More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\n
Additionally, each book published by IntechOpen contains original content and research findings.
\\n\\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\n
Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\n
IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\n
Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n
\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"105",leadTitle:null,fullTitle:"Applications of Monte Carlo Methods in Biology, Medicine and Other Fields of Science",title:"Applications of Monte Carlo Methods in Biology, Medicine and Other Fields of Science",subtitle:null,reviewType:"peer-reviewed",abstract:"This volume is an eclectic mix of applications of Monte Carlo methods in many fields of research should not be surprising, because of the ubiquitous use of these methods in many fields of human endeavor. In an attempt to focus attention on a manageable set of applications, the main thrust of this book is to emphasize applications of Monte Carlo simulation methods in biology and medicine.",isbn:null,printIsbn:"978-953-307-427-6",pdfIsbn:"978-953-51-5522-5",doi:"10.5772/634",price:139,priceEur:155,priceUsd:179,slug:"applications-of-monte-carlo-methods-in-biology-medicine-and-other-fields-of-science",numberOfPages:440,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"bd43cab9801b1500af7a212d16042b05",bookSignature:"Charles J. Mode",publishedDate:"February 28th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/105.jpg",numberOfDownloads:53835,numberOfWosCitations:63,numberOfCrossrefCitations:28,numberOfCrossrefCitationsByBook:8,numberOfDimensionsCitations:71,numberOfDimensionsCitationsByBook:14,hasAltmetrics:1,numberOfTotalCitations:162,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 25th 2010",dateEndSecondStepPublish:"June 22nd 2010",dateEndThirdStepPublish:"October 27th 2010",dateEndFourthStepPublish:"November 26th 2010",dateEndFifthStepPublish:"January 25th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,10",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"21265",title:"Prof.",name:"Charles J.",middleName:null,surname:"Mode",slug:"charles-j.-mode",fullName:"Charles J. Mode",profilePictureURL:"https://mts.intechopen.com/storage/users/21265/images/1588_n.jpg",biography:"Charles J. Mode received a Ph.D. in Genetics from the University of California, Davis, which also entailed course work at the University of California, Berkeley. While at the University of California, he also studied Mathematics and Theoretical Statistics. During 1956-57 he studied Statistical Genetics while on a postdoctoral fellowship at North Carolina State University and spent the spring semester of 1957 at the University of Florida, Gainsville, teaching a course in Experimental Design to Graduate Students in Agronomy. For the rest of his active career he has served in either Departments of Mathematics or Statistics. In 1970 accepted a position in the Department of Mathematics, Drexel University, Philadelphia, Pennsylvania, where he is now a Professor Emeritus.\nHe is the author of numerous papers published in scientific journals and is also the author of three books: Multi-Type Branching Processes (1971), Stochastic Processes in Demography (1985) and Stochastic Processes in Epidemiology (2000). Throughout his career, he has maintained an interest in Genetics and Evolution and in 2004 gave a reading course in Mathematical Genetics to a talented graduate student that stimulated him to resume work in Genetics and Evolution which led him to write his latest book on Stochastic Processes in Genetics and Evolution, which will be published in 2011.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"593",title:"Biostatistics",slug:"numerical-analysis-and-scientific-computing-biostatistics"}],chapters:[{id:"13982",title:"Bias Monte Carlo Methods in Environmental Engineering",doi:"10.5772/15561",slug:"bias-monte-carlo-methods-in-environmental-engineering",totalDownloads:2147,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Albert S. Kim",downloadPdfUrl:"/chapter/pdf-download/13982",previewPdfUrl:"/chapter/pdf-preview/13982",authors:[{id:"21045",title:"Prof.",name:"Albert S.",surname:"Kim",slug:"albert-s.-kim",fullName:"Albert S. Kim"}],corrections:null},{id:"13983",title:"Monte-Carlo Simulation of a Multi-Dimensional Switch-Like Model of Stem Cell Differentiation",doi:"10.5772/15474",slug:"monte-carlo-simulation-of-a-multi-dimensional-switch-like-model-of-stem-cell-differentiation",totalDownloads:1607,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:null,signatures:"M. Andrecut",downloadPdfUrl:"/chapter/pdf-download/13983",previewPdfUrl:"/chapter/pdf-preview/13983",authors:[{id:"20958",title:"Dr.",name:"Mircea",surname:"Andrecut",slug:"mircea-andrecut",fullName:"Mircea Andrecut"}],corrections:null},{id:"13984",title:"Application of Monte Carlo Simulation and Voxel Models to Internal Dosimetry",doi:"10.5772/15197",slug:"application-of-monte-carlo-simulation-and-voxel-models-to-internal-dosimetry",totalDownloads:2656,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Sakae Kinase, Akram Mohammadi and Masa Takahashi",downloadPdfUrl:"/chapter/pdf-download/13984",previewPdfUrl:"/chapter/pdf-preview/13984",authors:[{id:"19932",title:"Prof.",name:"Sakae",surname:"Kinase",slug:"sakae-kinase",fullName:"Sakae Kinase"},{id:"24408",title:"Dr.",name:"Akram",surname:"Mohammadi",slug:"akram-mohammadi",fullName:"Akram Mohammadi"},{id:"24409",title:"Mr.",name:"Masa",surname:"Takahashi",slug:"masa-takahashi",fullName:"Masa Takahashi"}],corrections:null},{id:"13985",title:"Applications of Monte Carlo Simulation in Modelling of Biochemical Processes",doi:"10.5772/14984",slug:"applications-of-monte-carlo-simulation-in-modelling-of-biochemical-processes",totalDownloads:2650,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Kiril Ivanov Tenekedjiev, Natalia Danailova Nikolova and Krasimir Kolev",downloadPdfUrl:"/chapter/pdf-download/13985",previewPdfUrl:"/chapter/pdf-preview/13985",authors:[{id:"19421",title:"Dr.",name:"Krasimir1",surname:"Kolev",slug:"krasimir1-kolev",fullName:"Krasimir1 Kolev"},{id:"22165",title:"Dr.",name:"Kiril Ivanov",surname:"Tenekedjiev",slug:"kiril-ivanov-tenekedjiev",fullName:"Kiril Ivanov Tenekedjiev"},{id:"22166",title:"Dr.",name:"Natalia D.",surname:"Nikolova",slug:"natalia-d.-nikolova",fullName:"Natalia D. Nikolova"}],corrections:null},{id:"13986",title:"Applications to Development of PET/SPECT System by Use of Geant4",doi:"10.5772/15639",slug:"applications-to-development-of-pet-spect-system-by-use-of-geant4",totalDownloads:2373,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Yoshiyuki Hirano",downloadPdfUrl:"/chapter/pdf-download/13986",previewPdfUrl:"/chapter/pdf-preview/13986",authors:[{id:"21475",title:"Dr.",name:"Yoshiyuki",surname:"Hirano",slug:"yoshiyuki-hirano",fullName:"Yoshiyuki Hirano"}],corrections:null},{id:"13987",title:"Applying Dynamic Monte Carlo Simulation for Living Free Radical Polymerization Processes: Emphasis on Atom Transfer Radical Polymerization (ATRP)",doi:"10.5772/15897",slug:"applying-dynamic-monte-carlo-simulation-for-living-free-radical-polymerization-processes-emphasis-on",totalDownloads:2286,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Mamdouh A. Al-Harthi",downloadPdfUrl:"/chapter/pdf-download/13987",previewPdfUrl:"/chapter/pdf-preview/13987",authors:[{id:"22395",title:"Prof.",name:"Mamdouh A.",surname:"Al-Harthi",slug:"mamdouh-a.-al-harthi",fullName:"Mamdouh A. Al-Harthi"}],corrections:null},{id:"13988",title:"Monte Carlo Simulations for Beam Delivery Line Design in Radiation Therapy with Heavy Ion Beams",doi:"10.5772/15883",slug:"monte-carlo-simulations-for-beam-delivery-line-design-in-radiation-therapy-with-heavy-ion-beams",totalDownloads:2584,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Faiza Bourhaleb, Andrea Attili and Germano Russo",downloadPdfUrl:"/chapter/pdf-download/13988",previewPdfUrl:"/chapter/pdf-preview/13988",authors:[{id:"22329",title:"Dr.",name:"Faiza",surname:"Bourhaleb",slug:"faiza-bourhaleb",fullName:"Faiza Bourhaleb"},{id:"22606",title:"PhD.",name:"Andrea",surname:"Attili",slug:"andrea-attili",fullName:"Andrea Attili"}],corrections:null},{id:"13989",title:"A Monte Carlo Simulation for the Construction of Cytotoxic T Lymphocytes Repertoire",doi:"10.5772/15456",slug:"a-monte-carlo-simulation-for-the-construction-of-cytotoxic-t-lymphocytes-repertoire",totalDownloads:2012,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Filippo Castiglione",downloadPdfUrl:"/chapter/pdf-download/13989",previewPdfUrl:"/chapter/pdf-preview/13989",authors:[{id:"20879",title:"Dr.",name:"Filippo",surname:"Castiglione",slug:"filippo-castiglione",fullName:"Filippo Castiglione"}],corrections:null},{id:"13990",title:"Application of Monte Carlo Simulation in Treatment Planning for Radiation Oncology",doi:"10.5772/15068",slug:"application-of-monte-carlo-simulation-in-treatment-planning-for-radiation-oncology",totalDownloads:4027,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Kin Chan, Soo Min Heng and Robert Smee",downloadPdfUrl:"/chapter/pdf-download/13990",previewPdfUrl:"/chapter/pdf-preview/13990",authors:[{id:"19640",title:"Dr.",name:"Kin Wa",surname:"Chan",slug:"kin-wa-chan",fullName:"Kin Wa Chan"}],corrections:null},{id:"13991",title:"Dosimetric Characteristics of the Brachytherapy Sources Based on Monte Carlo Method",doi:"10.5772/15884",slug:"dosimetric-characteristics-of-the-brachytherapy-sources-based-on-monte-carlo-method",totalDownloads:3517,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Mahdi Sadeghi, Pooneh Saidi and Claudio Tenreiro",downloadPdfUrl:"/chapter/pdf-download/13991",previewPdfUrl:"/chapter/pdf-preview/13991",authors:[{id:"19676",title:"Prof.",name:"Mahdi",surname:"Sadeghi",slug:"mahdi-sadeghi",fullName:"Mahdi Sadeghi"},{id:"22336",title:"Dr.",name:"Pooneh",surname:"Saidi",slug:"pooneh-saidi",fullName:"Pooneh Saidi"},{id:"22337",title:"Prof.",name:"Claudio",surname:"Tenreiro",slug:"claudio-tenreiro",fullName:"Claudio Tenreiro"}],corrections:null},{id:"13992",title:"Evaluation of the Respiratory Motion Effect in Small Animal PET Images with GATE Monte Carlo Simulations",doi:"10.5772/15040",slug:"evaluation-of-the-respiratory-motion-effect-in-small-animal-pet-images-with-gate-monte-carlo-simulat",totalDownloads:1609,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Susana Branco, Pedro Almeida and Sébastien Jan",downloadPdfUrl:"/chapter/pdf-download/13992",previewPdfUrl:"/chapter/pdf-preview/13992",authors:[{id:"19551",title:"Ph.D.",name:"Susana",surname:"Branco",slug:"susana-branco",fullName:"Susana Branco"},{id:"19991",title:"Dr.",name:"Pedro",surname:"Almeida",slug:"pedro-almeida",fullName:"Pedro Almeida"},{id:"19993",title:"Dr.",name:"Sébastien",surname:"Jan",slug:"sebastien-jan",fullName:"Sébastien Jan"}],corrections:null},{id:"13993",title:"Fiber-optic Raman Probe Coupled with a Ball Lens for Improving Depth-resolved Raman Measurements of Epithelial Tissue: Monte Carlo Simulations",doi:"10.5772/14538",slug:"fiber-optic-raman-probe-coupled-with-a-ball-lens-for-improving-depth-resolved-raman-measurements-of-",totalDownloads:2113,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Zhiwei Huang",downloadPdfUrl:"/chapter/pdf-download/13993",previewPdfUrl:"/chapter/pdf-preview/13993",authors:[{id:"18098",title:"Prof.",name:"Zhiwei",surname:"Huang",slug:"zhiwei-huang",fullName:"Zhiwei Huang"},{id:"34316",title:"MSc",name:"Jianhua",surname:"Mo",slug:"jianhua-mo",fullName:"Jianhua Mo"},{id:"34317",title:"Dr.",name:"Wei",surname:"Zheng",slug:"wei-zheng",fullName:"Wei Zheng"}],corrections:null},{id:"13994",title:"Monte Carlo Simulations of Powerful Neutron Interaction with Matter for the Goals of Disclosure of Hidden Explosives and Fissile Materials and for Treatment of Cancer Diseases versus their Experimental Verifications",doi:"10.5772/15858",slug:"monte-carlo-simulations-of-powerful-neutron-interaction-with-matter-for-the-goals-of-disclosure-of-h",totalDownloads:2798,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"V.A. Gribkov, S.V. Latyshev, R.A. Miklaszewski, M. Chernyshova, R. Prokopowicz, M. Scholz, K. Drozdowicz, U. Wiącek, B. Gabańska, D. Dworak, K. Pytel, A. Zawadka, M. Ramos Aruca, F. Longo, G. Giannini and C. Tuniz",downloadPdfUrl:"/chapter/pdf-download/13994",previewPdfUrl:"/chapter/pdf-preview/13994",authors:[{id:"22233",title:"Prof.",name:"Vladimir",surname:"Gribkov",slug:"vladimir-gribkov",fullName:"Vladimir Gribkov"}],corrections:null},{id:"13995",title:"HERWIG: a Monte Carlo Program for QCD at LHC",doi:"10.5772/16026",slug:"herwig-a-monte-carlo-program-for-qcd-at-lhc",totalDownloads:1539,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Giuseppe Marchesini",downloadPdfUrl:"/chapter/pdf-download/13995",previewPdfUrl:"/chapter/pdf-preview/13995",authors:[{id:"22765",title:"Prof.",name:"Giuseppe",surname:"Marchesini",slug:"giuseppe-marchesini",fullName:"Giuseppe Marchesini"}],corrections:null},{id:"13996",title:"Monte Carlo Simulation of TLD Response Function: Scatterd Radiation Application",doi:"10.5772/15142",slug:"monte-carlo-simulation-of-tld-response-function-scatterd-radiation-application",totalDownloads:3070,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Seied Rabie Mahdavi, Alireza Shirazi, Ali Khodadadee, Mostafa Ghaffory and Asghar Mesbahi",downloadPdfUrl:"/chapter/pdf-download/13996",previewPdfUrl:"/chapter/pdf-preview/13996",authors:[{id:"19798",title:"PhD.",name:"Seied Rabi",surname:"Mahdavi",slug:"seied-rabi-mahdavi",fullName:"Seied Rabi Mahdavi"},{id:"19817",title:"Dr.",name:"Aliureza",surname:"Shirazi",slug:"aliureza-shirazi",fullName:"Aliureza Shirazi"},{id:"19826",title:"MSc.",name:"Mostafa",surname:"Ghaffory",slug:"mostafa-ghaffory",fullName:"Mostafa Ghaffory"},{id:"19827",title:"Dr.",name:"Asghar",surname:"Mesbahi",slug:"asghar-mesbahi",fullName:"Asghar Mesbahi"},{id:"19829",title:"BSc.",name:"Ali",surname:"Khodadadee",slug:"ali-khodadadee",fullName:"Ali Khodadadee"}],corrections:null},{id:"13997",title:"Monte Carlo Implementations of Two Sex Density Dependent Branching Processes and their Applications in Evolutionary Genetics",doi:"10.5772/15568",slug:"monte-carlo-implementations-of-two-sex-density-dependent-branching-processes-and-their-applications-",totalDownloads:1559,totalCrossrefCites:0,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Charles J. Mode, Towfique Raj and Candace K. Sleeman",downloadPdfUrl:"/chapter/pdf-download/13997",previewPdfUrl:"/chapter/pdf-preview/13997",authors:[{id:"21265",title:"Prof.",name:"Charles J.",surname:"Mode",slug:"charles-j.-mode",fullName:"Charles J. Mode"},{id:"21267",title:"Dr.",name:"Towfique",surname:"Raj",slug:"towfique-raj",fullName:"Towfique Raj"},{id:"21268",title:"Dr.",name:"Candace",surname:"Sleeman",slug:"candace-sleeman",fullName:"Candace Sleeman"}],corrections:null},{id:"13998",title:"Monte Carlo Modeling of Light Propagation in Neonatal Skin",doi:"10.5772/15853",slug:"monte-carlo-modeling-of-light-propagation-in-neonatal-skin",totalDownloads:3708,totalCrossrefCites:3,totalDimensionsCites:13,hasAltmetrics:1,abstract:null,signatures:"J.A. Delgado Atencio, S.L. Jacques and S. Vázquez y Montiel",downloadPdfUrl:"/chapter/pdf-download/13998",previewPdfUrl:"/chapter/pdf-preview/13998",authors:[{id:"22209",title:"Dr.",name:"J.A.",surname:"Delgado Atencio",slug:"j.a.-delgado-atencio",fullName:"J.A. Delgado Atencio"},{id:"54330",title:"Prof.",name:"S.L.",surname:"Jacques",slug:"s.l.-jacques",fullName:"S.L. Jacques"},{id:"54331",title:"Dr.",name:"S.",surname:"Vázquez Y Montiel",slug:"s.-vazquez-y-montiel",fullName:"S. Vázquez Y Montiel"}],corrections:null},{id:"13999",title:"Monte-Carlo Simulation of Ionizing Radiation Tracks",doi:"10.5772/15674",slug:"monte-carlo-simulation-of-ionizing-radiation-tracks",totalDownloads:3053,totalCrossrefCites:16,totalDimensionsCites:29,hasAltmetrics:0,abstract:null,signatures:"Ianik Plante and Francis A. Cucinotta",downloadPdfUrl:"/chapter/pdf-download/13999",previewPdfUrl:"/chapter/pdf-preview/13999",authors:[{id:"21574",title:"Dr.",name:"Ianik",surname:"Plante",slug:"ianik-plante",fullName:"Ianik Plante"}],corrections:null},{id:"14000",title:"Monte Carlo Simulation Tool of Evanescent Waves Spectroscopy Fiber – Optic Probe for Medical Applications (FOPS 3D)",doi:"10.5772/15831",slug:"monte-carlo-simulation-tool-of-evanescent-waves-spectroscopy-fiber-optic-probe-for-medical-applicati",totalDownloads:2119,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Daniel Khankin, Shlomo Mark and Shaul Mordechai",downloadPdfUrl:"/chapter/pdf-download/14000",previewPdfUrl:"/chapter/pdf-preview/14000",authors:[{id:"21994",title:"Prof.",name:"Shaul",surname:"Mordechai",slug:"shaul-mordechai",fullName:"Shaul Mordechai"},{id:"22151",title:"Dr.",name:"Shlomo",surname:"Mark",slug:"shlomo-mark",fullName:"Shlomo Mark"},{id:"22198",title:"Dr.",name:"Daniel",surname:"Khankin",slug:"daniel-khankin",fullName:"Daniel Khankin"}],corrections:null},{id:"14001",title:"Strain Effects in p-type Devices using Full-Band Monte Carlo Simulations",doi:"10.5772/15524",slug:"strain-effects-in-p-type-devices-using-full-band-monte-carlo-simulations",totalDownloads:1791,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Valérie Aubry-Fortuna, Karim Huet, T.T. Trang Nghiêm, Arnaud Bournel, Jérôme Saint-Martin and Philippe Dollfus",downloadPdfUrl:"/chapter/pdf-download/14001",previewPdfUrl:"/chapter/pdf-preview/14001",authors:[{id:"21133",title:"Dr.",name:"Valerie",surname:"Aubry-Fortuna",slug:"valerie-aubry-fortuna",fullName:"Valerie Aubry-Fortuna"},{id:"21134",title:"Ms.",name:"T.T. Trang",surname:"Nghiem",slug:"t.t.-trang-nghiem",fullName:"T.T. Trang Nghiem"},{id:"21135",title:"Dr.",name:"Karim",surname:"Huet",slug:"karim-huet",fullName:"Karim Huet"},{id:"21136",title:"Dr.",name:"Arnaud",surname:"Bournel",slug:"arnaud-bournel",fullName:"Arnaud Bournel"},{id:"21137",title:"Dr.",name:"Philippe",surname:"Dollfus",slug:"philippe-dollfus",fullName:"Philippe Dollfus"},{id:"21138",title:"Dr.",name:"Jérôme",surname:"Saint Martin",slug:"jerome-saint-martin",fullName:"Jérôme Saint Martin"}],corrections:null},{id:"14002",title:"Utilizing Monte Carlo Simulation for Valuation: the Case of Barrier Options under Stochastic Interest Rates",doi:"10.5772/14785",slug:"utilizing-monte-carlo-simulation-for-valuation-the-case-of-barrier-options-under-stochastic-interest",totalDownloads:2497,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Snorre Lindset",downloadPdfUrl:"/chapter/pdf-download/14002",previewPdfUrl:"/chapter/pdf-preview/14002",authors:[{id:"18720",title:"Dr.",name:"Snorre",surname:"Lindset",slug:"snorre-lindset",fullName:"Snorre Lindset"}],corrections:null},{id:"14003",title:"A rapidly Mixing Monte Carlo Method for the Simulation of Slow Molecular Processes",doi:"10.5772/15018",slug:"a-rapidly-mixing-monte-carlo-method-for-the-simulation-of-slow-molecular-processes",totalDownloads:2120,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"V. Durmaz, K. Fackeldey and M. Weber",downloadPdfUrl:"/chapter/pdf-download/14003",previewPdfUrl:"/chapter/pdf-preview/14003",authors:[{id:"19480",title:"Dr.",name:"Marcus",surname:"Weber",slug:"marcus-weber",fullName:"Marcus Weber"},{id:"21759",title:"Dr.",name:"Vedat",surname:"Durmaz",slug:"vedat-durmaz",fullName:"Vedat Durmaz"},{id:"24034",title:"Dr.",name:"Konstantin",surname:"Fackeldey",slug:"konstantin-fackeldey",fullName:"Konstantin Fackeldey"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"65667",slug:"erratum-the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",title:"Erratum - The Roll of the Entrepreneur in the Establishment of Economic Equilibria",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/65667.pdf",downloadPdfUrl:"/chapter/pdf-download/65667",previewPdfUrl:"/chapter/pdf-preview/65667",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/65667",risUrl:"/chapter/ris/65667",chapter:{id:"57461",slug:"the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",signatures:"Er’el Granot",dateSubmitted:"April 7th 2017",dateReviewed:"August 22nd 2017",datePrePublished:"December 20th 2017",datePublished:"January 24th 2018",book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"181601",title:"Prof.",name:"Er'El",middleName:null,surname:"Granot",fullName:"Er'El Granot",slug:"er'el-granot",email:"erelgranot@gmail.com",position:null,institution:{name:"Ariel University",institutionURL:null,country:{name:"Israel"}}}]}},chapter:{id:"57461",slug:"the-roll-of-the-entrepreneur-in-the-establishment-of-economic-equilibria",signatures:"Er’el Granot",dateSubmitted:"April 7th 2017",dateReviewed:"August 22nd 2017",datePrePublished:"December 20th 2017",datePublished:"January 24th 2018",book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"181601",title:"Prof.",name:"Er'El",middleName:null,surname:"Granot",fullName:"Er'El Granot",slug:"er'el-granot",email:"erelgranot@gmail.com",position:null,institution:{name:"Ariel University",institutionURL:null,country:{name:"Israel"}}}]},book:{id:"6165",title:"Entrepreneurship",subtitle:"Development Tendencies and Empirical Approach",fullTitle:"Entrepreneurship - Development Tendencies and Empirical Approach",slug:"entrepreneurship-development-tendencies-and-empirical-approach",publishedDate:"January 24th 2018",bookSignature:"Ladislav Mura",coverURL:"https://cdn.intechopen.com/books/images_new/6165.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"85474",title:"Associate Prof.",name:"Ladislav",middleName:null,surname:"Mura",slug:"ladislav-mura",fullName:"Ladislav Mura"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11714",leadTitle:null,title:"Cannabinoids - Recent Perspectives and Applications in Human Health",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThere is a great deal of confusion and controversy regarding Cannabinoids. The term "Cannabinoids" is applied to multiple chemical entities and their derivatives and metabolites isolated from the plant Cannabis sativa. Over 100 cannabinoids have been isolated to date and more are likely to be identified. Currently, they are classified into 11 different families and include delta-9 tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabigerol (CBG), Cannabichromene (CBC), and many others. Although used for varied purposes over human history, there is now great interest in the potential use of cannabinoids as novel medical therapeutics.
\r\n
\r\n\tThis book will discuss how these-plant derived compounds may potentially influence human health by interaction with the internal endocannabinoid system of animals. The evolution of cannabinoids in Cannabis sativa in the plant kingdom is separate from the development of the endocannabinoid system. These parallel histories led to the discovery that the biological activities of cannabinoids occurred through an accidental interaction with the endocannabinoid system.
\r\n
\r\n\tThis book explores the pressing controversy of whether cannabinoids enhance, or disrupt, critical physical activities essential to human health. From this discussion, the book will enable the reader to decide if cannabinoids present a promise of discoveries that lead to improved better therapeutics or a threat to the homeostasis critical for health.
",isbn:"978-1-80356-579-8",printIsbn:"978-1-80356-578-1",pdfIsbn:"978-1-80356-580-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"535e6d9b6681d78abcd0b68e02ed9bdd",bookSignature:"Dr. Steven P. James",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11714.jpg",keywords:"Cannabis, Delta-9 Tetrahydrocannabinoid (THC), Cannabidiol (CBD), Medical Marijuana, Cannabinoid 1 Receptor (CB1), Cannabinoid 2 Receptor (CB2), Anandamide (AEA), 2-Arachidonylglycerol (2-AG), K2, Nabilone, Psychedelic, Spice",numberOfDownloads:1,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 15th 2022",dateEndSecondStepPublish:"May 24th 2022",dateEndThirdStepPublish:"July 23rd 2022",dateEndFourthStepPublish:"October 11th 2022",dateEndFifthStepPublish:"December 10th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. James trained in Psychiatry at The New York Hospital, Cornell University, Westchester Division followed by a Psychopharmacology fellowship at Stanford University and a Research fellowship at the National Institute of Mental Health. After leaving his academic career, he pursued his interest in research and psychopharmacology within the pharmaceutical industry for over 20 years. He is a Fellow of both the American Psychiatric Association (APA) and the American Board of Sleep Medicine (ABSM).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"343012",title:"Dr.",name:"Steven P.",middleName:null,surname:"James",slug:"steven-p.-james",fullName:"Steven P. James",profilePictureURL:"https://mts.intechopen.com/storage/users/343012/images/system/343012.png",biography:"Steven James is the author of the recent book 'The Clinician's Guide to Cannabinoid Science' and advises pharmaceutical and health care providers on the clinical development of cannabinoid medications and their clinical uses. A cofounder of Clarity Telehealth, Dr James serves as Chief Medical Officer (CMO) and is a distinguished lifetime fellow of the American Board of Psychiatry and Neurology, and lifetime fellow of the American Board of Sleep Medicine.\nBefore publishing 'The Clinician's Guide to Cannabinoid Science', Dr. James worked for over three decades in the pharmaceutical and medical device industries including Lilly, Merck-Serono and Allergan. Before starting his career in pharmaceuticals, he trained in psychiatry at the New York-Presbyterian/Weill Cornell Medical Center and research fellowship at Stanford University School of Medicine. After training he served for three years at the National Institute of Mental Health (NIMH) and as an assistant professor at the University of Pennsylvania School of Medicine.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of California, San Diego",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:[{id:"82345",title:"Cannabis Medicines: Guidance for the Selection, Purchase and Supply for Clinical Trials",slug:"cannabis-medicines-guidance-for-the-selection-purchase-and-supply-for-clinical-trials",totalDownloads:1,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453622",firstName:"Tea",lastName:"Jurcic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"tea@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"62200",title:"OCT in Glaucoma Diagnosis, Detection and Screening",doi:"10.5772/intechopen.78683",slug:"oct-in-glaucoma-diagnosis-detection-and-screening",body:'\n
\n
1. Introduction
\n
Glaucoma is a progressive optic neuropathy where intraocular pressure is considered to be the most significant risk factor in its etiopathogenesis. The fundamental pathology of the disease is the progressive loss of the ganglion cells. Glaucoma predominantly affects the inner macular retinal layers: the macular RNFL (mRNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL) where ganglion cell complex (GCC) consists of RNFL, GCL and IPL thickness [1]. The ganglion cell damage occurs at the lamina cribrosa level in the optic disc; first, the axons get damaged, then the ganglion cells which these axons are connected to disappear through a programmed cell death called apoptosis. This loss of axons and ganglion cells cannot be identified with any clinical diagnosis methods before it exceeds a certain critical threshold [2, 3, 4, 5]. Research in this area shows that the earliest symptom that can be detected clinically in glaucoma is the loss or thinning of the retinal nerve fiber layer (RNFL). The loss or thinning of the neuroretinal tissue is usually detected later on [6, 7, 8].
\n
Circumpapillary RNFL (cpRNFL) and GCC thickness measurements are the parameters that have high performance in detecting glaucoma-detecting ability and are comparable to cpRNFL thickness [9, 10, 11].
\n
OCT is an imaging method that obtains high-resolution sections of biological tissues, and it is possible to simply define this mechanism as the conversion of the light that is reflected from the tissue to an image [12, 13, 14].
\n
Commonly used in the area of ophthalmology especially in the past 20 years, the optical coherence tomography (OCT) has provided significant contributions for the early diagnosis of the glaucoma disease and monitoring and analysis of the glaucoma patients [14, 15, 16, 17, 18].
\n
\n
\n
2. OCT from past to present
\n
OCT is first developed by Huang et al. in 1991, at the Massachusetts Institute of Technology in Boston [19]. Studies of Dr. Fujimoto who was an important member of the team who developed OCT, on femtosecond lasers and interferometers that can release energy in very short periods of time have been defining in terms of the development of the device [20]. The first OCT device known as the OCT-1 has been introduced by a company called Humprey, which was acquired by Carl Zeiss in 1991. In the following years, OCT-2, which had an increased resolution, and finally OCT-3 (Stratus OCT) were developed. All three devices are referred to as time domains [21, 22, 23, 24].
\n
This term is used more commonly, especially after the spectral domain (Fournier domain) OCT technology became available in 2002, in order to clarify the difference between the two technologies. OCT-3 is the last manufactured product with the time domain technology, which provides a significant increase in resolution compared to OCT-1 and OCT-2 [25, 26].
\n
Today, all OCT devices that are manufactured have the spectral domain technology. Simply put, while the operating principle of time domain OCT is associated with the delay in the reflection time of light, the actual variable in spectral domain OCT is the change in the optic frequency. The important differences between these devices that demonstrate themselves on clinical basis are the high axial resolution, being affected by eye movements at a minimum level and low artifacts. To date, axial resolution obtained through spectral domain OCT devices has reached up to a value of 3 microns, and these devices are rightfully referred to as OCTs with very high speeds and very high resolutions [27, 28].
\n
As also mentioned earlier, the OCT calculates the delay in the reflection of light from different layers of the tissue. Light reflected from the deep layers of the tissue would exhibit a longer period of delay, compared to that of the light reflected from the surface. The distribution of the intensity of the reflected light according to this period of delay is demonstrated as the axial A-mode scan. Many A-mode scans are obtained through scans across the sample, and these are converted into gray or colored scales indicating the signal intensity [29, 30].
\n
The most critical issue for the formation of the image in OCT systems is the measurement of the time difference of the lights reflecting from different tissues, that is, the reflection delay. A reference mirror which provides the time difference is available in time domain OCTs. This mobile mirror system is a factor that limits the speed of obtaining an image in OCT. In the spectral domain OCT system on the other hand, the mirror is fixed. Thanks to this feature, the mirror movement which limits the speed is avoided [31].
\n
In all OCT systems manufactured since the clinical use of the OCT technology, super luminescent diodes (SLDs) have been used as sources of light. In time domain OCT-3 whose axial resolution in the tissue is the highest, the resolution value is approximately 8–10 microns. Super luminescent diode lasers that could be different from each other but similar to each other in terms of the range of wave light emissions are also used in spectral domain OCT devices. Axial resolution in these devices has been lowered up to 3 microns [14].
\n
Thanks to the development of the spectral domain OCT technology, the speed for obtaining images has also increased and risen up to 70,000 A-mode scans per second from 400 A-mode scans (OCT-3) per second. The increase in the scan speed has lowered the amount of the artifact in the image even further [32].
\n
\n
\n
3. OCT use in glaucoma and some basic protocols
\n
There are several OCT devices working with similar principles but vary in diagnostic ability, acquisition speed and resolution. In this section, three commonly used SD-OCTs that are the Spectralis (Heidelberg Engineering, Dossenheim, Germany), the Cirrus (Carl Zeiss Meditec, Dublin, CA) and the RTVue (Optovue Inc., Fremont, CA) and their features are discussed. Several studies have addressed the diagnostic accuracy of the SD-OCTs one by one or compared them to time-domain technology [1, 14, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42].
\n
Since RNFL is, without a doubt one of the most important factors which is also discussed extensively in the literature, a comparison between the protocols through this value will be made and the diagnostic accuracy of this value will be examined [27].
\n
However, in recent studies comparing protocols on the capability of OCT in the diagnosis of glaucoma, no significant differences were observed between the protocols [14, 31, 32].
\n
\n
\n
4. A-Cirrus Zeiss glaucoma scanning protocol
\n
Cirrus TM High Definition (HD)-OCT Spectral Domain (Carl Zeiss Meditec, Dublin; CA) used for the analysis of glaucoma.
\n
At present, Cirrus high-definition (HD)-OCT is a widely used device to evaluate circumpapillary RNFL (cp-RNFL) thickness in clinical practice similarly as RTVue-100.
\n
It is possible for us to find the necessary quantitative and qualitative data for a good management of glaucoma in this OCT device. It allows us to study the morphology and manometry of the optic disc and the peripapillary nerve fibers [37].
\n
Even the first generation of these devices was able to display the retinal layers for us in vivo during the RNFL thickness measurement. In fact, many studies have shown the similarity between the OCT measurements and the histological sections. For this reason, the thickness of the RNFL is crucial for the early diagnosis of glaucoma and for being able to have an opinion on its progression [27, 29].
\n
Cirrus Zeiss TM HD-OCT is an advanced technology in glaucoma research which is easy to use. It is possible for us to obtain precise and thorough information about the peripapillary area and the RNFL with this system [38, 39]. Main scanning models are provided below.
\n
\n
4.1. Optic disc scanning
\n
Optic disc is recorded by Cirrus Zeiss TM HD-OCT within a 6x6 mm cube consisting of 200-B mode scans, each of which consists of 200-A mode scans. This area is divided into sections for analysis. (Figure 1).
\n
Figure 1.
Optic disc scanning in Cirrus Zeiss.
\n
The device automatically identifies the center of the optic disc through data in this cube and forms a 3.46 mm circle around the disc, which enables the RNFL thickness around the peripapillary ring to be analyzed and compared with normative data. The most important point here is the ability to perform RNFL analysis with a reliable level of precision repetitively, even though the optic disc is not placed in the center during the scan.
\n
Signal Power.
\n
The value of the signal power is a value between 0 and 10 for the entire scan, with 10 being the maximum value. The threshold value is 5 and signal power values lower than that represent the values that are below the acceptable threshold value. In some patients, it may not be possible to obtain high signal power. In such cases, the clinician should assess whether the signal obtained for scan analyses are acceptable or not.
\n
\n
\n
4.2. Fundus image
\n
While the fundus image is being created, the fundus image obtained through scanning laser ophthalmoscopy and the OCT fundus image are superimposed. This image appears on the upper section of the RNFL analysis screen. (Figure 2) The location of the calculation ring for the temporal, superior, nasal, inferior and temporal (TSNIT) section analyses is displayed in red. The operator can adjust the location of this ring following the shot if she/he likes to; however, that is often not necessary since this task is usually performed accurately through the automatic centering functionality. The B-mode scan image is the calculation ring generated from the cube of data and is flattened for the TSNIT orientation.
\n
Figure 2.
RNFL analysis screen in Cirrus Zeiss.
\n
\n
\n
4.3. RNFL thickness map
\n
The RNFL thickness map is calculated based on all the data of the scanned cube. The color scale used here is similar to that of a topographic map, where cold colors represent thinned areas while hot colors represent thick areas. In this way, the RNFL thickness at all points of the 6 × 6 mm area can be seen. The map excludes the optic disc displayed in dark blue. (Figure 3).
\n
Figure 3.
RNFL thickness map in Cirrus Zeiss.
\n
In the color scale used to demonstrate the normal and defective areas in the RNFL, thickness of the nerve fiber layers ranging from zero (blue) to 350 μm (white) are indicated using color codes.
\n
\n
\n
4.4. Average thickness values
\n
The RNFL thickness across the TSNIT calculation ring is also displayed in a numerical chart format. In this chart, the average thickness of each point across the calculation is demonstrated for both eyes. (Figure 3) In addition, average thickness for each quadrant is also demonstrated separately and in time zones. Ultimately, in all these charts, the values of the patient are compared to normative data.
\n
\n
\n
4.5. TSNIT thickness profile
\n
The TSNIT thickness profile demonstrates the RNFL thickness for each point across the peripapillary ring and compares these values to the normative database. In these comparisons of patients in the same age group, color codes (white, green, yellow and red) are used. (Figure 3).
\n
\n
\n
4.6. The normative database for RNFL
\n
The RNFL normative database is used for glaucoma patients who are older than 18. This database allows us to compare the patient’s data in the area that we are clinically interested in, with the data of other individuals in the same age group.
\n
In order to demonstrate the normal distribution percentages of the individuals in the same age group, the RNFL normative database uses the colors as below:
\n
Red: The lowest portion of 1% with regard to all measurements is in the red zone and these indicators must be considered as abnormal.
\n
Yellow: In case the measurements are within the lowest portion of 5%, they are displayed in yellow and should be interpreted as doubtful.
\n
Green: 90% of all measurements are in this section and should be considered as normal.
\n
\n
\n
4.7. The deviation map
\n
The patient’s RNFL thickness is compared with the normative data through the deviation map. Data that are out of the range of normal values are displayed in red and yellow as described earlier.
\n
\n
\n
4.8. Analysis of the results
\n
The analysis of the results for glaucoma can be easily performed at a single glance with this device. On the first row, the fundus images are provided at the top, followed by the B-mode images of the peripapillary area neighborhood. On the second row, the map of the thickness of the nerve fibers is provided, accompanied by the deviation map indicating the difference between the normal thickness and the measured thickness. On the third row, rings indicating the thickness of the nerve fibers in the quadrants are provided. On the fourth row, a colored table where the thickness of nerve fibers is indicated in microns and that allows us to understand if the values are within the normal (green), doubtful (yellow) or pathological (red) range, thanks to different colors, is provided. In the resulting analysis, data for the right eye are provided on the left, while data for the left eye are provided on the right.
\n
In conclusion, Cirrus Zeiss TM HD-OCT device offers us good qualitative and quantitative information about the glaucomatous damage in patients [42, 43, 44]. However, the diagnosis and follow-up of glaucoma can be quite complicated at times. Therefore, since making a diagnosis with one device can mislead the physicians especially in difficult cases, comprehensive clinical exam data including the patient’s visual field must be gathered while making a diagnosis.
\n
\n
\n
\n
5. Optovue-RTVue 100 glaucoma scanning protocol
\n
In glaucoma research, four scanning models for the Optovue-RTVue spectral domain OCT (RTVue Optovue Inc. Fremont, CA) device are used.
\n
\n
5.1. Optic disc scanning
\n
The optic disc is calculated through a 6 × 6 mm cube consisting of 101 lines. 3D optic disc scanning is used especially for the formation of reference lines and the determination of optic disc veins. The 3D reference line represents the optic disc limits created automatically by a software that uses the 3D optic disc scan.
\n
\n
\n
5.2. Map of the optic disc head
\n
In this protocol, 13 circular and 9 radial scans with 1.3–4.9 mm diameters around the optic disc head are performed. These scans limit the area between the retinal pigment epithelium and the optic disc head. Here, the device automatically calculates the center of the optic disc and not the center of the scan itself. The same calculation is also automatically used in progression maps (Figure 4).
\n
Figure 4.
Optic disc head map in RTVue.
\n
The map of the optic disc head provides significant information about the morphology of the optic disc. It provides insight, especially on the cup-to-disc ratio of the optic disc, the 3.45 mm circular RNFL area whose center is the optic disc head and the RNFL area located at the rim of the optic disc, 2 mm away.
\n
\n
\n
5.3. RNFL scan
\n
This scan is used to analyze the RNFL and it has shown that RNFL parameters of the RTVue-100°CT has good specificity for the detection of glaucoma [45]. The RNFL scanning pattern completes four circular scans with diameters of 3.45 mm in 0.16 s by aiming for the optic disc head. The average of these four scans is calculated and the result is presented with normative parameters.
\n
The RNFL thickness profile at the optic disc head is the circular RNFL thickness with a diameter of 3.45 mm, which is the central optic disc and not the center of the scan itself. Ultimately, cases where the optic disc is decentralized do not affect the measurements. The RNFL thickness map is exhibited at the lower right area and the areas that are measured to be thin have a darker color while areas that are measured to be thick have a lighter color (Figure 5).
\n
Figure 5.
RNFL scan in RTVue.
\n
In the lower right section, there is the thickness profile. Here, the RNFL thickness profile is charted temporally, superiorly, nasally, inferiorly and temporally again, in that order, beginning from around the optic disc. This thickness profile is charted as a black line by being superimposed on normative data (so that values within the normal range remain in the green-shaded area, while values outside of the normal range remain in the red-shaded area). The RNFL and the optic disc head parameters are located at the left section.
\n
\n
\n
5.4. RNFL glaucoma progression report
\n
The RNFL 3.45 protocol identifies the RNFL thickness of the peripapillary area by performing circular scans with a diameter of 3.45 mm around the optic disc. What is important here is the sum of four 1024-A scans performed in 0.15 s, that is, the data of 4096 scans in total.
\n
The RNFL output is divided into three sections. In the first section, regional RNFL thickness results are demonstrated with basal RNFL values and RNFL values of each subsequent check. The second section demonstrates the comparative TSNIT chart of RNFL, which is defined by a double hump pattern. The third section includes the value chart for average, superior and inferior RNFL. In addition, it illustrates the scans for each follow-up as a table including the changes between the basal scan and the last scan calculated in microns.
\n
\n
\n
5.5. The map of the ganglion cell complex (GCC)
\n
The GCC scan has provided new parameters for the diagnosis of glaucoma. The nerve fiber layer (NFL), the ganglion cell layer and the inner plexiform layer (IPL) make up the GCC in the macular area. Today, more emphasis is placed on GCC rather than the thickness of the whole retina in the diagnosis of glaucoma [44]. In studies regarding this issue, it has been shown that glaucoma mostly thins the nerve fibers, the ganglion cells and the IPL; and the inner nuclear layer at an intermediate level and that it does not affect the outer layers [44]. The GCC study is quite useful for the early diagnosis of glaucoma and the determination of the disease’s progression, since the loss of ganglion cells occur before the visual pathway lesions and thinning of the nerve fibers [13]. RTVue, by having a mapping protocol of macular ganglion cell complex, exhibits a positive value in detecting glaucoma.
\n
The GCC thickness is defined as the distance consisting of three inner retinal layers (nerve fiber layer, ganglion cell layer and the inner plexiform layer) beginning from the inner limiting membrane and ending at the inner plexiform layer. (Figure 6) All three layers are affected in glaucoma [44].
\n
Figure 6.
Anatomy of ganglion cell complex (GCC).
\n
When the ganglion cells die, the ganglion cell layer gets thinner and when the axon nerve fiber layer which is a part of this cell is damaged, the nerve fiber layer gets thinner. The dendrites of the same cell are located at the inner plexiform layer and as this layer is affected, the inner plexiform layer gets thinner. So, the GCC scan measures the thickness of each of these three layers which are affected by the glaucoma [46].
\n
Another advantage of the GCC thickness analysis is the macula’s inclusion of the 50% of the ganglion cells in the retina. However, NFL is very thin in the macula and since NFLs change places to form a foveal cup there are none of them in the foveola. In the perifoveal region, the NFL is very thin but the ganglion cell layer and the IPL are much thicker [47, 48].
\n
The scan includes 12 vertical lines and 1 horizontal line with a length of 7 mm. These lines are placed 0.5 mm away from each other and are focused on the temporal of the 1 mm fovea so that they include as many ganglion cells as possible. With this scan, the thickness map and the abnormal changes in the inner retina can be demonstrated.
\n
The deviation map illustrates the deviations of normal values for different ages and races that are available in the normative database. The significance map reports the findings for the patient by comparing them with the normal values in the normative database on the basis of race. Red, yellow and green colors are used to note the differences in the follow-ups. It demonstrates the significance level or the statistical significance of the deviation when compared with a normal value. In short, the significance map demonstrates how significant the difference is compared to the normal value.
\n
Another parameter here is the focal loss volume (FLV), which gives us the significant loss of GCC numerically. FLV is the sum of the significant loss of GCC topography, in terms of volume and is expressed as a percentage. At the same time, FLV is the most sensitive parameter which provides the difference between normal eyes and glaucomatous eyes (it is more sensitive than the GCC thickness parameters).
\n
As it can be seen, while RTVue provides an excellent assessment of the ganglion cell layer it also allows a comparison to be made with the normal values, based on age and race. In follow-ups, progression analysis by RTVue compares the RNFL thickness measurements and the GCC map over time and thus, determines whether statistically significant changes have occurred or not [1, 26, 49].
\n
\n
\n
5.6. GCC glaucoma progression report
\n
The GCC progression report displays a total of four scans at the same time for both eyes, one of which is basal and the remaining three are for follow-ups. The output is divided into four sections. The first three sections are the GCC thickness map, the deviation map and the significance map. The GCC thickness map is the one coded with colors indicating the GCC thickness of the macular region. The deviation map is the one coded with colors indicating the loss percentages that the device determined according to the normal values based on the normative database. The significance map is the one demonstrating the statistically significant changes in comparison to the normal values by coding them in green, yellow and red colors. Finally, the fourth section includes the average, superior and inferior GCC chart. In this scan, the GCC thickness of the lower and upper hemisphere of the entire retina is scanned by excluding the foveal ring. Scan data are presented as changes between the basal scan and the last scan, calculated in microns.
\n
\n
\n
5.7. RTVue OCT normative database
\n
The normative database of RTVue OCT is the largest OCT normative database. As mentioned earlier, these databases allow to distinguish between normal cases and pathological ones. In this database, there are a total of 1600 eyes, 600 of which are from the USA and 1000 of which are from around the world. The data allow us to compare the measurements of the patients with measurements of other patients in the same age group. In the display coded with colors, green (normal), yellow (doubtful) and red (abnormal) are used.
\n
It must be noted that comparisons with normative databases are only for statistical purposes and there may be normal people with values that are outside the normal range.
\n
\n
\n
\n
6. Heidelberg spectral glaucoma scanning protocol
\n
Heidelberg Spectral Domain OCT (Spectralis, Heidelberg Engineering, Dossenheim, Germany) is an OCT device with a high scanning speed and axial resolution, allowing better reproducibility for image acquisition compared to time-domain OCT (TD-OCT) [31]. It is possible to obtain a very high-quality optic disc head image and perform peripapillary RNFL thickness analysis with this device.
\n
In scans performed circularly, the scanned areas are automatically divided into sections while the RNFL thickness is measured and compared with the values in the normative database.
\n
\n
6.1. RNFL thickness profile
\n
The OCT output in this device displays the peripapillary RNFL thickness classification by six standard pie charts:
Temporal (T)
Temporal Superior (TS)
Temporal Inferior (TI)
Nasal (N)
Nasal Superior (NS)
Nasal Inferior (NI)
\n
In the ring which is in the middle of the pie chart, the average of the circular scan (G) is provided.
\n
The chart in the lower right corner of the window demonstrates the RNFL thickness profile that has been measured through the circular scan and its comparison with the normal ranges. The black curve represents the RNFL thickness of the patient. In both charts, three colors are available where green represents the normal RNFL thickness, yellow represents the limit value and red represents the abnormal RNFL thickness (Figure 7).
\n
Figure 7.
RNFL thickness map in Heidelberg.
\n
On top of the output, the optic disc head scan and the real scan image of the optic disc head surroundings are provided, while the scanned image corresponding to the RNFL thickness chart is provided on the right side.
\n
\n
\n
6.2. RNFL monitoring
\n
Heidelberg spectral OCT obtains the changes in RNFL through time by using a special software formula and uses them for monitoring the patient. This software displays the rate of difference between the average measured thickness values for each section and the normal thickness values as a chart of change. Thanks to these software, changes that occur in the RNFL profile or the deterioration that occurs in the thickness over time can be detected at an early stage [50, 51].
\n
\n
\n
6.3. The normative database of Heidelberg spectra OCT
\n
There are 201 individuals registered in the normative database of this device, all of whom are Caucasian. Ages of these individuals range from 18 to 78, and 111 of them are male while 90 are female. The criteria for these people to be included in the database are naturally, their lack of a glaucoma history and the fact that they have normal intraocular pressure, visual field and optic disc appearance. The results have been organized as a normative database.
\n
\n
\n
6.4. Posterior pole analysis
\n
A new software called Posterior Pole Analysis is offered by the Heidelberg spectral OCT [33, 52]. Thickness of the entire posterior pole retina can be measured through this software. The posterior pole is scanned point by point, and the thickness asymmetry between the two eyes and the intraocular hemispheres are analyzed. Furthermore, the GCC loss is also assessed and findings for glaucoma at an early stage are analyzed through this software [53, 54].
\n
OCT output for the analysis provides two basic maps. The first one is the map of hemisphere asymmetry while the second one is the map of RNFL thickness. The map of hemisphere asymmetry is in the form a grid where the average thicknesses of the upper and lower hemisphere are compared. Here, the squares that vertically have the same distance from the axe between the fovea and the optic disc are compared. While the squares in the upper half of the grid represent the differences between the RNFL thickness values in the superior and inferior regions, squares in the lower half represent the differences between the RNFL thickness values in the inferior and superior regions. If the difference between these values is zero or a positive value, the colored area looks white. If the area is dark gray or black, this refers to a local asymmetry in terms of RNFL thickness values.
\n
In the literature, there are several studies evaluating the diagnostic ability of abovementioned devices with some minor differences in the results [1, 2, 6, 10, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41].
\n
Leung et al. reported that, in Spectralis, the global thickness parameter had the largest area under curve (AUC) in eyes with severe glaucoma [34]. Leite et al. reported that in Spectralis, superior quadrant RNFL followed by global RNFL, had the largest AUC and in Cirrus, global thickness was the parameter that has the largest AUC, with superior and inferior RNFL quadrants being the second and the third [54]. Park et al. and Leung et al. reported similar results with inferior, average and superior quadrant RNFL’s having the best diagnostic performance for device Cirrus as Sehi et al. [29, 30, 34].
\n
In their study, Leite et al. also showed that the diagnostic ability of all three devices for the nasal and temporal quadrants for glaucoma diagnosis was lower than the results received from the other quadrants [54]. This finding may be associated with the optic nerve damage profile in the early glaucoma where inferior and superior quadrants damaged earlier than in the nasal and temporal quadrants.
\n
Although all these three devices represent difference in axial resolution and in time of acquisition, the final diagnostic performance for detection of glaucomatous defect generally reported to be similar.
\n
Different results may of course be obtained due to different clinical settings, race differences, age and the severity of the disease.
\n
In conclusion, since glaucoma is a condition that shows variations over time, it is crucial that it should be closely monitored. Especially, the change of the RNFL thickness values and the values of variation for the first and last exam of the patient must be analyzed carefully.
\n
\n
\n
Acknowledgments
\n
None.
\n
Conflict of interest
No conflict of interest.
\n',keywords:"OCT, glaucoma, retinal nerve fiber layer, ganglion cell, optic nerve",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/62200.pdf",chapterXML:"https://mts.intechopen.com/source/xml/62200.xml",downloadPdfUrl:"/chapter/pdf-download/62200",previewPdfUrl:"/chapter/pdf-preview/62200",totalDownloads:1610,totalViews:654,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:42,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"April 20th 2018",dateReviewed:"May 14th 2018",datePrePublished:"November 5th 2018",datePublished:"September 19th 2018",dateFinished:"June 20th 2018",readingETA:"0",abstract:"Glaucoma is a chronic and progressive optic neuropathy in which increased intraocular pressure is the most important risk factor in the etiopathogenesis. The basic pathology is the progressive loss of retinal ganglion cells (RGCs) especially the death of the axons of ganglion cells initially (apoptosis), followed by peripapillary retinal nerve fiber layer (RNFL) defects. Since optical coherence tomography (OCT)’s first demonstration in 1991 by Huang et al. and introduction commercially in 1996, it began gaining popularity in 2000s for retinal evaluation and the detection, diagnosis, and follow-up of glaucoma. Previously available OCT instruments used a technique referred to as time-domain (TD-) OCT, followed by spectral-domain (SD-) OCT, which has an increased scan acquisition rate, allowing for a more detailed sampling of the area of interest. Recently, swept-source OCT (SS-OCT), a newer generation of OCT, has been introduced. Clinical assessment using multiple parameters, including peripapillary RNFL, ganglion cells, optic nerve head, and macular parameters, has proven useful for managing and diagnosing glaucoma as well as for evaluating risk in glaucoma suspects. In this chapter, we aim to evaluate the use of OCT and its modalities in diagnosis, screening, and progression of glaucoma.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/62200",risUrl:"/chapter/ris/62200",book:{id:"7218",slug:"oct-applications-in-ophthalmology"},signatures:"Aydin Yildiz",authors:[{id:"255594",title:"M.D.",name:"Aydin",middleName:null,surname:"Yildiz",fullName:"Aydin Yildiz",slug:"aydin-yildiz",email:"aydinyildiz@comu.edu.tr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. OCT from past to present",level:"1"},{id:"sec_3",title:"3. OCT use in glaucoma and some basic protocols",level:"1"},{id:"sec_4",title:"4. A-Cirrus Zeiss glaucoma scanning protocol",level:"1"},{id:"sec_4_2",title:"4.1. Optic disc scanning",level:"2"},{id:"sec_5_2",title:"4.2. Fundus image",level:"2"},{id:"sec_6_2",title:"4.3. RNFL thickness map",level:"2"},{id:"sec_7_2",title:"4.4. Average thickness values",level:"2"},{id:"sec_8_2",title:"4.5. TSNIT thickness profile",level:"2"},{id:"sec_9_2",title:"4.6. The normative database for RNFL",level:"2"},{id:"sec_10_2",title:"4.7. The deviation map",level:"2"},{id:"sec_11_2",title:"4.8. Analysis of the results",level:"2"},{id:"sec_13",title:"5. Optovue-RTVue 100 glaucoma scanning protocol",level:"1"},{id:"sec_13_2",title:"5.1. Optic disc scanning",level:"2"},{id:"sec_14_2",title:"5.2. Map of the optic disc head",level:"2"},{id:"sec_15_2",title:"5.3. RNFL scan",level:"2"},{id:"sec_16_2",title:"5.4. RNFL glaucoma progression report",level:"2"},{id:"sec_17_2",title:"5.5. The map of the ganglion cell complex (GCC)",level:"2"},{id:"sec_18_2",title:"5.6. GCC glaucoma progression report",level:"2"},{id:"sec_19_2",title:"5.7. RTVue OCT normative database",level:"2"},{id:"sec_21",title:"6. Heidelberg spectral glaucoma scanning protocol",level:"1"},{id:"sec_21_2",title:"6.1. RNFL thickness profile",level:"2"},{id:"sec_22_2",title:"6.2. RNFL monitoring",level:"2"},{id:"sec_23_2",title:"6.3. The normative database of Heidelberg spectra OCT",level:"2"},{id:"sec_24_2",title:"6.4. Posterior pole analysis",level:"2"},{id:"sec_26",title:"Acknowledgments",level:"1"},{id:"sec_29",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Akashi A, Kanamori A, Nakamura M, Fujihara M, Yamada Y, Negi A. Comparative assessment for the ability of Cirrus, RTVue, and 3D-OCT to diagnose glaucoma. Investigative Ophthalmology & Visual Science. 2013;54:4478-4484\n'},{id:"B2",body:'Basic and Clinical Science Course (BCSC). Section 10: Glaucoma. San Francisco, CA: American Academy of Ophthalmology; 2016. pp. 20-38\n'},{id:"B3",body:'Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: A review. JAMA. 2014;311:1901-1911\n'},{id:"B4",body:'Medeiros FA, Alencar LM, Zangwill LM, Sample PA, Weinreb RN. The relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma. Ophthalmology. 2009;116:1125-33 e1-3\n'},{id:"B5",body:'Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Progress in Retinal and Eye Research. 2007;26:688-710\n'},{id:"B6",body:'Medeiros FA, Lisboa R, Weinreb RN, Liebmann JM, Girkin C, Zangwill LM. Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma. Ophthalmology. 2013;120:736-744\n'},{id:"B7",body:'Johnson CA, Sample PA, Zangwill LM, et al. Structure and function evaluation (SAFE): II. Comparison of optic disk and visual field characteristics. American Journal of Ophthalmology. 2003;135:148-154\n'},{id:"B8",body:'Jonas JB, Fernandez MC, Sturmer J. Pattern of glaucomatous neuroretinal rim loss. Ophthalmology. 1993;100:63-68\n'},{id:"B9",body:'Tan O, Chopra V, Lu AT. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology. 2009;116:2305-2314\n'},{id:"B10",body:'Schulze A, Lamparter J, Pfeiffer N, Berisha F, Schmidtmann I, Hoffmann EM. Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography. Graefe\'s Archive for Clinical and Experimental Ophthalmology. 2011;249:1039-1045\n'},{id:"B11",body:'Garas A, Vargha P, Hollo G. Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma. Eye (London, England). 2011;25:57-65\n'},{id:"B12",body:'Pederson JE, Anderson DR. The mode of progressive disc cupping in ocular hypertension and glaucoma. Archives of Ophthalmology. 1980;98:490-495\n'},{id:"B13",body:'Hood DC, Raza AS, de Moraes CG, Liebmann JM, Ritch R. Glaucomatous damage of the macula. Progress in Retinal and Eye Research. 2013;32:1-211\n'},{id:"B14",body:'Leung CK, Cheung CY, Weinreb RN, et al. Evaluation of retinal nerve fiber layer progression in glaucoma: A study on optical coherence tomography guided progression analysis. Investigative Ophthalmology & Visual Science. 2010;51:217-222\n'},{id:"B15",body:'Medeiros FA, Alencar LM, Zangwill LM, Bowd C, Sample PA, Weinreb RN. Prediction of functional loss in glaucoma from progressive optic disc damage. Archives of Ophthalmology. 2009;127:1250-1256\n'},{id:"B16",body:'Wollstein G, Schuman JS, Price LL, et al. Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. Archives of Ophthalmology. 2005;123:464-470\n'},{id:"B17",body:'Jaffe GJ, Caprioli J. Optical coherence tomography to detect and manage retinal disease and glaucoma. American Journal of Ophthalmology. 2004;137:156-169\n'},{id:"B18",body:'Manassakorn A, Nouri-Mahdavi K, Caprioli J. Comparison of retinal nerve fiber layer thickness and optic disk algorithms with optical coherence tomography to detect glaucoma. American Journal of Ophthalmology. 2006;141:105-115\n'},{id:"B19",body:'Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, et al. Optical coherence tomography. Science. 1991;254:1178-1181\n'},{id:"B20",body:'Fujimoto JG, Pitris C, Boppart SA, Brezinski ME. Optical coherence tomography: An emerging technology for biomedical imaging and optical biopsy. Neoplasia. 2000;2:9-25\n'},{id:"B21",body:'Hougaard JL, Heijl A, Bengtsson B. Glaucoma detection by stratus OCT. Journal of Glaucoma. 2007;16:302-306\n'},{id:"B22",body:'Parikh RS, Parikh S, Sekhar GC, et al. Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma. Ophthalmology. 2007;114:2238-2243\n'},{id:"B23",body:'Nouri-Mahdavi K, Nikkhou K, Hoffman DC, Law SK, Caprioli J. Detection of early glaucoma with optical coherence tomography (Stratus OCT). Journal of Glaucoma. 2008;17:183-188\n'},{id:"B24",body:'Lee EJ, Kim TW, Park KH, Seong M, Kim H, Kim DM. Ability of stratus OCT to detect progressive retinal nerve fiber layer atrophy in glaucoma. Investigative Ophthalmology & Visual Science. 2009;50:662-668\n'},{id:"B25",body:'Medeiros FA, Zangwill LM, Alencar LM, et al. Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements. Investigative Ophthalmology & Visual Science. 2009;50:5741-5748\n'},{id:"B26",body:'Gonzalez-Garcia AO, Vizzeri G, Bowd C, et al. Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with stratus optical coherence tomography measurements. American Journal of Ophthalmology. 2009;147: 1067-74, 74 e1\n'},{id:"B27",body:'Sull AC, Vuong LN, Price LL, et al. Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness. Retina. 2010;30:235-245\n'},{id:"B28",body:'Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna R Jr, Weinreb RN. Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. American Journal of Ophthalmology. 2005;139:44-55\n'},{id:"B29",body:'Park SB, Sung KR, Kang SY, Kim KR, Kook MS. Comparison of glaucoma diagnostic capabilities of Cirrus HD and stratus optical coherence tomography. Archives of Ophthalmology. 2009;127:1603-1609\n'},{id:"B30",body:'Sehi M, Grewal DS, Sheets CW, Greenfield DS. Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection. American Journal of Ophthalmology. 2009;148:597-605\n'},{id:"B31",body:'Kim JS, Ishikawa H, Gabriele ML, et al. Retinal nerve fiber layer thickness measurement comparability between time domain optical coherence tomography (OCT) and spectral domain OCT. Investigative Ophthalmology & Visual Science. 2010;51:896-902\n'},{id:"B32",body:'Johnson DE, El-Defrawy SR, Almeida DR, Campbell RJ. Comparison of retinal nerve fibre layer measurements from time domain and spectral domain optical coherence tomography systems. Canadian Journal of Ophthalmology. 2009;44:562-566\n'},{id:"B33",body:'Knight OJ, Chang RT, Feuer WJ, Budenz DL. Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography. Ophthalmology. 2009;116(7):1271-1277. [PubMed: 19395086]\n'},{id:"B34",body:'Leung CK, Cheung CY, Weinreb RN, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: A variability and diagnostic performance study. Ophthalmology. 2009;116(7):1257-1263. 63, e1-2. [PubMed: 19464061]\n'},{id:"B35",body:'Sung KR, Kim DY, Park SB, Kook MS. Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and stratus optical coherence tomography. Ophthalmology. 2009;116(7):1264-1270. 70, e1. [PubMed: 19427696]\n'},{id:"B36",body:'Vizzeri G, Weinreb RN, Gonzalez-Garcia AO, et al. Agreement between spectral-domain and timedomain OCT for measuring RNFL thickness. The British Journal of Ophthalmology. 2009;93(6):775-781. [PubMed: 19304586]\n'},{id:"B37",body:'Hwang YH, Kim YY, Kim HK, Sohn YH. Ability of Cirrus high- definition spectral-domain optical coherence tomography clock- hour, deviation, and thickness maps in detecting photographic retinal nerve fiber layer abnormalities. Ophthalmology. 2013;120:1380-1387\n'},{id:"B38",body:'Kotowski J, Folio LS, Wollstein G, et al. Glaucoma discrimination of segmented Cirrus spectral domain optical coherence tomography (SD-OCT) macular scans. The British Journal of Ophthalmology. 2012;96:1420-1425\n'},{id:"B39",body:'Sung KR, Na JH, Lee Y. Glaucoma diagnostic capabilities of optic nerve head parameters as determined by Cirrus HD optical coherence tomography. Journal of Glaucoma. 2012;21:498-504\n'},{id:"B40",body:'Bengtsson B, Andersson S, Heijl A. Performance of time-domain and spectral-domain optical coherence tomography for glaucoma screening. Acta Ophthalmologica. 2012;90:310-315\n'},{id:"B41",body:'Leite MT, Zangwill LM, Weinreb RN, et al. Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis. Investigative Ophthalmology & Visual Science. 2010;51:4104-4109\n'},{id:"B42",body:'Curcio CA, Allen KA. Topography of ganglion cells in human retina. The Journal of Comparative Neurology. 1990;300:5-25\n'},{id:"B43",body:'Arintawati P, Sone T, Akita T, Tanaka J, Kiuchi Y. The applicability of ganglion cell complex parameters determined from SD-OCT images to detect glaucomatous eyes. Journal of Glaucoma. 2013;22:713-718\n'},{id:"B44",body:'Zhang C, Tatham AJ, Weinreb RN, et al. Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula. Ophthalmology. 2014;121:2371-2379\n'},{id:"B45",body:'Paul C. To assess the glaucoma diagnostic ability of Fourier domain optical coherence tomography. American Journal of Engineering Research. 2013;2(11):104-110\n'},{id:"B46",body:'Mwanza JC, Durbin MK, Budenz DL, et al. Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: Comparison with nerve fiber layer and optic nerve head. Ophthalmology. 2012;119:1151-1158\n'},{id:"B47",body:'Kim NR, Lee ES, Seong GJ, Kim JH, An HG, Kim CY. Structure- function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma. Investigative Ophthalmology & Visual Science. 2010;51:4646-4651\n'},{id:"B48",body:'Mansouri K, Leite MT, Medeiros FA, Leung CK, Weinreb RN. Assessment of rates of structural change in glaucoma using imaging technologies. Eye. 2011;25:269-277\n'},{id:"B49",body:'Cho JW, Sung KR, Lee S, et al. Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography. Investigative Ophthalmology & Visual Science. 2010;51:6401-6407\n'},{id:"B50",body:'Naithani P, Sihota R, Sony P, et al. Evaluation of optical coherence tomography and Heidelberg retinal tomography parameters in detecting early and moderate glaucoma. Investigative Ophthalmology & Visual Science. 2007;48:3138-3145\n'},{id:"B51",body:'Kim NR, Lee ES, Seong GJ, Choi EH, Hong S, Kim CY. Spectral-domain optical coherence tomography for detection of localized retinal nerve fiber layer defects in patients with open-angle glaucoma. Archives of Ophthalmology. 2010;128:1121-1128\n'},{id:"B52",body:'Rao HL, Zangwill LM, Weinreb RN, Sample PA, Alencar LM, Medeiros FA. Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. Ophthalmology. 2010;117:1692-9, 9 e1\n'},{id:"B53",body:'Grewal DS, Tanna AP. Diagnosis of glaucoma and detection of glaucoma progression using spectral domain optical coherence tomography. Current Opinion in Ophthalmology. 2013;24:150-161\n'},{id:"B54",body:'Leite MT, Rao HL, Zangwill LM, Weinreb RN, Medeiros FA. Comparison of the diagnostic accuracies of spectralis, Cirrus and RTVue optical coherence tomography devices in glaucoma. Ophthalmology. 2011 July;118(7):1334-1309\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Aydin Yildiz",address:"aydinyildiz@comu.edu.tr",affiliation:'
Department of Ophthalmology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey
'}],corrections:null},book:{id:"7218",type:"book",title:"OCT",subtitle:"Applications in Ophthalmology",fullTitle:"OCT - Applications in Ophthalmology",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",bookSignature:"Michele Lanza",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78923-755-9",printIsbn:"978-1-78923-754-2",pdfIsbn:"978-1-83881-774-9",reviewType:"peer-reviewed",numberOfWosCitations:5,isAvailableForWebshopOrdering:!0,editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1094"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"62724",type:"chapter",title:"Novel Insight into Morphological Features and Vascular Profile of Selected Macular Dystrophies Using Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography",slug:"novel-insight-into-morphological-features-and-vascular-profile-of-selected-macular-dystrophies-using",totalDownloads:1165,totalCrossrefCites:0,signatures:"Magdy Moussa and Mahmoud Leila",reviewType:"peer-reviewed",authors:[{id:"242399",title:"Prof.",name:"Magdy",middleName:null,surname:"Moussa",fullName:"Magdy Moussa",slug:"magdy-moussa"},{id:"257712",title:"Dr.",name:"Mahmoud",middleName:null,surname:"Leila",fullName:"Mahmoud Leila",slug:"mahmoud-leila"}]},{id:"61732",type:"chapter",title:"Retinal Vasculature Identification and Characterization Using OCT Imaging",slug:"retinal-vasculature-identification-and-characterization-using-oct-imaging",totalDownloads:1062,totalCrossrefCites:1,signatures:"Joaquim de Moura, Jorge Novo, José Rouco, Noelia Barreira,\nManuel Penedo and Marcos Ortega",reviewType:"peer-reviewed",authors:[{id:"30409",title:"Dr.",name:"Marcos",middleName:null,surname:"Ortega",fullName:"Marcos Ortega",slug:"marcos-ortega"},{id:"30410",title:"Prof.",name:"Manuel",middleName:null,surname:"González Penedo",fullName:"Manuel González Penedo",slug:"manuel-gonzalez-penedo"},{id:"123553",title:"Prof.",name:"Jorge",middleName:null,surname:"Novo",fullName:"Jorge Novo",slug:"jorge-novo"},{id:"123554",title:"Dr.",name:"Noelia",middleName:null,surname:"Barreira",fullName:"Noelia Barreira",slug:"noelia-barreira"},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",fullName:"Joaquim De Moura",slug:"joaquim-de-moura"},{id:"242894",title:"Dr.",name:"José",middleName:null,surname:"Rouco",fullName:"José Rouco",slug:"jose-rouco"}]},{id:"62034",type:"chapter",title:"Spectral Domain Optical Coherence Tomography in the Diagnosis and Monitoring of Diabetic Macular Edema",slug:"spectral-domain-optical-coherence-tomography-in-the-diagnosis-and-monitoring-of-diabetic-macular-ede",totalDownloads:1241,totalCrossrefCites:0,signatures:"Simona Delia Nicoară",reviewType:"peer-reviewed",authors:[{id:"87785",title:"Prof.",name:"Simona-Delia",middleName:"Delia",surname:"Nicoara",fullName:"Simona-Delia Nicoara",slug:"simona-delia-nicoara"}]},{id:"62203",type:"chapter",title:"iOCT in PVR Surgical Management",slug:"ioct-in-pvr-surgical-management",totalDownloads:935,totalCrossrefCites:0,signatures:"Salvatore Di Lauro, Salvador Pastor Idoate and Jose Carlos Pastor",reviewType:"peer-reviewed",authors:[{id:"81828",title:"Prof.",name:"Jose-Carlos",middleName:null,surname:"Pastor Jimeno",fullName:"Jose-Carlos Pastor Jimeno",slug:"jose-carlos-pastor-jimeno"},{id:"241897",title:"Ph.D.",name:"Salvador",middleName:null,surname:"Pastor Idoate",fullName:"Salvador Pastor Idoate",slug:"salvador-pastor-idoate"},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",fullName:"Salvatore Di Lauro",slug:"salvatore-di-lauro"}]},{id:"62880",type:"chapter",title:"Clinical Use of OCT in the Management of Epiretinal Membranes",slug:"clinical-use-of-oct-in-the-management-of-epiretinal-membranes",totalDownloads:1213,totalCrossrefCites:0,signatures:"Nur Acar",reviewType:"peer-reviewed",authors:[{id:"244973",title:"Prof.",name:"Nur",middleName:null,surname:"Acar",fullName:"Nur Acar",slug:"nur-acar"}]},{id:"63008",type:"chapter",title:"Optical Coherence Tomography: Essential Tool in Macular Hole Management",slug:"optical-coherence-tomography-essential-tool-in-macular-hole-management",totalDownloads:1297,totalCrossrefCites:0,signatures:"Sana I. Tinwala",reviewType:"peer-reviewed",authors:[{id:"247275",title:"Dr.",name:"Sana",middleName:null,surname:"Tinwala",fullName:"Sana Tinwala",slug:"sana-tinwala"},{id:"248157",title:"Prof.",name:"Atul",middleName:null,surname:"Kumar",fullName:"Atul Kumar",slug:"atul-kumar"}]},{id:"62419",type:"chapter",title:"Intraoperative OCT in Lamellar Corneal Transplants (DALK, DSAEK, DMEK)",slug:"intraoperative-oct-in-lamellar-corneal-transplants-dalk-dsaek-dmek-",totalDownloads:995,totalCrossrefCites:0,signatures:"Jorge Luis Domene Hinojosa, Jorge L. Domene-Hickman and Nuria\nJudith Alemán Hurtado",reviewType:"peer-reviewed",authors:[{id:"244037",title:"Dr.",name:"Jorge Luis",middleName:null,surname:"Domene",fullName:"Jorge Luis Domene",slug:"jorge-luis-domene"},{id:"248007",title:"Dr.",name:"Jorge Luis",middleName:null,surname:"Domene Hickman",fullName:"Jorge Luis Domene Hickman",slug:"jorge-luis-domene-hickman"},{id:"258512",title:"Dr.",name:"Nuria Judith",middleName:null,surname:"Aleman Hurtado",fullName:"Nuria Judith Aleman Hurtado",slug:"nuria-judith-aleman-hurtado"}]},{id:"62289",type:"chapter",title:"OCT in Lamellar Corneal Transplantation",slug:"oct-in-lamellar-corneal-transplantation",totalDownloads:1045,totalCrossrefCites:0,signatures:"Mehmet Cüneyt Özmen and Hüseyin Baran Özdemir",reviewType:"peer-reviewed",authors:[{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",fullName:"Mehmet Ozmen",slug:"mehmet-ozmen"},{id:"256970",title:"Dr.",name:"Hüseyin Baran",middleName:null,surname:"Özdemir",fullName:"Hüseyin Baran Özdemir",slug:"huseyin-baran-ozdemir"}]},{id:"61907",type:"chapter",title:"Imaging the Cornea, Anterior Chamber, and Lens in Corneal and Refractive Surgery",slug:"imaging-the-cornea-anterior-chamber-and-lens-in-corneal-and-refractive-surgery",totalDownloads:1292,totalCrossrefCites:1,signatures:"Timo Eppig, Stephanie Mäurer, Loay Daas, Berthold Seitz and\nAchim Langenbucher",reviewType:"peer-reviewed",authors:[{id:"244421",title:"Associate Prof.",name:"Timo",middleName:null,surname:"Eppig",fullName:"Timo Eppig",slug:"timo-eppig"},{id:"244423",title:"Prof.",name:"Achim",middleName:null,surname:"Langenbucher",fullName:"Achim Langenbucher",slug:"achim-langenbucher"},{id:"244424",title:"MSc.",name:"Stephanie",middleName:null,surname:"Mäurer",fullName:"Stephanie Mäurer",slug:"stephanie-maurer"},{id:"255046",title:"Mr.",name:"Loay",middleName:null,surname:"Daas",fullName:"Loay Daas",slug:"loay-daas"},{id:"255953",title:"Prof.",name:"Berthold",middleName:null,surname:"Seitz",fullName:"Berthold Seitz",slug:"berthold-seitz"}]},{id:"62200",type:"chapter",title:"OCT in Glaucoma Diagnosis, Detection and Screening",slug:"oct-in-glaucoma-diagnosis-detection-and-screening",totalDownloads:1610,totalCrossrefCites:0,signatures:"Aydin Yildiz",reviewType:"peer-reviewed",authors:[{id:"255594",title:"M.D.",name:"Aydin",middleName:null,surname:"Yildiz",fullName:"Aydin Yildiz",slug:"aydin-yildiz"}]},{id:"61354",type:"chapter",title:"OCT Application Before and After Cataract Surgery",slug:"oct-application-before-and-after-cataract-surgery",totalDownloads:1148,totalCrossrefCites:2,signatures:"Xiaogang Wang, Jing Dong, Suhua Zhang and Bin Sun",reviewType:"peer-reviewed",authors:[{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",fullName:"Xiaogang Wang",slug:"xiaogang-wang"},{id:"253583",title:"Ms.",name:"Jing",middleName:null,surname:"Dong",fullName:"Jing Dong",slug:"jing-dong"},{id:"253584",title:"Prof.",name:"Suhua",middleName:null,surname:"Zhang",fullName:"Suhua Zhang",slug:"suhua-zhang"},{id:"253585",title:"Prof.",name:"Bin",middleName:null,surname:"Sun",fullName:"Bin Sun",slug:"bin-sun"}]}]},relatedBooks:[{type:"book",id:"7858",title:"A Practical Guide to Clinical Application of OCT in Ophthalmology",subtitle:null,isOpenForSubmission:!1,hash:"8e2d479cc9258dee430f8ba4c353c468",slug:"a-practical-guide-to-clinical-application-of-oct-in-ophthalmology",bookSignature:"Michele Lanza",coverURL:"https://cdn.intechopen.com/books/images_new/7858.jpg",editedByType:"Edited by",editors:[{id:"240088",title:"Prof.",name:"Michele",surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"65756",title:"Corneal Microlayer Optical Tomography Review",slug:"corneal-microlayer-optical-tomography-review",signatures:"Vatookarn Roongpoovapatr, Jane C. Cook, Taher K. Eleiwa, Sonia H. Yoo and Mohamed Abou Shousha",authors:[null]},{id:"65406",title:"Clinical Application of Optical Coherence Tomography in the Corneal Degenerations",slug:"clinical-application-of-optical-coherence-tomography-in-the-corneal-degenerations",signatures:"Constanza Caramello Álvarez, María A. del Buey, Paula Casas, Sara Marco, Enrique Mínguez and Francisco J. Ascaso",authors:[null]},{id:"68266",title:"Intraoperative OCT for Monitoring Corneal Pachymetry during Corneal Collagen Cross-Linking for Keratoconus",slug:"intraoperative-oct-for-monitoring-corneal-pachymetry-during-corneal-collagen-cross-linking-for-kerat",signatures:"Reza Ghaffari, Hassan Hashemi and Soheila Asghari",authors:[null]},{id:"67804",title:"OCT Applications in Conjunctival Disease",slug:"oct-applications-in-conjunctival-disease",signatures:"Raffaele Piscopo, Michele Lanza, Luigi Mele and Mario Bifani Sconocchia",authors:[null]},{id:"65407",title:"New Landmarks, Signs, and Findings in Optical Coherence Tomography",slug:"new-landmarks-signs-and-findings-in-optical-coherence-tomography",signatures:"Francisco Javier Lara-Medina, Olivia Esteban, Isabel Bartolomé, C. Ispa, Javier Mateo and Francisco Javier Ascaso",authors:[null]},{id:"66639",title:"Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography in Selected Posterior Uveitides",slug:"swept-source-optical-coherence-tomography-and-optical-coherence-tomography-angiography-in-selected-p",signatures:"Magdy Moussa and Mahmoud Leila",authors:[{id:"242399",title:"Prof.",name:"Magdy",middleName:null,surname:"Moussa",fullName:"Magdy Moussa",slug:"magdy-moussa"},{id:"257712",title:"Dr.",name:"Mahmoud",middleName:null,surname:"Leila",fullName:"Mahmoud Leila",slug:"mahmoud-leila"}]},{id:"65393",title:"OCT Findings in Myopic Traction Maculopathy",slug:"oct-findings-in-myopic-traction-maculopathy",signatures:"Ramesh Venkatesh, Bharathi Bavaharan and Naresh Kumar Yadav",authors:[null]},{id:"67418",title:"Role of Optical Coherence Tomography in the Evaluation and Management of Glaucoma",slug:"role-of-optical-coherence-tomography-in-the-evaluation-and-management-of-glaucoma",signatures:"Baswati Sahoo and Julie Pegu",authors:[null]}]}],publishedBooks:[{type:"book",id:"5397",title:"Glaucoma",subtitle:"Intraocular Pressure and Aqueous Dynamics",isOpenForSubmission:!1,hash:"8d26b6bdcc6ff36340803fe74ab449e4",slug:"glaucoma-intraocular-pressure-and-aqueous-dynamics",bookSignature:"Parul Ichhpujani",coverURL:"https://cdn.intechopen.com/books/images_new/5397.jpg",editedByType:"Edited by",editors:[{id:"52530",title:"Dr.",name:"Parul",surname:"Ichhpujani",slug:"parul-ichhpujani",fullName:"Parul Ichhpujani"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7094",title:"Advances in the Diagnosis and Management of Uveitis",subtitle:null,isOpenForSubmission:!1,hash:"a81511ced9080932669447918c9b5f72",slug:"advances-in-the-diagnosis-and-management-of-uveitis",bookSignature:"Alejandro Rodriguez-Garcia and C. Stephen Foster",coverURL:"https://cdn.intechopen.com/books/images_new/7094.jpg",editedByType:"Edited by",editors:[{id:"209514",title:"Dr.",name:"Alejandro",surname:"Rodriguez-Garcia",slug:"alejandro-rodriguez-garcia",fullName:"Alejandro Rodriguez-Garcia"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",isOpenForSubmission:!1,hash:"e3a3430cdfd6999caccac933e4613885",slug:"oct-applications-in-ophthalmology",bookSignature:"Michele Lanza",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",editedByType:"Edited by",editors:[{id:"240088",title:"Prof.",name:"Michele",surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"237",title:"Astigmatism",subtitle:"Optics, Physiology and Management",isOpenForSubmission:!1,hash:"899b6b3d1d0250ee904841f62bac8bee",slug:"astigmatism-optics-physiology-and-management",bookSignature:"Michael Goggin",coverURL:"https://cdn.intechopen.com/books/images_new/237.jpg",editedByType:"Edited by",editors:[{id:"65903",title:"Dr.",name:"Michael",surname:"Goggin",slug:"michael-goggin",fullName:"Michael Goggin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"268",title:"Glaucoma",subtitle:"Basic and Clinical Concepts",isOpenForSubmission:!1,hash:"b9a66374f7429cc798c56e9e8149a1aa",slug:"glaucoma-basic-and-clinical-concepts",bookSignature:"Shimon Rumelt",coverURL:"https://cdn.intechopen.com/books/images_new/268.jpg",editedByType:"Edited by",editors:[{id:"54335",title:"Dr.",name:"Shimon",surname:"Rumelt",slug:"shimon-rumelt",fullName:"Shimon Rumelt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",isOpenForSubmission:!1,hash:"e3a3430cdfd6999caccac933e4613885",slug:"oct-applications-in-ophthalmology",bookSignature:"Michele Lanza",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",editedByType:"Edited by",editors:[{id:"240088",title:"Prof.",name:"Michele",surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"70425",title:"The Rise and Decline of Car Use in Beijing and Shanghai",doi:"10.5772/intechopen.90130",slug:"the-rise-and-decline-of-car-use-in-beijing-and-shanghai",body:'
1. Introduction
China has undergone rapid urban development with its national urbanisation rate surging from 10.6% in 1949 to 56.1% in 2015 [1]. As a result, urban population across the nation has increased by 10.81 million per annum in the period. Personal income, the principal economic driver of private vehicle ownership [2], has remained on a double-digit1 high-growth trajectory in most of China since 2001. Urban population growth and economic growth have thus led to growth in private ownership of passenger cars (see Figure 1).2 Besides these factors, administrative guidance and political imperatives have also significantly affected the level of automobile ownership in China [3]. However the question in this paper is whether car use is continuing to rise in key cities or whether it is following the trend in developed cities to decouple this from economic growth.
Figure 1.
Private ownership of passenger cars per 1000 people in China (unit) and its annual growth rate (%) from 1995 to 2014. Source: Compiled based on data provided by [4].
Chinese cities, along with their respective provinces, have increased in car ownership over recent years and now provincially range in car ownership from a meagre 70 per 1000 persons in Gansu up to 209 per 1000 in Beijing (2017 data), with a national average of 122 per 1000 persons (see Figure 2).3 This national level of car ownership is less than countries such as Swaziland, El Salvador, Honduras, Guyana and Azerbaijan [5]. These levels are nowhere near the car ownership levels found in cities in more developed countries. For example, in 2005–2006, privately owned cars averaged 640, 647, 522 and 463 cars per 1000 persons in American, Australian, Canadian and European cities respectively [6]. Even between China’s two most significant cities, Shanghai and Beijing, the difference is very large (113 compared to 209 cars per 1000 persons, respectively), partly due to Shanghai having implemented car management policies4 from 1994.
Figure 2.
Private ownership of passenger cars per 1000 people across China in 2017 (unit). Source: Compiled based on data provided by [7].
Thus Chinese provinces and cities, even during what could be called a rampant period of motorisation, had by 2017 not even come close to car ownership rates in more automobile-dependent regions and were even less nationally than in some significantly less developed countries.
Added to this perspective, we now find that recent car ownership growth rates are falling. The question to be addressed in this paper is therefore whether a decline in car use and a structural change is starting to occur in Beijing and Shanghai, like in many developed cities. The paper begins by examining some trends of car use in Beijing and Shanghai. It then tries to explain the reasons why car use is beginning to decline and why this could be happening at an earlier stage of economic development than in developed cities.
2. The rise and decline of car use in Beijing and Shanghai
2.1 Beijing
Beijing, like all Chinese cities, was dominated by bicycling in the twentieth century and as shown in Figure 3 had over 60% of daily trips by cycling in 1986, but this quickly was overtaken by a rapid growth in car use; these modes crossed in 2005, and from there a different story emerges that would have been expected in a rapidly emerging global city. Car use begins to plateau in the 2000s and starts declining since 2011. The growth trajectory that then takes over is transit as cycling continues to fall but then plateaus or rises slightly perhaps due to e-bikes as seen in the data below on Shanghai.
Figure 3.
Model split of daily trips (excluding walking) in Beijing (1986–2014) (%). Source: Compiled based on data provided by [8].
The Beijing transit system is shown by mode in Figure 4. The dramatic growth after 2007 that has impacted so strongly on modal share with cars is the role of the metro that continues to grow significantly right through to the most recent data. Beijing was the first city in China to inaugurate metro rail into its transport infrastructure, with the first line opening in 1969 [9]. This development was further pursued and received a promotional boost leading up to the 2008 Olympic Games held in Beijing [10]. The metro has been expanded ever since and has been embraced by the residents of Beijing with a daily patronage of around 9 million using the fast, high-quality system. This follows the rapid expansion of Beijing’s metro system from an operational length of 142 km in 2007 to 555 km by 2015. Beijing’s metro is now the second largest after Shanghai (588 km) in China [11, 12]. The metro has become a significant transport mode, though the traditional bus is still the predominant travel choice of public transport. As this is measured in boardings, it would be more favourable to the metro if passenger kilometres were used as bus trips tend to be shorter.
Figure 4.
Share of annual patronage by different public transit modes in Beijing from 1998 to 2017(%). Source: Compiled based on data provided by [13, 14].
2.2 Shanghai
Shanghai transport data are different to Beijing as they include walking as well as e-bikes besides bicycling in the modal split as set out in Figure 5. But like Beijing, Shanghai was dominated by walking and non-motorized (bicycles and e-bikes) transport in the twentieth century with over 70% of daily trips by these modes in the 1980s and 1990s. However, as in Beijing, the twenty-first century has seen a dramatic drop in these modes as car use began to grow in Shanghai. Then a plateau in car use began in the 2000s and by 2010 had peaked at less than 20% of daily trips (even lower than the 34% in Beijing). Again it would appear that transit has stemmed this car growth, though nonmotorised transport has had more growth in the latest data as well. More interesting, e-bikes have replaced bicycles as the dominant nonmotorised transport modes in China, which was well-known as the “Bicycle Kingdom” in the middle of 1980s. The actual bicycle use per day in Shanghai has decreased 70% from 2009 to 2014, while there is a sharp increase in actual use of electric bicycles by 68% during the same period.
Figure 5.
Modal split of daily trips by different transport modes in the whole city of Shanghai from 1986 to 2010 (%). Source: Compiled based on data provided by [15, 16].
Figure 6 sets out the transit data by mode in Shanghai; this again indicates the dramatic growth of the metro.5 From the 1970s through to the beginning of the 1980s, the trolley bus and bus were the main transit modes in Shanghai. The Shanghai metro began in 1993 but was quite small until it was extended for the 2010 Shanghai World Expo. It is now the world’s largest rapid transit system by route length and second largest by number of stations with 14 lines and 364 stations and a total length of 588 km. On an average workday, it carries 10 million passengers, while the record patronage was 11.3 million on April 1, 2016.
Figure 6.
Share of annual patronage by different public transit modes in Shanghai from 1995 to 2015 (%). Source: Compiled based on data provided by [17].
While private vehicle ownership in both Beijing and Shanghai is still increasing, actual automobile use as measured by modal split has in fact started declining since around 2011. Beijing went further along the automobile path than Shanghai, but both turned dramatically once a quality metro alternative was provided. Shanghai also continues to have a very high walking and nonmotorised component in its transport system (over 50% of daily trips). Both Beijing and Shanghai have much less private motorisation than would have been expected due to their rapid growth in income like other developed cities in Canada, Australia and America.
3. Contributors to the decline of car use in Beijing and Shanghai
3.1 Economic factors
Economic factors can play a more significant role in determining automobile ownership compared to actual usage due to differences in land use intensity [18]. However, most models for car use growth still assume it is driven by economic growth, especially in developing economies. Unlike automobile ownership, the actual need for automobile use has been shown to have decoupled from the financial capacity to pay for it; for example, the amount of car driving per unit of real gross domestic product (GDP) significantly declined between 1995 and 2005 in a large sample of world cities [19, 20]. Taking Beijing as an example, Figure 7, which depicts the number of passenger cars per 1000 permanent residents, a continuous growth trend is evident in tandem with the ever-increasing per capita GDP at Beijing municipal level. However, the level of private automobile use grows to the inflexion point in 2010 and then starts dropping, despite a continuing improvement in the urban economic performance of Beijing. Furthermore in Beijing, personal income generally decreases from the city centre to the city fringe, whereas the use of the automobile increases in the opposite way. This suggests other factors than economic drivers as set out in other studies [6]. In this paper we will examine cultural, political and urban fabrics as the decoupling seems to have set in well before other cities in terms of GDP levels.
Figure 7.
Comparison of per capita GDP and per capita VKT in Beijing from 2002 to 2016. Source: Compiled based on data provided by [21, 22].
3.2 Cultural and political factors
Wealth increases have certainly led to higher levels of car use in most cities over the past 100 years, but the decline in car use setting in needs further explanation. One of the other factors would appear to be a cultural and political intervention that makes other modes more attractive. The increase in public transport in Beijing was made possible largely through the priority, which the government placed on bus and train infrastructure development. This occurred at both a local and national level in accordance with the central government’s 12th Five-Year Plan (FYP) (2011–2015). As part of this shift away from the automobile, transportation demand management (TDM) initiatives were also introduced in an effort to further curb the ownership and use of private automobiles across China. These included:
Restrictions on the operation of private automobiles on certain days throughout the 2008 Olympic Games, based on licence plate end numbers
Limitations on the number of driving licences made available to the public, a process initiated in 2010
Since 2011, termination of three pro-car policies designed to help overcome the 2008 global financial crisis (GFC).
As a result of these initiatives, automobile modal split in Beijing plateaued in 2010 before starting a downward trend. This is despite an increase in private automobile ownership in Beijing which would have had the potential to counteract this fall. However, research has shown that for many Chinese urban residents, the automobile is seen more as a status symbol than an efficient means of daily transport. The new options now available would appear to be saving time compared to the highly congested road system and the decision to not build more freeways but instead to provide a better public transport option [11].
3.3 Urban form factors
Chinese cities have been historically high in density [23] and as will be shown below have been increasing in density. Urban form factors are likely therefore to be a strong explanatory factor in why both Beijing and Shanghai started declining in car use well before they were expected to do so due to usual predictions from income growth.
3.3.1 Traditional low-rise and high-density urban form and short blocks
The low-rise, high-density blocks, which characterise China’s traditional way of building local neighbourhoods6 rather than the western-style low-density and single-family detached houses, facilitate the walking-scale environments typical of Chinese cities. In particular, the mixture of residential, commercial and recreational land use within these traditional Chinese communities provides local shops, small public spaces (squares or playgrounds) and other community services. It enables these local areas to cater for their daily necessities within walking distance. The close proximity generated by the short blocks also shortens the pedestrian distance [24]. Finally, this type of urban form helps to facilitate and operate more efficient public transport for these communities. The urban density of the whole city of Beijing and Shanghai is around 50 and 70 persons per hectare in 2005, similar to some European cities and much higher than typical automobile-dependent cities in Canada, Australia and America [25].
3.3.2 Central square and linear corridor form of urban development
As well as the organic density of traditional cities, there has been a long commitment to planning the city into a central square and linear corridor. This is known as the imperial-centred and axisymmetric urban form, which is affected by the Doctrine of the Mean7 [26]. The Kao Gong Ji8 document presents a city centre based on a square or rectangular shape, a pattern that was developed during the Dynasty of Western Zhou (1046 BC–771 BC) and led to the traditional road grid. This chessboard-like urban form based on small block sizes with multiple route choices is ideally suited to walking which has dominated Chinese urban transport for thousands of years. It also laid the foundation for the later construction and development of efficient public transport corridors across many Chinese cities, and because it was dense and had relatively clear roadways, it was also suitable for the bicycle that grew rapidly in China from the end of the nineteenth century. Then when trams came, they followed these roads and took them further out into longer corridors.
When this road structure is combined with high density and mixed land uses, as it is in China, it means that the major parts of Chinese cities were fundamentally walking and transit city fabrics [6] and became an entrenched part of how cities were built in the Chinese cultural and political landscape. Automobile fabric only develops where a new kind of urban form is sought further out from the fabric already there and at considerably lower densities. This did not happen very much in China; instead, the city fabrics from the walking and transit eras were rebuilt at much higher density and followed the same corridor-based form into new areas.
3.3.3 Traditional employment system
The socialist welfare-oriented housing within walking or cycling distances of work was provided by state-owned sectors under the traditional employment system (the so-called Dan Wei in Chinese) during the period of the planned economy in China. However, the end of this system of nearby housing provision, which came with the 1978 reform and open-up process, largely destroyed what was quite a tight job-housing balance and increased the frequency and distance of the journey to work. However, they did not at any stage build urban fabric that was automobile dependent but continued to build dense, high-rise-based corridors of urban fabric.
3.3.4 Traditional acceptance of high-density living
Chinese villages, towns and cities have always been very dense. There are various theories about why density is accepted in some cultures and not others, for example, Anglo-Saxon culture has a long history of anti-density tradition which has been passed on to New World cities [6]. The theories about density in Chinese cities suggest it is a combination of their:
Military history: The need to have walled cities for security meant that a more urban culture became essential.
Religion: Confucianism has a strong emphasis on community responsibilities that build networks of close dependence within and between families.
Economy: The reality of Chinese economic history is that they have built very big centres of economic wealth based on trading textiles, handicrafts and cultural activity that could only work efficiently if it was intensively conducted.
Together these theories suggest that the Chinese economy depended on these big cities that were made of traditional walking city fabric, highly dense and mixed for many centuries, rather than being a set of low-density rural villages based around agriculture.
These various traditions and planning paradigms have resulted in the typical Chinese urban form. The central city of both Beijing and Shanghai is still a very dense urban environment of close to 250 persons per ha (characteristic of walking city fabric). The whole city, together with all its other component parts, is also getting denser despite the “urban sprawl” in outlying areas. The urban density of the whole city is more than 50 persons/ha, which is typical of European transit-oriented regions. The old walking city centres and the transit-oriented linear form of urban development together with dense land use patterns facilitate the development of public transport systems as well as walking and cycling in Beijing and Shanghai. However, especially in the superdense city centres where there is continuous rebuilding at higher densities, these areas are becoming more and more unsuitable for cars but at the same time are beyond the affordability of most citizens.
This is not just an issue in Chinese cities as the revival of the walking and transit city fabric in most developed cities is also associated with major issues surrounding equity. The newer urban areas in outlying areas created in the last 20 years to provide more affordable housing are more automobile dependent but are still nothing like the sprawling suburbs of American and Australian cities. These areas in Chinese cities are well served now by fast metro systems as well as having considerably more local services and work; however, they are clearly going to have more car use than the traditional areas and will need to find new ways of dealing with this. For example, the lowest densities are the outer suburbs in Beijing, but even here these are above 25 persons/ha, which is the high end of auto city fabric. These areas do not go down to typical auto city densities of 7–20 persons/ha or so, but they will still need to continue to minimise such areas if they are to keep reducing their car use.
The same kind of urban fabric can be found in both cities examined; the key differences were much higher urban density in some districts of the central city and a more walkable form of urban development in Shanghai compared to Beijing. The urban density of both central cities is similarly more than 200 persons/ha. However, the urban density of the whole city and suburb areas is higher in Shanghai than in Beijing. This is perhaps due to Beijing’s scattered urban areas around the ring roads. Some districts of the central city of Shanghai are superdense with more than 600 persons/ha urban density (like Huangpu, Luwan, Jing’an and Hongkou), while the highest urban density in Beijing is around 300 persons/ha. Shanghai’s superdense urban form results in the dominance of walking and nonmotorised transport modes in the whole city.
4. Conclusions
Beijing and Shanghai are the two most representative cities in China in terms of their political, economic and cultural influences so it is very significant that both are now indicating a peak in car use has happened. This coincides with major investments in public transport that have provided an option surpassing many car use patterns. This has happened despite increasing economic growth and car ownership growth. To explain this needs an understanding of the fabrics that define the city and which are expressions of the cultural and political history of China. Both cities feature Chinese traditional urban fabrics of walking centres with transit linear corridors all with dense, mixed land use patterns that favour public transport and walking and cycling. They can both be termed “emerging transit metropolises” as opposed to the mature transit metropolises such as London and Paris [27]. These areas are also where the major job growth and urban activity are focused and thus private vehicle use has decoupled from wealth and has now peaked in terms of modal split. This paper suggests that this is strongly affected by their walking and transit urban fabrics, which are not built for much car use. More than likely the response will be to continue the peak car use trend and enable Chinese cities to become more and more a model for any other emerging cities that are trying to face up to a future with less automobile dominance in their cities.
Acknowledgments
This document was produced with the financial support of the Department of Education of Henan Province (Project No. 20B630021) and Zhengzhou University (Project No. 32220525).
Conflict of interest
The authors declare no conflict of interests.
\n',keywords:"car use, rise and decline, urban form, economic factors, cultural and political factors, Beijing, Shanghai",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70425.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70425.xml",downloadPdfUrl:"/chapter/pdf-download/70425",previewPdfUrl:"/chapter/pdf-preview/70425",totalDownloads:724,totalViews:0,totalCrossrefCites:1,dateSubmitted:"October 25th 2018",dateReviewed:"October 14th 2019",datePrePublished:"February 7th 2020",datePublished:"December 16th 2020",dateFinished:"December 12th 2019",readingETA:"0",abstract:"Chinese cities have primarily evolved around walking, bicycling and public transport with their dense, linear form and mixed land use. The recent urban growth spurt has involved private motorisation, but because of land constraints and not fearing urban density, as in Anglo-Saxon cities, the same dense urbanism has been maintained. This means that automobiles do not easily fit into this traditional fabric and especially the historic walking fabric. Issues like congestion and air quality have become major constraints to further growth. Using Beijing and Shanghai as case studies, the next phase of urban and transport development now appears to be to reduce car use with the dramatic growth in urban rail as in most developed cities in the twenty-first century. This decoupling of car use from economic growth is consistent with other developed cities but is a first for emerging cities, hence the paper aims to explain this pattern from the cultural, political and especially urban fabric perspectives. The application to other Chinese cities and emerging cities is now possible following Beijing and Shanghai’s lead.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70425",risUrl:"/chapter/ris/70425",signatures:"Yuan Gao, Peter Newman and Jeffrey Kenworthy",book:{id:"7831",type:"book",title:"Sustainability in Urban Planning and Design",subtitle:null,fullTitle:"Sustainability in Urban Planning and Design",slug:"sustainability-in-urban-planning-and-design",publishedDate:"December 16th 2020",bookSignature:"Amjad Almusaed, Asaad Almssad and Linh Truong - Hong",coverURL:"https://cdn.intechopen.com/books/images_new/7831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-352-0",printIsbn:"978-1-83880-351-3",pdfIsbn:"978-1-83969-414-1",isAvailableForWebshopOrdering:!0,editors:[{id:"110471",title:"Prof.",name:"Amjad",middleName:"Zaki",surname:"Almusaed",slug:"amjad-almusaed",fullName:"Amjad Almusaed"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"282103",title:"Dr.",name:"Yuan",middleName:null,surname:"Gao",fullName:"Yuan Gao",slug:"yuan-gao",email:"yuan.gao@curtin.edu.au",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Curtin University",institutionURL:null,country:{name:"Australia"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The rise and decline of car use in Beijing and Shanghai",level:"1"},{id:"sec_2_2",title:"2.1 Beijing",level:"2"},{id:"sec_3_2",title:"2.2 Shanghai",level:"2"},{id:"sec_5",title:"3. Contributors to the decline of car use in Beijing and Shanghai",level:"1"},{id:"sec_5_2",title:"3.1 Economic factors",level:"2"},{id:"sec_6_2",title:"3.2 Cultural and political factors",level:"2"},{id:"sec_7_2",title:"3.3 Urban form factors",level:"2"},{id:"sec_7_3",title:"3.3.1 Traditional low-rise and high-density urban form and short blocks",level:"3"},{id:"sec_8_3",title:"3.3.2 Central square and linear corridor form of urban development",level:"3"},{id:"sec_9_3",title:"3.3.3 Traditional employment system",level:"3"},{id:"sec_10_3",title:"3.3.4 Traditional acceptance of high-density living",level:"3"},{id:"sec_13",title:"4. Conclusions",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"},{id:"sec_17",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'National Bureau of Statistics of the People’s Republic of China (NBSC). 2015 Statistical Bulletin on National Economy and Social Development (Chinese Version). 2016. Available from: http://www.stats.gov.cn/tjsj/zxfb/201602/t20160229_1323991.html [Accessed: 16 March 2016]'},{id:"B2",body:'Dargay J, Gately D, Sommer M. Vehicle ownership and income growth worldwide: 1960-2030. The Energy Journal. 2007;28(4):143-170'},{id:"B3",body:'Gao Y, Kenworthy J, Newman P. Growth of a giant: A historical and current perspective on the Chinese automobile industry. World Transport Policy and Practice. 2014;21(2):40-55'},{id:"B4",body:'National Bureau of Statistics of the People’s Republic of China (NBSC). 2015 China Statistical Yearbook. Beijing, China: NBSC; 2016'},{id:"B5",body:'NationMaster Online Database. Transport > Road > Motor Vehicles per 1000 People: Countries Compared. 2016. Available from: http://www.nationmaster.com/country-info/stats/Transport/Road/Motor-vehicles-per-1000-people [Accessed: 10 May 2016]'},{id:"B6",body:'Newman P, Kenworthy J. The End of Automobile Dependence: How Cities Are Moving beyond Automobile-Based Planning. Washington DC, WA: Island Press; 2015'},{id:"B7",body:'National Bureau of Statistics of the People’s Republic of China (NBSC). 2019 China Statistical Yearbook. Beijing, China: NBSC; 2018'},{id:"B8",body:'Beijing Transportation Research Centre (BJTRC). Beijing Transport Annual Reports (Chinese Versions). 2002-2014. Available from: http://www.bjtrc.org.cn/PageLayout/ZLXZ.aspx [Accessed: 11 May 2016]'},{id:"B9",body:'Beijing Transportation Research Centre (BJTRC). Beijing Transport 2015 Annual Report (Chinese Version). BJTRC, Beijing, China. 2015. Available from: http://www.bjtrc.org.cn/InfoCenter%255CNewsAttach%255C2015年北京交通友展年披_20160303143117631.pdf [Accessed: 11 May 2016]'},{id:"B10",body:'Strickfaden M, Devlieger P.Empathy through accumulating techné: Designing and accessible metro. The Design Journal. 2011;14(2):207-229'},{id:"B11",body:'Gao Y, Newman P, Webster P. Transport transitions in Beijing: From bikes to automobiles to trains. The Journal of Sustainable Mobility. 2015;2(1):11-26'},{id:"B12",body:'Fan J, Zhang C, Lu K. Statistic and analysis on operational length of urban rail transport in China in 2015 (Chinese version). Urban Rapid Rail Transit. 2016;29(1):1-3'},{id:"B13",body:'Beijing Transportation Research Centre (BJTRC). Beijing Transport Annual Reports (Chinese Versions). 2002-2016. Available from: http://www.bjtrc.org.cn/PageLayout/ZLXZ.aspx [Accessed: 11 May 2016]'},{id:"B14",body:'Beijing Transportation Research Centre (BJTRC). Beijing Transport 2015 Annual Report (Chinese Version). BJTRC, Beijing, China. 2017. Available from: http://www.bjtrc.org.cn/InfoCenter%255CNewsAttach%255C2015年北京交通友展年披_20160303143117631.pdf [Accessed: 11 May 2016]'},{id:"B15",body:'Shanghai City Comprehensive Transportation Planning Institute (SCCTPI). 2010 Shanghai Comprehensive Transportation Annual Report (Chinese Version). Shanghai, China: SCCTPI; 2011'},{id:"B16",body:'Lu X, Liu M. Importance of public transport priority in urban cities and participation-based motivation (Chinese version). Urban Management. 2012;5:38-41'},{id:"B17",body:'Shanghai City Comprehensive Transportation Planning Institute (SCCTPI). Main Achievements of Shanghai Fifth Comprehensive Traffic Survey (Chinese Version). Shanghai, China: SCCTPI; 2015'},{id:"B18",body:'Newman P, Kenworthy J. The land use-transport connection: An overview. Land Use Policy. 1996;13(1):1-22'},{id:"B19",body:'Kenworthy J. Decoupling urban car use and metropolitan GDP growth. World Transport Policy and Practice. 2013;19(4):7-21'},{id:"B20",body:'Newman P, Kosonen L, Kenworthy J. Theory of urban fabrics: Planning the walking, transit and automobile cities for reduced automobile dependence. Town Planning Review. 2016;87(4):429-458. DOI: 10.3828/tpr.2016.28'},{id:"B21",body:'Beijing Municipal Bureau of Statistics (BJMBS). Beijing Statistical Yearbooks (Chinese Versions). 1982-2015. Available from: http://www.bjstats.gov.cn/tjsj/ndsj/ [Accessed: 25 April 2016]'},{id:"B22",body:'Beijing Municipal Bureau of Statistics (BJMBS). 2015 Beijing Statistical Yearbook (Chinese Version). BMBS, Beijing, China. 2016. Available from: http://www.bjstats.gov.cn/nj/main/2015-tjnj/zk/indexch.htm [Accessed: 25 April 2016]'},{id:"B23",body:'Kenworthy J, Hu G. Transport and urban form in Chinese cities: An international comparative and policy perspective with implications for sustainable urban transport in China. The Planning Review. 2002;38(151):12-22'},{id:"B24",body:'Ewing R, Cervero R. Travel and the built environment: A meta-analysis. Journal of the American Planning Association. 2010;76(3):265-294'},{id:"B25",body:'Gao Y, Newman P. Beijing’s peak car transition: Hope for emerging cities in the 1.5°C agenda. Urban Planning. 2018;3(2):82-93. DOI: 10.17645/up.v3i2.1246'},{id:"B26",body:'Sit V. Chinese City and Urbanism: Evolution and Development. Hackensack, NJ: World Scientific; 2010'},{id:"B27",body:'Kenworthy JR. Is Automobile Dependence in Emerging Cities an Irresistible Force? Perspectives from São Paulo, Taipei, Prague, Mumbai, Shanghai, Beijing and Guangzhou. Sustainability. 2017;9(11):1953. DOI: 10.3390/su9111953'}],footnotes:[{id:"fn1",explanation:"The growth rate of personal income was actually 8.8% in 2009."},{id:"fn2",explanation:"It includes large, medium-, small- and mini-sized passenger cars."},{id:"fn3",explanation:"Beijing and Shanghai are two of the four municipalities directly under the central government. Hence, this comparison is made with other provinces rather than cities."},{id:"fn4",explanation:"Shanghai has adopted the Singapore-style paid auction system to limit new car registration since 1994. The number of quotas issued to public applicants is less than 10,000 every month. The average bid price soared up to 5040 US Dollars in 2008."},{id:"fn5",explanation:"The sharp decrease in daily patronage by trolley bus and bus in the year of 1996 is largely due to the cancellation of monthly pass in 1995 and bus system reform in 1996."},{id:"fn6",explanation:"Local neighbourhoods in the Chinese context evolved from a quadrangle courtyard (shaped before the establishment of New China), collective compounds (dominated during planned economy before 1978 as a part of social welfare) and commercial residential buildings with entrance guard (popular in the modern economy). It is now mostly enclosed by walls or fences for privacy, security and property rights."},{id:"fn7",explanation:"The Doctrine of the Mean is one of the Four Books of Confucianism and also regarded as the highest level of moral code and natural law in China."},{id:"fn8",explanation:"This document records the specification and technology of crafts in Ancient China, playing a significant role in urban planning of Chinese cities, especially the capital cities and political cities."}],contributors:[{corresp:"yes",contributorFullName:"Yuan Gao",address:"yuan.gao@zzu.edu.cn",affiliation:'
School of Politics and Public Administration, China
Curtin University Sustainability Policy (CUSP) Institute, Curtin University, Australia
Frankfurt University of Applied Sciences, Australia
'}],corrections:null},book:{id:"7831",type:"book",title:"Sustainability in Urban Planning and Design",subtitle:null,fullTitle:"Sustainability in Urban Planning and Design",slug:"sustainability-in-urban-planning-and-design",publishedDate:"December 16th 2020",bookSignature:"Amjad Almusaed, Asaad Almssad and Linh Truong - Hong",coverURL:"https://cdn.intechopen.com/books/images_new/7831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-352-0",printIsbn:"978-1-83880-351-3",pdfIsbn:"978-1-83969-414-1",isAvailableForWebshopOrdering:!0,editors:[{id:"110471",title:"Prof.",name:"Amjad",middleName:"Zaki",surname:"Almusaed",slug:"amjad-almusaed",fullName:"Amjad Almusaed"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"190409",title:"Dr.",name:"Steve",middleName:null,surname:"Prior",email:"steve.prior@ars.usda.gov",fullName:"Steve Prior",slug:"steve-prior",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"54779",title:"Neutron-Stimulated Gamma Ray Analysis of Soil",slug:"neutron-stimulated-gamma-ray-analysis-of-soil",abstract:"This chapter describes technical aspects of neutron-stimulated gamma ray analysis of soil carbon. The introduction covers general principles, different modifications of neutron-gamma analysis, measurement system configuration, and advantages of this method for soil carbon analysis. Problems with neutron-gamma technology in soil carbon analysis and methods of investigations including Monte-Carlo simulation of neutron interaction with soil elements are discussed further. Based on the investigation results, a method of extracting the “soil carbon net peak” from the raw acquired data was developed. The direct proportional dependency between the carbon net peak area and average carbon weight percent in the upper 10 cm soil layer for any carbon depth profile was shown. Calibration of the measurement system using sand-carbon pits and field measurements of soil carbon are described. Measurement results compared to chemical analysis (dry combustion) data demonstrated good agreement between the two methods. Thus, neutron-stimulated gamma ray analysis can be used for in situ determination of near-surface soil carbon content and is applicable for precision geospatial mapping of soil carbon.",signatures:"Aleksandr Kavetskiy, Galina Yakubova, Stephen A. Prior and Henry\nAllen Torbert",authors:[{id:"38917",title:"Dr.",name:"Allen",surname:"Torbert",fullName:"Allen Torbert",slug:"allen-torbert",email:"allen.torbert@ars.usda.gov"},{id:"190407",title:"Dr.",name:"Galina",surname:"Yakubova",fullName:"Galina Yakubova",slug:"galina-yakubova",email:"Galina.Yakubova@ARS.USDA.GOV"},{id:"190408",title:"Dr.",name:"Aleksandr",surname:"Kavetskiy",fullName:"Aleksandr Kavetskiy",slug:"aleksandr-kavetskiy",email:"Aleksandr.Kavetskiy@ARS.USDA.GOV"},{id:"190409",title:"Dr.",name:"Steve",surname:"Prior",fullName:"Steve Prior",slug:"steve-prior",email:"steve.prior@ars.usda.gov"}],book:{id:"5451",title:"New Insights on Gamma Rays",slug:"new-insights-on-gamma-rays",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"147362",title:"Dr.",name:"Özge",surname:"Çelik",slug:"ozge-celik",fullName:"Özge Çelik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/147362/images/6412_n.jpg",biography:"Dr. Özge Çelik is currently working as a academic member of Department of Molecular Biology and Genetics in Istanbul Kultur University. She held the Assist. Prof. Dr. Degree at the same institute from 2010. Dr. Çelik obtained her B.Sc. from Marmara University in 2005. She obtained her Doctorate Degree from Istanbul University. Her areas of specialization include plant tissue culture, plant molecular biology and biotechnology, mutation breeding and abiotic stress tolerance. She has co-authored a laboratory book for undergraduate students titled ”Cell Biology Laboratory” with Prof. Ç.Atak. She has published over 30 papers in journals and conferences. She has been working in 4 projects as a leader and 7 projects as a researcher. She has membership in Biotechnology Federation in Turkey, EFB and FESPB. \r\nShe is also owner of an agricultural biotechnology company which is funded by The Scientific and Technological Research Council of Turkey.",institutionString:null,institution:{name:"Istanbul Kültür University",institutionURL:null,country:{name:"Turkey"}}},{id:"147364",title:"Prof.",name:"Çimen",surname:"Atak",slug:"cimen-atak",fullName:"Çimen Atak",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"189517",title:"Dr.",name:"Salih",surname:"Karabidak",slug:"salih-karabidak",fullName:"Salih Karabidak",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gümüşhane University",institutionURL:null,country:{name:"Turkey"}}},{id:"189908",title:"Dr.",name:"Carlos",surname:"Navia",slug:"carlos-navia",fullName:"Carlos Navia",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Fluminense Federal University",institutionURL:null,country:{name:"Brazil"}}},{id:"190122",title:"Dr.",name:"Houdun",surname:"Zeng",slug:"houdun-zeng",fullName:"Houdun Zeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Purple Mountain Observatory",institutionURL:null,country:{name:"China"}}},{id:"190701",title:"Dr.",name:"Matthieu",surname:"Hamel",slug:"matthieu-hamel",fullName:"Matthieu Hamel",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"194733",title:"Dr.",name:"Frédérick",surname:"Carrel",slug:"frederick-carrel",fullName:"Frédérick Carrel",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"194854",title:"Prof.",name:"Li",surname:"Zhang",slug:"li-zhang",fullName:"Li Zhang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"243084",title:"MSc.",name:"Marcel",surname:"De Oliveira",slug:"marcel-de-oliveira",fullName:"Marcel De Oliveira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"311750",title:"Dr.",name:"Markus R.",surname:"Zehringer",slug:"markus-r.-zehringer",fullName:"Markus R. Zehringer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311750/images/system/311750.jpg",biography:"Markus R. Zehringer studied chemistry at the University of Basel and finished his PhD in 1986. From 1988 to 1998 he worked as director of the environmental laboratory at the Office of Water Protection Basel-City, Switzerland. From 1998 to 2019 he was scientist and radioprotection officer at the State-Laboratory Basel-City with the main topics in radiation analyses (fallout-nuclides and radon-monitoring of dwelling houses) and trace analyses of food (pesticide-monitoring of food and monitoring of drugs in meat and fish). From 2019-2021, he worked as a radon specialist (radon analyses and sanitations) for a private company.",institutionString:"State-Laboratory Basel-City",institution:null}]},generic:{page:{slug:"open-access-funding",title:"Open Access Funding",intro:"
IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\\n\\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\\n\\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"58592",title:"Dr.",name:"Arun",middleName:null,surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58592/images/1664_n.jpg",biography:"Arun K. Shanker is serving as a Principal Scientist (Plant Physiology) with the Indian Council of Agricultural Research (ICAR) at the Central Research Institute for Dryland Agriculture in Hyderabad, India. He is working with the ICAR as a full time researcher since 1993 and has since earned his Advanced degree in Crop Physiology while in service. He has been awarded the prestigious Member of the Royal Society of Chemistry (MRSC), by the Royal Society of Chemistry, London in 2015. Presently he is working on systems biology approach to study the mechanism of abiotic stress tolerance in crops. His main focus now is to unravel the mechanism of drought and heat stress response in plants to tackle climate change related threats in agriculture.",institutionString:null,institution:{name:"Indian Council of Agricultural Research",country:{name:"India"}}},{id:"4782",title:"Prof.",name:"Bishnu",middleName:"P",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4782/images/system/4782.jpg",biography:"Bishnu P. Pal is Professor of Physics at Mahindra École\nCentrale Hyderabad India since July 1st 2014 after retirement\nas Professor of Physics from IIT Delhi; Ph.D.’1975 from IIT\nDelhi; Fellow of OSA and SPIE; Senior Member IEEE;\nHonorary Foreign Member Royal Norwegian Society for\nScience and Arts; Member OSA Board of Directors (2009-\n11); Distinguished Lecturer IEEE Photonics Society (2005-\n07).",institutionString:null,institution:{name:"Indian Institute of Technology Delhi",country:{name:"India"}}},{id:"69653",title:"Dr.",name:"Chusak",middleName:null,surname:"Limsakul",slug:"chusak-limsakul",fullName:"Chusak Limsakul",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Prince of Songkla University",country:{name:"Thailand"}}},{id:"23804",title:"Dr.",name:"Hamzah",middleName:null,surname:"Arof",slug:"hamzah-arof",fullName:"Hamzah Arof",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/23804/images/5492_n.jpg",biography:"Hamzah Arof received his BSc from Michigan State University, and PhD from the University of Wales. Both degrees were in electrical engineering. His current research interests include signal processing and photonics. Currently he is affiliated with the Department of Electrical Engineering, University of Malaya, Malaysia.",institutionString:null,institution:{name:"University of Malaya",country:{name:"Malaysia"}}},{id:"41989",title:"Prof.",name:"He",middleName:null,surname:"Tian",slug:"he-tian",fullName:"He Tian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"East China University of Science and Technology",country:{name:"China"}}},{id:"33351",title:null,name:"Hendra",middleName:null,surname:"Hermawan",slug:"hendra-hermawan",fullName:"Hendra Hermawan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/33351/images/168_n.jpg",biography:null,institutionString:null,institution:{name:"Institut Teknologi Bandung",country:{name:"Indonesia"}}},{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRglaQAC/Profile_Picture_1626411846553",biography:"Hiroshi Ishiguro is an award-winning roboticist and innovator. As the Director of the Intelligent Robotics Laboratory, which is part of the Department of Systems Innovation in the Graduate School of Engineering Science at Osaka University, Japan, Ishiguro concentrates on making robots that are similar as possible to humans to understand the human species. A notable project of his laboratory is the Actroid, a humanoid robot with a lifelike appearance and observable behavior such as facial movements. (Sources: http://www.geminoid.jp/en/index.html, https://en.wikipedia.org/wiki/Hiroshi_Ishiguro)",institutionString:null,institution:{name:"Osaka University",country:{name:"Japan"}}},{id:"45747",title:"Dr.",name:"Hsin-I",middleName:null,surname:"Chang",slug:"hsin-i-chang",fullName:"Hsin-I Chang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Chiayi University",country:{name:"Taiwan"}}},{id:"61581",title:"Dr.",name:"Joy Rizki Pangestu",middleName:null,surname:"Djuansjah",slug:"joy-rizki-pangestu-djuansjah",fullName:"Joy Rizki Pangestu Djuansjah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61581/images/237_n.jpg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"94249",title:"Prof.",name:"Junji",middleName:null,surname:"Kido",slug:"junji-kido",fullName:"Junji Kido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Yamagata University",country:{name:"Japan"}}},{id:"12009",title:"Dr.",name:"Ki Young",middleName:null,surname:"Kim",slug:"ki-young-kim",fullName:"Ki Young Kim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12009/images/system/12009.jpg",biography:"Http://m80.knu.ac.kr/~doors",institutionString:null,institution:{name:"National Cheng Kung University",country:{name:"Taiwan"}}},{id:"132595",title:"Prof.",name:"Long",middleName:null,surname:"Wang",slug:"long-wang",fullName:"Long Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Peking University",country:{name:"China"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6675},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2458},{group:"region",caption:"Asia",value:4,count:12717},{group:"region",caption:"Australia and Oceania",value:5,count:1017},{group:"region",caption:"Europe",value:6,count:17720}],offset:12,limit:12,total:12718},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"12"},books:[{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",subtitle:null,isOpenForSubmission:!0,hash:"a58c7b02d07903004be70f744f2e1835",slug:null,bookSignature:"Prof. Mohamed Nageeb Rashed and Prof. Wafaa M. Abd El-Rahim",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",editedByType:null,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11457",title:"Forest Degradation Under Global Change",subtitle:null,isOpenForSubmission:!0,hash:"8df7150b01ae754024c65d1a62f190d9",slug:null,bookSignature:"Dr. Pavel Samec",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",editedByType:null,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11650",title:"Aquifers - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"27c1a2a053cb1d83de903c5b969bc3a2",slug:null,bookSignature:"Dr. Abhay Soni and Dr. Prabhat Jain",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",editedByType:null,editors:[{id:"271093",title:"Dr.",name:"Abhay",surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11664",title:"Recent Advances in Sensing Technologies for Environmental Control and Monitoring",subtitle:null,isOpenForSubmission:!0,hash:"cf1ee76443e393bc7597723c3ee3e26f",slug:null,bookSignature:"Dr. Toonika Rinken and Dr. Kairi Kivirand",coverURL:"https://cdn.intechopen.com/books/images_new/11664.jpg",editedByType:null,editors:[{id:"24687",title:"Dr.",name:"Toonika",surname:"Rinken",slug:"toonika-rinken",fullName:"Toonika Rinken"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11665",title:"Recent Advances in Wildlife Management",subtitle:null,isOpenForSubmission:!0,hash:"73da0df494a1a56ab9c4faf2ee811899",slug:null,bookSignature:"Dr. Farzana Khan Perveen",coverURL:"https://cdn.intechopen.com/books/images_new/11665.jpg",editedByType:null,editors:[{id:"75563",title:"Dr.",name:"Farzana Khan",surname:"Perveen",slug:"farzana-khan-perveen",fullName:"Farzana Khan Perveen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c8890038b86fb6e5af16ea3c22669ae9",slug:null,bookSignature:"Dr. Adnan Mustafa and Dr. Muhammad Naveed",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",editedByType:null,editors:[{id:"299110",title:"Dr.",name:"Adnan",surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11668",title:"Mercury Pollution",subtitle:null,isOpenForSubmission:!0,hash:"0bd111f57835089cad4a9741326dbab7",slug:null,bookSignature:"Dr. Ahmed Abdelhafez and Dr. Mohamed Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",editedByType:null,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12130",title:"Sustainable Built Environment",subtitle:null,isOpenForSubmission:!0,hash:"ed1dbae71b967e06efb049208f0c1068",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12130.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12131",title:"Climate Change and Fires",subtitle:null,isOpenForSubmission:!0,hash:"ea0858f07a3e87aaf9e5eaa75b4b44bd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12131.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12180",title:"Wetlands",subtitle:null,isOpenForSubmission:!0,hash:"8957c5c2baaed32223f911a6d4aa5a03",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12180.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12221",title:"Air Pollution",subtitle:null,isOpenForSubmission:!0,hash:"439a018ee0c4960560cb798601f2a372",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12221.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:15},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4431},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"4",title:"Social Sciences and Humanities",slug:"social-sciences-and-humanities",parent:null,numberOfBooks:297,numberOfSeries:3,numberOfAuthorsAndEditors:5391,numberOfWosCitations:2993,numberOfCrossrefCitations:3111,numberOfDimensionsCitations:5701,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"4",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editedByType:"Edited by",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editedByType:"Edited by",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11258",title:"Innovation, Research and Development and Capital Evaluation",subtitle:null,isOpenForSubmission:!1,hash:"a644b267db0cddd8a16f0dfadf03bad6",slug:"innovation-research-and-development-and-capital-evaluation",bookSignature:"Luigi Aldieri",coverURL:"https://cdn.intechopen.com/books/images_new/11258.jpg",editedByType:"Edited by",editors:[{id:"246585",title:"Prof.",name:"Luigi",middleName:null,surname:"Aldieri",slug:"luigi-aldieri",fullName:"Luigi Aldieri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editedByType:"Edited by",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10889",title:"Aphasia Compendium",subtitle:null,isOpenForSubmission:!1,hash:"f2c0b1c302f68d0c86ae8e057d1cc90e",slug:"aphasia-compendium",bookSignature:"Dragoș Cătălin Jianu and Dafin Fior Mureșanu",coverURL:"https://cdn.intechopen.com/books/images_new/10889.jpg",editedByType:"Edited by",editors:[{id:"45925",title:"Prof.",name:"Dragoș",middleName:null,surname:"Cătălin Jianu",slug:"dragos-catalin-jianu",fullName:"Dragoș Cătălin Jianu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11004",title:"Medical Education for the 21st Century",subtitle:null,isOpenForSubmission:!1,hash:"f8863875cdefa578f26a438ea21bdc1e",slug:"medical-education-for-the-21st-century",bookSignature:"Michael S. Firstenberg and Stanislaw P. Stawicki",coverURL:"https://cdn.intechopen.com/books/images_new/11004.jpg",editedByType:"Edited by",editors:[{id:"64343",title:"Dr.",name:"Michael S.",middleName:null,surname:"Firstenberg",slug:"michael-s.-firstenberg",fullName:"Michael S. Firstenberg"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10207",title:"Sexual Abuse",subtitle:"An Interdisciplinary Approach",isOpenForSubmission:!1,hash:"e1ec1d5a7093490df314d7887e0b3809",slug:"sexual-abuse-an-interdisciplinary-approach",bookSignature:"Ersi Kalfoğlu and Sotirios Kalfoglou",coverURL:"https://cdn.intechopen.com/books/images_new/10207.jpg",editedByType:"Edited by",editors:[{id:"68678",title:"Dr.",name:"Ersi",middleName:null,surname:"Kalfoglou",slug:"ersi-kalfoglou",fullName:"Ersi Kalfoglou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10914",title:"Effective Elimination of Structural Racism",subtitle:null,isOpenForSubmission:!1,hash:"f6a2562646c0fd664aca8335bc3b3e69",slug:"effective-elimination-of-structural-racism",bookSignature:"Erick Guerrero",coverURL:"https://cdn.intechopen.com/books/images_new/10914.jpg",editedByType:"Edited by",editors:[{id:"294761",title:"Dr.",name:"Erick",middleName:null,surname:"Guerrero",slug:"erick-guerrero",fullName:"Erick Guerrero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10915",title:"Leadership",subtitle:"New Insights",isOpenForSubmission:!1,hash:"0d72e79892f2a020cee66a52d09de5a4",slug:"leadership-new-insights",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/10915.jpg",editedByType:"Edited by",editors:[{id:"105529",title:"Dr.",name:"Mário",middleName:null,surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",isOpenForSubmission:!1,hash:"86a6d33cf601587e591064ce92effc02",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",editedByType:"Edited by",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:297,seriesByTopicCollection:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],seriesByTopicTotal:3,mostCitedChapters:[{id:"42656",doi:"10.5772/55538",title:"Conceptual Frameworks of Vulnerability Assessments for Natural Disasters Reduction",slug:"conceptual-frameworks-of-vulnerability-assessments-for-natural-disasters-reduction",totalDownloads:9976,totalCrossrefCites:18,totalDimensionsCites:75,abstract:null,book:{id:"3054",slug:"approaches-to-disaster-management-examining-the-implications-of-hazards-emergencies-and-disasters",title:"Approaches to Disaster Management",fullTitle:"Approaches to Disaster Management - Examining the Implications of Hazards, Emergencies and Disasters"},signatures:"Roxana L. Ciurean, Dagmar Schröter and Thomas Glade",authors:[{id:"163703",title:"Prof.",name:"Thomas",middleName:null,surname:"Glade",slug:"thomas-glade",fullName:"Thomas Glade"},{id:"164141",title:"Ph.D. Student",name:"Roxana",middleName:"Liliana",surname:"Ciurean",slug:"roxana-ciurean",fullName:"Roxana Ciurean"},{id:"164142",title:"Dr.",name:"Dagmar",middleName:null,surname:"Schroeter",slug:"dagmar-schroeter",fullName:"Dagmar Schroeter"}]},{id:"58010",doi:"10.5772/intechopen.72304",title:"Fourth Industrial Revolution: Current Practices, Challenges, and Opportunities",slug:"fourth-industrial-revolution-current-practices-challenges-and-opportunities",totalDownloads:6371,totalCrossrefCites:42,totalDimensionsCites:68,abstract:"The globalization and the competitiveness are forcing companies to rethink and to innovate their production processes following the so-called Industry 4.0 paradigm. It represents the integration of tools already used in the past (big data, cloud, robot, 3D printing, simulation, etc.) that are now connected into a global network by transmitting digital data. The implementation of this new paradigm represents a huge change for companies, which are faced with big investments. In order to benefit from the opportunities offered by the smart revolution, companies must have the prerequisites needed to withstand changes generated by “smart” system. In addition, new workers who face the world of work 4.0 must have new skills in automation, digitization, and information technology, without forgetting soft skills. This chapter aims to present the main good practices, challenges, and opportunities related to Industry 4.0 paradigm.",book:{id:"6291",slug:"digital-transformation-in-smart-manufacturing",title:"Digital Transformation in Smart Manufacturing",fullTitle:"Digital Transformation in Smart Manufacturing"},signatures:"Antonella Petrillo, Fabio De Felice, Raffaele Cioffi and Federico\nZomparelli",authors:[{id:"161682",title:"Prof.",name:"Fabio",middleName:null,surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice"},{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"},{id:"205141",title:"Dr.",name:"Federico",middleName:null,surname:"Zomparelli",slug:"federico-zomparelli",fullName:"Federico Zomparelli"},{id:"208748",title:"Dr.",name:"Raffaele",middleName:null,surname:"Cioffi",slug:"raffaele-cioffi",fullName:"Raffaele Cioffi"}]},{id:"40977",doi:"10.5772/53885",title:"The Emergence of Scientific Reasoning",slug:"the-emergence-of-scientific-reasoning",totalDownloads:4520,totalCrossrefCites:8,totalDimensionsCites:58,abstract:null,book:{id:"654",slug:"current-topics-in-children-s-learning-and-cognition",title:"Current Topics in Children's Learning and Cognition",fullTitle:"Current Topics in Children's Learning and Cognition"},signatures:"Bradley J. Morris, Steve Croker, Amy M. Masnick and Corinne Zimmerman",authors:[{id:"154336",title:"Prof.",name:"Bradley",middleName:null,surname:"Morris",slug:"bradley-morris",fullName:"Bradley Morris"},{id:"154337",title:"Prof.",name:"Steve",middleName:null,surname:"Croker",slug:"steve-croker",fullName:"Steve Croker"},{id:"154338",title:"Prof.",name:"Amy",middleName:null,surname:"Masnick",slug:"amy-masnick",fullName:"Amy Masnick"},{id:"154339",title:"Prof.",name:"Corinne",middleName:null,surname:"Zimmerman",slug:"corinne-zimmerman",fullName:"Corinne Zimmerman"}]},{id:"35715",doi:"10.5772/38693",title:"The Role and Importance of Cultural Tourism in Modern Tourism Industry",slug:"the-role-and-importance-of-cultural-tourism-in-modern-tourism-industry",totalDownloads:41056,totalCrossrefCites:30,totalDimensionsCites:57,abstract:null,book:{id:"2298",slug:"strategies-for-tourism-industry-micro-and-macro-perspectives",title:"Strategies for Tourism Industry",fullTitle:"Strategies for Tourism Industry - Micro and Macro Perspectives"},signatures:"Janos Csapo",authors:[{id:"118766",title:"Dr.",name:"János",middleName:null,surname:"Csapó",slug:"janos-csapo",fullName:"János Csapó"}]},{id:"37707",doi:"10.5772/51110",title:"Principle of Meat Aroma Flavors and Future Prospect",slug:"principle-of-meat-aroma-flavors-and-future-prospect",totalDownloads:7443,totalCrossrefCites:17,totalDimensionsCites:52,abstract:null,book:{id:"3276",slug:"latest-research-into-quality-control",title:"Latest Research into Quality Control",fullTitle:"Latest Research into Quality Control"},signatures:"Hoa Van Ba, Inho Hwang, Dawoon Jeong and Amna Touseef",authors:[{id:"153361",title:"Ph.D.",name:"Hoa",middleName:null,surname:"Van Ba",slug:"hoa-van-ba",fullName:"Hoa Van Ba"},{id:"163181",title:"Prof.",name:"Touseef",middleName:null,surname:"Amna",slug:"touseef-amna",fullName:"Touseef Amna"}]}],mostDownloadedChaptersLast30Days:[{id:"58890",title:"Philosophy and Paradigm of Scientific Research",slug:"philosophy-and-paradigm-of-scientific-research",totalDownloads:13759,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"Before carrying out the empirical analysis of the role of management culture in corporate social responsibility, identification of the philosophical approach and the paradigm on which the research carried out is based is necessary. Therefore, this chapter deals with the philosophical systems and paradigms of scientific research, the epistemology, evaluating understanding and application of various theories and practices used in the scientific research. The key components of the scientific research paradigm are highlighted. Theories on the basis of which this research was focused on identification of the level of development of the management culture in order to implement corporate social responsibility are identified, and the stages of its implementation are described.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"74550",title:"School Conflicts: Causes and Management Strategies in Classroom Relationships",slug:"school-conflicts-causes-and-management-strategies-in-classroom-relationships",totalDownloads:2204,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"Conflicts cannot cease to exist, as they are intrinsic to human beings, forming an integral part of their moral and emotional growth. Likewise, they exist in all schools. The school is inserted in a space where the conflict manifests itself daily and assumes relevance, being the result of the multiple interpersonal relationships that occur in the school context. Thus, conflict is part of school life, which implies that teachers must have the skills to manage conflict constructively. Recognizing the diversity of school conflicts, this chapter aimed to present its causes, highlighting the main ones in the classroom, in the teacher-student relationship. It is important to conflict face and resolve it with skills to manage it properly and constructively, establishing cooperative relationships, and producing integrative solutions. Harmony and appreciation should coexist in a classroom environment and conflict should not interfere, negatively, in the teaching and learning process. This bibliography review underscore the need for during the teachers’ initial training the conflict management skills development.",book:{id:"7827",slug:null,title:"Interpersonal Relationships",fullTitle:"Interpersonal Relationships"},signatures:"Sabina Valente, Abílio Afonso Lourenço and Zsolt Németh",authors:null},{id:"58969",title:"Corruption, Causes and Consequences",slug:"corruption-causes-and-consequences",totalDownloads:27589,totalCrossrefCites:11,totalDimensionsCites:13,abstract:"Corruption is a constant in the society and occurs in all civilizations; however, it has only been in the past 20 years that this phenomenon has begun being seriously explored. It has many different shapes as well as many various effects, both on the economy and the society at large. Among the most common causes of corruption are the political and economic environment, professional ethics and morality and, of course, habits, customs, tradition and demography. Its effects on the economy (and also on the wider society) are well researched, yet still not completely. Corruption thus inhibits economic growth and affects business operations, employment and investments. It also reduces tax revenue and the effectiveness of various financial assistance programs. The wider society is influenced by a high degree of corruption in terms of lowering of trust in the law and the rule of law, education and consequently the quality of life (access to infrastructure, health care). There also does not exist an unambiguous answer as to how to deal with corruption. Something that works in one country or in one region will not necessarily be successful in another. This chapter tries to answer at least a few questions about corruption and the causes for it, its consequences and how to deal with it successfully.",book:{id:"6487",slug:"trade-and-global-market",title:"Trade and Global Market",fullTitle:"Trade and Global Market"},signatures:"Štefan Šumah",authors:[{id:"228073",title:"Mr.",name:"Stefan",middleName:null,surname:"Sumah",slug:"stefan-sumah",fullName:"Stefan Sumah"}]},{id:"55499",title:"Human Resources Management in Nonprofit Organizations: A Case Study of Istanbul Foundation for Culture and Arts",slug:"human-resources-management-in-nonprofit-organizations-a-case-study-of-istanbul-foundation-for-cultur",totalDownloads:2294,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study is to investigate the efficiency and importance of human resources management in nonprofit organizations. The understanding was included to the literature as personnel management at the beginning of the twentieth century and it turned into an approach as human resources management in the 1980s. It could be observed that many organizations, which deem the human as the most critical stakeholder, adopt a traditional way of personnel management in operating human resources. The employees play a key role in the success of an organization. For this reason, subjects such as recruitment, training, development, career management, performance appraisal, occupational health, and safety are the fundamental functions of human resources management. The study examines to what extent these roles are evaluated through a case study. The subject matter of the study is the most powerful culture and art foundation in Turkey. Compared to many other nonprofit organizations, the foundation actively performs a variety of services within a year worldwide. The fact that the total number of employees might rise up to 800, including the field personnel, indicates the need of a good functioning human resources management. The human resources practices of the foundation are examined and evaluated within that scope.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Beste Gökçe Parsehyan",authors:[{id:"189113",title:"Dr.",name:"Beste",middleName:null,surname:"Gokce Parsehyan",slug:"beste-gokce-parsehyan",fullName:"Beste Gokce Parsehyan"}]},{id:"59152",title:"Marketing Strategies for the Social Good",slug:"marketing-strategies-for-the-social-good",totalDownloads:1594,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Social network sites (SNS) have proven to be a good environment to promote and sell goods and services, but marketing is more than creating commercial strategies. Social marketing strategies can also be used to promote behavioral change and help individuals transform their lives, achieve well-being, and adopt prosocial behaviors. In this chapter, we seek to analyze with a netnographic study, how SNS are being employed by nonprofits and nongovernment organizations (NGOs) to enable citizens and consumers to participate in different programs and activities that promote social transformation and well-being. A particular interest is to identify how organizations are using behavioral economic tactics to nudge individuals and motivate them to engage in prosocial actions. By providing an understanding on how SNS can provide an adequate environment for the design of social marketing strategies, we believe our work has practical implications both for academicians and marketers who want to contribute in the transformation of consumer behavior and the achievement of well-being and social change.",book:{id:"6583",slug:"marketing",title:"Marketing",fullTitle:"Marketing"},signatures:"Alicia De La Pena",authors:[{id:"196878",title:"Dr.",name:"Alicia",middleName:null,surname:"De La Pena",slug:"alicia-de-la-pena",fullName:"Alicia De La Pena"}]}],onlineFirstChaptersFilter:{topicId:"4",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82382",title:"A Cultural Approach in the Synchronous Class in English Teaching and Learning",slug:"a-cultural-approach-in-the-synchronous-class-in-english-teaching-and-learning",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105553",abstract:"If culture is defined as a way of training to obtain knowledge through educational channels, the concept is associated with educability. Therefore, teaching cognitive, attitudinal, and procedural knowledge directly indicates teaching and learning culture to acquire norms and patterns of sociocultural behavior. The purpose of this study was: to debate about the way interaction among students and teachers in synchronous classes based on life’s materials, topics, and methods, and critical or reflective thinking can be adapted by the teacher to the students’ closest environment to communicate in English as an international language. If a language is taught, spoken, and learned in the country, culture surrounding the context is taught. If this language is not spoken in the place, the knowledge system also transmits norms and values, different from those of the language. So, the students get, culturally and socially, modes of action, principles, and knowledge through international language learning. Thus, teaching and learning English as an international language means the way possible interaction has opportunities for every student’s growth and the way their personality formation gets integral results. English taught and learned as an international language denotes reaching the students’ world and needs to communicate in English as a meaningful international language.",book:{id:"10662",title:"Pedagogy - Challenges, Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10662.jpg"},signatures:"Ned Vito Quevedo Arnaiz, Nemis García Arias and Fredy Pablo Cañizares Galarza"},{id:"82470",title:"The Effect of COVID-19 on the Quality of Life of Care Workers: Challenges for Social Services Leaders",slug:"the-effect-of-covid-19-on-the-quality-of-life-of-care-workers-challenges-for-social-services-leaders",totalDownloads:1,totalDimensionsCites:null,doi:"10.5772/intechopen.105603",abstract:"Stressful situations are likely to impact health and social care workers’ quality of life negatively. Indeed, mental, physical, and emotional health problems have been reported in relation to the effects of the COVID-19 pandemic on the quality of life of health care workers. Instead of health care workers’ reality, and despite the care sector’s relevance, studies of the effects of COVID-19 on the quality of life of care workers have not been sufficiently explored. Recognizing the effect of COVID on the quality of life of care workers will collaborate with leaders of organizations, social work practitioners, and academics in the design of policies that promote better working conditions. Therefore, during 2021, a study was carried out in Chile where 150 social services and care workers were surveyed in Chile using a version of COV19-QoL in Spanish. The impact of COVID on quality of life is described, and the challenges that this reality implies to social service leaders are presented.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Magdalena Calderón-Orellana, Alejandra Inostroza and Paula Miranda Sánchez"},{id:"82448",title:"Virus World Vulnerability: A Critical Reading of Gender and Performance in Bo Burnham’s “Inside” (2021)",slug:"virus-world-vulnerability-a-critical-reading-of-gender-and-performance-in-bo-burnham-s-inside-2021",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105182",abstract:"Through an engagement with the seminal work of Raewyn Connell on masculinities and hegemonic masculinity, this chapter argues for the hegemonic norm as producing behaviour among men that can be traced in multiple male subjectivities. The argument is that men respond to the prevailing masculine norm by enacting self-protective disavowal—a complex psychological process that involves the reordering of reality in the interests of the maintenance of power, and one that is seen in cases of both legitimate and imagined threats to the self and the body. Self-protective disavowal is at the core of the Same Shit phenomenon—the idea that while the experience of masculinity varies across culture and position in the gender order, self-protective disavowal is a constant that leads to predicable patterns among men. The discussion then explores deliberate vulnerability as a kind of anti-protective disavowal in Bo Burnham’s INSIDE, a complex, undefinable ‘special’ released on Netflix in 2021. The chapter considers Burnham’s work as a departure from self-protective disavowal and Same Shit masculinity through deliberate vulnerability and critically evaluates the value of this alternative, especially given the nihilism that reigns over the work and calls into question the validity of uncritically romanticization of alternatives.",book:{id:"10540",title:"Masculinity Studies - An Interdisciplinary Approach",coverURL:"https://cdn.intechopen.com/books/images_new/10540.jpg"},signatures:"Chris McWade"},{id:"82454",title:"Prospects and Pitfalls Experienced by Social Workers Working in a Confounding Environment in a South African Setting",slug:"prospects-and-pitfalls-experienced-by-social-workers-working-in-a-confounding-environment-in-a-south",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105604",abstract:"While social workers are professionally and aptly placed to facilitate a turn-around environment rife with a conglomeration of challenges such as poverty, ignorance, and diseases, the chapter discusses the developmental prospects and pitfalls that confound their practice in South Africa. Opportunely, social work interventions continue to gain developmental mileage through increased training of social workers, their increased deployment in various versatile domains of social and economic development and increased widening of the scope of social work research, especially current research in fields such as HIV/AIDS and coronavirus. On the other side of the coin, the chapter discusses social work pitfalls attributed to professional curricular gaps as social work continue to follow a western-centric curriculum; the presence of various metaphysical beliefs and myths that weaken or derail social work interventions and a weaker research environment to offer a plausible and timely solution to the prevalent problems. The chapter concludes by calling for a paradigm shift in the social work curriculum as well as its indigenization to productively respond to the South African socio-cultural and geographical milieu.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Simon Murote Kang’ethe"},{id:"82425",title:"Financial Reporting and Analysis of Tesla Green Technology in the United States Market",slug:"financial-reporting-and-analysis-of-tesla-green-technology-in-the-united-states-market",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105065",abstract:"This study aims to discuss and analyze the financial position and performance of the US Tesla green technology company in the United States. This study uses a case study approach, financial data, and website methodologies to collect and analyze the research data. The case study is Tesla, Inc., which is a US electric vehicle and clean energy company based in Austin, Texas. Tesla is a green technology company that produces and designs electric cars, battery energy storage from home to grid-scale, solar roof tiles and solar panels, and related products and services. Tesla is growing fastly by introducing new green products, and it is now one of the world’s most valuable enterprises. It has a high market capitalization of almost US$1 trillion to become the world’s most valuable automaker. This study concludes that Tesla has changed their strategy to become the most worldwide sales of purely battery electric vehicles, capturing 23% of the market and 16% of the plug-in electric battery in the market for 2020. It has also developed a significant installer of photovoltaic systems through its subsidiary Tesla Energy in the United States. One of the largest global battery energy-storage systems suppliers is Tesla Energy, with 3.99 gigawatt-hours installed in 2021.",book:{id:"11251",title:"Banking and Accounting",coverURL:"https://cdn.intechopen.com/books/images_new/11251.jpg"},signatures:"Nizar Mohammad Alsharari"},{id:"82427",title:"Our Globalization Era among Success, Obstacles and Doubts",slug:"our-globalization-era-among-success-obstacles-and-doubts",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105545",abstract:"In the last decades, the never-ending and unlimited expanding of both international economies and operations became globalization. Among its main features, one could recall the enormous increase of world macro-economic quantities (Gross World Product, Inter-continental Trade, FDI), as well as financial values (public debts and currency printing). The chapter tries to quantify them, by a statistical analysis of historical data (Section 1). Section 2 is dedicated to the strategic problems of firms, in particular the threats and opportunities for (inter) national firms willing to become global, and obstacles are included in Section 3. This given, it deals with the behavior of countries from the political and juridical points of view, and those ones passed form initial perplexities, distaste, or even hostility to a favorable behavior. Conclusions (Section 4) recall both the problematic alternative for globalized companies between “the world as our next door” and their social responsibilities and the similar problem for host countries, between socioeconomic advantages and protection of local workers, resources, and environment.",book:{id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg"},signatures:"Arnaldo Canziani, Annalisa Baldissera and Ahmad Kahwaji"}],onlineFirstChaptersTotal:282},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:28,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},overviewPagePublishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}]},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11478",title:"Recent Advances in the Study of Dyslexia",coverURL:"https://cdn.intechopen.com/books/images_new/11478.jpg",hash:"26764a18c6b776698823e0e1c3022d2f",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 30th 2022",isOpenForSubmission:!0,editors:[{id:"294281",title:"Prof.",name:"Jonathan",surname:"Glazzard",slug:"jonathan-glazzard",fullName:"Jonathan Glazzard"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. Agogbua, Eberechi R. Keyagha and Itorobong I. Nkanga",slug:"carotenoids-in-cassava-manihot-esculenta-crantz",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. Heshmati",slug:"comparative-senescence-and-lifespan",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hassan M.",surname:"Heshmati"}],book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81576",title:"Carotenoids in Thermal Adaptation of Plants and Animals",doi:"10.5772/intechopen.104537",signatures:"Ivan M. Petyaev",slug:"carotenoids-in-thermal-adaptation-of-plants-and-animals",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Ivan",surname:"Petyaev"}],book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81358",title:"New Insights on Carotenoid Production by Gordonia alkanivorans Strain 1B",doi:"10.5772/intechopen.103919",signatures:"Tiago P. Silva, Susana M. Paixão, Ana S. Fernandes, José C. Roseiro and Luís Alves",slug:"new-insights-on-carotenoid-production-by-gordonia-alkanivorans-strain-1b",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81298",title:"Roles of Extracellular Vesicles in Cancer Metastasis",doi:"10.5772/intechopen.103798",signatures:"Eman Helmy Thabet",slug:"roles-of-extracellular-vesicles-in-cancer-metastasis",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81290",title:"Musculoskeletal Abnormalities Caused by Cystic Fibrosis",doi:"10.5772/intechopen.104591",signatures:"Mark Lambrechts",slug:"musculoskeletal-abnormalities-caused-by-cystic-fibrosis",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},subseriesFiltersForOFChapters:[{caption:"Plant Physiology",value:13,count:6,group:"subseries"},{caption:"Human Physiology",value:12,count:13,group:"subseries"},{caption:"Cell Physiology",value:11,count:26,group:"subseries"}],publishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},onlineFirstChapters:{paginationCount:7,paginationItems:[{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82270",title:"From Corporate Social Opportunity to Corporate Social Responsibility",doi:"10.5772/intechopen.105445",signatures:"Brian Bolton",slug:"from-corporate-social-opportunity-to-corporate-social-responsibility",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82339",title:"Green Human Resource Management: An Exploratory Study from Moroccan ISO 14001 Certified Companies",doi:"10.5772/intechopen.105565",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"green-human-resource-management-an-exploratory-study-from-moroccan-iso-14001-certified-companies",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82194",title:"CSR and Female Directors: A Review and Future Research Agenda",doi:"10.5772/intechopen.105112",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Sirimon Treepongkaruna",slug:"csr-and-female-directors-a-review-and-future-research-agenda",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[{id:"14",title:"Cell and Molecular Biology",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression"},{id:"15",title:"Chemical Biology",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors"},{id:"17",title:"Metabolism",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation"},{id:"18",title:"Proteomics",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Biochemistry",id:"11"},selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/190409",hash:"",query:{},params:{id:"190409"},fullPath:"/profiles/190409",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()