IR isoform mRNA expression in humans and animal models expressed as percentage of IR-A and IR-B.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5912",leadTitle:null,fullTitle:"Empathy - An Evidence-based Interdisciplinary Perspective",title:"Empathy",subtitle:"An Evidence-based Interdisciplinary Perspective",reviewType:"peer-reviewed",abstract:"Empathy, a basic ability for understanding persons holistically, building supportive relationships, and listening attentively, includes being with suffering persons, healing, and inducing catharsis in them. Therefore, it is necessary within occupations supporting humans: education, clinical psychology, nursing, early childhood care, welfare, and medicine. Conversely, there are individual differences in empathy, and promoting its development is difficult. In this book, we use interdisciplinary approaches to empathy; for example, we discuss a new intervention, physical and cross-cultural understanding of empathy, development of empathy, and applications in general and professional education. The significance of this book is its evidence-based interdisciplinary perspective in understanding empathy.",isbn:"978-953-51-3454-1",printIsbn:"978-953-51-3453-4",pdfIsbn:"978-953-51-4701-5",doi:"10.5772/66004",price:119,priceEur:129,priceUsd:155,slug:"empathy-an-evidence-based-interdisciplinary-perspective",numberOfPages:180,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"f009b7045eb6221228449100ba23cca0",bookSignature:"Makiko Kondo",publishedDate:"August 23rd 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5912.jpg",numberOfDownloads:11934,numberOfWosCitations:10,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:22,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:46,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 25th 2016",dateEndSecondStepPublish:"November 15th 2016",dateEndThirdStepPublish:"February 11th 2017",dateEndFourthStepPublish:"May 12th 2017",dateEndFifthStepPublish:"July 11th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"188019",title:"Dr.",name:"Makiko",middleName:null,surname:"Kondo",slug:"makiko-kondo",fullName:"Makiko Kondo",profilePictureURL:"https://mts.intechopen.com/storage/users/188019/images/system/188019.jpeg",biography:"Dr. Makiko Kondo obtained Bachelor of Education and Registered Nurse degrees from Tokushima University in 1989, a Master of Science in Nursing from Chiba University in 2000, and a Doctor of Philosophy in Nursing from Osaka Prefecture University in 2007. Currently, she is Professor at Kagawa Prefectural University of Health Sciences, Japan. She teaches doctoral, master’s, and undergraduate courses. Her field of expertise is qualitative studies. Her research themes involve care for dying parents and their young children, nurses’ grief care, conceptualization of clinical nursing competency, medical ethics, and life review of a Hansen’s disease survivor who had experienced an extreme state.",institutionString:"Okayama University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Okayama University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1246",title:"Emotional Empathy",slug:"emotional-empathy"}],chapters:[{id:"55718",title:"Space Travels and Empathy: A New Area of Educational Intervention",doi:"10.5772/intechopen.69288",slug:"space-travels-and-empathy-a-new-area-of-educational-intervention",totalDownloads:1337,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Empathy is a relevant factor which the astronauts must own to face with long missions. In fact, the absence of this can be a cause of a fail mission. Due to the fact space projects involve a great invest, the way of developing empathy on crew and the teaching of strategies is a priority. For all this, the main goal of this paper was to analyze the current situation of the research on empathy concerning space travels. The specific objectives were (a) to find out how this issue and other psychological variables were related to astronauts and space travels and (b) to propose aspects for the design of an educational program to encourage people to solve social problems and develop social skills. For that, a review was made by using diferent databases and diferent resources by studying several variables related to empathy and long-duration space missions. Findings show that the psychological variables will be specially relevant in future missions and space colonization, as for instance, on Mars or the Moon. Conclusions can be useful to design educational programs to train crew members and control mission personnel on empathy and problem solving.",signatures:"Juan Pedro Martínez Ramón",downloadPdfUrl:"/chapter/pdf-download/55718",previewPdfUrl:"/chapter/pdf-preview/55718",authors:[{id:"200169",title:"Dr.",name:"Juan Pedro",surname:"Martínez Ramón",slug:"juan-pedro-martinez-ramon",fullName:"Juan Pedro Martínez Ramón"}],corrections:null},{id:"56509",title:"Neuroimaging Research on Empathy and Shared Neural Networks",doi:"10.5772/intechopen.70134",slug:"neuroimaging-research-on-empathy-and-shared-neural-networks",totalDownloads:1744,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Understanding other people’s feelings and perspectives is an important part of effective social communication and interaction. Empathy is the phenomenon that enables us to infer the feelings of others and understand their mental states. It aids in social learning and bonding and is thought to be impaired in individuals with social deficits like schizophrenia and autism spectrum disorder (ASD). Advances in neuroimaging technology have allowed social neuroscientists to study brain activity during this complex social process. A growing body of empathy literature demonstrates that multiple brain regions are involved in empathy. Current theories propose that empathy is enabled through the activation of various dynamic neural networks, each made up of several different regions. These networks respond differently depending on specific contexts and available information. This chapter reviews the networks involved in empathy and highlights the current theories and limitations of empathy research.",signatures:"Emily Kilroy and Lisa Aziz-Zadeh",downloadPdfUrl:"/chapter/pdf-download/56509",previewPdfUrl:"/chapter/pdf-preview/56509",authors:[{id:"201496",title:"Dr.",name:"Lisa",surname:"Aziz-Zadeh",slug:"lisa-aziz-zadeh",fullName:"Lisa Aziz-Zadeh"},{id:"201497",title:"M.Sc.",name:"Emily",surname:"Kilroy",slug:"emily-kilroy",fullName:"Emily Kilroy"}],corrections:null},{id:"55598",title:"A Less Attractive Feature of Empathy: Intergroup Empathy Bias",doi:"10.5772/intechopen.69287",slug:"a-less-attractive-feature-of-empathy-intergroup-empathy-bias",totalDownloads:1832,totalCrossrefCites:7,totalDimensionsCites:9,hasAltmetrics:1,abstract:"Empathy with others’ successes and misfortunes is a critical component of group living that promotes social cohesion. Unfortunately, empathy is a malleable phenomenon in that its elicitation is not automatic, but modulated by multiple interlocking factors. This chapter explores the specific phenomenon of intergroup empathy bias—the difference in empathy for members of social ingroups versus outgroups—which poses profound challenges for our modern human world characterized by a multitude of groups, ethnicities, and cultures. The chapter frames the discussion by contextualizing empathy as consisting of three interacting component processes, namely experience sharing, perspective taking, and empathic concern. It then goes on to examine research describing the effects of intergroup bias on each of these component processes. Next, it explores the factors, both at the level of the group and at the level of the individual, which may contribute to empathic breakdown in intergroup contexts. Finally, it considers strategies that may have potential in mitigating intergroup empathy bias. Here, we draw on our own experiences in the South African context, which is characterized by pervasive racial inequality and legacies of apartheid violence, to suggest that intergroup empathy is best stimulated in a context of reciprocal mutual engagement with the other.",signatures:"Melike M. Fourie, Sivenesi Subramoney and Pumla Gobodo‐\nMadikizela",downloadPdfUrl:"/chapter/pdf-download/55598",previewPdfUrl:"/chapter/pdf-preview/55598",authors:[{id:"201227",title:"Dr.",name:"Melike",surname:"Fourie",slug:"melike-fourie",fullName:"Melike Fourie"},{id:"201250",title:"MSc.",name:"Sivenesi",surname:"Subramoney",slug:"sivenesi-subramoney",fullName:"Sivenesi Subramoney"},{id:"201512",title:"Prof.",name:"Pumla",surname:"Gobodo-Madikizela",slug:"pumla-gobodo-madikizela",fullName:"Pumla Gobodo-Madikizela"}],corrections:null},{id:"56121",title:"Introducing Educational Intervention about Empathy and Intercultural Bias",doi:"10.5772/intechopen.69626",slug:"introducing-educational-intervention-about-empathy-and-intercultural-bias",totalDownloads:1255,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Literature about empathy and intergroup bias considers a lot of research from many different approaches. However, there is certain degree of consensus that has been achieved in relation to the determination of the behavioral correlate of the empathy. Recently, its importance connected to the pro-social attitude of people has been emphasized, as well as its role played in social conflicts. So, the empathic response has to do with the ability to comprehend the other person and to try to think as the other person thinks, by means of observing him/her, using verbal and no verbal information or other type of evidences approachable from the memory, what is called, perspective taking. Empathy, understood in that way, would play a central role in the pro-social attitude of people. After introducing the most important pillars of this chapter, which are empathy and pro-social behavior, intercultural empathy, intergroup contact and, finally, “empathy, bias and education,” different kinds of interventions about bias and empathy in education are presented. We will find that it is not only necessary but possible to put through strategies adapted to different ages and circumstances with a common goal: to improve empathy and control bias through education.",signatures:"Hugo González González",downloadPdfUrl:"/chapter/pdf-download/56121",previewPdfUrl:"/chapter/pdf-preview/56121",authors:[{id:"200421",title:"Dr.",name:"Hugo",surname:"Gonzalez Gonzalez",slug:"hugo-gonzalez-gonzalez",fullName:"Hugo Gonzalez Gonzalez"}],corrections:null},{id:"55622",title:"The Influence of Suffering, Social Class, and Social Power on Prosociality: An Empirical Review",doi:"10.5772/intechopen.69285",slug:"the-influence-of-suffering-social-class-and-social-power-on-prosociality-an-empirical-review",totalDownloads:1256,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An emerging body of research has shed light on the effects of social‐environmental factors, such as exposure to suffering, social class, and social power on prosocial orientation (i.e., empathy and compassion). This chapter aims to provide an overview of these areas of research that examined how the aforementioned social‐environmental factors may accentuate or attenuate one’s tendency to be prosocial. In addition, this chapter explores the theoretical implications across these areas and its potential for future research.",signatures:"Daniel Lim",downloadPdfUrl:"/chapter/pdf-download/55622",previewPdfUrl:"/chapter/pdf-preview/55622",authors:[{id:"199564",title:"Ph.D. Student",name:"Daniel",surname:"Lim",slug:"daniel-lim",fullName:"Daniel Lim"}],corrections:null},{id:"56048",title:"The Building of Empathy: Conceptual “Pillars” and Conversational Practices in Psychotherapy",doi:"10.5772/intechopen.69628",slug:"the-building-of-empathy-conceptual-pillars-and-conversational-practices-in-psychotherapy",totalDownloads:1426,totalCrossrefCites:3,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Empathy can be considered a special type of cooperation between therapist and patient. This exploratory study compares psychoanalytical, depth-psychological and behavioural therapy, in each case using transcriptions of audio recordings of initial, mid-term and late sessions. For each school of therapy, five treatments are included, creating a database of 45 sessions. We describe the project and the method of conversation analysis using examples of these transcripts and hypothesise that while all three schools of therapy are faced with common fundamental problems concerning the realisation of empathy, one can observe empathy profiles specific to each school. Here, we introduce theoretical groundwork and the terminology of conversation analysis. The topic may be of particular interest to clinicians, since everyday problems are examined through the prism of microanalysis.",signatures:"Michael B. Buchholz, Jörg Bergmann, Marie-Luise Alder, Michael M.\nDittmann, Florian Dreyer and Horst Kächele",downloadPdfUrl:"/chapter/pdf-download/56048",previewPdfUrl:"/chapter/pdf-preview/56048",authors:[{id:"201361",title:"Dr.",name:"Michael B.",surname:"Buchholz",slug:"michael-b.-buchholz",fullName:"Michael B. Buchholz"},{id:"219722",title:"M.A.",name:"Michael M.",surname:"Dittmann",slug:"michael-m.-dittmann",fullName:"Michael M. Dittmann"}],corrections:null},{id:"55144",title:"The Role of Empathy in Dealing with the Complexity and Uncertainty within the Educational Field: Meaningful Learning at the “Museum Adventure” Course",doi:"10.5772/intechopen.68670",slug:"the-role-of-empathy-in-dealing-with-the-complexity-and-uncertainty-within-the-educational-field-mean",totalDownloads:1218,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Empathic practices highlight teachers’ emotional, social, and cognitive competence and play an important role in taking beneficial action in the classroom. The current manuscript explains the need and the significance of empathic proficiencies in meeting the present needs of promoting meaningful learning processes and dealing with the uncertainty and complexity of the educational field. The approaches, patterns of activity, and methods of qualitative researchers are proposed as a way to enrich the practices of educators in the context‐based reality in which they live and work. The implementation of these ideas is presented through the description of a “Museum Adventure” course in an undergraduate education program for pre‐service preschool teachers. The course aims to promote students’ social understanding, sensitivity, and involvement.",signatures:"Yehudith Weinberger",downloadPdfUrl:"/chapter/pdf-download/55144",previewPdfUrl:"/chapter/pdf-preview/55144",authors:[{id:"201297",title:"Dr.",name:"Yehudith",surname:"Weinberger",slug:"yehudith-weinberger",fullName:"Yehudith Weinberger"}],corrections:null},{id:"56023",title:"Empathy Levels in Medical Students: Do They Really Change Over Time?",doi:"10.5772/intechopen.69625",slug:"empathy-levels-in-medical-students-do-they-really-change-over-time-",totalDownloads:1866,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"There is conceptual ambiguity in defining empathy, which is further amplified when trying to define clinical empathy. The construct of empathy has been an ongoing debate: sometimes being interpreted as a cognitive attribute, other times as an emotional state of mind. Our preferred definition is moral, emotive, cognitive and behavioural dimensions working in harmony to benefit the patient. Understanding the feelings, attitudes and experiences of a patient is the first step towards a potent and effective interview and, thereby, therapeutic agreement. Thus, clinical empathy may be the most powerful tool for a successful collaboration between the patient and the doctor. This chapter discusses the history of clinical empathy starting with Sir William Osler’s definition of ‘neutral empathy’ where he argues that physicians need to neutralise their emotions so that they can ‘see into’ and, thereby, be able to ‘study’ the patient’s ‘inner life’, to Halpern’s insightful observations about the power of empathy, which ‘lies in its ability to help us cross the divide between clinicians and patients created by their very different circumstances’. This is followed by a summary of the literature deliberating the increasing concern among medical educators and medical professionals regarding the decline in medical students’ empathy during medical school, which brings us to our research question: are there significant changes in empathy levels over time in undergraduate medical education? This body of work reports on a cross-sectional study of all medical students enrolled at an Australian medical school, known for its cultural, social and religious diversity, in 2011. The research instrument used consisted of a survey encompassing questions on demographics in addition to the Jefferson Scale of Physician Empathy, Student version (JSPE-S). Empathy levels were compared while controlling for effects of age, gender, marital status, religious belief, ethnicity/cultural background, year of medical training, previous education and level of completion of programmes promoting altruism in an attempt to identify their effect on the levels of empathy. A total of 404 students participated in the study. The scores of the JSPE-S ranged from 34 to 135 with a mean score of 109.07 ± 14.937. This is considered moderate to high when compared to reported scores in previous studies on medical students. Female medical students had significantly higher empathy scores compared to their male counterparts in total and in individual years. Contrary to the literature, there were no significant differences in empathy scores in relation to the stage of medical training. Findings suggest that there is a gender difference in the levels of empathy, favouring female medical students, and that empathy levels may be preserved in medical school despite prior evidence that a decline is pervasive.",signatures:"Iman Hegazi, Annemarie Hennessy and Ian Wilson",downloadPdfUrl:"/chapter/pdf-download/56023",previewPdfUrl:"/chapter/pdf-preview/56023",authors:[{id:"199901",title:"Dr.",name:"Iman",surname:"Hegazi",slug:"iman-hegazi",fullName:"Iman Hegazi"},{id:"200210",title:"Prof.",name:"Ian",surname:"Wilson",slug:"ian-wilson",fullName:"Ian Wilson"},{id:"200211",title:"Prof.",name:"Annemarie",surname:"Hennessy",slug:"annemarie-hennessy",fullName:"Annemarie Hennessy"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7507",title:"Empathy Study",subtitle:null,isOpenForSubmission:!1,hash:"e8318dbbb1e524384596da018870651f",slug:"empathy-study",bookSignature:"Makiko Kondo and Bala Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/7507.jpg",editedByType:"Edited by",editors:[{id:"188019",title:"Dr.",name:"Makiko",surname:"Kondo",slug:"makiko-kondo",fullName:"Makiko Kondo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"80612",slug:"corrigendum-to-risk-assessment-and-health-safety-and-environmental-management-of-carbon-nanomaterial",title:"Corrigendum to: Risk Assessment and Health, Safety, and Environmental Management of Carbon Nanomaterials",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/80612.pdf",downloadPdfUrl:"/chapter/pdf-download/80612",previewPdfUrl:"/chapter/pdf-preview/80612",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/80612",risUrl:"/chapter/ris/80612",chapter:{id:"66689",slug:"risk-assessment-and-health-safety-and-environmental-management-of-carbon-nanomaterials",signatures:"Guilherme Lenz e Silva, Camila Viana, Danieli Domingues and Fernanda Vieira",dateSubmitted:null,dateReviewed:"February 26th 2019",datePrePublished:"April 11th 2019",datePublished:"February 19th 2020",book:{id:"8137",title:"Nanomaterials",subtitle:"Toxicity, Human Health and Environment",fullTitle:"Nanomaterials - Toxicity, Human Health and Environment",slug:"nanomaterials-toxicity-human-health-and-environment",publishedDate:"February 19th 2020",bookSignature:"Simona Clichici, Adriana Filip and Gustavo M. do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/8137.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"64160",title:"Prof.",name:"Simona",middleName:null,surname:"Clichici",slug:"simona-clichici",fullName:"Simona Clichici"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"251730",title:"Dr.",name:"Guilherme",middleName:"Fredeico Bernardo",surname:"Lenz E Silva",fullName:"Guilherme Lenz E Silva",slug:"guilherme-lenz-e-silva",email:"guilhermelenz@usp.br",position:null,institution:null},{id:"286148",title:"Dr.",name:"Camila",middleName:null,surname:"Viana",fullName:"Camila Viana",slug:"camila-viana",email:"camilaoviana@gmail.com",position:null,institution:null},{id:"286149",title:"Dr.",name:"Fernanda",middleName:null,surname:"Vieira",fullName:"Fernanda Vieira",slug:"fernanda-vieira",email:"fevieira2001@gmail.com",position:null,institution:null},{id:"286151",title:"M.Sc.",name:"Danieli",middleName:"Silva",surname:"Domingues",fullName:"Danieli Domingues",slug:"danieli-domingues",email:"danielisilva@ymail.com",position:null,institution:null}]}},chapter:{id:"66689",slug:"risk-assessment-and-health-safety-and-environmental-management-of-carbon-nanomaterials",signatures:"Guilherme Lenz e Silva, Camila Viana, Danieli Domingues and Fernanda Vieira",dateSubmitted:null,dateReviewed:"February 26th 2019",datePrePublished:"April 11th 2019",datePublished:"February 19th 2020",book:{id:"8137",title:"Nanomaterials",subtitle:"Toxicity, Human Health and Environment",fullTitle:"Nanomaterials - Toxicity, Human Health and Environment",slug:"nanomaterials-toxicity-human-health-and-environment",publishedDate:"February 19th 2020",bookSignature:"Simona Clichici, Adriana Filip and Gustavo M. do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/8137.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"64160",title:"Prof.",name:"Simona",middleName:null,surname:"Clichici",slug:"simona-clichici",fullName:"Simona Clichici"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"251730",title:"Dr.",name:"Guilherme",middleName:"Fredeico Bernardo",surname:"Lenz E Silva",fullName:"Guilherme Lenz E Silva",slug:"guilherme-lenz-e-silva",email:"guilhermelenz@usp.br",position:null,institution:null},{id:"286148",title:"Dr.",name:"Camila",middleName:null,surname:"Viana",fullName:"Camila Viana",slug:"camila-viana",email:"camilaoviana@gmail.com",position:null,institution:null},{id:"286149",title:"Dr.",name:"Fernanda",middleName:null,surname:"Vieira",fullName:"Fernanda Vieira",slug:"fernanda-vieira",email:"fevieira2001@gmail.com",position:null,institution:null},{id:"286151",title:"M.Sc.",name:"Danieli",middleName:"Silva",surname:"Domingues",fullName:"Danieli Domingues",slug:"danieli-domingues",email:"danielisilva@ymail.com",position:null,institution:null}]},book:{id:"8137",title:"Nanomaterials",subtitle:"Toxicity, Human Health and Environment",fullTitle:"Nanomaterials - Toxicity, Human Health and Environment",slug:"nanomaterials-toxicity-human-health-and-environment",publishedDate:"February 19th 2020",bookSignature:"Simona Clichici, Adriana Filip and Gustavo M. do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/8137.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"64160",title:"Prof.",name:"Simona",middleName:null,surname:"Clichici",slug:"simona-clichici",fullName:"Simona Clichici"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11783",leadTitle:null,title:"Motivation and Success",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThis book will aim to be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, psychologists, social workers, mentors, motivational speakers, life coaches, students, and other scientists. The contents of the book are intended to be written by multiple authors and experts from different related fields of psychology, philosophy, education, public health, human resource, and other human social sciences.
\r\n\r\n\tCombining Motivation and Success as a book title demonstrates that these are complementary goods. When two goods are complements, they experience join demand. Meaning that the demand for one good is linked to the demand for another good. Indeed, our esteemed authors will aim to put together their scholarly work to showcase the importance of motivation leading to success and vice versa. Defined as a drive or a need, motivation is a driving force inside an individual to pursue a designated goal. While success is a state of meeting a targeted goal. This simply implies that motivated individuals are most successful and this is the core theme of the book.
",isbn:"978-1-83768-021-4",printIsbn:"978-1-83768-020-7",pdfIsbn:"978-1-83768-022-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"f660b7cd35b9af94bdfc3564df138161",bookSignature:"Dr. Simon George Taukeni",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11783.jpg",keywords:"Inner Motivation, Self-Regulation, Self-Control, Exercise, Sport, External Motivation, Secrets Behind Success, Being Physically Active, Feeling Successful, Theories Behind Success, Adversity, Motivational Speech",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 10th 2022",dateEndSecondStepPublish:"June 7th 2022",dateEndThirdStepPublish:"August 6th 2022",dateEndFourthStepPublish:"October 25th 2022",dateEndFifthStepPublish:"December 24th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"11 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher within the biopsychosocial model and health psychology. He also works as an editor, internal and external examiner, and principal project investigator.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"202046",title:"Dr.",name:"Simon George",middleName:null,surname:"Taukeni",slug:"simon-george-taukeni",fullName:"Simon George Taukeni",profilePictureURL:"https://mts.intechopen.com/storage/users/202046/images/system/202046.jpg",biography:"Simon George Taukeni is an author, editor, and academic. He has been working at the University of Namibia since 2011. He is also a part-time tutor at Namibia University of Science and Technology (NUST). He is a former post-doctoral research fellow at the University of Fort Hare, South Africa.\n\nDr. Taukeni has a Ph.D., MPH, MEd, and BEd, as well as a specialized postgraduate diploma in Behavioral and Emotional Disorders. \n\nHe has collaborated with many local and international researchers and scholars in his capacity as an editor, internal and external examiner, and principal project investigator.",institutionString:"University of Namibia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"University of Namibia",institutionURL:null,country:{name:"Namibia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"21",title:"Psychology",slug:"psychology"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. A unique name with a unique work ethic right at your service."}},relatedBooks:[{type:"book",id:"6494",title:"Behavior Analysis",subtitle:null,isOpenForSubmission:!1,hash:"72a81a7163705b2765f9eb0b21dec70e",slug:"behavior-analysis",bookSignature:"Huei-Tse Hou and Carolyn S. Ryan",coverURL:"https://cdn.intechopen.com/books/images_new/6494.jpg",editedByType:"Edited by",editors:[{id:"96493",title:"Prof.",name:"Huei Tse",surname:"Hou",slug:"huei-tse-hou",fullName:"Huei Tse Hou"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9052",title:"Psychoanalysis",subtitle:"A New Overview",isOpenForSubmission:!1,hash:"69cc7a085f5417038f532cf11edee22f",slug:"psychoanalysis-a-new-overview",bookSignature:"Floriana Irtelli, Barbara Marchesi and Federico Durbano",coverURL:"https://cdn.intechopen.com/books/images_new/9052.jpg",editedByType:"Edited by",editors:[{id:"174641",title:"Dr.",name:"Floriana",surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10981",title:"Sport Psychology in Sports, Exercise and Physical Activity",subtitle:null,isOpenForSubmission:!1,hash:"5214c44bdc42978449de0751ca364684",slug:"sport-psychology-in-sports-exercise-and-physical-activity",bookSignature:"Hilde G. Nielsen",coverURL:"https://cdn.intechopen.com/books/images_new/10981.jpg",editedByType:"Edited by",editors:[{id:"158692",title:"Ph.D.",name:"Hilde",surname:"Nielsen",slug:"hilde-nielsen",fullName:"Hilde Nielsen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10211",title:"The Science of Emotional Intelligence",subtitle:null,isOpenForSubmission:!1,hash:"447fc7884303a10093bc189f4c82dd47",slug:"the-science-of-emotional-intelligence",bookSignature:"Simon George Taukeni",coverURL:"https://cdn.intechopen.com/books/images_new/10211.jpg",editedByType:"Edited by",editors:[{id:"202046",title:"Dr.",name:"Simon George",surname:"Taukeni",slug:"simon-george-taukeni",fullName:"Simon George Taukeni"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7811",title:"Beauty",subtitle:"Cosmetic Science, Cultural Issues and Creative Developments",isOpenForSubmission:!1,hash:"5f6fd59694706550db8dd1082a8e457b",slug:"beauty-cosmetic-science-cultural-issues-and-creative-developments",bookSignature:"Martha Peaslee Levine and Júlia Scherer Santos",coverURL:"https://cdn.intechopen.com/books/images_new/7811.jpg",editedByType:"Edited by",editors:[{id:"186919",title:"Dr.",name:"Martha",surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"46327",title:"Ocean Carbon Sequestration by Direct Injection",doi:"10.5772/57386",slug:"ocean-carbon-sequestration-by-direct-injection",body:'The ocean is the largest sink of atmospheric CO2 (about 7 petagrams (Pg) per year) (1 Pg = 1 gigaton = 1015 g). Dissolved CO2 (passively entering the ocean via diffusion from the atmosphere) has already acidified the surface ocean, the most productive region of the ocean. Ocean carbon sequestration (OCS) is a method to distribute CO2 more evenly throughout ocean depth and minimize surface ocean impacts. There are two major methods of OCS – direct injection and ocean fertilization (promoting photosynthetic fixation of CO2 by ocean organisms). This chapter focuses only on the direct injection as a method of OCS. This chapter will first describe the physical mechanism by which CO2 can be stored in the ocean water column at depth. It will summarize past ocean direct injection studies, and outline the effects of increased dissolved CO2 and locally increased CO2 partial pressure on marine organisms. It will also include a discussion of the engineering challenges of delivering CO2 to the water column, including the selection of injection sites to minimize CO2 outgassing to the atmosphere as well as minimizing marine life impacts. Finally, this chapter will address the legal, policy and public outreach issues that have ultimately precluded implementation of OCS using direct injection.
The ocean is presently the largest sink of atmospheric CO2 (about 7 Pg per year) [1]. The Earth’s oceans cover over 70% of the Earth’s surface, and have an average depth of 3,800 m. However, dissolved CO2 is already causing surface ocean acidification (most productive region of ocean) as it equilibrates with the atmospheric CO2[2]. By 1994, the total atmospheric release of anthropogenic (i.e., man-made) carbon was about 244 Pg of carbon (PgC) from fossil fuel combustion, and about 140 PgC from land use change (e.g., deforestation) [3]. The oceans have absorbed about one-third of anthropogenic CO2 (the atmosphere retained about 43%, while the oceans absorbed about 30%), leading to a decrease of surface-ocean total pH by about 0.1 units from about 8.2 to 8.1. If CO2 emissions continue unabated the subsurface ocean total could decline by 0.7 units by 2300. To place in a geological perspective, the surface ocean pH (on a total scale) has not been below 8.1 during the past 2.1 million years. The total addition of carbon into the atmosphere is expected to be about 5000 PgC – the estimated fossil fuel reserves excluding hydrates -- in the next 500 years. This is a higher rate of carbon addition than ever experienced by the earth over a short geological time scale [3].
At the same time the ocean pH in the deep ocean has been decreasing at a relatively slower rate compared with the surface ocean [1, 4]. Rising concentrations of greenhouse gases in the atmosphere are implicated in adverse climate changes and two-thirds of the change is attributed to CO2 [1]. Ocean carbon sequestration was conceived as a method to distribute CO2 more evenly throughout the ocean column, especially into deep ocean waters, and minimize surface ocean impacts while the ocean CO2 levels equilibrate with the atmosphere.
There are two major methods of OCS – direct injection and ocean fertilization (promoting photosynthetic fixation of CO2 by ocean organisms). This chapter focuses only on the direct injection of CO2.
The conditions under which CO2 can exist in a gas, liquid, solid or hydrate, and aqueous phases are depicted in the phase diagram (see Figure 1) [5] At typical ocean temperatures and pressures, CO2 exists as a gas above 500 m depth, and a liquid below this depth. Between 500 and 2700 m depth, liquid CO2 is less dense than seawater and would float, while below 2700 m CO2 is denser than seawater and would sink. A solid CO2 hydrate phase is thermodynamically stable in the ocean at low temperatures; CO2 hydrates are discussed in Section 2.3.
CO2 dissolves in ambient seawater that is not saturated with CO2. Once dissolved, aqueous CO2 exists in various charged forms in water according to these main reactions, known as the carbonate system [6]:
The total dissolved inorganic carbon (CT) is defined as:
Phase Diagram for CO2 in the ocean [
The result of this is that increasing dissolved CO2 will shift the equilibria (1) and (2) above to the right, and lower the local pH of the ambient seawater. [7]. At a typical surface seawater water pH of 8.2, the equilibrium (3) is shifted to the left with the addition of CO2. The net result of an increase in dissolved CO2 is the decrease of pH, an increase in HCO3- and a decrease of CO32- (Figure 2).
In turn, the dissolved CO2 causes an increase of the density of the seawater via the solute density effect [9] that has implications for the physical design of a direct injection of CO2 into the ocean.
The partial pressure of CO2 of a sample of water, denoted by pCO2, is the pressure of gaseous CO2 which, if allowed to equilibrate with water, will result in the same amount of dissolved CO2 as observed in the sample. It is related to the solubility of CO2, Cs, and the concentration of H2CO3(aq) by the following:
where Cs(T,S) (usually expressed in μatm) is dependent on the local temperature T and salinity [10] provide empirical relations to obtain Cs.
Bjerrum (pHT (total scale pH) – relative speciation) plot showing the relative contributions of CO2, HCO3- and CO32- to the dissolved inorganic carbon as a function of pH, at 15 deg C and a salinity of 35 PSU. The dashed vertical lines indicate the average open ocean surface pHT during the Last Glacial Maximum (LGM), 1766, 2007 and 2100 (projected) [
As the atmospheric CO2 concentration increases, pCO2 levels increase in the surface ocean as it equilibrates with the atmosphere. The ratio of the relative change in pCO2 to the relative change in CT is known as the Revelle factor, and is inversely proportional to [CO32-]. The inverse of the Revelle factor is also often termed as the buffering capacity of the ocean. According to this relation, a doubling in atmospheric CO2 would only increase the total dissolved CO2 by about 10%. [11]
While sea-air equilibria for most gases like oxygen occur over a time scale of days, it can take ~8 months for CO2 to reach equilibrium at the surface, because the dissolved CO2 in the carbonate system does not remain a dissolved gas but instead causes an increase in HCO3-. [4].
The CaCO3 saturation state of seawater is defined as Ω:
where [Ca2+] and [CO32-] are the seawater concentrations of Ca2+ and CO32-, and Ksp is the solubility product of either calcite or aragonite (the two major forms of CaCO3). If Ω for aragonite (Ωa) for instance is greater than 1, then aragonite is supersaturated and solid aragonite would begin to precipitate; if Ωa drops to below 1 then aragonite is undersaturated with respect to the ambient ocean and solid aragonite would begin to dissolve. Because Ksp increases with pressure, for both aragonite and calcite there is a transition of the saturation state from Ω > 1 to Ω < 1 sediments with depth [3]. The depth at which Ω = 1 for a mineral is known as its saturation horizon.
CO2 sequestration first involves capture from their sources, of which one major type of the coal-fired power plant. The CO2 emissions are relatively pure from coal-fired power plants and could be isolated and injected into the ocean. A typical 500 MW power plant produces about 130 kg/s of CO2. [12]. After CO2 capture, the CO2 would be transported to the ocean via a pipe or ship to the ocean for direct injection. Technologies for CO2 direct injection include: Liquid CO2 droplets [13]; CO2 laden seawater [9,14,15]; Solid CO2 (dry ice) [16,17]; and CO2 lake formation (See Figure 3)
Ocean storage strategies (From Goddard, in [
As shown in Figure 1, at lower temperatures (below about 5 - 10 degrees C) and at high pressure (corresponding to an ocean depth of about 400 m or greater) solid CO2 hydrates are thermodynamically stable. CO2 hydrates consist of molecules of CO2 inside a cage-like structure of hydrogen-bonded water molecules [18]. They are of interest as a possible vehicle for deeper ocean carbon sequestration, because they are denser than seawater, and will sink unaided while dissolving to promote dispersion in the ocean. Pure hydrate particles are difficult to produce, but the Oak Ridge National Laboratory (ORNL) has designed a continuous CO2-seawater co-flowing injector to create cylindrical composite particles comprised of CO2 hydrate (negatively buoyant), liquid CO2 (slightly positively buoyant at 1000-1500 m depths) and seawater [19].
Although CO2 hydrates are thermodynamically stable, they will dissolve in ambient seawater upon release, because CO2 is under-saturated in the ambient water. Field and laboratory observations confirmed that both pure hydrates and partially reacted cylindrical composite particles dissolved in the ambient seawater [20,21,23].
Numerical efforts to simulate the behaviour of CO2 droplet plumes have included solving the full three dimensional Navier-Stokes equations in quiescent ambient sea conditions [7,22,24]. Bubble plume models calibrated using laboratory observations have also been applied to CO2 droplet releases [25-27].
Field tests were conducted using CO2 hydrate composite injectors [23,28]. The latest survey, with a hydrate reactor located at an ocean depth of ~1500 m, produced curved negatively buoyant cylindrical particles with diameters ~2.2 cm and lengths up to ~1 m. Applying a drag coefficient model to observed initial settling velocities and dissolution rates during the most recent survey [29,30], the hydrate conversion efficiency (percentage of liquid CO2 converted to hydrate) in the field was ~ 15-20% resulting in particles with specific gravity 1-2% greater than seawater, which lead them to sink to a depth below discharge of roughly 100 m. Greater sinking could be achieved using larger particles. Discharging particles with a range of sizes and densities (reflecting different conversion rates) would cause differential settling resulting in spreading in the down-current and vertical directions. Furthermore, towing the source from a moving ship would contribute additional dispersion [29].
An alternative approach to enhancing mixing and vertical descent is to release a continuous stream of particles, forming a dense plume which would sink both due to the density of the particles as well as the increased density of seawater containing dissolved CO2. An integral double plume model [25,29,31] was used to simulate the behavior of continuous streams of composite particles released to a quiescent ocean, with typical ambient stratification, at CO2 loadings of 0.01 to 1000 kg/s. Results showed that, for a CO2 release of 100 kg/s (roughly the emission from a 500 MW coal-fired power plant), a plume composed of 2.2 cm diameter composite particles with 16% reaction efficiency would sink about 1000 m, approximately 10 times the individual particle sinking depth. A plume composed of similar particles, but with a diameter of 5 cm, would sink about 2000 m (~5 times the individual particle depth), while plumes composed of larger particles, or particles exhibiting higher reaction efficiency, would reach the seafloor (as would the individual particles).
Two ambient effects reduce the performance of a plume: stratification and ocean currents. Plume sinking is hampered by strong ambient stratification which causes trapping of entrained seawater at intermediate depths below release. Density stratification weakens at depths below 1500 m [32], so from the perspective of reduction of plume trapping, regions of the ocean deeper than 1500 m are potentially favourable for depositing CO2 [33].
Some of the concepts relevant to the impacts of OCS by direct injection (e.g. ocean acidification) are presented in this section. The reader is directed to [1,11] for a more detailed and comprehensive summary of the causes and effects of ocean acidification.
Investigations and estimation of the long term stability is described in greater detail in [1]. Numerical ocean models indicate that placing CO2 in the deep ocean would isolate most of the CO2 from the atmosphere for several centuries, but over longer times the ocean and atmosphere would equilibrate.
Relative to direct atmospheric release, direct injection of CO2 into the ocean could reduce the rise and peak of atmospheric CO2 levels over the next several centuries. After several centuries, the CO2 released in the ocean would be transported back to the ocean surface and interact with the atmosphere again. However, in the new equilibrium, most (66% to 85%) of the injected CO2 would still remain in the ocean despite contacting the atmosphere [1].
Generally, carbon injected in the deep ocean would equilibrate with the atmosphere over a time scale of 300 to 1000 years, based on radiocarbon and other tracer dating to estimate the age of the deep seawater. The estimated age of the North Pacific deep water is 700 – 1000 years, while the North Atlantic deep water is estimated to be only about 300 years old. A large number of numerical three dimensional ocean general circulation models were used to study CO2 retention. The models generally predict a higher retention time with a deeper injection depth (isolation of CO2 from the atmosphere is nearly complete for 100 years with an injection depth of 3000 m). Consistent with the radioactive tracer dating, many of the models suggest that the Pacific Ocean would retain a larger fraction than the Atlantic Ocean. However, the models vary greatly in their predictions on the actual time taken for CO2 injected at a particular site to once again make contact with the atmosphere [1, 34].
Additionally, other geochemical factors may affect these predictions. For example, a higher ocean temperature, as well as a higher dissolved inorganic carbon concentration may lead to a lower efficiency for the ocean to absorb additional CO2. (See [11]).
As described in Section 2.1, ocean acidification has been occurring since the Industrial Revolution. This section describes the effect of continued ocean acidification on the ocean’s carbon cycle and marine ecosystems. Between 1991 and 2006, North Pacific ocean pHT showed a decrease of 0.06 units over the upper 500 m of ocean. In the Iceland Sea, the trend of pHT decrease between 1985 and 2008 in the surface ocean was 0.0024 units per year, with a corresponding decrease in Ωa of 0.0117 units per year. The decline in pHT below 1,500 m in the Iceland Sea was one-quarter of that on the surface, with a corresponding decrease in Ωa at 0.0009 units per year [4].
Another consequence of the increased dissolved CO2 in the ocean, as described in Section 2.1.1, is the increase of HCO3- and a decrease of CO32- in the ocean. The decreased CO32-in turn leads to the decrease of the local value of Ω in the ocean. As there is a transition from saturation to undersaturation from Ω = 1, this means that the saturation horizons for both aragonite and calcite would both become less deep with time [3]. The decrease in Ωa caused the aragonite saturation horizon (ASH), the interface between supersaturated waters above and undersaturated waters below, to rise (shoal) at a rate of 4 m per year. The decrease in Ω, and therefore the shoaling rate for the ASH, is predicted to be more pronounced near the poles, and more severe in the Arctic Ocean than the Southern Ocean, partly because the polar oceans have lower initial concentrations of CO32- [4].
It was proposed [3] that the addition of CO2 followed by global increase in surface temperature can be compared to that which occurred during the Paleocene-Eocene Thermal Maximum (PETM, ~55 million years ago). During PETM, about 3000 PgC was added to the over an estimated 6000 years. However, the current estimate for expected total anthropogenic carbon addition is a larger rate of carbon input over a shorter period of time, about 5000 PgC over about ~500 years. The next highest global carbon addition was experienced by the earth during the Paleocene-Eocene Thermal Maximum, (~55 million years ago) where about 3000 PgC was added over ~6000 years. During the PETM, the effects of ocean acidification on surface calcifying organisms was limited, but the conditions of the PETM were not identical to the predicted future scenario, notably in that the carbon input rate was still much slower than the modern anthropogenic carbon addition. Nevertheless, studies of the PETM may inform future predictions of the behavior of ocean marine life with a large increase of atmospheric CO2. [3,4].
Effects of elevated CO2 levels and acidified seawater on marine organisms are explained in in more detail in [1,11,35,36].
At acute levels CO2 has a narcotic effect on animals and causes respiratory distress and death. The work of [37 – 41] that model the lowered pH on passive marine organisms such as zooplankton that spend varying times in and out of a CO2 plume, and found that minimizing the local dissolved CO2 and pH drops will reduce the mortality rate.
Non-lethal effects have also been observed due to hypercapnia (elevated CO2 exposure) [42-44]. Tamburri et al. [42] have observed the narcotic effects of increased CO2 levels on mobile deep sea animals in the field; they also observe that while many tend to avoid CO2 plumes, some may risk the narcotic effects to obtain food. They note [42] that increased partial pressure of carbon dioxide will also have a detrimental effect on marine organisms, such as causing slow respiratory distress and inducing a narcotic effect on fish. Passive marine animals may experience depressed ion exchange capability and metabolism when exposed to lower, chronic levels CO2. Some studies also show slowed growth in mussels and corals, as well as developmental effects on some marine larvae and eggs (brittle stars and bivalves) [35].
The primary effect of acidified seawater exposure by organisms is acidosis, the decrease of pH in body fluids. Intracellular and extracellular processes have been shown to be disrupted when seawater pH drops to a range of about 6.0 – 7.8. Many marine animals counter acidosis by increasing bicarbonate ion production (e.g. in the gills) [35]. Barry et al. report that organisms that have weaker control of their internal fluid chemistry, and that rely on passive molecular diffusion for gas exchange such as sponges, echinoderms, may have greater sensitivity to ocean acidification [45].
Some organisms may adapt to hypercapnia (elevated CO2) better than others [46]. For example, tropical fishes, as they live closer to the edge of oxygen limitation than temperate fishes, may make them more sensitive to the combined effects of ocean temperature and ocean acidification than their temperate counterparts. For example, studies on acutely exposed tropical cardinal fishes to 1 week of pCO2 of 1000 μatm resulted in decreases of aerobic scope and critical swimming speeds by about 40 – 50%, but a similar study conducted for Atlantic cod after 12 months of exposure to both 3000 and 6000 μatm did not result in any significant change in swimming capacity.
High CO2 levels (up to a pCO2 of 16,000 ppm [47] have also been observed in ocean bottom waters and marine sediments where there are high rates organic matter oxidation and low rates of mixing with the overlying seawater. Under these conditions, high CO2 concentrations are often accompanied by low O2 concentrations. Near the surface at night, respiratory fluxes in some relatively confined rock pools of the intertidal zone can produce high CO2 levels. [1]. Portner et al. [46] report that high pCO2 is found in oxygen minimum layers. They report that elevated pCO2 is linked to acid-base regulation and respiration in fish. However, they also report that coastal and mid-water animals (both pelagic and benthic) regularly experience a large range of pCO2 values (500 to 9400 μatm) in estuaries [46]. “These patterns suggest that in some environments, organisms have evolved to tolerate relatively wide pH oscillations and/or low pH values.” [1]
Organisms such as the Humboldt squid, although thought not to be able to adapt physiologically to future changes to the oceans oxygen balance, have been observed to thrive in oxygen minimum layers which tend to have low pH and are undersaturated with respect to calcium carbonates [46].
Deep sea ecosystems depend on sinking particles of organic carbon, made by photosynthesis near the ocean, settling down through the water. Most species living in the deep sea display very low metabolic rates [48, 49], especially in oxygen minimum layers [51]. Organisms living in the deep seawaters have adapted to the energy limited environment by conserving energy stores and minimizing energy turnover. Turley et al. also suggest the depletion of oxygen as a contributing factor to the increased prevalence of harmful algal blooms, though the link between anthropogenic CO2 and algal blooms remains controversial [36].
Finally, as many marine organisms synthesize and depend on calcium carbonate structures (e.g. shells), the implication of a lowered CO32- and Ω in the ocean is the potential for reduction of their habitats.
As a guide, [1] uses a pH drop of 0.1 units as the threshold pH drop for insignificant marine life impact; it is also within the observed natural variability in the ocean. The US Environmental Protection Agency proposed that the threshold for open waters at depths greater than the euphotic zone, the pH value should not drop more than 0.2 pH units outside the range of natural variation [11]. [39] shows that some theoretically modeled scenarios of carbon dioxide releases (for example, releasing sinking CO2 hydrates from a fixed or moving source at 1,500 m, injecting 10 to 1000 kg/s) would result in local pH drops within this guideline threshold in the vicinity of the release point. Others (e.g. Rockstrom et al.) have introduced the concept of planetary boundaries, and for CO2 they have proposed a threshold carbonate ion concentration. As a first estimate, they proposed that the oceanic aragonite saturation state Ωa be maintained at 80% or higher of the average global pre-industrial surface seawater level of 3.44 [50]. As with [1], these planetary boundaries are guides for a sustainable global environment, and (with the exception of the US Environmental Protection Agency for pH) have not been implemented as a regulatory threshold.
In the ocean, hydrothermal vents are submarine volcanic structures that act as natural sources of CO2 in the ocean. These have been observed as potential natural analogues of OCS direct injection points. Field observations of hydrothermal vents have shown large fluctuations of pCO2 (up to 80,000 ppm), over 100 times that observed in typical deep seawater). Over time, the vents have sustained organisms that are specially adapted to living in elevated pCO2 conditions [52].
Observations near hydrothermal vents have shown that ocean acidification reduced biodiversity below a mean pHT of 7.8 [53]. While Echinoderms are notably absent from habitats with naturally high CO2 levels such as hydrothermal vents and shallow CO2 vents off the coast of Italy [53], sponges appeared to tolerate these same sites.
As observed in [45], “[h]owever, while commonly the literature contains results of short term studies of organism physiology and survival, they may not be indicative of eventual long term consequences of ocean acidification.”
As described in [1,54], to date there are no publications dedicated to site selection for direct ocean injection. Although numerical models have predicted CO2 retention time as a function of the injection location, they have not consistently agreed on any individual location for direct injection. The only agreement appeared to be that a larger depth of injection would result in a longer isolation of CO2 from the atmosphere [34]. In contrast, [55] presented a study of site selection for deep sea geological storage, highlighting the potential of storage in basalt aquifers along particular seismic and aseismic oceanic ridges. This section therefore discusses factors that should be considered site selection criteria based on to be considered when selecting a site for OCS. Environmental goals of site selection include reducing the likelihood of outgassing, and minimizing acute impacts to ocean organisms, as described in Section 3. Additional considerations include the costs of OCS, applicable international policies (such as regulations regarding disposal and cross border transport) – these factors are presented in Sections 4.2 and 4.3.
Costs were estimated for ship transport of liquid CO2 to an injection platform, with CO2 injection from a vertical pipe, or a ship trailing an injection pipe, to water at 3000m [1]. The cost estimate of ocean storage is the sum of three major components: tank storage of CO2 onshore awaiting shipping; the shipping of CO2; and direct injection of CO2 into the ocean (either via an ocean platform, a moving ship, or a pipeline). The estimated sum of the three components (including an assumption of 3% CO2 emissions from boil off and fuel consumption) is 11.9 and 13.2 US$/ton CO2 net stored from shipping to 100 km and 500 km offshore, respectively [56]. Cost estimates presented do not include transport of CO2 onshore.
The cost for transporting CO2 from a power plant located at the shore through a pipeline running on the sea floor to an injection nozzle was also estimated in [56]. CO2 captured from a pulverized coal fired power plant with a net generation capacity of 600 MWe is transported either 100 or 500 km by a CO2 pipeline for injection at a depth of 3000 m at a cost of 6.2 US$/ton CO2 net stored (100 km case) to 31.1 US$/ton CO2 net stored (500 km case). Other technical challenges that may not be accounted for include: residual chemicals, metals, minerals and oils that may be released during drilling activities; and the fact that liquefied CO2 is highly corrosive, requiring that piping for CO2 delivery would require anti-corrosion coatings, which themselves may pose contamination issues [35].
There are no published cost estimates specific to the production of a CO2 lake on the sea floor; however, given the dominance of pipeline costs, it is reasonable to assume it to be similar to deep water injection. [1,56].
Since offshore OCS is likely to take place in international waters, several international environmental agreements may apply, mainly those that aim to minimize potential risk s to the marine environment. The main international treaties are the Law of the Sea, the London Convention, London Protocol, and the OSPAR Convention. A succinct background of these treaties is taken directly from [57]:
“International marine environment protection was established in 1972 with the London Convention to regulate the dumping of wastes and other matter at sea. In 1982, this field was extended through the adoption of the United Nations Convention on the Law of the Seas (UNCLOS). Being an overarching construction, UNCLOS does not contain detailed operative provisions on most maritime issues; rather, it provides a framework for all areas, including marine protection, and allows other, more targeted treaties to fill in the gaps…With regard to marine pollution, global standards are set by the Convention on the Prevention of Marine Pollution by Dumping of Wastes and other Matter, signed in London in 1972 (London Convention). Beneath the London Convention exist several regional agreements that cover specific areas of the ocean [Also listed in [57]]. The most widely known of these is OSPAR, the Convention for the Protection of the Marine Environment of the North-East Atlantic. OSPAR is also notable as its regulations on marine pollution are markedly stricter than those of the London Convention, and its decisions are legally as opposed to politically binding on its Contracting Parties.”
UN Convention on Climate Change encouraged the use of the oceans as a reservoir for CO2, but the UNCLOS (in force since 1994) did not give clear guidance on OCS [1]. With respect to CO2 storage, the original London Convention (with 80 contracting parties, and in force since 1975) only applied to storage by aircraft and vessels and platforms in the water column. As a result, the London Convention did not apply to storage of CO2 in the seabed or the water column itself [57].
In November 1996, the London Protocol was established that prohibited the disposal of “industrial waste” into international waters. The list of prohibited substances that were categorized as “industrial waste” were contained in Annex I of the London Protocol. However, in 1996 the London Protocol did not give an opinion whether CO2 was categorized as a “waste material generated by manufacturing or processing operations” [1]. The London Protocol entered into force March 2006 [57].
In 1992, the OSPAR Commission for the Protection of the Marine Environmental of the North-East Atlantic, was formed which unified the 1972 Oslo and 1974 Paris Conventions. It brought together the governments of Belgium, Denmark, Finland, France, Germany, Iceland, Ireland, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom, together with the European Community (EC). It is considered the most comprehensive and strict legal framework governing the marine environment. As mentioned above, the contracting parties are legally bound to OSPAR’s decisions [57,58].
In June 2007, the OSPAR issued two amendments to the OSPAR Convention: the first, a decision to prohibit the storage of CO2 streams in the water column or on the sea bed in the Northeast Atlantic; and the second, a decision to allow the storage of CO2 in subsea sediments. [59,60]
In the first amendment, OSPAR stated that CO2 storage in the water column or on the sea bed “is not a sustainable storage option, is likely to result in harm to living resources and marine ecosystems and is thus neither a viable solution with regard to mitigating climate change nor compatible with the aims of the [OSPAR] Convention.” However, in the first amendment, OSPAR indicated that ocean storage of CO2 in the water column or on the seabed is nevertheless still under consideration in international forums. [59]
The OSPAR amendments provided a framework for its contracting national governments to develop permitting programs for CO2 storage. For example, a list of the minimum items required in an offshore CO2 storage permit included: a description of the project, including injection rates; types, amounts and sources of CO2; the location of the facility; characteristics of the geological formation; methods of transport; and a risk management plan, with monitoring and verification measures, mitigation steps and a site closure plan [60].
In July 2011 the contracting parties of the OSPAR Convention ratified the 2007 Amendments to allow for CO2 storage in subsea geological formations [58].
In 2007, an amendment to the London Protocol (Annex 1) allowed for storage of CO2, if the disposal is into a sub-seabed geological formation, if CO2 streams are “overwhelmingly” carbon dioxide, and as long as no wastes are added. This amendment provided that CO2 streams may only be considered if [60,61]:
disposal is into a sub-seabed geological formation;
they consist overwhelmingly of CO2. They may contain incidental associated substancesderived from the source material and the capture and sequestration processes used; and
no wastes or other matter are added for the purpose of disposing of those wastes or other matter.
The amendments to Annex 1 entered into force on 10 February 2007. In contrast to the OSPAR Convention Amendment that only covered the Northeast Atlantic, the 2007 London Protocol Amendment specifically prohibited direct injection of CO2 for OCS for all London Protocol contracting parties.
Article 6 of the London Protocol (on the export of wastes or other material) was largely interpreted by the contracting parties as prohibiting the export of CO2 from a contracting party for injection into sub-seabed geological formations. In 2009 Article 6 was amended to allow for cross-border transportation of CO2. [61]
As of 2011, there were 40 contracting parties to the London Protocol. Of these parties, 27 must also accept the 2009 amendment to Article 6 for it to enter into force. However, not all of the parties have been interested in offshore CO2 storage or cross-border movement of CO2, and have placed the ratification of Article 6 as a low priority. Cross-government cooperation will probably be required for ratification to occur. In some countries, the ratification may also be pending other laws and regulations that need to be changed for carbon storage and sequestration in general [61].
Therefore, although geological carbon sequestration in the ocean has been approved in principle the OSPAR Convention and even the London Protocol, the Article 6 amendment may continue to pose a policy barrier to OCS deployment in the foreseeable future.
It is noteworthy that no field studies demonstrating OCS at a significant scale have been conducted so far prior to its prohibition through the 2007 London Protocol and OSPAR Convention amendments. The largest scale attempt at demonstrating OCS was the Hawaii CO2 direct injection experiment This section outlines the failure of the Hawaii experiment mainly fuelled by a lack of early public outreach, and outlines some lessons learnt from the Hawaii project. [62,63]
In 1997 the US Department of Energy, the New Energy and Industrial Technology Development Organization of Japan (NEDO) and the Norwegian Research Council (NRC) signed an agreement to conduct experiments to evaluate the behaviour of liquid CO2 releases in to the ocean. While the project was announced in Kyoto in 1997, with a high profile to demonstrate the sponsors’ commitment to CO2 mitigation, few resources were subsequently invested in public outreach.
The project scientists and sponsors selected an area off the coast of the Big Island of Hawaii to conduct the pilot CO2 study, based on technical feasibility and existing research infrastructure. However, they did not gauge the public perception prior to site selection. The local population only learnt of the injection project planned in their waters when it was first published in a newspaper article. In an area where the ocean is viewed as a major natural resource, the public perceived of the “dumping” of CO2 as a violation, and strongly opposed its continuation.
Eventually the pilot injection project was abandoned in Hawaii. In order to salvage the project, scientists attempted to instead conduct an injection study in Norway. However, here the actions of Greenpeace stopped any further testing, thus precluding completely any chance of field scale testing of direct-injection OCS.
Although the introduction of OCS was initially high profile the sponsors’ commitment to CO2 mitigation, few resources were subsequently invested in public outreach. Moreover, the sponsors largely did not include the public in their decision to site the pilot injection experiment in Hawaii, nor did they factor public perception of potentially conducting a CO2 injection experiment in an area where the ocean is viewed as a major environmental resource.
Reiner (2008) cited the US National Institute of Standards and Technology (NIST) 2002 workshop for “Best Practices for Communication of Science and Technology to the Public” as a resource that offered key recommendations for public outreach, including:
Illustrating both the scientific process and unresolved scientific questions, rather than showing a result based on a black box model
Using scientists in a public education role for a range of audiences (children and adult)
Incorporating a wide source of knowledge from others so as to avoid parochialism
Presenting the issues from the audiences’ point of view
Using face-to-face communications whenever possible to foster trust
Reaching out beyond the science-attentive public, e.g. presenting at shopping malls, to disadvantaged youth
Using multimedia and illustrations
Providing press releases in forms easily usable to time-strapped journalists
Avoiding perceptions of environmental injustice, bias or conspiracy
Including the public from the start to avoid charges of “sneaking up on us” or less than full disclosure
Avoiding letting the project become a “political football” by creating vocal supporters within the community
In addition, Reiner suggested that early outreach to the public via the internet during developmental stages of a project is important before the project becomes newsworthy and receives attention from mainstream media outlets. [63].
The lack of outreach is reflected in the low level of understanding that has remained among the public, as well as relatively low public acceptance of carbon capture and sequestration (both geologic and ocean). Reiner summarized the European Commission’s survey of the public from 25 countries of the European Union (the Eurobarometer) that showed that, in 2007 (at the same time as the OSPAR convention and London Protocol amendments), only 21% of those surveyed have heard of carbon capture and storage (geologic or ocean), compared with 53% for hydrogen energy and cars, 41% for fuel cells, and 44% for geothermal energy [63]. In the US in 2004, only 2.5% of 1200 respondents in a web-based survey had previously heard of carbon sequestration. In 2007, Palmgren et al. surveyed 126 community respondents, who ranked OCS less favourable than geological carbon sequestration. Both carbon sequestration options were less favourable to the respondents than nuclear power [64].
Whether CO2 is introduced intentionally, or passively diffusing from the atmosphere to the ocean, the ocean is and will remain the largest sink of anthropogenic CO2. In addition to climate change implications of elevated atmospheric CO2, a further impact is the acidification of the ocean. Effects of increased acidity and pCO2 in organisms include respiratory distress (but some deep sea organisms take advantage of the CO2/O2 balance). There is also a risk of a reduced habitat as calcium carbonate stability zones decrease. However, further study is required to determine the variability of responses among marine species.
This chapter presented several methods by which direct injection of CO2 into the ocean could be introduced. Some injection technologies were developed that would theoretically, combined with proper siting of injection points, cause a relatively minor impact to marine ecosystems. Some pilot scale field studies began that would have provided more information about environmental impacts, but they were nixed due to public opposition stemming from a lack of extensive and continuous public outreach from the onset. Since 2007, international policies began to prohibit direct discharge of CO2 into the ocean, while favouring deep sea geological sequestration. CO2 leaks (e.g. in the form of droplets [65]) from geological structures to the ocean water column are however still possible [35], so continued research and studies about the mechanisms of CO2 leakage and the effects of increased dissolved carbon in the ocean continues to be an important topic of study for carbon sequestration.
This chapter contains work funded by Ocean Carbon Sequestration Program, Biological and Environmental Research (BER), U.S. Dept. of Energy (grant number DE-FG02-01ER63078), the National Energy Technology Laboratory, U.S. Dept. of Energy (grant number DE-FG26-98FT40334) and the Martin Family Fellows for Sustainability.
In invertebrates, one ancestral gene, DAF-2, encodes one receptor that binds insulin-like peptides [1]. With the emergence of vertebrates, three distinct receptors appeared, namely: the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF1R), and an orphan receptor called the insulin receptor-related receptor (IRR). The genes encoding these receptors share similar genomic organization, with conserved α and β protein chains that are synthesized from one single pre-mRNA (reviewed in [2]). While originally all three receptors were formed by 21 exons, both IRR and IR acquired independently one extra exon, namely exon 11. The IRR exon 11 can be traced back to amphibians, whereas IR exon 11 is found exclusively in mammals [3, 4]. Thus, exclusively in mammals, the exon 11 of the IR gene is alternatively spliced to produce two protein isoforms called IR-A and IR-B. To trace the origin of IR isoforms, Hernández-Sánchez et al. analyzed their transcripts in different species by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis [4]. In mouse tissues, they found tissue-specific expression of both IR-A and IR-B, while in chicken and frog tissues, only the IR-A isoform was detected [4]. The physiological reason for the evolutionary acquisition of the IR-B isoform in mammals is unclear. It seems that the IR-B provided the receptor with higher specificity for insulin and poor binding of other possible ligands of IR-A, which will be discussed later.
In humans, the insulin receptor gene (INSR) maps to human chromosome 19 (in mice, it maps to chromosome 8) and spans more than 120 kb [5]. The insulin receptor complementary DNA (cDNA) was cloned in 1985 by two independent groups [6, 7], giving two different lengths and indicating two isoforms, dependent on the inclusion (IR-B) or exclusion (IR-A) of exon 11. The 36 base pairs of exon 11 (that account for the 12 amino acid difference) encode a portion of the C-terminus of the α-subunit in the vicinity of the ligand-binding domain (reviewed in [8]), resulting in isoform-specific properties of the receptors. A linear α-β amino acid sequence (IR pro-receptor precursor) is translated from the IR mRNA and includes a signal sequence at the N-terminus to enter the endoplasmic reticulum [9]. After cleavage of the signal peptide, the inter-α-chain disulphide dimerization occurs, forming the β-α-α-β structure of the IR [10]. The insulin pro-receptor is further processed in the Golgi apparatus by the protease furin, and the mature IR is then trafficked and inserted in the plasma membrane [11].
The IR and IGF1R belong to the same subgroup of receptor tyrosine kinases and can form either homo-receptors (two IR α-β subunits) or hybrid receptors, consisting of one IR α-β subunit linked to one IGF1R α-β subunit. Furthermore, the two IR splice variants enable the formation of both homo-dimers (IR-A/IR-A) or hetero-dimers (IR-A/IR-B), and similarly, two modalities of hybrid receptor (IR-A/IGF1R and IR-B/IGF1R). Hybrid receptors have been detected in all tissues and cell lines that express both receptor types [12] and it is presumed that both IR-A and IR-B isoforms are equally capable of forming hybrids with IGF1R [13]. The factors regulating their assembly are unknown; however, there is evidence to suggest that the formation of homo-receptors and hybrid receptors is proportional to the relative concentrations of each receptor type [12, 14, 15].
Crystal structures of the IR were determined in 1994 [16] and 2006 [17] and refined in 2016 [18]. Single-particle cryo-electron microscopy has since been used to explore receptor conformations and ligand-receptor complexes [19, 20, 21]. It is worth pointing out that these studies used the IR-A isoform to reconstruct and represent the IR. The functional IR consists of two covalently linked IR monomers, that is, two extracellular α-subunits linked by disulphide bonds and two transmembrane-spanning β-subunits. The α-subunit contains either 719 (IR-A) or 731 (IR-B) amino acids and has a molecular mass of approximately 130 kDa. This subunit is entirely extracellular and contains the ligand-binding sites. The transmembrane-spanning β-subunit contains 620 amino acids, has an approximate molecular mass of 95 kDa and is composed by extracellular, transmembrane, and cytosolic domains. The latter domain contains the receptor’s tyrosine kinase, which is activated by ligand-binding and conformational change of the IR. Two insulin-binding sites are located in the extracellular α-subunit of the IRs. The primary insulin-binding site (site 1) is formed from elements of the L1 domain and a C-terminal peptide of the α-subunit [22, 23, 24, 25, 26, 27]. The second insulin binding site (site 2) has lower ligand binding affinity and is formed from residues in the first and second type III fibronectin repeats [28]. A model for insulin binding to the IR has been showed, in which one single insulin molecule simultaneously engages site 1 of one α-chain and site 2 of the other, thus bridging the two IR monomers; while a second insulin molecule binds to the equivalent, symmetry-related site 1′, creating a second bridging with site 2′. The two insulin molecules effectively crosslink the two IR monomers and thereby activate the IR [8, 20, 21]. As to the possible implications of the differences in the α-chain C-terminal domains of the IR isoforms, comprehending the significance of the 12 extra amino acids is hampered by the lack of structural data using the IR-B isoform. Thus, only secondary structure predictions can be made. It can be inferred that the 12-amino acid fragment of IR-B is most certainly the reason for the lower binding affinity of insulin-like growth factor 1 (IGF1) and insulin-like growth factor 2 (IGF2) toward this receptor isoform in comparison to IR-A (as discussed in Section 2.2). Based on this, Menting et al. speculate that the additional residues in the IR-B α-chain C-terminus are devoid of secondary structure, thus making this structure longer and hindering steric accommodation of these ligands, with a similar situation to be expected regarding insulin binding [29]. Whittaker et al. used alanine-scanning mutagenesis of insulin binding site 1 of IR isoforms A and B transiently expressed in cells to study their insulin binding properties [30]. They found several mutations that compromised insulin binding, some of which produced differential effects between the two receptors, either reducing affinity or inactivating one specific isoform [30].
The different structures of the IR isoforms are responsible for their functional differences, for example, disparity in ligand affinities, internalization and recycling kinetics, signal transduction, and the activation of specific cellular pathways.
Insulin is the main ligand for the IR, although the receptor also binds IGF1 and IGF2, as well as proinsulin (hormone precursor to insulin) (Figure 1). Some groups set out to study the different ligand binding affinities of the IR isoforms and came to different conclusions. To measure isoform-specific ligand binding, the main technique used throughout the different studies was competition for radiolabeled insulin. All studies were conducted using human IR cDNA in mouse or rat cell lines (referred to as hIR-A and hIR-B), probably aiming to translating the findings in humans. Mosthaf et al. expressed hIR-A and hIR-B in Rat-1 cells and found that IR-A had ~2-fold higher affinity for insulin than IR-B, both in intact cells and using detergent solubilized, partially purified receptors [31]. In agreement, Kellerer et al. used partially purified receptors from Rat-1 cells and found that IR-A displayed a higher affinity for insulin compared to IR-B [32]. Accordingly, Yamaguchi et al. also reported a ~2-fold higher affinity for insulin in intact Chinese hamster ovary (CHO) cells expressing hIR-A, in comparison to those expressing hIR-B [33]. A second study by this group found a faster insulin association rate to hIR-A receptors in intact CHO cells, as well as an accelerated insulin dissociation from hIR-B receptors, proposing a biochemical basis for the differential ligand biding affinities [13]. A similar faster dissociation of insulin from hIR-B that could be responsible for the lower affinity of this receptor was shown for Rat-1 cells [34]. To note, contrarily to all studies that used stimulated native receptors on intact cell membranes, a single work using solubilized recombinant receptors found no significant difference between the affinities of the two IR isoforms for insulin [30].
IR-A, IR-B, and IGF1R monomers, and their combinatorial possibilities of dimerization, with their possible ligands. The size of the different ligands represents the relative affinity for a given receptor. IGF1, insulin-like growth factor 1; IGF1R, type 1 insulin-like growth factor receptor; IGF2, insulin-like growth factor 2; IR, insulin receptor; IR-A, insulin receptor isoform A; IR-B, insulin receptor isoform B.
IR isoform affinities for IGF1 and IGF2 have also been investigated. Frasca et al. used R-cells, a mouse fibroblastic cell line that lack IGF1R, expressing either hIR-A or hIR-B [35]. They reported that IR-A, but not IR-B, binds IGF2 with high affinity (comparable to that of insulin). Further, IGF2 bound to IR-A with similar affinity to that of IGF2 to IGF1R [35]. Using the same cellular system, Sacco et al. reported that IR-A bound IGF2 with high affinity (4-fold lower than that for insulin), whereas IR-A’s affinity for IGF1 was 30-fold lower than that for insulin [36]. Proinsulin binding has been less studied compared to the other ligands and its ability to bind differentially the two IR isoforms as well as its possible signal transduction remain an enigma. One study in intact R-cells showed that proinsulin binds and activates both IR isoforms, but had a higher affinity for hIR-A than for hIR-B. Authors report that, similar to IGF2, proinsulin effectively stimulates cell proliferation and migration and curiously had no activity toward IGF1R or IR/IGF1R hybrid receptors [37]. Conversely, McClain’s work (mentioned previously) conducted in intact Rat-1 fibroblast cells found that hIR-A and hIR-B bound proinsulin with the same relative affinity [34].
Few studies have addressed the ligand affinities for the different hybrid receptors (IR/IGF1R). Using competition for tracer-labeled insulin and an enzyme-linked immunosorbent assay (ELISA)-based method, Slaaby et al. found that IR-A/IGF1R and IR-B/IGF1R hybrid receptors respond 20 to 50 times more effectively to IGF1 than to insulin [38, 39]. The increase in IGF1R expression and thereby its incorporation into hybrid formation with IR has prompted a potential role of hybrid receptors in reducing cell insulin responsiveness. Studies in CHO cells suggest that hybrids between IGF1R and both IR isoforms have low binding affinity for insulin and high affinity for IGF1 and IGF2 [40]. Another study in R-cells showed that IR-B/IGF1R receptors had high affinity only for IGF1, whereas hybrid IR-A/IGF1R receptors also bound IGF2 and insulin [41].
In summary, the accumulated knowledge suggests that IR-A has higher affinity for insulin, IGF1 and IGF2 compared to IR-B and that hybrid receptors show a preferential affinity for IGF1 (Figure 1). This could be due to the availability/inaccessibility of the different binding sites in hybrid receptors. The majority of these affinity studies were conducted using mainly tracer-labeled ligand technique and the works on binding affinity for insulin to IR-A/IR-B are dated more than two decades ago. Molecular chemistry methods have advanced since then and it could be of interest to verify these affinity studies with improved tools comparing primary cells (with double knockout of IR and IGF1R) where only one IR isoform (of the same species of the cells) is expressed at a time. Moreover, ligand binding could potentially be altered by different post-translational modifications of the α-chain such as specific glycosylation patterns and different lipid raft composition, which could both vary between cell types and under different culture conditions.
The IR isoforms seem to display equal receptor activation and kinase activity triggered by the binding of insulin. McClain et al. investigated insulin-stimulated tyrosine kinase activity in solubilized hIR-A and hIR-B receptors by exposure to insulin and radioactive ATP and found similar accumulated radioactivity in the Tyr-phosphorylated receptors [34]. On the contrary, Kellerer et al., preparing equal amounts of solubilized hIR-A and hIR-B, found higher radioactivity for hIR-B (2.5-fold) after stimulation with insulin and phosphorus-32 [32]. However, when performing the same experiment on native receptors in human embryonic kidney (HEK) intact cell membrane transiently expressing the isoforms, they detected no difference in tyrosine kinase activity. Neither did they report differences when they used short-time trypsinization to cleave the α-subunit and activate the tyrosine kinase [32]. The latter data suggests that solubilized receptors were able to undergo different activation compared to receptors integrated in the plasma membrane of intact cells, and that differences in the isoform α-subunit structures were responsible for their different kinase activities.
Few studies on the kinetics of IR isoform-specific internalization have been published. Yamaguchi et al. showed that in CHO cells expressing the isoforms, hIR-A displayed a 25% higher rate of ligand-stimulated internalization in comparison to hIR-B [33]. Further, work in Rat-1 fibroblasts showed that in cells expressing hIR-A, the maximum internalization reached ~65% after 10 minutes, followed by a high recycling rate of ~80% of internalized receptors after 20 minutes. In hIR-B expressing cells, the maximum internalization was ~60% and was reached within 15 minutes; however, no recycling was detectable within 30 minutes [42]. Clearly, these few data in specific cell lines warrants future research to dissect the different kinetics of internalization between the two IR isoforms.
Upon ligand-binding the IRs transduce diverse signaling pathways, which culminate in cellular functions ranging from glucose, lipid and protein metabolism to cell differentiation, proliferation and apoptosis. Insulin binding causes autophosphorylation and activation of the IR, which in turn allows the binding and activation of diverse downstream effectors. The availability and/or recruitment of specific binding partners could lead to distinct signal transductions and to the consequent activation of different pathways resulting in different biological endpoints/responses in different cell types. Up until now, only few cell types and IR isoform-specific signal transduction pathways have been investigated, especially in primary cells that express both isoforms. In the insulin-producing pancreatic β-cell, Leibiger et al. showed that the binding of insulin to IR-A or IR-B results in selective transcriptional activation of different target genes [43]. Insulin gene transcription was promoted through IR-A and the activation of PI3K class Ia/p70s6k-mediated signaling, while transcription of the glucokinase gene by signaling through IR-B PI3K class II-like activity and PKB [43]. In a subsequent study from the same group, Uhles et al. showed that isoform-specific insulin receptor signaling involves different plasma membrane domains [44]. By using tagged IR isoforms in a hamster β-cell line, they found that mutation of certain amino acids encoded by exon 11 resulted in both loss of signaling and shift in IR isoforms localization in the plasma membrane, suggesting an isoform-specific sorting to different microdomains of the plasma membrane [44]. Later, they demonstrated that spatial segregation allows simultaneous and selective signaling
In summary, the small 12 amino acid difference between the IR isoforms is responsible for the differences in their function in studied cells where both receptors are expressed simultaneously. Thus, it will be pivotal in future research to address and consider the existence and distinction of two IR isoforms when studying insulin signaling in specific cell types.
The IR isoform expression is regulated in a developmental and tissue-specific manner (Figure 2). In human, adult tissues associated with the known metabolic effects of insulin, such as the liver, adipose tissue but also kidney, IR-B is the predominant isoform [48, 49, 50, 51]. The IR-A isoform is highly expressed in fetal tissues—where it enhances the effects of IGF2 during embryogenesis and fetal development [52]—and in several adult tissues, such as brain [53], spleen [31], ovary [54] and testis [55]. The up-regulation of IR-A during adult life has been associated with mitogenic effects and has been described in a wide variety of cancers (reviewed in [56]). Other tissues express both isoforms in closer proportions, such as in pancreatic islets [57] and skeletal muscle [49]. Of note, IR isoform tissue distribution is generally conserved amongst mammals, with some differences, as shown in Table 1 [31, 50, 51, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73].
IR isoform expression in tissues and cell types. IR, insulin receptor; IR-A, insulin receptor isoform A; IR-B, insulin receptor isoform B.
Brain | Adipose tissue | Liver | Kidney | Spleen | Heart | Duodenum | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Species | Perigonadal | Mesenteric | Retroperitoneal | Subcutaneous | Bat | |||||||||||||||||||
Author | Year | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | |
Besic et al. | 2015 | H | 18 | 82 | ||||||||||||||||||||
Kaminska et al. | 2014 | H | 40 | 60 | ||||||||||||||||||||
Mosthaf et al. | 1990 | H | 40 | 60 | 50 | 50 | 100 | 0 | ||||||||||||||||
Seino and Bell | 1989 | H | 100 | 0 | 70 | 30 | 15 | 85 | 40 | 60 | 100 | 0 | ||||||||||||
Sesti et al. | 1994 | H | 45 | 55 | 15 | 85 | ||||||||||||||||||
Vienberg et al. | 2011 | H | 30 | 70 | ||||||||||||||||||||
Norgren et al. | 1994 | H | 25 | 75 | 10 | 90 | ||||||||||||||||||
Escribano et al. | 2009 | M | 40 | 60 | ||||||||||||||||||||
Vienberg et al. | 2011 | M | 95 | 5 | 22 | 78 | 25 | 75 | 38 | 62 | 5 | 95 | 5 | 95 | 95 | 5 | 60 | 40 | ||||||
Muller et al. | 2007 | M | ||||||||||||||||||||||
Moruzzi et al.a | 2021 | M | 95 | 5 | 15 | 85 | 20 | 80 | 6 | 94 | 6 | 94 | 8 | 92 | 88 | 12 | 73 | 27 | 18 | 82 | ||||
Huang et al. | 1994 | Mo | 95 | 5 | 70 | 30 | 35 | 65 | 70 | 30 | 60 | 40 | ||||||||||||
Vienberg et al. | 2011 | P | 95 | 5 | 85 | 15 | 90 | 10 | 80 | 20 | 18 | 92 | 50 | 50 | 80 | 20 | 30 | 70 | ||||||
Amessou et al. | 2010 | R | 95 | 5 | 8 | 92 | 30 | 70 | ||||||||||||||||
Serrano et al. | 2005 | R | 40 | 60 | 50 | 50 | 40 | 60 | 0 | 100 | 30 | 70 | 50 | 50 | ||||||||||
Vienberg et al. | 2011 | R | 95 | 5 | 22 | 78 | 60 | 40 | 30 | 70 | 65 | 35 | 10 | 90 | 18 | 82 | ||||||||
Vidal et al. | 1995 | R | 59 | 41 | 2 | 98 | 34 | 66 | ||||||||||||||||
McGrattan et al. | 1998 | S | 29 | 70 | 29 | 70 | 20 | 80 | ||||||||||||||||
Author | Year | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | |
Hribal et al. | 2003 | H | 50 | 50 | ||||||||||||||||||||
Malakar et al. | 2016 | H | 42 | 58 | ||||||||||||||||||||
Mosthaf et al. | 1990 | H | 80 | 20 | 90 | 10 | ||||||||||||||||||
Norgren et al. | 1993 | H | 30 | 70 | ||||||||||||||||||||
Sell et al. | 1994 | H | 18 | 82 | ||||||||||||||||||||
Norgren et al. | 1994 | H | 25 | 75 | ||||||||||||||||||||
Malakar et al. | 2016 | M | 35 | 65 | ||||||||||||||||||||
Vienberg et al. | 2011 | M | 55 | 45 | 80 | 20 | ||||||||||||||||||
Moruzzi et al.a | 2021 | M | 61 | 39 | 75 | 25 | 65 | 35 | ||||||||||||||||
Huang et al. | 1994 | Mo | 55 | 45 | 65 | 35 | ||||||||||||||||||
Vienberg et al. | 2011 | P | 20 | 80 | 20 | 80 | 20 | 80 | ||||||||||||||||
Serrano et al. | 2005 | R | 100 | 0 | 100 | 0 | 80 | 20 | ||||||||||||||||
Vienberg et al. | 2011 | R | 90 | 10 | 90 | 10 | ||||||||||||||||||
Vidal et al. | 1995 | R | 99 | 1 | ||||||||||||||||||||
McGrattan et al. | 1998 | S | 27 | 73 |
IR isoform mRNA expression in humans and animal models expressed as percentage of IR-A and IR-B.
Control for the high-fat high-sucrose diet in that specific study.
BAT, brown adipose tissue; EDL muscle, extensor digitorum longus muscle; GM, gastrocnemius muscle; H, human; IR, insulin receptor; IR-A, insulin receptor isoform A; IR-B, insulin receptor isoform B; M, mouse; Mo, monkey; P, pig; R, rat; S, sheep.
Because every tissue is composed of a mix of different cell types, findings regarding the expression pattern of IR isoforms cannot be extrapolated without considering the specific cell types forming the tissue. For example, analysis of liver tissue shows ~90% of IR-B expression, suggesting that hepatocytes may express exclusively IR-B. However, this tissue also contains other cell types, such endothelial cells which are known to express predominantly IR-A [70, 74], and Kupffer cells (the resident macrophages in the liver) in which IR isoform expression has not been studied. Another example is the brain, where tissue analysis shows mainly IR-A expression; however, predominant IR-B expression has been described in human astrocytes [75]. Regarding other primary cells, Muller et al. applied single-cell RT-PCR to elucidate IR isoform distribution in human pancreatic islet cells and, notably, found no expression of IR-B in isolated α-cells [69]. Mouse adipose tissue resident macrophages have been found to express both IR-A and IR-B, while mouse lymphocytes and monocytes express only a low amount of IR-B. Of note, these cells were analyzed as a bulk sample after magnetic-column cell sorting, with the possibility of low contamination of other cell types that might express IR-B [70].
IR-A is predominant in progenitor and precursor cells, whereas IR-B is more abundant in differentiated cells (Figure 2). Different studies reported high levels of IR-A in brown and white pre-adipocytes, osteoblast precursors, monocytes, neural progenitors and intestinal epithelial stem cells, compared with the high IR-B levels that characterize their differentiated cell counterparts [70, 72, 76, 77, 78, 79]. Some studies have reproduced this IR-A to IR-B switch favoring cell differentiation
In summary, the IR isoforms have specific tissue and cell-type distribution, and deviations from the wild-type IR-A/IR-B ratios may affect the fine-tuning of insulin signaling, disturbing metabolic and mitogenic pathways and compromising cell function.
Insulin receptor knockout (IR-KO) mouse models have been developed to study the function of the IR, and the reconstitution of IR signaling with only one type of receptor (IR-A or IR-B) has been exploited to understanding the distinct roles of the IR isoforms. Mice with a global deletion of IR are born with normal features and with only slight growth retardation. However, shortly after birth, metabolic control rapidly deteriorates, glucose levels increase upon feeding, and insulin levels rise up to 1000-fold above normal and the animals die of diabetic ketoacidosis within 48-72 h [52, 82]. This phenotype clearly indicates that the IR is necessary for postnatal glucose homeostasis but is not essential for prenatal growth.
Using IR-KO mice, Okamoto et al. demonstrated that lethality and diabetes in IR-KO mice could be rescued by reconstitution of IR-B in three organs: liver, brain, and pancreatic β-cells [83]. However, reconstitution of IR-B in only glucose transporter type 4 (GLUT4)-expressing tissues (e.g., muscle, fat) did not rescue the phenotype [84]. Their data suggests that insulin signaling in liver, brain, and pancreatic β-cells as insulin-target tissues is sufficient to prevent diabetes. The stable expression of either IR-A or IR-B in IR-KO tissue has been used as a platform by Benito’s group to study the differential role of the IR isoforms in the liver [85]. They developed adeno-associated viral vectors encoding IR-A or IR-B targeted to the liver and showed that hepatic expression of IR-A in inducible liver insulin receptor knockout (iLIRKO) mice could increase hepatic glucose utilization, thereby decreasing hyperglycemia and ameliorating the diabetic phenotype [85]. In another recent
To date, most of the research investigating the specific function of IR isoforms has been conducted in cell lines
A number of
In primary mammal tissues, with the tools at hand, changes in IR splicing have been studied at the transcriptional level during metabolic disease such as obesity and type 2 diabetes mellitus (T2DM), extrapolating changes to the protein level and thus signaling. During diabetes and obesity, several interesting studies addressed the possibility of splicing alteration of IR in human tissues such as muscle, liver and adipose tissue, which are accessible for sampling. Moreover, these tissues are primarily involved in insulin resistance and T2DM development, being the site of glucose handling and insulin clearance (liver), energy storage (adipose tissue) and the main site of postprandial glucose uptake (muscle).
In muscle, Norgren et al. found a poor correlation between IR-A mRNA and insulin-stimulated glucose utilization as well as an increase of IR-B in muscle tissue obtained from
Contrary to muscle tissue, one study in liver suggested that hyperinsulinemia can regulate the tissue ratio of IR mRNA favoring the IR-A isoform [63]. In this work, the authors measured IR isoform mRNA levels in liver samples from individuals with or without T2DM before gastric bypass surgery and after 1.5 years follow-up. They found that IR-A expression was higher in T2DM patients prior to surgery and that the abnormal liver IR-A/IR-B ratio normalized post-surgery in patients with remission of diabetes, following a decrease in IR-A expression [63]. Despite a limited sample size, a similar trend was shown in a previous study by Moller et al. [49].
In subcutaneous adipose tissue (SAT), Kaminska et al. found an increased IR-A expression in insulin-resistant, obese and T2DM subjects (compared to controls), which was reversed by weight loss [65]. Moreover, they found a correlation between high fasting insulin and IR-A, linking these alterations to possible changes in splicing factors, which would in turn regulate IR isoform expression. However, using a polyclonal antibody which can differently displace radiolabeled insulin from the two IR isoforms (used for studies in muscle as mentioned above [90]), a previous study in human isolated adipocytes showed an increase in IR-B expression in adipocytes of non-insulin-dependent T2DM patients [92]. Notably, this small cohort of patients had similar body mass index (BMI) values and insulin levels and were on different antidiabetic medications or under dietary intervention [92].
In mouse as well as in other mammals, several studies have addressed the amount of IR isoform transcripts in different organs in healthy animals (see Section 3). Surprisingly, studies of the changes in IR isoform mRNA during metabolic disease, aimed to find common patterns and possible mechanisms, are scarce. The IR mRNA splicing variants were analyzed by RNA template-specific PCR (RS-PCR) in several tissues of a small group of diabetic rhesus monkeys [71]. Here, the authors showed that hyperinsulinemic monkeys had significantly higher expression of IR-A in
In relation to metabolic diseases, it is worth mentioning that complications of myotonic dystrophy—an autosomal genetic disease characterized by muscle loss and weakness caused by the expansion of nucleotides repeat in 3′ untranslated region of different mRNAs—has been found to alter the IR pre-mRNA splicing [93, 94]. One of the mechanisms involves the function of the CUG-BP splicing factor (acting on CUG repeats), which together with MBNL1 and other splicing factors has been shown to be pivotal for IR gene regulation [95]. In both myotonic dystrophy types 1 and 2 (DM1 and DM2), insulin resistance and decreased muscle insulin sensitivity are common. This correlates with an isoform switch from IR-B to IR-A in muscle, without changes in the total IR protein levels, and can be considered the closest model of IR splicing changes in a specific cell type
In summary, in metabolic diseases such as T2DM or obesity, limited work has been conducted in humans and animal models to uncover IR isoform changes and underlying mechanisms during disease. It seems that long-term metabolic alterations such as the ones occurring during T2DM and obesity alter the IR isoform mRNA ratio in some of the studied tissues. It seems that IR-A/IR-B ratio decreases in muscle and increases in liver and adipose tissue during hyperinsulinemic and T2DM states in humans [48, 63, 67, 89, 90, 92]. It is current consensus in the field that a higher expression of IR-A (considered to drive more mitogenic signals rather than metabolic ones) would enable this isoform to compete with IR-B for insulin, thus reducing the action of IR-B in maintaining glucose homeostasis, leading to insulin resistance. This seems to be the case during diabetes mellitus, although there could be other possible metabolic alterations due to changes in alternative splicing of other genes. Alternatively, a change in IR isoforms ratio could be interpreted as a result of changes in tissue architecture and the increase/decrease of certain cell types expressing one or the other isoforms. In fact, besides one exception, the mentioned investigations were conducted measuring IR isoform mRNA in the whole muscle, liver and adipose tissue. Architecturally, all tissues are composed of different cell types, as well as different subpopulations (heterogeneity) within a specific cell type. For example, in liver and fat, zonation has been described, in which differences in transcriptomics shows that even cells of the same kind display different phenotypes and potentially even specific IR isoform ratios [97, 98]. Thus, without experiments focusing on dissecting the mechanism behind a change in IR isoforms at single-cell resolution, it will be difficult to draw conclusion on the mechanism behind this phenomenon during metabolic disease. Future efforts are therefore required to tackle this issue more in depth to provide a common denominator for the IR changes at cell resolution, possibly taking advantage of a cell type that expresses both IR isoforms, in order to detect if changes in splicing occur.
Since the discovery of the alternative splicing of the IR in 1989 by Seino et al. [50], many studies have focused on understanding the tissue expression patterns, binding affinity, crystal structures, differential signaling and alternative routes of internalization and recycling of the IR isoforms. However, what we currently know about the IR isoforms is only a fraction of what we have not discovered yet. The reason for the two isoforms conferring an evolutionary advantage in mammals, and why other vertebrates, such as birds and fish, exist with just IR-A as well as the reasons behind the complex interactions and redundancy of insulin and IGFs systems are extremely interesting and important questions. Uncovering these aspects together with understanding why IR-A is expressed during development, in stem and cancer cells, and why progenitor cells express mainly IR-A switching their expression to IR-B upon differentiation and specialization, would help decipher the complex regulation of IR-mediated signaling upon their ligand binding. Here below, we present key points, which should be addressed in the near future, along with the tools needed in order to achieve these goals.
Amongst the pioneers of the IR isoform research area, Seino and Mosthaf in the ‘90s pinpointed the importance of determining IR isoforms splicing and their signaling at single cell level [31, 50, 99]. Until now, almost all works investigating the change in IR splice isoforms were performed using whole tissues. Thus, a key question is where/if the IR isoforms are present at the single-cell level
It is common, especially in the research field of metabolic disease to talk about “classical or canonical” and “non-classical or non-canonical” insulin target tissues. The first have most commonly been liver, muscle and fat, while recently also pancreatic islets and brain have been considered. However, all cells in the body express IRs and therefore this distinction might be obsolete. The type and amount of the ligands that can bind the IR and the downstream signaling proteins involved in IR-mediated signaling (i.e., IRSs, PI3Ks, MAPKs, AKTs, etc.) are expressed in different amounts in different cell types within a tissue and this heterogeneity increases the combinatorial possibility of signaling downstream of the receptor (reviewed in [103]).
The current consensus is that an increase of IR-A, with its higher affinity for insulin and IGF2, might induce a strong proliferative signal and decrease the metabolic effect of insulin (reviewed in [56, 104]). There is strong evidence that IR-A is increased in cancer, where it exerts a proliferative and survival advantage. However, the fact that IR-A transduces a mitogenic signal in non-cancer and non-stem cells, where both isoforms are present, seems not always to be the case. In pancreatic β-cell, where both IR isoforms are present, the IR-A induces a downstream activation of insulin gene transcription and does not confer proliferative effects [43]. Of note, the pancreatic β-cell is the only primary non-cancer cell, together with kidney podocytes, from which there is evidence of IR isoform-specific signal transduction, and for which downstream pathways have been partially uncovered [43, 46, 47, 105, 106]. Moreover, cells with high prevalence of IR-A such as neurons are clearly not proliferative, showing that alteration of ligands and downstream signaling might be the key factors for the proliferative effect through IR-A.
In cells that express both IR homo-receptors simultaneously, one hypothesis would be that the two isoforms regulate different signaling pathways in the same cell as shown for pancreatic β-cells, due to spatial segregation at the membrane and different downstream binding partners. This could explain the selective insulin resistance (as shown for podocytes [47]) seen in liver or adipose tissue, where only some downstream signals of the insulin signaling pathway are blunted during disease [107, 108]. However, the selective insulin resistance in liver or fat linked to the IR isoforms still depends on the possibility that hepatocytes and adipocytes express IR-A. Moreover, if we hypothesize that of the total IR in hepatocytes or adipocytes only 10% is IR-A, then IR-A homo-receptors should be absent and IR-A would be found forming hetero-receptors with IR-B, unless some mechanism of segregation is present to preserve homo-dimer assembly.
An understudied variable that could potentially alter insulin signaling during metabolic disease is the binding of proinsulin to IR-A and its possible downstream effect. In fact, it is still not clear if this binding results in a signal transduction, or if the IR acts as a “sponge” for proinsulin resulting in a decrease in insulin binding. This aspect could play an important role during T2DM development, where the proinsulin/insulin ratio is increased in plasma [37].
In summary, much work needs to be done to understand basic questions regarding the IR isoform expression and signaling in specific cell types and during disease. However, essential tools to discriminate between the two IR isoforms are lacking and critical to address these important issues and provide breakthroughs in the field.
Up until now, measuring IR isoform mRNA has been useful to investigate the isoforms at tissue level, and more recently at cellular resolution
Pivotal to understanding the dynamics and the regulation of the equilibrium of the IR isoforms (and therefore signaling) in health and disease is to develop tools with the possibility to visualize the amount and localization of the mature isoform receptors. Up to now, attempts to develop an isoform-specific antibody for Western blotting or immunostaining have failed, probably due to the small difference between the two denatured proteins and to the fact that the 12 differential amino acids reside in a poorly accessible area of the receptor. Means to visualize the IR isoform in live cells would allow studying the binding of ligands to the IR isoforms at the cell membrane. Additionally, other small molecules such as aptamers, nucleotides oligomers that could differentially bind to the IR isoforms could conjugate with fluorescent dyes and allow the visualization of endogenous IR receptor monomers or dimers in living cells. Such visualization would allow to track the receptors
Alternatively, the results of overexpression studies can be useful in understanding the possible segregation of the IRs due to different lipid membrane requirements, and possibly signaling [110]. However, a spill over of signaling and changes in IR distribution could take place due to overexpression and the results would need to be confirmed based on the endogenous receptor.
Let us imagine having the available methods to visualize and measure the IR at the protein level as well as the cellular distribution of IR-A/IR-B monomers, dimers and hybrids receptors. With these tools it would be possible to study which signals are transduced by the IR isoforms in a determined cell type and in response to insulin, proinsulin, IGF1 and IGF2. In this scenario, new discoveries could be used to develop targeted treatments for metabolic diseases. For example, we could screen for selective activators and inhibitors of the different IR isoforms by measuring downstream activation of selective pathways in specific healthy or diseased cells.
We have discussed the necessity of being able to understand the specific signaling cascades initiated by the different receptors upon ligand binding. The two IR isoforms could be considered as targets to selectively increase or decrease signaling pathways driven by one of the two receptors in specific cell types. Focusing on diabetes, and provided that signaling pathways downstream of IR-B are the ones modulating glucose metabolism, the generation of selective IR-B activators could be beneficial in comparison to the current insulin sensitizers or insulin analogues, which do not target either isoform specifically. On the contrary, selectively targeting IR-A, using specific antibodies or other therapeutic molecules, could be directed to treat tumor proliferation by blunting its mitogenic signaling pathways and thus hamper cell growth and survival. Newly developed insulin analogues that preferentially bind one or the other IR isoform [111] could be pivotal for improving insulin therapy, but to define this feature we would need to have tools to measure selective downstream signaling in specific cells and tissues to understand the potency and effect of such molecules. Not only peptides could be used to modulate the IR isoform activity in a selective manner, but other small molecules such as aptamers could also prove useful. One promising publication showed that these molecules can be IR isoform-specific and can facilitate or block the signaling selectively, working as allosteric regulators [112].
Another intriguing therapeutic possibility to modulate IR splice isoforms would be to use a selective splice switcher, which has recently been tested (reviewed in [113]). This would also be a better strategy to study the IR isoforms
In this chapter, we aimed to summarize the state of the art research involving the IR isoforms, especially in the area of metabolic disease. We also wanted to draw attention to how important it is to understand the full implications of having two IR isoforms. The majority of the research focused on insulin signaling refers to the IR as one receptor, without considering that there are two structurally and functionally distinct isoforms in play. In our view, future research in this field would benefit from a focus on cell type-specific IR isoform signal transduction pathways, what differences there may be between cells of the same type but different localization in a tissue, and finally, what changes occur during disease. The development of the tools needed to address these questions would pave the way for important breakthroughs in comprehending the ubiquitous, but diverse, IR signaling. Finally, these tools will be essential for the development and testing of new therapeutic strategies to counteract diseases affected by IR signaling dysfunction.
We would like to thank Ingo and Barbara Leibiger for the critical reading of this chapter and their contribution as part of the Per-Olof Berggren lab in the field of IR isoforms in pancreatic islets.
The authors declare no conflict of interest.
All publications on this website are published under the Open Access model, without any subscription, registration, or access fees required from the user or his/her institution. In accordance with the Budapest Open Access Initiative's (BOAI) definition of Open Access, users are allowed to read, download, copy, distribute, print, search, and link to the full text versions of all Chapters. To read more about our Open Access Statement click here.
\n\nFor Editorial Policies for journals please consult individual journal pages.
',metaTitle:"Editorial policies",metaDescription:"Editorial policies",metaKeywords:null,canonicalURL:"/page/editorial-policies",contentRaw:'[{"type":"htmlEditorComponent","content":"All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
\\n\\n\\n\\nWith the purpose of protecting our Authors' copyright and the transparent reuse of Open Access content, IntechOpen has developed an Attribution Policy for works published under Creative Commons licenses.
\\n\\n\\n\\nIntechOpen is committed to disseminating high-quality scientific research in a manner that exemplifies the best practice in scholarly publishing. IntechOpen is an official member of the Committee on Publication Ethics (COPE), which advocates the maintenance of the highest ethical standards for all parties involved in the act of publishing, including Authors, Academic Editors of the book, Peer Reviewers, the publisher and Societies, where applicable.
\\n\\nIn line with publication ethics practices recommended by COPE, ICMJE, and other similar organizations, IntechOpen's contributing Authors, Academic Editors, and Peer Reviewers are required to declare fully all possible conflicts of interest.
\\n\\n\\n\\nIntechOpen's Authorship Policy is based on ICMJE criteria for authorship. In order to be identified as an Author, the following requirements must be met:
\\n\\nAll scientific works are subject to Peer Review prior to publishing. IntechOpen is a member of the Committee on Publication Ethics (COPE) and all participating referees and Academic Editors are expected to review submitted scientific works in line with the COPE Ethical Guidelines for Peer Reviewers where applicable.
\\n\\n\\n\\nThe Internet has changed the dynamics of scholarly communication and publishing which is why we find it necessary to clearly indicate our stance on what we consider to be a published scientific work. A significant number of working papers, early drafts, and similar works in progress are shared openly online between members of the scientific community. It has become common practice for researchers to announce their work on a personal website or a blog in order to gather comments and suggestions from other researchers. Such works and online postings are ‘published’ in the sense that they are made publicly available, but this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\\n\\n\\n\\nTo identify instances of fraud and misconduct during the publishing process, IntechOpen implements a robust policy governing such occurrences. In line with our general commitment to openness, and in order to maintain the highest scientific standards, we are committed to transparency about our editorial policy regarding retractions and corrections.
\\n\\n\\n\\nWhen faced with potential misconduct, IntechOpen accepts its responsibility to maintain the integrity of the academic record. For particularly complex cases, IntechOpen might ask for the assistance of formal industry bodies or seek advice from an appropriate team of advisors.
\\n\\nIntechOpen's advisors are professionals and scholars with broad knowledge and understanding of different aspects of the scientific publishing process: editorial, authorship, and reviewing roles; publication ethics, copyright, and general legal issues; as well as bibliographic and technical standards.
\\n\\nIn order to provide us with unbiased insights, without compromising the privacy of third parties, IntechOpen presents problematic cases to its advisors in an anonymized format.
\\n\\nIntechOpen publishes books in the English language. If you are interested in the translation of Book Chapters, please check IntechOpen's Translation Policy.
\\n\\n\\n\\nIn line with the Principles of Transparency and Best Practice in Scholarly Publishing, you can access a more detailed description of IntechOpen's Advertising Policy.
\\n\\n\\n\\nAt IntechOpen we realize that exceptional circumstances can occur, resulting in a request for a refund. We will honor all justified requests in the specific instances outlined in our Refund Policy.
\\n\\n\\n\\nAll chapters will be published via IntechOpen's 'Online First' service meaning chapters will be published individually, immediately after review and before the entire book is ready for publication, allowing content to be shared, searched and cited straightaway, thereby generating early stage interest and momentum for your research
\\n\\nOnline First Chapters are considered published on the day they are posted and are citable from that date.
\\n\\nChapters will remain listed as Online First until the final versions of the books are published online. Following publication of the full monograph, Chapters will be redirected from the Online First version and will be available only through the final link of the official published page.
\\n\\nYou are invited to download, use, reproduce, make derivative works of, display, distribute and cite the Online First works. You can find "How to Cite and Reference" by following the link at the end of each online book chapter. Please be aware that it is possible that further editing and changes might be made before the final release of the book.
\\n\\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
\\n\\nReaders and Authors can notify us if they find any errors in the works published under Online First. All major errors will be accompanied by a separate correction notice, erratum or corrigendum (Retraction and Correction Policy.)
\\n\\nIntechOpen books are available online by accessing all published content on a chapter level.
\\n\\n\\n\\nIntechOpen publishes different types of publications.
\\n\\n\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
\n\n\n\nWith the purpose of protecting our Authors' copyright and the transparent reuse of Open Access content, IntechOpen has developed an Attribution Policy for works published under Creative Commons licenses.
\n\n\n\nIntechOpen is committed to disseminating high-quality scientific research in a manner that exemplifies the best practice in scholarly publishing. IntechOpen is an official member of the Committee on Publication Ethics (COPE), which advocates the maintenance of the highest ethical standards for all parties involved in the act of publishing, including Authors, Academic Editors of the book, Peer Reviewers, the publisher and Societies, where applicable.
\n\nIn line with publication ethics practices recommended by COPE, ICMJE, and other similar organizations, IntechOpen's contributing Authors, Academic Editors, and Peer Reviewers are required to declare fully all possible conflicts of interest.
\n\n\n\nIntechOpen's Authorship Policy is based on ICMJE criteria for authorship. In order to be identified as an Author, the following requirements must be met:
\n\nAll scientific works are subject to Peer Review prior to publishing. IntechOpen is a member of the Committee on Publication Ethics (COPE) and all participating referees and Academic Editors are expected to review submitted scientific works in line with the COPE Ethical Guidelines for Peer Reviewers where applicable.
\n\n\n\nThe Internet has changed the dynamics of scholarly communication and publishing which is why we find it necessary to clearly indicate our stance on what we consider to be a published scientific work. A significant number of working papers, early drafts, and similar works in progress are shared openly online between members of the scientific community. It has become common practice for researchers to announce their work on a personal website or a blog in order to gather comments and suggestions from other researchers. Such works and online postings are ‘published’ in the sense that they are made publicly available, but this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\n\n\nTo identify instances of fraud and misconduct during the publishing process, IntechOpen implements a robust policy governing such occurrences. In line with our general commitment to openness, and in order to maintain the highest scientific standards, we are committed to transparency about our editorial policy regarding retractions and corrections.
\n\n\n\nWhen faced with potential misconduct, IntechOpen accepts its responsibility to maintain the integrity of the academic record. For particularly complex cases, IntechOpen might ask for the assistance of formal industry bodies or seek advice from an appropriate team of advisors.
\n\nIntechOpen's advisors are professionals and scholars with broad knowledge and understanding of different aspects of the scientific publishing process: editorial, authorship, and reviewing roles; publication ethics, copyright, and general legal issues; as well as bibliographic and technical standards.
\n\nIn order to provide us with unbiased insights, without compromising the privacy of third parties, IntechOpen presents problematic cases to its advisors in an anonymized format.
\n\nIntechOpen publishes books in the English language. If you are interested in the translation of Book Chapters, please check IntechOpen's Translation Policy.
\n\n\n\nIn line with the Principles of Transparency and Best Practice in Scholarly Publishing, you can access a more detailed description of IntechOpen's Advertising Policy.
\n\n\n\nAt IntechOpen we realize that exceptional circumstances can occur, resulting in a request for a refund. We will honor all justified requests in the specific instances outlined in our Refund Policy.
\n\n\n\nAll chapters will be published via IntechOpen's 'Online First' service meaning chapters will be published individually, immediately after review and before the entire book is ready for publication, allowing content to be shared, searched and cited straightaway, thereby generating early stage interest and momentum for your research
\n\nOnline First Chapters are considered published on the day they are posted and are citable from that date.
\n\nChapters will remain listed as Online First until the final versions of the books are published online. Following publication of the full monograph, Chapters will be redirected from the Online First version and will be available only through the final link of the official published page.
\n\nYou are invited to download, use, reproduce, make derivative works of, display, distribute and cite the Online First works. You can find "How to Cite and Reference" by following the link at the end of each online book chapter. Please be aware that it is possible that further editing and changes might be made before the final release of the book.
\n\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
\n\nReaders and Authors can notify us if they find any errors in the works published under Online First. All major errors will be accompanied by a separate correction notice, erratum or corrigendum (Retraction and Correction Policy.)
\n\nIntechOpen books are available online by accessing all published content on a chapter level.
\n\n\n\nIntechOpen publishes different types of publications.
\n\n\n\n\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",src:"EDCMP"},books:[{type:"book",id:"11254",title:"Optical Coherence Tomography",subtitle:null,isOpenForSubmission:!0,hash:"a958c09ceaab1fc44c1dd0a817f48c92",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11254.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11436",title:"Beauty",subtitle:null,isOpenForSubmission:!0,hash:"0e15ba86bab1a64f950318f3ab2584ed",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Pandemics",subtitle:null,isOpenForSubmission:!0,hash:"bc9e4cab86c76f35cd70b39086d9b69e",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11472",title:"21st Century Slavery",subtitle:null,isOpenForSubmission:!0,hash:"b341f3fc3411ced881e43ce007a892b8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11472.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11473",title:"Social Inequality",subtitle:null,isOpenForSubmission:!0,hash:"20307129f7fb39aa443d5449acb6a784",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11546",title:"Smart and Sustainable Transportation",subtitle:null,isOpenForSubmission:!0,hash:"e8ea27a1ff85cde00efcb6f6968c20f8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11546.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11554",title:"Information Systems Management",subtitle:null,isOpenForSubmission:!0,hash:"3134452ff2fdec020663f241c7a9a748",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11554.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11605",title:"Bamboo",subtitle:null,isOpenForSubmission:!0,hash:"378d957561b27c86b750a9c7841a5d18",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11605.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11616",title:"Foraging",subtitle:null,isOpenForSubmission:!0,hash:"955b60bb658c8d1a09dd4efc9bf6674b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11616.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11645",title:"Neural Tube Defects",subtitle:null,isOpenForSubmission:!0,hash:"08d6ba70d97767769a97cfeeb52dac78",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11645.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11649",title:"Carnivora",subtitle:null,isOpenForSubmission:!0,hash:"cfe96fa2ecf64b22057163f9896dc476",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11649.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:36},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:15},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:14},{group:"topic",caption:"Engineering",value:11,count:31},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:7},{group:"topic",caption:"Materials Science",value:14,count:11},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:96},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:7},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:31},{group:"topic",caption:"Technology",value:24,count:1}],offset:12,limit:12,total:321},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3385,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1875,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3842,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3008,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1109,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1010,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3918,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",publishedDate:"May 11th 2022",numberOfDownloads:1654,editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7686,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3444,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10522",title:"Coding Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"6357e1dd7d38adeb519ca7a10dc9e5a0",slug:"coding-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Sudhakar Radhakrishnan and Sudev Naduvath",coverURL:"https://cdn.intechopen.com/books/images_new/10522.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"26327",title:"Dr.",name:"Sudhakar",middleName:null,surname:"Radhakrishnan",slug:"sudhakar-radhakrishnan",fullName:"Sudhakar Radhakrishnan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10821",title:"Automation and Control",subtitle:"Theories and Applications",isOpenForSubmission:!1,hash:"18463c2291ba306c4dcbabd988227eea",slug:"automation-and-control-theories-and-applications",bookSignature:"Elmer P. Dadios",coverURL:"https://cdn.intechopen.com/books/images_new/10821.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11348",title:"Mutagenesis and Mitochondrial-Associated Pathologies",subtitle:null,isOpenForSubmission:!1,hash:"001972b3c5b49367314b13025a449232",slug:"mutagenesis-and-mitochondrial-associated-pathologies",bookSignature:"Michael Fasullo and Angel Catala",coverURL:"https://cdn.intechopen.com/books/images_new/11348.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"258231",title:"Dr.",name:"Michael",middleName:"Thomas",surname:"Fasullo",slug:"michael-fasullo",fullName:"Michael Fasullo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11123",title:"Epoxy-Based Composites",subtitle:null,isOpenForSubmission:!1,hash:"c1c5447cf3b9d6c7688276ac30e80de6",slug:"epoxy-based-composites",bookSignature:"Samson Jerold Samuel Chelladurai, Ramesh Arthanari and M.R.Meera",coverURL:"https://cdn.intechopen.com/books/images_new/11123.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"247421",title:"Dr.",name:"Samson Jerold Samuel",middleName:null,surname:"Chelladurai",slug:"samson-jerold-samuel-chelladurai",fullName:"Samson Jerold Samuel Chelladurai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10632",title:"Theory and Practice of Tunnel Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7ba17749f9d0b6a62d584a3c320a1f49",slug:"theory-and-practice-of-tunnel-engineering",bookSignature:"Hasan Tosun",coverURL:"https://cdn.intechopen.com/books/images_new/10632.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"79083",title:"Prof.",name:"Hasan",middleName:null,surname:"Tosun",slug:"hasan-tosun",fullName:"Hasan Tosun"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10906",title:"Fungal Reproduction and Growth",subtitle:null,isOpenForSubmission:!1,hash:"f84de0280d54f3b52e3e4585cff24ac1",slug:"fungal-reproduction-and-growth",bookSignature:"Sadia Sultan and Gurmeet Kaur Surindar Singh",coverURL:"https://cdn.intechopen.com/books/images_new/10906.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"176737",title:"Dr.",name:"Sadia",middleName:null,surname:"Sultan",slug:"sadia-sultan",fullName:"Sadia Sultan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10914",title:"Effective Elimination of Structural Racism",subtitle:null,isOpenForSubmission:!1,hash:"f6a2562646c0fd664aca8335bc3b3e69",slug:"effective-elimination-of-structural-racism",bookSignature:"Erick Guerrero",coverURL:"https://cdn.intechopen.com/books/images_new/10914.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"294761",title:"Dr.",name:"Erick",middleName:null,surname:"Guerrero",slug:"erick-guerrero",fullName:"Erick Guerrero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,isOpenForSubmission:!1,hash:"2d66af42fb17d0a6556bb9ef28e273c7",slug:"animal-reproduction",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10940",title:"Plant Hormones",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"5aae8a345f8047ed528914ff3491f643",slug:"plant-hormones-recent-advances-new-perspectives-and-applications",bookSignature:"Christophe Hano",coverURL:"https://cdn.intechopen.com/books/images_new/10940.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10207",title:"Sexual Abuse",subtitle:"An Interdisciplinary Approach",isOpenForSubmission:!1,hash:"e1ec1d5a7093490df314d7887e0b3809",slug:"sexual-abuse-an-interdisciplinary-approach",bookSignature:"Ersi Kalfoğlu and Sotirios Kalfoglou",coverURL:"https://cdn.intechopen.com/books/images_new/10207.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"68678",title:"Dr.",name:"Ersi",middleName:null,surname:"Kalfoglou",slug:"ersi-kalfoglou",fullName:"Ersi Kalfoglou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"18",title:"Neuroscience",slug:"life-sciences-neuroscience",parent:{id:"2",title:"Life Sciences",slug:"life-sciences"},numberOfBooks:65,numberOfSeries:0,numberOfAuthorsAndEditors:1649,numberOfWosCitations:1070,numberOfCrossrefCitations:728,numberOfDimensionsCitations:1700,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"18",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10922",title:"Music in Health and Diseases",subtitle:null,isOpenForSubmission:!1,hash:"6a079df045b086b404399c5ed4ac049a",slug:"music-in-health-and-diseases",bookSignature:"Amit Agrawal, Roshan Sutar and Anvesh Jallapally",coverURL:"https://cdn.intechopen.com/books/images_new/10922.jpg",editedByType:"Edited by",editors:[{id:"100142",title:"Prof.",name:"Amit",middleName:null,surname:"Agrawal",slug:"amit-agrawal",fullName:"Amit Agrawal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10554",title:"Proprioception",subtitle:null,isOpenForSubmission:!1,hash:"e104e615fbd94caa987df3a8d8b3fb8b",slug:"proprioception",bookSignature:"José A. Vega and Juan Cobo",coverURL:"https://cdn.intechopen.com/books/images_new/10554.jpg",editedByType:"Edited by",editors:[{id:"59892",title:"Prof.",name:"José A.",middleName:null,surname:"Vega",slug:"jose-a.-vega",fullName:"José A. Vega"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9853",title:"Connectivity and Functional Specialization in the Brain",subtitle:null,isOpenForSubmission:!1,hash:"79f611488f3217579b5c84978f870863",slug:"connectivity-and-functional-specialization-in-the-brain",bookSignature:"Thomas Heinbockel and Yongxia Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/9853.jpg",editedByType:"Edited by",editors:[{id:"70569",title:"Dr.",name:"Thomas",middleName:null,surname:"Heinbockel",slug:"thomas-heinbockel",fullName:"Thomas Heinbockel"}],equalEditorOne:{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",biography:"Yongxia Zhou obtained a Ph.D. in Biomedical Imaging from the University of Southern California. Her research interest is radiology and neuroscience technology and application. She had been trained as an imaging scientist at several prestigious institutes including Columbia University, the University of Pennsylvania, and the National Institutes of Health (NIH). Her research focuses on multi-modal neuroimaging integration such as MRI/PET and EEG/MEG instrumentation to make the best use of multiple modalities for better interpretation of underlying disease mechanisms. She is the author and editor of more than twelve books for well-known publishers including IntechOpen and Nova Science. She has published more than 100 papers and abstracts in many reputed international journals and conferences and served as reviewer and editor for several academic associations.",institutionString:"University of Southern California",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9629",title:"Electroencephalography",subtitle:"From Basic Research to Clinical Applications",isOpenForSubmission:!1,hash:"8147834b6c6deeeec40f407c71ad60b4",slug:"electroencephalography-from-basic-research-to-clinical-applications",bookSignature:"Hideki Nakano",coverURL:"https://cdn.intechopen.com/books/images_new/9629.jpg",editedByType:"Edited by",editors:[{id:"196461",title:"Prof.",name:"Hideki",middleName:null,surname:"Nakano",slug:"hideki-nakano",fullName:"Hideki Nakano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10475",title:"Smart Biofeedback",subtitle:"Perspectives and Applications",isOpenForSubmission:!1,hash:"8d2bd9997707c905959eaa41e55ba8f1",slug:"smart-biofeedback-perspectives-and-applications",bookSignature:"Edward Da-Yin Liao",coverURL:"https://cdn.intechopen.com/books/images_new/10475.jpg",editedByType:"Edited by",editors:[{id:"3875",title:"Dr.",name:"Edward Da-Yin",middleName:null,surname:"Liao",slug:"edward-da-yin-liao",fullName:"Edward Da-Yin Liao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8059",title:"Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice",subtitle:null,isOpenForSubmission:!1,hash:"8cc2c649900edf37ff3374fdc96a1586",slug:"neurostimulation-and-neuromodulation-in-contemporary-therapeutic-practice",bookSignature:"Denis Larrivee and Seyed Mansoor Rayegani",coverURL:"https://cdn.intechopen.com/books/images_new/8059.jpg",editedByType:"Edited by",editors:[{id:"206412",title:"Prof.",name:"Denis",middleName:null,surname:"Larrivee",slug:"denis-larrivee",fullName:"Denis Larrivee"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8851",title:"Advances in Neural Signal Processing",subtitle:null,isOpenForSubmission:!1,hash:"a44ac118b233b29a3d5b57d61680ec38",slug:"advances-in-neural-signal-processing",bookSignature:"Ramana Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/8851.jpg",editedByType:"Edited by",editors:[{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8751",title:"Somatosensory and Motor Research",subtitle:null,isOpenForSubmission:!1,hash:"86191c18f06e524e0f97a5534fdb2b4c",slug:"somatosensory-and-motor-research",bookSignature:"Toshiaki Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/8751.jpg",editedByType:"Edited by",editors:[{id:"70872",title:"Prof.",name:"Toshiaki",middleName:null,surname:"Suzuki",slug:"toshiaki-suzuki",fullName:"Toshiaki Suzuki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9347",title:"Neuroimaging",subtitle:"Neurobiology, Multimodal and Network Applications",isOpenForSubmission:!1,hash:"a3479e76c6ac538aac76409c9efb7e41",slug:"neuroimaging-neurobiology-multimodal-and-network-applications",bookSignature:"Yongxia Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/9347.jpg",editedByType:"Edited by",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8938",title:"Inhibitory Control Training",subtitle:"A Multidisciplinary Approach",isOpenForSubmission:!1,hash:"bd82354f3bba4af5421337cd42052f86",slug:"inhibitory-control-training-a-multidisciplinary-approach",bookSignature:"Sara Palermo and Massimo Bartoli",coverURL:"https://cdn.intechopen.com/books/images_new/8938.jpg",editedByType:"Edited by",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6998",title:"Synucleins",subtitle:"Biochemistry and Role in Diseases",isOpenForSubmission:!1,hash:"2b4b802fec508928ce8ab9deebd1375f",slug:"synucleins-biochemistry-and-role-in-diseases",bookSignature:"Andrei Surguchov",coverURL:"https://cdn.intechopen.com/books/images_new/6998.jpg",editedByType:"Edited by",editors:[{id:"266540",title:"Dr.",name:"Andrei",middleName:null,surname:"Surguchov",slug:"andrei-surguchov",fullName:"Andrei Surguchov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:65,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"46296",doi:"10.5772/57398",title:"Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity",slug:"physiological-role-of-amyloid-beta-in-neural-cells-the-cellular-trophic-activity",totalDownloads:5886,totalCrossrefCites:18,totalDimensionsCites:31,abstract:null,book:{id:"3846",slug:"neurochemistry",title:"Neurochemistry",fullTitle:"Neurochemistry"},signatures:"M. del C. Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. Luna-Muñoz and M.A.\nMeraz-Ríos",authors:[{id:"42225",title:"Dr.",name:"Jose",middleName:null,surname:"Luna-Muñoz",slug:"jose-luna-munoz",fullName:"Jose Luna-Muñoz"},{id:"114746",title:"Dr.",name:"Marco",middleName:null,surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"169616",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Cardenas-Aguayo",slug:"maria-del-carmen-cardenas-aguayo",fullName:"Maria del Carmen Cardenas-Aguayo"},{id:"169857",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Silva-Lucero",slug:"maria-del-carmen-silva-lucero",fullName:"Maria del Carmen Silva-Lucero"},{id:"169858",title:"Dr.",name:"Maribel",middleName:null,surname:"Cortes-Ortiz",slug:"maribel-cortes-ortiz",fullName:"Maribel Cortes-Ortiz"},{id:"169859",title:"Dr.",name:"Berenice",middleName:null,surname:"Jimenez-Ramos",slug:"berenice-jimenez-ramos",fullName:"Berenice Jimenez-Ramos"},{id:"169860",title:"Dr.",name:"Laura",middleName:null,surname:"Gomez-Virgilio",slug:"laura-gomez-virgilio",fullName:"Laura Gomez-Virgilio"},{id:"169861",title:"Dr.",name:"Gerardo",middleName:null,surname:"Ramirez-Rodriguez",slug:"gerardo-ramirez-rodriguez",fullName:"Gerardo Ramirez-Rodriguez"},{id:"169862",title:"Dr.",name:"Eduardo",middleName:null,surname:"Vera-Arroyo",slug:"eduardo-vera-arroyo",fullName:"Eduardo Vera-Arroyo"},{id:"169863",title:"Dr.",name:"Rosana Sofia",middleName:null,surname:"Fiorentino-Perez",slug:"rosana-sofia-fiorentino-perez",fullName:"Rosana Sofia Fiorentino-Perez"},{id:"169864",title:"Dr.",name:"Ubaldo",middleName:null,surname:"Garcia",slug:"ubaldo-garcia",fullName:"Ubaldo Garcia"}]},{id:"58070",doi:"10.5772/intechopen.72427",title:"MRI Medical Image Denoising by Fundamental Filters",slug:"mri-medical-image-denoising-by-fundamental-filters",totalDownloads:2564,totalCrossrefCites:17,totalDimensionsCites:30,abstract:"Nowadays Medical imaging technique Magnetic Resonance Imaging (MRI) plays an important role in medical setting to form high standard images contained in the human brain. MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:289,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:0,paginationItems:[]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{},onlineFirstChapters:{paginationCount:18,paginationItems:[{id:"81778",title:"Influence of Mechanical Properties of Biomaterials on the Reconstruction of Biomedical Parts via Additive Manufacturing Techniques: An Overview",doi:"10.5772/intechopen.104465",signatures:"Babatunde Olamide Omiyale, Akeem Abiodun Rasheed, Robinson Omoboyode Akinnusi and Temitope Olumide Olugbade",slug:"influence-of-mechanical-properties-of-biomaterials-on-the-reconstruction-of-biomedical-parts-via-add",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}},{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81412",title:"Mathematical Morphology and the Heart Signals",doi:"10.5772/intechopen.104113",signatures:"Taouli Sidi Ahmed",slug:"mathematical-morphology-and-the-heart-signals",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81360",title:"Deep Learning Algorithms for Efficient Analysis of ECG Signals to Detect Heart Disorders",doi:"10.5772/intechopen.103075",signatures:"Sumagna Dey, Rohan Pal and Saptarshi Biswas",slug:"deep-learning-algorithms-for-efficient-analysis-of-ecg-signals-to-detect-heart-disorders",totalDownloads:32,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81294",title:"Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine",doi:"10.5772/intechopen.104044",signatures:"Jing Gong, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang and Haiwei Xu",slug:"applications-of-neural-organoids-in-neurodevelopment-and-regenerative-medicine",totalDownloads:26,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81318",title:"Retinal Organoids over the Decade",doi:"10.5772/intechopen.104258",signatures:"Jing Yuan and Zi-Bing Jin",slug:"retinal-organoids-over-the-decade",totalDownloads:42,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81068",title:"Characteristic Profiles of Heart Rate Variability in Depression and Anxiety",doi:"10.5772/intechopen.104205",signatures:"Toshikazu Shinba",slug:"characteristic-profiles-of-heart-rate-variability-in-depression-and-anxiety",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},subseriesFiltersForOFChapters:[{caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1,group:"subseries"},{caption:"Bioinformatics and Medical Informatics",value:7,count:13,group:"subseries"}],publishedBooks:{paginationCount:0,paginationItems:[]},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:25,paginationItems:[{id:"429683",title:"Dr.",name:"Bilal",middleName:null,surname:"Khalid",slug:"bilal-khalid",fullName:"Bilal Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/429683/images/system/429683.png",biography:"Dr. Bilal Khalid received a Ph.D. in Industrial Business Administration from KMITL Business School, Bangkok, in 2021, and a master’s in International Business Management from Stamford International University, Bangkok, in 2017. Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",country:{name:"Canada"}}},{id:"189147",title:"Dr.",name:"Hailan",middleName:null,surname:"Salamun",slug:"hailan-salamun",fullName:"Hailan Salamun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189147/images/19274_n.jpeg",biography:"Hailan Salamun, (Dr.) was born in Selangor, Malaysia and graduated from Tunku Ampuan Jamaah Religious High School at Shah Alam. Obtained a degree from the International Islamic University (UIA), Gombak in the field of Islamic Revealed Knowledge and Heritage. Next, I furthered my studies to the professional level to obtain a Diploma in Education at UIA. After serving for several years in school, I furthered my studies to the Master of Dakwah and Leadership at Universiti Kebangsaan Malaysia (UKM), Bangi. I graduated with a Doctor of Philosophy in Principalship Leadership from the University of Malaya (UM) in 2010. I am currently a senior lecturer in the Department of Nationalism and Civilization, Center for Basic and Continuing Education, Universiti Malaysia Terengganu. Prior to that, I had served in several educational institutions such as schools, the Institute of Teacher Education (IPG), and also the University of Malaya. I am also actively involved in paper presentation, writing and publishing. My research interests are focused on leadership, education, society and Islamic civilization. This area of research requires a detailed understanding of Islamic studies and research studies in leadership. Another research interest that I have explored recently is the politics of the Malay community and also the leadership of the mosque.",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"442081",title:"Dr.",name:"Audrey",middleName:null,surname:"Addy",slug:"audrey-addy",fullName:"Audrey Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kwame Nkrumah University of Science and Technology",country:{name:"Ghana"}}},{id:"437993",title:"Mr.",name:"Job",middleName:null,surname:"Jackson",slug:"job-jackson",fullName:"Job Jackson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"428495",title:"Prof.",name:"Asyraf",middleName:null,surname:"Ab Rahman",slug:"asyraf-ab-rahman",fullName:"Asyraf Ab Rahman",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"429650",title:"Dr.",name:"Jacqueline",middleName:null,surname:"Kareem",slug:"jacqueline-kareem",fullName:"Jacqueline Kareem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Christ University",country:{name:"India"}}},{id:"421041",title:"Dr.",name:"Sunil",middleName:null,surname:"Kumar Ramdas",slug:"sunil-kumar-ramdas",fullName:"Sunil Kumar Ramdas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"421833",title:"Mr.",name:"Eugene",middleName:null,surname:"Owusu-Acheampong",slug:"eugene-owusu-acheampong",fullName:"Eugene Owusu-Acheampong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"239876",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Mourão",slug:"luciana-mourao",fullName:"Luciana Mourão",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Salgado de Oliveira",country:{name:"Brazil"}}},{id:"421735",title:"Dr.",name:"elizabeth",middleName:null,surname:"addy",slug:"elizabeth-addy",fullName:"elizabeth addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"442083",title:"Dr.",name:"James",middleName:null,surname:"Addy",slug:"james-addy",fullName:"James Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437991",title:"Prof.",name:"Muhammad",middleName:null,surname:"Hoque",slug:"muhammad-hoque",fullName:"Muhammad Hoque",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421006",title:"Dr.",name:"Anna",middleName:null,surname:"Uster",slug:"anna-uster",fullName:"Anna Uster",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470243",title:"Dr.",name:"Md Samim",middleName:null,surname:"Al Azad",slug:"md-samim-al-azad",fullName:"Md Samim Al Azad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470244",title:"Dr.",name:"Slimane",middleName:null,surname:"Ed-dafali",slug:"slimane-ed-dafali",fullName:"Slimane Ed-dafali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421011",title:"Dr.",name:"Afatakpa",middleName:null,surname:"Fortune",slug:"afatakpa-fortune",fullName:"Afatakpa Fortune",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446057",title:"Mr.",name:"Okedare",middleName:null,surname:"David Olubukunmi",slug:"okedare-david-olubukunmi",fullName:"Okedare David Olubukunmi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421778",title:"Dr.",name:"Fatimah",middleName:"Saeed",surname:"AlAhmari",slug:"fatimah-alahmari",fullName:"Fatimah AlAhmari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421024",title:"Prof.",name:"Harold Andrew",middleName:null,surname:"Patrick",slug:"harold-andrew-patrick",fullName:"Harold Andrew Patrick",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421065",title:"Ms.",name:"Euzália",middleName:null,surname:"do Rosário Botelho Tomé",slug:"euzalia-do-rosario-botelho-tome",fullName:"Euzália do Rosário Botelho Tomé",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421053",title:"Associate Prof.",name:"Ken",middleName:null,surname:"Kalala Ndalamba",slug:"ken-kalala-ndalamba",fullName:"Ken Kalala Ndalamba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421826",title:"Dr.",name:"Inusah",middleName:null,surname:"Salifu",slug:"inusah-salifu",fullName:"Inusah Salifu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"420823",title:"Prof.",name:"Gardênia da Silva",middleName:null,surname:"Abbad",slug:"gardenia-da-silva-abbad",fullName:"Gardênia da Silva Abbad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437613",title:"MSc.",name:"Juliana",middleName:null,surname:"Legentil",slug:"juliana-legentil",fullName:"Juliana Legentil",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"23",type:"subseries",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11419,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",slug:"asim-bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",slug:"joao-luis-garcia-rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:0,paginationItems:[]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/193837",hash:"",query:{},params:{id:"193837"},fullPath:"/profiles/193837",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()