Amer Amal

The Ohio State UniversityUnited States of America

Dr. Amer is currently an Assistant Professor at The Ohio State University. She is a faculty in the Department of Microbial Infection and Immunity and the Department of Internal Medicine, Pulmonary Division. Dr. Amer is also a member in the Center for Microbial Interface Biology. Her MD and PhD training allowed her to contribute with her knowledge in several developing countries. She trained several undergraduate and graduate students as well as postdoctoral candidates and medical fellows from different parts of the world. Dr. Amer’s work is focused on the innate immune response to pulmonary pathogens such as Legionella pneumophila and Burkholderia cenocepacia. Legionella targets the elderly and immuno-compromised while Burkholderia targets patients with cystic fibrosis. Dr. Amer was among the first to establish the ligands for several NOD-like receptors and their role in inflammation. Dr. Amer also explored the role of autophagy as an innate immune response to Legionella and Burkholderia. Her recent work with Burkholderia offers new drug targets for the control of infection with Burkholderia which is resistant to most antibiotics. Dr. Amer’s long standing studies on the role of caspases during intracellular infection allowed the discovery of novel non-apoptotic functions of caspases.

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Latest work with IntechOpen by Amer Amal

Pulmonary infections are notorious in causing considerable morbidity and mortality. Caused by bacteria, viruses or fungi, respiratory infections require distinct knowledge of recent advances in pathogenesis. Progress in the understanding of immunopathogenesis of Acinetobacter baumannii infection will explain how an atypical organism establishes infection. The chapter regarding pulmonary nontuberculous mycobacterial infections in the State of Para depicts a unique study in an endemic region for tuberculosis in North of Brazil. The diagnosis and treatment of latent tuberculosis is a formidable challenge. Thus, new developments in diagnosis and treatment of latent tuberculosis are included in this book. Challenging in their diagnosis, nontuberculous mycobacterial pulmonary diseases require special education for management. The problems of respiratory infections in the immunocompromised host are increasing in numbers and in resilience to treatment. Therefore, the chapter describing the host immune responses against pulmonary fungal pathogens comes as a necessary section in this book. The insight brought forth from this book can be valuable for both clinicians and scientists.

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