Technical parameters of the prototypes.
\r\n\t
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Dr. Wei Wu has received awards from many national societies for the originality and quality of his projects. He has authored 70 peer-reviewed papers in international journals.",coeditorOneBiosketch:"A pioneering researcher in obstetrics and holder of three registered patents. Dr. Qiuqin Tang's research interests include genetic and epigenetic risk factors of reproductive and developmental health. She has authored over 20 papers in international journals.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"178661",title:"Dr.",name:"Wei",middleName:null,surname:"Wu",slug:"wei-wu",fullName:"Wei Wu",profilePictureURL:"https://mts.intechopen.com/storage/users/178661/images/system/178661.jpeg",biography:"Dr. Wei Wu is an associate professor and associate department\nchair in the Department of Toxicology, Nanjing Medical University, China, where he received his Ph.D. in Toxicology in 2012.\nHe was a guest researcher at the National Institute of Environmental Health Sciences (NIEHS) between 2017 and 2018. Dr.\nWu is a member of different national and international societies\nin the fields of human reproduction and toxicology and has\nreceived awards from many national societies for the originality and quality of his\nprojects. Dr. Wu has authored seventy-three peer-reviewed papers in international\njournals. He has edited four books and collaborated on ten others as well as seventeen patents and in the organization of three international conferences. He is a\nreviewer for ninety-eight journals.",institutionString:"Nanjing Medical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Nanjing Medical University",institutionURL:null,country:{name:"China"}}}],coeditorOne:{id:"184798",title:"Ms.",name:"Qiuqin",middleName:null,surname:"Tang",slug:"qiuqin-tang",fullName:"Qiuqin Tang",profilePictureURL:"https://mts.intechopen.com/storage/users/184798/images/13334_n.jpg",biography:"Qiuqin Tang is an attending doctor of The Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital). Her research interests include genetic and epigenetic risk factors of reproductive and developmental health. She has authored over 20 papers in international journals such as EBioMedicine, Clinical Epigenetics, Molecular Human Reproduction, Scientific Reports, and European Journal of Endocrinology. She has collaborated in four books and three patents. 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He is also the headmaster of the Family Planning Centre and Gynecological Cytology\nLaboratory at the same university. Dr. Tsikouras is a fellow of the\nInternational Academy of Clinical and Applied Thrombosis/Hemostasis. His scientific activities focus on paediatric and adolescence medicine, gynecological oncology, high-risk pregnancies. He is a reviewer for several international journals and has numerous scientific publications to his credit, including papers and book chapters. 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He\nis currently a professor in the Gynecology and Obstetrics Faculty\nof Medicine, University of Kiel, Germany, and honorary doctor\nat the Democritus University of Thrace, Alexandroupoli University Hospital He previously served as chief of the Department\nof Gynecology and Obstetrics at University Hospital RWTH Aachen,\nGermany. Dr. Rath is a reviewer for numerous journals and chief editor of Geburtshilfe und Frauenheilkunde (GebFra). 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"60712",title:"Techno-Economic Analysis of a Peltier Heating Unit System Integrated into Ventilated Façade",doi:"10.5772/intechopen.76642",slug:"techno-economic-analysis-of-a-peltier-heating-unit-system-integrated-into-ventilated-fa-ade",body:'\nThe thermoelectric generators, sometimes called Peltier modules, are semiconductors based on Peltier effect to pump heat. The advantage of this system is that it can be used in the heating or cooling mode in a simple way. Due to it, the use of the thermoelectric generators is having a growing interest in developing new prototypes in the military, industrial and commercial areas [1, 2, 3, 4, 5].
\nThe studies related to the cooling mode have focused their efforts on developing prototypes [6, 7, 8, 9, 10, 11, 12] that dissipate the heat in small applications such as in lasers, personal computers, refrigerators, cryogenic prototypes, and so on, while heating modes are being applied mainly in architectural area. The essential concepts of Peltier modules applied in the architecture have been introduced by Khire et al. [13], who proposed an ABE system that uses solar energy to compensate for passive heat losses or gains in a building envelope. The authors discussed the design and optimization of Peltier modules with PV panels in their work. Under this context, Xu et al. [14] developed various ABE prototypes in a heating mode, using commercially available PVs and Peltier cells, and Liu et al. [15] designed an ASTRW system with thermoelectric technology and PV panels. Likewise, Vázquez et al. [16] described the basic principles of a new concept for an active thermal wall that improves the current practice for designing and installing air-conditioning for enclosed spaces. Irshad et al. [17] designed a solar TE-AD system that employs thermoelectric modules (TEMs) inside an air duct to provide thermal comfort. In [18], a solar thermoelectric cooled ceiling is combined with a displacement ventilation system. The prototype was tested in cooling and heating modes. Other interesting studies [19, 20] described the application of Peltier cells in active walls, active building windows and thermoelectric ventilators. Recently, Luo et al. [21, 22, 23] proposed a building integrated photovoltaic thermoelectric wall system, which is supported by the co-work of PV module for solar radiation transformation, air gap for thermal dissipation and thermoelectric radiant panel system for active radiant cooling/heating. This study focused on an efficient and accurate system model for the simulation of this system. Wang et al. [24] develop a thermoelectric heating system powered by renewable energy to reduce the CO2 emission in buildings. According to results, the prototype minimises the energy demands and therefore reduces CO2 emissions.
\nThe studies related to the economic analysis of HVAC technologies emphasise energy saving in the heating/cooling system [25, 26, 27] and the energy demand in buildings [28, 29]. From the engineering point of view, the number of Peltier cells, the heat exchanger design and the auxiliary system (fans, back-up system, control system, etc.) are studied in order to reduce the investment, operational and maintenance costs [30, 31, 32]. The purpose of this study is to present the conceptual design of a THU integrated into ventilated façade and analyse its economic viability and its thermal performance. To accomplish this aim, the following items are proposed:
describe the conceptual design and the operating mode of an innovative THU prototype;
compare the thermal performance of a THU prototype with a conventional air-conditioning system using the typical economic indicators (investment costs, maintenance costs and operational costs).
This work contributes in identifying the key aspect that may increase the efficiency of the HVAC systems in ventilated façades. Also, this research completes the authors’ previous work [33, 34, 35, 36, 37] about the theoretical design and construction of an active ventilated façade with Peltier modules. The authors are aware that a techno-economic analysis of a THU prototype has not yet been reported.
\nSince 2009, the authors have been working on alternative HVAC systems for buildings. Based on their previous experience as architects (not engineers) in the area of building services and energy systems [38], the authors have focused on the design of decentralised ventilated heating system for new and rehabilitated building envelopes. The result was the construction of a simplified inhabited housing unit (prefabricated module) with a thermoelectric heating system. A detailed report on this first THU version (v1.1) and its manufacture has been presented by the authors in previous works [33, 34, 35, 36]. This section provides a brief description of this first version and presents the improvement of this prototype (THU v1.2). Both prototypes were installed in a prefabricated test room to analyse their performance under real conditions.
\nThermoelectric heating unit (THU v1.1) consists of three subsystems: a heating system, a ventilation system and a control system. The heating system was composed of 84 RC12–8 Peltier modules (Marlow Industries, Inc.) with a heat dissipation system. The Peltier modules were placed in groups of two thermoelectric modules, where the Peltier modules were connected in series and the groups were connected in parallel; altogether, they form 42 groups that require a voltage of 50 volts and have a heating capacity of 3 kW (3/4TR heating tonnage). The elements of heat dissipation system are composed of 84 heat pipes, 21 finned heat sinks, two axial fans (fixed on the façade) and two tangential fans (fixed on the internal chamber). A schematic diagram of THU v1.1 prototype is illustrated in Figure 1.
\nSchematic diagram of THU v1.1: (a) parts of the prototype, (b) heating system (heat pipes with Peltier cells) and (c) external view showing the electrical connection (down) and the ventilation grills (sideways).
The prototype has a control system that supplies electric energy to the system, controls the auxiliary equipment (fans, sensors, actuators, etc.) and regulates the working operations (inside temperature). In addition, a protection equipment was included in case of accidents that basically consists of a PLC, sensors and actuators.
\nRecently, an improved prototype of the THU v1.1 was designed, named THU v1.2. This second version mainly consists of three subsystems: a heating system, a ventilation system and a control system. The heating system is composed of 20 Peltier modules (Marlow Industries, Inc.) with a heat dissipation system. All Peltier modules are connected in parallel, require a voltage of 20 volts and have a heating capacity of 1 kW (1/4TR heating tonnage). The elements of heat dissipation system are composed of 20 finned heat sinks and four tangential fans. This second version has more insulation, better heat dissipation and lower power consumption. Figure 2 shows the outside and inside views of THU v1.2 prototype.
\nIntegration of the thermoelectric system in THU v1.2: (a) top view, (b) inside view (air inlet and outlet and ceramic surface) and (c) outside view of the prototype with the grills to dissipate the heated/cooled air.
In order to know the economical and thermal viability of the THU v1.2 prototype, an identical test room was built for a conventional air-conditioning system, as shown in Figure 3. The conventional air-conditioning system uses inverter technology to regulate the voltage, current and frequency of an air conditioner so that it consumes only the necessary energy. The used model in this work is the air-conditioning split (1X1 MSZ-HJ35VA Mitsubishi Split) with a heating capacity of 3.6 kW (1TR heating tonnage).
\nSchematic diagram of conventional system v2.0: (a) top view, (b) inside view and (c) outside view.
To provide a consistent baseline for comparative analysis, the authors show the technical information for the THU prototype and conventional air-conditioning system (Table 1).
\nParameter/component | \nTHU v1.0 | \nTHU v1.2 | \nConventional system V2.0 | \n
---|---|---|---|
Internal dimension (m) | \n4.0 \n | \n3.75 \n | \n3.75 \n | \n
Façade thickness (mm) | \n35 | \n160 | \n160 | \n
Dimension of chambers (cm) | \n100 × 10 | \n100 × 10 | \nNo | \n
U of the façade (\n | \n0.52 | \n0.21 | \n2.21 | \n
Double height | \nNo | \nYes | \nYes | \n
Roof thickness (mm) | \n35 | \n127 | \n127 | \n
U of the roof (\n | \n0.52 | \n0.21 | \n0.21 | \n
Floor thickness (mm) | \n19 | \n195 | \n195 | \n
U of the floor (\n | \n5.26 | \n0.29 | \n0.29 | \n
Technical parameters of the prototypes.
The exterior image in this project is based on an opaque ventilated façade with an active mechanism (air grilles) that adapts to different environmental conditions and seeks maximum efficiency at all times. The activation mechanism adjusts the air chamber ventilation of the façade and the heating system. This means that during winter months, the grilles are shut to enhance the accumulation of heat inside a room. However, in the summer months, the grilles are opened to extract the excess heat from the system. It is relevant to mention that the initial configuration of the active ventilated façade is in accordance with the requirements under the regulation of the ventilation of the cavity of the ventilated façade. As is shown in Table 2, an enclosure of a light sheet metal, as a light element with low thermal inertia that allows an immediate response to external environmental conditions and a ventilation capacity of 50CFM in the room was selected.
\nMaterial | \nThicknesses (mm) | \nΛ (W/mK) | \nR (m2K/W) | \n
---|---|---|---|
Sheet metal | \n0.8 | \n— | \n— | \n
Ventilated air chamber/sealed | \n100 | \n— | \n0.18 | \n
Inner sheet | \n177.5 | \n0.163 | \n4.62 | \n
Semi-rigid rockwool panel | \n80 | \n0.034 | \n1.91 | \n
Sandwich panel | \n35 | \n0.028 | \n1.25 | \n
Rockwool panel | \n50 | \n0.035 | \n1.40 | \n
Plasterboard | \n12.5 | \n0.25 | \n0.05 | \n
Technical parameters of the active ventilated façade THU v1.2.
The internal concept of the THU prototype consists of three layers, two air chamber and a HVAC system (thermoelectric system), as is shown in Figure 4. The first layer (external view) is composed of the metallic frame with two fans and a heat dissipation system. The fans allow the entrance of air to the external chamber (chamber connected to the outside environment), it passes through of the heat pipes and leaves external chamber eliminating the excess heat from the thermoelectric system. A relevant detail in the external view is that for THU v1.1, two axial fans were used, which were placed on the façade, while the second version THU v1.2 used two tangential fans, which were fixed in the lower part of the external chamber. This difference improves aesthetics and heat dissipation in the thermoelectric system.
\nSchematic diagram of the design: (a) THU v1.1 prototype and (b) THU v1.2 prototype.
The thermoelectric system is fixed in the second layer and its function is to separate the two chambers and supply heat to the room. Finally, the third layer connects the internal chamber with the room. This is composed of a group of heat sinks and two tangential fans (fixed in the lower part of the internal chamber). They allow the passage of air into the inner chamber for supplying hot air in the room. In this model, an air exit grill on the top of the wall was placed for extracting the cold air of the room.
\nThe Peltier modules consist of two or more elements of n-type- and p-type-doped semiconductor material that are electrically connected in series and thermally connected in parallel. These thermoelectric elements and their electrical interconnects are typically mounted between two ceramic substrates. Applying a voltage to a thermoelectric module creates a temperature difference. This temperature difference can be used to transfer heat from a cold side to a hot side and vice versa. Therefore, Peltier modules can be used to control the climate in rooms: to heat in winter and to cool in summer. In this regard, it is necessary to obtain a better heat transfer between the Peltier cells and the room air for increasing the heat transfer area of the ceramic plates with heat sinks [39, 40]. In this section, a brief overview of the basic equations that influence the functioning of a THU system is presented. The equations that mainly govern the thermoelectric effect are the electric power and the heat flow. The electric power shows the difference between the heat dissipated on the hot side and the heat absorbed at the cold side of the Peltier modules, and this is given by
\nwhere \n
The heat flow is given by
\nand
\nwhere \n
A key parameter used to measure the performance of any air-conditioning system is the COP, defined as the useful thermal power output per unit of heat power. Its mathematical expression can be given as follows [42]:
\nThe air-conditioned systems can be used in heating and cooling modes. In this work, the heating cycle is only considered, so the COP in heating mode for conventional system is given by [43]
\nwhere \n
In the case of thermoelectric system, the ideal COP in the heating mode is given by [43]
\nwhere \n
The economic evaluation is based on investment costs, operational costs and maintenance costs. The investment costs consider the cost of each piece of the prototype, including the electrical equipment, structure, heating system and instrumentation equipment and electrical installation. For the determination of the investment costs, these costs were divided into three categories: engineering costs, supply/handing cost and auxiliary costs. The engineering costs combine design, manufacturing processes, modelling of the pieces, architectural plans and installations. The supply/handing costs involve the material supply. In this case, the prices are quoted for Pamplona, Spain. Finally, the auxiliary costs depend on the finishing touches of the project.
\nOperational costs refer to the costs for the proper operation of each prototype. These costs mainly depend on the electrical consumption of the prototype subsystems (cooling–heating system, ventilation and control system). The THU v1.2 prototype under investigation was designed with a power nominal consumption of 1 kW, while that the conventional air-conditioning system is of 1.04 kW.
\nMaintenance costs consider all types of activities related to the repair and replacement of damaged pieces in the prototype subsystems. These costs have been estimated based on the price of the prototype and the maintenance of each subsystem. In the case of the conventional v2.0 system (Split 1x1MSZ-HJ35VA Mitsubishi), these costs are related to the use of special chemicals, checking the pressure, voltage drop, amperage drop, cleaning and blowing the dirty parts. According to [40], the maintenance cost of this system varies from $737 to $2156 Euros each year, depending on the capacity of cooling/heating. It represents between 10 and 20% of the total investment cost of the Split cost. In the case of THU v1.2, the authors have estimated that the maintenance cost could be approximately 6–10% of the heating system cost. This estimation was based on 1.5 years of test with the prototype [36].
\nThe lifetime of the prototypes reflects the useful life of each system or the prototypes during a determined time. It includes the operational, physical and technological lifetime. In this study, the operational lifetime of thermoelectric device reported by Marlow Industries. Inc. [41] is in the range of 20,000–350,000 h at normal conditions, and Mitsubishi Company guarantees 15 years for inverter air-conditioning [44]. It is estimated that the physical lifetime of the structure is 30–40 years because the structural design combines durability, resistance and anti-corrosive materials. Also, it is assumed that the technological lifetime of the THU system is as long as the lifespan of the building (30–40 years), since it has a digital display that allows controlling the Peltier system and a sophisticated PLC that can be reprogrammed to the user necessities.
\nIn addition to an economic assessment, the THU systems have social benefits that play an important role in taking care of the environment. In other words, the benefits associated with the use of THU systems are mainly related to reducing carbon dioxide emission. THU systems do not emit CO2 in the operational and maintenance phase as inverter air-conditioning systems, because they do not have a working fluid. Therefore, THU systems are a good option for avoiding greenhouse gas emissions. Their electronic components can also be recycled. Moreover, a photovoltaic system could be added into this system to generate electricity and could reduce the annual operational costs, according to [14, 15].
\nThe investment costs of the THU v1.2 prototype and conventional air-conditioning system are reported in Table 3. The results show that the overall cost of this protect was approximately 84,860 Euros. This cost is because the authors considered the architectural and engineering aspects of both prototypes. Also, it can be observed that the highest value was for the engineering costs at 69.27% of the total investment cost, so that it is suggested that the designer has to pay attention for proposing competitive and viable prototypes.
\nDescription | \nCosts (€) | \n
---|---|
-Construction of sills, general electricity networks, water and fibre optic installation | \n18,115.38 | \n
-Gardening work | \n|
-Manufacture of the heat exchange module based on the Peltier cells | \n38,829.71 | \n
-Design, installation and start-up of equipment for measurement and control | \n|
-Supply of the materials for the manufacture of the outside coating façade and the finishes of the test modules | \n2523.90 | \n
-Supply of insulation: blankets and insulation plates allocated to cover façades, roofs and floors (inside and outside) | \n2381.40 | \n
-Supply of materials for the interior walls and flooring of the modules: substructures and plasterboard plate | \n1095.96 | \n
-Transfer of Rockwool materials | \n|
-Supply of four motorised doors to control the ventilated camera | \n632.80 | \n
-Supply and assembly of structures and enclosures | \n5993.00 | \n
-Split 1x1MSZ-HJ35VA 3.15 W cool-3.5 W heat MITSUBISHI and miscellaneous accessories | \n1332.07 | \n
-Installing the insulation (inside and outside) and coating the walls and floors with plasterboards | \n1769.68 | \n
-Placing metallic elements on the façades | \n10,829.71 | \n
-Constructing and installing the stairs | \n|
-Painting | \n513.60 | \n
-Installing the Split 1x1MSZ-HJ35VA | \n860.53 | \n
Investment costs of the prototypes v2.0 and conventional air-conditioning system.
The improvements of THU v1.1 prototype reduced the total investment cost by 30%. This percentage is directed directly related to the design, manufacture process and size of the prototype. On the other hand, Table 3 shows that the supply/handing cost represented no more than 18.89% of the investment cost and that the auxiliary cost contributed only 14.54%, as it was expected. The above data indicate that the design plays an important role in engineering aspects. This means that the designer should select appropriate construction materials, the number of Peltier cells and the distribution of each system considering their cost. Also, the results indicate that the conventional v2.0 system is more economically viable than THU v1.2 because the THU system is the first product built in a prefabricated module. This prototype would be more viable if a considerable number of THU systems were manufactured.
\nConcerning manufacturing process of heating system, it was noted that investment costs are directly influenced by the size and number of Peltier modules, that is, an increase of Peltier modules increases the number of finned heat sinks, so that the investment costs increase. Also, the use of heat pipe sinks increases the investment costs by 30%. Although the heat pipe sinks offer better performance in terms of heat dissipation, the manufacturing process of a finned heat sink is less complicated than that of a heat pipe sink, so that the finned heat sink is more economic. Moreover, it was seen that an increase in insulation level is beneficial in reducing heating demand. In the supply cost can be see that represent no more that 16% of the investment costs. According to the authors’ experiences, these costs can be increased or reduced depending on the location of the supplier. Also, Table 3 shows that the conventional air-conditioning system is more economically viable than THU v1.2, due to the manufacturing cost.
\nIn regard to the operational costs, two 24-h thermal performance tests in January, from 13:30 to 13:30 h, were carried out in both prototypes, see Figures 5 and 6. Firstly, it was noted that after 30 min, the internal temperature of the room in the THU v1.2 reached 21°C, while in conventional system it was 26°C. In both tests, it was observed that there was a difference of 5°C in the internal temperature of the room. This means that THU v1.2 prototype could not reach 26°C in the room. It is because the THU v1.2 prototype was designed with 1/4TR of heating tonnage and conventional v2.0 system is about 1TR of heating tonnage. To increase the temperature in the room, an increase of Peltier modules is needed. Therefore, it was deduced that the number of Peltier modules have an important impact on the thermal performance of the prototype.
\nThe inside temperature of the room in THU v1.2 and conventional v2.0 system, from January 12 (13:30 h) to 13 (13:30 h) in Pamplona, Spain.
The inside temperature of the room in THU v1.2 and conventional v2.0 system, from January 13 (13:30 h) to 14 (13:30 h) in Pamplona, Spain.
The results showed that THU v1.2 had a more stable thermal behaviour than the conventional air-conditioning system, despite variation in the outside temperature, see Figures 7 and 8. It can be claimed that the active mechanism may be a key parameter in the efficiency.
\nThe variations of solar radiation, wind speed and outside temperature from January 12 (13:30 h) to 13 (13:30 h) in Pamplona, Spain.
The variations of solar radiation, wind speed and outside temperature from January 13 (13:30 h) to 14 (13:30 h) in Pamplona, Spain.
The conducted tests showed that the nominal consumption of the Peltier equipment, with a set point of 22°C, is approximately 0.45 kW, while the conventional v2.0 system has a consumption of 0.15 kW, with a set point of 26°C. This affirms that the THU v1.2 design should improve the physical model of THU v1.2 prototype, and the annual maintenance cost is between 6 and 10% of the total investment cost of the system. Compared with the conventional air-conditioning system, THU v1.2 prototype is more economically viable in maintenance, so that the conventional air-conditioning system frequently needs maintenance and the replacement of parts.
\nThe indicator associated with COP heat of the conventional air-conditioning system showed that it is in a range of 2.6–3, while the THU v1.2 prototype is between 0.46 and 1.07, as is illustrated in Figure 9. Considering the annual experimental data, the COP Carnot in a heating mode for THU v1.2 prototype is between 5 and 18%. Comparing the results of [43], it could be deduced that the conventional air-conditioning system has a COP of 30%. Thus, it can be noted that the conventional air-conditioning system is more efficient than the THU v1.2 prototype.
\nExperimental measurement COP of THU v1.2 prototype versus the months.
Moreover, other tests have been published in [45, 46], where it is seen that the power consumption has higher values in Peltier systems, which is associated with the behaviour of Peltier in relation with the weather. As shown in Figure 10, the THU version 1.1 system consumes approximately 1.2 kW of power, while the THU version 1.2 system consumes approximately 1 kW. Therefore, the THU version 1.2 THU system has a great economic advantage on the THU version 1.1 prototype.
\nGraphic of the TCHU v1.1 with 12 V in heating.
In summary, the techno-economic analysis gives rise to several interesting ideas for future research, such as the inclusion of photovoltaic panels and batteries in the prototypes, which will create an autonomous and efficient system.
\nThe goal of this study was to describe the conceptual design and the operating mode of an innovative thermoelectric heating unit (THU) prototype and compare the thermal performance of a THU prototype with a conventional air-conditioning system. The analysis of investment costs, maintenance costs and operational costs was used as a reference point in the comparison. We found that the overall cost of this project was approximately 84,860 Euros.
\nBy focusing on the investment costs of the THU system, the results reveal that THU v1.2 prototype design is 30% more economical than THU v1.1 design, due to a better design strategy in the manufacture process and the dissipation systems. By considering only dissipation systems, it was noted that the use of heat pipe sinks increase by 30% the investment costs. Although the heat pipe sinks offer better performance in terms of heat dissipation, the manufacturing process of a finned heat sink is less complicated than that of a heat pipe sink, so that the finned heat sink system is more economic.
\nFrom a comparative point of view, the results show that the conventional air-conditioning system is economically viable than a THU system; therefore, if THU was to enter the market, it is necessary to implement a strategy that reduces costs. Regarding the thermal performance, the results demonstrate that THU v1.2 had a more stable thermal behaviour than the conventional air-conditioning system. The maintenance costs indicated that THU v1.2 prototype is more economically viable in maintenance than the conventional air-conditioning system. Moreover, verifying the environmental benefits between the studied systems, it was found that the maintenance of a conventional air-conditioning system has a greater environmental impact than the THU v1.2 system. The authors recommended a life cycle analysis (LCA) of both prototypes, in order to know the pros and cons of the environment.
\nThe authors acknowledge financial support from Conacyt (México), PRODEP, Universidad de Navarra Project no. 1804805, Ministerio de Ciencia e Innovación del Gobierno de España BIA2013-46463-R, Asociación de Amigos de la Universidad de Navarra, Aislamientos San Fermin, Berotza, Jacar, Rock wool, Teczone, Trox.
\nThere is no conflict of interest.
ABE | active building envelope |
ASTRW | active solar thermoelectric radiant wall |
CFM | cubic foot per minute |
COP | coefficient of performance |
HVAC | heating ventilating and air conditioning |
I | load current \n\n\nA\n\n\n |
K | total thermal conductance \n\n\n\nW\n/\nK\n\n\n\n |
l | length of the semiconductors (m2) |
m | number of Peltier cells |
PLC | programmable logic controller |
PV | photovoltaic |
q | heat dissipated |
R | resistance (Ω) |
S | cross-sectional area of semiconductor arms (m) |
TE-AD | thermoelectric air duct |
TEM | thermoelectric modules |
THU | thermoelectric heating unit |
TR | refrigeration tons |
V | voltage |
V1.1 | version 1.1 |
v1.2 | version 1.2 |
Greek letters | |
\n\n\nα\n\n\n | total Seebeck coefficient |
\n\n\nκ\n\n\n | thermal conductivity of the semiconductor materials |
\n\n\nρ\n\n\n | electrical resistivity |
Subscripts | |
a | ambient |
c | cold side |
cond | conductivity |
eva | evaporator |
H | hot side |
n | n-type semiconductors |
p | p-type semiconductors |
Anemia is rising in importance as a biomedical research priority and a public health issue in the old age group. World health organization (WHO) has defined anemia as hemoglobin concentration (Hb %) below 12 g/dL in women and below 13 g/dL in men [1]. Hb declines slightly with more advancing age with frequency of anemia being more pronounced in men. The geriatric anemia is related with mortality and inferior health associated quality of life [2, 3]. This is important area to be explored as there is little literature that explains the association of anemia with old age and lesser research has led anemia to go undiagnosed and untreated. In the shade of absent obvious ailment, complaints of generalized weakness left ignored [4, 5, 6, 7, 8, 9]. The incidence of anemia increases comorbidities resulting in increased frequency of hospitalizations hence leading on to adverse impact on survival [10, 11]. So a better outlook is needed to define the optimal Hb levels and to diagnose out the cause of anemia in old age group [12, 13].
The definition of anemia in the elderly in the literature is controversial. The WHO criteria were established in the 1960s in a cohort lacking individuals >65 years of age [14]. According to WHO criteria anemia was defined as hemoglobin <12 g/dL in women and <13 g/dL in men and absolute iron deficiency was defined as a serum ferritin <30 ng/mL [15, 16]. The National Health and Nutrition Examination Survey III classifies anemia into four categories as per underlying cause such as anemia from nutritional deficiency, anemia due to renal diseases, anemia of chronic disease and unexplained anemia, in the absence of other specific causes. Worldwide both the number and ratio of older adults growing and there are nearly 500 million (7%) adults, 65 years and older in the world and by 2030 will double to 1 billion (12%). It was predicted that 164 million elderly people who constitute 23.9% of geriatric population were suffering from anemia globally and death risk was elevated to 49% [3, 17]. As per a systematic review the prevalence of anemia was found to be 3–50%. Out of that 3–25% constituted from community-based studies, 31–50% from nursing homes studies and 40–72% hospital admissions [18]. The prevalence of anemia in the institutional studies was observed to be 24%, 31.4%, 46.8%, 54.5%, 66.3%, 67% and 74% in Belgium, Israel, Pakistan, Ethiopia, German, China and US Arespectively [1, 19, 20, 21, 22, 23]. Whereas the prevalence of anemia was observed to be 7.3%, 17.7%, 19% and 38% in Turkey, rural India, Iran and urban India respectively in population-based studies [24, 25, 26, 27].
In elderly, anemia is ignored frequently in spite of obvious evidence that due to decreased Hb levels physiologic functions may worsen in the patients [28]. It has been noticed that there are 75% chances of negligence of symptoms by the patients [29, 30]. Also no related positive finding could be recognized on general physical examinations as there are insufficient signs on physical examination that are specific for mild to moderate anemia [3, 31, 32]. However signs and symptoms vary from weakness, irritability, alopecia, xerostomia and depression especially in iron deficiency anemia (IDA). The restless leg syndrome seen in elderly is also commonly take place with iron deficiency [33, 34, 35]. Many studies searched in literature verified that anemia is an independent risk factor for rise in morbidity and mortality along with decreased quality of life in older persons [18, 28, 36, 37, 38].
Geriatric anemia to a certain extent may be due to unrevealed underlying diseases or due to reduced bone marrow functional reserve or adaptation to reduced lean body mass with diminished oxygen requirements or escaped erythropoietin secretions. There is plenty of substantiation that hematopoietic stem cells undergo some qualitative changes with age hence resulting in reduced proliferative and regenerative capacity. It has been realized that anemia at older age is rising with the possibly of changes in diagnostics and demographics. Though this also have been emphasized by authors that anemia in the elderly do has a treatable cause [18, 39, 40]. The etiopathogenesis of anemia in geriatric age group is multifaceted and varying from nutritional deficiencies to inflammatory progressions resulting in immunodeficiency. Other causes may be from bone marrow failure syndromes to chronic kidney disease. In general causes of anemia were found to be anemia of chronic disease (ACD) associated with co morbidities, deficiency anemia constituting iron deficiency, vit B 12 deficiency, folate deficiency and others and unexplained anemia. While considering the underlying diseases, anemia in elderly is also seen associated with
As per National Health and Nutrition Examination Survey III anemia has been classified into four categories as per underlying cause such as anemia from nutritional deficiency, anemia due to renal diseases, anemia of chronic disease and unexplained anemia, in the absence of other specific causes.
Anemia of chronic disease (ACD) is found to be the most common cause of anemia. The prevalence of ACD varies from 33.1–77% in elderly patients (Table 1) [1, 37, 48].
Prevalence | Author’s name, year |
---|---|
35% | Joosten E et al., 1992 [1] |
65.6% | Chernetsky A et al., 2002 [19] |
64% | Willems JM et al., 2012 [49] |
77% | Joosten E et al., 2014 [48] |
46% | Gowanlock Z et al., 2016 [50] |
33.1% | Michalak SS et al., 2018 [37] |
Prevalence of anemia of chronic disease in geriatric age group.
The cause of ACD in hospitalized elderly patients is mostly the consequence of added chronic underlying diseases and also is an indicator of several reactive and clonal conditions.3 Many underlying diseases, like H pylori, renal impairment, congestive heart failure, myelodysplastic syndrome (MDS) is seen associated with ACD in elderly [19, 42, 51]. Although concentrations of serum ferritin, white blood counts (WBC) and C-reactive protein (CRP) levels in ACD patients remains high in ACD but high Hepcidin (H) level occurring due to inflammation facilitates development of ACD in elderly patients. Wang WJ et al. have emphasized that best threshold value for the diagnosis of ACD is 130.05 μg/L with the sensitivity of 72% and the specificity of 96% [51, 52, 53]. An analysis done by López-Sierra Metal also favored use of serum Transferrin Receptor (sTfR) to check out the state of erythropoiesis in patients with chronic disease [54].
Nutritional deficiency anemia is an important clinical problem with prevalence varying from 4% to 22.5% in older patients associated with caloric and protein restriction, iron, vitamin B12, folic deficiency [19, 37, 48, 55]. Protein and energy malnutrition cause an increase in the production of cytokine, stimulation of inflammationand anemia. Due to decreased macrophages activity and ineffective erythropoiesis, reduced red cell mass is seen. In addition, increased cytokines and hepcidin serum levels also seen associated with obesity and underweight [56]. Anemia patients with protein and energy malnutrition more frequently suffered from hypoalbunemia [43]. Absolute IDA is well-defined as anemia with absence of total body iron. To diagnose IDA although serum ferritin is the most often used parameter, but with older age and in the presence of inflammatory diseases concentration of serum ferritin increases and losses its significancy.10Iron deficiency anemia (IDA) contributes approximately 13–15% of total anemia of geriatric age group, mainly associated with underlying diseases.Evidence has been supported by improvement of IDAfrom iron rich diet in geriatric patients [1, 37, 48, 55, 57, 58, 59]. New insights into iron homeostasis lead to new diagnostic assays such as serum baseline hepcidin levels could be a useful tool to identify ID in anemic elderly patients. Wang WJ et al. have highlighted thatthe best threshold in diagnosis of IDA was 93.31 μg/L with the sensitivity of 88% and the specificity of 89% [53, 54, 60, 61]. In addition serum transferrin receptor and reticulocyte hemoglobin equivalent is also an emerging investigation to diagnose the disease [54].
Anemia due to CKD fall under the category of decreased RBC production and prevalence varies from 13.2–27% of geriatric anemia [19, 49]. In a smaller number of cases, no clear-cut causes of anemia are identified and when a clear etiopathogenesis is ruled-out the anemia is defined as unexplained anemia (UA) term unexplained anemia. Although the reasons are still under-explored but common pathophysiological mechanisms seems to be associated with an age-related inflammatory process [62, 63]. These patients with unidentified causes are referred to as unexplained anemia or idiopathic cytopenia of unknown significance. The erythropoietin genesis in the kidney becomes suboptimal due to age related affects or changes. This aspect is still underestimated and unexplored while dealing with unexplained anemia. The prevalence of UA varies from 5.8% to 43.7% of the cases (Table 2). Many researchers have worked on UA, Price EA and fellows have observed mildly increased inflammatory markers and low erythropoietin levels in patients with this entity. Roy CN and associates have observed that testosterone treatment in case of men 65 years or older with UA and low testosterone levels significantly increased the hemoglobin levels. In testosterone trials, testosterone treatment increased Hb levels in both men who had anemia of a known cause and in men with UA [3, 37, 61, 64, 65, 66]. However, similar survival was observed in geriatric patients with UA compared with non-anemic subjects but mortality risks was increased in patients with deficiency anemia compared with non-anemic subjects [49]. The erythropoietin levels seen inappropriately low in UA indicating that decreased erythropoietin production plays an important role in the pathogenesis of anemia of unknown etiology [50]. On further cytogenetic analysis of UA, one researcher found myelodysplastic syndrome in 4% of the total anemic patients [67]. Whereas in others, present somatic mutations were not found fit as per diagnostic criteria for MDS and condition was termed as clonal cytopenia of undetermined significance [68].
Normocytic anemia being the commonest anemiafollowed by microcytic hypochromic and macrocytic as studied by Kim HS et al. The most common pattern of anemia in a study done by Choi CW has been found to be normocytic anemia amounting to 93.5%, and 3.5% of them being microcytic, and 3% were macrocytic anemias. Bhasin A et al. study showed that most common pattern of anemia as normocytic in 60–90 years age group [69, 70, 71].
WHO classified anemia as public health problem in 2008 into mild, moderate and severe category [72]. Most common grade appreciated is mild (57.1%) with mild to moderate anemia commonly affecting females.While severe and life-threatening anemia is confronted in males predominantly [73]. As greater part of the patients are mild anemia only, foremost findings are difficult to observe even pale conjunctiva usually noted when Hb level drops below 9 gm/dL [32]. So this may be the reason that patients of this grade go unnoticed. For example in a study conducted on 1,146 community-dwelling older females it was found that women with Hb levels of 12 to 13 gm/dL perform worse than women with Hb levels of 13 to 15 gm/dL on tests of walking speed, balance and ability to raise from a chair [74]. Across-sectional study including 334 elderly persons was conducted by Pathiana A and fellows in old age home. The overall prevalence of anemia was found to be 68.7%, 47.4% had mild anemia, 47.0% had moderate anemia and 5.6% had severe anemia with 45% of men with mild anemia as compared to 24.8% in women [30].
It has been suggested in the literature that a diagnostic algorithm should be followed and anemia should be classified with a therapeutic orientation. Supplements of iron, micronutrients and erythropoiesis-stimulating agents should constitute the treatment [75].
Anemia in older people is typically mild so it is likely to be overlooked. All elderly persons presenting with health issues should be evaluated for anemia first with complete list of parameters. Proportion and pattern of anemia should be confirmed so that overall outcome and quality of life in case of old age can be improved with specific treatment. Future population-based research is essential for refining for diagnostic testing to tackle out the etiology of geriatric anemia and evaluate effective therapies to reduce the disease burden on the society.
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