Grinding conditions.
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
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There are many challenges in health communication, such as the shortage of evaluations on social marketing interventions, the need for a framework to easily apply social marketing practices to campaigns, and the difficulty of applying theory to improve communication. To address these challenges, the four chapters, including an introductory chapter, introduce several health communication topics, including social marketing, the application of theory, and message design to promote social communication. Readers can expect concise topic overviews with clear steps and examples of how to apply the methods discussed in each chapter.",isbn:"978-1-78923-790-0",printIsbn:"978-1-78923-789-4",pdfIsbn:"978-1-83881-686-5",doi:"10.5772/intechopen.72462",price:100,priceEur:109,priceUsd:129,slug:"selected-issues-in-global-health-communications",numberOfPages:90,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"cd4e1fe9cc4490881657a3ac8c80591e",bookSignature:"Muhiuddin Haider and Heather Nicole Platter",publishedDate:"September 26th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6750.jpg",numberOfDownloads:7152,numberOfWosCitations:6,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:13,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:25,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 20th 2017",dateEndSecondStepPublish:"December 11th 2017",dateEndThirdStepPublish:"February 9th 2018",dateEndFourthStepPublish:"April 30th 2018",dateEndFifthStepPublish:"June 29th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"38977",title:"Prof.",name:"Muhiuddin",middleName:null,surname:"Haider",slug:"muhiuddin-haider",fullName:"Muhiuddin Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/38977/images/6387_n.jpg",biography:"Muhiuddin Haider, Ph.D., is a Clinical Professor in Global Health in the University of Maryland School of Public Health’s Institute for Applied Environmental Health. Since 2009, he has been teaching undergraduate courses under the Public Health Science and Global Health Scholars Programs, while also teaching graduate level courses in the Global Health Certificate Program offered through the University of Maryland School of Public Health. In addition to teaching, Dr. Haider is currently a co-investigator in Project HEAL: Health through Early Awareness and Learning, an intervention to increase cancer screening in African American faith-based communities in Prince Georges County, Maryland. He is also the Principal Investigator on a study to assess the US Public Health Service Commissioned Corps Officers’ value to public health.\r\n\r\nDr. Haider is a highly skilled public health professional who has managed and led diverse public health projects and research studies in more than a dozen countries worldwide over the past thirty years, on behalf of several international agencies and universities. He has assisted multi-sector initiatives to advance the delivery of quality health care services in the areas of Avian Influenza, HIV/AIDS, TB, RH/FP, Malaria, and has developed expertise in the areas of health communication, health promotion, health education, and social marketing. His research into strategies of behavior change, application of social marketing tools and communications capacity building has led to several acclaimed publications.\r\n\r\nHe has led major public health projects in several countries in Africa and Asia, for which he utilized technical skills to stimulate innovative and culturally sensitive approaches grounded in organizational and technical soundness. His recent research and programmatic work has focused on avian and pandemic influenza, for which he has contributed to creating and adapting IEC, BCC, and IPC training materials to establish and implement best practices within public health care systems and promote public-private partnerships. \r\n\r\nDr. Haider has worked collaboratively on numerous occasions with counterparts in the veterinary and agriculture sectors and has advanced the \\One World, One Health\\ framework through curriculum development, targeted coursework for public health students, and the development of a concept paper endorsed by the DOD Veterinary Service Activity, Princeton University based One Health Initiative Advocacy Group, Agricultural Research Service, DOA, and WHO. Dr. Haider has developed and conducted training sessions for Media/Health Reporting, with special focus on AI through DOS/VOA and IBB. Recently, Dr Haider was awarded a Fulbright Scholar Grant to assist the Ecuadorian Nutritional Program, Universidad De Saint Francisco in Quito.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Maryland, College Park",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"238539",title:"Dr.",name:"Heather",middleName:"Nicole",surname:"Platter",slug:"heather-platter",fullName:"Heather Platter",profilePictureURL:"https://mts.intechopen.com/storage/users/238539/images/7884_n.jpg",biography:"Heather Nicole Platter is a doctoral candidate in Behavioral and Community Health in the School of Public Health at the University of Maryland. She completed her Bachelor and Master of Science from the University of Florida. 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This chapter integrates sensemaking theory and organizational risk management processes. In doing so, information is gleaned about gaps in risk communication messaging and dissemination. This proposed model has the potential to enhance the organizational and communication processes necessary to support the cognitive, motivation, and social coordination components in risk communication messaging that underlie H&S decision making.",signatures:"Emily J. Haas and Patrick L. Yorio",downloadPdfUrl:"/chapter/pdf-download/60101",previewPdfUrl:"/chapter/pdf-preview/60101",authors:[{id:"237078",title:"Dr.",name:"Emily",surname:"Haas",slug:"emily-haas",fullName:"Emily Haas"},{id:"240084",title:"Dr.",name:"Patrick",surname:"Yorio",slug:"patrick-yorio",fullName:"Patrick Yorio"}],corrections:null},{id:"60947",title:"Healthcare Message Design toward Social Communication: Convergence Based on Philosophical and Theoretical Perspectives",doi:"10.5772/intechopen.76254",slug:"healthcare-message-design-toward-social-communication-convergence-based-on-philosophical-and-theoret",totalDownloads:1075,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The importance of communication in healthcare has gained considerable attention especially with the rise of the model of patient-centered care. There are many types of messages between healthcare providers and consumers, which is an intangible form of healthcare message design (HMD) as a medium of communication. In the role, HMD is understood as an expansion of universal communicability and plays an important role in social communication. This chapter introduces the concept of HMD based on philosophical underpinnings and theoretical frameworks and defines the process of HMD. For the work, convergence research (or transdisciplinarity, and interdisciplinarity) was conducted, which entails integrating knowledge, theories, methods, data, and expertise from different disciplines.",signatures:"Ji-Young An and Jinkyung Paik",downloadPdfUrl:"/chapter/pdf-download/60947",previewPdfUrl:"/chapter/pdf-preview/60947",authors:[{id:"239298",title:"Prof.",name:"Jiyoung",surname:"An",slug:"jiyoung-an",fullName:"Jiyoung An"},{id:"239956",title:"Prof.",name:"Jinkyung",surname:"Paik",slug:"jinkyung-paik",fullName:"Jinkyung Paik"}],corrections:null},{id:"61405",title:"Social Marketing for Health: Theoretical and Conceptual Considerations",doi:"10.5772/intechopen.76509",slug:"social-marketing-for-health-theoretical-and-conceptual-considerations",totalDownloads:2938,totalCrossrefCites:5,totalDimensionsCites:9,hasAltmetrics:1,abstract:"Marketing, besides education and enforcement, is a strategy to change behaviors. The most important question for commercial marketers is: “What can we do to persuade people to buy our products?” They try to use commercial marketing principles such as exchange theory, consumer orientation, competition, audience segmentation, and marketing mix, to influence customers and sell their products and services. Health is considered as an important market, and people have to pay tangible and intangible costs to buy health products, services, and behaviors. So, health professionals must know about marketing key concepts and designing programs to promote health products and changing health behavior. “Social marketing” is an approach to persuade people to accept ideas and attitudes, perform healthy behaviors, refer to health facilities, and receive health products. In this chapter, the theoretical considerations and practical steps for planning, implementing, and evaluating the interventions based on the social marketing approach will be discussed. At the end of the chapter, we will study four researches designed and implemented based on the social marketing model.",signatures:"Mohsen Shams",downloadPdfUrl:"/chapter/pdf-download/61405",previewPdfUrl:"/chapter/pdf-preview/61405",authors:[{id:"239499",title:"Dr.",name:"Mohsen",surname:"Shams",slug:"mohsen-shams",fullName:"Mohsen Shams"}],corrections:null},{id:"61793",title:"Social Marketing and Health Communication: A Case Study at the Brazilian Federal Senate",doi:"10.5772/intechopen.78126",slug:"social-marketing-and-health-communication-a-case-study-at-the-brazilian-federal-senate",totalDownloads:1112,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This chapter aims to show how a breast cancer campaign can be successfully planned and how the expected results can be achieved, in accordance with the best practices of health communication under the social marketing paradigm. The case study is the Pink October (month dedicated to women’s health) at the Brazilian Federal Senate, in 2017, result of interdepartmental (Top Management, Health, Human Resources and Social Communication areas) and interinstitutional (Federal Senate, Government of the Federal District and health-related institutions) partnership efforts. Social marketing, internal marketing and endobranding concepts are explored, as well as the breast cancer issue, in order to provide a better understanding among interested readers. While results are positive, some challenges and concerns are brought to light, which point to the need for improvements in the Pink October program for the coming years. The case study involved literature review, analysis of media articles and focused interviews.",signatures:"Paulo Ricardo dos Santos Meira, Ilana Trombka and Daniele\nCarvalho Calvano Mendes",downloadPdfUrl:"/chapter/pdf-download/61793",previewPdfUrl:"/chapter/pdf-preview/61793",authors:[{id:"239468",title:"Dr.",name:"Paulo",surname:"Meira",slug:"paulo-meira",fullName:"Paulo Meira"},{id:"246215",title:"MSc.",name:"Ilana",surname:"Trombka",slug:"ilana-trombka",fullName:"Ilana Trombka"},{id:"246216",title:"Dr.",name:"Daniele",surname:"Mendes",slug:"daniele-mendes",fullName:"Daniele Mendes"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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\r\n\tThe importance of education and care in the early stages of life has long been debated and documented. However, in a world that faces ongoing crises and challenges, early childhood education is in a constant quest for pedagogies that respond to acute problems such as:
\r\n\r\n\ta. Environmental crises which result in food & water shortages
\r\n\tb. The growth of digital environments which can educate and empower as well as exploit and destroy (mobile learning, STEM education, tablets, etc.).
\r\n\tc. Social, racial, class, and gender-based discriminations that restrict the developmental potential and the prosperity perspectives
\r\n\td. Health hazards and illnesses such as the laters COVID-19 pandemic.
\r\n\te. Armed conflicts with casualties and displacements of populations seeking refuge
\r\n\tf. Lack of physical spaces that will support and nourish development and learning, etc.
\r\n\tEducation in the post-modern era strives to address the above issues and develop policies, curricula, methodologies, and strategies to contribute to an environmentally and socially sustainable future. It embraces multiple perspectives and worldviews and seeks to touch on inequalities and discriminations in favor of equity. In this direction, children’s s agency lies at the heart of democratic approaches. Educational processes adopt forms of interactions that actualize learning as “becoming” and place it in a continuum between past, present, and future. This book intends to feature innovative approaches that employ transformative elements (targets, methods, materials, ideas, etc.) and embrace the concept of child development as “becoming” in an ever-changing and challenging world.
\r\n\r\n\tWe invite authors to contribute original research or research review papers that present innovative approaches addressing personal and social transformation. All aspects of early childhood education will be considered, including research methodology for the early years.
",isbn:"978-1-80355-949-0",printIsbn:"978-1-80355-948-3",pdfIsbn:"978-1-80355-950-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"351c41dca5c8c997f15e758f2e035178",bookSignature:"Dr. Maria Ampartzaki and Associate Prof. Michail Kalogiannakis",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11281.jpg",keywords:"Early Childhood Education, Preschool, STEAM, Environmental Sustainability, Social Sciences, Social Sustainability, ICT, Digital Devices, Education for Equity, Gender Issues, Post-modern Epistemology, Social Constructivism",numberOfDownloads:65,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 16th 2021",dateEndSecondStepPublish:"December 14th 2021",dateEndThirdStepPublish:"February 12th 2022",dateEndFourthStepPublish:"May 3rd 2022",dateEndFifthStepPublish:"July 2nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"8 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education.",coeditorOneBiosketch:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool\r\nEducation, University of Crete in Greece. He graduated from the Physics Department\r\nof the University of Crete and continued his post-graduate studies at the University\r\nParis-7 and University Paris-5 and received his Ph.D. degree at the University Paris 5.\r\nHis research interests include science education in early childhood, science teaching\r\nand learning, e-learning, the use of ICT in science education, and games simulations.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}}],coeditorOne:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:[{id:"81575",title:"Caring about Early Childhood Education",slug:"caring-about-early-childhood-education",totalDownloads:15,totalCrossrefCites:0,authors:[null]},{id:"80874",title:"Postmodernist Ideas and Their Translation into a Critical Pedagogy for Young Children",slug:"postmodernist-ideas-and-their-translation-into-a-critical-pedagogy-for-young-children",totalDownloads:38,totalCrossrefCites:0,authors:[{id:"338161",title:"Dr.",name:"John",surname:"Wilkinson",slug:"john-wilkinson",fullName:"John Wilkinson"}]},{id:"82431",title:"Next-Generation Science and Engineering Teaching Practices in a Preschool Classroom",slug:"next-generation-science-and-engineering-teaching-practices-in-a-preschool-classroom",totalDownloads:12,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440212",firstName:"Elena",lastName:"Vracaric",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440212/images/20007_n.jpg",email:"elena@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Therefore, many studies on the relationship between the wear behavior and the self-sharpening of the grain cutting edges have been carried out (Yoshikawa, 1960; Tsuwa, 1961; Ichida et al., 1989, 1995; Malkin, 1989; Show, 1996). However, it is very difficult to evaluate this relation quantitatively because of the complexity in wear mechanism and the irregularity in shape and distribution of the grain cutting edges (Webster & Tricard, 2004). Especially, self-sharpening of the cutting edges in the grinding process with cBN wheels has not yet been clarified sufficiently (Ichida et al. 1997, 2006; Guo etal., 2007). To develop an innovative machining system using cBN grinding wheels, it is essential to clarify the self-sharpening mechanism due to the micro fracturing of the cutting edges that is the most important factor controlling the grinding ability of cBN wheel during the grinding process (Ichida et al. 2006; Kalpakjian, 1995; Comley et al., 2006).
The main purpose of this study is to evaluate quantitatively such a complicated self-sharpening phenomenon of the cutting edges in cBN grinding on the basis of fractal analysis. The changes in three-dimensional surface profile of cBN grain cutting edge in the grinding process are measured using a scanning electron microscope with four electron detectors and evaluated by means of fractal dimension.
There are several methods for calculating fractal dimension (Mandelbrot, 1983; Mandelbrot et al. 1984; Hagiwara et al., 1995; Itoh et al., 1990). In this report, we have used a 3D-fractal analysis that is expanded based on the idea in the fractal analysis using two-dimensional mesh counting method (Sakai et al., 1998). The analysis method is shown as follows. A 3D-profile under test is divided by cube grid with a mesh size of
where
Area of square with mesh size
If the logarithm of both sides is taken, eq. (2) is rewritten as follows;
Fractal dimension
However, actual fractal analysis is conducted according to the following procedures by computer processing in this study. As shown in Fig. 1 (a) , a square grid with mesh size
On the basis of these equations,
Grinding experiments were conducted with surface plunge grinding method on a horizontal spindle surface grinding machine. The schematic illustration of the experimental setup is shown in Fig. 3. A vitrified cBN wheel with a replaceable cBN segment shown in Fig. 3 was used to observe directly the profile of the wheel surface in the grinding process using a three-dimensional (3D) scanning electron microscope with four electron probes (3D-SEM/ EDM3000) (Ichida, 2008). The cBN segment detached for the observation can be precisely returned to former state again. It was confirmed experimentally that the cBN wheel with the replaceable cBN segment has almost the same grinding ability as the usual complete cBN wheel (Fujimoto, 2006).
Method of 3D-fractal analysis (Sample: surface profile of cBN abrasive grain).
Relationship between surface area
Schematic illustration of the experimental setup.
Measurements of grinding characteristic palameters.
The expermental conditions are listed in Table 1. Representative single crystal cBN grain was used for cBN wheel. The dressing of cBN wheel was performed using a rotary diamond dresser (Dressing wheel: SD40Q75M) equipped with an AE sensor under the following dressing conditions: peripheral dressing speed 16.5 m/s, peripheral wheel speed ratio 0.5, dressing lead 0.1 mm/rev, dressing depth of cut 2μm5 times. High speed steel SKH51/JIS (M2/ASTM) is used as the workpiece material.
Grinding method | Surface plunge grinding(Up-cut) |
Grinding wheel | CBN80L100V Dimensions:200 D 10T [mm] |
cBN grain | Single crystal cBN |
Peripheral wheel speed vs | 33 [m/s] |
Work speed vw | 0.1 [m/s] |
Wheel depth of cut a | 10 [μm] |
Grinding fluid | Soluble type (JIS W-2-2) 2% dilution |
Workpiece | High speed steel (JIS/SKH51) Hardness: 65HRC Dimensions:100l×5t×30h [mm] |
Grinding conditions.
This 4-channel secondary electron (SE) detection system enables quantitative surface roughness measurements and enhances the topography by displaying the differential signal calculated from the 4 signals. The intensities of these detected signals are determined by the tilt angle of the specimen surface in relation to the geometric positioning of the detectors. The quantitative angular information can be obtained by the subtraction between the signal intensities of the detectors. By calculating 4 tilting angles (two in X-direction and two in Y-direction) on many spots in the X-Y matrix taken on the specimen, the surface topography of the specimen can be accurately re-constructed by integrating these angles over the matrix.
In this system, no eucentric tiling for stereo pairs is required, thereby simplifying operation and allowing much better precision and resolution than conventional SEMs using stereo photogrammetry. The vertical resolution in measuring a 3D profile using this 3D-SEM is 1 nm.
Illustration of the 4-channel SE detector layout detailing the measurement principle of 3D-SEM.
Grinding wheel wear is an important consideration because adversely affects the shape and accuracy of ground surface. Grinding wheel wear by three different mechanisms: attritious grain wear, grain fracture and, and bond fracture, as shown in Fig.6. In attritious wear, the cutting edges of a sharp grain dull by attrition, developing a wear flat. Wear is caused by the interaction of the grain with the workpiece material, involving both physical and chemical reactions. These reactions are complex and involve diffusion, chemical degradation or decomposition of the grain, fracture at a microscopic scale, plastic deformation, and melting. If the wear flat caused by attritious wear is excessive, the grain becomes dull and grinding becomes inefficient and produces undesirable high temperatures. Optimally, the grain should fracture or fragment at a moderate rate, so that new sharp cutting edges are produced continuously during grinding. This phenomenon is self-sharpening. However, self-sharpening by a large fracture is not suitable for precision grinding, because it gives large wheel wear and bad surface roughness during grinding. Therefore, self-sharpening due to micro fracture as shown in Fig.6 is suitable for effective precision grinding, because it offers small wheel wear and good surface roughness. We call this phenomenon \'micro self sharpening\'(Ichida, 2008).
Wear mechanisms of abrasive grain during grinding.
Fig. 7 shows the change in radial wheel wear
Change of radial wheel wear with increasing stock removal and typical sequential SEM images of wheel working suraface.
There is little research that has quantitatively evaluated self-sharpening phenomenon of grinding wheel. We have tried to grasp the actual behavior of self-sharpening and evaluate it by the attritious wear flat area percentage of the grain cutting edge (Ichida, 2008, 2009).
High magnification SEM image and its contour map of grain A in Fig.7 (
Measuring method of attritious wear flat percentage.
Figure 9 shows the measuring method of the attritious wear flat percentage. Attritious wear flat area
Grain cutting edges on the wheel surface change their shapes in various forms with the progress of wheel wear when the accumulated stock removal
The surface with a micro unevenness formed by the diamond dresser is observed on the tip of the grain cutting edge after dressing, as shown in Fig. 10 (a). And after grinding the stock removal
In addition, between the stock removals from 10000 to 12000 mm3/mm, a small fracture takes place at the right side part of cutting edge and some new sharp edges are formed, and at the same time the wear flat is formed slightly in the center part on the cutting edge surface, as indicated in the comparison between Figs. 10 (f) and (g). Afterward, between the stock removals from 12000 to 14000 mm3/mm, some new sharp edges due to the micro fracture are observed in the middle part on the cutting edge top surface, while the new attritious wear flat is formed again at the upper part of the cutting edge, as indicated in the comparison between Figs. 10 (g) and (h).
Thus, although the grain cutting edges become dull due to the ductile attritious wear, they can reproduce and maintain their sharpness due to the micro fractures occurred repeatedly on their top surfaces. Namely, an actual behavior of the self-sharpening phenomenon due to the micro fracture may be grasped on the basis on the sequential SEM observation method used in this study.
As mentioned above, the shape of the cutting edges on the wheel working surface is variously changed due to the fracture wear or the attritious wear when the accumulated stock removal increases. Such a complicated wear process is evaluated using 3D-fractal dimension. Fractal dimension is calculated in an area of 27.4 × 20.6 μm2 enclosed with white frame in Fig. 10. The center of these areas is almost located in the top part of the cutting edge that acts as an effective edge. The range of mesh size
Change in shape of grain cutting edge with accumulated stock removal (Area X on grain A in
Figure 11 shows the 3D-profiles of the typical eight areas a, b, ----, h on the cutting edge used for fractal analysis (areas enclosed with white frame in Fig. 10). The relationships between mesh size
Sequential 3D-profiles of typical area on grain cutting edge used for fractal analysis (DA: ductile attritious wear, MF: micro fracture).
Relationship between surface area
Change in fractal dimension on top surface profile of grain cutting edge with accumulated stock removal.
To consider the reason for such complicated change of fractal dimension, the attritious wear flat area percentage of the cutting edge was measured. In this study, a percentage of ductile attritious wear area in same area of 27.4 × 20.6 μm2 used for fractal analysis is measured and defined as attritious wear flat area percentage
Change in attritious wear flat percentage on top surface of grain cutting edge with accumulated stock removal.
Relationship between fractal dimension
As shown in Figs. 13 and 14, the cutting edge after dressing comparatively takes a high fractal dimension (
As mentioned above, self-sharpening of the grain cutting edge can be characterized using fractal dimension. Especially, these results show that there is a close relationship between fractal dimension
Fig.16 and 17 show the changes of grinding forces and ground surface roughness with increasing accumulated stock removal, respectively. Under this grinding condition, grinding forces maintains a stable level in the steady-state wear region. Especially, tangential grinding force keeps a small variation between 4 and 6 N/mm in this wear region. On the other hand, although surface roughness increases with increasing stock removal, its increasing rate maintains comparatively low level. Thus, high grinding ability of cBN wheel is brought from such self-sharpening due to micro fracture of grain cutting edges, that is, micro self-sharpening phenomenon.
Changes in grinding forces with increasing accumulated stock removal.
Change of ground surface roughness with increasing accumulated stock removal.
The changes in three-dimensional surface profile of grain cutting edge in the grinding process with cBN wheels have been measured using a 3D-SEM and evaluated by means of fractal dimension. The main results obtained in this study are summarized as follows;
Actual behavior of self-sharpening phenomenon due to the micro fracture in the grinding process can be grasped using sequential observation method with 3D-SEM.
The fractal dimension for surface profile of the cutting edge formed by the micro fracture is higher than that of the cutting edge formed due to ductile attitious wear. An increase in ductile attritous wear flat area on the grain cutting edge results in a decrease in fractal dimension for its surface profile.
The complicated changes in shape of the cutting edge due to self-sharpening can be evaluated quantitatively using fractal dimension.
This research was supported in part by Grants-in-Aid for General Science Research (C) (No.19560106) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Visual information from the eyes generates vast amounts of data for the human brain to process, and provides us with unparalleled clarity and insight into the world we live in. Imaging with terahertz (THz) radiation is a research field that has gained a lot of interest and is in the process of moving from research laboratories to commercial applications [1, 2, 3, 4]. As such, the THz research field has grown so much that it has become impossible for a single human to be able to keep track of all developments [4]. Nevertheless, it is possible to outline why there is great interest and potential in THz imaging technology. Most non-conductive materials and non-polar liquids are THz transparent, useful for non-invasive inspection of many multi-component or buried systems, such as paintings [5], electronic circuits [6], space shuttle panels [7] and carbon-fiber composites [8]. Other possibilities are the measurement of picosecond processes in semiconductors [9], quality control of pharmaceutical tablets [10] and non-invasive detection of explosive substances [11]. A plethora of fundamental material resonances, such as phonons, rotations of molecules and precessions of spins, are observable and controllable by THz radiation [12]. Bio-medical applications are highly alluring most notably because the THz photon energies are non-ionizing and high-water sensitivity gives rise to label-free diagnosis of diseases that alter water content, such as cancer [13] and diabetic foot syndrome [14]. There is also the possibility of damaging or repairing DNA with intense THz radiation [15].
With so many possible applications, the reason why THz radiation is barely used outside of laboratories is due to costs of current THz technology. In particular to imaging, the technology is either too expensive, too slow or sacrifices some detection capability (such as picosecond temporal resolution). This is because materials which are suitable for efficient THz detection simply do not exist. This has resulted in THz detector arrays normally working in either narrowbands [16] or needing cryogenic temperatures for sensitive detection [17]. However, microbolometer arrays have very large bandwidths at room temperature operation [18] and when combined with digital holography they can measure both the amplitude and phase of THz radiation [19, 20]. Unfortunately bolometers achieve frequency resolution with a frequency selective source and they do not offer picosecond temporal resolution. This is acceptable for some applications such as detecting concealed weapons, however for applications where time gated detection is used, for example in extracting depths of painting coatings in original art works [5], it becomes unfeasible. An another imaging technique is to project a THz image on an electro-optic crystal then use visible light CCD arrays to spatially map-out the THz field incident onto the crystal [21, 22]. This does not sacrifice the temporal resolution offered time-domain THz spectrometers, however this needs a regen-amplified Ti:Sapphire laser which makes the whole system big and expensive and has prevented the widespread adoption of this technology despite its capabilities. These imaging techniques are all far-field, apart from [21], meaning that they fail to see detail below
The aforementioned imaging approaches are the standard imaging techniques, relying on a detector array or raster scanning, however there is another alternative. Namely, using a spatially modulated light beam and a single-pixel detector to obtain an image [30]. Approaches based on this technique are commonly called
Single-pixel imaging theory concerns itself with obtaining an image of a scene using a detector that can only measure the total amplitude emanating from the scene. The simplest idea is to raster scan an aperture across the field-of-view, building the image pixel by pixel. However, as the aperture is made smaller and smaller, the signal reaching our detector is reduced. We could increase the light incident onto our detector and overcome detector-noise by simultaneously scanning more apertures during each measurement, an idea that originates with Yates in 1935 [32]. In Figure 1(a) we show the main principle of this idea; we have a light beam that is spatially modulated which propagates through an object and onto a detector with no spatial resolution. It is of the utmost importance that in each measurement we know which apertures were open and which were closed. Without this information we could never reconstruct an image of the object. Each measurement is the dot product of the spatial encoding mask and the transmission function of the object, which is mathematically expressed as
(a) Imaging with a single-element detector. An encoding mask spatially encodes a beam of radiation, then the beam passes through an object and onto the single-element detector. (b) Spatial encoding masks, where the first, second, third and fourth coloumns were constructed from Sylvester Hadamard, cyclic Hadamard, random and Fourier matrices respectively. The green triangle in the cyclic mask is there as a visual guide. (c) 2D image transform examples. Figure (a) was extracted from reference [
where
where the rows of matrix
The Sylvester-Hadamard matrices are binary, meaning that they are easily implemented, specifically with digital micromirror devices which are relatively cheap and have switch rates upto 20 kHz. The reconstruction technique can also be efficiently calculated by just doing the Fast Hadamard-Walsh transform, meaning one does not need to store
The Cyclic-Hadamard matrices, also known as Paley Type I and type II Hadamard matrices as they were first discovered by Paley in 1933 [36], are orthogonal and circulant matrices made of 1 s and -1 s. This means they have large noise robustness, easy binary implementation and they are constructed by having one vector,
Random masks constructed from Bernoulli matrices, or Gaussian random matrices, can also be made from 1 s and -1 s making for easy implementation using binary spatial light modulators. However, these matrices are not directly invertible and using a pseudo-inverse can create stability problems. Therefore convex minimization algorithms are usually used for image reconstruction [30, 31]. The main benefit of this masking approach is that is can be used for undersampling which can greatly reduce the total measurement time at the expense of complicated calculations. References [37, 38] were the first theoretical investigation and one can obtain their reconstruction scripts from reference [39], although reference [40] also freely provides their MATLAB scripts for another minimization algorithm called TVAL3 [41]. These algorithms can be slow, hence a mention needs to be given to reference [42] where Kowarlz et al. creates a pseudo-inverse matrix via Fourier-domain regularization that is able to recover images of quality similar to the slow minimazation algorithms, however with faster calculations based on matrix multiplication methods. Note, they also provide their MATLAB and Python scripts freely on github [43].
Fourier masks are those derived from the Fourier matrix. However, as this is just linear algebra representation of the Fourier transform and we are measuring real images (without imaginary numbers), then we do not need to measure the negative Fourier frequencies as they are just the complex conjugate of their positive frequency counterpart. The Fourier matrix is also orthogonal meaning it has noise robustness equal to the Hadamard matrices as well efficient image reconstruction algorithms, simply the Fast Fourier Transform. These masks, however, are not binary but require grayscale values which limits their deployability. Binary spatial modulators can accomplish this either by temporal dithering, at the expense of slower switch-rates, or by spatial dithering, which creates some quantization errors [34]. Nevertheless, these masks benefit from extensive literature based on the Fourier Transform and various image compression algorithms that can be reversed for image-undersampling procedures.
In this single-pixel imaging modality, the most crucial part is to create a spatially modulated beam. In this respect for the THz regime there are four main methods that can be employed; by creating a physical mechanical mask, by changing the electrical conductivity of a material via the injection/depletion of charge carriers, by controlling the refractive index of liquid crystal cells and by creating a spatially varied beam directly at the THz generation stage.
Creating a physical mask to modulate THz radiation has the great advantage that this is the easiest in terms of manufacturing with great modulation depth,
There is another modulation technique that falls in this mechanical category. Namely, mirror arrays where each mirror can be individually addressed. Such arrays already exist for the visible light regime in the form of digital micromirror arrays (DMD). However, DMD mirrors are with dimensions around 10
Schematic of a single pixel of the THz-SLM for normally incident terahertz waves. The pixel is composed of mirrors that are arranged in 4 rows and 8 columns. (a) OFF-state for a bias voltage of 0 V. all mirrors are inclined and incident terahertz radiation (red) is diffracted away (blue) from the transceiver. (b) ON-state for a bias voltage of 37 V. all mirrors are pulled down to the substrate and incident terahertz radiation (red) is reflected (blue) into the transceiver. (c) Schematic cross-sectional view of an unreleased mirror. The base of the mirror adheres to the parylene C, while the part to be released sits on the poly-Si. (d) Schematic cross-sectional view of a released mirror. The base of the mirror adheres to the parylene C, while the released part is inclined due to residual stress in the Cr-Cu-Cr mirror material. (e) Modulation contrast of the THz-SLM. The contrast exceeds a value of 0.5 for a working range from 0.97 THz to 2.28 THz with a maximum contrast of 0.87 at 1.38 THz. (f) Linear dependence of the detected modulated electric field on the number of switched-ON rows in the THz-SLM. (g) Linear dependence of the detected modulated electric field on the number of switched-ON columns in the THz-SLM. Figure reprinted from reference [
The main principle with this THz modulation technique is based upon the Drude model dielectric function [48, 49].
where
Optical based spatial THz-light modulators are currently the best in terms of achieved switch-rate, operational frequency and ease of implementation. Their switch-rate and operational frequencies are both similar to the electrical modulators in that they also rely on modifying the charge carrier density in some material. However, as they use optical light to achieve this, their experimental implementation is very different and due to the current state of visible-light SLMs they are much easier to be implemented. One starts by patterning a visible light beam and then projecting this spatial pattern onto a semiconductor, thereby creating areas that experience large optical excitation and other areas which are left in their ground state. This in turn creates a spatially varying conductivity/absorption profile on the surface of the semiconductor, and thus if a THz beam passes through this surface then the inverse spatial pattern from the visible-light beam is imparted onto the THz beam. The optical excitation can come in two forms, pulsed and continuous wave. For both cases, the carrier concentration is described by
for carrier generation rate
For continuous wave excitation one needs to consider the photo-carrier generation, recombination and diffusion dynamics within the semiconductor. The steady-state equilibrium carrier concentration within the semiconductor is given by [48].
where
(a) Carrier density (in arbitrary units) for different carrier lifetimes, shown by the colored numbers in ms, as we switch a continuous wave source on and off. (b) Illustration of imaging setup: Using a digital micromirror device and a lens, a pump pulse is spatially structured and projected onto a silicon wafer. This spatially modulates a coincident THz pulse. This THz pulse then passes through an object and is measured on a single-element THz detector. Inset is an optical image of a resolution test target (cartwheel) manufactured from gold on a 6
For pulsed optical-excitation probed by a synchronous THz pulse, Eq. (5) changes because the THz pulse can travel through the spatially photopumped region a few picoseconds after photoexcitation and for
Electrical based modulators are likely to be the long-term future solution for spatial THz modulators because they have very little fundamental limitations. Namely, the maximum switch-rates are limited by the carrier recombination rates meaning they can potentially achieve megahertz switch rates, provided the RC constants of the devices are taken into account, especially with electrically tunable materials such as graphene [58, 59]. Their size is determined by photolithographic manufacturing technologies, which is already orders of magnitudes smaller than the THz wavelengths meaning that pixel sizes can be highly subwavelength. In fact, sometimes THz modulation structures can be too large for some commercial photolithographic systems. They are fully self-contained and compact, which is their main advantage over the optical based modulators (see
One of the first demonstrations of this modulation technique was by Kleine-Ostmann et al. in 2004 [60] where they electronically depleted carriers from a GaAs/AlGaAs interface, achieving about 3% modulation across a broadband frequency range of 0.1 to 2 THz. Since then there have been numerous attempts at improving the modulation depth, see references [61, 62] for recent reviews. These efforts have included enhancing the interaction between the THz wave and the charge carrier regions by metamaterial structures [63, 64]. Others have recently used graphene as the modulator [65, 66]. Using metamaterials or Fabry-Perot type resonances to enhance the modulation depth has the trade-off of reducing the working frequencies of the modulator. A further note is that subwavelength grating structures can enhance the THz modulation over a broadband range [58] for the correct THz polarization.
In 2014 C. M. Watts et al. created an electrical based THz-SLM in reference [67], and Figure 4(a) shows their experimental schematic and part (b) shows an image of their SLM. They electrically change the THz absorption of a 2
(a) Schematic of the single-pixel imaging process utilizing an SLM. An image is spatially modulated by the metamaterial and the resulting radiation is sent to the single-pixel detector. (b) Photograph of the SLM (courtesy of K. burke, Boston College media technology services); total active area of the SLM is (4.8 mm
Another innovative approach to single-pixel imaging is to create a spatially patterned beam at the generation step, rather than generate a homogeneous beam that is then spatially modulated, which has the benefit of not needing a THz-SLM. For the terahertz regime, this can be accomplished by three possible ways. First, having an array of photoconductive antennas [70, 71, 72], however this approach suffers from antenna cross-talk and inefficiency problems arising from the small working-area of the antennas whilst occupying a large area. Further, such antennas arrays have only been used as detectors. The second method is to use an electro-optic (EO) crystal that converts visible-light to THz frequencies via non-linear polarization effects [73]. The generation of THz radiation is localized to where the visible light is, hence projecting a spatially varying light beam will generate a THz-beam with the same spatial features. This idea was implemented by references [74, 75] where they used a used a SLM to pattern an 800 nm femtosecond pulse and project that onto a ZnTe crystal. The third method is similar to the second one, with the difference being the use of a spintronic THz emitter instead of an electro-optic crystal. Here the inverse spin Hall effect is used to generate an ultrafast current transient that generates the THz radiation [76, 77, 78]. The spatial patterning is again done by a visible-light SLM since the THz generation is again localized to areas where the optical-pump was shined upon. This was demonstrated by Chen et al. in reference [79].
The similarities between the spintronic and electro-optic crystal approaches are that they both require femtosecond pulses with mJ/cm
Figure 5(a) shows the experimental setup of reference [79] which uses the spintronic emitter array approach. Note that the EO crystal approach is identical in that you only have to replace the spintronic emitter with the EO crystal and remove the magnetic field, then place the object as close as possible to the emitter array. One should note that the use of the second DMD in Figure 5(a) is only to correct the phase front induced by first DMD, which can also be achieved by the technique shown in the supplementary information of reference [82]. The spintronic emitter is nanometer thick hence Chen et al. was able to resolve metallic lines 6
(a) Schematic of the GHOSTEAM system. The spintronic THz emitter array (STEA) is excited by two-DMD-encoded fs laser pulses and generates spatially coded THz pulses. An object “CAEP” was placed in the near-field region (
Liquid crystal modulators work by the re-orientating the material molecules under an applied voltage. As the molecules are oblong, this changes the refractive index that an electro-magnetic wave experiences. Therefore these devices are great for phase modulation giving the greatest freedom in the values that the sampling matrix can take. In other words, they can theoretically project a Fourier matrix that has grayscale complex-values. Note that complex valued masks can be used in conjunction with an intensity only detector to obtain an image that has phase and amplitude information [83]. A liquid crystal based SLM for THz was computationally studied [84]. However, the re-orientation of the molecules is a slow process, and in the visible light regime liquid crystal displays are typically limited to below 100 Hz switch rates. Due to the longer THz wavelengths, thicker layers of liquid crystals are needed resulting in even slower switch rates. For this reason, liquid crystal spatial modulators for THz radiation have been limited mostly to applications where slow switching speeds are acceptable such as dynamically controllable lenses [85, 86], absorption [87] or polarization control [88].
The first demonstration of a single-pixel THz camera that uses a multi-pixel modulation approach3 was in 2008 by Chan et al. [89]. Therein the authors showed amplitude and phase imaging was possible. Since Chan showed single-pixel THz imaging with metallic masks [89], most publications up until now have focused on improving the implementation by showing proof-of-concept modulation/generation techniques as opposed to potential applications. Shortly after in 2009 spectroscopic imaging was demonstrated [90]. The next experiment was in 2012 by Shen et al. [46] where they used a spinning disc with random masks, but it should be noted that their experiment used an infrared and a THz source whilst using the same SLM. The first demonstration of an optical based SLM was by Shrekenhamer et al. in 2013 [49]. The same group then published an electrical based SLM for single-pixel THz imaging in 2014 [67]. The next developments showed in 2016 that such imaging systems can detect a sub-wavelength fissure (8
The potential applications and capabilities of single-pixel THz cameras are directly determined by the THz source and detector, rather than the technique used to impart a spatial pattern in a beam of THz radiation. As such, it is unlikely for there to be a single-solution for all practical applications. Therefore, it is valuable to discuss where each of the techniques in
The metallic/physical based masks, employed in
Modifying the Drude plasma frequency of a semiconductor via injection/depletion of charge carriers has great potential for compact integration of the entire imaging system, as long as electrical gating is used as it negates the need for an extra pump-laser. The drawback is that to ensure modulation depth over a large frequency range the Drude plasma frequency has to be sufficiently modified. For example, after photoexcitation of silicon if
Direct generation of a spatially varying THz beam,
Although the first experimental implementations of single-pixel cameras can be traced back to 1976 [97], such imaging approaches were not widely studied or implemented in the commercial world. The reason is that the serial measurement of such ideas can not compete with parallel data acquisition of imaging arrays. Further, compressed sensing techniques began gaining mainstream attention in 2006 after two publications [37, 38]. This coincides with the development of visible light spatial modulators thereby allowing the implementation of the ideas in references [37, 38]. Whilst inherently slower than imaging arrays, these single-pixel cameras are much more robust and easier to implement in areas where imaging array technology is unavailable. In particular, the terahertz frequency regime.
This book chapter began by outlining the current state of THz cameras. Then it discusses the background theory of single-pixel imaging techniques. Most of the chapter was dedicated to discussing the current state of spatial THz-light modulators for use in single-pixel THz imaging in
The most advanced THz-SLM at present are those based on optical excitation of semiconductors,
Ultimately, the development of single-pixel THz cameras is likely to proceed with optical modulators being used in university laboratories to optimize the algorithms and methodologies used in image recovery as well as synchronization of all the equipment. Simultaneously there will be an effort to develop electrical based array modulators that have fast-switch rates and large modulation depth over a broadband frequency range. Then the miniaturization of such modulator arrays will start and it is likely that at this point such commercially available THz-SLMs will become available from new specialized start-up companies. Spatially-generated THz beams will likely remain only in laboratories for fundamental studies of different systems, but are unlikely to be used for industrial and commercial applications mostly due to the requirement of pump powers of
This work was partially supported by the Research Grants Council of Hong Kong (project numbers 14206717 and 14201415), The Hong Kong Innovation and Technology Fund (project number ITS/371/16), The Engineering and Physical Sciences Research Council (grant number EP/S021442/1), and the Royal Society Wolfson Merit Award (EPM).
The authors declare no conflict of interest.
Atomic force microscope
Printed Circuit Board
Field-programmable gate array
Spatial light modulator
Terahertz
Electro-optic
Signa-to-noise ratio
Digital micromirror device
Vanadium Dioxide
Charge Coupled device
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"49246",doi:"10.5772/61300",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4727,totalCrossrefCites:27,totalDimensionsCites:63,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]},{id:"70919",doi:"10.5772/intechopen.90891",title:"Antimicrobial Effect of Titanium Dioxide Nanoparticles",slug:"antimicrobial-effect-of-titanium-dioxide-nanoparticles",totalDownloads:1817,totalCrossrefCites:21,totalDimensionsCites:47,abstract:"The widespread use of antibiotics has led to the emergence of multidrug-resistant bacterial strains, and therefore a current concern for food safety and human health. The interest for new antimicrobial substances has been focused toward metal oxide nanoparticles. Specifically, titanium dioxide (TiO2) has been considered as an attractive antimicrobial compound due to its photocatalytic nature and because it is a chemically stable, non-toxic, inexpensive, and Generally Recognized as Safe (GRAS) substance. Several studies have revealed this metal oxide demonstrates excellent antifungal and antibacterial properties against a broad range of both Gram-positive and Gram-negative bacteria. These properties were significantly improved by titanium dioxide nanoparticles (TiO2 NPs) synthesis. In this chapter, latest developments on routes of synthesis of TiO2 NPs and antimicrobial activity of these nanostructures are presented. Furthermore, TiO2 NPs favor the inactivation of microorganisms due to their strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms, such as Escherichia coli and Staphylococcus aureus. Understanding the main mechanisms of antimicrobial action of these nanoparticles was the second main purpose of this chapter.",book:{id:"9521",slug:"antimicrobial-resistance-a-one-health-perspective",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A One Health Perspective"},signatures:"Carol López de Dicastillo, Matias Guerrero Correa, Fernanda B. Martínez, Camilo Streitt and Maria José Galotto",authors:[{id:"244902",title:"Dr.",name:"Carol",middleName:null,surname:"Lopez De Dicastillo",slug:"carol-lopez-de-dicastillo",fullName:"Carol Lopez De Dicastillo"},{id:"315494",title:"Mr.",name:"Matias",middleName:null,surname:"Guerrero Correa",slug:"matias-guerrero-correa",fullName:"Matias Guerrero Correa"},{id:"315495",title:"Ms.",name:"Fernanda",middleName:null,surname:"B. Martínez",slug:"fernanda-b.-martinez",fullName:"Fernanda B. Martínez"},{id:"315496",title:"Mr.",name:"Camilo",middleName:null,surname:"Zuñiga",slug:"camilo-zuniga",fullName:"Camilo Zuñiga"},{id:"315497",title:"Dr.",name:"Maria José",middleName:null,surname:"Galotto",slug:"maria-jose-galotto",fullName:"Maria José Galotto"}]},{id:"65613",doi:"10.5772/intechopen.84411",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9283,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"63397",doi:"10.5772/intechopen.80624",title:"Antibiotic Resistance in Lactic Acid Bacteria",slug:"antibiotic-resistance-in-lactic-acid-bacteria",totalDownloads:2486,totalCrossrefCites:12,totalDimensionsCites:21,abstract:"Most starter cultures belong to the lactic acid bacteria group (LAB) and recognized as safe by the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, LAB may act as intrinsic or extrinsic reservoirs for antibiotic resistance (AR) genes. This fact may not constitute a safety concern itself, as the resistance gene transfer is vertical. Nevertheless, external genetic elements may induce changes that favor the horizontal transfer transmission of resistance from pathogens as well as from the human intestinal microbiota, which represents a severe safety issue. Some genus of AR LAB includes Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus, and Streptococcus isolated from fermented meat and milk products. Currently, the WHO recommends that LAB used in the food industry should be free of resistance. Therefore, the objective of this chapter is to present an overview of the LAB antibiotic resistance and some methods to determine the same.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Yenizey M. Álvarez-Cisneros and Edith Ponce-Alquicira",authors:[{id:"256345",title:"Dr.",name:"Yenizey Merit",middleName:null,surname:"Alvarez Cisneros",slug:"yenizey-merit-alvarez-cisneros",fullName:"Yenizey Merit Alvarez Cisneros"},{id:"256347",title:"Dr.",name:"Edith",middleName:null,surname:"Ponce-Alquicira",slug:"edith-ponce-alquicira",fullName:"Edith Ponce-Alquicira"}]}],mostDownloadedChaptersLast30Days:[{id:"65613",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9277,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"62553",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7327,totalCrossrefCites:43,totalDimensionsCites:92,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"65914",title:"Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance",slug:"introductory-chapter-the-action-mechanisms-of-antibiotics-and-antibiotic-resistance",totalDownloads:4428,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu, Nesrin Gareayaghi and Bekir S. Kocazeybek",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"},{id:"248288",title:"Prof.",name:"Bekir",middleName:null,surname:"Kocazeybek",slug:"bekir-kocazeybek",fullName:"Bekir Kocazeybek"},{id:"406463",title:"Dr.",name:"Nesrin",middleName:null,surname:"Gareayaghi",slug:"nesrin-gareayaghi",fullName:"Nesrin Gareayaghi"}]},{id:"63397",title:"Antibiotic Resistance in Lactic Acid Bacteria",slug:"antibiotic-resistance-in-lactic-acid-bacteria",totalDownloads:2486,totalCrossrefCites:12,totalDimensionsCites:21,abstract:"Most starter cultures belong to the lactic acid bacteria group (LAB) and recognized as safe by the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, LAB may act as intrinsic or extrinsic reservoirs for antibiotic resistance (AR) genes. This fact may not constitute a safety concern itself, as the resistance gene transfer is vertical. Nevertheless, external genetic elements may induce changes that favor the horizontal transfer transmission of resistance from pathogens as well as from the human intestinal microbiota, which represents a severe safety issue. Some genus of AR LAB includes Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus, and Streptococcus isolated from fermented meat and milk products. Currently, the WHO recommends that LAB used in the food industry should be free of resistance. Therefore, the objective of this chapter is to present an overview of the LAB antibiotic resistance and some methods to determine the same.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Yenizey M. Álvarez-Cisneros and Edith Ponce-Alquicira",authors:[{id:"256345",title:"Dr.",name:"Yenizey Merit",middleName:null,surname:"Alvarez Cisneros",slug:"yenizey-merit-alvarez-cisneros",fullName:"Yenizey Merit Alvarez Cisneros"},{id:"256347",title:"Dr.",name:"Edith",middleName:null,surname:"Ponce-Alquicira",slug:"edith-ponce-alquicira",fullName:"Edith Ponce-Alquicira"}]},{id:"49246",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4726,totalCrossrefCites:27,totalDimensionsCites:63,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]}],onlineFirstChaptersFilter:{topicId:"897",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81704",title:"Quorum Sensing Inhibition Based Drugs to Conquer Antimicrobial Resistance",slug:"quorum-sensing-inhibition-based-drugs-to-conquer-antimicrobial-resistance",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104125",abstract:"Quorum sensing is the cell to cell communication mechanism in microorganism through signalling molecules. Regulation of virulence factor, sporulation, proteolytic enzymes production, biofilm formation, auto-inducers, cell population density are key physiological process mediated through quorum-sensing (QS) signalling. Elevation of innate immune system and antibiotic tolerance of pathogens is highly increased with perspective of quorum-sensing (QS) activity. Development of novel drugs is highly attractive scenario against cell-cell communication of microbes. Design of synthetic drugs and natural compounds against QS signal molecules is vital combat system to attenuate microbial pathogenicity. Quorum sensing inhibitors (QSIs), quorum quenchers (QQs), efflux pump inhibitors (EPIs) act against multi-drug resistance strains (MDR) and other pathogenic microbes through regulation of auto-inducers and signal molecule with perceptive to growth arrest both in-vitro and in-vivo. QQs, QSIs and EPIs compounds has been validated with various animal models for high selection pressure on therapeutics arsenal against microbe’s growth inhibition. Promising QSI are phytochemicals and secondary metabolites includes polyacetylenes, alkaloids, polyphenols, terpenoids, quinones.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Kothandapani Sundar, Ramachandira Prabu and Gopal Jayalakshmi"},{id:"82372",title:"Unlocking the Potential of Ghost Probiotics in Combating Antimicrobial Resistance",slug:"unlocking-the-potential-of-ghost-probiotics-in-combating-antimicrobial-resistance",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104126",abstract:"Antimicrobial resistance is a global concern that requires immediate attention. Major causes of development of antimicrobial resistance in microbial cells are overuse of antimicrobials along the food chain especially in livestock, in preventing infections as well as misuse of antimicrobials by patients. Probiotics could be a viable alternative to antibiotics in the fight against antimicrobial resistance. Probiotic strains can act as a complement to antimicrobial therapy, improving antimicrobial function and enhancing immunity. However, there are safety concerns regarding the extensive use of live microbial cells especially in immunocompromised individuals; these include microbial translocation, inhibition of other beneficial microorganisms and development of antimicrobial resistance, among other concerns. Inevitably, ghost probiotics have become the favored alternative as they eliminate the safety and shelf-life problems associated with use of probiotics. Ghost probiotics are non-viable microbial cells (intact or broken) or metabolic products from microorganisms, which when administered in adequate amounts have biologic activity in the host and confer health benefits. Ghost probiotics exert biological effects similar to probiotics. However, the major drawback of using ghost probiotics is that the mechanism of action of these is currently unknown, hence more research is required and regulatory instruments are needed to assure the safety of consumers.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Abigarl Ndudzo, Sakhile Ndlovu, Nesisa Nyathi and Angela Sibanda Makuvise"},{id:"82178",title:"Managing Antimicrobial Resistance beyond the Hospital Antimicrobial Stewardship: The Role of One Health",slug:"managing-antimicrobial-resistance-beyond-the-hospital-antimicrobial-stewardship-the-role-of-one-heal",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104170",abstract:"Infections caused by micro-organisms affect the health of people and animals, causing morbidity and mortality, with Asia and Africa as the epicenters. Some of the infectious diseases are emerging and re-emerging in nature. Examples include viral hepatitis, Lassa fever, Ebola, yellow fever, tuberculosis, covid-19, measles, and malaria, among others. Antimicrobials have been playing an important role in the treatment of infections by these microbes. However, there has been a development of resistance to these antimicrobials as a result of many drivers. This write-up used secondary data to explore the management of antimicrobial resistance (AMR) beyond the hospital antimicrobial resistance steward using the one health concept. The findings showed AMR to be a transboundary, multifaceted ecosystem problem affecting both the developed and developing countries. It is also one of the top ten global public health threats facing mankind. Globally, AMR will cost over US$100 trillion in output loss by 2050, about 700,000 deaths a year, and 4,150,000 deaths in Africa by 2050. About 2.4 million people could die in high-income countries between 2015 and 2050 without a sustained effort to contain AMR. The drivers of AMR are beyond the hospital and hospital AMR stewardship. Therefore, the need for one health concept to manage it.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Istifanus Anekoson Joshua, Mathew Bobai and Clement Sokfa Woje"},{id:"81918",title:"Machine Learning for Antimicrobial Resistance Research and Drug Development",slug:"machine-learning-for-antimicrobial-resistance-research-and-drug-development",totalDownloads:53,totalDimensionsCites:0,doi:"10.5772/intechopen.104841",abstract:"Machine learning is a subfield of artificial intelligence which combines sophisticated algorithms and data to develop predictive models with minimal human interference. This chapter focuses on research that trains machine learning models to study antimicrobial resistance and to discover antimicrobial drugs. An emphasis is placed on applying machine learning models to detect drug resistance among bacterial and fungal pathogens. The role of machine learning in antibacterial and antifungal drug discovery and design is explored. Finally, the challenges and prospects of applying machine learning to advance basic research on and treatment of antimicrobial resistance are discussed. Overall, machine learning promises to advance antimicrobial resistance research and to facilitate the development of antibacterial and antifungal drugs.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Shamanth A. Shankarnarayan, Joshua D. Guthrie and Daniel A. Charlebois"},{id:"81891",title:"Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination",slug:"alternatives-to-antibiotics-in-semen-extenders-used-in-artificial-insemination",totalDownloads:29,totalDimensionsCites:0,doi:"10.5772/intechopen.104226",abstract:"Antimicrobial resistance is a serious global threat requiring a widespread response. Both veterinarians and medical doctors should restrict antibiotic usage to therapeutic use only, after determining the sensitivity of the causal organism. However, the addition of antibiotics to semen extenders for animal artificial insemination represents a hidden, non-therapeutic use of antimicrobial substances. Artificial insemination for livestock breeding is a huge global enterprise with hundreds of million sperm doses prepared annually. However, reporting of antimicrobial resistance in semen is increasing. This review discusses the consequences of bacteria in semen samples, as well as the effect of antimicrobial substances in semen extenders on bacteria in the environment and even on personnel. Alternatives to antibiotics have been reported in the scientific literature and are reviewed here. The most promising of these, removal of the majority of bacteria by colloid centrifugation, is considered in detail, especially results from an artificial insemination study in pigs. In conclusion, colloid centrifugation is a practical method of physically removing bacteria from semen, which does not induce antibiotic resistance. Sperm quality in stored semen samples may be improved at the same time.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Jane M. Morrell, Pongpreecha Malaluang, Aleksandar Cojkic and Ingrid Hansson"},{id:"81699",title:"Efflux Pumps among Urinary E. coli and K. pneumoniae Local Isolates in Hilla City, Iraq",slug:"efflux-pumps-among-urinary-e-coli-and-k-pneumoniae-local-isolates-in-hilla-city-iraq",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.104408",abstract:"Urinary tract infections (UTI) are the most common bacterial infections affecting humans. Escherichia coli and Klebsiella pneumoniae were common enterobacteria engaged with community-acquired UTIs. Efflux pumps were vital resistance mechanisms for antibiotics, especially among enterobacteria. Overexpression of an efflux system, which results in a decrease in antibiotic accumulation, is an effective mechanism for drug resistance. The ATP-binding cassette (ABC) transporters, small multidrug resistance (SMR), and multidrug and toxic compound extrusion (MATE) families, the major facilitator superfamily (MFS), and the resistance-nodulation- cell division (RND) family are the five superfamilies of efflux systems linked to drug resistance. This chapter highlights the results of studying the prevalence of efflux pump genes among local isolates of E. coli and K. pneumoniae in Hilla City, Iraq. class RND AcrAB-TolC, AcrAD-TolC, and AcrFE-TolC genes detected by conventional PCR of E. coli and K. pneumoniae respectively. The result revealed approximately all studied efflux transporter were found in both E. coli and K. pneumoniae in different percentages. Biofilm formation were observed in 50(100%) of K. pneumoniae and 49(98%) of E. coli isolates were biofilm former and follow: 30(60%), 20(40%) were weak, 12(24%), 22(44%) were moderate and 7(14%) and 8(16%) were Strong biofilm former for E. coli and K. pneumoniae, respectively.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Hussein Al-Dahmoshi, Sahar A. Ali and Noor Al-Khafaji"}],onlineFirstChaptersTotal:13},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:7,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",slug:"abdelhamid-mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",slug:"ali-al-ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",slug:"carmelo-bastos-filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",slug:"efren-gorrostieta-hurtado",fullName:"Efren Gorrostieta 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from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö 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