Gheorghita Isvoranu

Institutul National Victor Babes Romania

Gheorghita Isvoranu, PhD, is currently a research scientist at “Victor Babeș” National Institute of Pathology, Bucharest, Romania. In 2012, she got her PhD degree in Biology, at the University of Bucharest. She is author and/or coauthor of over 20 scientific papers and conference abstracts and also a book chapter. Her major areas of scientific interest include immunology, ancer therapy, and regenerative medicine. Gheorghita Isvoranu is also a member of the Romanian Society of Immunology and Romanian Association for Laboratory Animal Science.

1books edited

1chapters authored

Latest work with IntechOpen by Gheorghita Isvoranu

This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

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Lymphocyte Updates

Edited by Gheorghita Isvoranu

Chapters authored

The Memory Activation of NK Cells: New Methods in Cancer Immunotherapy

By Gheorghita Isvoranu

Cancer remains a main cause of mortality, despite the research efforts to unravel molecular mechanisms and for developing personalized targeted therapies with acceptable side effects. In cancer, both players, the aggressor (tumor cells) and the endogenous defenders (immune cells), are key therapeutic targets. Immunotherapy is nowadays considered the fourth therapeutical approach in cancer, complementing and sometimes replacing surgery and chemo‐ and radiotherapy. Natural killer (NK) cells, generally considered part of the innate immune system, play a critical role in defense against pathogens and tumors. Immunological memory is a hallmark of the adaptive immune system. However, NK cells have been shown to mediate Ag‐specific recall responses and acquire immunological memory in a manner similar to that of T and B cells. This chapter summarizes evidence for NK cell immunotherapy, evidence and characteristics of NK cell memory and mechanisms involved in the generation and survival of these cells. There is no doubt that NK cells have major role in cancer treatments and viral infections, and in the future, NK cell immunotherapy from “a new hope” may become “a reality” for malignant diseases.

Part of the book: Immunotherapy

Gheorghita Isvoranu

Latest work with IntechOpen by Gheorghita Isvoranu

Lymphocyte Updates

Chapters authored

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