic expansion vary greatly. Thus according to conventional anthropometric measures, the incidence of malnutrition declined little in Sub-Saharan Africa despite decades of Economic growth faster than the overall. She also noted substantial differences in the distribution of child nutrition increases among demographic categories (such as urban vs. rural) [75].
Despite having multiple primary goals, nutrition-sensitive programs could have a similar impact on the underlying cause of child malnutrition as ‘micronutrient’ initiatives, not only as they are more diverse and larger in scale. Nursing and parental leave laws, free iron and folic acid for pregnant women, and vitamin A for early children are all examples of national programs [76]. Farming, healthcare, social welfare, early education, schooling, irrigation, and cleanliness are among the numerous sectors participating in nutrition-sensitive initiatives [77]. Conditional cash transfers are currently one of the most researched & examined types of planned action [76]. A sort of dietary approach provides financial assistance to individuals and households in need, often in exchange for a reciprocal activity like school attendance or completing a vaccination regimen. Although its main objective is to eliminate misery, such as in an emergency, there is increasing support that they have huge development influence [78].
Figure 4 depicts interventions that would reduce child malnutrition. Various organizations are collaborating with the UN to combat hunger, malnutrition, food insecurity, and other problems. WHO (World Food Organization), FAO (Food and Agriculture Organization), SUN (Scaling up Nutrition), UNHCR (United Nations High Commission for Refugees), and others are among these bodies. Each group devised its strategy to address the issue of malnutrition, which we will examine below. More Money for Nutrition and more nutrition for money (according to SUN Movement Strategy 2021–2025).
Bringing together the efforts of several groups
Providing food helps developing and underprivileged nations
Developed policies for displaced and refugee populations who are particularly prone to hunger
Checking and balancing the consequences for governance operations (according to SUN Movement Strategy 2021–2025)
Make wheat, which is Pakistan’s key food item, available to all of the country’s citizens.
Tracking Tools to assist nations in determining and monitoring their national objectives (FAO strategy)
Breastfeeding should be encouraged to avoid nutritional deficits in newborns.
Strategies for child malnutrition.
Malnutrition is one of the world’s most serious health problems, affecting about 2 billion people. UNICEF/WHO/World Bank Group estimates that 151 million children under the age of five are stunted, 50 million are wasted, and 17 million are severely wasted, according to UNICEF/WHO/World Bank Group estimates. Malnutrition is prevalent in Pakistan. Food insecurity, poverty, sanitation, hygiene, maternal and environmental variables, education, stunting, and other factors all contribute to malnutrition. This might be due to inadequate or ineffective intervention policies and programs, which have tended to focus on a single issue at a time rather than employing multi-sectoral methods to address the various factors that contribute to stunting. Cost-effective multitier interventions must be administered during the preconception, prenatal, and especially early postoperative periods to prevent malnutrition, stunting, and wasting in children. It is suggested that a comprehensive plan be devised and implemented to address the problem of malnutrition and stunting, which includes nutrition and WASH treatments, as well as activities to improve socioeconomic status. To guarantee that particular projects are created, performed, and sustained promptly, legislators, government and non-government agencies, other parties, and, most importantly, individual contributions and support are required.
We are grateful to the GCUF Digital Library for making the publication available to us.
There is no conflict of interest.
IntechOpen has always supported new and evolving ideas in scholarly publishing. We understand the community we serve, but to provide an even better service for our IntechOpen Authors and Academic Editors, we have partnered with leading companies and associations in the scientific field and beyond.
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Achilias",coverURL:"https://cdn.intechopen.com/books/images_new/10855.jpg",editedByType:"Edited by",editors:[{id:"95620",title:"Dr.",name:"Dimitris S.",middleName:null,surname:"Achilias",slug:"dimitris-s.-achilias",fullName:"Dimitris S. Achilias"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10843",title:"Persistent Organic Pollutants (POPs)",subtitle:"Monitoring, Impact and Treatment",isOpenForSubmission:!1,hash:"f5b1589f0a990b6114fef2dadc735dd9",slug:"persistent-organic-pollutants-pops-monitoring-impact-and-treatment",bookSignature:"Mohamed Nageeb Rashed",coverURL:"https://cdn.intechopen.com/books/images_new/10843.jpg",editedByType:"Edited by",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:218,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"29369",doi:"10.5772/32373",title:"Textile Organic Dyes – Characteristics, Polluting Effects and Separation/Elimination Procedures from Industrial Effluents – A Critical Overview",slug:"textile-organic-dyes-characteristics-polluting-effects-and-separation-elimination-procedures-from-in",totalDownloads:29434,totalCrossrefCites:125,totalDimensionsCites:312,abstract:null,book:{id:"872",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",title:"Organic Pollutants Ten Years After the Stockholm Convention",fullTitle:"Organic Pollutants Ten Years After the Stockholm Convention - Environmental and Analytical Update"},signatures:"Zaharia Carmen and Suteu Daniela",authors:[{id:"91196",title:"Prof.",name:"Carmen",middleName:null,surname:"Zaharia",slug:"carmen-zaharia",fullName:"Carmen Zaharia"},{id:"92084",title:"Dr.",name:"Daniela",middleName:null,surname:"Suteu",slug:"daniela-suteu",fullName:"Daniela Suteu"}]},{id:"42059",doi:"10.5772/54048",title:"Adsorption Technique for the Removal of Organic Pollutants from Water and Wastewater",slug:"adsorption-technique-for-the-removal-of-organic-pollutants-from-water-and-wastewater",totalDownloads:29962,totalCrossrefCites:51,totalDimensionsCites:210,abstract:null,book:{id:"3426",slug:"organic-pollutants-monitoring-risk-and-treatment",title:"Organic Pollutants",fullTitle:"Organic Pollutants - Monitoring, Risk and Treatment"},signatures:"Mohamed Nageeb Rashed",authors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}]},{id:"27305",doi:"10.5772/39363",title:"Water Stress in Plants: Causes, Effects and Responses",slug:"water-stress-in-plants-causes-effects-and-responses",totalDownloads:28463,totalCrossrefCites:68,totalDimensionsCites:166,abstract:null,book:{id:"911",slug:"water-stress",title:"Water Stress",fullTitle:"Water Stress"},signatures:"Seyed Y. S. Lisar, Rouhollah Motafakkerazad, Mosharraf M. Hossain and Ismail M. M. Rahman",authors:[{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman"}]},{id:"53211",doi:"10.5772/66416",title:"Biofloc Technology (BFT): A Tool for Water Quality Management in Aquaculture",slug:"biofloc-technology-bft-a-tool-for-water-quality-management-in-aquaculture",totalDownloads:16878,totalCrossrefCites:62,totalDimensionsCites:143,abstract:"Biofloc technology (BFT) is considered the new “blue revolution” in aquaculture. Such technique is based on in situ microorganism production which plays three major roles: (i) maintenance of water quality, by the uptake of nitrogen compounds generating in situ microbial protein; (ii) nutrition, increasing culture feasibility by reducing feed conversion ratio (FCR) and a decrease of feed costs; and (iii) competition with pathogens. The aggregates (bioflocs) are a rich protein-lipid natural source of food available in situ 24 hours per day due to a complex interaction between organic matter, physical substrate, and large range of microorganisms. This natural productivity plays an important role recycling nutrients and maintaining the water quality. The present chapter will discuss some insights of the role of microorganisms in BFT, main water quality parameters, the importance of the correct carbon-to-nitrogen ratio in the culture media, its calculations, and different types, as well as metagenomics of microorganisms and future perspectives.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Maurício Gustavo Coelho Emerenciano, Luis Rafael Martínez-\nCórdova, Marcel Martínez-Porchas and Anselmo Miranda-Baeza",authors:[{id:"146126",title:"Dr.",name:"Maurício Gustavo Coelho",middleName:null,surname:"Emerenciano",slug:"mauricio-gustavo-coelho-emerenciano",fullName:"Maurício Gustavo Coelho Emerenciano"},{id:"186970",title:"Prof.",name:"Marcel",middleName:null,surname:"Martínez-Porchas",slug:"marcel-martinez-porchas",fullName:"Marcel Martínez-Porchas"},{id:"186971",title:"Prof.",name:"Anselmo",middleName:null,surname:"Miranda-Baeza",slug:"anselmo-miranda-baeza",fullName:"Anselmo Miranda-Baeza"},{id:"195101",title:"Dr.",name:"Luis Rafael",middleName:null,surname:"Martínez-Córdoba",slug:"luis-rafael-martinez-cordoba",fullName:"Luis Rafael Martínez-Córdoba"}]},{id:"62247",doi:"10.5772/intechopen.77315",title:"Application of Biosorption for Removal of Heavy Metals from Wastewater",slug:"application-of-biosorption-for-removal-of-heavy-metals-from-wastewater",totalDownloads:7571,totalCrossrefCites:72,totalDimensionsCites:139,abstract:"Fresh water accounts for 3% of water resources on the Earth. Human and industrial activities produce and discharge wastes containing heavy metals into the water resources making them unavailable and threatening human health and the ecosystem. Conventional methods for the removal of metal ions such as chemical precipitation and membrane filtration are extremely expensive when treating large amounts of water, inefficient at low concentrations of metal (incomplete metal removal) and generate large quantities of sludge and other toxic products that require careful disposal. Biosorption and bioaccumulation are ecofriendly alternatives. These alternative methods have advantages over conventional methods. Abundant natural materials like microbial biomass, agro-wastes, and industrial byproducts have been suggested as potential biosorbents for heavy metal removal due to the presence of metal-binding functional groups. Biosorption is influenced by various process parameters such as pH, temperature, initial concentration of the metal ions, biosorbent dose, and speed of agitation. Also, the biomass can be modified by physical and chemical treatment before use. The process can be made economical by regenerating and reusing the biosorbent after removing the heavy metals. Various bioreactors can be used in biosorption for the removal of metal ions from large volumes of water or effluents. The recent developments and the future scope for biosorption as a wastewater treatment option are discussed.",book:{id:"6137",slug:"biosorption",title:"Biosorption",fullTitle:"Biosorption"},signatures:"Sri Lakshmi Ramya Krishna Kanamarlapudi, Vinay Kumar\nChintalpudi and Sudhamani Muddada",authors:[{id:"238433",title:"Associate Prof.",name:"Sudhamani",middleName:null,surname:"Muddada",slug:"sudhamani-muddada",fullName:"Sudhamani Muddada"},{id:"244937",title:"Mrs.",name:"S L Ramyakrishna",middleName:null,surname:"Kanamarlapudi",slug:"s-l-ramyakrishna-kanamarlapudi",fullName:"S L Ramyakrishna Kanamarlapudi"},{id:"244938",title:"Mr.",name:"Vinay Kumar",middleName:null,surname:"Chintalpudi",slug:"vinay-kumar-chintalpudi",fullName:"Vinay Kumar Chintalpudi"}]}],mostDownloadedChaptersLast30Days:[{id:"69568",title:"Water Quality Parameters",slug:"water-quality-parameters",totalDownloads:9909,totalCrossrefCites:12,totalDimensionsCites:32,abstract:"Since the industrial revolution in the late eighteenth century, the world has discovered new sources of pollution nearly every day. So, air and water can potentially become polluted everywhere. Little is known about changes in pollution rates. The increase in water-related diseases provides a real assessment of the degree of pollution in the environment. This chapter summarizes water quality parameters from an ecological perspective not only for humans but also for other living things. According to its quality, water can be classified into four types. Those four water quality types are discussed through an extensive review of their important common attributes including physical, chemical, and biological parameters. These water quality parameters are reviewed in terms of definition, sources, impacts, effects, and measuring methods.",book:{id:"7718",slug:"water-quality-science-assessments-and-policy",title:"Water Quality",fullTitle:"Water Quality - Science, Assessments and Policy"},signatures:"Nayla Hassan Omer",authors:null},{id:"58138",title:"Water Pollution: Effects, Prevention, and Climatic Impact",slug:"water-pollution-effects-prevention-and-climatic-impact",totalDownloads:21487,totalCrossrefCites:18,totalDimensionsCites:36,abstract:"The stress on our water environment as a result of increased industrialization, which aids urbanization, is becoming very high thus reducing the availability of clean water. Polluted water is of great concern to the aquatic organism, plants, humans, and climate and indeed alters the ecosystem. The preservation of our water environment, which is embedded in sustainable development, must be well driven by all sectors. While effective wastewater treatment has the tendency of salvaging the water environment, integration of environmental policies into the actor firms core objectives coupled with continuous periodical enlightenment on the present and future consequences of environmental/water pollution will greatly assist in conserving the water environment.",book:{id:"6157",slug:"water-challenges-of-an-urbanizing-world",title:"Water Challenges of an Urbanizing World",fullTitle:"Water Challenges of an Urbanizing World"},signatures:"Inyinbor Adejumoke A., Adebesin Babatunde O., Oluyori Abimbola\nP., Adelani-Akande Tabitha A., Dada Adewumi O. and Oreofe Toyin\nA.",authors:[{id:"101570",title:"MSc.",name:"Babatunde Olufemi",middleName:null,surname:"Adebesin",slug:"babatunde-olufemi-adebesin",fullName:"Babatunde Olufemi Adebesin"},{id:"187738",title:"Dr.",name:"Adejumoke",middleName:"Abosede",surname:"Inyinbor",slug:"adejumoke-inyinbor",fullName:"Adejumoke Inyinbor"},{id:"188818",title:"Dr.",name:"Abimbola",middleName:null,surname:"Oluyori",slug:"abimbola-oluyori",fullName:"Abimbola Oluyori"},{id:"188819",title:"Mrs.",name:"Tabitha",middleName:null,surname:"Adelani-Akande",slug:"tabitha-adelani-akande",fullName:"Tabitha Adelani-Akande"},{id:"208501",title:"Dr.",name:"Adewumi",middleName:null,surname:"Dada",slug:"adewumi-dada",fullName:"Adewumi Dada"},{id:"208502",title:"Ms.",name:"Toyin",middleName:null,surname:"Oreofe",slug:"toyin-oreofe",fullName:"Toyin Oreofe"}]},{id:"45422",title:"Urban Waterfront Regenerations",slug:"urban-waterfront-regenerations",totalDownloads:14033,totalCrossrefCites:4,totalDimensionsCites:12,abstract:null,book:{id:"3560",slug:"advances-in-landscape-architecture",title:"Advances in Landscape Architecture",fullTitle:"Advances in Landscape Architecture"},signatures:"Umut Pekin Timur",authors:[{id:"165480",title:"Dr.",name:"Umut",middleName:null,surname:"Pekin Timur",slug:"umut-pekin-timur",fullName:"Umut Pekin Timur"}]},{id:"24941",title:"Tsunami in Makran Region and Its Effect on the Persian Gulf",slug:"tsunami-in-makran-region-and-its-effect-on-the-persian-gulf",totalDownloads:7384,totalCrossrefCites:4,totalDimensionsCites:7,abstract:null,book:{id:"406",slug:"tsunami-a-growing-disaster",title:"Tsunami",fullTitle:"Tsunami - A Growing Disaster"},signatures:"Mohammad Mokhtari",authors:[{id:"52451",title:"Dr.",name:"Mohammad",middleName:null,surname:"Mokhtari",slug:"mohammad-mokhtari",fullName:"Mohammad Mokhtari"}]},{id:"66307",title:"Bio-hydrogen and Methane Production from Lignocellulosic Materials",slug:"bio-hydrogen-and-methane-production-from-lignocellulosic-materials",totalDownloads:2934,totalCrossrefCites:5,totalDimensionsCites:7,abstract:"This chapter covers the information on bio-hydrogen and methane production from lignocellulosic materials. Pretreatment methods of lignocellulosic materials and the factors affecting bio-hydrogen production, both dark- and photo-fermentation, and methane production are addressed. Last but not least, the processes for bio-hydrogen and methane production from lignocellulosic materials are discussed.",book:{id:"7608",slug:"biomass-for-bioenergy-recent-trends-and-future-challenges",title:"Biomass for Bioenergy",fullTitle:"Biomass for Bioenergy - Recent Trends and Future Challenges"},signatures:"Apilak Salakkam, Pensri Plangklang, Sureewan Sittijunda, Mallika Boonmee Kongkeitkajorn, Siriporn Lunprom and Alissara Reungsang",authors:null}],onlineFirstChaptersFilter:{topicId:"12",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82362",title:"Studies on the Short-Term Effects of the Cease of Pesticides Use on Vineyard Microbiome",slug:"studies-on-the-short-term-effects-of-the-cease-of-pesticides-use-on-vineyard-microbiome",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.105706",abstract:"In this chapter, an overview of the impact of phytosanitary treatments on the vineyard microbiome is provided, together with the results of the research we conducted. The studied plant material consisted of grapevine from the cultivars Sauvignon blanc and Cabernet Sauvignon, cultivated within the plantation of the Research Station for Viticulture and Enology from Murfatlar, Romania. For each cultivar, a treated plot and an untreated plot were established. For each of those, the phyllosphere microbiota was quantified using the epifluorescence microscopy method, followed by automated image analysis using CellC software. At the same time, the soil fungal diversity was evaluated in three stages during the year 2021, using microscopic morphological criteria. The results give useful information regarding the phytosanitary state of the studied plant, as well as the short-term effects produced by the ceasing of pesticide application on the grapevine microbiota.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Simona Ghiță, Mihaela Hnatiuc, Aurora Ranca, Victoria Artem and Mădălina-Andreea Ciocan"},{id:"82316",title:"Stakeholder Integration and Participatory Processes as Part of an Ecosystem-Based and Integrated Natural Hazard Risk Management",slug:"stakeholder-integration-and-participatory-processes-as-part-of-an-ecosystem-based-and-integrated-nat",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.99516",abstract:"Participatory processes have been receiving growing attention in recent decades, especially in the environmental field. There is no unique way for designing and managing a participatory process: different types of integrating stakeholders and communities have been applied, encompassing different scopes. Participatory processes become necessary when addressing complex environmental challenges, which require flexible and transparent approaches embracing diverse knowledge and values. Integrated risk management, including Ecosystem-based solutions for Disaster Risk Reduction (Eco-DRR), is one example of such a challenge, being a joint responsibility of public institutions at different levels of public management and of the private sector. The project GreenRisk4ALPs is an example of how including local experts can be translated into practice. A stakeholder network analysis was carried out, which provided the basis to select the stakeholders involved in the subsequent participatory processes and to identify conflicts and interests related to Eco-DRR. Building upon this analysis, Rapid Risk management Appraisal workshops were carried out in different study areas to jointly analyze the strengths and weaknesses related to current risk management practices. Overall, the involvement of stakeholders from the beginning allowed to respond to their needs contributing to the improvement of risk management strategies in the Alpine Region.",book:{id:"10812",title:"Protective forests as Ecosystem-based solution for Disaster Risk Reduction (ECO-DRR)",coverURL:"//cdnintech.com/web/frontend/www/assets/cover.jpg"},signatures:"Silvia Cocuccioni, Matthias Plörer and Michael Kirchner"},{id:"82297",title:"The Climate Change-Agriculture Nexus in Drylands of Ethiopia",slug:"the-climate-change-agriculture-nexus-in-drylands-of-ethiopia",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103905",abstract:"The objective of this chapter is to review the impacts of climate change on dryland agriculture and its possible solutions. Climate change poses significant challenges on dryland agriculture in Ethiopia. In turn, agriculture (malpractice) has contributed to climate change by emitting GHGs such as CO2, CH4 and N2O. Globally, agriculture’s contribution takes 14% of CO2, 47% of CH4 and 84% of N2O. Agriculture contributes to 80% of total Ethiopia’s GHGs emission: CH4, N2O and CO2, respectively, contributed to 72, 15 and 14% to aggregated emission. To soothe the impacts of climate change, countries should act now differently together to stabilize the fractions of GHGs in the atmosphere at a level that would also stabilize the climate system. Adopting climate-compatible agricultural development strategies can enable to reduce agricultural GHGs emissions or sequestration enhanced while maintaining and even increasing food supply. It is understood that combating desertification, land degradation and mitigating the effects of drought are the basis for accelerated sustainable development, poverty reduction and ensuring food security in Ethiopia. Climate-smart dryland agriculture can maintain livestock and crop productivity, reduces GHGs emission, lessens the impact of climate change and reduces the trade-offs among agricultural development to fulfill food security, climate change and ecosystem degradation.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Zenebe Mekonnen"},{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104982",abstract:"This study assessed the abundance and diversity of trees, estimated the growth characteristics and determined the aboveground biomass of the trees within three selected green areas, namely Riparian Corridor was abbreviated as Riparian corridor (RC), Industrial sites (IS), and Residential sites (RS) in Osogbo, Southwestern Nigeria. Species Diversity Index, Relative Dominance, and Importance Value Index of trees were also estimated. Trees\\' diversity and ranking were determined using the R statistical package. A total number of 124 tree stems were enumerated and (RC), (IS), and (RS) had 49, 38, and 37 tree stems belonging to 27, 18 and 20 species respectively. Albizia zygia (Mimosaceae) was the most abundant species in both RC and IS, while Milicia excelsa (Moraceae) was the most abundant in the RS. Growth variables were recorded as 1.18 m2, 5.01 m2, and 11.06 m2 (basal area), and 13.49 m3, 64.03 m3 and 122.39 m3 (volume) for RC, IS, and RS, respectively. The highest mean aboveground biomass was recorded in the RS (28325.20±7639.57 Kg C ha−1). There was no significant difference (P≥ 0.01) between the aboveground biomass of RC and IS but a significant difference (P≥ 0.01) existed between the aboveground biomass of RC and RS. 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This chapter draws on the findings of a study that explored how climate change affects the livelihoods and ultimately the well-being of farming and fishing households in a remote rural area in Kenya and discusses the coping strategies adopted by these communities. Understanding how climate change impacts people’s livelihoods is important as a precursor to assist communities to adapt to and cope with the adverse effects of climate change. The results pointed to relatively wide utilization of traditional knowledge in coping strategies. Conversely, robust modern technologies for forecasting weather patterns remain under-utilized among the target population. The chapter concludes with recommendations to capitalize on and strengthen the existing coping strategies of the affected communities.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"André J. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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