\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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Dunn",authors:[{id:"18367",title:"Dr.",name:"Robert",middleName:null,surname:"Dunn",fullName:"Robert Dunn",slug:"robert-dunn"}]},{id:"15789",title:"Seed Storage Proteins; Strategies for Developing Crops Promoting Human Health",slug:"seed-storage-proteins-strategies-for-developing-crops-promoting-human-health",signatures:"Nobuyuki Maruyama, Takayasu Motoyama, Masaaki Yoshikawa, Fumio Takaiwa and Shigeru Utsumi",authors:[{id:"18385",title:"Dr.",name:"Nobuyuki",middleName:null,surname:"Maruyama",fullName:"Nobuyuki Maruyama",slug:"nobuyuki-maruyama"}]},{id:"15790",title:"Soybean Seeds Produced in Out Season in West of Paraná State – Brazil",slug:"soybean-seeds-produced-in-out-season-in-west-of-paran-state-brazil",signatures:"Marizangela Rizzatti Ávila, Alessandro de Lucca e Braccini, Leandro Paiola Albrecht and Carlos Alberto Scapim",authors:[{id:"21047",title:"Dr.",name:"Marizangela",middleName:null,surname:"Ávila",fullName:"Marizangela Ávila",slug:"marizangela-avila"},{id:"21048",title:"Dr.",name:"Alessandro",middleName:null,surname:"Lucca Braccini",fullName:"Alessandro Lucca Braccini",slug:"alessandro-lucca-braccini"},{id:"21049",title:"Dr.",name:"Carlos",middleName:null,surname:"Scapim",fullName:"Carlos Scapim",slug:"carlos-scapim"},{id:"23525",title:"Dr.",name:"Leandro",middleName:null,surname:"Albrecht",fullName:"Leandro Albrecht",slug:"leandro-albrecht"}]},{id:"15829",title:"The Alternatives to Soybeans for Animal Feed in the Tropics",slug:"the-alternatives-to-soybeans-for-animal-feed-in-the-tropics",signatures:"Archimède H, Régnier C, Marie-Magdeleine Chevry C, Gourdine JL, Rodriguez L and Gonzalez E",authors:[{id:"17514",title:"Dr.",name:"Harry",middleName:null,surname:"Archimède",fullName:"Harry Archimède",slug:"harry-archimede"}]},{id:"15791",title:"Application of Nondestructive Measurement to Improve Soybean Quality by Near Infrared Reflectance Spectroscopy",slug:"application-of-nondestructive-measurement-to-improve-soybean-quality-by-near-infrared-reflectance-sp",signatures:"Jeong-Dong Lee, J. Grover Shannon and Myoung-Gun Choung",authors:[{id:"21386",title:"Dr.",name:"Myoung-Gun",middleName:null,surname:"Choung",fullName:"Myoung-Gun Choung",slug:"myoung-gun-choung"},{id:"22176",title:"Prof.",name:"Jeong-Dong",middleName:null,surname:"Lee",fullName:"Jeong-Dong Lee",slug:"jeong-dong-lee"},{id:"22177",title:"Prof",name:"J. Grover",middleName:null,surname:"Shannon",fullName:"J. Grover Shannon",slug:"j.-grover-shannon"}]},{id:"15792",title:"Solid State Fermentation of Soybean Hulls for Cellulolytic Enzymes Production",slug:"solid-state-fermentation-of-soybean-hulls-for-cellulolytic-enzymes-production",signatures:"Khushal Brijwani and Praveen V. Vadlani",authors:[{id:"17592",title:"Dr.",name:"Praveen V",middleName:null,surname:"Vadlani",fullName:"Praveen V Vadlani",slug:"praveen-v-vadlani"},{id:"21150",title:"Mr",name:"Khushal",middleName:null,surname:"Brijwani",fullName:"Khushal Brijwani",slug:"khushal-brijwani"}]},{id:"15830",title:"Immunoquantitative Measurement of Soybean Aeroallergen Emissions",slug:"immunoquantitative-measurement-of-soybean-aeroallergen-emissions",signatures:"María-Jesús Cruz and Susana Gómez-Ollé",authors:[{id:"17507",title:"Dr.",name:"Maria-Jesus",middleName:null,surname:"Cruz",fullName:"Maria-Jesus Cruz",slug:"maria-jesus-cruz"},{id:"21495",title:"Dr.",name:"Susana",middleName:null,surname:"Gómez-Ollés",fullName:"Susana Gómez-Ollés",slug:"susana-gomez-olles"}]},{id:"15793",title:"Recovery of Phytosterols from Waste Residue of Soybean Oil Deodorizer Distillate",slug:"recovery-of-phytosterols-from-waste-residue-of-soybean-oil-deodorizer-distillate",signatures:"Feng Yan, Haojun Yang, Daogeng Wu, Ming Huo and Jianxin Li",authors:[{id:"17113",title:"Prof.",name:"Jianxin",middleName:null,surname:"Li",fullName:"Jianxin Li",slug:"jianxin-li"},{id:"18646",title:"Prof",name:"Feng",middleName:null,surname:"Yan",fullName:"Feng Yan",slug:"feng-yan"},{id:"18647",title:"Ms",name:"Haojun",middleName:null,surname:"Yang",fullName:"Haojun Yang",slug:"haojun-yang"},{id:"18648",title:"Mr",name:"Daogeng",middleName:null,surname:"Wu",fullName:"Daogeng Wu",slug:"daogeng-wu"},{id:"18649",title:"Ms",name:"Ming",middleName:null,surname:"Huo",fullName:"Ming Huo",slug:"ming-huo"}]},{id:"15794",title:"Soybean-based Surfactants and Their Applications",slug:"soybean-based-surfactants-and-their-applications",signatures:"Qingyi Xu, Mitsutoshi Nakajima, Zengshe Liu and Takeo Shiina",authors:[{id:"18905",title:"Dr.",name:"Qingyi",middleName:null,surname:"Xu",fullName:"Qingyi Xu",slug:"qingyi-xu"},{id:"22088",title:"Dr.",name:"Mitsutoshi",middleName:null,surname:"Nakajima",fullName:"Mitsutoshi Nakajima",slug:"mitsutoshi-nakajima"},{id:"22089",title:"Dr.",name:"Zengshe",middleName:null,surname:"Liu",fullName:"Zengshe Liu",slug:"zengshe-liu"},{id:"22090",title:"Dr.",name:"Takeo",middleName:null,surname:"Shiina",fullName:"Takeo Shiina",slug:"takeo-shiina"}]},{id:"15795",title:"Polymerization of Soybean Oil with Superacids",slug:"polymerization-of-soybean-oil-with-superacids",signatures:"Ionescu Mihail and Petrović S. Zoran",authors:[null]},{id:"15796",title:"Sourdough and Bread Properties as Affected by Soybean Protein Addition",slug:"sourdough-and-bread-properties-as-affected-by-soybean-protein-addition",signatures:"Josué Peñaloza- Espinosa, Gloria J. De La Rosa-Angulo, Rosalva Mora-Escobedo, Jorge Chanona-Pérez, Reynold Farrera-Rebollo and Georgina Calderón-Domínguez",authors:[{id:"19018",title:"Dr.",name:"Rosalva",middleName:null,surname:"Mora Escobedo",fullName:"Rosalva Mora Escobedo",slug:"rosalva-mora-escobedo"},{id:"21263",title:"Dr.",name:"Georgina",middleName:null,surname:"Calderón-Domínguez",fullName:"Georgina Calderón-Domínguez",slug:"georgina-calderon-dominguez"},{id:"22034",title:"Ing",name:"Josue",middleName:null,surname:"Peñaloza-Espinoza",fullName:"Josue Peñaloza-Espinoza",slug:"josue-penaloza-espinoza"},{id:"22035",title:"Dr.",name:"Reynold",middleName:null,surname:"Farrera-Rebollo",fullName:"Reynold Farrera-Rebollo",slug:"reynold-farrera-rebollo"},{id:"22694",title:"Ing",name:"Gloria J.",middleName:null,surname:"De la Rosa-Angulo",fullName:"Gloria J. De la Rosa-Angulo",slug:"gloria-j.-de-la-rosa-angulo"},{id:"22695",title:"Dr.",name:"Jorge",middleName:null,surname:"Chanona-Pérez",fullName:"Jorge Chanona-Pérez",slug:"jorge-chanona-perez"}]}]}]},onlineFirst:{chapter:{type:"chapter",id:"63476",title:"Orthodontics in Relation with Alveolar Bone Grafting in CLP Patients",doi:"10.5772/intechopen.80853",slug:"orthodontics-in-relation-with-alveolar-bone-grafting-in-clp-patients",body:'\nCleft lip and palate (CLP) are among the most common of all congenital facial deformities which affect approximately 1 in every 600 newborn babies worldwide [1]. Congenital CL/P can arise in isolation or together with other syndromes. Alveolar cleft (osseous defect in the alveolus of upper jaw) affects approximately 75% of cleft lip and palate patients [2, 3].
\nThe rehabilitation of individuals with CL/P requires interdisciplinary care by centralization of treatment [1, 4].
\nAs the facial cleft affects the whole stomatognathic system, orthodontics is a core element of the overall treatment process. The orthodontist should aim to provide a dentition that functions well and is capable of lifetime maintenance by routine oral hygiene and dental care. However, the underlying skeletal deformity that reflects intrinsic variation and the consequences of surgery severely restricts occlusal change [5].
\nThere are two major factors which effect orthodontic treatment in patients with CLP:
Facial growth disruption
It is well known that facial growth in patient with CP is disturbed. Besides the intrinsic defect, surgery itself contributes to further disruption [3, 6]. A significant feature of facial growth in repaired CP patients is that the maxilla fails to grow at the same rate as the mandible during the adolescent growth spurt. Progressive midfacial retrusion is usually seen by the mid- to late teens. The results of the facial growth studies revealed the general characteristics of the individuals with UCLP: a short retrusive maxilla and vertical elongation of the anterior face, a retrusive mandible, and a reduction in posterior face height [6, 7, 8, 9].
Alveolar bone deficiency
Lack of the alveolar bone may give rise to a variety of problems, including oronasal fistula, fluid reflux, speech pathology, impaired tooth eruption, lack of bone support for the anterior teeth, dental crowding, periodontal recession and eventual loss of teeth, and maxillary and facial asymmetry. Alveolar defect also limits orthodontic treatment and/or prosthodontic rehabilitation [10, 11, 12].
\nThus, orthodontic treatment for children with cleft should aim to achieve an optimal occlusion and dentofacial esthetics within the constraints imposed by the underlying skeletal pattern [5].
\nThe integration of orthodontics into the overall treatment of CLP starts any point between birth and end of the teens and highly related to surgical procedures, including lip repair, alveolar bone grafting, distraction, and orthognathic surgery [5].
\nThis chapter reviews current orthodontic approaches in relation with alveolar bone grafting (ABG) in nonsyndromic cleft patients.
\nAlveolar bony defect is the main limiting factor for orthodontic treatment. Elimination of the bony defect is provided by alveolar bone grafting (ABG). Since the introduction of secondary alveolar bone grafting (SABG) in 1972, this technique has become an essential step in the overall management of patients with cleft lip and palate (CLP). Providing bone tissue for cleft has following benefits: [10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21]
To permit eruption of the permanent canine in the cleft site into sound bone.
To provide bony support for teeth on either side of the cleft site.
To permit orthodontic tooth movement.
To obviate or minimize the need for prosthetic replacement of teeth in the cleft site.
To permit placement of osseointegrated implants into the cleft area when indicated.
To stabilize maxillary dental arch.
To facilitate fistula closure.
To improve the contour of the alar base.
The long-term success of the alveolar graft is crucial for providing and lifetime maintaining optimal occlusion and dentofacial esthetics in patients with CLP.
\nPostgraft stimulation of maturation through remodeling of the graft is extremely important and is provided primarily by natural tooth eruption. Thus, it is generally agreed that the optimum timing for ABG is in the mixed dentition stage (8–11 years), just before the eruption of the permanent canine in line with the cleft side [10, 13, 16, 19, 22, 23, 24, 25, 26, 27, 28, 29]. There is no precise recommended chronological age but, when one-half to two-thirds of the canine root is formed [10]. Canines are mostly the reference teeth because lateral incisors in patient with CLP are frequently absent. However, if lateral incisor is present, earlier bone grafting can be indicated at an age around 7–8 years. It has been found that the success rate is significantly reduced when ABG is performed after eruption of the canine. Resorption of the bone graft is a common situation, and the success of ABG depends on several factors. The periodontal health of the surrounding graft tissues, the experience and ability of the surgeon, and graft material are also shown to be the general factors determining success [13, 19, 20, 23, 30, 31].
\nThe importance of the orthodontist in planning, preparations, and follow-up around ABG procedure is also widely recognized. Successful alveolar bone grafting necessitates a joint orthodontic and surgical involvement pre-, peri-, and postoperatively [10, 32, 33].
\nBefore treatment, orthodontists should be able to explain the predicted outcome of bone grafting to patients and their parents [34].
\nAt that point, diagnostic information is very important for planning pre- and post-orthodontic management.
\nA bony bridge with sufficient height and width is important for successful bone grafting in the alveolar cleft and to guide eruption and movement of permanent teeth [15, 35, 36, 37]. The outcome of the procedure is considered satisfactory when a sufficient volume of remodeled bone tissue is obtained; otherwise, the surgery has to be repeated. Thus, volumetric measurements of CBCT images have been using to evaluate the success of alveolar graft outcomes in the current literature [38]. CBCT, an alternative approach to conventional CT that provides similar diagnostic information with much less radiation exposure, avoids the problems associated with traditional 2D imaging such as image enlargement and distortion, structure overlap, positional problems, and limited number of identifiable landmarks (Figure 1). It has been used to quantify the average volume of the graft, location of the bone loss, and periodontal bone support of the cleft-adjacent teeth. CBCT-derived volumetric assessment of alveolar grafts has been reported as a reliable method [24, 29, 37, 39, 40] (Figure 2). The success rate of an alveolar graft has been found to be significantly lower with volumetric evaluation than that with conventional radiographic imaging [39, 41, 42].
\nSuperimpositions on the 2D imaging might led to misdiagnosis. (a) Grafted area seems to be filled successfully on the pantomograph; (b) axial view of the CBCT image shows that graft is not successful as seen on the panoramic radiograph.
The precise volume and density can be measured by using various software.
Orthodontic treatment of patients with CLP takes much more time (is more extensive) than routine treatment because of the underlying skeletal pattern. There is no need to attempt orthodontic treatment in deciduous dentition stage. This will need much more retention procedures and will impose unnecessary burden of care [5].
\nMonitoring eruption of the teeth is important by the age 6–7.Radiographic evaluation is needed at the age of 8–9 (after eruption of upper incisors) to detect any possible teeth positioned in the cleft area and to see if lateral incisor is missing or not. If lateral incisor is present, earlier bone grafting can be planned. It is often advisable that any supplemental, deciduous teeth and also malformed and/or malpositioned lateral incisors in the cleft area should be extracted 3–4 weeks before surgery that permits healing of the mucosa (Figure 3). Thus, CBCT 6–8 months before ABG is recommended for detailed evaluation of bony support and position of the cleft-related teeth. This time frame will provide enough time to accomplish all necessary pregraft preparations such as tooth extraction and/or orthodontic tooth movement on time and not to delay bone grafting. Sometimes an additional CBCT just before the grafting might be needed to assess the root position of the cleft-related teeth after orthodonticmovement.
\nMalpositioned lateral incisor in the cleft area should be extracted 3–4 weeks before ABG.
Presurgical orthodontics plays an important role in correcting misaligned incisors or repositioning displaced maxillary alveolar segments. Severe central or canine inclination toward the cleft defect can also interfere with cleft mucoperiosteal dissection. Presurgical orthodontics allows the surgeon better access for placement of the graft and closure of the soft tissue (Figure 4). Furthermore, correction of central incisor rotation and inclination prior to SABG enables patients to achieve better oral hygiene and prevents plaque formation. This can therefore prevent chronic, low-grade inflammation activating proteases that degrade grafted bone [5, 32, 33, 38].
\nSevere canine inclination toward the cleft defect should be corrected before ABG. (a,b,c) initial views, a. intraoral, b. 3D image c. panoramik radiograph of the patient. (d,e) orthodontic traction of the cleft related canine. (f,g) pregraft 3D image and panoramic radiograph.
One of the presenting problems which occurs early in both unilateral and bilateral clefts is the anteroposterior malpositioning of the incisors. If the anteroposterior malpositioning of the incisors is not corrected, lingual lock of the anterior teeth will further inhibit the development of the maxilla. The proper overjet relationship will allow appropriate growth of the maxilla [19]. By age 7–8, incisor alignment and correction of anterior crossbite can be provided to maximize the forward development of the maxillary dentoalveolar process. However, orthodontic movement of maxillary anterior teeth must be done with great caution because of the closeness of the roots to the bony defect. A very thin bony covering of the central incisor next to the cleft site is a common feature. Often there is just a lamina dura with no cancellous bone. The incisor should not be bodily uprighted before successful ABG because of the possibility of bone loss and fenestration of the thin cortical lamina [10, 43].
\nConstriction of maxillary segments is a very common situation in patients with cleft palate. As the individuals with complete cleft lip and palate do not have midpalatal suture, constriction occurs mostly by the rotation of the lateral segment(s) inward, toward bony defect. Both the absence of the midpalatal bone and the soft tissue traction produced by lip and palate repair promote arch constriction [5, 44, 45].
\nSignificant segmental displacement requires pre-bone graft expansion to rotate the lateral segment(s) outward, facilitate placement of the graft, and provide the surgeon working facility during surgery. If possible, transverse expansion can be combined with the correction of incisor irregularities. In the mixed dentition stage, arch expansion is very important because this process also normalizes the morphology and induces eruption of the canine into the symmetrical maxillary arch [10, 13, 19, 46].
\nSeveral types of expanders have been used, and there is no universal protocol for maxillary expansion prior to secondary alveolar bone grafting (Figure 5). Both slow maxillary expansion (SME) and rapid maxillary expansion (RME) have been advocated [5, 47, 48].
\nVarious types of expanders for maxillary expansion. (a) TPA with lateral expansions, (b) quad helix, (c) NiTi expander, and (d) hyrax.
SME using the quad helix or its variations is frequently used for segmental repositioning as selective expansion anteriorly is required [5]. It has been shown that slow expansion forces are apparently already sufficient to allow a skeletal expansion of the maxilla in complete cleft palate patients [45, 47, 48]. There were
RME with Haas type or hyrax expanders is also widely used for correcting the maxillary constriction. Asymmetric expansions were found by several authors [46, 48, 49, 50, 51, 52, 53]. Isaacson and Murphy reported no correlation between the cleft location and the relative amount of lateral movement of each maxillary segment, emphasizing that RME laterally repositioned the maxillary segments in an unpredictable manner [49]. For greater amount of anterior displacement of the maxilla, fantype or double-hinged RPE expanders have been advocated [54].
\nAccording to our clinical experience, there is usually no need for RPE in patients with UCLP. Quad helix or TPA with lateral expansions can solve the problem. However, in some patients with BCLP, significant constriction of the segments necessitates RPE. Thus, patient selection is important in this issue.
\nThe quad helix and/or stabilizing archwire used in BCLP may be removed during the bone grafting procedure for improved surgical access, but these appliances should be replaced before the patient leaves the operating room and left in place for 3 months.
\nAs the bone grafting alone cannot be relied upon to maintain the expansion, a simple palatal arch would be advisable until the permanent dentition has erupted.
\nStabilizing a mobile premaxilla with orthodontic arch wire is needed in patients with complete BCLP. Typically the arch wires will be removed during surgery and replaced at the end of the operation to provide retention [5, 10, 19].
\nIf the graft is done at proper time, before eruption of the cleft-related permanent canine, observation of the permanent dentition is generally all that is necessary. The status of cleft side unerupted teeth does need careful monitoring [5]. Physiologic eruption of the adjacent canine will provide enough stimulation for the alveolar graft. Sometimes orthodontic traction might be needed if the position of the canine is not appropriate for spontaneous eruption. High degrees of canine inclination indicate risk for altered eruption and impaction [5, 32].
\nIf graft is done at age 7–8, correction of incisor irregularities provides also favorable stimulation to the graft.
\nOrthodontic movement of the cleft-adjacent teeth in the direction of the grafted bone can be instituted at an average of 3 months after the bone grafting, if needed. Combined interceptive bone grafting and orthodontic treatment at an early age avoid more extensive prolonged treatment later in the patient’s life [5, 13, 19, 34].
\nIt has been recommended not to delay orthodontic treatment more than 6 months after grafting, in cases in which an a-p crossbite or a residual transverse posterior crossbite exists. One- to two year delay in stimulation of the ABG of the premaxilla (by orthodontic treatment) can lead to serious postoperative problems. Where there is no stimulation of the graft, there tends to be “locking” or lingual collapse of the maxillary central incisors and collapse of the premaxillary arch [19].
\nIn patients with CLP, the lateral incisor is missing in about 50% of cases in the permanent dentition. There are two options when maxillary lateral incisors are absent: space closure or space preservation [5].
\nThe success of the bone graft is the determinant factor for this choice. When bone graft is properly done before the eruption of the permanent canine, canine can simultaneously migrate into the newly formed bone and increases its vertical height. Maintaining the alveolar bone height in the cleft area is important to prevent long-term complications, such as gingival retractions and periodontitis [32, 33].
\nMoreover, the natural dentition has the best prognosis for long-term health of the dentition. Thus, space closure with the canine substitution should be the first treatment choice for patients with CLP [5, 32, 33] (Figure 6). The functional stress imposed by orthodontic treatment influences the volume and prevents resorption of the grafted bone. Higher grafting success was found in the case of space closure than in the case of space openings [5, 33].
\nSpace closure with canine substitution in patient with successful ABG. (a-d) intraoral occlusal views of the case. a. pre-graft, b. post-graft, c. after eruption of the canine, d. levelling of the upper dentition. (e-h) panoramic radiographs of the case. a. pre-graft, b. post-graft, c. eruption of the canine, h. levelling of the upper arch.
However, in patients with severely impaired maxillary growth, multiple missing teeth, and/or failure of bone graft, orthodontic space closure may not be feasible, and some form of prosthesis might be needed.
\nExtraction of maxillary teeth may be required in UCLP in non-cleft quadrant, either because of crowding or to allow correction of the dental midline. As the second premolar is frequently malformed, it is the most commonly removed tooth. In some patients removal of the non-cleft lateral incisor allows the rapid restoration of the symmetry. However, this should be considered when compliance with space closure is assured [5].
\nIn the lower arch, the absence of the second premolars is frequent and should be assessed carefully where extractions are necessary to relieve lower incisor crowding.
\nExtraction of the lower teeth to compensate class III skeletal pattern should be avoided in the early teens.
\nHypoplastic maxilla and progressive midface retrusion are typical characteristics of patients with CLP.
\nTherefore, maxillary protraction (MP) has been frequently applied in the orthodontic treatment of growing patients with cleft lip and palate to improve the maxillomandibular relationship, occlusion, and facial esthetics. Optimal timing for initiating maxillary protraction for non-cleft children is shown as in the early mixed dentition before age 10. Early mixed dentition is favored over late, because of the closure of the sutures of the nasomaxillary complex [55].
\nHowever, SABG is optimally carried out between 9 and 11 years, and there is no consensus on the treatment sequencing of maxillary protraction and SABG in patients with CLP.
\nTwo studies of three-dimensional finite element analysis suggested the advantage of SABG before maxillary protraction [55, 56, 57].
\nIn a recent clinical study, short-term results showed that facemask therapy after alveolar bone grafting led to enhance maxillary skeletal advancement and minimize mandibular clockwise rotation more than those in the ungrafted group.
\nMaeda-lino found that the root lengths of U1 were comparatively short on the cleft side in patients with UCLP treated with MPA before SABG. Thus, they concluded that orthodontic force exerted by the MPA before SABG might result in short dental roots [58].
\nMoreover, it has been advocated that protraction of severely retruded cleft maxilla, even at an early stage, does not provide lasting skeletal benefit. Its effect in individual cases with CLP is difficult to predict, and many patients require orthognathic surgery after MP treatment [5, 59, 60] (Figures 7 and 8). Thus, explanation of the expected effects and associated problems should be given to the patients and parents before MP treatment.
\nFace mask application using bonded hyrax in patient with BCLP. (a) extraoral view of the patient. (b) initial lateral cephalogram.
Cephalometric radiographs of the patient after facemask therapy between 10 and 19 years of age and after orthognathic surgery. (a) age 10, after face mask therapy, (b) age 14, follow-up, (c) age 19, ğre-orthogntic surgery, (d) after orthognatic surgery.
Providing proper overjet relationship at the early mixed dentition by correcting lingual lock of the anterior teeth using either removable or fixed appliances will be sufficient to maximize the forward development of the maxillary dentoalveolar process. Facemask can be a valuable source of anchorage for advancing posterior teeth during space closure after SABG [5, 19].
\nEarly determination of the eventual need for maxillary osteotomy is a very important decision for the orthodontist.
\nExtracting lower premolar to correct anterior crossbite and trying to camouflage skeletal discrepancy are not appropriate in growing children. In that case, leveling only the upper arch, finishing with crossbite, and monitoring the growth are the best options. Early surgical options can be considered if needed [5].
\nEvaluation CBCT–maxillary expansion and/or ortho-tooth movement–fistula closure and alveolar graft–maxillary protraction if needed.
\nMaxillary protraction protocol: 350–450 gram per side protraction force is adequate 14–15 hours a day for 6–12 months. MP can be started 4–6 weeks after SABG.
\nPart of this force should be transmitted as intermittent force to the maxillary anterior teeth through oral appliances such as an arch wire and/or lingual arch.
\nIf maxillary deficiency accompanies with a wide alveolar cleft and/or fistula, it will be more challenging for both orthodontist and surgeon to treat growing patients [54] (Figure 9).
\nWide alveolar cleft limits both orthodontic treatment and maxillary osteotomy. (a, b) intraoral views of a wide cleft, (c) 3D image of the case.
Late bone grafting or prolonged orthodontic treatment prior to bone grafting leads to loss of orthodontic control, marked instability of the premaxilla, and difficulty in maintaining anteroposterior growth. In patients with BCLP, the unstable premaxilla with the small amount of maxillary bone attached to the vomer is usually incapable of being maintained with good stability without grafting.
\nWhen the premaxilla has been effectively grafted, any need to forward the maxilla at a later date can be accomplished by Le Fort osteotomy with a much diminished possibility of relapse [19].
\nThe success of the orthodontic treatment and SABG is strongly interrelated. Carefully coordinated orthodontic and surgical involvement is critical for the well-being of the patients with CLP.
\n"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
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