Antibacterial activity data of Schiff base (2a) and its metal complexes (3a, 4a and 5a) against E. coli, S. aureus and B. cereus with their minimum zone of inhibition and MIC (μg/mL) mm values.
\r\n\t
",isbn:"978-1-83968-460-9",printIsbn:"978-1-83968-459-3",pdfIsbn:"978-1-83969-232-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,hash:"babca2dea1c80719111734cc57a21a4c",bookSignature:"Dr. Amin Talei",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10404.jpg",keywords:"Water Budget, Ground Measurement, Satellite Data, Empirical Models, Physical Models, Data-Driven Models, Artificial Neural Network, Neuro-Fuzzy Systems, Genetic Programming, Irrigation Management, Drought, Aquifer Management",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 29th 2020",dateEndSecondStepPublish:"November 26th 2020",dateEndThirdStepPublish:"January 25th 2021",dateEndFourthStepPublish:"April 15th 2021",dateEndFifthStepPublish:"June 14th 2021",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in developing hydrological models using adaptive neuro-fuzzy systems, a pioneering researcher in tropical biofiltration systems, appointed head of the Civil Engineering Discipline in Monash University Malaysia.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"335732",title:"Dr.",name:"Amin",middleName:null,surname:"Talei",slug:"amin-talei",fullName:"Amin Talei",profilePictureURL:"https://mts.intechopen.com/storage/users/335732/images/system/335732.jpg",biography:"Associate Professor Amin Talei joined Monash University Malaysia in January 2013 and currently is the head of Civil Engineering discipline. His previous appointment was as researcher in School of Civil & Environmental Engineering of Nanyang Technological University of Singapore where he studied for his PhD during 2008-2011. His research is predominantly focused on hydrological modeling and flood forecasting using artificial intelligence techniques. Most recently, he has been also involved in research projects dealing with sustainable urban water management. To date, he has published over 50 articles in reputable journals and international conference proceedings. He has supervised several PhD and Master students and won the Supervisor of the Year Award in Monash University Malaysia in 2017. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4816",title:"Face Recognition",subtitle:null,isOpenForSubmission:!1,hash:"146063b5359146b7718ea86bad47c8eb",slug:"face_recognition",bookSignature:"Kresimir Delac and Mislav Grgic",coverURL:"https://cdn.intechopen.com/books/images_new/4816.jpg",editedByType:"Edited by",editors:[{id:"528",title:"Dr.",name:"Kresimir",surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"62416",title:"The Periodontal-Endodontic Relationship, What Do We Know?",doi:"10.5772/intechopen.78664",slug:"the-periodontal-endodontic-relationship-what-do-we-know-",body:'\nThe close inter-relationship between the periodontium and root canal systems has resulted in concomitant lesions from both entities, leading to periodontal-endodontic (perio-endo) infections that, to date, remain a challenge for the dental professional to both diagnose and manage. An in-depth understanding of the anatomy and disease pathogenesis is of utmost importance in assisting clinicians to establish a prognosis, derive a rational treatment plan and troubleshoot complicated cases grounded on sound biological and clinical bases. In this chapter, evidence-based and contemporary approaches to managing periodontal and/or endodontic lesions will be discussed collectively.
\nPeriodontal disease is an inflammatory disease of the tooth supporting structures initiated by bacteria that form a biofilm on the tooth/root surfaces [1]. Root canal infections (i.e. apical periodontitis) are multi-microbial, biofilm-associated diseases [2, 3]. Apical ramifications, lateral canals, and isthmuses connecting main root canals may harbor biofilm-like microbial structures [2]. The communications between the pulp and the periodontium occur primarily through: exposed dentinal tubules, small portal of exits - e.g. accessory canals and lateral canals - and via the apical foramen [4, 5]. As such, it is unsurprising that pathogens infecting the periodontium and root canal systems are highly similar, indicative of an inseparable relationship between the root canal system and the periodontium [6].
\nIn chronic apical abscesses caused by endodontic infections, a localized collection of pus with a draining sinus may track through the periodontium, forming a deep, narrow and isolated periodontal pocket, adjacent to, or alongside, the gingival sulcus. For molars or multi-rooted teeth, radiographic examination may reveal a radiolucent area at the furcation of an infected tooth, indicating presence of accessory canals which drain into the furcation area [4].
\nJansson et al. [7] reported that teeth in periodontitis-prone patients lost more attachment when a continuous root canal infection was present compared to teeth with no periapical lesions. Such findings were also observed by Ehnevid et al. [8] who concluded that a root-canal infection, if left untreated, may impair periodontal healing following non-surgical periodontal therapy. When the pulp is the source of infection, considerations should be given towards treating the endodontic infections prior to periodontal treatment [5, 9]. Such an approach is aimed at eliminating the source of pulpal infection prior to periodontal therapy, as root instrumentation may remove the protective cementum layer [10] and communicate residual infection through exposed dentinal tubules or accessory canals [11, 12].
\nAn inflamed periodontium resulting from a periodontal infection may affect the vitality of the pulp. Seltzer and Bender [13], reported that periodontal lesions could potentially infect the pulp through numerous lateral and accessory canals in the furcation area. The authors found that 79% of periodontally involved teeth, without caries and restorations, exhibited histological evidence of pulpal pathology. In periodontal disease affected teeth, localized pulpal necrosis adjacent to accessory canals was found [13].
\nLangeland et al. [14] reported that the effect of periodontal disease on the pulp was degenerative in nature, resulting in pulpal inflammation, calcifications and resorption. Such insults from periodontal disease to the pulp were cumulative over time [14]. Similarly, Wan et al. [15] reported that the severity of periodontitis had substantial effect on pulpal health. They speculated that denuded root surfaces could induce more pathological changes within the pulp [15]. Root surfaces may be denuded of the protective cementum layer as a result of periodontal treatment [16], developmental defects [17] or even due to direct bacterial invasion [18]. Denuded surfaces are thought to allow passage of microorganisms between the pulp and periodontal tissues through patent dentinal tubules, lateral or accessory canals [18]. Furthermore, if the microvasculature of the apical foramen remains intact, the pulp may maintain its vitality [14].
\nThe dental pulp and periodontium are closely related both anatomically and functionally, through three different channels of communication – as discussed below.
\nThe root canal system is a complicated system with the apical foramen as the principal route of communication between the pulp and the periodontium. A single apical foramen is the exception rather than the rule. Multiple foramina, fins, deltas, loops, and furcations are usually present at the apical end of the root canal [19]. Bacteria, bacterial toxins, inflammatory by-products and mediators pass readily through the apical foramen into the root canal eliciting inflammation of the pulp and subsequently pulpal necrosis [20].
\nIf periodontal disease reaches the apical foramen, such inflammatory reactions may spread both ways leading to perio-endo pathologies. Similarly, infection from an infected pulp may exit the apical foramen, track through the periodontium, eliciting tissue destruction and formation of what registers clinically as a periodontal pocket.
\nAccessory or lateral canals from the dental pulp may be formed during formation of the root sheath. A break develops in the continuity of the sheath, producing a small gap, which results in a small “accessory” canal between the dental sac and the pulp. Accessory and lateral canals can be seen anywhere along the root, creating a potential perio-endo pathway of communication [21]. Studies have reported that nerve fiber and blood vessels are commonly present in these lateral canals. They are found to traverse the periodontal ligament, course through the portal on cementum wall, root dentin and connect to the main root canal system [22]. Approximately 17% of teeth may present with multiple canal systems in the apical third of the root, about 9% in the middle third and fewer than 2% in the coronal third [23]. It has been reported that debridement at molar furcation areas may increase the risk of bacterial contamination of the pulp by 39% through exposed dentin or furcation canals [24].
\nAs periodontitis gradually destroys the periodontal ligament between the cementum and bone, cementum becomes exposed to the oral environment via periodontal pockets and through gingiva recession. Destruction of Sharpey’s fibers leaves a sieve-like surface on the cementum, full of canals which may be contaminated by bacteria and their toxins that may transverse the protective cemental layer into the patent dentinal tubules [10]. Furthermore, iatrogenic removal of cementum during periodontal treatment, various developmental fissures, grooves and incomplete calcifications on cementum may all permit penetration by bacteria into the underlying dentinal tubules [10].
\nDentin is highly permeable with dentinal tubules as the major channels for diffusion of material across dentin. Bergenholtz and Lindhe [25] reported that the application of soluble material from bacterial plaque readily caused pulpal inflammation, suggesting there was a pathway of communication between the dentinal tubules, periodontium and the pulp. Such findings were again confirmed by Bergenholtz [26], who found that bacterial products applied to exposed dentin initiated inflammatory reactions in the dental pulp whilst occlusion of such exposed dentin had a protective effect with respect to the pulp.
\nThe source of perio-endo infection is no doubt from within the mouth yet there is no comprehensive report on the microbiota involved compare with periodontal or endodontic infection occurring independently. More than 460 bacterial, almost 10 fungal and 1 archaeal taxa [27] plus predominantly herpesviruses detectable at periradicular lesions [28] were reported associated with endodontic infection. Such observations were rather similar to microbiology of periodontitis [29]. Microbiology of failed endodontic treatment [30] and persisting periradicular endodontic infection (i.e. L-phase bacteria) [28], however exhibit unique microbiology. Taking that into consideration, the exact microbiological nature of perio-endo lesion remained to be elucidated.
\nThe primary aim of endodontic treatment is to disinfect the root canal system through chemo-mechanical debridement and cleaning so that the canal space can be freed of infected organic materials and obturated with an inert material [31]. Endodontic failures are caused by inadequate disinfection of the root canal system or reinfection of the root canal system due to failure to obtain a hermetic seal [32]. Endodontic infection may spread to the periodontium leading to perio-endo pathologies.
\nEndodontic failure may be caused by various biological and procedural factors e.g. (i) persistence intra- and extra-canal infection; (ii) inadequate or poorly condensed filling of the canal; (iii) overextensions of root filling materials; (iv) leakage due to inadequate coronal seal; (v) missed and thus undebrided canals; (vi) iatrogenic procedural errors such as poor access cavity design; and (vii) improper instrumentation (inadequate chemo-mechanical cleaning, ledges, perforations, or separated instruments). As it stands, proper access cavity design, thorough chemo-mechanical debridement and complete sealing of the root canal system to obliterate infection and prevent reinfection are key in prevention of endodontic failure.
\nPoor restorations can be a major culprit for periodontal conditions and endodontic failure. Poor contours due to overhanging restorations, which impinge upon and thus violate the biological width, can contribute to localized periodontal defects [33, 34].
\nPoorly adapted restorations predispose to coronal leakage, allowing for recontamination of the root canal system and subsequent endodontic failure [35, 36]. Ray and Trope [36] reported that defective restorations with adequate root fillings had a higher failure rate in comparison to teeth with inadequate root fillings but with adequate restoration [36]. Similarly, a systematic review by Gillen et al. [35] reported that adequate root canal treatment (RCT) and good coronal seal increased the odds for healing of periapical lesions. In cases with adequate root filling-inadequate coronal restoration and inadequate root filling-adequate coronal restoration, poorer resolution of periapical infections are to be expected [35].
\nIn short, sufficient disinfection and filling of the root canal system and a well-adapted coronal restoration which respects the biological width are paramount in ensuring long-term endodontic success and maintenance of a healthy periodontium around the treated tooth.
\nRoot perforation is a mechanical or pathological, communication between the root canal system and the external tooth surface [37]. Misalignment of instruments during endodontic access, negotiation and preparation of the root canals, and preparation of post space can cause iatrogenic perforations. Pathological root perforation, on the other hand, is caused by root resorption and/or caries.
\nIn perforations, bacterial infections emanating from either the root canal or periodontal tissues, or both, could prevent healing and bring about inflammation. Down-growth of the gingival epithelium to the perforation site can follow, resulting in accelerated periodontal breakdown [38]. Ideally, any perforation should be repaired immediately. Treatment outcomes of endodontic perforations at the apical part of roots have been reported to be more successful than those located more coronally [39, 40]. Mineral trioxide aggregate (MTA) is often used for perforation repair [41] as it can stimulate hard tissue deposition [42], is biocompatible [43], provides excellent seal [44] and sets in the presence of moisture [45].
\nDevelopmental malformations both affect the periodontium and complicate conventional RCT. One of the most common dental malformations seen is the palatal-radicular groove, which has a reported prevalence of 4.6% appearing in maxillary incisors [46]. Its presence is a locus of plaque accumulation and provides potential pathway for microorganisms to penetrate into deeper parts of the periodontium, causing local inflammation and subsequent periodontal breakdown. Attachment loss may extend apically until it adversely affects the viability of the pulp, which is typical of the pathogenesis of a primary periodontal lesion with secondary endodontic involvement. RCT may be needed first if the patient complains of toothache. This may then be followed by periodontal surgical debridement or regenerative periodontal therapy when indicated [47].
\nCemental tear is a rare periodontal condition characterized by partial or total separation of the cementum. The detachment normally happens at the cementum-dentin junction predisposing the tooth to plaque-induced periodontitis. Clinically, a cemental tear may present as a localized deep periodontal pocket, with or without other symptoms such as a sinus tract or pain. Probing at the affected site may detect root surface roughness or an obstruction, different to the expected typical tactile sense of calculus [48]. Treatment of cemental tear includes conventional periodontal therapy, combined periodontal and endodontic treatment when pulpal status of the affected tooth is compromised and/or surgery to remove the tear.
\nCervical enamel projections and enamel pearls are development anomalies presenting as ectopic globules of enamel on the root surface. Enamel projections are small continuous or discontinuous extensions of enamel that occur in the molar furcations while enamel pearls are larger masses of enamel that have a predilection for molars [49]. It has been reported that 82.5% of molars with furcation attachment loss exhibited cervical enamel projections [50]. Enamel pearls are a rarity and occur mostly on permanent molars with an incidence rate of 1.1–9.7% [51]. Cervical enamel projections and enamel pearls predispose to periodontitis because Sharpey’s fiber insertion is not developmentally possible, allowing only a hemi-desmosomal attachment, which may be less resistant to periodontal breakdown. Both entities may also prevent effective oral hygiene procedures when exposed to the oral environment and may serve as a nidus for periodonto-pathogenic bacteria to grow and populate their surface [49]. In longstanding conditions, down-growth of epithelial attachment may cause a perio-endo lesion, especially if exposed accessory canals in the furcation area allow bacteria invasion into the pulp [24]. A combination of treatments may be warranted, such as RCT if pulpal symptoms are present, followed by periodontal surgery to recontour locally the affected root to allow for root debridement and to facilitate proper oral hygiene measures and periodontal maintenance measures.
\nDental resorption is the loss of dental hard tissues as a result of resorptive activities by clastic cells (aptly known as odontoclasts) [52]. Root resorption may occur as a physiologic or pathologic phenomenon. Root resorption is classified into two types, external and internal.
\nExternal inflammatory resorption (EIR) is often a result of root avulsion injuries [53]. Traumatic dental injuries (e.g., intrusion, lateral luxation, and avulsion) and subsequent replantation often result in contusion injuries to the periodontal ligament (PDL). Damage to the pre-cementum, with a resultant breach in its integrity, is the precipitating factor in all types of external resorption [53]. In the wound healing process that follows, necrotic PDL tissues, damaged cementum and even root dentin may be actively removed by macrophages and osteoclasts, although the underlining mechanism is still unclear [52].
\nThe diagnosis of EIR in clinical situations is often based on radiographic findings [54]. However, in two-dimentional radiographic imaging EIR may be obscured by overlapping images, or may not detectably show early signs of EIR, resulting in late diagnosis of EIR. Chronic inflammation seen in periodontal disease has been regarded as a cause for root resorption [55, 56], and such resorptive processes are associated with the severity of periodontitis [55]. The exact mechanism of periodontal disease-associated resorption is not known, but such a process may be a sequela of tooth mobility due to attachment loss [55]. When mobile teeth are subjected to occlusal forces, traumatic assault of the radicular surface may ensue, causing formation of cemental tears or lesions which may become colonized by odontoclastic cells or even periodontal pathogens that may resorb the root [55].
\nTreatment of EIR is based on effective removal of the cause, which is to institute a RCT with removal of the infected necrotic pulpal tissue [57]. Although the treatment of such lesions in periodontal disease is inconclusive, conventional mechanical debridement [56] may suppress inflammation and arrest the resorptive process. The earlier EIR is diagnosed and treated, the better the prognosis is for the affected tooth [58].
\nExternal cervical resorption (ECR) is a form of root resorption that originates on the external root surface but may invade root dentin in any direction and to varying degrees. ECR generally develops immediately apical to the epithelial attachment to the tooth. However, in teeth that have developed gingival recession and lost periodontal support and/or have developed a long junctional epithelium, the resorptive defect may arise at a more apical location [59]. The difference between EIR and ECR is that the pulp remains vital in ECR lesions unless the lesion is extensive and erodes into the pulpal space, while EIR always presents with necrotic pulp with or without any periapical lesion.
\nThe exact etiology and pathogenesis of ECR have not been fully elucidated but may be regarded as the same for EIR. Infected or denuded cementum surfaces allow binding of multinucleated clastic cells which perpetuate the resorptive process [52]. Orthodontic treatment, dental trauma, oral surgery, periodontal therapy, bruxism, delayed eruption, and dental developmental defects were all identified as potential predisposing factors to ECR [60, 61]. In patients with periodontal disease, ECR may occur if the root-protective junctional epithelium (JE) did not develop. In such instances periodonto-pathogen initiated inflammation and dietary acid may extend into the root surfaces to cause ECR [56]. Although not fully understood, such a situation may explain why resorption occurs only in the cervical region, where JE is absent and dietary acid easily gains access and may accumulate over a long period.
\nThe clinical features of ECR may vary depending on etiology. However, the process is very often quiescent and asymptomatic initially. Its diagnosis is commonly made from a chance radiographic finding. A pink or red discoloration may later develop at the cervical region due to fibrovascular granulation tissue occupying the resorptive defect [59]. Inflammatory periodontal destruction may occur in the region of the resorption, resulting in a periodontal pocket that bleeds profusely on probing.
\nIn recent years, CBCT has allowed three-dimensional assessment of the nature, position, and extent of resorptive defects, eliminating diagnostic confusion and providing essential information about the restorability and subsequent management of affected teeth [62, 63, 64]. A CBCT scan (at the smallest voxel size – 0.2 mm) provides a more site-focused and clearer radiographic image [65], thus reducing the need for exploratory treatment (usually surgical exploration), allowing timely intervention and reduced patient morbidity.
\nThe fundamental treatment objectives in ECR are to access and excavate the resorptive defect (usually by raising a mucoperiosteal flap), halt the resorptive process (through application of 90% trichloroacetic acid), restore the hard tissue defect [66], and regular monitoring of the affected tooth for ECR recurrence, and the same for all other teeth which may be predisposed to the same resorptive event. This is especially true for ECRs related to periodontal diseases as multiple ECRs may occur in the same patient [56]. In cases where perforation of the root canal wall has occurred, RCT should be carried out as soon as possible to avoid pain. In periodontal disease-associated ECR, treatment was primarily aimed at suppressing periodontal pathogens through mechanical debridement, oral hygiene instruction and systemic antibiotics. This was supplemented with diet counseling and monitoring to lower the patients daily acid intake. High acidic intake may have contributed to the initiation of the resorptive process by retarding the proliferative capacity of the protective junctional epithelium [56].
\nA vertical root fracture (VRF) is a longitudinally oriented complete or incomplete fracture initiated in the root at any level and is usually directed buccolingually [67]. The diagnosis of a VRF is somehow difficult in the early phase with patients complaining of dull pain, tooth sensitivity and discomfort while chewing. Early detection of VRF is unlikely radiographically due to various obstructions and overlapping structures, making proper diagnosis difficult. In of long-standing VRFs, a sinus tract may develop at a location more coronal than a sinus tract associated with chronic apical abscess [68]. This hints that the source of infection is not likely from an apical lesion [69, 70]. A deep, narrow, isolated periodontal pocket may be present, which is usually pathognomonic of a VRF. Radiographically, a typical J-shaped or halo radiolucency, with bone loss seen apically and extends alongside the involved root is highly indicative of VRF [71].
\nOver time, the pocket along the fracture line, which was initially tight and narrow, may become wider and easier to detect. When the fracture line propagates coronally, extending to the cervical root area, bacteria may penetrate and biofilm can attach along the fracture line, triggering local host immune response which destroys the local periodontium. The fracture line allows the leakage of oral bacteria into the clean and previously sealed root canal system causing contamination. As reported by Tamse et al. [68], a typical VRF pocket could be observed in 67% of the cases. In periodontitis patients, vertical root fractures and cracks may serve to communicate the dental pulp with the periodontium. If the periodontium is infected or inflamed, pulp necrosis may ensue due to bacterial and bacterial product dissemination through such crevices [72].
\nTreatment for VRF differs greatly. VRF does not usually respond to non-surgical RCT or retreatment or to periodontal treatments instituted. In most cases, extraction of the tooth, especially for single-rooted teeth, is required. As for multi-rooted teeth, a root-resective approach may sometimes be considered.
\nUntreated periodontal disease may progress and cause extensive damage to the tooth supporting structures. As the disease extends along the root surface, infection and/or inflammation can spread through the various communications between the pulp and the periodontium [28] until periodontal disease progression reaches the apical foramen leading to a primary periodontal lesion with secondary endodontic involvement [4]. Classification and management of such lesions will be discussed in the segments below.
\nMany classifications for perio-endo lesions have been suggested [4, 72, 73, 74]. However, the proposed classification by Simon et al. [4] is still espoused by many, despite more rational later classifications, for many cases of perio-endo infections, and shall form the framework for the following discussion below.
\nA necrotic pulp with its infected root canal system elicits inflammation of the adjacent periodontium through leaking of bacteria and bacterial by-products through the apical foramen and/or lateral canals causing tooth-supporting bone destruction [4, 72]. In multi-rooted teeth, infection from the apical foramen or the numerous accessory canals located in the molar bifurcation area, may track into the bifurcation area giving a radiographic and often clinical appearance of periodontal furcation involvement [21]. To consider solely endodontic lesions as having a component attributable to periodontitis is a diagnostic and conceptual error.
\nAs such, when differentiating endodontic or periodontal lesions, one should be suspicious of a pulpally/endodontically induced lesion when the crestal bone levels on the mesial and distal aspects of the offending tooth appear relatively normal radiographically, despite a radiographically evident furcation radiolucency, and when clinical attachment loss is localized. Moreover, when the pulp is non-responsive to sensibility testing, it is likely that a necrotic pulp may be the infectious source. Adequate RCT with adequate coronal restoration should usually resolve a primary endodontic lesion without any periodontal therapy, for such lesions are solely endodontic in origin. If solely affected by pulpal pathology, such teeth are only endodontically involved, and the so-called “primary endodontic lesion” is solely an endodontic lesion, and thus really should not be a component of any perio-endo classification. Figure 1 illustrates a pure endodontic lesion managed by endodontic retreatment alone.
\nEndodontic lesion managed by endodontic retreatment. (A) Periapical radiograph of previously root treated tooth 31 exhibiting a large periapical lesion and infection draining through buccal gingival sulcus; (B) retreatment of 31 and RCT of a non-vital 32 completed; (C) radiograph of 31 and 32 showing bone fill 6 months post treatment.
Over time, an untreated primary endodontic lesion may result in secondary consequential periodontal breakdown, which, if this reaches the gingival sulcus or a periodontal pocket, may become infected by periodonto-pathogens which subsequently trigger further periodontitis-associated periodontal tissue destruction, pocket formation, crestal bone loss and plaque (and calculus) contamination of root surfaces.
\nA tooth so affected requires both endodontic and periodontal treatments. In general, healing of tissues damaged by infection from the pulp can be anticipated after adequate RCT. The prognosis of the tooth will then largely depend on the outcome of periodontal therapy [4].
\nPure periodontal lesions are bacterial-induced inflammatory destructions of the tooth supporting apparatus due to periodonto-pathogens [75]. Diagnosis is based on periodontal examination such as probing pocket depths at 6 sites of each tooth, plaque accumulation and gingival bleeding scores [75, 76], on teeth having normal pulpal sensibility test outcomes. Teeth affected by solely periodontitis, which should respond to adequate periodontal therapy alone, are not endodontically involved.
\nIn periodontitis, probing usually reveals plaque and calculus of varying quantity and quality along the root surface. In periodontitis many teeth are usually. The pulp typically responds positively to endodontic sensibility tests unless periodontitis has progressed towards the root apex. Prognosis of purely periodontally affected teeth depends largely upon the amount of bony destruction, the overall management of the patient, including non-surgical and surgical periodontal therapy, practice of adequate oral hygiene measures and adherence to supportive periodontal care [76, 77]. Once more, if a tooth is affected by only periodontitis which would respond to adequate periodontal treatment alone, then it is free from any endodontic involvement, and as such the so-called “primary periodontal lesion” should not form any part of a classification of perio-endo lesions.
\nIf periodontitis progresses apically along the root surface, bacterial infiltrates from the periodontium may penetrate the pulp through exposed accessory and lateral canals, canaliculi of the furcation area, and eventually the apical foramen [72]. Pulpal necrosis can also result from periodontal procedures where the blood supply, through an accessory canal or the apex is severed during instrumentation. Lateral canals and dentinal tubules may be exposed to the oral environment during periodontal treatment allowing microorganism to pass freely to, or be pushed into, the pulpal tissue space [4].
\nPrimary periodontal lesions with secondary endodontic involvement differ from primary endodontic lesion with secondary periodontal involvement only by the temporal sequence of the disease processes. Regardless of the primary cause of disease, RCT should precede periodontal therapy to prevent excessive removal of the protective root cementum and to alleviate any pulpal pain [5, 9, 22]. The tooth prognosis depends on adequate endodontic therapy, adequate coronal restoration and continuing periodontal care subsequent to endodontic therapy. The sequencing of treatment for both primary endodontic with secondary periodontal lesions and primary periodontal with secondary endodontic lesions is basically the same, so there is not a therapeutic distinction to be drawn from the differentiation between these two types of both periodontal and endodontic lesions affecting a tooth.
\nTrue combined lesions occur where a primary endodontic lesion exists on a tooth that is also affected by periodontitis. These lesions are created when an infected periodontal pocket progresses apically to join with the endodontic lesion progressing coronally. Once the endodontic and periodontal lesions coalesce, they may be clinically and radiographically indistinguishable. The degree of attachment loss is usually quite substantial and the prognosis of such lesion is often very guarded [4].
\nIn most cases, apical healing is often evident following successful endodontic treatment. The periodontal lesion, however, should respond well to adequate periodontal treatment and the prognosis may well depend on the severity of the periodontitis-induced periodontal attachment loss and the extent and pattern of alveolar bony destruction. The radiographic appearance of combined endodontic–periodontal disease may be similar to that of a VRF [4, 78].
\nThe primary endodontic lesion and the primary periodontal lesion are solely endodontic or periodontal in origin and should not be confused as perio-endo lesions where both entities are assumed to be associated with one another. To clarify such relationships, Abbott and Salgado [11] proposed a classification that limits the diagnosis of perio-endo lesions to teeth that have both endodontic and periodontal diseases occurring simultaneously. They proposed that such teeth should be classified into:
Concurrent endodontic and periodontal diseases without communication: Implying that a tooth has an infection from the root canal system and concomitant alveolar bone loss due to periodontal disease but the periapical and periodontal lesions do not communicate with each other.
Concurrent endodontic and periodontal diseases with communication: Such a diagnosis applies to a tooth that has an infection from the root canal system and concomitant alveolar bone loss due to periodontal disease and the periapical and periodontal lesions communicate with each other. Radiographically, the periapical radiolucency and the marginal periodontal bone loss appear as one continuous radiolucent lesion.
Al-Fouzan [72] in their discussion on perio-endo lesions agreed largely with the classification by Simon et al. [4] but proposed a modification to the primary endodontic lesion. They classified an endodontic lesion with a deep narrow probing defect as “retrograde periodontal disease”, with two subdivisions:
Primary endodontic lesion with drainage through the periodontal ligament: Which applies to an infected tooth with an apical lesion that drains coronally through a sinus tract that tracks along the periodontal ligament, mimicking a periodontal defect. There is usually a single deep and narrow periodontal pocket which heals upon endodontic treatment alone.
Primary endodontic lesion with secondary periodontal involvement: Such lesions exhibit extensive periodontal destruction as a result of drainage of infection from a necrotic root canal system. As the chronic communication persists, plaque and calculus accumulate within the periodontal pocket and contribute to the advancement of periodontal disease, necessitating periodontal treatment.
Al-Fouzan [72] also added an additional classification termed “iatrogenic periodontal lesions” which included: root perforation, coronal leakage, dental injuries or trauma, damage from chemicals used in dentistry and vertical root fractures. Although such lesions are not exactly periodontal lesions, such a classification allowed separate definition of perio-endo pathologies associated with trauma or iatrogenic injuries to the root surface itself. This was important as extensive damage to the root greatly diminishes a tooth’s long-term prognosis. This distinction may aid clinicians in identifying perio-endo lesions with direct and extensive damage to the root surface as opposed to lesions initiated by root canal infections and/or periodontal infections. Perio-endo lesions arising from root canal and/or periodontal infections are basically inflammatory lesions initiated by a wide array of microbiota such as bacteria, viruses or fungi. These are usually presented clinically without detectable damage to the root itself. Such lesions are treated differently from those with significant root damage and will be discussed below.
\nEvidently, various opinions and controversies have emerged over the classification of perio-endo lesions. Future research or discussion may bring about a more comprehensive classification for such lesions that can clearly define the etiology of such pathologies and serve as a guide to adequately treat them.
\nCombined perio-endo lesions are a challenge to manage. RCT, or at least its initiation with mechanical and chemical cleaning of the pulp canal spaces, and effective intra-canal medication, is usually advocated as the first step in treatment of teeth with combined perio-endo lesions presenting with increased PPD and for teeth are unresponsive to pulp sensibility testing. Non-surgical periodontal therapy can proceed. Once RCT has been completed, adequate time for healing of the endodontic lesion should be given before further advanced periodontal therapy is considered [9]. Treatment modalities aimed at removal of bacterial irritants result in tooth prognosis which has been shown to improve over time [47]. This section summarized the treatment sequence for perio-endo lesions (Figure 2).
\nFlow chart summarizing treatment sequence for perio-endo lesions.
In the management of perio-endo lesions, it is important to recall that infected or necrotic pulps may lead to a narrow sinus tract undistinguishable clinically from a periodontal pocket. Because the primary cause of such lesions is pulpal in origin, the indicated treatment is solely RCT followed by adequate coronal seal, with long-term follow-up and monitoring to assess healing.
\nSimilarly, if a vital tooth affected by solely periodontal disease develops mild pulpal symptoms, periodontal treatment should be the only intervention, followed by long-term follow-up. This will allow the mild and usually reversible inflammatory reaction of the pulp (which may transiently increase after periodontal therapy) to resolve as the vital pulp resists the spread of inflammation from the periodontal lesion [12].
\nWith regards to concurrent perio-endo infections, although these separate entities may not be communicating, RCT should be carried out, or at least initiated, first to eliminate pulpal infection and relieve pain. This may then be followed by root surface debridement. Such a treatment sequence will allow removal of infectious source from the pulp and control of any possible communication between the infected root canal system and the adjacent periodontium. With this, even if the protective cementum layer is removed during root surface debridement, there should be no pulpal infection that can spread towards the periodontium through open dentinal tubules or accessory canals [11, 12]. Such a treatment philosophy is applied to true perio-endo lesions as well, to allow the affected tooth to undergo infection control in its entirety, sequentially and as effectively as possible [12].
\nIndeed, in any patient with periodontal disease, management should include plaque control, non-surgical scaling and root debridement; periodontal surgery (with or with regenerative periodontal therapies) when indicated; and subsequent supportive periodontal care (SPC) [76, 79]. SPC should allow any teeth with pathologies, periodontal, endodontic or combined, to be well maintained within the oral cavity in the long term.
\nConventional non-surgical periodontal and endodontic therapy may be predictably used to treat mild to moderate bony defects caused by perio-endo lesions. However, these non-surgical therapies alone might be inadequate for the treatment of lesions characterized by deep pockets, or wide circumferential apical defects caused by non-healing endodontic lesions, previous endodontic surgery [80], or those with substantial root surface damage such as root fracture of resorption. An endodontic lesion may be considered non-healing if the periapical lesion increases in size or remains unchanged after RCT. A decision to provide alternative treatment modalities will depend largely on the signs and symptoms experienced by the patient and judgment of the treating clinician, as periapical lesions can take up to four years [32] or longer [81] to heal. Surgical options for perio-endo lesions can be divided into surgical debridement, periodontal- or root- resective, or regenerative, approaches. The extent of periodontal tissue destruction or the failure of adequately delivered treatment to resolve the lesions, or any component thereof, may leave tooth extraction as the only practical treatment option.
\nRoot resection is the removal of a root (or roots, or root with coronal tooth structure) along with accompanying odontoplasty, before or preferably after endodontic treatment. Such tooth respective modalities are advocated to treat specific non-furcation and furcation defects that unlikely to be managed by non-surgical or surgical debridement alone [82]. The indications for root resection include root fracture, perforation, root caries, dehiscence, fenestration, external root resorption involving one root, incomplete endodontic treatment of a particular root, severe periodontitis affecting only one or two roots with at least one good sized root with proper/sufficient periodontal support to remain [83], or and severe grade II or grade III furcation involvement of multi-rooted teeth in the treatment of which clinicians attempt to create ‘single rooted’ situations to remove affect root(s) and to facilitate oral hygiene and SPC measures [84, 85].
\nFactors such as occlusal forces, tooth restorability, residual periodontal support and strategic value of the remaining root(s) should be taken into consideration during the planning stage before treatment. Proper reshaping of the occlusal table and appropriate restoration of the clinical crown are essential [83]. Additionally, the root surface at the site of the amputation must be recontoured after removal of the root stump to allow reestablishment of soft and hard tissue morphology favorable for oral hygiene measures by the patient and SPC measures by treating clinicians [86].
\nHemisection is the surgical separation of a multirooted tooth. This is usually only a treatment option for mandibular molars with severe furcation involvement and periodontal attachment loss having affected one root more severely than the other (Figure 3). The tooth was sectioned through the furcation, and the respective root and associated portion of the crown may be removed while another moiety is retained [87]. In most instances, an elective RCT should be performed before or as soon as possible after the hemisection to avoid any future pulpal complications. Hemisection allows retention of natural tooth structure, especially the root, which helps preserve surrounding alveolar bone, and may facilitate the placement of fixed prostheses [87].
\nManagement of a mandibular left first molar with severe furcation involvement and periodontal attachment loss. (A) Radiographic bone loss observable at distal root of a non-vital 36; (B) RCT was completed and 36 was hemisected distally; (C) 36 was subsequently crowned to coronally seal the treated root canal, re-establish occlusion and prevent further mesial drift of the second molar.
The restorative aspects of the tooth to be so treated must be carefully assessed and integrated into the anticipated surgical procedure to ensure proper positioning of restorative margins relative to the osseous crest, and also to manage the anticipated changes in occlusal relationships and masticatory forces. In certain occasions, splinting of a resected tooth to neighboring teeth or the use of such teeth as abutments for fixed partial dentures may confer some reinforcement towards its long-term survival [83]. Although factors such as older age at time of resection, grade II mobility or above, and reduced pre-operative radiographic bone heights around roots seem to reduce the survival of resected teeth, the major cause of failure of resective procedures is often due to endodontic failure or vertical root fractures [88]. This is especially true if periodontal treatment had been properly carried out and the patient adheres to strict SPC [83, 88]. In most situations, the residual periodontal support of the treated tooth dictates the prognosis of the tooth. However, teeth with reduced periodontal support may still be maintained if proper SPC is provided [76, 89].
\nRegenerative therapy has been shown to yield greater attachment gain and re-establish more favorable tissue morphology for oral hygiene measures compared to conventional periodontal therapy [90]. Pre-surgical assessment includes assessment of the pulp status and the severity of periodontal destruction. Once the therapeutic prognosis for the periodontal regenerative procedure is determined to be favorable, endodontic therapy is provided and the endodontic lesion is allowed to heal. Unsatisfactory healing after RCT might be further addressed with a surgical endodontic therapy approach (apicectomy) [78]. After a successful RCT, tooth mobility is reassessed to determine the necessity for splinting, as tooth mobility may reduce the success of regenerative therapy [91]. The intrasurgical assessment includes morphology of the periodontal defect, material of choice to manage the defect, control of patient’s oral hygiene, wound and tooth stabilization [78]. The defect, patient, and surgery-specific factors associated with favorable periodontal regeneration are [80]:
Defect considerations: Deep (≥4 mm), narrow (<45 degrees), vertical, two to three wall defects with no/minimal furcation involvement, adequate soft tissue thickness (>1.1 mm) and keratinization (2 mm).
Patient considerations: Good oral hygiene, compliance towards periodontal care, abstinence from smoking/non-smoking and good systematic health/properly controlled systemic conditions.
Surgical considerations: Atraumatic incisions and flap elevation, primary closure, passive wound tension, uncontaminated wound during surgery (and post-surgical healing) and no occlusal trauma
In perio-endo lesions, regenerative periodontal therapies, such as use of biologically active products or guided tissue regeneration (GTR), may be used to promote periodontal regeneration and crestal intra-osseous defect bone-fill after endodontic treatment. In GTR, a barrier membrane is used to prevent contact of connective tissue with the osseous walls of an intra-osseous defect, to protect the underlying blood clot and to encourage growth of key tissues, while excluding unwanted cells such as epithelial cells [80]. When the intra-osseous defect is large, bone substitutes may be placed in the defect to support the overlying membrane and to maintain a space in which healing may occur [80]. Sometimes both root-resective and regenerative treatment may be carried out simultaneously to retain a tooth in function. Figure 4 shows treatment of an upper first molar with a root fracture.
\nPeriodontal surgical management of an upper left first molar with a root fracture. (A) Radiograph of root treated 26 with suspected mesio-buccal root fracture; (B) intra-operative view of 26 confirming initial diagnosis; (C) 26 MB root was resected and the defect regenerated with xenograft and a collagen barrier membrane. Radiograph taken at 6 months post treatment.
An in-depth understanding of the biology underlying perio-endo inter-relationships guides a clinician in diagnosing and subsequently deriving a sensible and timely treatment plan. Conventional endodontic and periodontal therapy have been shown to be successful in managing such lesions [47] with endodontic therapy, or at least its initiation, being the first line of treatment in most cases [9]. The use of regenerative approaches to manage perio-endo lesions has advantages especially in terms of enhanced attachment gain and better long-term outcome of treated teeth. Various other treatment modalities for managing the periodontal component of perio-endo lesions, such as the application of enamel matrix derivatives [92] or platelet-rich fibrins [93] may offer good results. However, more research is warranted in this field with hope that retention of perio-endo involved teeth may become more predictable in the near future.
\nThe work described in this chapter was substantially supported by the Young Researcher’s Incentive Grants (GGPM-2016-062 and GGPM-2017-109), The National University of Malaysia, and the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 772110 M).
\nThe authors declare no conflict of interest.
Ionic liquids (ILs) may be defined as “ionic materials,” with low melting points (below 100°C) generally composed of inorganic or organic anions paired with large, usually asymmetric organic cations. Ionic liquids (ILs) pose a plethora of unique physicochemical and solvation characteristics that can be tuned for specific applications and often producing interesting results when employed instead of traditional molecular solvents [1, 2]. In addition, most ILs show negligible vapor pressure [3] as well as high thermal stability [4, 5, 6]. Due to these attractive features they are termed as neoteric solvents or green solvents. In recent years, ILs were extensively studied for their wide electrochemical window, high ionic conductivity [7] and a broad temperature range of the liquid state. Moreover, the physical properties of ILs including density, melting point, polarity, Lewis acidity, viscosity and enthalpy of vaporization can all be tuned by changing their cation and anion pairing [8]. IL-based solvent system typically exhibits enhanced reaction kinetics resulting in the efficient use of time and energy [1]. Due to these properties, ILs are treated as a new generation of solvents for catalysis, ecofriendly reaction media for organic synthesis and a successful replacement for conventional media in chemical processes [1, 9]. Recently, many researchers have focused on the synthesis of new ionic liquids called functionalized ionic liquids (FILs) with different functional groups in the cationic moiety [10, 11, 12, 13, 14, 15]. Such functionalization of the cation can easily be done in a single reaction step and thus both the cationic and anionic moieties of the FILs can be altered as required for specific applications like increased catalytic stability and reduced catalyst leaching, etc. [16, 17].
\nOf note Schiff base being a salient class of multidentate ligand has played a key role in coordination chemistry. They exhibit varied denticities, chelating capability [18, 19, 20], functionalities [21] and diverse range of biological, pharmacological and antitumor activities. Schiff-bases containing hetero-atom such as N, O, and S are drawn special interest for their varied ways of coordination with different transition metal ions and having unusual configurations [22, 23, 24]. The present chapter describes the syntheses and physicochemical characterizations of an IL-supported Schiff base, 1-{2-(2-hydroxy-5-nitrobenzylideneamino)ethyl}-3-ethylimidazolium tetrafluoroborate and its Co(II), Ni(II) and Cu(II) complexes. The ligand and its metal complexes were screened for their in vitro antibacterial activities against Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Enterobacter aerogenes and Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. The complexes and the ligand were found most effective against the tested Gram-negative/positive bacteria.
\nAnalytical grade chemicals were used for synthesis without further purification. 1-ethyl imidazole, 2-bromoethylamine hydrobromide, 5-nitro-2-hydroxybenzaldehyde and NaBF4 (sodium tetrafluoroborate) were purchased from Sigma Aldrich, Germany. Metal acetates and other reagents were used as obtained from SD Fine Chemicals, India. CH3OH, petroleum ether, CHCl3, DMF and DMSO were used after purification by standard methods described in the literature. FT-IR spectra were recorded by KBr pellets on a Perkin-Elmer Spectrum FT-IR spectrometer (RX-1). 1H NMR and 13C NMR spectra were recorded on a FT-NMR (Bruker Avance-II 400 MHz) spectrometer by using D2O and DMSO-d6 as solvents. Powder X-ray diffraction (XRD) data were obtained on INEL XRD Model Equinox 1000 using Cu Kα radiation (2θ = 0–90°). Elemental microanalysis (CHN analysis) was performed on Perkin-Elmer (Model 240C) analyzer. Metal content was obtained from AAS (Varian, SpectrAA 50B) by using standard metal solutions procured from Sigma-Aldrich, Germany. ESI-MS spectra were obtained on a JMS-T100LC spectrometer. The purity of the synthesized products was confirmed by thin layer chromatography (TLC) Merck 60 F254 silica gel plates (layer thickness 0.25 mm) and the spots were visualized using UV-light. The UV-visible spectra were obtained from JascoV-530 double beam spectrophotometer using CH3OH as solvent. Specific conductance was measured at (298.15 ± 0.01) K with a Systronic conductivity TDS-308 metre. Magnetic susceptibility was measured with a Sherwood Scientific Ltd. magnetic susceptibility balance (Magway MSB Mk1) at ambient temperature. The melting point of synthesized compounds was determined by open capillary method. Antibacterial activity (in vitro) of the synthesized ligand and complexes were evaluated by well diffusion method against six bacterial strains (two Gram-positive and four Gram-negative). The bacterial strains were obtained from MTCC, Chandigarh, India.
\nThe FIL was synthesized by following a literature procedure [25]. [2-aeeim]BF4 was obtained as yellow oil; (98 mg, 70%); 1H NMR (400 MHz, D2O, TMS): δ = 1H NMR (400 MHz, D2O): δ = 3.63 (m, 2H, NH2▬CH2), 4.16 (s, 3H, CH3), 4.49 (t, 1H, N▬CH2), 4.56 (t, 1H, N▬CH2), 7.40 (s, 1H, NCH), 7.50 (s, 1H, NCH), 8.61 (s, 2H, NH2), 8.87 (s, 1H, N(H)CN); IR (KBr): ʋ = 3447, 3086, 2896, 1626, 1452, 1084. ESI-MS (m/z) calc for [C7H14N3]+: 140, found: 140 [M-BF4]+. Anal. calcd. for C7H14F4N3B: C 37.04, H 6.22, N 18.51, found: C 36.99, H 6.14, N 18.43.
\n5-nitro-2-hydroxybenzaldehyde (1.67 g, 10 mmol) and [2-aeeim]BF4 (2.27 g, 10 mmol) were taken in methanol and stirred at 25°C for 4 h. After completion of reaction, the product was diluted using ethanol. The precipitate was filtered, washed with cold EtOH and dried properly to collect the expected ligand as a yellowish brown solid; (282 mg, 75%). mp. 95–97°C. 1H NMR: (400 MHz, DMSO-d6, TMS): δ = 3.36 (q, 2H, N▬CH2), 3.60 (s, 3H, CH3), 3.92 (t, 2H, N▬CH2), 4.60 (t, 2H, N▬CH2), 7.44 (s, 1H, NCH), 7.52 (s, 1H, NCH), 7.53 (s, 1H, N═CH), 7.61–7.59 (m, 3H, Ar-H), 8.65 (s, 1H, N(H)CN), 8.88 (s, 1H, OH). 13C NMR: (400 MHz, DMSO-d6, TMS): δ = 159.76, 138.43, 134.08, 130.47, 130.31, 123.89, 119.80, 118.65, 110.65, 39.86, 39.65, 39.24, 39.03 and 38.82. IR (KBr): ʋ = 3448 (O▬H), 3071, 1664 (C═N), 1343 (N▬O), 1293 (C▬O), 1095 (B▬F). UV/vis (methanol, λmax): 206, 234, 306 nm; ESI-MS (CH3OH, m/z) [M-BF4]+ calcd. for [C14H17N4O3]+: 289, found; 289. Anal. calcd. for C14H17N4O3BF4 (376): C 44.71, H 4.56, N 14.90. found: C 44.64, H 4.49, N 14.83.
\nTo an ethanolic solution of ligand, LH (2c) (0.376 g, 1 mmol) in round bottomed flask, metal acetate salt Co(II), Ni(II) and Cu(II), viz., (0.5 mmol) dissolved in ethanol was added and the reaction mixture was refluxed for 12 h until the starting materials were completely consumed as monitored by TLC. On completion of the reaction, solvents were evaporated and the reaction mixture was cooled to room temperature. The precipitate was collected by filtration, washed successively with cold ethanol (10 mL × 3). Finally it was dried in vacuum desiccators to obtain the solid product. The complexes were soluble in N,N-dimethylformamide, dimethylsulfoxide, acetonitrile, methanol and water. A schematic representation of the syntheses is given inFigure 1.
\nSynthesis of Ionic liquid supported Schiff base (2a) and its metal complexes 3a, 4a and 5a from 2a.
Brown solid; (0.54 g, 67%), decomposes at ~293°C. IR (KBr): ʋ = 3386 (O▬H), 1648 (C═N), 1332 (N▬O), 1177 (C▬O), 1106 (B▬F), 651 (M▬O), 510 (M▬N). UV/vis (methanol, λmax/nm): 227, 246, 358. ESI-MS (CH3OH, m/z) [M-2BF4]+ calcd. for [C28H32CoN8O6]+: 635, found: 635; anal. calcd. for C28H36CoB2F8N8O8 (809): C 41.56, H 3.99, N 13.85, Co 7.28, found: C 41.36, H 3.71, N 13.55, Co 7.12.
\nLight green solid; (0.56 g, 69%), decomposes at ~293°C. IR (KBr): ʋ = 3396 (O▬H), 1637 (C═N), 1330 (N▬O), 1172 (C▬O), 1102 (B▬F), 646 (M▬O), 526 (M▬N). UV/vis (methanol, λmax/nm): 220, 340, 400. ESI-MS (CH3OH, m/z) [M-2BF4]+ calcd. for [C28H32NiN8O6]+: 634, found: 634; anal. calcd. for C28H36NiB2F8N8O8 (809): C 41.57, H 3.99, N 13.85, Ni 7.26, found: C 41.22, H 3.63, N 13.46, Ni 7.11.
\nDark green solid; (0.57 g, 70%), decomposes at ~295°C. IR (KBr): ʋ = 3429 (O▬H), 1656 (C═N), 1334 (N▬O), 1175 (C▬O), 1103 (B▬F), 633 (M▬O), 471 (M▬N). UV/vis (methanol, λmax/nm): 226, 244, 354. ESI-MS (CH3OH, m/z) [M-2BF4]+ calcd. for [C28H32CuN8O6]+: 634, found: 634. Anal. calcd. for C28H36CuB2F8N8O8 (813.76): C 41.33, H 3.96, N 13.77, Cu 7.81, found: C 41.12, H 3.61, N 13.46, Cu 7.61.
\nThe synthesized ligand (2a) and complexes (3a, 4a and 5a) were screened against the Gram-negative bacteria (E. coli, P. aeruginosa, P. vulgaris and E. aerogenes) and Gram-positive bacteria (S. aureus and B. cereus) strains. The tests were performed using agar disc diffusion method [26]. The nutrient agar (Hi-Media Laboratories Limited, Mumbai, India) was put in an autoclave at 121°C and 1 atm for 15–20 min. The sterile nutrient medium was kept at 45–50°C and then 100 μL of bacterial suspension containing 108 colony-forming units (CFU)/mL was mixed with sterile liquid nutrient agar and poured into the sterile Petri dishes. All the stock solutions were made by dissolving the compounds in dimethylsulfoxide (DMSO). The concentrations of the tested compounds were 10, 20, 30, 40 and 50 μg/mL. The tested microorganisms were grown on nutrient agar medium in Petri dishes. The samples were soaked in a filter paper disc of 1 mm thickness and 5 mm diameter. The discs were kept on Petri plates and incubated for 24 h at 37°C. The diameter of the inhibition zone (including disc diameter of 5 mm) was measured. Each experiment was carried out three times to minimize the error and the mean values were accepted.
\nAll the isolated compounds were stable at room temperature to be characterized by different analytical and spectroscopic methods. The complexes are soluble in N,N-dimethylformamide, dimethylsulfoxide, acetonitrile, methanol and water.
\nThe assignments of the IR bands of the synthesized Co(II), Ni(II) and Cu(II) complexes had been made by comparing with the bands of ligand (LH) to determine the coordination sites involved in chelation. FT-IR spectra of LH (2a) showed a strong broad band at 3448–3071 cm−1; which was due to the hydrogen bonded phenolic group (▬OH) with H▬C(═N) group in the ligand (OH…N═C) [27, 28]. The broad band appeared at 3386–3429 cm−1 for the metal complexes (3a, 4a and 5a) suggested the presence of the solvated water molecules (probably for the presence of ▬NO2 group in the ligand and intrinsic property of the anion tetrafluoroborate) [29, 30, 31]. The band corresponding to the azomethine group (▬C═N) of the ligand was found at 1664 cm−1. This band gets shifted in the range 1637–1656 cm−1 because of coordination of N atom of azomethine linkage to the Co2+, Ni2+ and Cu2+ ions respectively [32]. The band for phenolic C▬O of free ligand was observed at 1293 cm−1 which moved to lower wave number 1172–1177 cm−1 for the complexes (3a, 4a and 5a) upon complexation. This fact established the bonding of ligand (2a) to the metal atoms through the N atom of azomethine and O atom of phenolic group [33]. The bands appeared in the region of 1102–1107 cm−1 for the metal complexes were assigned for B▬F stretching frequency. FT-IR spectra of the LH (2a) and its complexes showed strong bands at 1330–1343 cm−1 which were assigned for the NO2 group [34]. The spectra of the metal complexes exhibited bands at 633–651 and 471–526 cm−1 were attributed to M▬O and M▬N stretching vibrations, respectively [35]. IR spectra are given in Figures 2–8.
\nSEM image of Co(II) complex (3a).
SEM image of Ni(II) complex (4a).
SEM image of Cu(II) complex (5a).
FT-IR spectra of ligand (2a).
FT-IR spectra of Co(II) complex (3a).
FT-IR spectra of Ni(II) complex (4a).
FT-IR spectra of Cu(II) complex (5a).
1H NMR and 13C NMR spectra of Schiff base were recorded in DMSO-d6 (as shown in Figures 9 and 10). 1H NMR spectra of the ligand showed singlet at 7.60 ppm which was assignable to proton of the azomethine linkage (▬CH═N▬) might be because of the effect of the ortho-hydroxyl group in the aromatic ring. A singlet at 8.88 ppm was assigned to hydroxyl proton (▬OH). The downfield shift of the phenolic (▬OH) proton was observed due to intramolecular (O▬H…N) hydrogen bonding in the ligand [36]. 13C NMR spectra of ligand exhibited peaks at δ 159.76 and 138.43 which were detected for the phenolic (C▬O) and imino (▬CH═N) carbon atoms (due to keto-imine tautomerism). The aromatic carbons showed pecks at δ 134.08, 130.47, 130.31, 123.89, 119.80 and 118.65.
\n1H NMR spectra of LH (2a).
13C NMR spectra of LH (2a).
The PXRD analysis of the synthesized compounds was carried out to find whether the particle nature of the samples was amorphous or crystalline. The PXRD spectrum of ligand (LH) exhibited sharp peaks because of their crystalline nature although the spectra of the two complexes did not show such peaks for their amorphous nature (as shown in Figures 11–14). The crystalline sizes were calculated using Debye Scherer’s equation: D = 0.9 λ/βcosθ, where constant 0.9 is the shape factor, λ is the X-ray wavelength (1.5406 Å), β is the full width at half maximum (FWHM) and θ is the Bragg diffraction angle. The experimental average grain sizes of LH and its metal complexes were found to be 31.71 nm (2a), 7.76 nm (3a), 3.26 nm (4a) and 4.52 nm (5a).
\nPXRD spectra of LH (2a).
PXRD spectra of Co(II) complex (3a).
PXRD spectra of Ni(II) complex (4a).
PXRD spectra of Cu(II) complex (5a).
To get information regarding the structure of the synthesized compounds at the molecular level, electrospray ionization (ESI) mass spectrometry was performed using methanol as solvent. Mass-spectra of the LH (2a) had a molecular ion peaks at m/z 289, that corresponds to [M-BF4]+, [M = C14H17N4O2]+. The metal complexes (3a, 4a and 5a) exhibited molecular ion peaks (m/z) at 635 (M = [C28H32CoN8O6]+), at 634 (M = [C28H32NiN8O6]+) and at 639 (M = [C28H32CuN8O6]+) which confirmed their stoichiometry as Co(L)2, Ni(L)2 and Cu(L)2 respectively. The mass spectra of the ligand and complexes were in good agreement with the respective structures as revealed by the elemental and other spectral analyses.
\nThe UV-visible spectra of the Schiff base and its metal complexes (as depicted in Figure 15) were recorded at room temperature using methanol as solvent. The LH (2a) exhibited three absorption bands at 306, 234 and 206 nm due to n → π*, π → π* and transitions involved with the imidazolium moiety, respectively [37, 38]. For the complexes, the bands that appeared below 350 nm were ligand centered transitions (n → π* and π → π*). The Co(II) complex (3a) displayed a band at 354 nm which could be attributed to the combination of 2B1g → 1A1g and 1B1g → 2Eg transitions and supporting square planar geometry [39, 40]. The complex (3a) showed magnetic moment of 2.30 B.M. due to one unpaired electron. The Ni(II) complex (4a) was diamagnetic and the band appeared at around 400 nm due to 1A1g → 1B1g transition is consistent with low spin square planar environment [41]. UV-visible spectra of Cu(II) complex (5a) exhibited d → π* metal-ligand charge transfer transition (MLCT) at the region 358 nm had been assigned to the combination of 2B1g → 2Eg and 2B1g → 2B2g transitions in a distorted square planar geometry. The experimental magnetic moment value for 5a was 1.84 B.M. consistent with the presence of an unpaired electron [42, 43].
\nUV-visible spectra in methanol (concentration of the solutions 1 × 10–4 M): (A) LH (2a); (B) Co(II) complex (3a); (C) Ni(II) complex (4a) and (D) Cu(II) complex (5a).
The molar conductance (Λm) of the metal complexes was determined by applying the relation Λm = 1000 × κ/c, where κ and c stands for the specific conductance and molar concentration of metal complexes respectively. The complexes (1 × 10−3 M) were dissolved in DMF and their specific conductance was measured at (298.15 ± 0.01) K. The molar conductance data was observed as 123, 128 and 131S cm−1 mol−1 for the metal complexes 3a, 4a and 5a respectively indicating their 1:2 electrolytic natures.
\nAntibacterial study of LH (2a) and its complexes was carried out in vitro against the Gram-negative/positive bacterial strains, and the results are displayed in Tables 1 and 2and also in Figure 16. Minimum inhibitory concentration (MIC) was measured by broth micro dilution susceptibility method. No inhibition zone was found for the solvent control (DMSO) for each bacterial suspension. A serial dilution of sample extracts was made in nutrient broth medium. Then 1 mL of standard (0.5 Mc Farland) bacterial suspension was inoculated into each of these tubes. A similar nutrient broth tube without sample extract was also inoculated and used as control. The samples under investigation have shown promising results against the tested bacterial strains. The LH (2a) was most effective against S. aureus only. The Co(II) complex (3a) showed most effectiveness against S. aureus, E. aerogenes. The Ni(II) complex (4a) showed higher activity against E. aerogenes. Although in other cases it showed moderate activity. It was found that Cu(II) complex (5a) was most effective against the tested bacteria. The observation suggested that the chelation could facilitate the capability of the complexes to penetrate bacterial cell membrane [44]. Such a chelation could enhance the lipophilic property of the corresponding metal ions that favors permeation towards the lipid layer of cell membrane. The activity of both the complexes and ligand enhanced as the concentration was increased which were due to the growth of degree of inhibition.
\nSpecimen | \nConcentration (μg/mL) | \n||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E. coli | \nS. aureus | \nB. cereus | \n|||||||||||||
10 | \n20 | \n30 | \n40 | \n50 | \n10 | \n20 | \n30 | \n40 | \n50 | \n10 | \n20 | \n30 | \n40 | \n50 | \n|
LH | \n— | \n6 | \n7 | \n8 | \n12 | \n7 | \n9 | \n10 | \n10 | \n12 | \n— | \n— | \n6 | \n8 | \n12 | \n
Co(II) complex | \n— | \n— | \n6 | \n7 | \n8 | \n6 | \n7 | \n7 | \n9 | \n10 | \n— | \n6 | \n6 | \n8 | \n10 | \n
Ni(II) complex | \n6 | \n7 | \n8 | \n9 | \n9 | \n— | \n— | \n7 | \n8 | \n10 | \n— | \n— | \n6 | \n8 | \n10 | \n
Cu(II) complex | \n8 | \n9 | \n14 | \n15 | \n18 | \n6 | \n8 | \n10 | \n17 | \n17 | \n— | \n— | \n— | \n— | \n7 | \n
Antibacterial activity data of Schiff base (2a) and its metal complexes (3a, 4a and 5a) against E. coli, S. aureus and B. cereus with their minimum zone of inhibition and MIC (μg/mL) mm values.
Specimen | \nConcentration (μg/mL) | \n||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P. aeruginosa | \nP. vulgaris | \nE. aerogenes | \n|||||||||||||
10 | \n20 | \n30 | \n40 | \n50 | \n10 | \n20 | \n30 | \n40 | \n50 | \n10 | \n20 | \n30 | \n40 | \n50 | \n|
LH | \n— | \n6 | \n9 | \n15 | \n16 | \n— | \n6 | \n9 | \n10 | \n14 | \n— | \n6 | \n8 | \n10 | \n13 | \n
Co(II) complex | \n— | \n7 | \n9 | \n10 | \n13 | \n— | \n— | \n— | \n6 | \n7 | \n8 | \n10 | \n13 | \n15 | \n17 | \n
Ni(II) complex | \n— | \n— | \n6 | \n7 | \n9 | \n— | \n— | \n6 | \n7 | \n8 | \n8 | \n10 | \n12 | \n12 | \n16 | \n
Cu(II) complex | \n— | \n6 | \n12 | \n12 | \n14 | \n— | \n7 | \n7 | \n8 | \n16 | \n— | \n— | \n6 | \n7 | \n10 | \n
Antibacterial activity data of Schiff base (2a) and its metal complexes (3a, 4a and 5a) against P. aeruginosa, P. vulgaris and E. aerogenes with their minimum zone of inhibition and MIC (μg/mL) mm values.
Inhibition zones for the LH (2a), Co(II) complex (3a), Ni(II) complex (4a) and Cu(II) complex (5a).
Herein this chapter, new Co(II), Ni(II) and Cu(II) complexes of an ionic liquid-supported Schiff base, 1-{2-(2-hydroxy-5-nitrobenzylideneamino)ethyl}-3-ethylimidazolium tetrafluoroborate were synthesized and characterized by different spectral and analytical techniques. The Schiff base ligand played as a potential bidentate ligand coordinating through the N-atom of azomethine and O-atom of phenolic group to the metal ions and thus formed 1:2 (M:L) complexes. Spectral and magnetic susceptibility data revealed that the ligand was arranged in square planner geometry around the central metal ions. The antibacterial study of the synthesized compounds was performed and metal complexes have exhibited promising activity against the tested bacteria.
\nThe authors are thankful to the Departmental Special Assistance Scheme, under the University Grants Commission, New Delhi (SAP-DRS-III, NO.540/12/DRS/2013) and SAIF, NEHU, Guwahati, India for 1H NMR, 13C NMR, ESI-MS and elemental analysis. Again authors are grateful to Annamalai University, Tamil Nadu, India for PXRD analysis.
\n\n 1-(2-aminoethyl)-3-ethylimidazolium tetrafluoroborate 1-{2-(2-hydroxy-5-nitrobenzylmine) ethyl}-3-ethylimidazolium tetrafluoroborate [Di(1-{2-(2-hydroxy-5-nitrobenzylidene amino)ethyl}-3-ethylimidazolium) Co(II)] tetrafluoroborate [Di(1-{2-(2-hydroxy-5-nitrobenzylidene amino)ethyl}-3-ethylimidazolium) Ni(II)] tetrafluoroborate [Di(1-{2-(2-hydroxy-5-nitrobenzylidene amino)ethyl}-3-ethylimidazolium) Cu(II)] tetrafluoroborate
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\n\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\n\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\n\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\n\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
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