\r\n\tThere are generally two types of masonry: brick and stone masonry. Brick masonry: a type of masonry that uses bricks. However, masonry is further divided into "clay work," which uses clay to fill various joints with bricks to build walls, and "cement masonry," the cheapest type of masonry. Masonry: this is the art of building with bricks or stone. The ability of masonry to support the load imposed by the structural elements above it is called strength. The application of loads to masonry creates internal stresses and deformations. The brand of mortar and brick, the shape and size of masonry materials, and the thickness and density of mortar joints affect the strength of masonry. The ability of masonry to maintain its position under horizontal load is called stability. This property limits the height of masonry depending on its thickness and the magnitude of wind loads. The thermal conductivity of bricks of different types (silicate, ceramic, facing, refractory) is considered. A comparison of bricks in terms of their thermal conductivity is made; the thermal conductivity coefficients of refractory bricks are presented at different temperatures - from 20 to 1700°C. The thermal conductivity depends mainly on the density and the configuration of the voids. Architecture and construction consist of various elements for building works, and masonry is the main element with which these constructions are realized. Masonry is a piece of fired clay with a rectangular shape and is used to build walls and structures. Nowadays, eco-masonry can be made of different materials that offer a variety of advantages, but all of them offer benefits at the level of the environment and sustainability; some of these utensils are plastic bottles, clay, etc. The book addresses the holistic issue of using modern masonry in construction. This book interprets masonry as an essential theme of contemporary architecture and sustainable construction. It is one of the most valuable materials in the history of mankind.
",isbn:"978-1-83768-126-6",printIsbn:"978-1-83768-125-9",pdfIsbn:"978-1-83768-127-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"85ef86d046d15e7d4b1988f1ec5dd750",bookSignature:"Prof. Amjad Almusaed and Prof. Asaad Almssad",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12061.jpg",keywords:"Unreinforced Masonry Buildings, Masonry in Sustainable Building, Energy Saving and Masonry, Eco-Friendly Masonry, Modern Architecture and Masonry, Masonry and Human Behavior, Esthetic and Masonry, History of Advanced Masonry, Structural Masonry, Modeling of Masonry Structures, Modern Masonry Manufacturing, Masonry Walls",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 20th 2022",dateEndSecondStepPublish:"July 21st 2022",dateEndThirdStepPublish:"September 19th 2022",dateEndFourthStepPublish:"December 8th 2022",dateEndFifthStepPublish:"February 6th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Prof. Amjad Almusaed, affiliated with Jönköping University has carried out a great deal of research and technical survey work and has performed several studies in these areas. 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PRL has many different roles throughout the body, and most of those are clearly shown as clinical symptom. Perhaps the most important classical role of prolactin is to stimulate milk production in women after the delivery of a baby. Prolactin levels increase during pregnancy causing the mammary glands to enlarge in preparation for breastfeeding and ready to secrete colostrums closely after delivery. Later on the elevated prolactin levels help with the sustained production of milk during nursing. The somatomammotrop cells of the anterior pituitary gland synthesize and secrete prolactin, which is under the control of hypothalamic factors, mainly the tonic inhibition of Dopamine (DA). There are several other sources of PRL-like substances in the periphery such as placental lactogens, (similar to pituitary PRL), mammary gland (produced within the mammary epithelial cells), or PRL variants of immune cell origin (that modulates the immune system). (Gellersen,1989; Andersen 1990; Lkhider, 1996; Kurtz,1993; Gala, 1994, Montgomery,1990; Ben-Jonathan 1996; Yu-Lee LY 1997)
It is important to underline that serum PRL in normal individuals is considered as almost entirely pituitary PRL sources, the above mentioned extra pituitary-PRL may contribute significant amounts but either carries as specific function and target mainly to the local environment acting via paracrine/autocrine manner. (Yu-lee 1997; Bachelot 2007)
During the first several months of breastfeeding, the higher basal prolactin levels also serve to suppress ovarian cyclicity, through the inhibition of pituitary hormones, mainly via LH suppression (Taya 1982) This is the reason why women who are breastfeeding do not get their periods and therefore do not often become pregnant. In actively breastfeeding mothers the related hyperprolactinaemia persisting even over a year. It was observed that extended lactational amenorrhea is associated with low LH levels, and interestingly suckling induced PRL elevation as a response has a positive effect on prolongation. (Diaz 1991; Diaz 1995). Menstruation and ovulation may only occasionally occur before the drop of elevated basal PRL levels. As time goes on with less frequent breastfeeding, e.g. during weaning however, the PRL levels do not stay as high and the woman may start to ovulate. In cases of nonlactating/ nonbreastfeeding mothers, that may happen between 2-3 month after delivery. (Baird 1979)
Similarly, elevated PRL levels are shown during gestation, but mechanisms to inhibit ovulation is related to elevated estardiol and progesterone levels and a consequent depression of pituitary FSH secretion (Marrs 1981).
Generally, the lactogenic hormones play role also in regulation of reproductive function. On one hand, PRL is essential to maintain regular oestrus cycles. PRL knock out mice are completely infertile (Horsemann 1997). One of the other actions of PRL is to stimulate ovarian production of progesterone. That is required in the process of preparation for embryo implantation and it is dependent on a continued estrogen and progesterone secretion by the corpus luteum, which is supported by a functional pituitary during the first half of pregnancy in rodents. (Binart 2000)
On the other hand, high prolactin levels are associated with anovulation or may cause directly or indirectly infertility. In young women, hyperprolactinemia is probably one of the most common endocrine disorders related to pituitary function. Women who are not pregnant and are not breastfeeding should have lower levels of basal PRL (typically 10–28 μg/L in women and 5–10 μg/L in men are defined as “normal levels”) If a non-pregnant woman has abnormally high levels of PRL, it may cause her difficulty in becoming pregnant. It is considered as the most frequent cause of anovulatory sterility, although spontaneous pregnancy may occur occasionally. The prevalence of hyperprolactinemia varies in different patient populations, stays below 1% (0.4% in an unselected normal population) but can be as high as 17% of women with reproductive disorders shown at the clinics (Crosignani 1999)
The suppression of pituitary hormones by PRL, similar that described during lactation has an indirect anovulatory effect. PRL however, acts also directly on the ovary to inhibit the hCG-induced follicle rupture, resulting in the inhibition of ovulation. (Yoshimura 1989).
Clinically significant elevation of PRL levels may cause infertility in several different ways. First, prolactin may stop a woman from ovulating. If this occurs, a woman’s menstrual cycles will stop. In less severe cases, high prolactin levels may only disrupt ovulation once in a while. This would result in intermittent ovulation or ovulation that takes a long time to occur. Women in this category may experience infrequent or irregular periods. Women with the mildest cases involving high prolactin levels may ovulate regularly but not produce enough of the hormone progesterone after ovulation. This is known as a luteal phase defect. Deficiency in the amount of progesterone produced after ovulation may result in a uterine lining that is less able to have an embryo implant. Some women with this problem may see their period come a short time after ovulation (Shibli-Rahhal, 2011)
Hyperprolactinemia is commonly found in both female and male patients with abnormal sexual and/or reproductive function or with galactorrhea. If serum prolactin levels are above 200 μg/L, a prolactin-secreting pituitary adenoma (prolactinoma) is the underlying cause, but if levels are lower, differential diagnoses include the intake of various drugs, compression of the pituitary stalk by other pathology, hypothyroidism, renal failure, cirrhosis, chest wall lesions, or idiopathic hyperprolactinemia. When a pituitary tumour is present, patients often have pressure symptoms in addition to endocrine dysfunction, such as headaches, visual field defects, or cranial nerve deficits (Wang, 2012). The objectives of therapy are to improve the symptoms associated with high PRL levels and to reduce the size of a pituitary tumour.
Pharmacotherapy is available to reduce the tumour size and consequently decrease PRL levels. The large majority of patients with prolactinomas, both micro- and macroprolactinomas, can be successfully treated with dopamine D2 receptor agonists as first-line treatment, with normalization of prolactin secretion and gonadal function, and with significant tumour shrinkage in a high percentage of cases, to prevent the need for surgery. In cases when the only cause of infertility is chronic anovulation due to hyperprolactinemia, a 60-80% pregnancy rate can be achieved. Surgical resection of the prolactinoma is the option for patients who may refuse or do not respond to long-term pharmacological therapy. Radiotherapy and/or estrogens are also reasonable choices if surgery fails. In patients with asymptomatic microprolactinoma no treatment needs to be given and a regular follow-up with serial prolactin measurements and pituitary imaging should be organized (Asa 2002; Crosignani 1999, Molitch 2003).
The most commonly used dopamine agonists are bromocriptine, pergolide, quinagolide and cabergoline. When comparing the plasma half-life, efficacy and tolerability of these drugs are different, there is also important to evaluate the risk/ benefits profile of each product. As the current clinical practice, pharmacological treatment with dopamine agonist plays an important role. The recommendations on the most effective dosages and the advantages of a long term efficacy of products have been evaluated summarizing the results of case histories of the last decades.
A variety of etiological factors including disorders of the hypothalamo-pituitary axis, interruption of dopamine synthesis, stress, pituitary tumours, polycystic ovary syndrome, primary hypothyroidism, and various medications may lead to hyperprolactinemia (5). Hyperprolactinemia in girls causes delayed puberty, hypogonadotropic hypogonadism, primary or secondary amenorrhea, and galactorrhea (Fideleff, 2000). Hyperprolactinemia in men may result in as a first signs of decreased libido or impotence, however also cause inefficient sperm production and infertility (Colao, 2004).
As one of the fist signs in women with high prolactin levels may have irregular periods or no periods at all. Another common symptom is “galactorrhea”, which is the occurrence of a milky discharge from the breast in a woman who has not recently been pregnant. The discharge is the result of persistant high PRL levels stimulating the mammary gland for milk production. Some women may see galactorrhea occur spontaneously. Others may see it only if they squeeze their nipples.
As diagnostic practice, after signs and labtests have been evaluated the magnetic resonance imaging (MRI) of the pituitary gland should be performed in all patients. A pituitary adenoma with a diameter of less than 1 cm is defined as “microadenoma” and one above 1 cm in diameter as “macroadenoma”.
Prolactin can be measured with a simple blood test drawn at the fertility doctor\'s office. In order to get accurate results, prolactin should be drawn first thing in the morning. Since PRL may serve as a hormone to affect reproductive functions, sexual contact, stimulation of nipples in human may cause a not just immediate but also next-day-long alterations of the PRL secretory pattern. (Kruger 2012) These fluctuations are measured on the next day to produce a PRL elevation around noon, additional of the regular circadian rhythm of PRL levels, as the peak on the morning. Accordingly it is important to note that the woman should have the instructions to eat nothing from the night before and to avoid any stimulation of the breast and nipples, included sexual intercourse as well, from the day before also.
Since stimulation of the breast /nipples (stress such as physical exam) may cause immediate release of PRL one common mistake that doctors make is to draw a prolactin blood test immediately after a patient has had a breast exam in the office. These women will have high prolactin levels because of the exam and therefore they may show false (i.e. transient) increase of PRL levels. Prolactin should also be drawn early in the menstrual cycle - before ovulation. This is because prolactin levels are naturally higher after ovulation.
A prolactin level of 5-20 ng/mL is considered normal in both sexes, according to some laboratories and test references the male and female (a bit higher) normal range may differ. A level above 20 ng/mL in two successive measurements is defined as hyperprolactinemia (7). According to WHO standards: 1 μg/L = 21.2 mIU/L. PRL levels > 250 ng/mL usually indication for prolactinoma, when PRL > 500 ng/mL it is considered as diagnosis for macroprolactinoma. (Melmed, 2011)
There are cases when false positive and elevated PRL levels are measured: two high molecular mass forms of prolactin (PRL) in serum have been identified: macroprolactin (big-big PRL, > 100 kDa) and big PRL (40-60 kDa). Big PRL is a consistent “normal” component of total serum PRL but rarely cause of hyperprolactinemia. Macroprolactin is usually a complex of PRL and IgG in composition, it is formed in the circulation from monomeric PRL with a molecular mass of 150-170 kDa, but may have some additional variability in composition. In labor tests the PRL in the complex remains reactive to a variable extent in immunoassays. Individuals may show a different pattern of % of these variants, or even can be a predominant immunoreactive component of circulating PRL and the cause of apparent hyperprolactinemia, but it has minimal bioactivity in vivo and is not of pathological significance. As necessary the reference technique of gel filtration chromatography at the laboratory should be available for confirmation and request on investigation of samples to avoid confusion of diagnostics. (Fahie-Wilson 2005)
Pituitary adenomas are the most common tumour type in the pituitary gland. There is approximately 10% incidence was shown obtained by post-mortem autopsy, with similar ratio of male and female patients. The most frequently detected tumours (over 39%) are sparsely granulated PRL cell adenomas. The others types are GH cell or mixed PRL/GH adenoma, ACTH cell adenoma/Crooke’s cell adenoma (~14%) ; Gonadotroph cell adenoma (6.6%); Null cell adenoma/oncocytoma (~32%) and other or unclassified types (Buurman, 2006).
Invasive tumours with multiple recurrences are only classified as aggressive tumours or "atypical adenomas". Tumours with systemic metastasis must be considered as carcinomas, and “only” make up 0.1% to 0.2% of all pituitary tumours, but with very poor prognostics of 66% mortality (Oh, 2012). However it was suggested that a full picture inlcuded clinical signs (gender, DA-resistant hyperprolactinemia, etc), radiological status (invasive macro or giant tumour) and histological signs of angiogenesis, mitoses level, vascular invasion and molcular biology parameters (Ki-67 > 3 %, p53 positive, up-regulation of genes related to invasion and proliferation, and allelic loss of chromosome 11) should be taken into account considering the potential malignancy, prognosis of prolactin secreting tumours and identify the optimal therapy as early as possible. The key question is to identify factors associated with tumour aggressiveness. The approach combined genomic and transcriptomic analysis focus to the subtype of pituitary tumour able to identify molecular events associated with the aggressive and malignant phenotypes. Allelic loss in certain loci of chromosome 11 has been detected in tumours with signs of malignancy, potentially responsible for triggering the aggressive and malignant phenotypes. Within the recent years there are an increasing number of genes or molecular signs that has been associated with pituitary tumorigenesis to develop predictive and potential prognostic markers. (Zemmoura, 2012; Dworakowska, 2012; Wierinckx 2011)
About one-third of all pituitary tumours are not associated with hypersecretory syndromes but, rather, present with symptoms of an intracranial mass, such as headaches, nausea, vomiting or visual field disturbances. Only rare cases of pituitary tumours are considered as malignant prolactinoma. Tumours that produce growth hormone (GH) may also secrete prolactin in nearly 25% of cases. This is a common source of misdiagnosis, as the features of prolactin excess may capture attention while the more subtle features of GH excess go unnoticed.
In some people, a small group of cells may form a cyst in the pituitary gland which produces elevated levels of prolactin. These cysts are called prolactinomas or pituitary adenomas. It is unclear exactly how these cysts get started. Recent investigations on pituitary tumours reported that approximately 12% of pituitary glands (obtained by autopsy of 3048 patients) are shown histologically diagnosed but clinically inapparent adenoma. Among the mean tumour size is approx 1.9mm. According to published data two-thirds of adenomas has a tumour size <3 mm, half of them were smaller than 1 mm in diameter and ~23% was between 3-10mm. In this study only few (3/76) tumours were identified as macroadenomas corresponding to a tumour size >10 mm. (Buurman, 2006)
The prevalence of clinically apparent prolactinomas ranges from 6–50/ 100,000 in reported populations (Daly, 2006; Fernandez 2010). The prevalence of “ever-treated“ hyperprolactinemia is approximately 20 /100,000 in male patients and approximately 90 /100,000 in female patients. (Kars, 2009)
The adenomas can be seen and measured using MRI and classified based on their size.
Small adenomas are known as microadenomas. They measure less than one centimetre in diameter. This is the most common type of adenoma found. Microadenomas can even be present in healthy people who do not have high prolactin levels. Microadenomas can be treated with medication. They do not grow large and do not need to be treated if hormone levels are normal. Microprolactinomas usually follow a benign course and rarely progress to macroprolactinomas. However, in rare cases microadenoma may transform to other tumours.
A case history it was reported that a microadenoma transformed to macroprolactinoma within 10 month, probably due to estrogen therapy applied. The case report emphasizes the role of dopaminergic agonist in treatment of hyperprolactinemia. (Garcia, 1995)
A case history of a 22 -year-old woman with the signs of galactorrhea and slight hyperprolactinemia, showed 7-mm intrapituitary lesion which responded to treatment with cabergoline. This PRL-secreting microadenoma has a sudden change within 4 years of diagnose. The case represents a rapid evolution from a microprolactinoma initially responding to dopamine agonists to a fatal pituitary carcinoma. (Guastamacchia, 2007)
Adenomas larger than 1 centimetre are called macroadenomas. If untreated, macroadenomas can grow further and start to compress the nearby tissues and structures causing life-threatening events or even fatal outcome. The closest structures are the optic nerves, internal carotid arteries. If a macroadenoma causes compression of the optic nerves, partial blindness can result. For this reason, it is important to treat macroadenomas whether or not a woman is interested in getting pregnant. Medication can be used to treat them but if that fails, surgery may be necessary.
According to a recent clinical study in Japan, treatment with Cabergoline achieved a high pregnancy rate with uneventful outcomes in infertile women with prolactinoma, independent of tumour size and bromocriptine resistance or intolerance. Over 90% of patients in the study conceived pregnancies, and one-third of the macroprolactinomas disappeared. Cabergoline monotherapy could serve as an alternative of the conventional combination bromocriptine therapy with surgery or irradiation in macroprolactinomas. (Ono, 2010)
The hyperprolactinemia of hypothyroidism is related to several mechanisms. In response to the hypothyroid state, a compensatory increase in the discharge of central hypothalamic thyrotropin releasing hormone (TRH) results in increased stimulation of prolactin secretion.
Although TRH was originally named for its ability to trigger the release of thyroid-stimulating hormone (TSH) in mammals, it became apparent that TRH exerts multiple hypophysiotropic activities also in human. Stimulation with TRH will provide a diagnostic test to demonstrate a TSH release curve typical of the subclinic hypothyroidism. PRL is under tonic inhibition by the hypothalamus by way of the PRL inhibitory factor, DA. PRL-releasing factors include TRH., Increased release of TRH may also cause a sustained stimulation of prolactin release from the pituitary gland. There are several clinical reports presented the correlation between subclinic hypothyroidism-hyperprolactinemia and sterility. Treatment with thyroid hormone supplements will result in correction of both the thyroid feedback and the high prolactin levels.
Asymptomatic patients with intact gonadal and reproductive function and moderately elevated prolactin levels may have macroprolactinemia (Vallette-Kasic, 2002). Hypersecretion of PRL by lactotroph cells of the anterior pituitary cause hyperprolactinemia. Patients with hyperprolactinemia may have radiologically undetected microprolactinomas, but some of them may present other causes of hyperprolactinemia characterised as a symptom of macroprolactinemia, with a predominance of higher molecular mass prolactin forms (big-big prolactin, MW > 150 kDa). This term should not be confused with macroprolactinoma, which refers to a large pituitary tumour greater than 10 mm in diameter.
The prevalence of macroprolactinemia varies between 15-46% in hyperprolactinemic populations, and it may because confusing tests results that could not be differentiated from true hyperprolactinemic patients, on the basis of clinical features alone. The pathophysiology of macroprolactinemia is based on a mechanisms of the increased antigenicity of these molecules, leading to the appearance of autoantibodies against PRL, which can consequently reduce the bioactivity of PRL and provide extended half-life. Therefore macroprolactinemia is manifested with less frequent clinical symptoms in macroprolactinemic patients and the tests results mainly due to the delayed clearance of PRL. According to recent publications of Isik et al, evaluating over 300 hyperprolactinemic patients, over 26% of them resulted in elevated macroprolactin levels, with the less frequent signs of galactorrhea or abnormal MRI results compared those to patients with predominant monomer hyperprolactinemia. The other symptoms and frequency of amenorrhea, infertility, irregular menses, gynecomastia, and erectile dysfunction were similar in both groups. (Isik, 2012)
Macroprolactinemic patients have no clinical symptoms of hyperprolactinemia and may have no pituitary adenomas. It is still controversial whether macroprolactinemia is a benign condition that does not need further investigation and treatment. Patients can be screened for macroprolactinemia by PEG (polyethylene glycol) precipitation as a standard laboratory test with a results of recovery of ≤40% to normal monomeric PRL level is used as an indication of macroprolactinemia (Tamer, 2012). The clinical importance of this test is based on the lower prevalence of pituitary adenomas in this group, compared to “true hyperprolactinemic” patients.
PCOS is a common problem that can cause infertility by inhibiting ovulation, affecting 3.5-10% of the reproductive age of women. For unknown reasons, some women with PCOS may have slightly high PRL levels. PCOS similar to hypoprolactinemic are both common causes of secondary amenorrhoea in women. The relationship between PCOS and hyperprolactinemia so far has been reported still with controversial results: it seems that PCOS is very prevalent with hyperprolactinemia, nevertheless there are different reasons of altered regulation of gondotropin secretion, and suggests that these conditions have independent origins. Recent investigators using serial serum sampling have excluded transient elevations of PRL and have shown a less frequent association of these two disorders. According to clinical guidelines PCOS patients with increased PRL levels must be investigated for other causes of hyperprolactinemia, because hyperprolactinemia may be due to a reason of concomitant disease, but not proved the cause-relationship to PCOS. Treatment of infertility associated with PCOS has changed in the last decade due to the introduction of new medications such as insulin-sensitizing drugs, aromatase inhibitors, gonadotropin treatment etc. (Bracero 2001, Urman, 2006, Escobar-Morreale, 2004)
In a study conducted in Brazil, among the 82 PCOS women, 13 (16%) presented high PRL levels (over 100 microg/l). There were several reasons of hyperprolactinemia: pituitary adenoma; drug-induced hyperprolactinemia, or macroprolactinemia. The non-hyperprolactinemic PCOS patients (over 80%) represented normal PRL levels. The authors concluded that hyperprolactinemia is not a clinical manifestation of PCOS. (Filho, 2007)
Some medications can cause higher levels of prolactin to be produced. The most common medications that do this are known as anti-psychotic medications. The antipsychotics mostly act as dopaminergic neurotransmitters/ receptor blockers can also cause endocrine side effects, as hyperprolactinaemia and it is most common side effect of first-generation antipsychotics. The second- and thirdgeneration antipsychotics have a weaker affinity for D2 dopamine receptors, thus hyperprolactinemia is less common when such medication is used. (Uzun et al. 2005). The risk of side effects caused by antipsychotics is individual and it does not depend solely on the therapeutic dose and may have influence on some predisposing conditions. (Ružić 2011)
Other medications which may increase prolactin levels:
Some types of anti-depressants, serotonin reuptake inhibitors, SRIs (fluvoxamine; fluoxetine; paroxetine, duloxetine etc)
Some types of sedatives
Catecholamine depletor
Dopamine synthesis inhibitor
Neuropeptides
Anticonvulsants
Opiates and opiate antagonists
Estrogen Oral contraceptives (birth control pills)
Some types of blood pressure medications (methyldopa, verapamil)
A medication for nausea (Reglan, metoclopramide)
Antacids (cimetidine)
A high prolactin level can sometimes be related to physical stress. Even drawing blood can by itself cause someone to produce and immediate prolactin-release. PRL eleveation can also detected in response to strong or sudden external stimuli in general, such as stressful environmental conditions, or can be related to physchological reasons. This latter can be evaluated by stress profile or measured by experimental conditions, such as “Screamer Index”, which is shown resulting in values to be parallel to levels of hyperprolactinemia in women. (Harrison, 1988; Cepisky, 1992). On the other hand, anxiety and irritability maybe a result of hyperprolactinemia. In rat models PRL increased the stimulatory effect of ACTH-induced corticosterone secretion (Jaroenporn, 2007).
Endocrine abnormalities are frequently associated with a wide range of psychological symptoms. These symptoms may reach the level of psychiatric illness (mainly mood and anxiety disorders) or just being identified by the subclinical forms of assessment provided by the Diagnostic Criteria for Psychosomatic Research (DCPR). In a population study reported by Sonino et al, (2007), the majority of patients suffered from at least one of the three DCPR syndromes considered: irritable mood (over 45%), demoralization, persistent somatization. Long-standing endocrine disorders may imply a degree of irreversibility of the pathological process. Endocrine treatment may cause even the worsening of psychological symptoms. The methodology and assessment score provided by DCPR tests have been demonstrated to be a valuable tool for psychological assessment in endocrine disease from diagnostic to follow-up periods. (Sonino 2007)
In clinical environment the variability of PRL concentration in random estimations underline the need for special testing to rule out stress-related hyperprolactinemia and diagnostic pitfalls. It was recommended by the results, that two or three serial PRL determinations in resting conditions provide more reliable results (Muneyyirci-Delale, 1989).
In experimental conditions, hyperprolactinemia and stress interact differentially according to the length of the stimuli and that is connected to the immune response modulated by PRL. Surgical or restraint stress induce marked (2x- 4x) increase of plasma PRL of control rats, but interestingly did not change the PRL levels of hyperprolactinemic rats. In both cases the plasma glucose levels reported elevated (Reis, 1996).
It is suggested as a result of a retrospective observational study, that life events such as changes in subject’s social or personal environment indicated that these stressful conditions may provoke hyperprolactinemia. Even an exposure during childhood to a stressful environment maybe associated with hyperprolactinemia and/or galactorrhea later in life as a response to specific environmental changes (Sobrinho, 1984). Patients with hyperprolactinemia reported significantly more life events, these events rated as being of „moderate”, marked or severe „negative” impact compared with control subjects (Sonino, 2004).
There is evidence that several external stress-factors may contribute to the occurrence of hyperprolactinemia. In theory, stress might have been involved in facilitation of a clonal proliferation of a single mutated cell and cause prolactinomas. Patients in functional hyperprolactinemic status, stress might trigger neuroendocrine changes involving DA and/or serotonin, which both can consequently affect PRL release. (Verhelst, 2003; Freeman, 2000; Fava, 1981.)
Prolactin is a pituitary-derived hormone that plays an important role in a variety of reproductive functions. It is an essential factor for normal production of breast milk following childbirth. Additionally, prolactin negatively modulates the secretion of pituitary hormones responsible for gonadal function, including luteinizing hormone and follicle-stimulating hormone. Clnincally significant hyperprolactinemia may result in hypogonadism, infertility, and galactorrhea, or in some cases it may remain asymptomatic for a long period. (Klibanski 2010) The most commonly cited indications for treatment of microprolactinomas is infertility and hypogonadism. Hypogonadism and infertility associated closely with the treatment: DA agonists can restore normal PRL levels and consequently the normal gonadal function. According to the date of a meta-analyis, patients treated with bromocriptine had normalization of prolactin levels and it was successful in 53% of patients with infertility. Studies with cabergoline showed similar results: cabergoline was shown more effective than bromocriptine reducing PRL levels, or in symptoms of amenorrhea/oligomenorrhea, or in some of the patient-important outcomes. (Gillam 2006; Wang 2012)
Prolactin is under dual regulation by hypothalamic hormones delivered through the hypothalamic–pituitary portal circulation. The differential diagnosis and causes of pathological hyperprolactinemia are summarized in Figure 1.
The predominant signal is inhibitory, preventing prolactin release, and is mediated by the neurotransmitter dopamine. The stimulatory signal is mediated by the hypothalamic TRH. The balance between the two opposite signals determines the amount of prolactin released from the anterior pituitary gland (Verhelst; 2003).
Prolactin is under dual control from the hypothalamus.
The first steps in cases of signs of hyperprolactinemia should be a critical diagnosis, as discussed above, may involve dynamic testings, assessment for macroprolactinemia and further laboratory tests to eliminate false positive or negative results.
Consider other underlying causes, such as suspected drug-induced hyperprolactinemia, hypothyroidism, elimination/renal failure, other persistent pituitary and parasellar tumours, etc.
Identify the size of pituitary tumour and other anatomical circumstances.
Apply pharmacotherapy treatment specified to patient
The major steps of diagnosis of hyperprolactinemia is summarized in Figure 2.
Approach to diagnosis of hyperprolactinemia.
Specific recommendations for diagnosis of hyperprolactinemia include the following (Melmed 2011):
A single measurement of serum prolactin level can confirm the diagnosis if the level is above the upper limit of normal and the serum sample was obtained without excessive venipuncture stress. Dynamic testing of prolactin secretion is not recommended to diagnose hyperprolactinemia.
Macroprolactin evaluation is recommended in patients with asymptomatic hyperprolactinemia.
When there is a discrepancy between a very large pituitary tumour and a mildly elevated prolactin level, serial dilution of serum samples is recommended to eliminate the "hook effect," or an artifact that can occur with some immunoradiometric assays leading to a falsely low prolactin value.
Specific recommendations for management of drug-induced hyperprolactinemia are as follows (Melmed 2011):
In a symptomatic patient with suspected medication-induced hyperprolactinemia, the drug should be discontinued for 3 days or an alternative drug substituted, and the serum prolactin measurement should then be repeated. However, the patient\'s physician should be consulted before an antipsychotic agent is discontinued or substituted. If the drug cannot be discontinued and the onset of the hyperprolactinemia does not coincide with starting therapy, magnetic resonance imaging (MRI) of the pituitary gland may distinguish medication-induced hyperprolactinemia from symptomatic hyperprolactinemia caused by a pituitary or hypothalamic mass.
Patients with asymptomatic medication-induced hyperprolactinemia should not be treated. Estrogen or testosterone can be used in patients with long-term hypogonadism (hypogonadal symptoms or low bone mass) caused by medication-induced hyperprolactinemia.
If it is not possible to stop the drug causing medication-induced hyperprolactinemia, cautious administration of a dopamine agonist should be considered, in consultation with the patient\'s physician.
As noted above, prolactin levels can often be corrected by stopping suspected medication or switching to a different medication type. Correction of hypothyroidism is also effective and specific to reduce PRL levels. If prolactin levels are persistently high, they can be effectively treated with a group of medications known as dopamine agonists.
According to our clinical practice patients with macroadenoma suggested to undergo transsphenoidal pituitary surgery. Medical treatment is given to the subjects with microadenoma, persistent postoperative hyperprolactinemia, and to those cases of hyperprolactinemia when it is caused by other medications.
From the available mediactions Bromocriptine 2.5 mg (Parlodel®, Novartis) once or twice a day or cabergoline 0.5 mg (Dostinex®, Pharmacia) once or twice a week is given as prolactin-lowering drug.
Parlodel is an effective and inexpensive medication for high prolactin levels. Parlodel is usually taken at bedtime with a snack. This is because Parlodel will occasionally cause dizziness or stomach upset, so taking it before sleep and with food will reduce those side effects. Generally with time, the side effects stop anyway.
The prolactin levels can be rechecked in about three weeks. If the levels are still elevated the dose can be increased or a different medication can be tried. The administration of Parlodel can be stopped upon diagnosis of pregnancy. However, if a woman has a macroadenoma, Parlodel should be continued through pregnancy and delivery.
Due to the side effects, some women can not tolerate Parlodel. For these women, they may try alternatives, e.g. vaginal bioadhesive suppositories or inserted the pills vaginally instead of taking them orally.
Because it is more expensive, cabergoline is not usually the first choice for treatment of high prolactin levels. It is usually used when Parlodel is ineffective or a woman cannot tolerate the side effects. Cabergoline is a longer acting medication. It is usually given twice a week instead of every day.
The Endocrine Society has released a new clinical practice guideline for the diagnosis and treatment of patients with hyperprolactinemia (Melmed, 2011). The new recommendations for management of elevated levels of the PRL, which is associated with infertility, low sex drive, and bone loss, are listed.
Specific recommendations for management of prolactinoma are as follows (Melmed 2011)::
Dopamine agonist therapy is recommended to reduce prolactin levels and tumor size and to restore gonadal function in patients with symptomatic prolactin-secreting microadenomas or macroadenomas. Compared with other dopamine agonists, cabergoline is more effective in normalizing prolactin levels and in shrinking pituitary tumours.
Dopamine agonists are not recommended for asymptomatic patients with microprolactinomas. However, patients with microadenomas who have amenorrhea can be treated with a dopamine agonist or oral contraceptives.
In patients treated with dopamine agonists for at least 2 years who no longer have elevated serum prolactin levels or visible tumour on MRI, careful clinical and biochemical follow-up therapy may be tapered and perhaps discontinued.
Specific recommendations for management of resistant and malignant prolactinoma are as follows (Melmed 2011):
For symptomatic patients in whom normal prolactin levels are not achieved or who have significant shrinking of the tumour size while receiving standard doses of a dopamine agonist, the dose should be increased rather than referring the patient for surgery.
Patients resistant to bromocriptine should be switched to cabergoline.
Symptomatic patients with prolactinomas who cannot tolerate high doses of cabergoline or who are unresponsive to dopamine agonist therapy should be offered trans-sphenoidal surgery. Patients intolerant of oral bromocriptine may respond to intravaginal administration. Radiation therapy is recommended for patients in whom surgical treatment fails or for those with aggressive or malignant prolactinomas.
Temozolomide therapy is recommended for patients with malignant prolactinomas.
Specific recommendations for management of prolactinoma during pregnancy are as follows (Melmed 2011):
Women with prolactinomas should discontinue dopamine agonist therapy as soon as pregnancy is recognized, except for selected patients with invasive macroadenomas or adenomas abutting the optic chiasm.
Serum prolactin measurements should not be performed during pregnancy.
Unless there is clinical evidence for tumour growth, such as visual field impairment, routine use of pituitary MRI during pregnancy is not recommended in patients with microadenomas or intrasellar macroadenomas.
Women with macroprolactinomas that do not shrink during dopamine agonist therapy or women who cannot tolerate bromocriptine or cabergoline should be counselled regarding the potential benefits of surgical resection before attempting pregnancy.
Pregnant women with prolactinomas who experience severe headaches and/or visual field changes should have formal visual field assessment followed by MRI without gadolinium.
Bromocriptine therapy is recommended in patients who experience symptomatic growth of a prolactinoma during pregnancy.
Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. A recently published study demonstrated that hyperprolactinemia in mice induced anovulation, reduced GnRH and gonadotropin secretion, and diminished kisspeptin expression. Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. This study indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists (Sonigo, 2012).
To sum up, the systematic reviews and meta-analyses affirm the use of dopamine agonists in treating hyperprolactinemia and reducing associated morbidity. Cabergoline was found to be more effective than bromocriptine in achieving normoprolactinemia and resolving amenorrhea/oligomenorrhea and galactorrhea. Radiotherapy and surgery are efficacious in patients with resistance or intolerance to dopamine agonists (Wang, 2012).
Prolactin-secreting pituitary tumours are a common cause of amenorrhea and infertility in premenopausal women. The goals of therapy are to normalize prolactin, restore gonadal function and fertility, and reduce tumour size, and dopamine agonists are the preferred therapy. Clinically significant tumour enlargement during pregnancy is uncommon and dependent on tumour size and pre-pregnancy treatment.
Accroding to over 180 clinical study reports (across 3000 patients) treatment with bromocriptine or with cabergoline are both effective in normalization of prolactin levels and also successful in restoration of fertility over 53% of patients. Cabergoline was shown more effective than bromocriptine in persistent hyperprolactinemia, and reducing the symptoms of amenorrhea/oligomenorrhea. At our institution patients with symptomatic prolactinomas, both micro- and macroadenomas, are treated with cabergoline as the first-line approach. In the small group of patients who do not respond to this treatment, or who refuse long-term therapy, surgery is offered. Radiotherapy is given if both pharmacologic therapy and surgery fail.
In the field of physics and applied mathematics research getting an exact solution of a nonlinear partial differential equation is very important. The elaboration of many complex phenomena in fluid mechanics, plasma physics, optical fibers, biology, solid-state physics, etc. is possible if analytical solutions can be obtained. Most of the differential equation arises in these field has no explicit solution as popularly known. This problem creates hindrances in the study of nonlinear phenomena and makes it time-consuming in the research of nonlinear models in the plasma and other science. However recent researches in nonlinear differential equations have seen the development of many approximate analytical solutions of partial and ordinary differential equations.
\nThe history behind the discovery of soliton is not only interesting but also significant. In 1834 a Scottish scientist and engineer—John Scott-Russell first noticed the solitary water wave on the Edinburgh Glasgow Canal. In 1844 [1] in “Report on Waves” he accounted his examinations to the British Association. He wrote “I was observing the motion of a boat which was rapidly drawn along a narrow channel by a pair of horses, when the boat suddenly stopped not so the mass of water in the channel which it had put in motion; it accumulated round the prow of the vessel in a state of violent agitation, then suddenly leaving it behind, rolled forward with great velocity, assuming the form of a large solitary elevation, a rounded, smooth and well defined heap of water, which continued its course along the channel apparently without change of form or diminution of speed. I followed it on horseback and overtook it still rolling on at a rate of some eight or nine miles an hour, preserving its original figure some thirty feet long and a foot to a foot and a half in height. Its height gradually diminished and after a chase of one or two miles I lost it in the windings of the channel. Such in the month of August 1834 was my first chance interview with that singular and beautiful phenomenon which I have called the Wave of Translation.” He coined the word “solitary wave.” The solitary wave is called so because it often occurs as a single entity and is localized. The most important characteristics of solitary waves were unearthed after thorough study along with extensive wave-tank experiments. The following are the properties of solitary waves:
\n(a) These localized bell-shaped waves travel with enduring form and velocity. The speed of these waves are given by \n
John Scott-Russell’s study created a stir in the scientific community. His study not only initiated a debate with the prevailing knowledge of the theories of waves but also challenged the antecedent knowledge of waves. The previous study claimed that a periodic wave of finite amplitude and permanent shape are feasible only in deep water unlike Russell’s observation that the permanent profile is also possible in shallow water. Finally the stable form of solitary waves was received in scientific community with the aid of nonlinearity and dispersion. An ideal equilibrium between nonlinearity and dispersion can generate such waves.
\nDiederik Johannes Korteweg in 1895 [2] along with his PhD student Gustav De Vries obtained an equation from the primary equation of hydrodynamics. This equation explains shallow water waves where the existence of solitary waves was mathematically recognized. This equation is called KdV equation which is of the form \n
This chapter will discuss the analytical solitary wave solution of the KdV and KdV-like equations. In the study of nonlinear dispersive waves, these equations are generally seen. The KdV equation, a generic equation, is important in the study of weakly nonlinear long waves. This equation consists of a single humped wave characterized by several unique properties. The Soliton solutions of the KdV equation have been quite popular but it also not devoid of problems. The problems not only restrict to dispersion but also dissipation and interestingly these are not dominated by the KdV equation. The standard KdV equation fails to explain the development of small-amplitude solitary waves in case the particles collide in a plasma system. KdV equation with an additional damping term or the damped Korteweg-de Vries (DKdV) equation becomes handy in explaining this issue of elaborating the character of the wave. But in the presence of any critical physical situation (critical point) nonlinearity of the KdV equation disappears and the amplitude of the waves reaches infinity. To control this situation, a new nonlinear partial differential equation has to be derived that can explain the system at that critical point. This is known as the modified Korteweg-de Vries (MKdV) equation. In the presence of collisions, this equation is not also adequate and a damped MKdV equation is necessary. Also in the presence of force source term then the equation will be further modified and become DFKdV/DFMKdV.
\nNow we will derive the KdV equation from a classic plasma model, in which we consider a collision-free unmagnetized plasma consists of electrons and ions, in which ions are mobile and electrons obey the Maxwell distribution. The basic equation will be given as:
\nwhere the electrons obey Maxwell distribution, i.e., \n
To write Eqs. (1)–(3) in dimensionless from we introduce the following dimensionless variables
\nwhere \n
To linearized (5)–(7), let us write the dependent variable as sum of equilibrium and perturbed parts, so that we write \n
neglecting the nonlinear term \n
which is the linearized form of Eq. (5).
\nPutting \n
Neglecting the nonlinear term from (10), we get
\nThis is the linearized form of Eq. (6).
\nPutting \n
Hence Eqs. (9), (11), (12) are the linearized form of Eq. (5)–(7) respectively.
\nTo get dispersion relation for low frequency wave let us assume that the perturbation is proportional to \n
So,
\nPutting these value in Eqs. (9), (11) and (12), we get,
\nSince the system (22)–(24) is a system of linear homogeneous equation so for nontrivial solutions we have
\nThis is the
For small \n
The phase velocity as
\nso that \n
In this case, we have \n
For long-wave as \n
The \n
Now the phase of the waves can be written as
\nHere \n
Let us consider a new stretched coordinates \n
where \n
where
We can express (5)–(7) in terms of \n
Substituting the Eqs. (31)–(34) in Eqs. (38)–(40) and collecting the lowest order \n
Integrating Eqs. (41)–(43) and all the variables tend to zero as \n
From Eq. (44)–(46) we get the phase velocity as
\nSubstituting the Eqs.(31)–(34) in Eqs. (38)–(40) and collecting order \n
Differentiating Eq. (50) With respect to \n
Eq. (51) is known as
The steady-state solution of this KdV equation is obtained by transforming the independent variables \n
The steady state solution of the KdV Eq. (51) can be written as
\nwhere \n
Solitary wave solution of
Let us consider an unmagnetized collisional dusty plasma that contains cold inertial ions, stationary dusts with negative charge and Maxwellian electrons. The normalized ion fluid equations which include the equation of continuity, equation of momentum balance and Poisson’s equation, governing the DIAWs, are given by
\nwhere \n
where \n
The normalized electron density is given by
\nWe introduced the same stretched coordinates use in Eq.(31). The expansion of the dependent variables also considered as (32)–(34) with
\nSubstituting (31)–(34) and (58)–(59) along with stretching coordinates into Eqs. (53)–(55) and equating the coefficients of lowest order of \n
Taking the coefficients of next higher order of \n
where \n
It has been noticed that the behavior of nonlinear waves changes significantly in the presence of external periodic force. It is paramount to note that the source term or forcing term due to the presence of space debris in plasmas may be of different kind, for example, Gaussian forcing term [4], hyperbolic forcing term [4], (in the form of \n
which is termed as
In absence of \n
where \n
In this case, it is well established that
\nis a conserved. For small values of \n
where \n
Differentiating Eq. (64) with respect to \n
Again,
\nUsing Eq. (66) and (67) the expression of \n
Therefore, the solution of the Eq. (62) is
\nwhere \n
Solitary wave solution of
In Figure 3, the soliton solution of the damp force KdV equation is plotted from Eq. (65) for different values of the strength of the external periodic force \n
Variation of solitary wave from
Variation of solitary wave from
To obtain damped KdV Burgers equation we considered an unmagnetized collisional dusty plasma which contains cold inertial ions, stationary dusts with negative charge and Maxwellian distributed electrons. The normalized ion fluid equations are as follows
\nwhere \n
Here normalization is taken as follows
\n\n\n
To obtain damped KdV burger we introduced the same stretched coordinates use in Eq.(31). The expansion of the dependent variables are also considered same as (32)–(34) with
\nSubstituting the above expansions (32)-(34) and (73)–(74) along with stretching coordinates (31) into Eqs. (69)–(71) and equating the coefficients of lowest order of \n
Taking the coefficients of next higher order of \n
where \n
In absence of \n
where amplitude of the solitary waves \n
It is well established for the KdV equation that,
\nis a conserved quantity [7].
\nFor small values of \n
where the amplitude \n
Differentiating Eq. (78) with respect to \n
where,
\nand
\nSubstituting Eq. (81) and (82) into Eq. (80), we obtain
\nwhich is the Bernoulli’s equation, where \n
The solution of the Eq. (83) is
\nTherefore, the slow time dependence form of the ion acoustic solitary wave solution of the DKdVB Eq. (76) is given by (79)where.
\n\n\n
Let us consider an unmagnetized collisional dusty plasma that contains cold inertial ions, stationary dusts with negative charge and Maxwellian distributed electrons. The normalized ion fluid equations which include the equation of continuity, equation of momentum balance and Poisson’s equation, governing the DIAWs, are given by
\nwhere \n
where \n
The normalized \n
We introduced the same stretched coordinates use in Eq. (31). The expansion of the dependent variables also considered same as (32)–(34) and (58)–(59). Substituting (31)–(34) and (58)–(59) along with stretching coordinates into Eqs. (84)–(86) and equating the coefficients of lowest order of \n
with \n
where \n
Now at the certain values, for example \n
and expand of the dependent variables same as Eqs. (32)–(34) with
\nNow substituting Eq. (32)–(34) and (91)–(93) into the basic Eqs. (84)–(86) and equating the coefficients of lowest order of \n
Equating the coefficients of next higher order of \n
Equating the coefficients of next higher order of \n
where \n
From Eq. (94)–(96), one can obtain the Phase velocity as \n
where \n
It has been noticed that the behavior of nonlinear waves changes significantly in the presence of external periodic force. For simplicity, we assume that \n
Such a form of this source function is observed in experimental situations or conditions for a particular device. Eq. (104) is termed as
In absence of \n
The slow time dependence form of the ion acoustic waves solution of the DFMKdV Eq. (104) is given by,
\nwhere \n
The amplitude and width are as follows:
\nwhere
\nLet us consider a plasma model [9] consisting of cold ions, Maxwellian electrons in the presence of dust particles and the external static magnetic field \n
The normalized electron density is given by
\nwhere \n
Here the normalization is done as follows:
\nHere \n
To obtain the DFZK equation we introduce the new stretched coordinates as
\nwhere \n
Substituting the equations (112)-(119) into the system of Eqs. (106)-(110) equating the coefficient of \n
Equating the coefficient of \n
Considering the coefficient of \n
Comparing the coefficients of \n
Using the relationships (120)–(124), one can obtain the linear dispersion relation as
\nExpressing all the perturbed quantities in terms of \n
where
\nChoudhury et al. [5] studied analytical electron acoustic solitary wave (EASW) solution in the presence of periodic force for an unmagnetized plasma consisting of cold electron fluid, superthermal hot electrons and stationary ions. Motivated by the these works, here we consider the source term as \n
where \n
where \n
where, \n
The analytical solitary wave solution of the Eq. (134) as obtained in (68), is
\nwhere \n
It is clear from the structure of the solitary wave solution of the DFKdV, DFMKdV and DFZK that the soliton amplitude and width depends on the nonlinearity and dispersion of the evolution equations, which are the function of different plasma parameter involve in the consider plasma system. Also evident from the structure of the approximate analytical solution that the amplitude and the width of the soliton depends on the Mach number \n
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This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. 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H. Gulrez, Saphwan Al-Assaf and Glyn O Phillips",authors:[{id:"58120",title:"Prof.",name:"Saphwan",middleName:null,surname:"Al-Assaf",slug:"saphwan-al-assaf",fullName:"Saphwan Al-Assaf"}]}],mostDownloadedChaptersLast30Days:[{id:"35255",title:"Mechanical Transmissions Parameter Modelling",slug:"mechanical-transmissions-parameter-modelling",totalDownloads:7458,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"1982",slug:"mechanical-engineering",title:"Mechanical Engineering",fullTitle:"Mechanical Engineering"},signatures:"Isad Saric, Nedzad Repcic and Adil Muminovic",authors:[{id:"101313",title:"Prof.",name:"Isad",middleName:null,surname:"Saric",slug:"isad-saric",fullName:"Isad Saric"}]},{id:"68505",title:"Research Design and Methodology",slug:"research-design-and-methodology",totalDownloads:25181,totalCrossrefCites:9,totalDimensionsCites:18,abstract:"There are a number of approaches used in this research method design. The purpose of this chapter is to design the methodology of the research approach through mixed types of research techniques. The research approach also supports the researcher on how to come across the research result findings. In this chapter, the general design of the research and the methods used for data collection are explained in detail. It includes three main parts. The first part gives a highlight about the dissertation design. The second part discusses about qualitative and quantitative data collection methods. The last part illustrates the general research framework. The purpose of this section is to indicate how the research was conducted throughout the study periods.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Kassu Jilcha Sileyew",authors:[{id:"292841",title:"Ph.D.",name:"Kassu",middleName:null,surname:"Jilcha Sileyew",slug:"kassu-jilcha-sileyew",fullName:"Kassu Jilcha Sileyew"}]},{id:"67558",title:"Polymerase Chain Reaction (PCR): Principle and Applications",slug:"polymerase-chain-reaction-pcr-principle-and-applications",totalDownloads:10685,totalCrossrefCites:8,totalDimensionsCites:18,abstract:"The characterization of the diversity of species living within ecosystems is of major scientific interest to understand the functioning of these ecosystems. It is also becoming a societal issue since it is necessary to implement the conservation or even the restoration of biodiversity. Historically, species have been described and characterized on the basis of morphological criteria, which are closely linked by environmental conditions or which find their limits especially in groups where they are difficult to access, as is the case for many species of microorganisms. The need to understand the molecular mechanisms in species has made the PCR an indispensable tool for understanding the functioning of these biological systems. A number of markers are now available to detect nuclear DNA polymorphisms. In genetic diversity studies, the most frequently used markers are microsatellites. The study of biological complexity is a new frontier that requires high-throughput molecular technology, high speed computer memory, new approaches to data analysis, and the integration of interdisciplinary skills.",book:{id:"7728",slug:"synthetic-biology-new-interdisciplinary-science",title:"Synthetic Biology",fullTitle:"Synthetic Biology - New Interdisciplinary Science"},signatures:"Karim Kadri",authors:[{id:"290766",title:"Dr.",name:"Kadri",middleName:null,surname:"Karim",slug:"kadri-karim",fullName:"Kadri Karim"}]},{id:"62059",title:"Types of HVAC Systems",slug:"types-of-hvac-systems",totalDownloads:12466,totalCrossrefCites:9,totalDimensionsCites:15,abstract:"HVAC systems are milestones of building mechanical systems that provide thermal comfort for occupants accompanied with indoor air quality. HVAC systems can be classified into central and local systems according to multiple zones, location, and distribution. Primary HVAC equipment includes heating equipment, ventilation equipment, and cooling or air-conditioning equipment. Central HVAC systems locate away from buildings in a central equipment room and deliver the conditioned air by a delivery ductwork system. Central HVAC systems contain all-air, air-water, all-water systems. Two systems should be considered as central such as heating and cooling panels and water-source heat pumps. Local HVAC systems can be located inside a conditioned zone or adjacent to it and no requirement for ductwork. Local systems include local heating, local air-conditioning, local ventilation, and split systems.",book:{id:"6807",slug:"hvac-system",title:"HVAC System",fullTitle:"HVAC System"},signatures:"Shaimaa Seyam",authors:[{id:"247650",title:"M.Sc.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"},{id:"257733",title:"MSc.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"},{id:"395618",title:"Dr.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"}]},{id:"70315",title:"Some Basic and Key Issues of Switched-Reluctance Machine Systems",slug:"some-basic-and-key-issues-of-switched-reluctance-machine-systems",totalDownloads:1268,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Although switched-reluctance machine (SRM) possesses many structural advantages and application potential, it is rather difficult to successfully control with high performance being comparable to other machines. Many critical affairs must be properly treated to obtain the improved operating characteristics. This chapter presents the basic and key technologies of switched-reluctance machine in motor and generator operations. The contents in this chapter include: (1) structures and governing equations of SRM; (2) some commonly used SRM converters; (3) estimation of key parameters and performance evaluation of SRM drive; (4) commutation scheme, current control scheme, and speed control scheme of SRM drive; (5) some commonly used front-end converters and their operation controls for SRM drive; (6) reversible and regenerative braking operation controls for SRM drive; (7) some tuning issues for SRM drive; (8) operation control and some tuning issues of switched-reluctance generators; and (9) experimental application exploration for SRM systems—(a) wind generator and microgrid and (b) EV SRM drive.",book:{id:"8899",slug:"modelling-and-control-of-switched-reluctance-machines",title:"Modelling and Control of Switched Reluctance Machines",fullTitle:"Modelling and Control of Switched Reluctance Machines"},signatures:"Chang-Ming Liaw, Min-Ze Lu, Ping-Hong Jhou and Kuan-Yu Chou",authors:[{id:"37616",title:"Prof.",name:"Chang-Ming",middleName:null,surname:"Liaw",slug:"chang-ming-liaw",fullName:"Chang-Ming Liaw"},{id:"306461",title:"Mr.",name:"Min-Ze",middleName:null,surname:"Lu",slug:"min-ze-lu",fullName:"Min-Ze Lu"},{id:"306463",title:"Mr.",name:"Ping-Hong",middleName:null,surname:"Jhou",slug:"ping-hong-jhou",fullName:"Ping-Hong Jhou"},{id:"306464",title:"Mr.",name:"Kuan-Yu",middleName:null,surname:"Chou",slug:"kuan-yu-chou",fullName:"Kuan-Yu Chou"}]}],onlineFirstChaptersFilter:{topicId:"1",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83153",title:"Perspective Chapter: Cryptocurrencies Effectiveness for Nature",slug:"perspective-chapter-cryptocurrencies-effectiveness-for-nature",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106493",abstract:"The rise of cryptocurrencies based on Blockchain platforms have provided multiple solutions for social and nature projects supported by concerned investors with sustainable development initiatives. Speculation and unclear uses of a cryptocurrency plays a negative role for the projects they claim to support. A positive relationship between coin investors and supported projects must position the coin value on the scale of the community involvement among the coin and project issues, thus placing the project results above speculative moves. Coin nature and social based projects may include a decentralized autonomous organization (DAO), combined with a digital currency to contribute to social and nature improvements. This organization provides a framework for the engagement of investors, beneficiaries, and implementation partners, with results measured by reliable third parties. The potential funding from non fiduciary sources for sustainable development targets may be framed under the fundraising and financial solutions models, addressing the cryptocurrency volatility risks with responsible tokenomics in attention to transaction and regulatory issues. Overall, the more clear are the object and transaction issues of a nature conservation project supported by a currency, the more successful it will be in terms of nature and social improvements and the currency valuation for all parties involved.",book:{id:"11551",title:"Blockchain",coverURL:"https://cdn.intechopen.com/books/images_new/11551.jpg"},signatures:"Luiz Cruz Villares"},{id:"83163",title:"Robust Control Algorithm for Drones",slug:"robust-control-algorithm-for-drones",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105966",abstract:"Drones, also known as Crewless Aircrafts (CAs), are by far the most multi - level and multi developing technologies of the modern period. This technology has recently found various uses in the transportation area, spanning from traffic monitoring applicability to traffic engineering for overall traffic flow and efficiency improvements. Because of its non-linear characteristics and under-actuated design, the CA seems to be an excellent platform to control systems study. Following a brief overview of the system, the various evolutionary and robust control algorithms were examined, along with their benefits and drawbacks. In this chapter, a mathematical and theoretical model of a CA’s dynamics is derived, using Euler’s and Newton’s laws. The result is a linearized version of the model, from which a linear controller, the Linear Quadratic Regulator (LQR), is generated. Furthermore, the performance of these nonlinear control techniques is compared to that of the LQR. Feedback-linearization controller when implemented in the simulation for the chapter, the results for the same was better than any other algorithm when compared with. The suggested regulatory paradigm of the CA-based monitoring system and analysis study will be the subject of future research, with a particular emphasis on practical applications.",book:{id:"11522",title:"Aeronautics - New Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11522.jpg"},signatures:"Parul Priya and Sushma S. Kamlu"},{id:"83171",title:"Some Results on the Non-Homogeneous Hofmann Process",slug:"some-results-on-the-non-homogeneous-hofmann-process",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106422",abstract:"The classical counting processes (Poisson and negative binomial) are the most traditional discrete counting processes (DCPs); however, these are based on a set of rigid assumptions. We consider a non-homogeneous counting process (which we name non-homogeneous Hofmann process – NHP) that can generate the classical counting processes (CCPs) as special cases, and also allows modeling counting processes for event history data, which usually exhibit under- or over-dispersion. We present some results of this process that will allow us to use it in other areas and establish both the probability mass function (pmf) and the cumulative distribution function (cdf) using transition intensities. This counting process (CP) will allow other researchers to work on modelling the CP, where data dispersion exists in an efficient and more flexible way.",book:{id:"12021",title:"Applied Probability Theory - New Perspectives, Recent Advances and Trends",coverURL:"https://cdn.intechopen.com/books/images_new/12021.jpg"},signatures:"Gerson Yahir Palomino Velandia and José Alfredo Jiménez Moscoso"},{id:"83152",title:"Recycled Synthetic Polymer-Based Electrospun Membranes for Filtering Applications",slug:"recycled-synthetic-polymer-based-electrospun-membranes-for-filtering-applications",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106683",abstract:"Synthetic polymers have been widely applied in various commercial and household applications owing to their fascinating properties of low-cost, lightweight, and processability. However, increasing population and living standards and rising demand for non-biodegradable polymers have led to the accumulation of plastic pollution resulting in the current environmental crisis. Current waste management methods such as landfilling or incineration do not solve these environmental issues. On the other hand, recycling plastic waste is the most valuable strategy for dealing with waste as raw material for high-value products. One of such products is filter membranes. Polymer fiber membranes as masks in pandemics have been one of the most sought-after products in recent years. Some types of plastic waste became a material source for the development of filter materials, which could contribute to the protection of human health. Utilizing the simple, cheap, and industrially available technological solution is also needed. Given the number of advantages, electrospinning is such a beneficial solution. The electrospun polymer waste-based membranes show excellent filtration performance and can carry many other functionalities. Therefore, this review article presents a brief overview of electrospun nanofibrous membranes based on synthetic plastic waste and summarizes the filtration performance of such membranes. This review will discuss the future perspectives of electrospun membranes as well.",book:{id:"11462",title:"Recent Developments in Nanofibers Research",coverURL:"https://cdn.intechopen.com/books/images_new/11462.jpg"},signatures:"Alena Opálková Šišková, Heba M. Abdallah, Smaher Mosad Elbayomi and Anita Eckstein Andicsová"},{id:"83166",title:"General Drag Correlations for Particle-Fluid System",slug:"general-drag-correlations-for-particle-fluid-system",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106427",abstract:"Particle-fluid flows are commonly encountered in industrial applications. It is of great importance to understand the fundamentals governing the behavior of such a flow system for better process design, control, and optimization. Generally, the particle-fluid flow behavior is strongly influenced by the interaction forces between fluid and particles. Among the various kinds of particle-fluid interaction forces, the drag force is the most essential. This chapter reviews the modeling of drag force for particle-fluid systems: from single particle to multiple particles, monosize to multisize, spherical to nonspherical, and Newtonian fluid to non-Newtonian fluid. Typical drag correlations in the literature are compared and assessed in terms of physical meaning, consistency, and generality.",book:{id:"11498",title:"Boundary Layer Flows - Modelling, Computation, and Applications of Laminar, Turbulent Incompressible and Compressible Flows",coverURL:"https://cdn.intechopen.com/books/images_new/11498.jpg"},signatures:"Zheng Qi, Shibo Kuang, Liangwan Rong, Kejun Dong and Aibing Yu"},{id:"82272",title:"Landslide Movement Monitoring with InSAR Technologies",slug:"landslide-movement-monitoring-with-insar-technologies",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105058",abstract:"Synthetic aperture radar interferometry (InSAR) is a technology that has been widely used in many areas, such as topographic mapping, land and resource survey, geological exploration, disaster prevention and mitigation, volcanic and seismic monitor and so on. Landslide, as a representative geohazard, include a wide range of phenomena involving downhill ground movement. InSAR, a technology which can measure surface deformation at the millimeter level over serveral days or years, is suitable to detect landslides with chronical and widespread movements. In this chapter, we introduce main process methods of InSAR data, including Persistent Scatter Interferometry (PSInSAR) and Distributed Scatter Interferometry (DSInSAR). A study area, Daguan County Town, one of the most landslide-prone areas in China is induced to demonstrate the practicability of InSAR in detecting landslides. Combined InSAR results with geological, geotechnical and meterological data, the distribution of landslide in Daguan County in spatial and temporal dimensions would be displayed. We also coupling numerical modeling and InSAR for characterizing landslide movements under multiple loads. 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At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. 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