Five healthy lifestyles that extend lifespan more than 10 years.
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6401",leadTitle:null,fullTitle:"Achievements and Challenges of Integrated River Basin Management",title:"Achievements and Challenges of Integrated River Basin Management",subtitle:null,reviewType:"peer-reviewed",abstract:"Integrated river basin management is an approach focusing on the development and management of land and water resources in a coordinated manner with the primary aim to ensure society development, which is well balanced from the environmental, economic, and social points of view. It is a complex approach, including all aspects of water resource management (water and aquatic ecosystem protection, disaster management, and water use) and covering a wide range of disciplines (e.g., hydrology, ecology, environmental management, and economy), cross-cutting issues (climate change, data sharing, and stakeholder involvement), and approaches (river basin management plans preparation, water-food-energy-ecosystems nexus assessment, science-policy integration, and transboundary cooperation). This book provides a comprehensive overview of achievements and challenges associated with the implementation of the approach throughout the world.",isbn:"978-1-78923-483-1",printIsbn:"978-1-78923-482-4",pdfIsbn:"978-1-83881-456-4",doi:"10.5772/intechopen.70100",price:119,priceEur:129,priceUsd:155,slug:"achievements-and-challenges-of-integrated-river-basin-management",numberOfPages:252,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a1a3b10b0841d76f15cfe65eff20e34c",bookSignature:"Dejan Komatina",publishedDate:"July 25th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6401.jpg",numberOfDownloads:13986,numberOfWosCitations:21,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:36,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:71,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 12th 2017",dateEndSecondStepPublish:"July 3rd 2017",dateEndThirdStepPublish:"September 29th 2017",dateEndFourthStepPublish:"December 28th 2017",dateEndFifthStepPublish:"February 26th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"78248",title:"Dr.",name:"Dejan",middleName:null,surname:"Komatina",slug:"dejan-komatina",fullName:"Dejan Komatina",profilePictureURL:"https://mts.intechopen.com/storage/users/78248/images/5713_n.jpg",biography:"Dejan Komatina holds a PhD in civil engineering, with a focus on environmental river engineering. He has 28 years of national and international experience in integrated water resources management and sustainable development of river basins in the fields of science, education, engineering and management. He began his career as a teacher and/or scientist at the universities of Belgrade, Delft, Hamburg and Banja Luka. He subsequently became the first CEO of the International Sava River Basin Commission, a post he held for over 11 years, being responsible for planning, coordination, direction and management of work of the organization in the areas of water management, environment protection, climate change, sustainable waterway transport and river tourism. He joined the REC in April 2017, to coordinate the implementation of the organization’s programmes and projects in a wide range of environment-related fields.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Regional Environmental Center For Central And Eastern Europe",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"850",title:"Limnology",slug:"limnology"}],chapters:[{id:"59346",title:"Seasonal Variation of the Physico-chemical Composition of Ottawa River Waters in the St. Lawrence River",doi:"10.5772/intechopen.74122",slug:"seasonal-variation-of-the-physico-chemical-composition-of-ottawa-river-waters-in-the-st-lawrence-riv",totalDownloads:932,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The goal of this study is to compare the seasonal variability of 12 physicochemical characteristics of waters in the Ottawa and St. Lawrence Rivers (SLR). Water samples were collected on board the research vessel Lampsillis in the spring (May), summer (August), and fall (October) of 2006 at four stations located downstream from the confluence of the two rivers. Temperature and total nitrogen values varied significantly for the three seasons. In contrast, seasonal values of light extinction coefficient and turbidity do not show any significant variation. The values of the other characteristics varied significantly only for one season. Comparison of these data with those measured in 1994–1996 reveals a net warming of the waters and a significant increase in nitrite-nitrate concentrations due to the increasing use of nitrogen-bearing fertilizers by farmers in Quebec. Concentrations of these two substances are higher than the limits set by the government of Quebec for water quality in rivers.",signatures:"Jean-Jacques Frenette and Ali A. Assani",downloadPdfUrl:"/chapter/pdf-download/59346",previewPdfUrl:"/chapter/pdf-preview/59346",authors:[{id:"50312",title:"Prof.",name:"Ali",surname:"Assani",slug:"ali-assani",fullName:"Ali Assani"},{id:"215888",title:"Prof.",name:"Jean-Jacques",surname:"Frenette",slug:"jean-jacques-frenette",fullName:"Jean-Jacques Frenette"}],corrections:null},{id:"60120",title:"Assessment of Heavy Metals Contamination in Groundwater: A Case Study of the South of Setif Area, East Algeria",doi:"10.5772/intechopen.75734",slug:"assessment-of-heavy-metals-contamination-in-groundwater-a-case-study-of-the-south-of-setif-area-east",totalDownloads:1994,totalCrossrefCites:5,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Heavy metals in groundwater were analyzed and their sources and impacts were identified using multivariate statistical tools and risk assessment. Three significant factors were extracted by factor analysis (FA), explaining 75.69% of total variance. These factors were in turn described by the clusters C3, C2 and C1, respectively, resulting from the cluster analysis (CA). Factor analysis and cluster analysis revealed significant anthropogenic contributions and water-rock interaction effects of the metals in groundwater. The mean values of heavy metal evaluation index (HEI) and degree of contamination (Cdeg) indices indicated that the groundwater samples were contaminated with high degree of pollution by cadmium (Cd) and lead (Pb). The hazard quotients (via ingestion) of Cd and Pb were found to be higher than the safe limits, posing threat to the consumers. However, no risk related to the dermal contact was associated with the measured metal levels.",signatures:"Lazhar Belkhiri, Ammar Tiri and Lotfi Mouni",downloadPdfUrl:"/chapter/pdf-download/60120",previewPdfUrl:"/chapter/pdf-preview/60120",authors:[{id:"214036",title:"Dr.",name:"Lazhar",surname:"Belkhiri",slug:"lazhar-belkhiri",fullName:"Lazhar Belkhiri"},{id:"214668",title:"Dr.",name:"Ammar",surname:"Tiri",slug:"ammar-tiri",fullName:"Ammar Tiri"},{id:"214669",title:"Dr.",name:"Lotfi",surname:"Mouni",slug:"lotfi-mouni",fullName:"Lotfi Mouni"}],corrections:null},{id:"60347",title:"Hydro-Geochemical Water Inputs Identification in Glacierized Basin Hydrology",doi:"10.5772/intechopen.75390",slug:"hydro-geochemical-water-inputs-identification-in-glacierized-basin-hydrology",totalDownloads:958,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Mining activities are usually placed in the upper basin regions, especially in developing countries, with economies that strongly rely on natural commodities. Although glaciers do not occupy a large area of these mountain ranges, they deliver vital water for downstream populations. This is especially relevant during drought periods, when winter precipitation is strongly diminished and ice melt becomes relevant. They are also a key resource for highland wetland ecosystems and paradoxically at the same time for the development of mega-mining projects. Regularly, for environmental impact assessments and relevant public consultations, it will be stated that water from glaciers does not constitute an important source within the basin system, even though this has not been accurately quantified. Different water sources, given by spatial, geological, and hydrological features, can be identified using a combination of ionic and isotopic information from water, thus allowing to establish their proportions downstream, where water from different origins is mixed, and also to track their evolution over seasons. This approach should be useful especially for basins with strong pressures for the exploitation and consumption of water in mountainous basins and also with special relevance for basins with little or no knowledge of their water system and reservoirs.",signatures:"Sebastián Andrés Crespo, Francisco Javier Fernandoy and Ariel\nAndrés Muñoz",downloadPdfUrl:"/chapter/pdf-download/60347",previewPdfUrl:"/chapter/pdf-preview/60347",authors:[{id:"215959",title:"Dr.",name:null,surname:"Crespo",slug:"crespo",fullName:"Crespo"},{id:"262964",title:"Dr.",name:"Francisco",surname:"Fernandoy",slug:"francisco-fernandoy",fullName:"Francisco Fernandoy"},{id:"262965",title:"Dr.",name:"Ariel",surname:"Munoz",slug:"ariel-munoz",fullName:"Ariel Munoz"}],corrections:null},{id:"61959",title:"Basin Scale Performance of a Distributed Rainfall-Runoff Model Using Uncertainty Modelling Approach in Data Scarce Region",doi:"10.5772/intechopen.78539",slug:"basin-scale-performance-of-a-distributed-rainfall-runoff-model-using-uncertainty-modelling-approach-",totalDownloads:864,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Lack of hydrological information of the most basins in Tanzania increase uncertainties in understanding hydrological processes in the basin, and consequently leads to risks decision making related to significant water resources development plans and climate change adaptation. The lack of hydrological information also is coupled with uncertainty related to the predictions of future climate and land use change. Some of the gaps can be filled using rainfall-runoff modeling, which results can be used to generate reliable information to enable decision making and planning for water resources management. This paper discusses the results of applying a semi-distributed rainfall-runoff model which was established for the Little Ruaha Sub-Basin, using the available historical data, with a goal of understanding processes of runoff generation and the inherent uncertainty related to data. Issues of water resources assessment in the basin and approaches used to address them, and some directions for future research are discussed. There are challenges associated with the quality of data for model set-up and understanding of the model structure. Despite these challenges, there remain many opportunities to improve the methods used for water resources assessment and management within the basin.",signatures:"Madaka Harold Tumbo",downloadPdfUrl:"/chapter/pdf-download/61959",previewPdfUrl:"/chapter/pdf-preview/61959",authors:[{id:"189705",title:"Dr.",name:"Madaka",surname:"Tumbo",slug:"madaka-tumbo",fullName:"Madaka Tumbo"}],corrections:null},{id:"59715",title:"Historical, Hydrological and Hydraulics Studies for Sustainable Flood Management",doi:"10.5772/intechopen.74432",slug:"historical-hydrological-and-hydraulics-studies-for-sustainable-flood-management",totalDownloads:1036,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Extreme events such as floods can endanger human lives and cause large economic damage. The Savinja River catchment is one of the most frequently flooded areas in Slovenia, Europe. In order to evaluate the impact of the proposed flood mitigation measures on the flood safety in this catchment, the combined hydrological and hydraulic modelling approach was carried out. The hydrological model Hydrologiska Byråns Vattenbalansavdelning (HBV-light) was used to perform hydrological modelling. The hydraulic calculations were carried out using the HEC-RAS 5.0.3 model in order to simulate the combined one- and two-dimensional unsteady flow. Using the calibrated and validated hydrological and hydraulic models, the impact of the proposed measures was assessed in the light of the sustainable flood management. Additionally, with analyses of the historical data and past flood events, we were able to investigate the characteristics of the extreme floods in this area and also downstream at the confluence with the Sava River. Moreover, it was found that the backwater effect has an important role on the water level and flood safety along the river reach, which is often neglected in the aspect of flood management.",signatures:"Mitja Brilly, Andrej Kryžanowski, Mojca Šraj, Nejc Bezak, Klaudija\nSapač, Andrej Vidmar and Simon Rusjan",downloadPdfUrl:"/chapter/pdf-download/59715",previewPdfUrl:"/chapter/pdf-preview/59715",authors:[{id:"202693",title:"Prof.",name:"Mitja",surname:"Brilly",slug:"mitja-brilly",fullName:"Mitja Brilly"},{id:"206202",title:"Dr.",name:"Nejc",surname:"Bezak",slug:"nejc-bezak",fullName:"Nejc Bezak"},{id:"206206",title:"Prof.",name:"Mojca",surname:"Šraj",slug:"mojca-sraj",fullName:"Mojca Šraj"},{id:"216340",title:"Prof.",name:"Andrej",surname:"Kryžanowski",slug:"andrej-kryzanowski",fullName:"Andrej Kryžanowski"},{id:"216341",title:"Ms.",name:"Klaudija",surname:"Sapač",slug:"klaudija-sapac",fullName:"Klaudija Sapač"},{id:"222139",title:"Prof.",name:"Simon",surname:"Rusjan",slug:"simon-rusjan",fullName:"Simon Rusjan"},{id:"222140",title:"MSc.",name:"Andrej",surname:"Vidmar",slug:"andrej-vidmar",fullName:"Andrej Vidmar"}],corrections:null},{id:"60348",title:"Engagement of Local Heroes in Managing Flood Disaster: Lessons Learnt from the 2014 Flood of Kemaman, Terengganu, Malaysia",doi:"10.5772/intechopen.74262",slug:"engagement-of-local-heroes-in-managing-flood-disaster-lessons-learnt-from-the-2014-flood-of-kemaman-",totalDownloads:989,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"There were many lessons learned by the flood disaster that hit the peninsular of Malaysia at the end of 2014. Of particular interest was the success story of good flood management that emerged in Kemaman, Terengganu. This chapter sheds some light on the characteristics that contributed to this success. To enable appreciation of this achievement, a comparison between selected flood-inflicted areas is presented, pointing out the similarity between flood factors that, however, produced differences in flood impact. A post-disaster study, which included analysis of flood reports, site visits (which included the disaster site, flood command centre and relief centres) and interviews with those involved in the flood incident, was conducted. The findings revealed the use of technology, a good standard operating procedure and engagement of the local community to be key ingredients of its successful outcome. The study recommends the success of Kemaman to inspire flood management practice for other non-urban flood districts in Malaysia.",signatures:"Marini Othman, Aliza Abdul Latif, Siti Sarah Maidin, Mohamad\nFirdaus Mat Saad and Mohammad Nazir Ahmad",downloadPdfUrl:"/chapter/pdf-download/60348",previewPdfUrl:"/chapter/pdf-preview/60348",authors:[{id:"216901",title:"Ms.",name:"Aliza",surname:"Abdul Latif",slug:"aliza-abdul-latif",fullName:"Aliza Abdul Latif"},{id:"216902",title:"Dr.",name:"Marini",surname:"Othman",slug:"marini-othman",fullName:"Marini Othman"},{id:"223531",title:"Dr.",name:"Siti Sarah",surname:"Maidin",slug:"siti-sarah-maidin",fullName:"Siti Sarah Maidin"},{id:"223535",title:"Mr.",name:"Mohamad Firdaus",surname:"Mat Saat",slug:"mohamad-firdaus-mat-saat",fullName:"Mohamad Firdaus Mat Saat"},{id:"223542",title:"Dr.",name:"Mohammad Nazir",surname:"Ahmad",slug:"mohammad-nazir-ahmad",fullName:"Mohammad Nazir Ahmad"}],corrections:null},{id:"58852",title:"Sustainable Groundwater Management in Context of Climate Change in Northwest Bangladesh",doi:"10.5772/intechopen.73305",slug:"sustainable-groundwater-management-in-context-of-climate-change-in-northwest-bangladesh",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The objectives of the study are to understand the variability and changes in hydro-climatic variables in space and time dimensions, and to evaluate the performance of managed aquifer recharge (MAR) for sustainable water resources management in northwest Bangladesh. The study reveals that groundwater resource in the northwest Bangladesh is under stress. The stress has developed and it increases over the years, as a result, shallow groundwater resource has already become scarce. The people of the area are not getting even drinking water using their hand tube wells (HTWs) during the dry season and facing trouble with irrigation water. These problems are becoming acute as a result of uncontrolled and unplanned groundwater abstraction for irrigation. Moreover, rainfall in the study area decreases and dryness increases. Higher values of the seasonality index (\n\n\nSI\n¯\n\n=\n0.87\n\n) and precipitation concentration index (PCI = 19.8) are indicators of frequent dry spells. The area suffered from 12 moderate-extreme droughts during 1971–2011, and moderate to high drought risk (B) prevails in the area. The frequent drought, decreasing trend in rainfall, transboundary river flow, and thick clay surface lithology along with the uncontrolled irrigation are also responsible for rapid depletion of groundwater. As the annual surplus of water (average = 594 mm) is higher than groundwater recharge (330 mm), an experimental study on managed aquifer recharge (MAR) has been conducted to enhance the groundwater recharge. It shows good performance for restoring the groundwater without creating any sorts of hazards. Moreover, almost 5% of irrigated land can be irrigated from surface water sources by re-excavating the rivers, Kharis (small channels). It is necessary to prepare an integrated water resource management plan (IWRMP) considering the impacts of climate change, drought risk, driving factors of the groundwater resource depletion, and rainwater as a resource for achieving the sustainability.",signatures:"A.T.M. Sakiur Rahman, Takahiro Hosono, Quamrul H. Mazumder\nand Chowdhury S. Jahan",downloadPdfUrl:"/chapter/pdf-download/58852",previewPdfUrl:"/chapter/pdf-preview/58852",authors:[{id:"191069",title:"Prof.",name:"Chowdhury Sarwar",surname:"Jahan",slug:"chowdhury-sarwar-jahan",fullName:"Chowdhury Sarwar Jahan"},{id:"214531",title:"Mr.",name:"A T M Sakiur",surname:"Rahman",slug:"a-t-m-sakiur-rahman",fullName:"A T M Sakiur Rahman"},{id:"214533",title:"Prof.",name:"Quamrul Hasan",surname:"Mazumder",slug:"quamrul-hasan-mazumder",fullName:"Quamrul Hasan Mazumder"},{id:"231017",title:"Dr.",name:"Takahiro",surname:"Hosono",slug:"takahiro-hosono",fullName:"Takahiro Hosono"}],corrections:null},{id:"59001",title:"Transboundary Cooperation and Sustainable Development in the Rhine Basin",doi:"10.5772/intechopen.73260",slug:"transboundary-cooperation-and-sustainable-development-in-the-rhine-basin",totalDownloads:1267,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"The Rhine connects millions of people from the Alps to the North Sea. With a length of 1233 km, its catchment includes nine states, an area of about 200,000 km2, 60 million inhabitants as well as important cities and fascinating landscapes. Consequently, the Rhine is culturally, historically and economically one of the most important rivers in Europe. The International Commission for the Protection of the Rhine (ICPR) was founded in 1950 with the first common goal in history to reduce water pollution. The whole process got a new impetus with the chemical catastrophe at the Sandoz plant (near Basel) in 1986, which saw aquatic ecosystems being seriously damaged. This disaster led to a better integration of the issue of ecology into the tasks of the ICPR. Depollution and rehabilitation programmes with actions and measures were established. In the 1990s, severe flood events forced the ICPR to add flood prevention to its sustainability goals enabling a better protection of citizens. This chapter presents the common work of the countries aimed at protecting the Rhine basin and the most important environmental outcomes of this special and long-lasting partnership.",signatures:"Anne Schulte-Wülwer-Leidig, Laura Gangi, Tabea Stötter, Marc\nBraun and Adrian Schmid-Breton",downloadPdfUrl:"/chapter/pdf-download/59001",previewPdfUrl:"/chapter/pdf-preview/59001",authors:[{id:"215189",title:"Mr.",name:"Adrian",surname:"Schmid-Breton",slug:"adrian-schmid-breton",fullName:"Adrian Schmid-Breton"},{id:"224222",title:"Dr.",name:"Anne",surname:"Schulte-Wülwer-Leidig",slug:"anne-schulte-wulwer-leidig",fullName:"Anne Schulte-Wülwer-Leidig"},{id:"224223",title:"Dr.",name:"Laura",surname:"Gangi",slug:"laura-gangi",fullName:"Laura Gangi"},{id:"224225",title:"Dr.",name:"Marc",surname:"Braun",slug:"marc-braun",fullName:"Marc Braun"},{id:"224227",title:"Dr.",name:"Tabea",surname:"Stötter",slug:"tabea-stotter",fullName:"Tabea Stötter"}],corrections:null},{id:"60069",title:"Monitoring of Meteorological, Hydrological Conditions and Water Quality of the Main Tributaries of the Transboundary Amu Darya River",doi:"10.5772/intechopen.74958",slug:"monitoring-of-meteorological-hydrological-conditions-and-water-quality-of-the-main-tributaries-of-th",totalDownloads:1194,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"The results of monitoring of meteorological, hydrological parameters and hydrochemistry of the main tributaries of the transboundary Amu Darya River, the Vakhsh, Zeravshan and Pyanj rivers are presented. The influence of climate change on the meteorological characteristics of river basins has been observed. The need for coordination of Central Asian countries in the implementation of integrated water resources management is suggested. It is pointed out that the lack of a developed network of hydrometeorological observation points and a low level of information exchange among the countries of the region often leads to the emergence of scientifically unjustified scenarios and forecasts of climatic and hydrological processes in the region. The creation of a single regional center for cryosphere and hydrometeorological observations for continuous monitoring of processes occurring with water objects in the region is proposed.",signatures:"Parviz I. Normatov and Inom Sh. Normatov",downloadPdfUrl:"/chapter/pdf-download/60069",previewPdfUrl:"/chapter/pdf-preview/60069",authors:[{id:"214149",title:"Prof.",name:"Inom",surname:"Normatov",slug:"inom-normatov",fullName:"Inom Normatov"},{id:"214152",title:"Dr.",name:"Parviz",surname:"Normatov",slug:"parviz-normatov",fullName:"Parviz Normatov"}],corrections:null},{id:"59624",title:"Information-Communication Technologies as an Integrated Water Resources Management (IWRM) Tool for Sustainable Development",doi:"10.5772/intechopen.74700",slug:"information-communication-technologies-as-an-integrated-water-resources-management-iwrm-tool-for-sus",totalDownloads:1350,totalCrossrefCites:1,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Sustainability is a crucial and at the same time vital approach for satisfying future generations’ rights on natural resources. Toward this direction, global policies, supported by international organizations such as UNESCO and its international science programs, foster sustainable development as principal concept for the management of various thematic areas including the environment. The present work promotes the integration of information-communication technologies (ICTs) in the water resources management field as a state of the art concept that sets the basis for sustainable development at global scale. The research focuses on the ICTs contribution to the evolution of scientific and technological disciplines, such as satellite earth observations, real time monitoring networks, geographic information systems, and cloud-based geo information systems and their interconnection to integrated water resources management. Moreover, selected international research programs and activities of UNESCO International Hydrology Programme (IHP) are synoptically but comprehensively being presented to demonstrate the integration of the technological advances in water resources management and their role toward sustainable development.",signatures:"Charalampos Skoulikaris, Youssef Filali-Meknassi, Alice Aureli, Abou\nAmani and Blanca Elena Jiménez-Cisneros",downloadPdfUrl:"/chapter/pdf-download/59624",previewPdfUrl:"/chapter/pdf-preview/59624",authors:[{id:"216491",title:"Dr.",name:"Charalampos",surname:"Skoulikaris",slug:"charalampos-skoulikaris",fullName:"Charalampos Skoulikaris"}],corrections:null},{id:"59288",title:"Communities at the Centre of River Basin Management for Sustainable Development in Northwest Cameroon",doi:"10.5772/intechopen.74119",slug:"communities-at-the-centre-of-river-basin-management-for-sustainable-development-in-northwest-cameroo",totalDownloads:1063,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Access to a reliable water resource can be a key driver for socio-economic development. Both physical and economic water scarcities are negatively affecting the economies of sub-Saharan African countries, particularly rural communities with the latter considered a crucial challenge. This paper examines the role of local resource users in river basin management for sustainable development in Northwest Cameroon. Using secondary data and empirical evidence collected from three rural districts (Mbengwi, Njinikom, and Ndu) in Northwest Cameroon, it is argued that the involvement and engagement of local resource users and community-based organisations in decision-making processes in river basin management can contribute to sustainable water supplies and enhance sustainable development. In the context of rural communities in the Northwestern part of Cameroon where water supply is mostly through gravity-led techniques, river basins are the main sources of community water supply. It is, therefore, argued in this paper that sustainable development will be possible through a polycentric water governance approach. Thus, clarifying issues of participation, integration, and jurisdiction between the stakeholders (central and local governments and community groups) is crucial for sustainable outcomes. Until the full participation and engagement of local groups and resource users in decision-making processes are achieved, uncertainty will dominate river basin management in Northwest Cameroon.",signatures:"Henry Bikwibili Tantoh, Danny Simatele, Eromose Ebhuoma and\nFelix Kwabena Donkor",downloadPdfUrl:"/chapter/pdf-download/59288",previewPdfUrl:"/chapter/pdf-preview/59288",authors:[{id:"223789",title:"Dr.",name:"Henry",surname:"Tantoh",slug:"henry-tantoh",fullName:"Henry Tantoh"},{id:"223793",title:"Prof.",name:"Danny",surname:"Simatele",slug:"danny-simatele",fullName:"Danny Simatele"},{id:"223794",title:"MSc.",name:"Eromose",surname:"Ebhuoma",slug:"eromose-ebhuoma",fullName:"Eromose Ebhuoma"},{id:"223797",title:"MSc.",name:"Felix",surname:"Kwabena Donkor",slug:"felix-kwabena-donkor",fullName:"Felix Kwabena Donkor"}],corrections:null},{id:"59604",title:"Strengths and Weaknesses for Climate Change: Adaptation in Water Governance: A Comparison Across Six European Regions",doi:"10.5772/intechopen.74401",slug:"strengths-and-weaknesses-for-climate-change-adaptation-in-water-governance-a-comparison-across-six-e",totalDownloads:1008,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"This chapter comparatively analyses the policy and governance contexts of six European regions that are affected by different hydrological impacts of climate change. The results demonstrate that a major governance strength across regions lies in the organization of management capacities to deal with existing water-related risks. For example, the Dutch context focuses on water safety, Cyprus has a clear policy framework to deal with water scarcity and in the Norwegian city of Bergen, wastewater is well managed. As a consequence of this focus on present-day risks, climate adaptation governance also focuses on historical risks. New or exacerbated risks posed by climate change remain largely untreated, and responsibilities for dealing with climate-related risks remain unspecified, as also becomes clear in the German and Spanish cases. A high degree of governmental fragmentation is identified as another point of weakness. Identified most clearly in the Portuguese case but recognizable in all regional contexts, different subdomains of water management are dealt with under separate policies and are governed by different responsible agencies. Consequently, information about current performance of the water system is scattered and coordinative efforts, which are key to developing adaptation strategies, are hampered.",signatures:"Emmy Bergsma, H. Van Alphen, A. Bruggeman, E. Giannakis, J. Koti,\nE. Kristvik, P. Loza, M. Martinez, T.M. Muthanna, F. Rocha, T. Viseu\nand C. Zoumides",downloadPdfUrl:"/chapter/pdf-download/59604",previewPdfUrl:"/chapter/pdf-preview/59604",authors:[{id:"218864",title:"Dr.",name:"Emmy",surname:"Bergsma",slug:"emmy-bergsma",fullName:"Emmy Bergsma"},{id:"220078",title:"MSc.",name:"Henk-Jan",surname:"Van Alphen",slug:"henk-jan-van-alphen",fullName:"Henk-Jan Van Alphen"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5282",title:"Lake Sciences and Climate Change",subtitle:null,isOpenForSubmission:!1,hash:"34ba6ce6df0e6f5c99263d7d80907861",slug:"lake-sciences-and-climate-change",bookSignature:"M.Nageeb Rashed",coverURL:"https://cdn.intechopen.com/books/images_new/5282.jpg",editedByType:"Edited by",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6888",title:"Limnology",subtitle:"Some New Aspects of Inland Water Ecology",isOpenForSubmission:!1,hash:"7d42cb45185f853324e60b7284c7ea96",slug:"limnology-some-new-aspects-of-inland-water-ecology",bookSignature:"Didem Gökçe",coverURL:"https://cdn.intechopen.com/books/images_new/6888.jpg",editedByType:"Edited by",editors:[{id:"178260",title:"Associate Prof.",name:"Didem",surname:"Gokce",slug:"didem-gokce",fullName:"Didem Gokce"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9660",title:"Inland Waters",subtitle:"Dynamics and Ecology",isOpenForSubmission:!1,hash:"975c26819ceb11a926793bc2adc62bd6",slug:"inland-waters-dynamics-and-ecology",bookSignature:"Adam Devlin, Jiayi Pan and Mohammad Manjur Shah",coverURL:"https://cdn.intechopen.com/books/images_new/9660.jpg",editedByType:"Edited by",editors:[{id:"280757",title:"Dr.",name:"Adam",surname:"Devlin",slug:"adam-devlin",fullName:"Adam Devlin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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\r\n\tThis book will explore how gender and sexual minorities have created communities of meaning and political expression around the world. Through a series of case studies, historical considerations, and reflections, different communities of gender and sexual minority groups will be explored. The book will give an overview of the wide variety of experiences that people who identify as gender and sexual minority group members have used in the formation of community, both online and in person. We will see that some of these creations of the community are a reaction to the exclusion by the larger society in which members are embedded. We will also see that people create a community in the face of oppression, engage in dialogue and activities (political and social), and create meaning in their identities. We will witness how these spaces give voice to change, resilience, and survival. For all of us who are queer and trans, community means at a minimum the place in which we can thrive and be seen.
",isbn:"978-1-83969-612-1",printIsbn:"978-1-83969-611-4",pdfIsbn:"978-1-83969-613-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"e08bb222c250dcebf093b7ab595a14a7",bookSignature:"Dr. Deborah Woodman",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11777.jpg",keywords:"Lesbian, Gay, Bisexual, Trans, Queer, Online Communities, Rural Communities, Historical Communities, Rural Communities, Urban Communities, Political Communities, Identity Based",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 27th 2022",dateEndSecondStepPublish:"June 30th 2022",dateEndThirdStepPublish:"August 29th 2022",dateEndFourthStepPublish:"November 17th 2022",dateEndFifthStepPublish:"January 16th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"An active member of the queer community in Sault Ste. 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This publication brings her interests together by combining her doctoral work on rural communities with her advocacy work with Queer and Trans folk.",institutionString:"Algoma University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Algoma University",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"21",title:"Psychology",slug:"psychology"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453622",firstName:"Tea",lastName:"Jurcic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"tea@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6494",title:"Behavior Analysis",subtitle:null,isOpenForSubmission:!1,hash:"72a81a7163705b2765f9eb0b21dec70e",slug:"behavior-analysis",bookSignature:"Huei-Tse Hou and Carolyn S. 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It is logistically harder to test this in longer living animals due to the length of studies needed, but there are studies in non-human primates [1] and ongoing human test groups who show fewer signs of cardiovascular aging [2]. Two trials calorically constricting macaques began in the 1980s and initially had conflicting results. A study out of University of Wisconsin found a drastic 30% increased survival in the CR group compared to control [3], while a latter study by the National Institute on aging (NIA) did not find a statistically relevant effect [4]. It was later found that in the NIA study, control monkeys consumed fewer calories than expected, and some in the CR groups began consuming reduced calories as juveniles, which is known to reduce lifespan. A reanalysis of all data by both groups agreed caloric restriction appears to increase macaque longevity by almost 10% (3 years in macaques which would translate to 9 years in humans) [1].
\nIn general results have seemed positive, extending life, but to a lesser degree than in small animal models, such as mice which have seen up to a 50% increase in lifespan from CR [5]. The search for pharmaceuticals to mimic CR life extension will need to continue the long and expensive process of large human studies due to humans’ unique interaction with calories in our post-industrial world. Study designs for larger caloric restriction studies are often questioned. Particularly concerning humans, the ability to accurately track caloric consumption in people living outside a clinical setting has often relied on caloric approximations such as food diaries, pictures of food eaten [6, 7, 8], or dietary consumption habits at a national level when comparing between countries. The larger percentage life extension effects from CR has been seen across many simpler organisms with budding yeast, fruit flies and worms having their lifespan increased 2–3 fold. However, no mammals have had such large effects. Indeed no one has suggested humans could achieve such great gains with CR which would extend our current upper lifespan from ~100 years to over 200 years. However, mammals such as rats and mice have shown a 20–50% reduction in calories can result in a lifespan increase of up to 50% [9, 10].
\nEven with these qualifiers in mind, it seems likely that a 30–60% reduction in calories could extend human life 10–20%. This gain of ~1% of lifetime for every ~3% reduction in calories translates to a likely ~10–20 years of extra life for humans, which is similar to the 9-year human equivalent life extension seen in the recent reanalysis of primates undergoing CR [1]. This 1:3 ratio of %lifetimeExtension:%caloricRestriction (LE:CR) may end up being 1:4 or 1:2 in humans, but in either scenario it is most likely caloric restriction will show a statistically significant life extension in humans. However, it is not likely to be a panacea that would give us 50 extra years bringing us past 150 years-of-age, despite that relative effect in mice.
\nThe current dilemma has been elucidating the root cause(s) responsible for life extension which are being targeted as pharmaceutical targets. The “inputs” that one might measure which lead to an increased lifespan in humans (e.g. obesity, cholesterol, cancer, bone density) are numerous and often orthogonal in nature. For example at pharmacological concentrations resveratrol does inhibit obesity but did not inhibit cellular senescence like rapamycin does [11]. While resveratrol and rapamycin were at times thought to act similarly, their mechanistic and pharmacological issues are diverging. While resveratrol had been found to extend life in studies there have been negative results with some labs failing to find life extension in all strains of yeast [12], worms, and flies [13]. Indeed rapamycin but not resveratrol has been shown to extend lifespan in mice [14]. Resveratrol may increase our quality of life while rapamycin (and rapalogs) could increase our quantity of life. In addition, one of resveratrol’s main issues is its bioavailability (it’s good we just want more), whereas rapamycin may shut down people’s immune system too much leading to cancer (it’s good but too much is bad). The mechanism of action for rapamycin, resveratrol, and metformin, as well as animal and human studies will be discussed.
\nThe ideal “biological scale” at which aging can be targeted is also still in question (a single gene, pathway, salvaging a cell, or killing unrecoverable cells) (Figure 1). Single genes continue to be investigated with inhibition by siRNA, conditional knockouts, or reducing posttranslational modifications such as lipid anchoring [15, 16, 17, 18, 19, 20, 21], while activation could be investigated via upregulation of transcription factors or viral therapy such as CRISPR. However, due to overlapping inputs the field often addresses how entire pathways are being affected (such as increased mitochondria biogenesis by caloric restriction). In addition while in vitro studies have often looked at modifying a cells genetic profile to have more of a centenarian profile (i.e. to rescue human cells via an intervention), it has recently been shown many cells become senescent and causing those to undergo apoptosis can save other cells thereby resulting in organism longevity [22, 23, 24, 25, 26, 27, 28]. The easiest abnormal aging targets may be the overactive cancerous cells we have become use to targeting via single genetic markers (e.g. targeting estrogen receptor sensitivity in breast cancer). Pathways can be targeted via some important individual targets, for example rescuing p53 deficiency or inhibiting mdm2 over activity to cause apoptosis. However rescuing cells from becoming senescent is the hardest and most distant task, required to truly push human longevity beyond a ~125 year limit (Figure 1). An important comparison is the case of the hydra which has been pointed to in the last couple of decades as an immortal multicellular organism [29, 30]. The hydra however, has a structure in which stem cells continually differentiate and move the periphery where they fluff off. There is not a large repository of persistent differentiated cells that can never become senescent for their hydra to continue living. In this regard the hydra can be thought of amputating any problem cells which it can replace [31, 32, 33]. Many of humanity’s growing diseases involve multi-organ systems with terminally differentiated cells which cannot be easily replaced. For example, neurodegenerative diseases such as Alzheimer disease (AD) have phenotypic effects when neurons start dying in large numbers. While CR and CR mimics may increase autophagy and delay cell death, as discussed below, there is not evidence that inhibition of the mTOR pathway can perpetually shift humans as an organism to a hydra like state of immortality. Since 1932 the correlation between mass and metabolic rate for mammals has been investigated as a foundation for humans’ upper lifespan limit [34, 35]. It could be that the lower molecular activity from CR will shift humans to a longer lifespan following the three-quarters power law (or Kleiber’s Law), although more recent studies seem to be elucidating cellular and molecular minutia in a more fine-grained manner than Kleiber’s course mass does [36, 37, 38].
\nTherapeutics for “aging” will likely having differing levels of complexity in their targets depending on if they are targeting a single gene (easiest), a pathway, cause death of senescent cells, or trying to salvage a cell from becoming senescent (most difficult). Overactive cancerous cells can be targeted simply to kill based on one receptor or gene, while salvaging neurons from death (e.g. various dementias) is a harder therapeutic task.
A wealth of studies has confirmed that rapamycin and rapalogs directly inhibit mTOR, whereas resveratrol’s targets are more numerous. Initially resveratrol was thought to act primarily through activation of sirtuins, with sirtuin-1 (SIRT1) known to help reduce obesity [39]. It is now known resveratrol also activates adenylyl cyclase and AMP-activated protein kinase (AMPK), while inhibiting a slew of proteins including lipoxygenase, protein kinase C (PKC), p53, mitogen-activated protein kinase 3 (MAPK3), proto-oncogene tyrosine-protein kinase (Src), signal transducer and activator of transcription 3 (STAT3), and IκB alpha kinase (IKK) [40]. One of the main targets is now AMPK activation which itself activates SIRT1 leading to mTOR inhibition.
\nAMPK is one of the primary metabolic detectors conserved across genera being activated by conditions that cause a low ATP:ADP ratio such as hypoglycemia and hypoxia. Phosphorylation of likely over 1000 targets by AMPK [41] shuts off anabolic pathways (energy-using) and turns on catabolic pathways (energy-generating). One of AMPKs targets for phosphorylation is peroxisome proliferators-activated receptor gamma coactivator-1 alpha (PGC-1α) which becomes active resulting in increased mitochondria biogenesis, membrane potential, and fatty acid oxidation [42], a recurring feature found during caloric restriction [43, 44]. AMPK also activates forkhead transcription factors of the O class (FOXO) which leads to increased autophagy and antioxidants, both leading to increased oxidative metabolism, like PGC-1α does [44].
\nIn the case of life extending interventions dosing becomes very important. Too much of a good thing, can definitely be bad (i.e. cancer), and the molecular mechanism effecting longevity are being elucidated. For example, in
Metformin is a third life extending compound worth contrasting to rapamycin and resveratrol because it inhibits the mitochondrial respiratory chain complex I, leading to decreased ATP:ADP, which activates AMPK [56]. In addition metformin has lots of human data since it is a common oral antidiabetic drug used for overweight people with type 2 diabetes mellitus (T2DM). Metformin inhibits hepatic glucose production, reduces insulin resistance, and has recently been investigated as anti-aging therapeutic. Metformin is currently being investigated for use in various cancers [57, 58]; however, metformin has also been linked to the development of some solid tumors in humans, namely colorectal, breast, and pancreas cancer [59]. Mitochondrial complex I is clearly inhibited by metformin leading to the AMPK dependent activation of TSC2 which inhibits mTOR. AMPK can also directly inactivate mTORC1 complex via phosphorylation of its subunit Raptor. However, it has also been shown that metformin can act in an AMPK independent manner, though that mechanism is less clear but could involve nuclear pore complex (NPC) or late endosome interactions which have been documented [46]. The NPC interaction was found when
While gross metrics such as weight are often reported in studies and useful to follow, they are not sufficient to investigate the aging phenomenon. For example, mice administered resveratrol have been found to not lose weight [65, 66]. The degree to which resveratrol mimics caloric restriction (CR) has been shown at a molecular level in mice with changes in gene expression overlapping in the adipose tissue, skeletal muscle, heart, liver, and neocortex. Interestingly, both resveratrol and CR slowed age-related decline in organ function, showing the benefit from resveratrol was not dependent on weight loss [65, 66]. The other side of the caloric coin which is frequently investigated independently of CR is exercise induced caloric deficit. In general CR has more robust life extension properties than an exercise induced caloric deficit. For modern humans it is clear it is extremely difficult to exercise one’s way into the same caloric deficit that can be attained through CR. In short, it is harder to run off a fast food meal than to not have the meal in the first place. It has been shown in rodents that increased activity to achieve a 30% relative energy deficit did not extend maximal lifespan but did increase average lifespan [9, 67]. The ability of resveratrol to increase lifespan has varied significantly between studies, but been roughly 40% for yeast, 15% for worms, 30% for fish, and 10% for mice [68].
\nThere are two mTOR multisubunit protein complexes which have been shown to be differentially regulated. mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) share the protein components DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8, also known as GβL), telomere maintenance 2 (telO2), and telO2-Interacting Protein 1 (tti1) (shown as light blue in Figure 2). mTORC1 has three core components: mTOR, regulatory-associated protein of mTOR (Raptor), and mammalian lethal with sec-13 protein 8 (mLST8). Whereas mTOR complex 2 (mTORC2) core components share mTOR, mLST8, but also include rapamycin-insensitive companion of TOR (Rictor), and mammalian stress-activated map kinase-interacting protein 1 (mSIN1) (Figure 2) [69]. mTORC1 is activated by nutrients and growth factors while being inhibited in low energy cellular states. A known complexity with the mTOR pathway is the difference in response to inhibitors, not only by mTORC1 and mTORC2, but also by tissue. mTORC1 is universally inhibited by rapamycin, whereas mTORC2 needs long term exposure to be inhibited by rapamycin which continues to be investigated. While DEPTOR is known to partially inhibit mTORC1 it may not decrease lipogenesis or inflammation alone, however in conjunction with AKT Serine/Threonine Kinase 1 (AKT) inhibitors can result in both decreases in lipogenesis and inflammation [70]. Combination therapy may be necessary in targeting mTORC1 to attained desired effects.
\nmTORC components, signaling, and inhibitors. Food, old age, and cancer activate PI3K and inactivation of AMPK which cause an increase mTOR activity in both complexes mTORC1 and mTORC2 and decrease the level of cellular autophagy. Autophagy can be restored through mTOR inhibitors (rapalogs, ATP-competitive inhibitors, Pan-mTOR inhibitors, dual PI3K/mTOR inhibitors) or reduced caloric intake (growth signals)‑all restore autophagy. Beneficial and deleterious interactions or macromolecules are shown in green and or dashed red respectively. Proteins found in both mTOR1 and mTOR2 are colored blue.
While multiple targets upstream of mTOR continue to be investigated, well described downstream actions of mTOR help in analysis of in vivo, in vitro, and clinical studies. While the major downstream effect of mTOR activation is anabolic energy production (with inhibitors shifting to catabolic energy production from fat), another significant downstream effect of mTOR activation is increased inflammation. In general people living in the western world live in a state of excess inflammation. Time restricted feeding (TRF) was found to help immune response, reducing systemic low-grade inflammation and age-related chronic diseases linked to immunosenescence, without compromising muscle performance [71]. The reduced inflammation seen in calorically restricted individuals is partially due to an increase in autophagy from CR (see below). The mTOR pathway has been shown to trigger the development of T cells, B cells, and antigen-presenting cells (APC). Indeed resveratrol (found in plants such as grapes, red wine, mulberries, and peanuts) has been described as a broad spectrum of action anti-inflammatory which attenuates microglial cell overactivation through mTOR inhibition [72]. Resveratrol inhibition of NF-κB causes an increase in superoxide dismutase (SOD) and results in decreased proinflammatory cytokines IL-1β, IL-6, and TNF-α [73, 74, 75, 76].
\nGenome wide analysis will likely be needed to elucidate the beneficial molecular level causes of caloric restriction. For example, Dato et al. recently analyzed pathway-based SNP-SNP interactions of 3 pathways: the insulin/insulin-like growth factor signaling (IIS), DNA repair, and pro/antioxidants. Synergistic effects on longevity were found in the combination of growth hormone secretagogue receptor (GHSR) and double strand break repair nuclease MRE11 homolog (MRE11A) genes which are involved in IIS signaling. TP53 also had synergistic effects with either ERCC Excision Repair 2 (ERCC2) or thioredoxin reductase 1 (TXNRD1). Those results highlighted the central role of TP53 in activating DNA repair and pro-antioxidant pathways [77].
\nOne pathway difference between rapamycin and resveratrol is the large magnitude with which rapamycin increases autophagy over apoptosis, which helps in regards to life extension but could prove problematic in cancer use. Pharmacological levels of resveratrol on the other hand prevent upregulation of Akt activation and autophagy thereby causing apoptosis. Resveratrol does inhibit obesity at pharmacological concentrations, prevent heightened hyperinsulinemia, or inhibit mTOR in vitro and therefore did not inhibit cellular senescence like rapamycin does [11]. Large levels of resveratrol have recently been shown to induce autophagy when inhibiting mTOR directly through ATP competition [78]. Combination therapy of rapamycin and resveratrol has proven synergistic in treatment of breast cancer cells [79, 80].
\nCaloric restriction has been shown to increase autophagy through inhibition of mTOR and delay molecular events associated with dementia. The rise in neurodegenerative diseases, which are exacerbated by low autophagy levels, heightens interest in mTOR inhibitors. Caloric restriction achieves mTOR inhibition through two pathways: decreased PI3K activity and increased AMPK activity (Figure 2). Cells in low energy states (calorically restricted) have low PI3K activity, lowering Akt activity, which then lowers mTORC1 via inhibition by Tsc1/2 (Figure 3). Rapamycin directly inhibits mTOR but metformin and resveratrol inhibit mTOR through upstream pathways, inhibiting the mitochondrial complex I activity and increasing AMPK respectively. In the well fed state mTORC1 inhibits autophagy via inhibition of SIRT1, Unc-51 like autophagy activating kinase (ULK1), transcription factor EB/E3 (TFEB/TFE3). Active mTOR also stimulates eukaryotic translation though phosphorylation and inhibition of 4E-BP1 which in turn releases the bound cap-binding eukaryotic translation initiation factor 4E (eif-4E). When eif-4E is released it can participate in forming the eIF4F complex required for initiation of cap-dependent translation. Ribosomal proteins S6 and S6K are also stimulated by mTOR which leads to increased protein synthesis and lipogenesis. In the fasted state ULK1 starts autophagosome maturation and TFEB/TFE3 increases lysosomal biogenesis and autophagy. Ras-related GTPases (Rags) actually tether mTORC1 to the lysosomal surface and that connection is controlled through amino acid sensing of the vacuolar H+-adenosine triphosphatase ATPase (v-ATPase) as well as the proton-assisted amino acid transporter 1 (PAT1) (Figure 3). SIRT1 is also activated in the fasted state, and by CR mimetics, which increases SOD, p53, and activates FOXO leading to increases in cellular autophagy and mitochondrial biogenesis (Figure 2).
\nmTOR pathway activation, inhibitors, and downstream effects. The molecular pathways increased by caloric restriction that increase lifespan are also targeted by rapamycin, resveratrol, and metformin. Metformin and resveratrol inhibit mTOR through upstream pathways, inhibiting the mitochondrial complex I activity and increasing AMPK respectively. Rapamycin, and rapalogs, on the other hand inhibit mTOR directly. Beneficial downstream effects of mTOR inhibition include increase mitochondrial function and biogenesis, lysosomal biogenesis, autophagy, and decreased translation. Deleterious effects of an active mTOR pathway include increased lipogenesis and inflammation. Beneficial and deleterious interactions or macromolecules are shown in green and or dashed red respectively.
Therapeutics to help extend human lifespan far past the ~100 year limit will likely need to increase autophagy to avoid dementias, a later life disease state. With various dementias (PD, ALS, HD, and AD) having mitochondrial dysfunction [81, 82, 83, 84], and mTOR activation known to increase oxidative stress, antioxidant therapies are being investigated. It has been found conjugating a cation compound to the antioxidant increases uptake into the mitochondria 80-fold and potency up to 800-fold [85] due to its 165 mV negative potential [86]. Low levels of autophagy also result in necrosis instead of apoptosis, with the resulting ramped up immune system increasing inflammation. Intracellular stress acts through Bcl-2 to open the mitochondrial permeability transition pore (mPTP) leading to caspase dependent intrinsic apoptosis [69, 87, 88]. The mPTP is known to exist in 3 states: closed, transiently open in low conductance, and permanently open in high conductance [89, 90, 91], the latter resulting in mitochondrial depolarization, loss of ATP production, and caspase independent necrosis since the controlled apoptotic pathway requires energy [92]. Multiple types of cancer show increased mTOR pathway signaling which is what the first mTOR inhibitors were FDA approved for: sirolimus, everolimus (Afinitor), temsirolimus (Torisel), and ridaforolimus, with sirolimus and everolimus also finding use as immunosuppressants after organ transplants [93].
\nWhile caloric mimics will the not be the panacea pushing human life past 200 years it should be pointed out the large effect it could have in humans compared to other currently measurable lifestyle interventions. The effect was recently quantified for the top five frequent lifestyle interventions: smoking cessation, physical activity, healthy diet, healthy BMI, and low alcohol consumption (Table 1) [94]. Starting at age 50 women and men were found to be able to add on average 14 and 12 years respectively, if all 5 healthy lifestyles were adopted. Never smoking was the strongest healthy habit of the five, with a close second being engaging in physical activity over 30 min a day (which included brisk walking or anything more strenuous). The healthy diet and BMI (18–25 kg/m2) can both clearly be linked to a CR lifestyle. It will be interesting to compare the magnitude of CR life extension to the years gained by aspects of a “healthy diet” which is usually cataloged by many more variables than just caloric count (e.g. vitamin/antioxidants, omega-3 vs. omega-6 vs. saturated fat content). In summary, CR alone seems likely to have as big, or slightly larger, of an effect than the 5 healthy lifestyles in concert. If rapamycin, resveratrol, metformin, or a combination thereof, prove capable of reproducing even half the years of life extension that CR extension can, it would be a multi-billion dollar market (USD) and could be among the best therapeutics measured on the Quality Adjusted Life Years (QALY) scale.
\nLifestyle | \n♀ | \n♂ | \n
---|---|---|
Physical activity (≥30 min/day) | \n8 | \n7 | \n
Not smoking | \n9 | \n12 | \n
Healthy diet | \n5 | \n4 | \n
Low alcohol (15♀, 30♂ g/d = 2♀, 4♂ drinks/d) | \n3 | \n2 | \n
BMI (18–25 kg/m2) | \n4 | \n5 | \n
Extra years if all 5 | \n14 | \n12 | \n
Five healthy lifestyles that extend lifespan more than 10 years.
Five healthy lifestyles (exercise, healthy diet, ideal BMI, low alcohol, and not smoking) were found to add 12–14 years of life starting at age 50 when compared to people that did not follow any of the five lifestyles. The healthiest and worst habits within each lifestyle had very different life expectancies as well, with nonsmokers and excessive smokers having the largest lifespan gap (9–12 years). The second greatest gain in lifespan (7–8 years) came from getting more than 30 min of exercise a day compared to never exercising. Data from [94].
While there are chemically similar caloric restriction (CR) mimetics such as rapalogs for rapamycin, the main compounds discussed: resveratrol, rapamycin, and metformin are chemically distinct. Both resveratrol and metformin are hydrogen-donor rich, having hydroxyls and amides, respectively. Rapamycin is a much larger macrocycle molecule (MW = 914) with both hydrogen donor and acceptor moieties compared to the smaller resveratrol (MW = 228) and rapamycin (MW = 129) (Figure 4). Future docking, crystallography, and NMR studies would be interesting to determine if other molecules could mimic ATP, directly binding to the ATP pocket on mTOR as it has been suggested resveratrol does [78]. A structural mimic of ATP acting as an antagonist can seem conceptually attractive and likely have broad effects on multiple energy sensing proteins, but would also likely have lower than desired specificity.
\nStructures of metabolism modifiers. The structures of compounds discussed: resveratrol, metformin, rapamycin, and ATP. Some have had suggested competitive binding pockets, such as resveratrol and ATP. However on a small molecule scale metformin, resveratrol, and rapamycin have very different complexity and differ by orders of magnitude in molecular weight. All compounds do have significant number of polar groups for hydrogen binding to protein surfaces and pockets.
All three compounds resveratrol, rapamycin, and metformin have had numerous human clinical trials. Metformin is unique among the three in that it is currently an approved and recommended therapy for a massive population, specifically obese individuals with type II diabetes, and therefore has a much larger dataset of patients to pull safety and efficacy information from. Resveratrol and rapamycin are both natural compounds with a plethora of academic papers in animal models, but rapamycin studies have the added nuance/diversity of involving a host of rapalogs with modified activity. A search of clinical trials including the keywords resveratrol, metformin and rapamycin and grouped by topic is shown inTable 2 (as of April 11th 2018). Resveratrol has the lowest number of ongoing clinical trials (137), metformin has over 2.5 fold as many (359), and rapamycin has almost fivefold ongoing clinical trials (646). Resveratrol and metformin have largely overlapping pathway targets in clinical trials with the most common being endocrine system diseases, diabetes mellitus, obesity, and insulin resistance. The main topics for rapamycin are neoplasms by histological type, vascular disease, and myocardial ischemia. Metformin and rapamycin have some overlap, e.g. metformin has 45 current trials listed under neoplasms by histological type, and rapamycin has 42 trials listed under endocrine system diseases.
\nCompound term search at clinicaltrials.gov\n | \n# CT ongoing | \nInsulin resistance | \nDiabetes mellitus | \nEndocrine system diseases | \nObesity | \nNeoplasms by histologic type | \nVascular diseases | \nMyocardial ischemia | \n
---|---|---|---|---|---|---|---|---|
Resveratrol | \n137 | \n28 | \n24 | \n23 | \n19 | \n5 | \n6 | \n1 | \n
Metformin | \n359 | \n34 | \n178 | \n195 | \n34 | \n45 | \n14 | \n5 | \n
Rapamycin | \n646 | \n1 | \n12 | \n42 | \n2 | \n218 | \n172 | \n143 | \n
Ongoing clinical trials for resveratrol, rapamycin, or metformin (April 11th 2018 search of clinicaltrials.gov).
Clinical trials that are ongoing, as of April 11th 2018, were searched for the keywords resveratrol, metformin, and rapamycin. Resveratrol and metformin had overlapping metabolic clinical targets listed, while rapamycin had more numerous trials, which were focused on vascular diseases and cancer.
The use of therapeutics that mimic caloric restriction (CR) is likely to increase and add incremental quality-adjusted life years (QALYs). Natural CR compounds, and analogs based off of them, are fairly cheap with low side effects. Controlled animal studies will likely continue to be the avenue which exposes the degree to which molecular pathways are responsible for the increased quality and quantity of life. Resveratrol and metformin seem robust at increasing molecular pathways linked to quality of health and are useful to combat obesity and type II diabetes; while their ability to increase maximum lifespan remains in question. Data suggests rapamycin and the follow on rapalogs could add years to a human lifespan, although the magnitude of the effect could be enhanced or completely ablated based on accompanying lifestyle choices (diet, exercise, sleep).
\nResearch shedding light on the optimum dosing of caloric mimics should be interesting to follow. Caloric restriction studies in humans fall into three categories: continual modest decrease in calories consumed (~1500 kcal/day), temporary drastic reduction in energy intake (~500 kcal/day), or intermittent fasting (0 kcal/day) in which only water is consumed for 1–3 days. Intermittent fasting has actually slightly outperformed all other methods of dieting methods (atkins, zone, weight watchers, ornish/vegan) in reducing weight in humans, which is partially due to increased compliance [95, 96]. The degree to which molecular pathway changes from intermittent fasting are responsible for reduced weight, such as increased autophagy, remains to be determined. The number of calories that can be consumed above complete fasting, while still increasing autophagy and decreasing inflammation, needs further investigation [1, 10, 44, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108].
\nIt would be very useful for clinicians and patients to have a curve in which the x-axis showed calories consumed per day and the y-axis showed %change in these important life extension pathways (e.g. autophagy, inflammation, lipogenesis, lysosomal biogenesis, and protein synthesis). These studies/curves would ideally be done separately for various groups (e.g. males, females, diabetics, elderly predementia, and elderly with early dementia). The interaction of therapeutics that mimic CR in combination with a changing intake of calories from fluctuating diet will require significant large studies and clear simplifications for clinicians and patients to utilize that information and make actionable in daily life. The actionable timeline for CR mimics is still being investigated, but if studies from intermittent fasting apply then administration for months could be useful but lifetime use will be needed to maximize benefits.
\n4E-BP1 | eukaryotic translation initiation factor 4E-binding protein 1 |
AD | Alzheimer disease |
ALS | amyotrophic lateral sclerosis |
AKT | AKT Serine/Threonine Kinase 1 |
AMPK | AMP-activated protein kinase |
APC | antigen-presenting cells |
CeACAD10 | C. elegans ortholog of acyl-CoA dehydrogenase family member 10 |
CLS | chronological life span |
CR | caloric restriction |
DEPTOR | DEP domain containing mTOR-interacting protein |
eif-4E | eukaryotic translation initiation factor 4E |
eNHE | Na1/H1 exchangers |
ERCC2 | ERCC Excision Repair 2 (ERCC2) |
FOXO | forkhead transcription factors of the O class |
GHSR | growth hormone secretagogue receptor |
HD | Huntington disease |
IIS | insulin/insulin-like growth factor signaling |
IKK | IκB alpha kinase |
MAPK3 | mitogen-activated protein kinase 3 |
mLST8 | mammalian lethal with sec-13 protein 8 |
mPTP | mitochondrial permeability transition pore |
MRE11A | double strand break repair nuclease MRE11 |
mSIN1 | mammalian stress-activated map kinase-interacting protein 1 |
mTORC1 | mTOR complex 1 |
mTORC2 | mTOR complex 2 |
NIA | National Institute on aging |
NPC | nuclear pore complex |
PAT1 | proton-assisted amino acid transporter 1 |
PD | Parkinson disease |
PGC-1α | proliferators-activated receptor gamma coactivator-1 alpha |
PKC | protein kinase C |
QALY | Quality Adjusted Life Years |
Rags | Ras-related GTPases |
Raptor | regulatory-associated protein of mTOR |
Rictor | rapamycin-insensitive companion of TOR |
RLS | replicative lifespan |
ROS | reactive oxygen species |
SIRT1 | sirtuin-1 |
SOD | superoxide dismutase |
Src | proto-oncogene tyrosine-protein kinase |
STAT3 | signal transducer and activator of transcription 3 |
T2DM | type 2 diabetes mellitus |
telO2 | telomere maintenance 2 |
TFEB/TFE3 | transcription factor EB/E3 |
tti1 | telO2-interacting protein 1 |
TXNRD1 | thioredoxin reductase |
ULK1 | Unc-51 like autophagy activating kinase |
v-ATPase | vacuolar H+-adenosine triphosphatase ATPase |
V-ATPase | vacuolar (H+)-ATPase |
YY1 | Ying-Yang 1 |
Corrosion is an unstoppable phenomenon, in order to avoid or reduce the corrosion of metallic materials; the corrosion inhibitor is one of the most effective and flexible means of corrosion prevention and mitigation [1].
According to ISO 8044, the corrosion inhibitor is a chemical substance added to the corrosion system at a concentration chosen for its effectiveness; this causes a decrease in the corrosion rate of the metal without significantly modifying the concentration of any corrosive agent contained in the aggressive medium [2]. In addition, this role can be assured by other ways such as modification of the pH and incorporation of some metals like zinc in the chemical composition of the materials. In fact, such a definition cannot be perfect; however, it avoids to consider inhibitors as additives.
From this definition, a corrosion inhibitor must therefore verify some fundamental properties:
Decreasing the corrosion rate of the metal while retaining the physicochemical characteristics of the latter
Stable in the presence of other constituents, in particular with respect to certain biocides
Stable in the temperature range used
Effective at low concentrations
Inexpensive compared to the savings it allows to achieve
Compatible with the current standards of nontoxicity and environmental pro-tection
A corrosion inhibitor can be used as method of protection:
As a
As a
As a
Various authors have classified the corrosion inhibitors differently. Some authors prefer to group the inhibitors by their chemical functionality (organic or inorganic), others by their electrochemical reaction. Figure 1 presents the classification of the corrosion inhibitors.
Corrosion inhibitor classification.
The corrosion inhibitors can be classified in the liquid phase as a cathodic, anodic, or mixed.
Effect of addition of the cathodic inhibitor.
Anodic inhibitors can actually cause pitting and accelerate corrosion when concentrations fall below minimum limits. This kind of problem is not encountered in the case of cathodic inhibitors (Figure 3).
Effect of addition of the anodic inhibitor.
Effect of addition of the mixed inhibitor.
Each type of inhibitor is characterized by its action mode: adsorption, barrier, reinforcing of the oxide layer, passivation, and formed insoluble complex.
In the case of the interposition of a barrier between the metal and the corrosive medium, which is essential in acidic backgrounds, the role of adsorption of the compounds on the surface is essential.
The reinforcement of a pre-existing barrier, in general the oxide or hydroxide layer formed naturally in a neutral or alkaline medium, may consist of an extension of the oxide to the surface or of the precipitation of salts with weak places of the oxide, these salts being corrosive agents.
The formation of the barrier by interaction between the inhibitor and one or more species of the corrosive medium is a type of mechanism which is also specific for neutral or alkaline media.
Obviously, taking into these general notions, the mechanism of action of an inhibitor can be considered under two aspects: a mechanistic aspect (intervention in the fundamental corrosion processes) and a morphological aspect (intervention of the inhibitory molecule in the interfacial structure). It is also clear that the mechanism of action will differentiate strongly depending on the pH characteristics of the medium.
Volatile corrosion inhibitor is referred to as gas molecules used as a corrosion inhibitor; they are intended for the temporary protection of metallic materials placed in the atmosphere, essentially in storage or transport condition. Their use is made either in the form of wrapping papers impregnated with product or in the form of powder or by spraying with a solution (volatile solvent) [8] (Figure 5).
Volatile corrosion inhibitor mechanism.
Vapor phase inhibitors (VPI) or volatile corrosion inhibitors (VCI) are low nitrogen base salts (cyclohexylamine, dicyclohexylamine, guanidine), and weak acids (nitrous acid, carbonic acid, benzoic acid). The organic part ensures volatility and a certain protective power, and the inorganic part adjusts the volatility, which must correspond to vapor pressures between 10−4 and 10−2 mmHg at room temperature, and ensures the supply of groups of protectors (Ph-COO▬…).
The inhibitor molecules acts by different ways; they are transported or dissociated on the metal surface to ensure an excellent protection by:
pH effect
Adsorption leading to hydrophobization of the surface
Effect on electrochemical processes, essentially on the anodic process: blocking of sites or passivation
The adsorption is more of a chemical type, and the molecule is difficult to remove afterwards. Despite this, the protective action is only maintained if the source of the inhibitor is itself maintained in the immediate environment of the metal surface.
The molecule inhibitors have three areas of application which are in particular important for the use of these products: the petroleum industry, water treatment, and pickling/cleaning of metals. Other applications exist for inhibitors, which involve then more specific formulations, which will be described in the following.
These are essentially the inhibitors added to the paints.
The incorporation of a pigment having inhibitory properties in the coating primer provides most of the corrosion resistance provided by the coating. There are two types of pigments: the active inhibitor pigment and the inactive inhibitor pigment.
The
At the same time, it helps maintain an optimal ratio between the pigment volume concentration and the critical pigment volume concentration that means the film is not too compact to avoid blistering nor too loose to prevent the penetration of aggressive ions (Cl−).
Main inhibitors used
Zinc-based formulations include:
Zinc powder, which provides cathodic protection of the steel coated, provided that the dry extract is greater than 92% of the mass paint.
Zinc chromate, used because of its solubility in water; very effective in paints on aluminum, as well as strontium chromate.
Lead-based formulations include:
Lead powder, whose mode of action is complex and passing probably by modifying the pH of the aqueous medium on contact paint (alkalization) and metal and reverse polarity between iron and lead, explaining cathodic protection of the ferrous material.
Lead oxide Pb3O4, many mechanisms of action are proposed: formation of mixed protective layers of PbO oxide corrosion products, formation of soaps with constituents of paint, etc.
The
Although their use could theoretically be envisaged in most cases of corrosion (with, as main limitations, too large volume of the corrosive medium or the possible impossibility of incorporating additives therein), inhibitors have several traditional application fields [10]:
Water treatment (sanitary water, industrial process water, boiler water, etc.).
Petroleum industry: drilling, extraction, refining, storage, and transport; at all stages of this industry, the use of corrosion inhibitors is essential for the safeguarding of installations.
Temporary protection of metals, whether during acid pickling and cleaning of installations or storage in the atmosphere (volatile inhibitors, incorporation into oils and greases for temporary protection) or for the treatment of cutting oils.
Paint industry on metals where the inhibitors are additives ensuring the anticorrosion protection of metals.
GCI is the molecule extract from plants; it has a double effect because it has a good ability to protect the metals and no negative effect on the environment at the same time.
In the last few years, the researcher community had oriented to inhibitors extracted from plants such as essential and vegetable oil, flavonoids, coumarins, steroids, terpenoids, and condensed tannins. These substances are excellent inhibitors because they contain heteroatoms such as an N, O, P, and S. The free electrons on the heteroatoms form bonds with the electrons on the metal surface. Some atoms in water ionize to release a proton; thus, the now negatively charged heteroatom helps to free an electron on the heteroatom and forms a stronger bond with the metallic electrons. These properties confer them good inhibition properties.
The following table summarized some green inhibitors used for corrosion inhibition of steels, steel alloys, aluminums, aluminum alloys, and other metals and alloys (Table 1).
Metal | Inhibitor source | Active ingredient | References |
---|---|---|---|
Steel | Tamarind | [11] | |
Steel | Tea leaves | [12] | |
Steel | Eucalyptus oil | Monomtrene 1,8-cineole | [13] |
C-steel, Ni, Zn | Lawsonia extract (henna) | Lawsone (2-hydroxy-1,4-napthoquinone resin and tannin, coumarine, Gallic, acid, and sterols) | [14] |
Mild steel | Gum exudate | Hexuronic acid, neutral sugar residues, volatile monoterpenes, canaric and related triterpene acids, reducing and nonreducing sugars | [15] |
Mild steel | Garcinia kola seed | Primary and secondary aminesUnsaturated fatty acids and biflavnone | [16] |
Steel | Aloe leaves | [17] | |
Steel | Mango/orange peels | [18] | |
Steel | Hibiscus sabdariffa (Calyx extract) in 1 M H2SO4 and 2 M HCl solutions, stock 10–50% | Molecular protonated organic species in the extract. Ascorbic acid, amino acids, flavonoids, Pigments and carotene | [19] |
Al-Mg alloy | Aqueous extract of | Catechin | [20] |
Al | Opuntia (modified stems cladodes) | Polysaccharide (mucilage and pectin) | [21] |
Zn | Metal chelates of citric acid | [22] | |
Zn | Onion juice | S-containing acids (glutamyl peptides) S-(1-propenyl) L-cysteine sulfoxide, and S-2-carboxypropyl glutathione | [23] |
Sn | Natural honey (acacia chestnut) | [24] | |
Sn | Black radish | [25] |
Green inhibitors used for corrosion inhibition of steel, steel alloys, aluminum, aluminum alloys, and other metals and alloys.
In this part, we will present a study of a green corrosion inhibitor using a formulation prepared based on the
The inhibition effect was evaluated using the electrochemical measurement such as polarization curves and spectroscopy impedance. The electrode surface was characterized by SEM/EDS.
The results of the open circuit potential (OCP) variation of the iron substrate in acidic solution in the presence and in the absence of FCSL are reported in Figure 6.
Variation of the open circuit potential (OCP) of the iron substrate in acidic solution with and without the FCSL formulation.
The results show that in the absence of FCSL, the potential tends to stabilize at −0.51 V, after 20 min.
The addition of the FCSL formulation leads to a shift in the corrosion potential to a positive direction. This important shift of corrosion potential may indicate an important anodic inhibiting effect of FCSL.
The polarization studies of iron were carried out in acid rain solution both in the absence and in the presence of the FCSL formulation.
All of these curves were obtained after 30 min of immersion time of the electrode in electrolytic solution after performing the automatic ohmic drop compensation (ZIR).
The cathodic and anodic polarization curves of iron in simulated acid rain solution with and without various inhibition concentrations are reported in Figure 7.
Potentiodynamic polarization curves of the iron in acid rain solution with and without various inhibition concentrations in the cathodic domain (a) and in the anodic domain (b).
In absence of the inhibitor (Figure 7a), the corrosion current increases rapidly with the cathodic overvoltage until the potential value of −0.8 V/SCE; for more negative potential values, a pseudo-plateau appears in 0.4 mA/cm2, which can be attributed to the oxygen diffusion process, so the cathodic reaction can be expressed in the following equation:
In the cathodic process, the important factor that must be considered is the mass transport [24].
The adding of the formulation to the corrosive solution is accompanied by both a shift of corrosion potential Ecorr toward a more positive potential and a decrease of the current density Icorr, with the disappearance of the diffusion plateau, obtained in the case of the blank solution, in the presence of the FCSL formulation. We observe the formation of the film on the area, which hinders the diffusion of dissolved oxygen toward the electrode surface.
This behavior is associated with the presence of chloride in solution. The anodic reaction can be expressed by the following equation:
According to Figure 7b in the presence of the FCSL formulation, the current density decreases significantly with the presence of the inhibitor. Furthermore, the corrosion potential displayed more positive values, and also the value of the corrosion current density Icorr reduced from 74.9 mA cm−2 in the absence of the inhibitor to 1.0 mA cm−2 in the presence of the inhibitor. So in less than 75 times, then we observe the appearance of a current plateau in a wide potential range.
The inhibition efficiency (% IE) was calculated using the following relation and its value of 98.6%:
The corresponding current plateau value is in the order of 0.03 mA cm−2 in the case of the FSCL formulation. This may indicate that the iron surface is protected by the inhibitor; this protection may be attributed to a passivity of iron substrate resulting from the formation of inhibitor film on the iron electrode surface. Thus results were observed by other authors [27].
From this result, we can conclude that the FSCL formulation is a mixed-type inhibitor that acts by decreasing the current density in both the cathodic and the anodic domains and making the corrosion potential become more anodic.
This good inhibiting effect of the FSCL formulation may be related to the adsorption on the electrode surface by the establishment of a barrier film.
The impedance diagrams in Nyquist and Bode plots in the absence and in the presence of the FCSL at 293 K are represented in Figure 8.
Nyquist and Bode impedance plots of the iron electrode in acidic solution with and without the FCSL.
In the case of the blank solution, as shown in Figure 8, we noted the two capacity loops in the high frequencies and the inductive loop at low frequencies. This inductive effect may be due to the desorption of the H+ ions and salt ions present in the solution or to the redissolution of the passivity surface [26]. In effect, this inductive loop disappeared with the addition of the inhibitor. The same behavior has been observed by other authors [27].
As shown in Figure 8, in the presence of the FCSL formulation, the size of the loops are bigger than in the case of the blank. Indeed, the polarization resistances pass from 380 Ω cm2 in the case of blank to 14,080 Ω cm2 in the presence of inhibitor.
The inhibition efficiency (% IE) was calculated using the following relation and its value of 97.3%:
We noted also a decrease in the electrolyte resistance which may be explicated by the presence of the ionized substances in the formulation.
We can be ascribed to the following contributions. The high-frequency contribution (Cf, Rf) can be attributed to the dielectric character due to the formation of the film on the iron surface in presence of the inhibitor. The low-frequency contribution can be attributed to the double-layer capacitance (Cdl) at the electrolyte/iron interface at the bottom of the pores coupled with the charge transfer resistance (Rt) [10].
The aim of the surface analysis by SEM coupled with the EDX used in this study is firstly to check the hypothesis of the formation of the inhibitor on the electrode surface and secondly to verify its protective qualities against iron corrosion.
Figures 9 and 10 show the area of the substrate of iron with and without the FCSL formulation after 24 h of immersion time in the acidic solution.
SEM micrograph and EDS spectrum of the iron substrate in corrosive solution after 24 h of immersion time in the absence of the FCSL formulation.
SEM micrograph and EDX spectrum of the iron substrate in acidic solution after 24 h of immersion time in the presence of the FCSL formulation.
In the absence of the FSCL formulation (Figure 9), the SEM examination provides that the metallic surface be heavily attacked by the corrosive ions. The EDX spectrum reported in Figure 9 showed the characteristic peaks of the specimen and marked the presence of oxygen atoms.
Also in the case of the presence the FSCL formulation (Figure 10), in the addition of the optimal concentration of the FSCL formulation into the corrosion solution, a smooth surface noted could explain the good protection effect of the inhibitor by a formation of the film. As confirmed by the EDX spectrum, a very low content of oxygen species is revealed.
Corrosion is one of the most destructive phenomena that can affect metallic pieces. Through this work, we present one of the most used method to protect the metals: the corrosion inhibitor. In addition, we present a case study using a green corrosion inhibitor prepared from the oil of
The authors have declared that no conflict of interest exists.
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This chapter explores the scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis: linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition.",book:{id:"7040",slug:"recent-advances-in-cannabinoid-research",title:"Recent Advances in Cannabinoid Research",fullTitle:"Recent Advances in Cannabinoid Research"},signatures:"Katrina Weston-Green",authors:null},{id:"64031",doi:"10.5772/intechopen.81224",title:"Trends of Protein Aggregation in Neurodegenerative Diseases",slug:"trends-of-protein-aggregation-in-neurodegenerative-diseases",totalDownloads:1622,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Protein aggregation trends in neurodegenerative diseases are largely unmapped due to the complex nature of protein-protein interactions and their regulatory machineries such as protein proteolytic systems. Since the protein aggregation process in humans is a slow process, early determination of the patients that will develop neurodegenerative diseases later in life is critical in terms of starting effective treatment, which will reduce the expensive health care. In this chapter, I will discuss the nature of protein aggregation of signature proteins and the status of protein proteolytic systems such as proteasome and autophagosome in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, Huntington’s disease, and prion disease under the light of recent studies including our new findings.",book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Abdulbaki Agbas",authors:[{id:"250609",title:"Prof.",name:"Abdulbaki",middleName:null,surname:"Agbas",slug:"abdulbaki-agbas",fullName:"Abdulbaki Agbas"}]}],mostDownloadedChaptersLast30Days:[{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3560,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"58817",title:"Clinical Application of MR Spectroscopy in Identifying Biochemical Composition of the Intracranial Pathologies",slug:"clinical-application-of-mr-spectroscopy-in-identifying-biochemical-composition-of-the-intracranial-p",totalDownloads:2092,totalCrossrefCites:0,totalDimensionsCites:5,abstract:"Magnetic resonance spectroscopy (MRS) provides useful information regarding metabolic composition in the tissues, and advanced spectroscopic methods are used to quantify markers of tumor membrane turnover and proliferation (e.g., choline (Cho)), energy homoeostasis (e.g., creatine (Cr)), intact glioneuronal structures (e.g., N-acetylaspartate (NAA)), and necrosis (e.g., lactate (Lac) or lipids). Results are usually expressed as metabolite ratios rather than absolute metabolite concentrations. Because glial tumors have some specific metabolic characteristics that differ according to the grade of tumor, there is a potential for MR spectroscopy to increase the sensitivity of routinely used diagnostic imaging. MRS also has many diagnostic applications in neurosciences to support the diagnosis in conditions like demyelination, infections, and dementia and in postradiotherapy cases. Biochemical changes in the metabolism of tumor cells related to malignant transformation are reflected in changes of particular metabolite concentration in the tumor tissue. Our prospective study aimed to analyze the usefulness of proton MR spectroscopy in grading of glioma and to correlate various metabolite ratios like choline/creatine, choline/N-acetylaspartate, N-acetylaspartate/creatine, and lactate/creatine with the histopathological grades of glioma.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"B C Hamsini, Bhavana Nagabhushana Reddy, Sankar Neelakantan\nand Sunitha Palasamudram Kumaran",authors:[{id:"211054",title:"Dr.",name:"Sunitha",middleName:null,surname:"P Kumaran",slug:"sunitha-p-kumaran",fullName:"Sunitha P Kumaran"},{id:"221485",title:"Dr.",name:"Sankar",middleName:null,surname:"Neelakantan",slug:"sankar-neelakantan",fullName:"Sankar Neelakantan"},{id:"398223",title:"Dr.",name:"B C",middleName:null,surname:"Hamsini",slug:"b-c-hamsini",fullName:"B C Hamsini"},{id:"398224",title:"Dr.",name:"Bhavana",middleName:null,surname:"Nagabhushana Reddy",slug:"bhavana-nagabhushana-reddy",fullName:"Bhavana Nagabhushana Reddy"}]},{id:"62431",title:"The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition",slug:"the-united-chemicals-of-cannabis-beneficial-effects-of-cannabis-phytochemicals-on-the-brain-and-cogn",totalDownloads:1834,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"‘Medicinal cannabis’ can be defined as pharmaceutical grade cannabis-based products used for the treatment of illness. Beneficial treatment effects of cannabidiol (CBD), a major non-intoxicating compound isolated from the cannabis plant, have been shown in multiple states of cognitive impairment, including neurodegenerative (Alzheimer’s, Huntington’s and Parkinson’s disease), neuroinflammatory (sepsis-induced encephalopathy) and neurological disorders (ischemic brain injury). CBD can also treat some of the symptoms of schizophrenia, including cognitive deficits (impairments in learning and memory), which is a major symptom domain of the illness that is largely resistant to existing antipsychotic medications. However, empirical evidence suggests the presence of an ‘entourage effect’ in cannabis; that is, observations that medicinal cannabis seems to work better in some instances when administered as a whole-plant extract. While scientific evidence highlights isolated CBD as a strong candidate for treating cognitive impairment, the entourage effect suggests that the co-operation of other plant molecules could provide further benefits. This chapter explores the scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis: linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition.",book:{id:"7040",slug:"recent-advances-in-cannabinoid-research",title:"Recent Advances in Cannabinoid Research",fullTitle:"Recent Advances in Cannabinoid Research"},signatures:"Katrina Weston-Green",authors:null},{id:"68776",title:"Introductory Chapter: The Chemical Basis of Neural Function and Dysfunction",slug:"introductory-chapter-the-chemical-basis-of-neural-function-and-dysfunction",totalDownloads:1125,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Thomas Heinbockel and Antonei B. Csoka",authors:[{id:"70569",title:"Dr.",name:"Thomas",middleName:null,surname:"Heinbockel",slug:"thomas-heinbockel",fullName:"Thomas Heinbockel"},{id:"245650",title:"Dr.",name:"Antonei B.",middleName:null,surname:"Csoka",slug:"antonei-b.-csoka",fullName:"Antonei B. Csoka"}]},{id:"68712",title:"Synaptic Transmission and Amino Acid Neurotransmitters",slug:"synaptic-transmission-and-amino-acid-neurotransmitters",totalDownloads:1377,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"Amino acids are the most abundant neurotransmitters in the brain. Neurotransmitters are synthesized and stored in presynaptic terminals, released from terminals upon stimulation with specific receptors on the postsynaptic cells. Chemical and electrical synapses are specialized biological structures found in the nervous system; they connect neurons together and transmit signals across the neurons. The process of synaptic transmission generates or inhibits electrical impulses in a network of neurons for the processing of information. Glutamate is the primary excitatory neurotransmitter in the brain, while GABA is the principal inhibitory neurotransmitter. The balance of glutamatergic and GABAergic tone is crucial to normal neurologic function. Through synaptic transmission, this information is communicated from the presynaptic cell to the postsynaptic cell. Amino acid neurotransmitters primarily glutamic acid, GABA, aspartic acid, and glycine are single amino acid residues released from presynaptic nerve terminals in response to an action potential and cross the synaptic cleft to bind with specific receptor on the postsynaptic membrane. The integral role of amino acid neurotransmitters is important on the normal functioning of the brain. The presynaptic and postsynaptic events in chemical synapses are subject to use dependent and highly regulated as per the changes in synaptic neurotransmitter release and function.",book:{id:"7480",slug:"neurochemical-basis-of-brain-function-and-dysfunction",title:"Neurochemical Basis of Brain Function and Dysfunction",fullTitle:"Neurochemical Basis of Brain Function and Dysfunction"},signatures:"Manorama Patri",authors:[{id:"196763",title:"Dr.",name:"Manorama",middleName:null,surname:"Patri",slug:"manorama-patri",fullName:"Manorama Patri"}]}],onlineFirstChaptersFilter:{topicId:"212",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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