Serum levels of estrogen and bioavailable testosterone (bio-T) in rats.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6183",leadTitle:null,fullTitle:"Selected Topics on Optical Fiber Technologies and Applications",title:"Selected Topics on Optical Fiber Technologies and Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"This book is a collection of contributions by selected active researchers in the optical fiber fields highlighting the design, fabrication, and application of optical fibers and fiber systems and covering various topics such as microstructured optical fibers, polymer fibers, nonlinear effects, optical tweezers, and gyroscopic systems. The goal of the book is to provide an updated overview of the current research trends in the optical fiber fields, serving as a general reference for the recent development in optical fiber technologies, though inevitably many topics are not covered.",isbn:"978-953-51-3814-3",printIsbn:"978-953-51-3813-6",pdfIsbn:"978-953-51-4055-9",doi:"10.5772/intechopen.68456",price:119,priceEur:129,priceUsd:155,slug:"selected-topics-on-optical-fiber-technologies-and-applications",numberOfPages:250,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a093595712f2523164123391d74553c8",bookSignature:"Fei Xu and Chengbo Mou",publishedDate:"February 14th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6183.jpg",numberOfDownloads:13548,numberOfWosCitations:22,numberOfCrossrefCitations:18,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:31,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:71,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2017",dateEndSecondStepPublish:"April 12th 2017",dateEndThirdStepPublish:"July 25th 2017",dateEndFourthStepPublish:"October 7th 2017",dateEndFifthStepPublish:"December 20th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"87032",title:"Prof.",name:"Fei",middleName:null,surname:"Xu",slug:"fei-xu",fullName:"Fei Xu",profilePictureURL:"https://mts.intechopen.com/storage/users/87032/images/5260_n.jpg",biography:"Dr. Fei Xu received his BE degree from the Nanjing University, China, in 2000; MSc degree from the Nanjing University, China, in 2005; and PhD degree in Optoelectronics from the Optoelectronics Research Centre, University of Southampton, UK, in 2008. He is currently a full professor at the College of Engineering and Applied Sciences, Nanjing University, China. His current research interests include the development of novel fiber devices for ultrasmall sensor and laser systems and the optomechanical effect in nanoscale waveguide systems. To date, he has authored or coauthored 8 book chapters, granted more than 30 patents (China and US), and published more than 100 peer-reviewed articles in academic journals in the previously mentioned areas.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Nanjing University",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"206956",title:"Dr.",name:"Chengbo",middleName:null,surname:"Mou",slug:"chengbo-mou",fullName:"Chengbo Mou",profilePictureURL:"https://mts.intechopen.com/storage/users/206956/images/6860_n.jpg",biography:"Prof. Chengbo Mou received the B.Eng. degree from Tianjin University, China, in 2004, the M.Sc. degree the University of St Andrews, U.K., in 2005, and the Ph.D. degree in photonics from Aston University, U.K., in 2012.\nHe has been investigating the design and fabrication of novel fiber grating devices and their applications in fiber lasers and sensors, novel material-based mode locked fiber lasers, polarization dynamics of fiber lasers. He has authored or co-authored over 100 papers in international journals and conferences.\nProf. Mou is now with the Key Laboratory of Specialty Fiber Optics and Optical Access Networks at Shanghai University, China. He was a recipient of Young Eastern Scholar Fellowship from Shanghai in 2015 and a recipient of Young Thousand Talent Plan Award from China.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1226",title:"Optoelectronics",slug:"optics-and-lasers-optoelectronics"}],chapters:[{id:"58873",title:"Fabrication and Sensing Applications of Special Microstructured Optical Fibers",doi:"10.5772/intechopen.70755",slug:"fabrication-and-sensing-applications-of-special-microstructured-optical-fibers",totalDownloads:1345,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"This chapter presents the fabrication of the special microstructured optical fibers (MOFs) and the development of sensing applications based on the fabricated fibers. Particularly, several types of MOFs including birefringent and photosensitive fibers will be introduced. To fabricate the special MOFs, the stack-and-draw technique is employed to introduce asymmetrical stress distribution in the fibers. The microstructure of MOFs includes conventional hexagonal assembles, large-air hole structures, as well as suspended microfibers. The birefringence of MOFs can reach up to 10−2 by designing the air hole structure properly. Fiber Bragg gratings as well as Sagnac interferometers are developed based on the fabricated special MOFs to conduct sensing measurement. Various sensing applications based on MOFs are introduced.",signatures:"Zhengyong Liu and Hwa-Yaw Tam",downloadPdfUrl:"/chapter/pdf-download/58873",previewPdfUrl:"/chapter/pdf-preview/58873",authors:[{id:"208721",title:"Dr.",name:"Zhengyong",surname:"Liu",slug:"zhengyong-liu",fullName:"Zhengyong Liu"},{id:"208963",title:"Prof.",name:"Hwa-Yaw",surname:"Tam",slug:"hwa-yaw-tam",fullName:"Hwa-Yaw Tam"}],corrections:null},{id:"56937",title:"Photonic Crystal Fiber–Based Interferometric Sensors",doi:"10.5772/intechopen.70713",slug:"photonic-crystal-fiber-based-interferometric-sensors",totalDownloads:1250,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Photonic crystal fibers (PCFs), also known as microstructured optical fibers, are a highlighted invention of optical fiber technology which have unveiled a new domain of manipulating light in engineered fiber waveguides with unparalleled flexibility and controllability. Since the report of the first fabricated PCF in 1996, research in PCFs has resulted in numerous explorations, development and commercialization of PCF-based technologies and applications. PCFs contain axially aligned air channels which provide a large degree of freedom in design to achieve a variety of peculiar properties; numerous PCF-based sensors have been proposed, developed and demonstrated for a broad range of sensing applications. In this chapter, we will review the field of research on design, development and experimental achievement of PCF-based interferometric sensors for physical and biomedical sensing applications.",signatures:"Dora Juan Juan Hu, Rebecca Yen-Ni Wong and Perry Ping Shum",downloadPdfUrl:"/chapter/pdf-download/56937",previewPdfUrl:"/chapter/pdf-preview/56937",authors:[{id:"37307",title:"Prof.",name:"Perry Ping",surname:"Shum",slug:"perry-ping-shum",fullName:"Perry Ping Shum"},{id:"207907",title:"Dr.",name:"Dora Juan Juan",surname:"Hu",slug:"dora-juan-juan-hu",fullName:"Dora Juan Juan Hu"},{id:"208428",title:"Dr.",name:"Rebecca Yen-Ni",surname:"Wong",slug:"rebecca-yen-ni-wong",fullName:"Rebecca Yen-Ni Wong"}],corrections:null},{id:"57057",title:"Dual-Core Transversally Chirped Microstructured Optical Fiber for Mode-Converter Device and Sensing Application",doi:"10.5772/intechopen.70989",slug:"dual-core-transversally-chirped-microstructured-optical-fiber-for-mode-converter-device-and-sensing-",totalDownloads:1215,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"We propose and demonstrate the concept of transversally chirped microstructured optical fiber and its application for the development of new platforms for sensing and telecommunications devices. First, the feasibility of the structure is demonstrated through two different techniques of manufacture. Based on the proposed structure, a novel mode-converter device is numerically studied. It is found that the mode conversion between LP01 and LP11 modes can be continuously tuned by temperature changes from 25 to 75°C. And that, the coupling efficiency in the wavelength range between 1.2 μm and 1.7 μm is always higher than 65%. Consequently, the proposed mode converter can operate in the E + S + C + L + U bands. Finally, a similar structure was used to design a new sensing architecture, which consisting of a dual-core transversally chirped microstructured optical fiber for refractive index sensing of fluids. We show that by introducing a chirp in the hole size, the microstructured optical fiber can be a structure with decoupled cores, forming a Mach–Zehnder interferometer in which the analyte directly modulates the device transmittance by its differential influence on the effective refractive index of each core mode. We show that by filling all fiber holes with analyte, the sensing structure achieves high sensitivity (transmittance changes of 302.8 per RIU at 1.42) and has the potential for use over a wide range of analyte refractive index.",signatures:"Erick Reyes Vera, Juan Úsuga Restrepo, Margarita Varon and Pedro\nTorres",downloadPdfUrl:"/chapter/pdf-download/57057",previewPdfUrl:"/chapter/pdf-preview/57057",authors:[{id:"207458",title:"Ph.D. Student",name:"Erick",surname:"Reyes Vera",slug:"erick-reyes-vera",fullName:"Erick Reyes Vera"},{id:"210119",title:"Dr.",name:"Gloria Margarita",surname:"Varon Duran",slug:"gloria-margarita-varon-duran",fullName:"Gloria Margarita Varon Duran"},{id:"210120",title:"BSc.",name:"Juan",surname:"Usuga Restrepo",slug:"juan-usuga-restrepo",fullName:"Juan Usuga Restrepo"},{id:"210121",title:"Dr.",name:"Pedro",surname:"Torres",slug:"pedro-torres",fullName:"Pedro Torres"}],corrections:null},{id:"58243",title:"Multi-Core Optical Fibers: Theory, Applications and Opportunities",doi:"10.5772/intechopen.72458",slug:"multi-core-optical-fibers-theory-applications-and-opportunities",totalDownloads:2508,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:1,abstract:"Multi-core fibers (MCFs) have sparked a new paradigm in optical communications, as they can significantly increase the Shannon capacity of optical networks based on single-core fibers. In addition, MCFs constitute a useful platform for testing different physical phenomena, such as quantum or relativistic effects, as well as to develop interesting applications in various fields, such as biological and medical imaging. Motivated by the potential applications of these new fibers, we will perform a detailed review of the MCF technology including a theoretical analysis of the main physical impairments and new dispersive effects of these fibers, and we will discuss their emerging applications and opportunities in different branches of science.",signatures:"Andrés Macho Ortiz and Roberto Llorente Sáez",downloadPdfUrl:"/chapter/pdf-download/58243",previewPdfUrl:"/chapter/pdf-preview/58243",authors:[{id:"16540",title:"Dr.",name:"Roberto",surname:"Llorente",slug:"roberto-llorente",fullName:"Roberto Llorente"},{id:"207661",title:"Ph.D. Student",name:"Andres",surname:"Macho",slug:"andres-macho",fullName:"Andres Macho"}],corrections:null},{id:"58582",title:"Fabrication of Polymer Optical Fiber Splitter Using Lapping Technique",doi:"10.5772/intechopen.71868",slug:"fabrication-of-polymer-optical-fiber-splitter-using-lapping-technique",totalDownloads:1091,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This work involves in designing and developing a POF-based directional coupler/splitter using lapping technique and geometrical blocks. Two fiber strands were first tapered at the middle and they were attached to the geometrical blocks and lapped together. Design parameters that are used to develop this coupler/splitter are core diameter, Dc, etching length, Le, bending radius, Rc, coupling length, Lc and pressure, Fc. All the parameters were taken into account during characterization and analysis of the designed coupler in order to find the most optimum prototype coupler/splitter. Characterizations are done by experimental set-up to test the efficiency, splitting ratio, coupling ratio, excess loss and insertion loss for all the couplers/splitters. Through the characterization process and analysis, the optimized coupler with high splitting ratio and low excess loss were identified. Throughout the experimental process, some of the fibers were improved and renewed in order to realize the design and development of the coupler using this technique. The device can also be utilized as an optical tap and the applications of the device are not only limited in in-house network but also in automotive applications. By using a platform, several splitting ratio can be obtained by integrating different core-cladding thickness and bending radius in order to get the desired splitting ratio and excess loss.",signatures:"Latifah S. Supian, Mohd Syuhaimi Ab-Rahman, Norhana Arsad,\nChew Sue Ping, Nani Fadzlina Naim, Nurdiani Zamhari and Syed\nMohd Fairuz Syed Mohd Dardin",downloadPdfUrl:"/chapter/pdf-download/58582",previewPdfUrl:"/chapter/pdf-preview/58582",authors:[{id:"77356",title:"Dr.",name:"L.S.",surname:"Supian",slug:"l.s.-supian",fullName:"L.S. Supian"},{id:"171520",title:"Prof.",name:"Dr. Mohd Syuhaimi",surname:"Ab-Rahman",slug:"dr.-mohd-syuhaimi-ab-rahman",fullName:"Dr. Mohd Syuhaimi Ab-Rahman"},{id:"208738",title:"Dr.",name:"Norhana",surname:"Arsad",slug:"norhana-arsad",fullName:"Norhana Arsad"},{id:"208740",title:"Ms.",name:"Chew",surname:"Sue Ping",slug:"chew-sue-ping",fullName:"Chew Sue Ping"},{id:"208741",title:"Dr.",name:"Nani Fadzlina",surname:"Naim",slug:"nani-fadzlina-naim",fullName:"Nani Fadzlina Naim"},{id:"208742",title:"Ms.",name:"Nurdiani",surname:"Zamhari",slug:"nurdiani-zamhari",fullName:"Nurdiani Zamhari"},{id:"208972",title:"Dr.",name:"Syed Mohd Fairuz",surname:"Syed Mohd Dardin",slug:"syed-mohd-fairuz-syed-mohd-dardin",fullName:"Syed Mohd Fairuz Syed Mohd Dardin"}],corrections:null},{id:"57475",title:"Plastic Optical Fibre Sensor System Design Using the Field Programmable Gate Array",doi:"10.5772/intechopen.71451",slug:"plastic-optical-fibre-sensor-system-design-using-the-field-programmable-gate-array",totalDownloads:1116,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Extrinsic optical fibre sensor (OFS) systems use a fibre optic cable as the medium for signal propagation between the sensor and the sensor electronics using light rather than electrical signals. A range of different optical fibre sensors have been developed and electronic hardware system designs interfacing the sensor with external electronic systems devised. In this chapter, the use of the field programmable gate array (FPGA) is considered to implement the circuit functions that are required within a portable optical fibre sensor system that uses a light emitting diode (LED) as the light source, a photodiode as the light receiver and the FPGA to implement the system control, digital signal processing (DSP) and communications operations. The capabilities of the FPGA will be investigated and a case study sensor design introduced and elaborated. The OFS system will be based on the FPGA and will provide wireless communications to an external supervisory system. The chapter will commence with an overview of OFS systems and the typical architecture of the system. Then the FPGA will be introduced and discussed as a hardware alternative to a software programmed processor that is currently widely used. A case study will then be presented with a discussion into design considerations.",signatures:"Yong Sheng Ong, Ian Grout, Elfed Lewis and Waleed Mohammed",downloadPdfUrl:"/chapter/pdf-download/57475",previewPdfUrl:"/chapter/pdf-preview/57475",authors:[{id:"55261",title:"Dr.",name:"Ian",surname:"Andrew Grout",slug:"ian-andrew-grout",fullName:"Ian Andrew Grout"},{id:"208861",title:"Mr.",name:"Yong",surname:"Sheng Ong",slug:"yong-sheng-ong",fullName:"Yong Sheng Ong"},{id:"208862",title:"Prof.",name:"Elfed",surname:"Lewis",slug:"elfed-lewis",fullName:"Elfed Lewis"},{id:"208864",title:"Dr.",name:"Waleed",surname:"Mohammed",slug:"waleed-mohammed",fullName:"Waleed Mohammed"}],corrections:null},{id:"57708",title:"Fiber Optical Tweezers for Applying and Measuring Forces in a 3D Solid Compartment",doi:"10.5772/intechopen.71757",slug:"fiber-optical-tweezers-for-applying-and-measuring-forces-in-a-3d-solid-compartment",totalDownloads:1119,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"We developed an inclined dual fiber optical tweezers (DFOTs) for simultaneous force application and measurements in a 3D hydrogel matrix. The inclined DFOTs provide a potential solution for cell mechanics study in a three-dimensional matrix.",signatures:"Chaoyang Ti, Minh-Tri Ho Thanh, Yao Shen, Qi Wen and Yuxiang\nLiu",downloadPdfUrl:"/chapter/pdf-download/57708",previewPdfUrl:"/chapter/pdf-preview/57708",authors:[{id:"208217",title:"Dr.",name:"Yuxiang",surname:"Liu",slug:"yuxiang-liu",fullName:"Yuxiang Liu"},{id:"208669",title:"Ph.D. Student",name:"Chaoyang",surname:"Ti",slug:"chaoyang-ti",fullName:"Chaoyang Ti"},{id:"209039",title:"Dr.",name:"Minh-Tri",surname:"Ho Thanh",slug:"minh-tri-ho-thanh",fullName:"Minh-Tri Ho Thanh"},{id:"209040",title:"MSc.",name:"Yao",surname:"Shen",slug:"yao-shen",fullName:"Yao Shen"},{id:"209041",title:"Prof.",name:"Qi",surname:"Wen",slug:"qi-wen",fullName:"Qi Wen"}],corrections:null},{id:"58649",title:"Nonlinearity-Tolerant Modulation Formats for Coherent Optical Communications",doi:"10.5772/intechopen.73031",slug:"nonlinearity-tolerant-modulation-formats-for-coherent-optical-communications",totalDownloads:1484,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Fiber nonlinearity is the main factor limiting the transmission distance of coherent optical communications. We overview several modulation formats intrinsically tolerant to fiber nonlinearity. We recently proposed family of 4D modulation formats based on 2-ary amplitude 8-ary phase-shift keying (2A8PSK), covering the spectral efficiency of 5, 6, and 7 bits/4D symbol, which will be explained in detail in this chapter. These coded modulation formats fill the gap of spectral efficiency between DP-QPSK and DP-16QAM, showing superb performance both in linear and nonlinear regimes. Since these modulation formats share the same constellation and use different parity bit expressions only, digital signal processing can accommodate those multiple modulation formats with minimum additional complexity. Nonlinear transmission simulations indicate that these modulation formats outperform the conventional formats at each spectral efficiency. We also review DSP algorithms and experimental results. Their application to time-domain hybrid modulation for 4–8 bits/4D symbol is also reviewed. Furthermore, an overview of an eight-dimensional 2A8PSK-based modulation format based on a Grassmann code is also given. All these results indicate that the 4D-2A8PSK family show great promise of excellent linear and nonlinear performances in the spectral efficiency between 3.5 and 8 bits/4D symbol.",signatures:"Keisuke Kojima, Toshiaki Koike-Akino, Tsuyoshi Yoshida, David S.\nMillar and Kieran Parsons",downloadPdfUrl:"/chapter/pdf-download/58649",previewPdfUrl:"/chapter/pdf-preview/58649",authors:[{id:"209138",title:"Dr.",name:"Keisuke",surname:"Kojima",slug:"keisuke-kojima",fullName:"Keisuke Kojima"},{id:"221226",title:"Dr.",name:"Toshiaki",surname:"Koike-Akino",slug:"toshiaki-koike-akino",fullName:"Toshiaki Koike-Akino"},{id:"221227",title:"Mr.",name:"Tsuyoshi",surname:"Yoshida",slug:"tsuyoshi-yoshida",fullName:"Tsuyoshi Yoshida"},{id:"221228",title:"Dr.",name:"David. S.",surname:"Millar",slug:"david.-s.-millar",fullName:"David. S. Millar"},{id:"221229",title:"Dr.",name:"Kieran",surname:"Parsons",slug:"kieran-parsons",fullName:"Kieran Parsons"}],corrections:null},{id:"58338",title:"Fiber Laser for Phase-Sensitive Optical Time-Domain Reflectometry",doi:"10.5772/intechopen.72553",slug:"fiber-laser-for-phase-sensitive-optical-time-domain-reflectometry",totalDownloads:944,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"We have designed a new fiber laser configuration with an injection-locked DFB laser applicable for phase-sensitive optical time-domain reflectometry. A low-loss fiber optical ring resonator (FORR) is used as a high finesse filter for the self-injection locking of the DFB (IL-DFB) laser. By varying the FORR fidelity, we have compared the DFB laser locking with FORR operating in the under-coupled, critically coupled, and over-coupled regimes. The critical coupling provides better frequency locking and superior narrowing of the laser linewidth. We have demonstrated that the locked DFB laser generates a single-frequency radiation with a linewidth less than 2.5 kHz if the FORR operates in the critically coupled regime. We have employed new IL-DFB laser configuration operating in the critical coupling regime for detection and localization of the perturbations in phase-sensitive OTDR system. The locked DFB laser with a narrow linewidth provides reliable long-distance monitoring of the perturbations measured through the moving differential processing algorithm. The IL-DFB laser delivers accurate localization of the vibrations with a frequency as low as ~50 Hz at a distance of 9270 m providing the same signal-to-noise ratio that is achievable with an expensive ultra-narrow linewidth OEwaves laser (OE4020–155000-PA-00).",signatures:"Vasily V. Spirin, Cesar A. López-Mercado, Patrice Mégret and Andrei\nA. Fotiadi",downloadPdfUrl:"/chapter/pdf-download/58338",previewPdfUrl:"/chapter/pdf-preview/58338",authors:[{id:"7794",title:"Dr.",name:"Vasily",surname:"Spirin",slug:"vasily-spirin",fullName:"Vasily Spirin"},{id:"107849",title:"Prof.",name:"Patrice",surname:"Mégret",slug:"patrice-megret",fullName:"Patrice Mégret"},{id:"176723",title:"Dr.",name:"Andrei",surname:"Fotiadi",slug:"andrei-fotiadi",fullName:"Andrei Fotiadi"},{id:"218248",title:"Dr.",name:"Cesar",surname:"López-Mercado",slug:"cesar-lopez-mercado",fullName:"Cesar López-Mercado"}],corrections:null},{id:"58815",title:"Optoelectronic Design of a Closed-Loop Depolarized IFOG with Sinusoidal Phase Modulation for Intermediate Grade Applications",doi:"10.5772/intechopen.72592",slug:"optoelectronic-design-of-a-closed-loop-depolarized-ifog-with-sinusoidal-phase-modulation-for-interme",totalDownloads:1476,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"A depolarized fiber optic gyroscope (DFOG) prototype with closed-loop configuration, sinusoidal-bias, and serrodyne-feedback electrooptic phase modulations was designed. A complete optoelectronic design is realized by using computational simulation tools (optical subsystem: Synopsys®-Optsim™ software and electronic subsystem: National Instruments®-MultiSim™ software). The design presented here includes both optical and electronic circuits, being the main innovation, is the use of an analogical integrator provided with reset and placed in the feedback of the electrooptic phase-modulation chain that produces a serrodyne-shaped voltage ramp signal for obtaining the interferometric signal phase cancellation. The performance obtained for this model (threshold sensitivity ≤0.052°/h; dynamic range = ± 78.19°/s) does reach the IFOG intermediate grade (tactical and industrial applications) and does demonstrate the suitability and reliability of simulation-based software tools for this kind of optoelectronic design.",signatures:"Ramón José Pérez Menéndez",downloadPdfUrl:"/chapter/pdf-download/58815",previewPdfUrl:"/chapter/pdf-preview/58815",authors:[{id:"208797",title:"Dr.",name:"Ramón José",surname:"Pérez Menéndez",slug:"ramon-jose-perez-menendez",fullName:"Ramón José Pérez Menéndez"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1505",title:"Scanning Electron Microscopy",subtitle:null,isOpenForSubmission:!1,hash:"3305b759b0efc22e8ed16e9048818817",slug:"scanning-electron-microscopy",bookSignature:"Viacheslav Kazmiruk",coverURL:"https://cdn.intechopen.com/books/images_new/1505.jpg",editedByType:"Edited by",editors:[{id:"100815",title:"Dr.",name:"Viacheslav",surname:"Kazmiruk",slug:"viacheslav-kazmiruk",fullName:"Viacheslav Kazmiruk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2397",title:"Advanced Aspects of Spectroscopy",subtitle:null,isOpenForSubmission:!1,hash:"bcc83fcd6b4bbfdaa677b37d94bdbdb6",slug:"advanced-aspects-of-spectroscopy",bookSignature:"Muhammad Akhyar Farrukh",coverURL:"https://cdn.intechopen.com/books/images_new/2397.jpg",editedByType:"Edited by",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3166",title:"Optoelectronics",subtitle:"Advanced Materials and Devices",isOpenForSubmission:!1,hash:"b7263978cf34e637a4b9592eb4975f3e",slug:"optoelectronics-advanced-materials-and-devices",bookSignature:"Sergei L. 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\r\n\tIn March 2022, another book on human migration seems important when the events or tragedies unfolding in Eastern Europe are considered. People have always migrated and have moved, but, specifically looking at the last three hundred years, involuntary migration is on the rise. Involuntary migration does not only affect Europe; Asia, Africa, and North as well as South America, have had their fair share of natural catastrophes, invasions, and wars.
\r\n\tThis book will intend to look at different migrant patterns, voluntary and involuntary migration, over the last three centuries. What influenced people to leave their home countries, family, and friends and settle somewhere else? The book may include histories of the 19th century, consider tragedies and movements activated by political events in the 20th century, and/or look at recent events of the 21st century. Push and pull factors are important points. While most of us may be influenced in a negative way by the current happenings in Eastern Europe, the Russian invasion and resulting tragedies also demonstrate some very positive human traits – the preparedness of Ukraine’s surrounding countries to help those in need and to provide a safe place for the present.
\r\n\tWhether one looks at voluntary or involuntary migration into any country, after a period of adjustment, migrants do play a positive role. The research found that migrants contribute to the economy (food, shelter, employment, tax) and enrich a country’s cultural norms. Prerequisites for successful settlements are that the host society adopts a tolerant approach and that the migrants recognize the law and the language of the host country. Nothing is ever easy or without controversy, but I am a migrant (German Australian), and life in Australia has been relatively harmonious. Issues that could be considered in the book are multicultural societies (do monocultural societies still exist?) and theories of acculturation versus integration (settlement processes).
\r\n\tTwo further issues are very important in relation to human migration. There is climate change, global warming, and the environment, which clearly affect people’s movement. Small island populations are very concerned about rising sea levels. 2021 has also seen floods costing human lives: Turkey (August 2021), Brazil (December 2021), Chile (January 2021), and South India (November 2021), to name but a few. In Australia (March 2022), farms and whole townships in New South Wales and Queensland have been flooded for the second time in five years, and plans to resettle these towns are considered. Official and social media provide ample coverage of the events, which leads me to the next issue. There is today’s very important role of the media, of the official and social media. We are constantly bombarded with images of human war tragedies and flood victims. People in industrialized, western countries must be the best-informed populace. How far do the images and up-to-date TV news influence us, make us change our behavior, and perhaps even consider us more generous than we have been?
\r\n\tClimate change and the media are relatively new to the human migration debate, but both issues play important parts, and some interesting discussions are appreciated.
\r\n\t
Serum estrogen levels are correlated with symptoms of aging in men, and estrogen may therefore play an important role in aging [1, 2]. Several previous studies have suggested that estrogen levels may also affect erectile function [3, 4, 5, 6]. Indeed, older and obese men have been found to have not only low androgen levels but also high estrogen levels. Since testosterone is metabolized to estradiol by aromatase, the particularly high aromatase levels in visceral adipose tissue may explain the elevated estradiol levels among obese men [7]. Visceral adipose tissue often accumulates among men with increasing age. Interestingly, high estrogen levels have been observed in older patients who present with a lack of sexual interest and erectile dysfunction (ED); therefore, these symptoms in the elderly are thought to involve a pathophysiological estrogen-testosterone imbalance [6, 8, 9, 10].
Accordingly, in this review, we discuss the effects of sex hormone imbalances on male erectile function.
There are many reports on erectile function and sexual hormones. Erectile function is controlled by complex mechanisms [11], including the vascular and nervous systems [12, 13, 14, 15, 16]. One of the most important materials is a nitric oxide (NO). After NO is releasing in the penis, corporal smooth muscle relaxes. However, when NO production is decreased, the erectile function weakened, resulting in ED. The relaxant system is also important for the erectile function. The relaxant system is controlled by both the endothelial and the nervous systems. When the upper stream of smooth muscle relaxant system is weakened, ED is caused; therefore, many studies have focused on smooth muscle relaxation. In contrast, corporal smooth muscle contraction is controlled by constrictors, such as noradrenaline in the flaccid state. However, if the contraction be upregulated in some situations, ED would be caused.
Interestingly, some studies have indicated that smooth muscle relaxation and contraction balance is disturbed by abnormal activation of contractile signaling pathway such as the adrenergic regulation. In some syndromes causing ED, such as diabetes mellitus or metabolic syndrome, the contraction is enhanced [17, 18, 19]. One of the important contractile signaling pathways is the RhoA/Rho-kinase signaling pathway. The enhancement is known to occur in aged individuals. The inhibition of RhoA/Rho-kinase signaling pathway by Y-27632 has been shown to improve ED in aged animal models [20, 21]. Interestingly, the contractility of smooth muscle in the corpus cavernosum is regulated by sexual hormones and may play a significant role in erectile function.
Testosterone deficiency and ED have been studied extensively [22, 23, 24, 25]. Testosterone deficiency causes ED using castrated animal models [26]. Furthermore, the erectile function is discussed by the endothelial NO synthase (eNOS) and neuronal NOS (nNOS) signalings. In some studies, testosterone administration to the castrated animals improved NOS expression in the penis and restored the erectile function [27]. Li et al. showed that testosterone deficiency decreases the upregulating reactive oxygen species production and it decreased eNOS activity (the phospho-eNOS/eNOS ratio) [28]. They also showed the reduction in eNOS activity induced cGMP levels decreased in the penis. Testosterone also alters phosphodiesterase type 5 (PDE-5) expression in the penis. Traish et al. showed that testosterone deficiency decreases PDE-5 activity using the rabbit model [29]. Additionally, Zhang et al. showed that PDE-5 expression was decreased by castration in the rat corpus cavernosum and that testosterone replacement therapy to the rats improved the expression [30]. These results indicate that testosterone is important for regulating PDE-5 expression. Traish et al. also suggested testosterone regulates not only NOS but also PDE-5 [31].
Testosterone also affects the smooth muscle of the corpus cavernosum. Reilly et al. reported that testosterone deficiency reduces the number of α-adrenergic-1 receptors in the castrated rats’ smooth fascia [32]. Moreover, testosterone modulates the adrenergic response of the corpus cavernosum vascular smooth muscle [33]. These results indicate that when testosterone levels decrease, smooth muscle contractility also decreases. On the other hand, Sopko et al. showed that the levels of RhoA and Rho-kinase proteins are increased in the castrated rats’ corpus cavernosum [34]. Their results indicated that testosterone deficiency increased smooth muscle contractility, leading to the decreasing erectile function and hypertension. Thus, although testosterone deficiency may increase contraction, additional research is required to more fully elucidate its impact on smooth muscle contraction.
Interestingly, testosterone also directly affects smooth muscle relaxation. Using isometric tension analysis, Yue et al. showed that the smooth muscle of rabbit coronary arteries and aortas are relaxed by testosterone [35]. Others have also reported that testosterone activates smooth muscle ATP-sensitive K+ channels and regulates the relax response of the smooth muscles [36]. These findings indicate that testosterone may regulate erectile function locally by acting on corpus cavernosum smooth muscle. These results indicate that testosterone may affect both genomic and nongenomic mechanisms of erectile function.
Testosterone also affects the structure of the penis. For example, castrated rats exhibit smooth muscle loss and fibrosis [37], and testosterone deficiency increases the volume of collagen in the internal pudendal arteries [38]. These effects of testosterone indicate that testosterone deficiency causes programmed trabecular smooth muscle cell death (apoptosis) [29]. Traish et al. also indicated that testosterone deficiency is related to the accumulation of fat-containing cells (fibroblasts or preadipocyte-like cells), particularly in the penis [39]. Interestingly, Wang et al. showed that testosterone deficiency decreases erectile function and increases collagen in the corporeal cavernosum by inhibiting autophagy and promoting apoptosis of the smooth muscle cells in rats’ penis [40]. Although their report had several limitations, they discussed the important role of testosterone in regulating the structural integrity of the corpus cavernosum and erectile function. This resulted from testosterone regulating the counterregulation of autophagy and apoptosis by modulating the interactions between BECN1 and Bcl-2 (key dual regulators of autophagy and apoptosis) [41, 42].
Estrogen, the female sex hormone, also affects erectile function. Interestingly, Tivesten et al. reported that that circulating free testosterone is positively associated with the ankle-brachial index (ABI) in a large population-based cohort of elderly males. They show that testosterone has a negative association with the degree of atherosclerotic disease in the lower extremities [43]. On the other hand, estrogen also has association with ABI negatively in the males, leading to higher estradiol levels associated with increased atherosclerosis. Besides, when lower extremity peripheral arterial disease (PAD) was defined as an ABI of less than 0.90, they showed that low serum testosterone and high serum estradiol are associated with lower extremity PAD. Moreover, both low testosterone levels and elevated estradiol levels affect erectile function and are associated with increased ED severity when present individually or concomitantly [44]. Low testosterone levels were thought to be the main effector; however, the presence of concomitantly elevated estradiol levels increased the severity of ED in patients with low testosterone levels. These reports indicated that female sex hormones also affect male health. Srilatha and Adaikan demonstrated that estradiol-testosterone imbalance is a risk factor for ED [8, 45, 46]. They showed that higher levels of estradiol were present in older patients experiencing with lack of sexual interest and ED, after adjustment for age [8]. Additionally, they concluded that the estradiol-testosterone hormonal balance may be a determinant of successful management outcomes for ED. Wu et al. also reported an association between sexual dysfunction and changes in estradiol and testosterone levels in Chinese men [47], and O’Connor et al. reported that estradiol was associated with sexual function-related distress; higher levels were related to greater distress in 2838 men, ages 40–79 years, who completed the European Male Aging Study-Sexual Function Questionnaire [48]. These reports specifically demonstrated the relationship between high estrogen milieu and male erectile function.
Serum estrogen levels are controlled by aromatase but can be altered under some conditions. Lamba et al. reported that antiretroviral therapy is associated with sexual dysfunction and increased serum estradiol levels in men [49]. Moreover, they found that total estradiol levels may be increased based on sex hormone-binding globulin (SHBG) levels. Drugs such as phenytoin are known to cause elevations in serum estradiol and SHBG [50]. Increased levels of SHBG, for example, due to induction of aromatase or SHBG synthetase, lead to a decrease in the free androgen index. Additionally, increased levels of SHBG and/or a low free androgen index have been associated with hypertension, osteoporosis, varicose veins, sexual dysfunction, and adverse serum lipids [51, 52, 53, 54, 55, 56]. All these side effects have been reported in association with antiretroviral therapy as well. SHBG, similar to other globulins, is upregulated in patients with acquired immunodeficiency syndrome and human immunodeficiency virus infection [57, 58]. Hassan et al. have also reported the association of overhydration with male sexual dysfunction and depression in hemodialysis patients [59]. They showed that overhydration in hemodialysis patients was associated with a higher prevalence of sexual dysfunction and depression, lower serum levels of total testosterone and dehydroepiandrosterone, and higher levels of serum estradiol. Intriguingly, Tivesten et al. reported that circulating estradiol is a predictor of the progression of carotid artery intima-media thickness in middle-aged men [60]. They also reported that elderly men with low serum testosterone and estradiol have increased risk of mortality and that patients with low testosterone and estradiol levels have the highest risk of mortality [61]. Serum estrogen levels can be altered by some drugs and sex hormones. Therefore, ED induced by high estrogen may be related to mortality.
Interestingly, estrogen administration decreases erectile function in animal models [62, 63]. Researchers administered estradiol orally to rats, resulting in high estradiol levels and low testosterone levels. Moreover, the intracavernous pressure (ICP) response to nerve stimulation was also impaired in all treated groups, and trichrome staining demonstrated the presence of cavernosal connective tissue hyperplasia in long-term study groups [62]. Oral administration of estradiol to rabbits resulted in high estradiol levels and low testosterone levels, similar to the effects in rats. Additionally, acetylcholine induced endothelium-mediated relaxation in normal animals, but this effect was significantly attenuated in treated groups, and NO-mediated nonadrenergic, noncholinergic neurotransmission was decreased in the treatment groups [63].
In our previous studies, subcutaneous administration (s.c.) of estradiol to rats resulted in high estradiol levels and low testosterone levels, thereby decreasing erectile function [64]. Moreover, we administered testosterone to rats with high estrogen-induced testosterone deficiency; however, erectile function did not improve. Interestingly, estrogen administration increases the contraction of smooth muscle in the corpus cavernosum, upregulating the RhoA/Rho-kinase signaling pathway, which is involved in ED [18]. Vignozzi et al. demonstrated that high-fat diet-induced ED is associated with high estradiol levels, rather than low testosterone levels [65].
We also investigated the influence of estradiol-testosterone imbalance on erectile function in rats (Figures 1–6; Table 1). Male Wistar ST rats (11 weeks old, Japan SLC Inc., Hamamatsu, Japan) were separated into five groups. In the low testosterone (Low-T) group (n = 11), rats were injected with goserelin (LH-RH agonist, 0.9 mg/kg, s.c.). In the low testosterone and high estrogen (Low-T/High-E) group (n = 11), rats were injected with goserelin and estradiol (3 μg/kg/day, s.c.) daily from weeks 2 to 4. In the high estrogen (High-E) group (n = 11), rats were injected with estradiol daily from weeks 2 to 4. In the high estrogen and testosterone (High-E/High-T) group (n = 11), rats were injected with estradiol and testosterone (3 mg/kg/day, s.c.) daily from weeks 2 to 4. In the control group (n = 11), rats were not injected with any hormone. Table 1 shows the sex hormone concentrations in rats. Goserelin injection significantly decreased serum bioavailable testosterone (control: 1.20 ± 0.13 ng/mL, Low-T: 0.55 ± 0.04 ng/mL,
Experimental design. In the control group, rats were injected with vehicle for 2 weeks. In the Low-T and High-E groups, rats were injected with goserelin acetate (LH-RH agonist, 0.9 mg/kg subcutaneously) at day 0. In the estrogen-treated (High-E) group, rats were injected with estradiol (3 mg/kg/day subcutaneously) for 2 weeks. In the estrogen- and testosterone-treated (High-E/High-T) group, rats were injected with estradiol (3 mg/kg/day subcutaneously) and testosterone (3 mg/kg/day subcutaneously) for 2 weeks. At the end of the period, rats were underwent erectile function testing in vivo or in vitro.
Measurement of intracavernous pressure (ICP). Maximum ICP changes during electrical stimulation of the cavernous nerve in the control, Low-T, High-E, High-E/Low-T, and High-E/High-T groups. Data represent the means ± standard errors of the means (n = 6 per group). **
The contraction curves induced by noradrenaline (NA) in rat corpus cavernosum strips. The contractile tone induced by 80 mM KCl was taken as 100%. Data reported in all graphs represent the means ± standard errors of the means (n = 5 per group). *
The relaxation curve induced by sodium nitroprusside (SNP) in rat corpus cavernosum strips. The strips were precontracted using 10−5 M NA. Data reported in all graphs represent the means ± standard errors of the means (n = 5 per group). *
The relaxation curves induced by Rho-kinase inhibitor Y-27632 in rat corpus cavernosum strips. The strips were precontracted using 10−5 M NA. Data reported in all graphs represent the means ± standard errors of the means (n = 5 per group). *
The rat penis sections of Masson’s trichrome staining. (A) Representative specimens of corpus cavernosum of each group rats. (B) Histological evaluation of the tissues. The area ratios of the collagen fibers, smooth muscle (SM), and others were calculated using computerized image analysis. Data reported in all graphs represent the means ± standard errors of the means (n = 3 per group).
Bio-T (ng/mL) | Estrogen (pg/mL) | |
---|---|---|
Control | 1.20 ± 0.13 | 102.5 ± 8.7 |
Low-T | 0.55 ± 0.04** | 51.2 ± 4.2 |
High-E | 0.90 ± 0.12 | 332.3 ± 17.4** |
High-E/Low-T | 0.73 ± 0.06* | 275.4 ± 34.4** |
High-E/High-T | 2.58 ± 0.31** | 401.5 ± 51.6** |
Serum levels of estrogen and bioavailable testosterone (bio-T) in rats.
Data are expressed as means ± standard errors of the means. *
Figure 2 shows the erectile response to electrical field stimulation of the cavernous nerve in the different experimental groups. Analysis of the ICP/MAP ratio revealed that the ratios in the Low-T (0.52 ± 0.03), Low-T/High-E (0.46 ± 0.03), High-E (0.44 ± 0.03), and High-E/High-T (0.44 ± 0.02) groups, which represented all treated rats, were significantly lower than in the control group (0.70 ± 0.04,
Figure 3 shows the contractile response of rat corpora cavernosa strips to increasing concentrations of noradrenaline (NA). Increasing concentrations of NA were found to contract rat corpora cavernosa strips in all groups. In particular, 10 μM NA resulted in statistically significant differences in the in vitro penile contractile response among the experimental groups (control: 154.5 ± 14.1%, Low-T: 169.8 ± 14.8%, Low-T/High-E: 200.2 ± 21.1%, High-E: 198.9 ± 15.3%, High-E/High-T: 249.7 ± 13.5%). Although the contractile response did not differ between the control group and the Low-T group (
Figures 4 and 5 show the relaxant response of NA-precontracted rat corpora cavernosa strips to increasing concentrations of sodium nitroprusside (SNP) and Y-27632. In all groups, increasing concentrations of the NO donor SNP relaxed rat corpora cavernosa strips (control: Emax = 16.8 ± 10.3%, Low-T: Emax = 59.7 ± 7.6%, Low-T/High-E: Emax = 53.4 ± 5.0%, High-E: Emax = 55.2 ± 6.8%, High-E/High-T: Emax = 61.1 ± 1.5%). In the treated groups, the sensitivities to SNP were significantly lower than in the control group (
Figure 6 shows the histological analysis of the rats’ corpora cavernosa. The area ratio of the cavernous smooth muscle was analyzed (control: 10.5 ± 1.4%, Low-T: 7.4 ± 1.1%, Low-T/High-E: 13.2 ± 0.4%, High-E: 11.6 ± 0.1%, High-E/High-T: 19.4 ± 1.1%). Similarly, the area ratio of the collagen fiber was analyzed (control: 58.4 ± 2.5%, Low-T: 63.2 ± 3.0%, Low-T/High-E: 66.5 ± 2.3%, High-E: 58.8 ± 2.2%, High-E/High-T: 58.7 ± 1.4%). No statistically significant differences between the experimental groups were observed in the overall area ratios of smooth muscle, collagen fiber, and other parameters according to χ2 tests for independence (
Several reports have suggested an association between ERs and ED. Schultheiss et al. have shown the ER distribution in the corpus cavernosum penis of adult humans [66]. Additionally, Dietrich et al. have demonstrated that the corpus cavernosum and corpus spongiosum smooth muscles were immunoreactive for the androgen receptor (AR), ER-α, and ER-β and that endothelial cells were negative for AR, sporadically positive for ER-α, and positive for ER-β [67]. Jesmin et al. have demonstrated that ER-α was predominantly localized in the sensory corpuscle of the glans penis [68]. On the bother hands, they also reported that the ER-β was localized around the neurovascular bundle, artery, and nerve [68]. Spyridopoulos et al. have shown that the potential antiapoptotic effects of estrogen were impaired by reduced ER-β expression, and loss of antiapoptotic genes in the rat corpus cavernosum was associated with the pathogenesis of ED [69]. These reports indicate that the ER exists in the corpus cavernosum and has various functions. Moreover, the ER has been reported to be altered under some conditions. Shirai et al. have demonstrated that vascular endothelial growth factor treatment restores erectile function through stimulation of the insulin-like growth factor system and
Some endocrine-disrupting chemicals have physiological effects similar to those of estrogen. Bisphenol A (BPA) is a widely used endocrine-disrupting chemical that is thought to have adverse health effects [80]. BPA has been widely produced and used as a common ingredient in the manufacture of plastics. Humans are mainly exposed to BPA through ingestion of foods containing BPA, and increasing evidence supports its association with impaired male reproductive function [81]. Manfo et al. reported that BPA also decreases erectile function [82], and Li et al. showed that BPA-exposed workers had significantly increased risk of ED (odds ratio = 4.5, 95% confidence interval: 2.1–9.8) [83, 84]. Moon et al. were the first to report the influence of BPA on erectile function using animal model [85]. They observed thickening of tunica albuginea, subtunical deposition of fat, and decreased sinusoidal space with subsequent increases in trabecular smooth muscle content by histological analysis in BPA-treated animals and demonstrated endothelial dysfunction in BPA-treated rabbits. Kovanecz et al. also reported that BPA decreases nNOS and vascular endothelial growth factor expression in rats [86, 87]. In these reports, BPA-induced ED was similar to high estrogen-induced ED. Thus, the relationship between endocrine-disrupting chemicals and ED should be carefully considered.
PDE-5 inhibitors are the first choice for patients with ED. Recently, some interesting papers on PDE-5 inhibitors and estrogen have been published. Greco et al. reported a reduction in estrogen levels in patients with ED after chronic exposure to tadalafil, a PDE-5 inhibitor, and a concomitant increase in the testosterone-estrogen ratio [88]. They also showed that increased testosterone-estrogen ratios were not related to increases in testosterone serum levels, but rather to the possible effects of tadalafil on aromatase activity. Aversa et al. also demonstrated that daily tadalafil decreases serum estradiol levels [9]. In contrast, Spitzer et al. have reported that the PDE-5 inhibitor sildenafil increased estradiol levels in 40 men (ages 40–70 years) with ED, despite increasing testosterone levels [89]. Additionally, several reports have demonstrated that PDE-5 inhibitors increase testosterone levels [90, 91, 92, 93, 94, 95, 96]. When testosterone is low, estradiol levels may also be low because testosterone is metabolized to estradiol by aromatase. PDE-5 inhibitors can increase not only testosterone but also estradiol in patients with low testosterone levels. Therefore, estrogen levels should be carefully monitored in patients receiving PDE-5 inhibitors.
The sex hormone milieu affects erectile function, and sex hormone imbalances, particularly low testosterone levels combined with high estrogen levels, cause ED. Interestingly, estradiol has protective effects on female health, but harmful effects on male erectile function. Overall, these results provide insights into the possible treatments of endocrine-related ED. Future research should confirm these findings in more specific experiments using molecular tools.
The authors declare no conflicts of interest.
Globally, the building sector is accountable for 30% of the total final energy consumption and without action, the energy demand in this sector could increase by another 30% by 2060 [1]. Again, buildings represent 28% of global energy-related CO2 emissions worldwide [2]. This sector’s energy consumption is related to human programmes involving the use of equipment, lighting and other electrical appliances [3]. The household/residential sector, which forms part of the total building stocks, has been identified as one of the target groups for energy efficiency programmes [4, 5] also underscored that households can adopt and implement energy efficiency measures to reduce energy consumption significantly.
The residential sector in Ghana accounts for 47% of the total final energy consumption [6], compared to other countries such as the United States (25%), United Kingdom (30%), Japan (26%), Saudi Arabia (50%), China (15.8%) and Malaysia (15%) [5, 7, 8, 9]. Electrical appliances such as refrigerators, freezers and room air conditioners (RACs), which are energy-intensive, are among the most common Ghanaian household appliances. Whilst refrigerators and freezers consume between 25–30% of the total residential energy use, air conditioners account for 6.5% of residential energy use in Ghana [10]. Whilst [11] indicated that most of the markets in sub-Saharan Africa (SSA) countries are inundated with “used electrical appliances” [12], assert that this phenomenon was a result of the proliferation of used or “second-hand” goods from Europe and elsewhere. For instance, it has been estimated that there were over two (2) million used and inefficient refrigerating appliances in Ghana in 2012 that were laden with hydrofluorocarbons (HFCs) [13]. This large number was primarily due to the introduction of standards and labelling in developed countries and the era of energy efficiency programmes in Europe in the early 1970s saw many of these countries disposing of their old and energy inefficient appliances into SSA [14]. The share of the used electrical appliance market in Ghana at the time was about 80%, thereby promoting climate injustice [14]. These used and inefficient refrigerating appliances consume, on average, 1200 kWh per unit per year compared to 250 kWh and 400 kWh per year in Europe and the US respectively [15].
Minimum energy performance standards (MEPS) and the introduction of more efficient appliances through energy efficiency standards and labelling (EES&L) programmes have been identified as potential means of reducing the energy consumption of these inefficient appliances. It has been noted that improving energy efficiency is the best way to simultaneously meet sustainable development goals (SDGs) 7 and 13 in the energy sector [16]. This approach, when used judiciously, frees resources for other projects, helps economies to grow and reduces environmental impacts such as greenhouse gas (GHG) emissions. MEPS programmes have also proven to be effective in stimulating the development of cost-effective, energy-efficient technologies and are said to be the cornerstone of most national energy and climate change mitigation programmes [17].
Ghana’s move to improve its energy efficiency is part of a larger energy sector reform programme designed to support the country’s long-term economic developmental agenda. In 2002, Ghana, therefore, identified the benefits of MEPS such as EES&L programmes for equipment and other electrical appliances such as deep freezers, RACs, refrigerators, industrial motors and lighting systems [18]. These standards and labelling programmes serve as benchmarks and catalysts in meeting the MEPS objectives.
According to [19], energy efficiency legislations and policies have continued to increase globally through energy efficiency research and developmental programmes [20]. However, several barriers attributable to the low adoption and implementation of MEPS in SSA have to be overcome. These barriers, according to [21, 22], include financial constraints, techno-economic, political-institutional barriers, market barriers, lack of incentives and lack of information (knowledge). As a result of market failures in SSA, [23] suggested in his paper, “The market for lemons: Quality and uncertainty in the market mechanism”, that in markets where consumers do not have reliable and adequate information in respect of the quality of the products, it leads to the proliferation of cheaper and low-quality products. The effect of this failure is that more efficient products or appliances are pushed out of the market space.
Notwithstanding these continental constraints, Ghana was able to overcome these barriers through stakeholders’ consultative engagements using the
Energy efficiency standards and labelling (non-ducted air conditioners and self-ballasted fluorescent lamps) regulations 2005 (L. I 1815);
Energy efficiency (prohibition of manufacture, sale or importation of incandescent filament lamp, used refrigerator, used refrigerator-freezer, used freezer and used air-conditioner) regulations 2008 (L. I 1932);
Energy efficiency standards and labelling (household refrigerating appliances) regulations 2009 (L. I 1958); and
Energy commission (efficiency standards and labelling (light emitting diode and self-ballasted fluorescent lamps) regulations 2017 (L. I 2353).
These standards and labelling initiatives provide a mandatory labelling regime in Ghana, where energy guide labels have to be affixed conspicuously on these appliances to indicate the minimum energy performance levels of these appliances. The indicators on these energy guide labels include annual energy consumption, type of refrigerant, climate class, star rating, manufacturer, model number, fresh and frozen volumes. This mandatory labelling regime is intended to promote energy efficiency, transform the appliances market, reduce energy demand in households and reduce Ghana’s energy-related CO2 and ozone-depleting substances (ODS) emissions. This paper reviews the impact of the first three regulations and other energy efficiency projects between 2007 and 2020.
To commence the enforcement of these regulations, the national refrigerator turn-in and rebate scheme was launched by the Government of Ghana, on the advice of the Ghana Energy Commission in July, 2012. The objective was to recover about fifty thousand (50,000) inefficient refrigerating appliances from homes and encourage individuals to use more energy-efficient ones. So, in 2013, the Ghana Energy Commission commenced the full implementation of these regulations at the ports of entry. It is therefore imperative to review and establish the impact of these regulations between 2007 and 2020.
The rest of the paper is organized as follows: the next section following the introduction looks at the methodology being employed. The concept of energy efficiency is examined in Section 3. Section 4 provides the Global and National overviews of MEPS implementations. Testing and inspection protocols for refrigerating, lighting and air-conditioning equipment in Ghana are considered in Section 5. Section 6 offers the discussion of the results of some of the real impacts due to MEPS whilst Section 7 concludes the paper.
This section explains the methodology adopted for this work.
The content of this desktop review is based on energy efficiency appliance import data, policy documents and market transformation data from the Ghana Energy Commission, Energy Foundation, Council for Scientific and Industrial Research—Institute of Industrial Research (CSIR-IIR), Ghana Revenue Authority (GRA-Custom Division) and Ghana Statistical Service (GSS). Other sources of information include the International Energy Agency (IEA) as well as other related web searches. Besides, global and SSA energy efficiency documents were also reviewed by examining secondary data from standards, regulations, protocols, market report series and other available statistical data.
The basic assumption for computing electricity savings is that without MEPS regulation and its accompanying awareness programmes. Eqs. (1)–(4) were used to estimate the annual energy saving per appliance, total energy savings for all the appliances and CO2 emissions reductions between 2007 and 2020 as a result of MEPS implementation. Therefore, the annual electricity saving,
where
The total annual electricity saving,
The total cost savings from MEPS implementation are computed in terms of the electricity savings from operating a more efficient appliance. Thus, the annual electricity savings computed using Eq. (2) is used to estimate the total cost savings by multiplying the computed electricity savings with the electricity tariff as shown in Eq. (3):
where
The annual carbon emission reduction,
where
Several definitions for energy efficiency have emerged over the years. Energy efficiency may be considered as investing in more energy-efficient technologies or appliances which results in more energy savings. [24] defines energy efficiency as “using energy cautiously and economically to sustain everyday life, live comfortably and support wellbeing”. According to [25], energy efficiency is achieving the same service and performance while using technology with less energy use and therefore enhancing the security of the energy supply. For [26], energy efficiency is an effective tool for reducing electricity or energy consumption which limits greenhouse gas (GHG) emission and thereby reducing global warming.
This section reviews the Global and the Ghanaian perspectives of MEPS and EES&L programmes.
Both minimum energy performance standards (MEPS) and energy efficiency standards and labelling (EES&L) for appliances are the two known key mitigation strategies for electricity conservation worldwide [27]. MEPS is a technique of eliminating inefficient performing appliances through the prescription of minimum efficiency (or maximum energy consumption) that manufacturers must achieve [28]. The benefits of MEPS, according to [29, 30] include the following:
It allows manufacturers and suppliers to increase appliance efficiency since less-efficient appliances will no longer be tolerated for sale in the regulated market;
It encourages manufacturers to explore innovative and efficient technologies to gain a competitive edge;
It provides market consistency and certainty, thus creating economies of scale;
Consumers enjoy electricity cost savings over the lifetime of the appliance as these appliances on the market now consume less energy to operate; and
Appliance purchase prices are largely falling in real terms in many countries with MEPS regulations due to competition, economies of scale and marketplace innovations.
The main objectives of the EES&L regime are to [31];
Prevent the influx of substandard appliances on the market;
Provide the consumer an appliance the needed information to make an informed choice;
Provide information regarding the running cost of the appliance; and
Fulfil environmental treaty commitments such as the Paris Agreement, Kyoto Accord, Kigali Amendment, Montreal Protocol, Rotterdam Convention and Basel Convention.
EES&L programmes, introduced in the 1970s, are now being implemented in over eighty (80) countries including Ghana. The programmes cover more than fifty (50) types of appliances and equipment [32]. Testing protocols are used to determine appliance performance relating to energy efficiency. These protocols are periodically revised to ensure they keep up with trends and advances in technology.
Over the past decades, Ghana has made significant progress in its energy energy efficiency programmes [33]. These programmes put Ghana on the world map as a pioneer in SSA as a result of extensive collaborations of stakeholders and institutions such as the Ghana Energy Commission, Ministry of Energy, Ghana Standards Authority, Ghana Energy Foundation and CLASP [14]. Ghana experienced widespread power shortages due to series of droughts spanning from the 1980s to the 1990s. Energy efficiency programmes were identified to solve these power shortages as it delivers benefits faster than building new generating power plants [14]. The Government of Ghana, therefore, decided to support energy efficiency standards, policies and programmes. Consequently, the Ghana Electrical Appliance Labelling and Standards Programme (GEALSP) was launched to help transform the country’s appliance market. An initial assessment to determine the energy savings potential was then carried out from energy efficiency projects [10].
A comprehensive national household survey on demand-side management (DSM) was then conducted by the Ghana Energy Commission between 2003 and 2006. The results from the survey revealed that residential energy consumption, for example, was 50% of the total national energy use and refrigerating appliances accounted for nearly 59% of the residential use [15]. These used refrigerating appliances consume on average 1200 kWh per annum compared to 250 kWh and 400 kWh per annum in Europe and the US respectively [15] as illustrated in Figure 1 for comparative energy use basis.
Refrigerator Electricity use for Ghana, Europe and US in 2007 [
Energy efficiency programmes for household appliances was crucial and therefore needed to be adopted and implemented without further delay to bring Ghana’s consumption down (proposed standard—the green line in Figure 1). According to [33], energy efficiency is considered a “
No | Types of barriers | Measures |
---|---|---|
1. | Financial | Implementation of tax incentives and national programmes. For instance, between 2003 and 2016, import duties and taxes were removed from the importation and sale of compact fluorescent lamps (CFLs). |
2. | Market | Import duties and value-added tax (VAT) on compact fluorescent lamps (CFLs) were removed by government in April 2003, thus making them available and affordable to consumers. |
3. | Lack of information (knowledge) | Organization of national energy efficiency campaigns throughout the country using both print and electronic media. Also, leaflets, brochures and flyers were printed and distributed, including town hall meetings where relevant stakeholders were engaged. |
4. | Institutional | Holding stakeholders’ consultations and institutional reforms. For instance, Public Utility Regulatory Commission (PURC) is mandated to set electricity tariffs independent of governmental influence and to reward efficient users and punish inefficient users of electricity. Also, the Ghana Energy Commission came in with the labelling programme in 2005 to help in transforming the appliance market. |
5. | Technical | Technical cooperation with developmental partners was encouraged to offer training to Ghanaians. For instance, between 2012 and 2013, over 600 technicians were trained to carry out installation, repairs and maintenance of the new and efficient refrigerating appliances under the Ghana Energy Foundation and UNDP project to transform the appliance market. |
6. | Political | Independent regulatory bodies were created to deal with the energy crisis. For instance, the Ghana Energy Commission and Public Utility Regulatory Commission were mandated to carry out technical and economic regulations of the power sector respectively. The Ghana Grid Company was also responsible for the national network, separated from the distribution operator. All these programmes were moved from the Ministry of Energy to prevent any political interference. |
Types of energy efficiency barriers and measures to overcome them.
Four (4) Legislative Instruments (L.Is) were subsequently enacted by the Ghanaian Parliament in collaboration with the Ghana Energy Commission and Ghana Standards Authority. The first, energy efficiency regulations for non-ducted room air conditioners (RACs) and compact fluorescent lights (L.I. 1815) was developed in 2005 [34], which mandates that all RACs imported into Ghana must meet the minimum energy efficiency ratio (EER) of 2.8 W of cooling per watt of power input, equivalent to a 1-star rating. The second energy efficiency regulations (L.I. 1932) was also enacted in 2008 to help prevent the importation or sale of used inefficient refrigerating and air conditioning appliances in Ghana. To ensure that only energy efficient refrigerating appliances are imported and sold in Ghana, the energy efficiency standards and labelling regulation for household refrigerating appliances (L.I. 1958) was enacted in 2009. Finally, in 2017, the energy efficiency standards and labelling for light-emitting diode and self-ballasted fluorescent regulations (L.I. 2353) was enacted. The purpose of the fourth regulation is to enforce the standards for minimum energy efficiency for self-ballasted fluorescent lamps and light-emitting diode lamps imported or manufactured in Ghana.
Details of these four regulations and standard protocols for determining the energy efficiency star ratings for (non-ducted air-conditioners, household refrigerating appliances and lamps and CFLs), categories of household refrigerators and initial luminous efficacy of the lamps are available and can be assessed under Legislative Instruments (list of L.I’s for energy efficiency) at [35].
In conclusion, Ghana has developed and implemented four (4) main end-use policies, regulations and standards to promote demand-side management (DSM). Seventeen (17) other regulations are currently being developed for other electrical appliances such television (TV) sets, electric motors, washing machines, blenders, etc. Table 2 lists the four (4) regulations, its scope and targets, the year they were enacted by the Ghanaian Parliament and their implementation dates.
L.I. | Regulation | Scope & targets | Year passed | Year implemented |
---|---|---|---|---|
1815 | Energy efficiency standards and labelling (non-ducted air conditioners and self-ballasted fluorescent lamps) regulations. | Gives legal backing to the use of energy-efficient non-ducted air conditioners and fluorescent lamps. | 2005 | 2014 |
1932 | Energy efficiency (prohibition of manufacture, sale or importation of incandescent filament lamp, used refrigerator, used refrigerator-freezer, used freezer and used air-conditioner) regulations. | Places total ban on the importation and sale of incandescent filament lamp, used refrigerator, used refrigerator-freezer, used freezer and used air conditioners effective January 2012. | 2008 | 2013 |
1958 | Energy efficiency standards and labelling (household refrigerating appliances) regulations. | Provides for the enforcement of minimum energy efficiency and labelling for household refrigerating appliances. | 2009 | 2013 |
2353 | Energy commission (efficiency standards and labelling (light emitting diode and self-ballasted fluorescent lamps) regulations. | Provides for the enforcement of minimum energy efficiency and labelling for light emitting diode and self-ballasted fluorescent lamps. | 2017 | 2020 |
Main end-use policies and regulations.
To achieve the full potential of the MEPS programmes, Ghana adopted rigorous testing, approval and inspection procedures for importing these regulated appliances into the country. Currently, Ghana does not manufacture these appliances, so testing is done by third-party accredited laboratories such as Vkan Certification & Testing Co., Ltd. (CVC), Intertek, TUV-Rhineland, DEKRA Product Testing & Certification, General Society of Surveillance (SGS) and Bureau Veritis (BVAC). These testing facilities are recommended and designated by the Ghana Standards Authority and Ghana Energy Commission. A performance test report, which details the performance of the appliance in terms of energy consumption, approved refrigerant, climate class, star rating, etc. from these facilities, is then submitted to the Ghana Energy Commission by the importer concerning a particular model, for evaluation. Certificate of approval (COA), containing parameters of the said model, is issued to the importer for model(s) that meet the MEPS requirements as laid down in the energy efficiency guidelines [31].
The testing, approval and inspection procedures of a model are summarized in Figures 2 and 3.
Testing and approval processes for model(s) to be imported into Ghana.
Physical inspection procedures of a model at the ports of entry.
Having reviewed all the available documents, regulations, standards, procedures and processes, the next section provides some of the real impacts resulting from MEPS implementation in Ghana since 2007.
This section discusses the impact of the major energy efficiency programmes resulting from MEPS implementation in Ghana based on Eqs. (1)–(4) between 2007 and 2020.
In 2007, Ghana implemented an efficient lighting project (CFL exchange programme) regarding its policy directions in the area of energy efficiency. On the advice of the Ghana Energy Commission, the Government procured and distributed over six (6) million compact fluorescent lamps (CFLs) to replace the estimated six million incandescent lamps at no cost to the beneficiaries [36]. As a result of this project, incandescent lamp usage in households has reduced from 58–3% while CFLs penetration increased from 20% in 2007 to 79% in 2009 [36]. The country’s peak electricity demand was accordingly reduced by 124 MW and peak electricity consumption by 72.8 GWh per year due to this policy implementation. This resulted in an energy cost saving of about US$ 39.5 million per year and carbon dioxide (CO2) savings estimated at 105,000 tonnes per year [36]. Consequently, there was a delay in the generation expansion of thermal energy investment of US$ 105 million. At US$ 120/bbl, energy cost saving would amount to US$ 39.5 million per year [37]. The project received a Global Energy Efficiency Award in 2010 organized by the Energy Efficiency Global Forum in Brussels, Belgium (12–14 April 2011) [36].
Reports available at the Ghana Energy Commission indicated that the Government of Ghana, in September 2012, through the Ghana Energy Commission, launched the national refrigerator turn-in and rebate scheme with the support of the United Nation Development Programme (UNDP), Global Environment Facility (GEF) and Multilateral Fund of the Montreal Protocol (MFMP). The scheme, which encouraged consumers to exchange their old refrigerators for new and efficient ones, available at a discounted price, was to recover about 50,000 inefficient refrigerating appliances from homes and promote the use of more energy-efficient ones and transform the refrigerating appliances market in the country. By mid-June, 2016, a total of 10,472 units of old energy-inefficient appliances have been replaced across the country with new energy-efficient ones [38]. Customers who participated in the project had their consumption reduced from 1200 kWh per year to 385 kWh per year, resulting in a saving of about 400 GWh of electricity, 1.1 million tonnes of carbon dioxide (CO2) and about 1500 kg of Chlorofluorocarbon (CFC) recovered [38]. This translated into a household income saving of about US$ 140 per year [38].
The enforcement of L.I. 1932 at Ghana’s ports of entry by the Ghana Energy Commission prohibited the importation of an estimated number of 4,854,864 units of used refrigerating appliances between 2013 and 2020. A total of 5825.84 GWh of electricity would have been consumed with over 2.33 million tonnes of CO2 released into the atmosphere if the ban was not enforced. However, data available at the Ghana Energy Commission shows that a total of 46,666 used refrigerators and 11,003 used RACs were imported through illegal means by some recalcitrant importers. They were subsequently confiscated by the Ghana Energy Commission inspectors positioned at the ports and evacuated for e-disposal [39]. Figure 4 shows the yearly trend in the importation of used refrigerators, particularly the downward trend between 2013 and 2020 during MEPS implementation.
Yearly imported used refrigerating appliances to Ghana from 2005 to 2020.
The average annual energy consumptions of a used refrigerator and used RAC are 1200 kWh per year and 4000 kWh per year respectively [39]. The rigorous enforcement of L.I. 1932 since 2013, yielded a total of 100 GWh of electricity and 40,000 tonnes of CO2 savings for those confiscated used appliances based on Eqs. (2) and (3).
Enforcing L.I. 1958 resulted in the importation of 2,378,432 new and efficient refrigerating appliances into the country between 2013 and 2020, thus preventing the importation of used and inefficient ones [39]. Data analysis indicated that 92% of all refrigerating appliances imported between 2013 and 2020 were new and efficient in accordance with L.I. 1958. About 74.8% of these appliances were 2- to 5-star rated with 87.2% of all imports laden with R600a refrigerant (hydrocarbon) [39], which has both low global warming potential (GWP) and low ozone-depleting potential (ODP) and therefore more energy-efficient [40]. The remaining 8%, which were used refrigerators were confiscated. The rise in the importation and sale of new refrigerating appliances is primarily due to strict regulations, procedures and controls implemented at the ports of entry, regular market surveillance and stringent compliance monitoring. These measures help to ensure that only appliances that meet MEPS are permitted into the Ghanaian market. Figure 5 shows how the refrigerating appliance market in Ghana has evolved/transformed over the years (2005–2020) from being a completely used and inefficient refrigerator market (88.9% inefficient in 2005) to new and efficient ones (99.1% efficient in 2020) as a result of MEPS implementation.
Evidence of transformed market through MEPS from 2005 to 2020.
The average annual energy consumption of these new and efficient appliances has dropped drastically due to MEPS implementation compared with the used refrigerators. Consumption values reduced from about 1400 kWh per unit per year to 340 kWh per unit per year [39]. Figure 6 shows the trend in the average annual energy consumption patterns of refrigerating appliances over the years especially that during the implementation period.
Average annual energy consumption patterns for new fridges.
Assuming that 90% of the new refrigerating appliances were sold between 2013 and 2020. Figure 7 presents the analysis of the total electricity and CO2 emission savings based on Eqs. (1)–(3). From the analysis, a total of 5845 GWh electricity has been saved with a corresponding 2.56 million tonnes of CO2 emission savings resulting from MEPS due to L.I. 1958 enforcement. This is equivalent to more than 3.4% of the total
Analysis of total electricity and CO2 emission savings for refrigerating appliances.
A total of 904,923 new RACs were imported and inspected at the Port of Tema since 2014 [39]. About 54.6% of the RACs on the Ghanaian market are 1-star rated with an average EER of 2.87, which is above the minimum EER of 2.80 with an average annual rated power consumption of 3347.4 kWh [37]. Also, 56% of the RACs were laden with R410a refrigerant which is more energy-efficient than R22 [40]. The average annual energy consumption of a used RAC is 4000 kWh per year [39]. Therefore, 652.6 kWh of electricity has been saved per unit per year due to MEPS. Assuming that 90% of the new RACs were sold between 2014 and 2020. Figure 8 presents the analysis of the total electricity and CO2 emission savings using Eqs. (1)–(3). From the analysis, about 1900 GWh electricity has been saved with a corresponding 783,000 tonnes of CO2 emission savings resulting from MEPS due to L.I. 1815 enforcement.
Analysis of total electricity and CO2 emission savings for RACs.
Analysis of some of the reports at the Ghana Energy Commission indicated that the compliance levels of the refrigerating appliances and RACs have been increasing over the years. Between 2017 and 2020, the compliance level of the imported refrigerating appliance increased from 92.6% to 97.0% whilst that of RACs also saw an upsurge from 79.2% to 96.8% [37, 39]. Figure 9 shows the trends in the compliance levels of these appliances from 2017 to 2020.
Trends in compliance levels for refrigerating appliances and RACs from 2017 to 2020.
The analysis further revealed that the following factors contributed to the high compliance levels in an attempt to transform the appliance market in Ghana [37, 39]:
Submission of performance test report by importers from third-party accredited laboratories to the Ghana Energy Commission for evaluation and approval or otherwise;
Establishment of import appliance database/register;
Operationalization of the GCNet/ICUMS digital portals for approving only appliances that meet MEPS;
Rigorous physical examination procedures/protocols put in place at the ports of entry;
Regular and consistent market surveillance;
Stringent compliance monitoring;
Removal of non-compliant appliances from showrooms for testing and re-labelling;
Payment of enforcement fees for non-compliance;
Verification and challenge testing procedures; and
Development of a Certified Appliances Mobile Application (APP) which contains all the approved appliances, nearby shops, tips on how to save energy. This APP also helps consumers to make an informed purchase decision. To download the APP, retailers and consumers are required to search for
Ghana’s drive to transform the appliance market from the used and inefficient appliances to new and efficient ones has been highly recommended over the years. From this review or study, Ghana developed and implemented MEPS successfully for refrigerating appliances, RACs and lighting systems. This was done through the engagement of relevant stakeholders with complementary financial and technical assistance from development partners. Through MEPS implementation, annual average energy consumptions of refrigerating appliances and RACs have decreased drastically. The implementation of MEPS programmes in Ghana during the period under review yielded 8317.8 GWh (8.32 TWh) of electricity savings, while at the same time reducing fossil CO2 emissions by 4.60 million tonnes. This figure roughly corresponds to the total thermal electricity generated (8424 GWh) in 2017 [6]. At 10 US cents per kWh, about USD 832 million has been saved on electricity bills. This enormous financial saving and environmental benefit resulting from deferred electricity consumption amplifies the positive implication of energy efficiency and MEPS programmes. In conclusion, the implementation of energy efficiency programmes delayed the construction of a 950 MW power plant capacity. The 17 other regulations that are currently being developed for other electrical equipment such as television sets, electric motors, washing machines, blenders, etc. must be concluded in good time to enable further energy savings for the country.
I would like to thank the following organizations that contributed valuable information on the subject: Ghana Energy Commission, Energy Foundation, Council for Scientific and Industrial Research—Institute of Industrial Research, Ghana Revenue Authority, International Energy Agency (IEA), European Union (EU), Collaborative Labelling and Appliance Standards Program (CLASP) and Lawrence Berkeley National Laboratory (LBNL).
The author, Edwin Kwasi Tamakloe is an employee of the Ghana Energy Commission which is one of the stakeholder institutions discussed in the article. This is indicated transparently in the author affiliations.
See Figure A1.
Sample of a three (3) star rated energy guide label for refrigerating appliance in Ghana [
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",metaTitle:"Advertising Policy",metaDescription:"IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.",metaKeywords:null,canonicalURL:"/page/advertising-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\\n\\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\\n\\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
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\\n\\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\\n\\n9. Types of advertisments:
\\n\\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\\n\\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\\n\\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\\n\\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\\n\\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\\n\\nPolicy last updated: 2021-04-28
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\n\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\n\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\n\n4. IntechOpen has blocked all the inappropriate types of advertising.
\n\n5. IntechOpen has blocked advertisement of harmful products or services.
\n\n6. Advertisements and editorial content are clearly distinguishable.
\n\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\n\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\n\n9. Types of advertisments:
\n\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\n\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\n\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\n\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\n\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\n\nPolicy last updated: 2021-04-28
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The stigma associated with substance use disorder is prevalent, which leads to significant biases, even in the healthcare system. This bias is heightened when IVDU patients require repeat valve replacement surgeries for IE due to continued drug use. Patients who receive a valve replacement and continue to use illicit drugs intravenously often return to their medical providers, months to a few years later, with a reinfection of their bioprosthetic valve; such patients require additional surgeries which are at the center of many ethical discussions due to high mortality rates, for many complex medical and social reasons, associated with continuous chemical dependency after surgical interventions. This chapter examines the ethics of repeat heart valve replacement surgery for patients who are struggling with addiction. 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By 19th century, the transplantation concept become possible by extensive contributions from scientists and clinicians whose works had taken generations. Although Alexis Carrel is known as the founding father of experimental organ transplantation, many legendary names had contributed to the experimental works of heart transplantation, including Guthrie, Mann, and Demikhov. The major contribution to experimental heart transplantation before the clinical era were made by a team lead by Richard Lower and Norman Shumway at Stanford University in the early 1960s. They played the vital role in developing experimental and clinical heart transplantation as it is known today. Using Shumway biatrial technique Christiaan Barnard started a new era of clinical heart transplantation, by performing the first in man human-to-human heart transplantation in 1967. The techniques of heart transplant have evolved since the first heart transplant. This chapter will summarize the techniques that have been used in clinical heart transplantation.",book:{id:"11236",slug:null,title:"Heart Transplantation - New Insights in Therapeutic Strategies",fullTitle:"Heart Transplantation - New Insights in Therapeutic Strategies"},signatures:"Samuel Jacob, Anthony N. Pham and Si M. Pham",authors:null},{id:"70032",title:"Coronary Artery Bypass Grafting: Surgical Anastomosis: Tips and Tricks",slug:"coronary-artery-bypass-grafting-surgical-anastomosis-tips-and-tricks",totalDownloads:1361,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"The definite feature of coronary artery disease is the focal narrowing in the vascular endothelium, and this leads to the decrease in the flow of blood to the myocardium. Atherosclerotic plaque is the main lesion. These patients can present with chest pain (angina or myocardial infarction) and need further workup noninvasively and invasively for the management. The main reasons for myocardial revascularization can be: (1) relief from symptoms of myocardial ischemia; (2) reduce the risks of future mortality; (3) to treat or prevent morbidities such as myocardial infarction, arrhythmias, or heart failure. Coronary artery bypass grafting (CABG) is the surgical technique of cardiac revascularization. In 1910, Dr. Alexis Carrel described a series of canine experiments in which he devised means to treat CAD by creating a “complementary circulation” for the diseased native coronary arteries. No clinical translation occurred at the time, but he was awarded the Nobel Prize in Medicine. Experimental refinements of coronary arterial revascularization, including the use of internal thoracic artery (ITA) grafts, were later reported by Murray and colleagues, Demikhov, and Goetz and colleagues in the 1950s and early 1960s. Dr. Rene Favaloro performed his first coronary bypass operation in May 1967 with an interposed saphenous vein graft (SVG) and shortly thereafter used aortocoronary bypasses sutured proximally to the ascending aorta. The stenosed segment is bypassed using an arterial or venous graft. Left internal thoracic artery is the most commonly used artery, and long saphenous vein is the most commonly used vein for the coronary artery grafting to reestablish the blood flow to the compromised myocardium. This can be performed with or without the help of cardiopulmonary bypass machine and also with or without arresting the heart. These techniques are called as on-pump beating or on-pump arrested and off-pump beating coronary artery bypass grafting surgery. Distal and proximal anastomoses are usually performed in an end-to-side manner, but in the case of doing sequential grafting, side-to-side anastomosis is also performed proximal to the end-to-side anastomosis. In this chapter we are going to discuss the coronary artery bypass grafting tips and tricks in details.",book:{id:"9060",slug:"the-current-perspectives-on-coronary-artery-bypass-grafting",title:"The Current Perspectives on Coronary Artery Bypass Grafting",fullTitle:"The Current Perspectives on Coronary Artery Bypass Grafting"},signatures:"Mohd. Shahbaaz Khan",authors:[{id:"278633",title:"Dr.",name:"Mohd. Shahbaaz",middleName:null,surname:"Khan",slug:"mohd.-shahbaaz-khan",fullName:"Mohd. Shahbaaz Khan"}]},{id:"65984",title:"Low Flow Low Gradient Severe Aortic Stenosis: Diagnosis and Treatment",slug:"low-flow-low-gradient-severe-aortic-stenosis-diagnosis-and-treatment",totalDownloads:2213,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Approximately 40% of patients with aortic stenosis (AS) show discordant Doppler-echocardiographic parameters with aortic valve area (AVA) <1 cm2 and/or index iAVA <0.6 cm2/m2 (consistent with severe AS) and the mean gradient (MG) <40 mmHg, consistent with mild/moderate AS. Accurate diagnosis of true severe low flow low gradient AS versus pseudo-severe aortic stenosis is important for prognosis and optimal timing for intervention. Doppler echocardiography using intravenous low dose dobutamine challenge is widely used for differentiating pseudo-severe from true severe aortic stenosis. However, relying on echocardiography alone may have limitations in accurate diagnosis. Reliable diagnosis using echocardiography is dependent on multiple factors like the angle of interrogation of the aortic jet, the assumption that the LVOT area is circular in cross section, optimal echo windows, the presence of underlying subclinical coronary artery disease prior to dobutamine challenge etc. In this chapter, we describe non-invasive and invasive strategies to assess the aortic valve using dobutamine stress. Direct measurement of gradients across the aortic valve while estimating the change in cardiac output and aortic valve area with increments of dobutamine infusion dose is complementary, safe and useful when conventional echocardiography techniques are inconclusive. Finally, the chapter describes effective strategies of treatment for low gradient severe aortic stenosis, including the role for diagnostic balloon valvuloplasty, in the era of transcatheter valve replacement (TAVR).",book:{id:"8218",slug:"aortic-stenosis-current-perspectives",title:"Aortic Stenosis",fullTitle:"Aortic Stenosis - Current Perspectives"},signatures:"Faeez Mohamad Ali, Vindhya Wilson and Rajesh Nair",authors:[{id:"280651",title:"Dr.",name:"Rajesh",middleName:null,surname:"Nair",slug:"rajesh-nair",fullName:"Rajesh Nair"},{id:"280829",title:"Dr.",name:"Faeez",middleName:null,surname:"Mohamad Ali",slug:"faeez-mohamad-ali",fullName:"Faeez Mohamad Ali"},{id:"290351",title:"Dr.",name:"Vindhya",middleName:null,surname:"Wilson",slug:"vindhya-wilson",fullName:"Vindhya Wilson"}]},{id:"59547",title:"Left Ventricular Assist Device Infections",slug:"left-ventricular-assist-device-infections",totalDownloads:1466,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Left ventricular assist device (LVAD) infections are important causes of morbidity and mortality in patients who receive these mechanical circulatory supports as a bridge to transplantation (BTT) or as destination therapy (DT) (for individuals who are not candidates for cardiac transplant). Infections are more common among persons who received pulsatile flow LVADs as opposed to newer continuous flow (CF) devices. Other risk factors for infection include obesity, renal failure, depression and immunosuppression. An LVAD infection increases the risk of infections in persons who undergo cardiac transplantation. Infections include percutaneous site, driveline, pump pocket and pump/cannula infections; sepsis, bacteremia, mediastinitis and endocarditis. Diagnosis is achieved by monitoring LVAD flow parameters and observing typical clinical and laboratory manifestations of infection. Imaging such as PET-CT or SPECT-CT imaging can be helpful to establish a diagnosis of pump pocket infection. Echocardiography may aid in detecting native valve endocarditis and thrombus associated with the LVAD. The most common pathogens include Staphylococcus, Corynebacterium, Enterococcus, Pseudomonas and Candida spp. Treatment requires targeted antimicrobials plus surgical debridement of infected tissue and device components. In cases of pump/cannula/LVAD endocarditis, especially if fungal pathogens or Mycobacterium chimaera are involved, LVAD removal/reimplantation vs. transplant is necessary, combined with extended antimicrobial therapy.",book:{id:"6556",slug:"advanced-concepts-in-endocarditis",title:"Advanced Concepts in Endocarditis",fullTitle:"Advanced Concepts in Endocarditis"},signatures:"Marion J. Skalweit",authors:[{id:"186717",title:"Associate Prof.",name:"Marion",middleName:null,surname:"Skalweit",slug:"marion-skalweit",fullName:"Marion Skalweit"}]},{id:"60658",title:"Humoral Rejection in Cardiac Transplantation: Management of Antibody-Mediated Rejection",slug:"humoral-rejection-in-cardiac-transplantation-management-of-antibody-mediated-rejection",totalDownloads:1083,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"After a successful heart transplantation, fundamental keys to achieve good results in the long term are to establish immunosuppressive therapy in the postoperative period in an appropriate manner and to ensure continuity of follow-ups. Despite the fact that these stages are maintained perfectly, patients may face one or more rejection episodes. T-cell-mediated acute cellular rejection of the cardiac allograft has well-established treatment algorithms, whereas antibody-mediated rejection (AMR) is challenging to diagnose, and its treatment varies between centers. Investigators reported that AMR is among the most important factors to improving long-term outcomes. Improved understanding of the roles of acute and chronic AMR has evolved in recent years following a major progress in the technical ability to detect and quantify recipient antihuman leukocyte antigen (HLA) antibody production. Recently, a study of the immunobiology of B cells and plasma cells that pertains to allograft rejection and tolerance has emerged. There are some questions regarding the classification of AMR, the diagnostic approaches, and the treatment strategies for managing. In this chapter, we are discuss the effector mechanisms that are used by antibodies to eliminate antigens and clinical experience about AMR and its treatment with a discussion about the latest articles.",book:{id:"6558",slug:"heart-transplantation",title:"Heart Transplantation",fullTitle:"Heart Transplantation"},signatures:"Umit Kervan, Dogan Emre Sert and Nesrin Turan",authors:[{id:"227772",title:"Prof.",name:"Umit",middleName:null,surname:"Kervan",slug:"umit-kervan",fullName:"Umit Kervan"},{id:"243592",title:"Dr.",name:"Dogan Emre",middleName:null,surname:"Sert",slug:"dogan-emre-sert",fullName:"Dogan Emre Sert"},{id:"243593",title:"Dr.",name:"Nesrin",middleName:null,surname:"Turan",slug:"nesrin-turan",fullName:"Nesrin Turan"}]}],onlineFirstChaptersFilter:{topicId:"984",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81437",title:"Pediatric Heart Transplantation",slug:"pediatric-heart-transplantation",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.104518",abstract:"Despite advances in medical management, patients submitted for heart transplantation procedures still are at risk to development of complications. This chapter will discuss some specific topics of pediatric heart transplantation, focusing on perioperative care: (i) recipient management, (ii) donor evaluation, (iii) immunosuppression, (iv) early postoperative management, (v) complications, and (vi) conclusions.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Estela Azeka"},{id:"81451",title:"Donor Assessment and Management for Heart Transplantation",slug:"donor-assessment-and-management-for-heart-transplantation",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104504",abstract:"For many years, heart transplantation has been an established procedure for patients with end-stage heart failure using the so-called “Standard Criteria” for an optimal heart donor. However, annually listed patients for heart transplantation greatly increased worldwide, and the use of extended criteria donor hearts has been utilized as many as possible in many countries. In this chapter, firstly, pathophysiology of brain death is explained. Secondly, donor assessment and issues of extended criteria donors are introduced. Then, donor management to maximize the heart graft availability, and the Japanese donor assessment and evaluation system and its outcome are reviewed.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Norihide Fukushima"},{id:"81057",title:"Induction Therapy in the Current Immunosuppressive Therapy",slug:"induction-therapy-in-the-current-immunosuppressive-therapy",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.103746",abstract:"The current immunosuppressive therapy including calcineurin inhibitors, mycophenolate mofetil, and steroids, has substantially suppress rejections and improved clinical outcomes in heart transplant (HTx) recipients. Nevertheless, the management of drug-related nephrotoxicity, fatal acute cellular rejection (ACR), antibody-mediated rejection and infections remains challenging. Although previous some studies suggested that perioperative induction immunosuppressive therapy may be effective for the suppressing ACR and deterioration of renal function, increased incidence of infection and malignancy was concerned in recipients with induction immunosuppressive therapy. The international society of heart and lung transplantation (ISHLT) guidelines for the care of heart transplant recipients do not recommend routine use of induction immunosuppressive therapy, except for the patients with high risk of acute rejection or renal dysfunction, however, appropriate therapeutic regimen and indication of induction immunosuppressive therapy remains unclear in HTx recipients. We review current evidence of induction immunosuppressive therapy in HTx recipients, and discuss the appropriate therapeutic regimen and indication of induction therapy.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Takuya Watanabe, Yasumasa Tsukamoto, Hiroki Mochizuki, Masaya Shimojima, Tasuku Hada, Satsuki Fukushima, Tomoyuki Fujita and Osamu Seguchi"},{id:"80305",title:"Hepatic and Endocrine Aspects of Heart Transplantation",slug:"hepatic-and-endocrine-aspects-of-heart-transplantation",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.102418",abstract:"End-organ dysfunction is a progression that can often develop in patients with end-stage heart failure. Hepatic abnormalities in advanced systolic heart failure may affect several aspects of the liver function. Hepatic function is dependent on age, nutrition, previous hepatic diseases, and drugs. The hepatic dysfunction can have metabolic, synthetic, and vascular consequences, which strongly influence the short- and long-term results of the transplantation. In this chapter, the diagnostic and treatment modalities of the transplanted patient will be discussed. On the other hand, endocrine abnormalities, particularly thyroid dysfunction, are also frequently detected in patients on the waiting list. Endocrine supplementation during donor management after brain death is crucial. Inappropriate management of central diabetes insipidus, hyperglycemia, or adrenal insufficiency can lead to circulatory failure and graft dysfunction during procurement. Thyroid dysfunction in donors and recipients is conversely discussed.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Andrea Székely, András Szabó and Balázs Szécsi"},{id:"79970",title:"The Role of Large Impella Devices in Temporary Mechanical Circulatory Support for Patients Undergoing Heart Transplantation",slug:"the-role-of-large-impella-devices-in-temporary-mechanical-circulatory-support-for-patients-undergoin",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.101680",abstract:"Large microaxial pump systems (Impella 5.0, or Impella 5.5; i.e., Impella 5+) (Abiomed Inc., Danvers, MA, USA) have gained increasing levels of attendance as valuable tools of mechanical circulatory support (MCS). Patients undergoing heart transplantation (HTX) often need temporary MCS in the perioperative course, either as a preoperative bridge or occasionally in the early post-transplant period. Here we present our experience using Impella 5+ support for patients designated to undergo HTX, describe technical aspects of implantation and removal, and further analyze factors influencing the overall patient outcome. Significant factors are discussed in front of the background of contemporary international literature, and current scientific questions are highlighted.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Yukiharu Sugimura, Sebastian Bauer, Moritz Benjamin Immohr, Arash Mehdiani, Hug Aubin, Ralf Westenfeld, Udo Boeken, Artur Lichtenberg and Payam Akhyari"},{id:"80721",title:"Gene Therapy for Cardiac Transplantation",slug:"gene-therapy-for-cardiac-transplantation",totalDownloads:85,totalDimensionsCites:0,doi:"10.5772/intechopen.102865",abstract:"Gene therapy is an advanced treatment approach that alters the genetic composition of cells to confer therapeutic protein or RNA expression to the target organ. It has been successfully introduced into clinical practice for the treatment of various diseases. Cardiac transplantation stands to benefit from applications of gene therapy to prevent the onset of post-transplantation complications, such as primary graft dysfunction, cardiac allograft vasculopathy, and rejection. Additionally, gene therapy can be used to minimize or potentially eliminate the need for immunosuppression post-transplantation. Several animal models and delivery strategies have been developed over the years with the goal of achieving robust gene expression in the heart. However, a method for doing this has yet to be successfully translated into clinical practice. The recent advances in ex vivo perfusion for organ preservation provide potential ways to overcome several barriers to achieving gene therapy for cardiac transplantation into clinical practice. Optimizing the selection of the gene-carrying vector for gene delivery and selection of the therapeutic gene to be conferred is also crucial for being able to implement gene therapy in cardiac transplantation. Here, we discuss the history and current state of research on gene therapy for cardiac transplantation.",book:{id:"11236",title:"Heart Transplantation - New Insights in Therapeutic Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11236.jpg"},signatures:"Michelle Mendiola Pla, Yuting Chiang, Jun-Neng Roan and Dawn E. Bowles"}],onlineFirstChaptersTotal:13},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. 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settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"38",type:"subseries",title:"Pollution",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment",scope:"\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",slug:"meng-chuan-ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",slug:"olga-anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},onlineFirstChapters:{paginationCount:20,paginationItems:[{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. 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He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry"}}},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:318,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). 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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/128831",hash:"",query:{},params:{id:"128831"},fullPath:"/profiles/128831",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()