\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"9377",leadTitle:null,fullTitle:"Non-Coding RNAs",title:"Non-Coding RNAs",subtitle:null,reviewType:"peer-reviewed",abstract:"Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.",isbn:"978-1-78985-656-9",printIsbn:"978-1-78985-655-2",pdfIsbn:"978-1-78985-708-5",doi:"10.5772/intechopen.84808",price:119,priceEur:129,priceUsd:155,slug:"non-coding-rnas",numberOfPages:148,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"ff4f15e339216fa9426d2b9fdf3b5901",bookSignature:"Lütfi Tutar, Sümer Aras and Esen Tutar",publishedDate:"March 4th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9377.jpg",numberOfDownloads:7315,numberOfWosCitations:3,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:16,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:22,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 11th 2019",dateEndSecondStepPublish:"April 26th 2019",dateEndThirdStepPublish:"June 25th 2019",dateEndFourthStepPublish:"September 13th 2019",dateEndFifthStepPublish:"November 12th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"158530",title:"Dr.",name:"Lütfi",middleName:null,surname:"Tutar",slug:"lutfi-tutar",fullName:"Lütfi Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158530/images/system/158530.png",biography:"Dr. Lütfi Tutar is currently an assistant professor at the Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Kırşehir Ahi Evran University, Turkey. His interdisciplinary research focuses on bioinformatics analysis of high-throughput data, microRNAs, small RNAs, and Heat Shock Proteins (HSPs) in human diseases and other multicellular organisms.",institutionString:"Kırşehir Ahi Evran University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"40615",title:"Prof.",name:"Sumer",middleName:null,surname:"Aras",slug:"sumer-aras",fullName:"Sumer Aras",profilePictureURL:"https://mts.intechopen.com/storage/users/40615/images/system/40615.jpg",biography:"Sümer Aras was educated at the Middle East Technical University,\nBiology Department, Ankara, Turkey, and obtained her BS degree\nin 1988. She finished her Master of Science studies at Cleveland\nState University and Cleveland Clinic Foundation, Department\nof Molecular Biology, Ohio, USA, in 1994. She obtained her PhD\ndegree in 1998 at Ankara University. Her area of interest is plant\nmolecular biology and biotechnology. She has more than 140 publications in the field of molecular biology of which 70 are full text articles in respected\njournals. Currently, she works as a full professor at Ankara University in the Biology\nDepartment. She is also Chair of the Biotechnology Section.",institutionString:"Ankara University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"295100",title:"Dr.",name:"Esen",middleName:null,surname:"Tutar",slug:"esen-tutar",fullName:"Esen Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/295100/images/system/295100.jpg",biography:"Dr. Esen Tutar is currently an assistant professor at Kırşehir Ahi\nEvran University (Mucur Health Services Vocational School, Department of Medical Services and Techniques, Medical Laboratory Techniques Program), Kırşehir, Turkey. Her research focuses\non microRNAs, non-coding RNAs, molecular identification of\nmicrobial pathogens, and heat shock proteins.",institutionString:"Kırşehir Ahi Evran University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Ahi Evran University",institutionURL:null,country:{name:"Turkey"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"396",title:"Molecular Genetics",slug:"genomics-molecular-genetics"}],chapters:[{id:"71032",title:"Introductory Chapter: Noncoding RNAs—A Brief Overview",doi:"10.5772/intechopen.91332",slug:"introductory-chapter-noncoding-rnas-a-brief-overview",totalDownloads:638,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sümer Aras, Esen Tutar and Lütfi Tutar",downloadPdfUrl:"/chapter/pdf-download/71032",previewPdfUrl:"/chapter/pdf-preview/71032",authors:[{id:"158530",title:"Dr.",name:"Lütfi",surname:"Tutar",slug:"lutfi-tutar",fullName:"Lütfi Tutar"},{id:"40615",title:"Prof.",name:"Sumer",surname:"Aras",slug:"sumer-aras",fullName:"Sumer Aras"},{id:"295100",title:"Dr.",name:"Esen",surname:"Tutar",slug:"esen-tutar",fullName:"Esen Tutar"}],corrections:null},{id:"69180",title:"MicroRNA-335-5p and Gastrointestinal Tumors",doi:"10.5772/intechopen.88895",slug:"microrna-335-5p-and-gastrointestinal-tumors",totalDownloads:988,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Noncoding genomics, i.e., microRNAs and long coding RNAs (lncRNA), is an emerging topic in gastrointestinal tumors. In particular, the coordinate deregulation of miRNA-335-5p across these tumors and its potential clinical applications is an example of this scenario. This chapter discusses the pathogenetic role of miRNA-335-5p in esophageal, gastric, colon, liver, gallbladder, and pancreatic tumors. This pathogenetic role is examined in the context of the competing endogenous network, the language through lncRNA that reduce the quantity of miRNA available to target mRNA. The translational application of miRNA-335-5p, through the aberrant methylation of the promoter region of MEST—its host gene—as a potential biomarker for noninvasive detection of gastric cancer, is also discussed.",signatures:"Pablo M. Santoro, Alejandra Sandoval-Bórquez and Alejandro H. Corvalan",downloadPdfUrl:"/chapter/pdf-download/69180",previewPdfUrl:"/chapter/pdf-preview/69180",authors:[{id:"53562",title:"Prof.",name:"Alejandro",surname:"Corvalan",slug:"alejandro-corvalan",fullName:"Alejandro Corvalan"},{id:"297069",title:"Dr.",name:"Alejandra",surname:"Sandoval",slug:"alejandra-sandoval",fullName:"Alejandra Sandoval"},{id:"308428",title:"Mr.",name:"Pablo",surname:"Santoro",slug:"pablo-santoro",fullName:"Pablo Santoro"}],corrections:null},{id:"67642",title:"Role of MicroRNA in Smoking–Induced Periodontitis",doi:"10.5772/intechopen.86756",slug:"role-of-microrna-in-smoking-induced-periodontitis",totalDownloads:727,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Stem cells participate in tissue restoration and therapies. The oral cavity, the site of smoking exposure, contains stem cells which are involved in the development, maintenance, and repair of oral tissues. By residing in the oral cavity, stem cells are exposed to and susceptible to the effects of smoking. Periodontitis has been associated with increased incidences of other illnesses such as cardiovascular diseases. We hypothesis that smoking suppression of stem cell potentials by miRNAs is a separate and independent pathway than the pathway via the nicotine receptor activation. Smoking perturbs miRNA expression, resulting in decreased stem cell regeneration potential that delays healing of periodontitis.",signatures:"Herman S. Cheung, Carlos Carballosa and Jordan Greenberg",downloadPdfUrl:"/chapter/pdf-download/67642",previewPdfUrl:"/chapter/pdf-preview/67642",authors:[{id:"60386",title:"Dr.",name:"Herman S.",surname:"Cheung",slug:"herman-s.-cheung",fullName:"Herman S. Cheung"},{id:"297294",title:"Dr.",name:"Carlos",surname:"Carballosa",slug:"carlos-carballosa",fullName:"Carlos Carballosa"},{id:"318649",title:"Dr.",name:"Jordan",surname:"Greenberg",slug:"jordan-greenberg",fullName:"Jordan Greenberg"}],corrections:null},{id:"69556",title:"Role of Virus-Encoded microRNAs in Avian Viral Diseases",doi:"10.5772/intechopen.89688",slug:"role-of-virus-encoded-micrornas-in-avian-viral-diseases",totalDownloads:759,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"To survive in the host cells, viruses have to adapt various strategies, which include the modulation of microRNA (miRNA) pathway through virus-encoded miRNAs to modulate the host cellular environment. It has been shown that several avian viruses, mostly herpesviruses, encode a number of miRNAs. These include 26 miRNAs encoded by the highly oncogenic Marek’s disease virus-1, 36 miRNAs encoded by avirulent Marek’s disease virus-2, 28 miRNAs by herpesvirus of turkeys, 10 miRNAs by infectious laryngotracheitis virus, 41 miRNAs by duck enteritis virus, and 2 miRNAs by avian leukosis virus subgroup J. Although locations of some of the miRNAs are conserved within the repeat regions of the genomes among some of the antigenic and phylogenetic closely related herpesviruses, there are no sequence conservation of miRNAs encoded by different avian herpesviruses. Moreover, some of the virus-encoded miRNAs have the same seed sequence as host miRNAs serve as functional orthologs. For example, mdv1-miR-M4-5p, a functional ortholog of gga-miR-155, is critical for the Marek’s disease virus in inducing tumors. In this review, we describe the advances in our understanding on the role of the herpesvirus-encoded miRNAs in avian diseases. Additionally, we also describe the potential association of avian leukosis virus subgroup J encoded E (XSR) miRNA in the induction of myeloid tumors in certain genetically distinct chicken lines.",signatures:"Venugopal Nair and Yongxiu Yao",downloadPdfUrl:"/chapter/pdf-download/69556",previewPdfUrl:"/chapter/pdf-preview/69556",authors:[{id:"297499",title:"Dr.",name:"Yongxiu",surname:"Yao",slug:"yongxiu-yao",fullName:"Yongxiu Yao"},{id:"305518",title:"Prof.",name:"Venugopal",surname:"Nair",slug:"venugopal-nair",fullName:"Venugopal Nair"}],corrections:null},{id:"69509",title:"MicroRNAs in the Functional Defects of Skin Aging",doi:"10.5772/intechopen.89689",slug:"micrornas-in-the-functional-defects-of-skin-aging",totalDownloads:949,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Humankind has always been intrigued by death, as illustrated by the eternal quest for the fountain of youth. Aging is a relentless biological process slowly progressing as life cycle proceeds. Indeed, aging traduces an accumulation of physiological changes over time that render organisms more likely to die. Thus, despite our mastery of advanced technologies and robust medical knowledge, defining the molecular basis of aging to control lifespan is still currently one of the greatest challenges in biology. In mammals, the skin is the ultimate multitasker vital organ, protecting organisms from the world they live in. As a preferential interface with the environment, the skin is reflecting the internal physiological balances. The maintenance of these balances, called homeostasis, depends on the concurrent assimilation of diversified signals at the cellular level. MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression by mRNAs degradation or translational repression. Their relatively recent discovery in 2000 provided new insights into the understanding of the gene regulatory networks. In this chapter, we focused on the role of three miRNA families, namely miR-30, miR-200, and miR-181, playing a key role in the progression of the skin aging process, with particular input in mechanistic considerations related to autophagy, oxidative stress, and mitochondrial homeostasis.",signatures:"Fabien P. Chevalier, Julie Rorteau and Jérôme Lamartine",downloadPdfUrl:"/chapter/pdf-download/69509",previewPdfUrl:"/chapter/pdf-preview/69509",authors:[{id:"101931",title:"Prof.",name:"Jérôme",surname:"Lamartine",slug:"jerome-lamartine",fullName:"Jérôme Lamartine"},{id:"297823",title:"Dr.",name:"Fabien",surname:"Chevalier",slug:"fabien-chevalier",fullName:"Fabien Chevalier"},{id:"309924",title:"Ph.D. Student",name:"Julie",surname:"Rorteau",slug:"julie-rorteau",fullName:"Julie Rorteau"}],corrections:null},{id:"68010",title:"MicroRNA-Based Markers in Plant Genome Response to Abiotic Stress and Their Application in Plant Genotyping",doi:"10.5772/intechopen.88064",slug:"microrna-based-markers-in-plant-genome-response-to-abiotic-stress-and-their-application-in-plant-gen",totalDownloads:746,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The high conservation of miRNA sequences provided an opportunity to develop an effective type of markers that is useful not only for genetic diversity study but also as potential biomarkers in plant stress responses. The fundamental potential of miRNA-based markers relies on the primer design based on the sequences of mature miRNAs, which are part of the step-loop structures. The advantages of this marker system include high polymorphism, reproducibility, and transferability across species. The abundance of mature miRNAs, which is linked to the expression of MIRNA genes, varies greatly among miRNAs, tissue types, or developmental stages, indicating the spatially and temporally regulated expression patterns of plant miRNAs. The results confirm the significance, reliability, and the position of miRNA-based markers as stress-sensitive biomarkers, indicating their potential in a wide range of applications of agricultural research.",signatures:"Katarína Ražná, Jana Žiarovská and Zdenka Gálová",downloadPdfUrl:"/chapter/pdf-download/68010",previewPdfUrl:"/chapter/pdf-preview/68010",authors:[{id:"257512",title:"Dr.",name:"Jana",surname:"Žiarovská",slug:"jana-ziarovska",fullName:"Jana Žiarovská"},{id:"298187",title:"Associate Prof.",name:"Katarína",surname:"Ražná",slug:"katarina-razna",fullName:"Katarína Ražná"},{id:"298189",title:"Dr.",name:"Zdenka",surname:"Gálová",slug:"zdenka-galova",fullName:"Zdenka Gálová"}],corrections:null},{id:"68344",title:"The Role of Noncoding RNAs in Brain Cells during Rat Cerebral Ischemia",doi:"10.5772/intechopen.88402",slug:"the-role-of-noncoding-rnas-in-brain-cells-during-rat-cerebral-ischemia",totalDownloads:670,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Ischemic brain stroke is one of the most serious and socially important medical conditions. Transcriptome analysis is a prospective approach to the study of the mechanisms of brain functioning, both under normal conditions and in ischemia. In addition to mRNA encoding proteins, the study of noncoding RNAs in ischemia has exceptional importance for the development of new strategies for neuroprotection. Of greatest interest are microRNAs (miRNAs) and circular RNAs (circRNAs). circRNAs have a closed structure and predominantly brain-specific expression. They can interact with miRNAs, diminish their activity, and thereby inhibit miRNA-mediated repression of mRNA. Recently, it has become clear that the analysis of circRNA-miRNA-mRNA interactions is an important requirement for the detailed study of the mechanisms of damage and regeneration during ischemia. This chapter reviews the most recent data on the role of circRNAs, miRNAs, mRNAs, and their interactions in brain cells under normal conditions and in cerebral ischemia.",signatures:"Ivan B. Filippenkov, Lyudmila V. Dergunova and Svetlana A. Limborska",downloadPdfUrl:"/chapter/pdf-download/68344",previewPdfUrl:"/chapter/pdf-preview/68344",authors:[{id:"41925",title:"Dr.",name:"Svetlana",surname:"Limborska",slug:"svetlana-limborska",fullName:"Svetlana Limborska"},{id:"301808",title:"Ph.D.",name:"Ivan",surname:"Filippenkov",slug:"ivan-filippenkov",fullName:"Ivan Filippenkov"},{id:"302027",title:"Dr.",name:"Lyudmila",surname:"Dergunova",slug:"lyudmila-dergunova",fullName:"Lyudmila Dergunova"}],corrections:null},{id:"69297",title:"lncRNAs in Hallmarks of Cancer and Clinical Applications",doi:"10.5772/intechopen.88903",slug:"lncrnas-in-hallmarks-of-cancer-and-clinical-applications",totalDownloads:786,totalCrossrefCites:1,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides in length that, in general, do not appear to have protein-coding potential. lncRNAs act in gene regulation involved with several biological processes. Furthermore, lncRNAs have been associated with a significant number of cancers, suggesting a potential role in tumorigenesis and progression. For example, HOTAIR regulates proliferation processes and other lncRNAs like highly upregulated in liver cancer (HULC), H19, PTENP1, HEIH, and antisense noncoding RNA in the INK4 locus (ANRIL). Other lncRNAs as AFAP1-AS1 and lincRNA-p21 can interact with BCL-2 and TP53, acting in apoptosis. Moreover, NORAD plays a vital role in genomic stability. Additionally, due to deregulated expression and high tissue specificity level, lncRNAs exhibit great potential as prognostic markers. In this chapter, we review the most highlighted lncRNAs acting in hallmarks of cancer and clinical application.",signatures:"Leandro Garcia, Erika Zambalde, Carolina Mathias, Jéssica Barazetti, Daniela Gradia and Jaqueline Oliveira",downloadPdfUrl:"/chapter/pdf-download/69297",previewPdfUrl:"/chapter/pdf-preview/69297",authors:[{id:"302818",title:"Ph.D.",name:"Jaqueline",surname:"Oliveira",slug:"jaqueline-oliveira",fullName:"Jaqueline Oliveira"},{id:"302822",title:"Prof.",name:"Daniela",surname:"Gradia",slug:"daniela-gradia",fullName:"Daniela Gradia"},{id:"302823",title:"Dr.",name:"Leandro",surname:"Garcia",slug:"leandro-garcia",fullName:"Leandro Garcia"},{id:"302824",title:"MSc.",name:"Carolina",surname:"Mathias",slug:"carolina-mathias",fullName:"Carolina Mathias"},{id:"308943",title:"MSc.",name:"Erika",surname:"Zambalde",slug:"erika-zambalde",fullName:"Erika Zambalde"},{id:"308945",title:"MSc.",name:"Jéssica",surname:"Barazetti",slug:"jessica-barazetti",fullName:"Jéssica Barazetti"}],corrections:null},{id:"68146",title:"The Function of lncRNAs as Epigenetic Regulators",doi:"10.5772/intechopen.88071",slug:"the-function-of-lncrnas-as-epigenetic-regulators",totalDownloads:1054,totalCrossrefCites:1,totalDimensionsCites:8,hasAltmetrics:1,abstract:"Recently, the non-coding RNAs (ncRNAs) have been classified in different categories, and its importance in regulating different cellular processes has been unravelled. The long non-coding RNAs (lncRNAs) can interact with DNA, other RNAs and proteins, including epigenetic modifiers. Some lncRNAs are related to genomic imprinting and are associated with chromatin-modifying complexes that can regulate gene transcription. It is well established that cancer cells have different epigenetic alterations and some of these modifications are associated with lncRNAs. Studies of cancer-associated lncRNAs have defined its function in the process of tumorigenesis, its impact on cell proliferation, cellular signalling, angiogenesis and metastasis. Therefore, having a better knowledge of their role might contribute to a better understanding of the diseases. In this chapter, we will discuss about lncRNA classification and functions, epigenetic marks and how they can guide transcription. Nevertheless, we will discuss how these mechanisms can interact and guide gene expression, as well as recently findings of dysregulation of lncRNAs in cancer.",signatures:"Ana Luisa Pedroso Ayub, Debora D’Angelo Papaiz, Roseli da Silva Soares and Miriam Galvonas Jasiulionis",downloadPdfUrl:"/chapter/pdf-download/68146",previewPdfUrl:"/chapter/pdf-preview/68146",authors:[{id:"39866",title:"Prof.",name:"Miriam",surname:"Jasiulionis",slug:"miriam-jasiulionis",fullName:"Miriam Jasiulionis"},{id:"297523",title:"Ms.",name:"Ana Luisa",surname:"Ayub",slug:"ana-luisa-ayub",fullName:"Ana Luisa Ayub"},{id:"297524",title:"Ms.",name:"Débora",surname:"Papaiz",slug:"debora-papaiz",fullName:"Débora Papaiz"},{id:"297527",title:"Dr.",name:"Roseli",surname:"Soares",slug:"roseli-soares",fullName:"Roseli Soares"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1723",title:"DNA 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Lately, sports medicine has grown from a special interest area in healthcare to an established profession in the medical career [1, 2].
Currently, sports medicine might be defined as the medical specialty concerned with the care and well-being of athletes and those engaged in physical activity, working as a health manager providing a comprehensive management plan to optimize health and performance for the athletes and to develop healthy lifestyles by counseling on physical activity and exercise within the healthcare system [1, 2, 3, 4].
The specialty as a primary care field encompasses many different disciplines and areas of expertise, such as internal medicine, family medicine, orthopedics, exercise science, cardiology, neurology, pediatrics, and emergency medicine. Sports medicine physicians, with their focus on sports and exercise medicine, are uniquely trained to provide such expertise to patients and medical colleagues [3, 5].
As consultants, they can be of great help in evaluating and treating active patients by efficiently connecting the different medical fields. Primary care sports medicine physicians can facilitate early diagnosis and management, thus accelerating recovery and avoiding long-term disability, providing adequate management, and eliminating the need for further consultation.
Patients can be seen quickly and cost-effectively. Therefore, sports doctors can reduce long waiting lists, solve the shortage of other specialists, and reduce the rising costs of healthcare. There is clearly an important role for the knowledge of sports medicine in the integral care of patients [1, 6].
However, the specialist physician in sports medicine is not always well understood by fellow doctors, health workers, team managers, and politicians. It is very challenging to change the current paradigms based on existing diseases in the health systems and the beliefs of the population, where the pharmaceutical industry has significant financial and political influence.
A consistent, sustained, and coordinated effort by the wider medical community, aligned with a bold political vision to change health systems and society’s culture to promote and support physical activity, is a crucial requirement.
As a general overview, medical students usually do not have many learning opportunities in sports medicine during regular medical programs. Previous publications evidenced that medical students would favor having more exposure to sports and exercise medicine and even suggest compulsory sports medicine education. Similarly, general practitioners feel inadequately trained to practice sports and exercise medicine [7, 8, 9, 10, 11].
Besides this hidden barrier, sports medicine is being more recognized as a potentially attractive career to be pursued by a growing number of young doctors all over the world. Sports and exercise medicine is a multidisciplinary specialty, which has the potential to provide a medical student with valuable learning opportunities at various stages of his/her training [1, 9, 12].
An increase in demand for sports medicine training would facilitate on understanding the specific field, its demands, and possible career pathways for the graduating physician. Program directors of the universities and medical schools should include sports and exercise medicine in their curricula and use the expertise of sports medicine physicians in their community. Lectures and clinical skill workshops on sports-related illness, injuries, and musculoskeletal examination should be included in the undergraduate years, complemented later by electives and rotations in sports medicine [7, 9].
The profession is moving firmly from the previous concept of “athlete’s medicine” toward a vision where the main concern of specialists is physical activity promotion. The current definition of sports and exercise medicine can be extended to public health, presenting greater impact on improving the overall health of the population and assisting the expansion of the specialty [1, 4, 12, 13, 14].
A high-quality structured education in the field of sports and exercise medicine should be the critical goal for practicing physicians. Primary care sports medicine fellowship programs are designed to provide comprehensive training in preventing and treating musculoskeletal and non-musculoskeletal conditions in athletes and active individuals [3].
The specific pathways and entrance criteria for the specialty might be slightly different depending on the country and medical boards. Although most of the programs have their organization and structure, there are no universal criteria established to describe benchmarks for quality improvement or standards of excellence. Every program has its specific strengths [5, 12, 15].
For instance, primary care sports medicine physicians in Canada and the United States follow a 1-year specialized fellowship training program. Practitioners can enter these programs via many routes, including other specialties, such as internal medicine, pediatrics, emergency medicine, physical medicine, and rehabilitation [3, 5].
On the other hand, New Zealand, Australia, and Brazil have similar training criteria, as do many European nations. In those countries, physicians can pursue the sports medicine residency as a 3–4-year program, immediately after graduating from medical school [5, 12, 15].
The sports medicine programs must provide specific areas of knowledge to properly qualify the sports medicine physician, as quality education should be the goal of all fellowship/residency programs. All sports medicine physicians must have comprehensive training in preventing and treating musculoskeletal and non-musculoskeletal conditions in athletes and active individuals [3, 5, 12].
Fellowships and residencies usually include training areas of internal medicine, pediatrics, clinical emergencies across the lifespan, rehabilitation, physiatry, orthopedics, exercise physiology, cardiology, pulmonology, rheumatology, and sports nutrition and practical training in events, clubs, specific sports, general exercise, and sports medicine care. Programs must also include theoretical education, including organizing/leading discussions, seminars, and clinical case reviews and attending lectures and medical ethics courses [3, 5, 12].
This section does not intend to determine the specific contents of the sports medicine programs. Its purpose is to demonstrate some of the core competencies of the sports medicine training and to provide additional information for the physician with interest in the specific field of practice [3, 5, 12].
The primary care sports and exercise medicine fellow/resident must be trained inpatient care to be able to diagnose and provide treatment of medical illnesses and injuries related to sports and exercise and proficiently perform all procedures essential to the practice of sports medicine. Medical development must include also biomedical, epidemiological, and social/behavioral sciences and its application to patient care [3, 5, 12].
The training doctor must be exposed to a different setting and clinical situations, with broad clinical experience, high patient load, and follow-ups, including different age groups, sports, genders, socioeconomic levels, types of sports, and levels of participation.
Fellows/residents should be exposed to event coverage in a variety of settings during their training year(s). These include covering youth or senior/professional sports teams; participating in elite-level Olympic sports, such as athletics, swimming, and gymnastics; and coverage of mass events, such as marathon or triathlon major events.
It is extremely important to participate in a variety of sports to become accustomed to the athletic environment and potential injuries that could be sustained during the events, possibly including coverage to contact sports to be exposed to concussion and other contact injuries.
Programs of excellence will have training doctors to perform pre-participation examinations for a variety of athletes and disciplines, including team sports, individual sports, elite, and young athletes.
Residents/fellows rotate with subspecialists; including sports cardiology; musculoskeletal radiology; rehabilitation; physical/occupational therapy; exercise physiology and performance; neurology; rheumatology; nutrition; psychology; orthopedic surgeons of shoulder, elbow, wrist/hand, hip, knee, and foot/ankle; and pediatric surgeons.
This provides exposure to acute fracture and dislocation management including assessment and diagnosis, splinting and casting.
These include training about the specific adaptations in the athlete’s heart, normal changes and pathological abnormalities. These perform and interpret the exams, provide proper care, and identify the need for continued investigations and referrals as needed.
Training on exercise prescription in the different population, their requirements, and specific needs.
Regarding this specific topic, there might be differences between programs and learning experiences, according to the country and expected field of work. In our understanding, these procedures are an integral component of most sports medicine practices and will be mentioned here.
Injections and other procedures to consider for general exposure include dry needling, autologous blood injections, platelet-rich plasma injections, and prolotherapy. Procedural training should include education in didactic theoretical and practical sessions, including mentored clinical experience and continuing education options to determine proficiency for all procedures.
Sports ultrasound might also be included in the training programs and is seen as an important skill to be performed. Current endorsements for recommended sports ultrasound curriculum for sports and exercise medicine physicians can be found in published journals and sports medicine associations [16].
Ability to work in a multidisciplinary team and to communicate efficiently are extremely important for the proper patient care not only in a team environment as a team doctor but also for best of care in the outpatient care directing proper multi-professional and teamwork for the patients.
The broad and specific knowledge of SEMP, when following a proper training program, allows him/her to provide comprehensive care of patients, being able to handle most of the illnesses and injuries, from the pre-participation assessment to the return-to-play decision.
The primary care sports medicine physicians can facilitate early diagnosis and management, thereby speeding recovery and preventing long-term disability. The appropriate case management, either with physiotherapy, bracing, and orthotics, injections, can optimize treatment pathways, eliminate the need for further consultation, and save time and healthcare costs.
The role of the specialist sports medicine physician is not always well-understood by medical colleagues, team managers, healthcare directors, and politicians. We here describe some of the characteristics of the sports doctor in the elite athlete care approach, event coverage, and healthy lifestyle promotion, including some interprofessional relationships needed in this field, which are usually different from regular working relations and organization found in the more traditional medical specialties.
The team physician’s education, training, and experience uniquely qualify to provide the best medical care for the athlete. Team physicians have the leadership role in the organization, management, and provision of care of athletes in individual, team, and mass participation sporting events.
The team physician should possess, be responsible for, and/or understand not only clinical illness and injuries, but also medical and administrative duties, ethical matters, medicolegal problems. This role must be developed to provide a foundation for best practices in the medical care of athletes and teams. The most important responsibility is the medical care of athletes at all ages and all levels of participation [17].
The team physician should be proficient in the prevention and care of musculoskeletal injuries and medical conditions encountered in sports. The team physician integrates medical expertise with medical consultants, strength and conditioning coaches, and other allied healthcare professionals. The team physician also is responsible for educating athletes, coaches, parents, and administrators. The team physician is ultimately responsible for the clearance to participate and the return-to-play decision [17, 18].
Expected requirements for the team physician are clinical training and experience including medical specialty board certification, residency/fellowship training in sports medicine, significant clinical practice focused on sports medicine, strong ethical values, proper management of confidentiality issues, informed consent, conflict of interest, influence of third parties, doping, drugs, sports products, and technology [17, 18].
The primary role of the sports medicine physician in competitive sports is the comprehensive health management of the athlete to optimize performance. Sports medicine physicians should focus on providing continuous clinical services with excellence, always in conjunct work with the coach and other members of the sports medicine and science team [13].
In this role, the sports medicine physician is involved in the rehabilitation of acute and chronic injuries as well as developing measures to reduce the risk of injury and illness occurrence or severity. To fulfill this role of comprehensive health management and athletes’ performance, the sports medicine physician must understand the demands and requirements of the athlete’s sports thoroughly.
An important part of elite sports physician role is the periodic health evaluation, which is the systematic evaluation of the health status of the athlete, seeking the best healthcare but also finding opportunities to optimize the athlete’s performance. These must be managed as a health assessment plan, based on initial assessments, follow-ups, and continued care, including cardiovascular screening, general health, clinical laboratory investigation (pertinent lab tests according to sports or discipline), and previous health information [13, 17, 18, 19].
The sports physician is the best person from medical staff to coordinate and manage a comprehensive illness and injury plan for elite athletes following that. The combination of excellence in clinical skills, sports-specific knowledge, and a thorough understanding of the athlete’s goal will make the sports medicine physician a trusted and respected member of the athlete support team.
The physician work environment might be different from the regular clinical office in the hospital as seen during the medical school. It might vary from a sports medicine institute to a training venue, sideline stretcher, or even a hotel room. It is important to be organized and to be able to record all medical information for proper medical care. Be fully aware that not always there will be a computer or a proper way to document the medical information. Improvisation is a key ability for the sports physician.
Therefore, appropriate clinical communication strategies will facilitate these situations. Multidisciplinary and integrated healthcare is a must for the elite athlete. Efficient and direct communication involving the athlete, coach, and members of the healthcare team are key elements to succeed in this environment [2, 20, 21].
In this perspective, another key point is to develop a clear risk decision-making strategy for the difficult situations involving the athlete’s health, specific clinical conditions (illness or injuries), competitions, and the athlete’s career. The role of the sports medicine physician is to present clear and precise information to the coach, pertinent staff, and athlete regarding the nature of the injury, possible interventions, the expected rehabilitation course and the timeframe to return to play, and, more importantly, the consequences of continuing to train or compete while injured [20, 21].
Having good relationships and proper understanding of the sports and integration within the team, the sports medicine physician can guide an appropriate path in these challenging circumstances. When working within clubs and organizations, it is ideal if the chief sports medicine physician and the head coach are also aligned with the performance team and the board of directors [2, 22].
Life-threatening emergency situations or conditions in which the athlete is not capable of taking decisions properly do not fit in this process. In these cases, the final decision must be clearly medical to guarantee the physical integrity and life of the athlete.
Besides, the role of sports medicine physicians in optimizing health and performance must be clearly defined and set apart from the malicious practice of doping in sports. It is a fundamental part of the job to educate the athletes, coaches, and managers about clean sports practice, the need for continued surveillance and health and career implications of doping medications and methods.
The sports medicine field demands effective collaboration between the respective disciplines and professions. It requires cooperation between different practitioners (physicians, physiotherapists, athletic trainers) to provide the care required by top-level performing athletes [2, 22].
The essential multidisciplinary nature of the field makes it difficult to define a medical specialty niche. There is a frequent overlapping nature of these professionals and disciplines, making difficult to define the identity of the sports physician. Thus, clear communication policies must be established and followed to avoid problematic issues between contribution and professional boundaries [2].
Unlike conventional health services, where physicians have a very visible professional status, in sports medicine, this status must be granted by relevant athletic experience. Also, some resistance to collaboration may come from a combination of doubt from a professional who comes from outside the sports networks established long ago in the team and an immediate assumption from the doctor that he or she will be effortlessly integrated into it [2].
While there are inevitably tensions surrounding traditional hierarchies, a system that encourages regular professional contact, as well as interprofessional learning opportunities, can gradually reverse these perceptions.
The team doctor role is based on clinical competencies, including pre-participation in health evaluations, integrated medical records, health and performance-focused risk decision-making, integration of communication, and implementation strategies within the specific sport. All of these are applied in a very close relation to the athlete, coach, and staff in a collaborative, balanced, evidence, and preference-based, individualized approach.
The sports medicine physician has an exclusive and important role in the major sports events, such as Olympic Games, Youth Olympic Games, The Fédération Internationale de Football Association (FIFA) World Cup, and world-level competitions. The unique know-how of the daily needs of the athletes, coaches, and specific disciplines or sports, in addition to the people management skills required by the daily sports medicine routine, makes the experienced sports medicine physician a key role in the successful organization and leadership of the major sports events.
The role includes organizing and planning medical care for players, team officials, event officials, and staff; doping control; management of healthcare issues; coordination with local organizing medical services; and injury assessment. The role requires exhaustive programming to preserve the athlete’s health and to optimize all collaborative work with individual sports governing bodies. It is part of the sports medicine physician responsibility to create plans for medical emergency responses, staff education, staff selection, background checks, medical equipment, and medication requirements for the specific event [13, 18, 23, 24].
Physical inactivity is a huge contributor to global health and a persistent public health problem associated with cardiovascular disease (CVD) and another noncommunicable disease. The World Health Organization ranks it as the fourth leading risk factor for overall morbidity and mortality worldwide [1, 25, 26, 27].
Inadequate physical activity is related to a considerable economic burden, and reports indicate that one third of the global population fails to meet physical activity (PA) guidelines and that 9% of the overall global premature mortality, 5.3 million deaths, is directly attributable to physical inactivity [4, 6, 25, 26, 27, 28].
As a result, there has been a significant growing global campaign on sports and exercise as key elements to address this pandemic by organizations such as the World Health Organization, International Olympic Committee, and Sports and Exercise Medical Societies promoting physical activity programs in the population [4, 6, 14, 25, 26, 27, 28, 29].
The health and economic burden related to the sedentary lifestyle urges the importance of combating physical inactivity. There is substantial evidence to support the benefits of exercise and the cost-effectiveness of exercise prescription in primary care [1, 6, 27, 30, 31, 32].
Sports medicine physicians play an important role in the dissemination of exercise recommendations to a great segment of the population. Due to the specialization in restoring function, combined with the background of team-based care in sports medicine, sports physicians are in a unique position to expand their scope of practice to use the expertise in promoting exercise in the community. It is the sports physician role to be proactive in counseling patients for prevention and treatment of such a sedentary lifestyle and its related diseases [1, 4].
Improving and maintaining recommended levels of physical activity lead to reductions in metabolic, hemodynamic, body composition, and risk factors that contribute strongly to the development of many of the major noncommunicable diseases. Therefore, exercise has a significant role, in many cases comparable or superior to drug interventions, in its prevention and management [1, 4, 30, 33].
Similarly, studies show that exercise interventions might be more effective than drug treatment among patients with stroke and as effective as medications for the prevention of diabetes and secondary treatment of cardiovascular disease. Physical activity can be as effective as medications for the treatment of depression and cognitive function in patients with Alzheimer disease [27].
Several high-level systematic reviews have also identified risk reductions of 25–50% or more in most major chronic diseases for individuals who achieve 150 min of moderate to vigorous physical activity per week. Although this target of 150 min may seem out of reach for many who are sedentary, studies have shown significant benefits for those who complete even small amounts of physical activity [27, 30, 34].
The sports and exercise medicine physician should have a key role in the promotion, integration, and facilitation of exercise as medicine within the healthcare system. Sports medicine physicians, with their focus on sports and exercise medicine, are uniquely trained to provide such expertise to patients, learners, and other physicians [1].
Helping patients to move from being sedentary to engaging in moderate levels of physical activity significantly reduces the risk of mortality. The medical specialist closest to the integration of exercise and health are sports and exercise medicine physicians, promoting comprehensive lifestyle interventions to patients for the prevention and management of chronic disease, along with expertise in the evaluation and management of medical conditions affecting activity and sports.
Evidence supporting the health benefits of physical activity is undeniable, and there is strong evidence that physicians can influence patients to significantly improve their health through proactive recommendations on the positive impacts of exercise on health during an office visit. Simple actions such as written exercise prescription, counseling and telephone support, or having the patient to wear a pedometer have a significant influence on engaging patients to be more active and healthy [1, 29, 35, 36, 37].
However, the sports medicine physician must be aware of barriers to overcome toward the healthy lifestyle promotion. These include the absence of structured systems to offer to counsel, including the limited staff, insufficient time to provide proper counseling services, and patient care primarily focused on acute care or problem-based care, rather than on preventive care or health promotion. Ameliorating population levels of physical activity require comprehensive efforts under a coordinated multilevel approach [1, 6, 26, 29].
Different strategies might be necessary to overcome the current barriers and provide efficient patient care as a general health manager. The sports physician must assess individual needs; address individual motivation, habits, preferences, and barriers; establish clear and realistic goals; promote behavioral change approaches; and establish follow-up, self-monitoring, and social support. Wearable technology and mobile apps for exercise monitoring might be also a very helpful strategy [33, 36].
Longitudinal follow-up is crucial to determine the patient’s progress, address specific problems, identify needs, and even adjust goals. Doctors should assess the physical activity level at each office visit. Also, establishing networks for exercise programs to standardize exercise interventions for different clinical subpopulations and to accommodate the continuum of primordial to tertiary prevention programs are very important. Studies have shown that physician counseling and exercise referral systems promote improvements in patients’ physical activity levels for up to 12 months.
Primary care sports medicine is a growing field in which the physician is trained exclusively to provide care throughout the continuum of injuries and illnesses, from acute assessment to return to sport, to managing complications and coexisting medical problems.
Sports medicine physicians are in a critical position to provide a comprehensive management plan to optimize athletes’ health and performance and to develop healthy lifestyles by advising them on physical activities and exercises in the health system.
The broad and specific knowledge provides comprehensive assistance to patients, being able to deal with most illnesses and injuries, from the pre-participation evaluation to the return-to-play decision. Sports physicians can facilitate early diagnosis and management of illness and injuries, accelerate recovery and avoid long-term disability, provide adequate management, and eliminate the need for further consultation.
The field of sports medicine requires effective collaboration between their respective disciplines and professions, whether as a team physician, event coordinator, or as a health manager promoting a healthy lifestyle.
Our business values are based on those any scientist applies to their research. The values of our business are based on the same ones that all good scientists apply to their research. We have created a culture of respect and collaboration within a relaxed, friendly, and progressive atmosphere, while maintaining academic rigour.
\n\nPlease check out our job board for open positions.
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Integrity - We are consistent and dependable, always striving for precision and accuracy in the true spirit of science.
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Among these, due to their unique physiochemical features, carbon-based materials, such as carbon nanotubes and graphenes, have received special attention in recent years, and examples of surface functionalization using various types of nanoparticles are presented. The future trends in sensor research activities and areas of development that are expected to have an impact in biosensor performance, like immobilization techniques, nanotechnology, miniaturization and multisensor array determinations, are also examined.",book:{id:"4624",slug:"biosensors-micro-and-nanoscale-applications",title:"Biosensors",fullTitle:"Biosensors - Micro and Nanoscale Applications"},signatures:"Robert Săndulescu, Mihaela Tertiş, Cecilia Cristea and Ede Bodoki",authors:[{id:"28983",title:"Prof.",name:"Robert",middleName:"Valentin",surname:"Sandulescu",slug:"robert-sandulescu",fullName:"Robert Sandulescu"}]}],mostDownloadedChaptersLast30Days:[{id:"72990",title:"Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics",slug:"nanoprecipitation-applications-for-entrapping-active-molecules-of-interest-in-pharmaceutics",totalDownloads:835,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixing-induced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the submicron and nanoscale levels. Thus, these particles could be intended among others, for developing innovative pharmaceutical products bearing advantages as controlled drug release, target therapeutic performance, or improved stability and organoleptic properties. On this basis, this chapter offers readers a comprehensive revision of the state of the art in research on carriers to be used for pharmaceutical applications and developed by the nanoprecipitation method. 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They form one of the most important classes of affinity biosensors based on the specific recognition of antigens by antibodies to form a stable complex, in a similar way to immunoassay. Depending on the type of transducer there are four types of immunosensor: electrochemical, optical, microgravimetric and thermometric. The most commonly used bioelements for the development of electrochemical immunosensors are antibodies (Ab), followed by aptamers (Apt) and, in the last five years, microRNA (miRNA). In order to perform an early diagnosis, a method that is able to measure peptides and proteins directly in a sample, without any sample pre-treatment or any separation, is preferred. This direct detection can be performed with methods making use of the specific interaction of proteins with Ab, Apt and miRNA. The recent developments made in the immunosensor field, regarding the incorporation of nanomaterials for increased sensitivity, multiplexing or microfluidic-based devices, may have potential for promising use in industry and clinical analysis. Some examples of assays for several commercially available biomarkers will be presented. The main application fields, beside biomedical analysis, are drug abuse control, food analysis and environmental analysis.",book:{id:"4624",slug:"biosensors-micro-and-nanoscale-applications",title:"Biosensors",fullTitle:"Biosensors - Micro and Nanoscale Applications"},signatures:"Cecilia Cristea, Anca Florea, Mihaela Tertiș and Robert Săndulescu",authors:[{id:"28983",title:"Prof.",name:"Robert",middleName:"Valentin",surname:"Sandulescu",slug:"robert-sandulescu",fullName:"Robert Sandulescu"}]},{id:"48575",title:"Impedimetric Sensors for Bacteria Detection",slug:"impedimetric-sensors-for-bacteria-detection",totalDownloads:3645,totalCrossrefCites:6,totalDimensionsCites:20,abstract:"The application of electrochemical biosensors based on impedance detection has grown during the past years due to their high sensitivity and rapid response, making this technique extremely useful to detect biological interactions with biosensor platforms. This chapter is focused on the use of electrochemical impedance spectroscopy (EIS) for bacterial detection in two ways. On one hand, bacteria presence may be determined by the detection of metabolites produced by bacterial growth involving the media conductivity changes. On the other hand, faster and more selective bacterial detection may be achieved by the immobilization of bacteria on a sensor surface using biorecognition elements (antibodies, antimicrobial peptides, aptamers, etc.) and registering changes produced in the charge transfer resistance (faradic process) or interfacial impedance (nonfaradic process). Here we discuss different types of impedimetric biosensors for microbiological applications, making stress on their most important parameters, such as detection limits, detection times, selectivity, and sensitivity. The aim of the paper was to give a critical review of recent publications in the field and mark the future trends.",book:{id:"4624",slug:"biosensors-micro-and-nanoscale-applications",title:"Biosensors",fullTitle:"Biosensors - Micro and Nanoscale Applications"},signatures:"Sergi Brosel-Oliu, Naroa Uria, Natalia Abramova and Andrey Bratov",authors:[{id:"174122",title:"Dr.",name:"Andrey",middleName:null,surname:"Bratov",slug:"andrey-bratov",fullName:"Andrey Bratov"},{id:"175939",title:"MSc.",name:"Sergi",middleName:null,surname:"Brosel-Oliu",slug:"sergi-brosel-oliu",fullName:"Sergi Brosel-Oliu"},{id:"175940",title:"Dr.",name:"Naroa",middleName:null,surname:"Uria",slug:"naroa-uria",fullName:"Naroa Uria"},{id:"175941",title:"Dr.",name:"Natalia",middleName:null,surname:"Abramova",slug:"natalia-abramova",fullName:"Natalia Abramova"}]},{id:"58296",title:"Recent Advances in Bioimaging for Cancer Research",slug:"recent-advances-in-bioimaging-for-cancer-research",totalDownloads:1420,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Molecular imaging techniques as well as nanoparticle applicable to molecular imaging are being explored to improve the cancer detection accuracy, which help to manage efficiently at the early stage. Among the various imaging technologies, optical imaging is a highly sensitive detection technique that allows direct observation of specific molecular events, biological pathways, and disease processes in real time through imaging probes that emit light in a range of wavelengths. Recently, nanoparticles have provided significant progresses that can be simultaneously used for cancer diagnosis and therapy (cancer theranostics). Theranostics aims to provide “image-guided cancer therapy,” by integrating therapeutic and imaging agents in a single platform. In addition, molecular imaging techniques facilitate “image-guided surgery” enabling maximization of tumor excision and minimization of side effects. The optical signals generated by fluorescence nanoparticles offer the possibility to distinguish tumor sites and normal tissues during surgery by real-time guidance, thereby increasing the long-term patient survival. These techniques will considerably contribute to reducing cancer recurrence and developing more effective cures. In this chapter, we will introduce diverse research on nanomaterials-based optical imaging for effective cancer therapy.",book:{id:"6398",slug:"state-of-the-art-in-nano-bioimaging",title:"State of the Art in Nano-bioimaging",fullTitle:"State of the Art in Nano-bioimaging"},signatures:"Jae-Woo Lim, Seong Uk Son and Eun-Kyung Lim",authors:[{id:"217456",title:"Dr.",name:"Eun-Kyung",middleName:null,surname:"Lim",slug:"eun-kyung-lim",fullName:"Eun-Kyung Lim"},{id:"226257",title:"Mr.",name:"Jae-Woo",middleName:null,surname:"Lim",slug:"jae-woo-lim",fullName:"Jae-Woo Lim"},{id:"226259",title:"Mr.",name:"Seong Uk",middleName:null,surname:"Son",slug:"seong-uk-son",fullName:"Seong Uk Son"}]}],onlineFirstChaptersFilter:{topicId:"205",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:10,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",slug:"abdelhamid-mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",slug:"ali-al-ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",slug:"carmelo-bastos-filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",slug:"efren-gorrostieta-hurtado",fullName:"Efren Gorrostieta Hurtado",profilePictureURL:"https://mts.intechopen.com/storage/users/38850/images/system/38850.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",slug:"yang-yi",fullName:"Yang Yi",profilePictureURL:"https://mts.intechopen.com/storage/users/239041/images/system/239041.jpeg",institutionString:"Virginia Tech",institution:{name:"Virginia Tech",institutionURL:null,country:{name:"United States of America"}}}]},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",slug:"asim-bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",slug:"joao-luis-garcia-rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. R.",surname:"Neves",slug:"antonio-neves",fullName:"Antonio Neves",profilePictureURL:"https://mts.intechopen.com/storage/users/1177/images/system/1177.jpg",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"220565",title:"Dr.",name:"Jucheng",middleName:null,surname:"Yang",slug:"jucheng-yang",fullName:"Jucheng Yang",profilePictureURL:"https://mts.intechopen.com/storage/users/220565/images/5988_n.jpg",institutionString:null,institution:{name:"Tianjin University of Technology",institutionURL:null,country:{name:"China"}}},{id:"29299",title:"Prof.",name:"Serestina",middleName:null,surname:"Viriri",slug:"serestina-viriri",fullName:"Serestina Viriri",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOalQAG/Profile_Picture_1620817405517",institutionString:null,institution:{name:"University of KwaZulu-Natal",institutionURL:null,country:{name:"South Africa"}}},{id:"315933",title:"Dr.",name:"Yalın",middleName:null,surname:"Baştanlar",slug:"yalin-bastanlar",fullName:"Yalın Baştanlar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002qpr7hQAA/Profile_Picture_1621430127547",institutionString:null,institution:{name:"Izmir Institute of Technology",institutionURL:null,country:{name:"Turkey"}}}]},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. 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