Evolution in leukemia diagnosis.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"5254",leadTitle:null,fullTitle:"Real-time Systems",title:"Real-time Systems",subtitle:null,reviewType:"peer-reviewed",abstract:"This book is dedicated to Real-time Systems of broad applications, such as autonavigation (Kalman Filtering), real-time reconfiguration of distributed networks, real-time bilateral teleoperation control system over imperfect networks, and uniform interfaces for resource-sharing components in hierarchically scheduled real-time systems. In addition to that, wireless technology and its usage in implementing intelligent systems open a wide spectrum of real-time systems and offer great potential for improving people’s life: for example, wireless sensor networks used in subways, reduced energy consumption in public buildings, improved security through public surveillance, and high efficiency through industrial automation. Furthermore, electric utilities and multi-core CPU architecture, the driving force of modern life, are part of subjects benefited from the topics covered in this book.",isbn:"978-953-51-2397-2",printIsbn:"978-953-51-2398-9",pdfIsbn:"978-953-51-6654-2",doi:"10.5772/61695",price:119,priceEur:129,priceUsd:155,slug:"real-time-systems",numberOfPages:180,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"c2c891fef1bbc433b31b28863c5003af",bookSignature:"Kuodi Jian",publishedDate:"June 8th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5254.jpg",numberOfDownloads:14727,numberOfWosCitations:9,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:6,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:20,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 22nd 2015",dateEndSecondStepPublish:"November 12th 2015",dateEndThirdStepPublish:"February 16th 2016",dateEndFourthStepPublish:"May 16th 2016",dateEndFifthStepPublish:"June 15th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"107214",title:"Dr.",name:"Kuodi",middleName:null,surname:"Jian",slug:"kuodi-jian",fullName:"Kuodi Jian",profilePictureURL:"https://mts.intechopen.com/storage/users/107214/images/727_n.jpg",biography:"Dr. Kuodi Jian holds B.S. degree in Computer Science from the University of Mary Hardin-Baylor, and the M.S. degree in Computer Science and the Ph. D. degrees in Computer Science and Operations Research from the North Dakota State University. He worked as a Computer System Architect at the Banner Health System, Fargo, North Dakota. He is the Associate Professor (ICS Graduate Director) in Metropolitan State University since 2003. His research interests are in the areas of algorithms, programming languages, real-time operating systems, operations research, database systems, web service–oriented architecture (SOA), artificial intelligence, computer hardware, and computer simulation.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Metropolitan State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"753",title:"Operating System",slug:"electrical-and-electronic-engineering-operating-system"}],chapters:[{id:"50496",title:"Introductory Chapter: Real-Time Systems",doi:"10.5772/63443",slug:"introductory-chapter-real-time-systems",totalDownloads:2059,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Kuodi Jian",downloadPdfUrl:"/chapter/pdf-download/50496",previewPdfUrl:"/chapter/pdf-preview/50496",authors:[{id:"107214",title:"Dr.",name:"Kuodi",surname:"Jian",slug:"kuodi-jian",fullName:"Kuodi Jian"}],corrections:null},{id:"50636",title:"Real‐Time Reconfiguration of Distribution Network with Distributed Generation",doi:"10.5772/62632",slug:"real-time-reconfiguration-of-distribution-network-with-distributed-generation",totalDownloads:1920,totalCrossrefCites:2,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter shows a methodology to accomplish the real‐time reconfiguration of distribution networks considering distributed generation in normal operating conditions. The availability of the wind power generation, solar photovoltaic power generation, and hydroelectric power generation is considered in the reconfiguration procedure. The real‐time reconfiguration methodology is based on the branch‐exchange technique and assumes that only remote‐controlled switches are considered in the analysis. The multicriteria analysis, analytic hierarchy process (AHP) method, is used to determine the best switching sequence. The developed algorithms are integrated into a supervisory system, which allows real‐time communication with the network equipment. The methodology is verified in a real network of a power utility in Brazil with different typical daily demand curves and distributed generation scenarios.",signatures:"Daniel Bernardon, Ana Paula Carboni de Mello and Luciano\nPfitscher",downloadPdfUrl:"/chapter/pdf-download/50636",previewPdfUrl:"/chapter/pdf-preview/50636",authors:[{id:"180154",title:"Dr.",name:"Daniel",surname:"Bernardon",slug:"daniel-bernardon",fullName:"Daniel Bernardon"},{id:"181139",title:"MSc.",name:"Ana",surname:"Mello",slug:"ana-mello",fullName:"Ana Mello"},{id:"181140",title:"Dr.",name:"Luciano",surname:"Pfitscher",slug:"luciano-pfitscher",fullName:"Luciano Pfitscher"}],corrections:null},{id:"50400",title:"Uniform Interfaces for Resource-Sharing Components in Hierarchically Scheduled Real-Time Systems",doi:"10.5772/62691",slug:"uniform-interfaces-for-resource-sharing-components-in-hierarchically-scheduled-real-time-systems",totalDownloads:1498,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In literature, several hierarchical scheduling frameworks (HSFs) have been proposed for enabling resource sharing between components on a uni-processor system. Each HSF comes with its own set of composition rules which take into account a specific synchronization protocol for arbitrating access to resources. However, the inventors of these synchronization protocols have also chosen to describe these composition rules with the help of protocol-specific component interfaces. This creates unnecessary framework dependencies on components.",signatures:"Martijn M. H. P. van den Heuvel, Reinder J. Bril, Johan J. Lukkien, Moris Behnam and Thomas Nolte",downloadPdfUrl:"/chapter/pdf-download/50400",previewPdfUrl:"/chapter/pdf-preview/50400",authors:[{id:"116304",title:"Prof.",name:"Johan",surname:"Lukkien",slug:"johan-lukkien",fullName:"Johan Lukkien"},{id:"138504",title:"Dr.",name:"Reinder",surname:"Bril",slug:"reinder-bril",fullName:"Reinder Bril"},{id:"180341",title:"Dr.",name:"Martijn",surname:"Van Den Heuvel",slug:"martijn-van-den-heuvel",fullName:"Martijn Van Den Heuvel"},{id:"181808",title:"Dr.",name:"Moris",surname:"Behnam",slug:"moris-behnam",fullName:"Moris Behnam"},{id:"181809",title:"Prof.",name:"Thomas",surname:"Nolte",slug:"thomas-nolte",fullName:"Thomas Nolte"}],corrections:null},{id:"50459",title:"Real-Time Systems",doi:"10.5772/63278",slug:"real-time-systems",totalDownloads:1355,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Since 2004, most of chip vendors have begun to shift their major focus from single-core to multi-core architecture (W. Wolf. Signal Processing Magazine, IEEE, 26(6):50–54, 2009). One major reason of this shift is that it reaches a physical limit by scaling transistor size and increasing the clock frequency to improve the computing performance on a single-core architecture (Agarwal et al. Proceedings of the 27th International Symposium on, pages 248–259, June 2000), that is, the overall chip cannot be reached within a single clock cycle. Multi-core architecture, however, brings innovative and promising opportunities to further improve the computing performance. By providing multiple processing cores on a single chip, multi-core systems can dramatically increase the computing performance and mitigate the power and thermal issues with the same performance achievement as single-core systems. As multi-core architecture has been more and more dominant in the industrial market, there is an urgent demand for effective and efficient techniques for the design of multi-core systems.",signatures:"Ming Fan",downloadPdfUrl:"/chapter/pdf-download/50459",previewPdfUrl:"/chapter/pdf-preview/50459",authors:[{id:"180345",title:"Dr.",name:"Ming",surname:"Fan",slug:"ming-fan",fullName:"Ming Fan"}],corrections:null},{id:"50666",title:"Multi‐Objective Real‐Time Dispatching Problem in Electric Utilities: An Application to Emergency Service Routing",doi:"10.5772/62849",slug:"multi-objective-real-time-dispatching-problem-in-electric-utilities-an-application-to-emergency-serv",totalDownloads:1459,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter presents a novel application of real‐time dispatching problem to electric utilities when multi‐objective is involved. It is described how the problem related to emergency services in electric utilities is considered, with an aggregated objective function developed to handle the minimization of the waiting time, the total distance traveled, the sum of all delays related to already assigned orders, and the cost of non‐assigned emergency orders. After that, actual cases have shown the effectiveness of the proposed model to be adopted in real‐world applications either as a search for optimal solution or by applying a heuristic‐based algorithm developed.",signatures:"Vinícius Jacques Garcia, Daniel Bernardon, Iochane Guimarães and Júlio Fonini",downloadPdfUrl:"/chapter/pdf-download/50666",previewPdfUrl:"/chapter/pdf-preview/50666",authors:[{id:"110560",title:"Dr.",name:"Daniel",surname:"Bernardon",slug:"daniel-bernardon",fullName:"Daniel Bernardon"},{id:"180657",title:"Dr.",name:"Vinicius Jacques",surname:"Garcia",slug:"vinicius-jacques-garcia",fullName:"Vinicius Jacques Garcia"},{id:"185491",title:"BSc.",name:"Iochane",surname:"Guimarães",slug:"iochane-guimaraes",fullName:"Iochane Guimarães"},{id:"185492",title:"BSc.",name:"Júlio",surname:"Fonini",slug:"julio-fonini",fullName:"Júlio Fonini"}],corrections:null},{id:"50419",title:"Kalman Filtering and Its Real‐Time Applications",doi:"10.5772/62352",slug:"kalman-filtering-and-its-real-time-applications",totalDownloads:3176,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Kalman filter was pioneered by Rudolf Emil Kalman in 1960, originally designed and developed to solve the navigation problem in Apollo Project. Since then, numerous applications were developed with the implementation of Kalman filter, such as applications in the fields of navigation and computer vision's object tracking. Kalman filter consists of two separate processes, namely the prediction process and the measurement process, which work in a recursive manner. Both processes are modeled by groups of equations in the state space model to achieve optimal estimation outputs. Prior knowledge on the state space model is needed, and it differs between different systems. In this chapter, the authors outlined and explained the fundamental Kalman filtering model in real‐time discrete form and devised two real‐time applications that implemented Kalman filter. The first application involved using vision camera to perform real‐time image processing for vehicle tracking, whereas the second application discussed the real‐time Global Positioning System (GPS)‐aided Strapdown Inertial Navigation Unit (SINU) system implementation using Kalman filter. Detail descriptions, model derivations, and results are outlined in both applications.",signatures:"Lim Chot Hun, Ong Lee Yeng, Lim Tien Sze and Koo Voon Chet",downloadPdfUrl:"/chapter/pdf-download/50419",previewPdfUrl:"/chapter/pdf-preview/50419",authors:[{id:"162863",title:"Dr.",name:"Lim",surname:"Chot Hun",slug:"lim-chot-hun",fullName:"Lim Chot Hun"},{id:"162864",title:"Dr.",name:"Lim",surname:"Tien Sze",slug:"lim-tien-sze",fullName:"Lim Tien Sze"},{id:"162865",title:"Prof.",name:"Koo",surname:"Voon Chet",slug:"koo-voon-chet",fullName:"Koo Voon Chet"},{id:"181409",title:"Ms.",name:"Lee Yeng",surname:"Ong",slug:"lee-yeng-ong",fullName:"Lee Yeng Ong"}],corrections:null},{id:"50530",title:"A Real-Time Bilateral Teleoperation Control System over Imperfect Network",doi:"10.5772/63033",slug:"a-real-time-bilateral-teleoperation-control-system-over-imperfect-network",totalDownloads:1550,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Functionality and performance of modern machines are directly affected by the implementation of real-time control systems. Especially in networked teleoperation applications, force feedback control and networked control are two of the most important factors, which determine the performance of the whole system. In force feedback control, generally it is necessary but difficult and expensive to attach sensors (force/torque/pressure sensors) to detect the environment information in order to drive properly the feedback force. In networked control, there always exist inevitable random time-varying delays and packet dropouts, which may degrade the system performance and, even worse, cause the system instability. Therefore in this chapter, a study on a real-time bilateral teleoperation control system (BTCS) over an imperfect network is discussed. First, current technologies for teleoperation as well as BTCSs are briefly reviewed. Second, an advanced concept for designing a bilateral teleoperation networked control (BTNCS) system is proposed, and the working principle is clearly explained. Third, an approach to develop a force-sensorless feedback control (FSFC) is proposed to simplify the sensor requirement in designing the BTNCS, while the correct sense of interaction between the slave and the environment can be ensured. Fourth, a robust-adaptive networked control (RANC)-based master controller is introduced to deal with control of the slave over the network containing both time delays and information loss. Case studies are carried out to evaluate the applicability of the suggested methodology.",signatures:"Truong Quang Dinh, Jong Il Yoon, Cheolkeun Ha and James\nMarco",downloadPdfUrl:"/chapter/pdf-download/50530",previewPdfUrl:"/chapter/pdf-preview/50530",authors:[{id:"168437",title:"Prof.",name:"Cheolkeun",surname:"Ha",slug:"cheolkeun-ha",fullName:"Cheolkeun Ha"},{id:"181747",title:"Dr.",name:"Truong Quang",surname:"Dinh",slug:"truong-quang-dinh",fullName:"Truong Quang Dinh"},{id:"185978",title:"Dr.",name:"Jong Il",surname:"Yoon",slug:"jong-il-yoon",fullName:"Jong Il Yoon"},{id:"185979",title:"Prof.",name:"James",surname:"Marco",slug:"james-marco",fullName:"James Marco"}],corrections:null},{id:"50267",title:"Wireless Real-Time Monitoring System for the Implementation of Intelligent Control in Subways",doi:"10.5772/62679",slug:"wireless-real-time-monitoring-system-for-the-implementation-of-intelligent-control-in-subways",totalDownloads:1711,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter looks into the technical features of state-of-the-art wireless sensors networks for environmental monitoring. Technology advances in low-power and wireless devices have made the deployment of those networks more and more affordable. In addition, wireless sensor networks have become more flexible and adaptable to a wide range of situations. Hence, a framework for their correct implementation will be provided. Then, one specific application about real-time environmental monitoring in support of a model-based predictive control system installed in a metro station will be described. In these applications, filtering, resampling, and post-processing functions must be developed, in order to convert raw data into a dataset arranged in the right format, so that it can inform the algorithms of the control system about the current state of the domain under control. Finally, the whole architecture of the model-based predictive control and its final performances will be reported.",signatures:"Alessandro Carbonari, Massimo Vaccarini, Mikko Valta and\nMaddalena Nurchis",downloadPdfUrl:"/chapter/pdf-download/50267",previewPdfUrl:"/chapter/pdf-preview/50267",authors:[{id:"10486",title:"Dr.",name:"Alessandro",surname:"Carbonari",slug:"alessandro-carbonari",fullName:"Alessandro Carbonari"},{id:"150738",title:"Dr.",name:"Massimo",surname:"Vaccarini",slug:"massimo-vaccarini",fullName:"Massimo Vaccarini"},{id:"185509",title:"Dr.",name:"Mikko",surname:"Valta",slug:"mikko-valta",fullName:"Mikko Valta"},{id:"185510",title:"Dr.",name:"Maddalena",surname:"Nurchis",slug:"maddalena-nurchis",fullName:"Maddalena Nurchis"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5438",title:"Operations Research",subtitle:"the Art of Making Good Decisions",isOpenForSubmission:!1,hash:"788338a326fcfe39265211c29138ba7a",slug:"operations-research-the-art-of-making-good-decisions",bookSignature:"Kuodi Jian",coverURL:"https://cdn.intechopen.com/books/images_new/5438.jpg",editedByType:"Edited by",editors:[{id:"107214",title:"Dr.",name:"Kuodi",surname:"Jian",slug:"kuodi-jian",fullName:"Kuodi Jian"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"75279",title:"Introductory Chapter: A Brief History of Acute Leukemias Treatment",doi:"10.5772/intechopen.96439",slug:"introductory-chapter-a-brief-history-of-acute-leukemias-treatment",body:'
The first case of leukemia had been probably described by Velpeau in 1827 [1]. Literally, he described his patient as ‘
1600 BC | First written description of cancer in ancient Egypt |
1670* | Examination of the blood with the compound microscope |
1827 | First clinical description of leukemia by |
1847 | Term “leukemia” coined by |
1872 | |
1877 | |
1913 | Distinction of acute and chronic, lymphoid and myeloid leukemias |
1914 | |
1974 | FAB classification of leukemias based on cytology |
2008 | WHO classification of leukemia including molecular subtypes |
Evolution in leukemia diagnosis.
In 1930, Dr. Gloor from the Naegeli’s clinic in Zurich [3], described “
In 1948, based on the evidence that AL children receiving folic acid did worsen, Dr. Farber proposed the first rational treatment for AL [2, 5]. He correctly guessed that blocking folic acid metabolism could on the contrary avoid leukemic cells growth. Based on that, he wrote “we may now with some justice hope that aminopterin, or some as yet unsynthesized substance related to it, will afford a substantial basis for real hope in this now hopeless disease” [5].
Despite Farber intuition, the prognosis of AL patients remained very poor throughout the 1950s and the 1960s. When Boggs, Wintrobe, and Cartwright examined the overall outcome of AL patients treated with 6- mercaptopurine (6-MP) and methotrexate, they were discouraged, and concluded that, “
Conversely, in the pediatric setting, progressive and impressive improvements were seen starting in the 1960s, especially due to the big efforts of Don Pinkel and Colleagues at St. Jude Institute [7, 8]. Particularly, they systematically changed and improved their chemotherapy regimens, documenting a terrific improvement in a few decades in the prognosis of children affected by AL, an almost invariably fatal disease till then [7, 8].
By contrast, the prognosis remained dismal in adults. However, largely following pediatric studies, the treatment of lymphoid (ALL) and non-lymphoid (myeloid, AML) leukemias became progressively distinct. Eventually, in 1973, the combination of daunorubicin and cytarabine, administered according to the 3 + 7 scheme was documented to be effective in acute myeloid leukemia [9], while post-induction intensification was further developed for ALL (see a schematic timeline of anti-leukemia treatments development in Table 2).
1865 | |
1895 | Radiation therapy was administered with transient benefit |
1930 | |
1943 | Isolation of folic acid |
1948 | Nitrogen mustard for Hodgkin disease; Antifols: aminopterin then amethopterin (methotrexate) for acute lymphoblastic leukemia |
1951 | Adrenocorticotropic hormone then prednisone for acute lymphoblastic leukemia |
1953 | Mercaptopurine, methotrexate licensed by the FDA |
1955 | Prednisone licensed by FDA |
1958 | Dexamethasone licensed by FDA |
1958 | Cyclophosphamide licensed by FDA |
1963 | Vincristine licensed by FDA |
1969 | Cytarabine licensed by FDA |
1978 | Native L-asparaginase licensed by FDA |
1979 | Daunorubicin licensed by FDA |
1983 | Etoposide licensed by FDA |
1987 | Mitoxantrone licensed by FDA |
1994 | Pegylated L-asparaginase licensed by FDA |
1995 | All-trans-retinoic acid approved for acute promyelocytic leukemia |
2000 | Arsenic trioxide licensed for acute promyelocytic leukemia by FDA |
2001 | Imatinib licensed for chronic myelogenous leukemia by FDA* |
Development of anti-leukemia treatments (adapted from Paul S. Gaynon, Toska J. Zomorodian, and Donald Pinkel. History of leukemia: Historical perspectives. In childhood Leukemias: Third edition, by Ching-hon Pui, Ed. Cambridge university press 978–0–521-19661-1).
During XXI century, several novel targeted agents were then approved.
In the 1950s, pre-clinical experiments led to the evidences that bone marrow engraftment after sub-lethal irradiation was associated to leukemia disappearance in mice [10]. This prompted further clinical research in humans and in 1957 Donald Thomas described the first intravenous infusion of bone marrow in humans [11]. In the following decades, tremendous progresses were made and successful bone marrow transplantations were recorded in acute leukemia patients, wither with relapsed/refractory disease and in complete remission [12, 13, 14]. By time, bone marrow transplantation evolved to stem cell transplantation, with different sources being available such as marrow, peripheral blood, and umbilical cord blood. At the same time, donation was not limited to siblings but extended to voluntary matched donors, the first registry being funded in UK in 1974, and even only partially compatible ones, in the so called haploidentical transplant (Table 3).
1873 | Blood transfusion first applied to leukemic patients ( |
1901 | First description of human blood groups ( |
1937 | First hospital blood bank |
1954 | Introduction of platelet transfusion |
1957 | First successful syngeneic bone marrow transplantation |
1968 | First successful sibling donor bone marrow transplant (immunodeficiency) |
1972 | First successful matched sibling donor marrow transplantation (aplastic anemia) |
1974 | Anthony Nolan Bone Marrow Donor Registry (UK) |
1977 | Evidence of survivals >1 for 18/110 patients with advanced leukemia transplanted from matched donors |
1979 | Report of Success >50% for matched sibling donor marrow transplantation for acute myeloid leukemia in first remission |
1986 | National Marrow Donor Registry Program (USA) |
1983 | First successful haploidentical T-cell depleted bone marrow transplant |
1989 | First successful transplant using umbilical cord blood |
1997 | First reduced-intensity bone marrow transplantation |
2002 | First generation CAR-T cells |
2017 | The FDA approves CD19-directed CAR T cells for the treatment of relapsed, refractory acute lymphoblastic leukemia in children and young adults. |
Evolution of transfusion services and stem cell transplantation.
Overall, however, the success of anti-leukemic treatments was achieved not only by developing new drugs and schemes (Table 2) [15] but also by dramatically improving supportive cares (Table 3) [15], especially as far as blood and derivates transfusion as well as anti-microbe drugs were concerned. Particularly, after the first blood transfusion in a leukemic patient in 1873, the most significant advancement was represented by blood groups description in 1901 by Landsteiner et al. Eventually, in 1937 the first hospital blood bank was established and blood products such as platelets were successfully administered in 1954 [15].
The most recent advances, spanned across the last 3 decades, can be largely attributed to a terrific improvement in technology and a definitely better knowledge of leukemia biology (Table 4) [15]. Specifically, after the first recognition of recurrent genomic imbalances in the 1970s, patients’ risk of recurrence, and therefore the most appropriate treatment (more or less intensified), were defined by cytogenetic analyses [16, 17]. Subsequently, quantitative polymerase chain reaction (PCR) based techniques allowed an accurate and reliable quantitation of the residual disease, this becoming a major factor in determining the choice of treatment (more or less intensified chemotherapy, stem cell transplantation, and targeted drugs) especially in ALL [18]. Finally, next generation sequencing, the first AML genome studied in 2008 [19], quickly led to a refined molecular classification of both AML and ALL [20, 21], unveiling new therapeutic targets and hopefully nearing the new era of personalized medicine. Indeed, in the current century, a series of amazing new drugs have been licensed for acute leukemia treatment, including tyrosine kinase inhibitors, BCL2 inhibitors, IDH2 inhibitors, demethylating agents, and monoclonal antibodies including the novel bispecific T-cell engagers (Table 3). On the other hand, the latest frontier of cellular therapy relies on the chimeric antigen receptor T-cell therapies (CAR-T), firstly demonstrated to be effective in younger ALL patients [22].
1670* | Examination of the blood with the compound microscope |
1877 | |
1934 | Flow cytometry |
1960* | Metaphase cytogenetics; |
1975 | Production of monoclonal antibodies |
1978 | Thiopurine methyltransferase polymorphisms related to response and toxicity |
1980 | Fluorescent in situ hybridization |
1985 | Polymerase chain reaction |
1996 | Gene expression arrays |
1998 | Minimal residual disease by the polymerase chain reaction |
2001 | Classification of AML risk based on cytogenetic features |
2008 | First whole genome sequencing in AML |
2016 | Genomic Classification and Prognosis in Acute Myeloid Leukemia |
2017 | Integration of Next-Generation Sequencing to Treat Acute Lymphoblastic Leukemia |
Evolution of technologies that re-defined leukemia diagnosis and prognostication.
Approximately.
We may certainly expect that further improvements in our understanding of leukemogenesis will lead to later significant success in curing these still terrible diseases.
A goat-centered approach to farming can help shift rural agrarian households and communities toward gender-inclusive climate change adaptation in agriculture to enhance food security and nutrition in sub-Saharan Africa. Goat rearing is a potential sustainable and holistic approach to addressing the triple challenges of gender inequality, climate change, and food insecurity in rural communities of this region. These challenges are deeply intertwined and are among the most defining socioeconomic and environmental concerns in rural communities’ livelihoods. Since these challenges are interdependent, it is imperative to develop a sustainable holistic approach that integrates economic, social, and environmental variables to address them.
This chapter discusses the potential of goat farming as a sustainable and holistic approach to addressing the aforementioned challenges. Agriculture (crop and livestock) is a key livelihood activity, but it is vulnerable to climate change [1]. In recent decades, global awareness of the need to adapt agricultural systems and rural resource-poor livelihoods to the stressors emanating from climate change and variability has intensified [2]. In addition, gender, as a socioeconomic–cultural factor, has been applied to assess the roles, responsibilities, constraints, opportunities, and incentives of people involved in agriculture [3, 4]. Similarly, the awareness of integrating gender aspects into climate change action in the agricultural sector to enhance food security has been recognized. The disregard of gender-specific differences in adaptive and mitigative capacity allows climate change to worsen the existing gender inequalities in agriculture and beyond [5].
The question in this context is “How do goats fit into this matrix?” The frame of reference is that goat rearing is an integral component of a climate-smart livestock production strategy, acting also an entry point for gender equality [6]. The multifactorial role of goat “power” in sub-Saharan Africa first acts as an entry point for gender equality [7] and second as an agroecological zone-specific, climate-resilient, thermotolerant animal species that can sustain productivity [8] and enhance food and nutrition security. The inherent small size of goats is beneficial for socioeconomic, managerial, biological, survival, productivity, and food security reasons [9].
Goats in rural areas have been deeply embedded in the socioeconomic and environmental fabric as a major livestock species that is rapidly increasing in number and is unlikely to change significantly in the foreseeable future [9, 10]. The unquestionable potential of smallholder livestock systems to sustain livelihood to billions of rural food producers and reduce vulnerabilities in rural resource-poor economies [11] renders goats an attractive option for pro-poor agricultural development agendas and enhancement of food and nutrition security. The diverse range of agroecological zones and management systems in sub-Saharan Africa where goats are reared despite the harsh environmental conditions is a testimony to their adaptability, and the assumption is that they will preserve their productivity and thus enhance the food and nutrition situation in rural areas. Most goats are kept in rural resource-poor agricultural systems, and their relative distribution is immense because of their comparative adaptive advantages over other animal species in most agroecological zones in sub-Saharan Africa. These systems, because of climate change, are never static but are constantly evolving with changing internal and external factors. Despite this, goats have continued to play a significant role in the food chain and overall livelihoods of rural households, which are largely the property of women and their children.
The inherent proficiency to rear, reproduce, and produce goats in adverse climate conditions is ascribable to their adaptive traits, as they proffer multiple products and services and benefit rural economies greatly [12]. This chapter presents an overview of the potential of goat rearing as a sustainable and holistic approach to addressing the triple challenges of gender inequality, climate change, and food insecurity in rural communities of Sub-Saharan Africa.
For this study, we conducted research using scientific papers, books, and statistical data from the United Nations to examine the interconnectedness of goat production, gender, climate change, and food security in rural economies in sub-Saharan Africa. The concept is based on the realization that the multifactorial role of goat “power” in this region acts as an entry point for gender equality and that goats are an agroecological zone-specific, climate-resilient, thermotolerant animal species capable of sustaining productivity and enhancing food and nutrition security in resource-poor rural areas.
In 2019, the estimated population of sub-Saharan Africa was 1.1 billion [13]. This number is expected to increase to 2–2.5 billion by 2050, which will drive the population density to 80 people per square km. It should be noted that the larger proportion of the population in the region dwells in rural areas and is mainly dependent on agriculture. Therefore, it is reasonable to assume that there will be more people to feed and thus there will be more pressure on natural resources. As such, there is a need to strategize a plan for enhancing food and nutrition security. According to [14], the projection in the Sub-Saharan African population increment is that it will double by 2050. The increase in the sub-Saharan population and the need to provide food for a growing population, compounded by novel consumption patterns, will put a burden on livestock production systems and products [15, 16, 17]. This scenario is more compelling due to the advent of climate change, which obviously reduces agricultural production in general, especially in rural areas. As shown in Figure 1, it has been projected that sub-Saharan Africa will outpace other regions in population growth. Figure 2 illustrates that the doubling of the human population as projected will likely pose a greater challenge to the rural population, as it makes up the greater proportion of the population in sub-Saharan Africa [14]. Similarly, Figure 3 shows that population growth in rural areas outpaces that of urban dwellers in developing countries because of pressure on natural resources.
Evolution of the world human population between 1950 and 2100 [
Human population in sub-Saharan Africa (2000–2030) [
Urban and rural populations in developing countries, 1960–2030 [
Livestock systems, as agricultural subsectors, are the major users of natural resources, which has a bearing on the relationship between agricultural production and resource use efficiency. Therefore, strengthening the role of livestock in rural areas is deemed a noble cause of sustaining the sub-Saharan rural food economies. In this respect, the socioeconomic and environmental merits of livestock systems and how they contribute significantly to the livelihoods of at least 1.3 billion people in rural areas have been the focus of substantial public debate [10, 21]. Figure 4 illustrates the increasing disparity between population growth and food production in sub-Saharan Africa.
Trends in human population growth and food production in sub-Saharan Africa [
Unless constraints on greater agricultural productivity are addressed, one-third of the population in this region will not have sufficient food by 2050. This indicates that regional poverty (Figure 5) and undernutrition (Figure 6) are rife in sub-Saharan Africa.
Regional poverty [
Nutrition status in sub-Saharan Africa [
Figure 7 shows that the goat population worldwide increased steadily between 1994 and 2014. Figure 8 illustrates the wider proliferation of goats in all the key agroecological zones of sub-Saharan Africa. In terms of world production, the share of goats produced by continental Africa is the second largest after Asia. This is an indication of the value of promoting goat production on the continent. Africa’s goat population increased by 75% between 1980 and 2005 and constitutes 30% of the world goat population immensely contributed to the livelihoods of millions of rural economies [27]. [28] approximated that the tropics and subtropics are home to 94% of the world’s goat population. The reported livestock population of sub-Saharan Africa in 1999 comprised 182.1 million goats, [29] with approximately 64% located in rural arid (38%) and semiarid (26%) agroecological zones; more than 90% of goats in these zones are indigenous.
Goat world population trends, 1994–2014 [
African livestock and their agroecological zone in sub-Saharan Africa [
Despite these healthy statistics, sub-Saharan Africa has the second largest number of poor livestock farmers in the world. Poverty is rife on the continent (Figure 5), as are food insecurity and malnutrition (Figure 6). In sub-Saharan Africa, a greater proportion of the population remains undernourished, whereas Asia, the world’s most populous continent, has a hunger ranking, as it is home to more than 526 million people [18]. Climate variability and extreme weather events are among the key drivers of the recent increase in global hunger and some of the leading causes of other socioeconomic and environmental challenges.
Figure 8 shows the adaptive potential of goats, which is clarified by the diverse.
worldwide proliferation across all key agroecological zones of sub-Saharan Africa from the tropical highlands to the humid regions and environmental interface.
Figure 9 shows that Africa is home to 33.1% of the world’s goat population, and a greater proportion of livestock are reared by poor farmers (Figure 10). Goats in Africa account for approximately 36% of the total world population of grazing animals and are vital for the development of rain-fed, less-favored areas [7]. These systems, due to the effects of climate change, are never static but are constantly evolving with changing internal and external climatic factors.
Production of share of goats by continent [
Number of poor livestock farmers [
The poor resource farmers in sub-Saharan Africa are highly vulnerable to climatic and environmental hazards, as their choices for resource diversification are limited. In some cases, vulnerability due to climate change has worsened due to disparities in engendered climate change impacts and response knowledge in agriculture. This solicit for clear response strategies from the point of view of mitigation and adaptation to address the threats posed by climate change.
In this regard, the proposition of goat-centered mitigation and adaptation strategies that take into account gender relations but also curtailed the adverse effects of climate change variability and food security is called for.
Agriculture is the backbone of rural economies in sub-Saharan Africa and makes a significant contribution to households’ food and nutrition security. However, despite agriculture sustaining livelihoods in rural, resource-poor farming sectors, it is one of the most climate-sensitive activities. Hence, it is imperative that mechanisms are put in place that protect the agriculture sector from the adverse impacts of climate change. At the same time, agriculture must mitigate its contributions to climate change (13.5 percent of global greenhouse gas (GHG) emissions come from agricultural activity) [31]. As a result, mitigation strategies that are not only effective but also sustainable are needed. It is clear now that climate variability and change impact both crop and livestock productivity as well as people’s livelihoods [32]. The influence of adverse effects of climate variability and change on rural agrarian households are anticipated to worsen in the future. The provision of coping strategies at agrarian households in addition to formulating appropriate agricultural-related policies will minimize these adverse effects.
Climate change is debatably one of the key challenges affecting sub-Saharan African countries, primarily because of the region’s greater reliance on climate-sensitive sectors such as agriculture and inability to adapt to the changing climate [33]. Thus, there is a growing interest in devising strategies to cope with climate change effects on agricultural systems to avoid compromising agricultural productivity and enhance food security. In this context, we propose that goat production is a potential strategy to mitigate climate change effects in rural economies in sub-Saharan Africa. The practicability of this undertaking is based on the fact that the socioeconomic role of goat rearing has expanded during the last decades, especially in developing countries that are routinely exposed to adverse environmental conditions [34]. In addition, goats are an integral part of resource-poor animal production systems because of their short gestation period, high prolificacy, rapid growth rate, high feed conversion efficiency, high disease resistance capacity, and easy marketability.
The impact of climate change on goat production can be assessed by considering the direct or indirect effects of climate change on agriculture and food security. The direct consequences of climate change on agricultural systems and food security incorporate goats’ structural, functional, and feeding behavior and their interaction with environmental conditions, as well as issues such as the optimal use of feeding resources, which is one of the major components that has been greatly affected by climate change. The elevation in ambient temperatures across continents due to climate change increases the vulnerability of rural agrarian households and communities due to perennial drought and food and nutrition insecurity. Figure 11 shows the world average temperature variation from 1850 to 1900, and Figure 12 illustrates the mean temperature increment for the past 100 years in Africa. The trends provide evidence of the reality of climate change, which in turn has a bearing on agricultural production.
Global mean temperatures 1850–1900 [
Mean temperature anomalies in Africa (source UNEP, 2002).
Similarly, climate change’s distortion of rainfall patterns consistently poses a threat to food and nutrition. It is common knowledge that rising temperatures and changes in rainfall patterns have a direct effect on agricultural productivity and food and nutrition security. However, the influence of these factors differs among various animal species, not to mention annual and perennial crops and agroecological regions of the world. Goat rearing as a sustainable and holistic approach to mitigating climate change and gender inequality is based on the notion that goats are relatively adaptable to the harshest agroecological regions and have the advantage of numbers. The largest share of goats is reared in rural agrarian systems, and their numerical distribution is vast because of their comparative advantages over other animal species in most agroecological zones in sub-Saharan Africa.
Climate change and variability are detrimental to general livestock production because they negatively affect the quality of feed crops and forage, water availability, animal and milk production, animal reproduction, and biodiversity, as well as lead to livestock diseases and parasites [36]. Despite all this, goats have emerged as an animal species of choice because of their ability to adapt to extreme and harsh climatic, geographical, and environmental conditions [37, 38]. Horst noted that goats have exceptional capacity to recover from drought because of their efficient reproductive behavior and variable body size [39].
One of the adverse effects of climate change on livestock rearing is grazing quality and quantity [40]. Under most rangelands where goats survive, forage has diminished over the years due to adverse climatic effects; therefore, the feeding behavior of animals has become critical. In this case, ruminants’ energy requirements and digestive efficiency are vital criteria for selecting the most appropriate animal to rear in particular circumstances [41]. Aziz [42] observed that goats survive in differing ecological conditions, subsisting on different nutritional regimes under which they evolved and consequently sustaining their productivity. Principally, goat feeding behavior is intermediate and fixed, which favors both grazing and browsing, utilizing grasses in addition to shrubs [43]. In this venture, goats are extremely useful and effective in combating undesirable bush encroachment [44], which may be a dominant feature in most rural and poor communities.
Indigenous small stocks, such as goats, are much better adapted to local conditions than exotic stocks and require far fewer inputs for survival [45]. Of significance, goats have a greater capacity than other farm-reared ruminants to efficaciously convert poor feed resources into animal products such as milk and meat. The inherent complexity of goat structural, functional, and feeding behavior advantages has helped goat production under climate change-induced extreme environmental conditions. Principally, the structural, functional, and feeding behaviors of goats play a critical role in enhancing production, reproduction, and survival in adverse conditions.
Multiple environmental stressors are a frequent occurrence in most rural agriculture systems in sub-Saharan Africa and will presumably increase due to climate change variability, which may depress agricultural productivity and food security [9]. In the ranks of climatic change stressors, heat stress emerges as the primary component that adversely influences livestock production. In this regard, goat rearing becomes vital to sustain livestock production and enhance food security. This does not coincide with the proliferation of approximately 41.5% of the goat population existing in harsh semiarid/arid areas in tandem with the continued syndrome of poverty adaptation-fragile livelihoods [7], which explains the ability of goats to sustain their production under climate change-induced extreme environmental conditions.
The concentration of goat populations in the harsh tropical and subtropical agroecological regions of the world demonstrates that they are more heat tolerant than other ruminant animal species [46]. In most cases, black goats are prone to minimizing energy disbursement in winter; nevertheless, they experience a greater solar heat load in hot conditions. Therefore, there is a need for breeding lighter coats in goats, as ambient conditions might progressively become hotter and drier because of climate change variability.
Goats, through alterations in behavioral, morphological, or physiological responses to changing environments, have managed to survive in various agroecological zones. As such, goat adaptation mechanisms in response to climate change are important because they open the possibility of finding a solution to animal adaptability to climate change and addressing agricultural productivity and food insecurity.
It is important to note that the survival of animal species is dependent on the species’ ability to cope with or adapt to prevailing harsh climate conditions. To preserve animal productivity levels in an environment impaired by climate change, it is necessary for animal species to be genetically adapted with the ability to survive in diversified, harsh environmental conditions. Goats are among the animal species that can adapt to environmental heat stress by virtue of a composite of physiological, morphological, behavioral, and genetic characteristics. Their inherent physiological mechanisms allow goats to evolve in extreme temperatures with limited water resources [47]. Goats can repress the effect of high thermal stress by stirring behavioral responses, namely, feeding, water intake, shade seeking, and increased frequency of drinking.
Ambient temperature is a determinant of the feeding behavior of goats; hence, nocturnal feeding has been observed in goats, enabling them to avoid high temperatures during the day. In a related study [48], goats that were both heat stressed and water deprived actually preserved their milk production for 48 hours, notwithstanding a 20% decrease in body weight. This observation concurred with [49], who reported that despite elevated temperatures, goats never displayed physiological stress, and the mean values of magnitude reported were at the level of the limits of tolerance to heat stress. This is the likely reason goats maintained milk production.
Desert goats reared in accordance with traditional resource-poor systems were watered only once every 3–6 days, when water was scarce [50], and did not show much physiological stress. Studies of water deprivation in goats and other animal species in harsh environments are numerous and indicate that goats in West Africa, [51] East Africa, [52] and Southern Africa are more tolerant to water deprivation [53]. Feed intake was less influenced by water deprivation in adapted pygmy goats than in non-adapted breeds [54]. A report from [55] explained that goat tolerance to water deprivation was ascribable to their ability to limit urine and fecal water excretion at high ambient temperatures. It is important to note that drinking behavior in animals is influenced by water restriction; in this case, there is a tendency of water deprivation in goats, predisposing animals to drink large volumes of water in one bout upon watering. This behavior is more distinct in goats than in sheep [56]. Such physiological behavior in goats will be critical in the advent of variability in temperatures due to climate change where temperature is expected to rise. This implies that to mitigate the effects of an increase in ambient temperatures due to climate change, promoting animal species with an efficient physiological response to heat stress is recommended. In this case, goats are inclined to tolerate heat stress better than sheep [57]. The tendency of most goats to have loose skin and floppy ears makes them more heat tolerant than other animals [58].
The morphological mechanisms that goats possess to minimize the effects of heat stress relate to their body shape and size, light hair color, lightly pigmented skin, and small amount of subcutaneous fat. Physiological means include increased respiration rate, increased sweating rate, reduced metabolic rate, and change in endocrine function [59]. This emphasizes the choice and use of adaptive animal species such as goats that preserve their production and are able to produce and reproduce in climatic-stressed environments. Hence, understanding how to confront climate change while protecting vulnerable rural communities through sustained agricultural production using adaptive species is essential to meet food requirements at the household level. This can only be attained through promoting adapted animals, and this is where the goat emerges as an ideal candidate.
An efficient reproductive system coupled with a small body size can easily adjust the flock size to correspond to scarce feed resources and water. It is important to note that it is easy to facilitate the integration or promotion of goats’ rural communities because they are already embedded in the socioeconomic rural fabric. They can also be reared in limited space in addition to being popular with disadvantaged groups such as women.
Global climate change is primarily caused by GHG emissions that result in warming of the atmosphere [60]. The livestock sector contributes 14.5% of global GHG emissions; however, in ranking, goat production is known to emit relatively less methane than other domestic ruminants. Within animal production, the largest emissions are from beef followed by dairy and largely dominated by the methane produced during cattle digestion. The next largest portion of livestock GHG emissions is from methane produced during enteric fermentation in ruminants, a natural part of ruminant digestion where microbes in the first of four stomachs, the rumen, break down feed and produce methane as a byproduct. Methane is released primarily through belching. The status of goats relative to global GHG emissions will relatively address the challenge of maintaining a balance between productivity, household food security, and environmental preservation [61] in rural economies in sub-Saharan Africa. Indirect effects consider limitations on goat production from socioeconomic and environmental perspectives, which are mainly intended for decreasing GHG emissions, hence goat rearing has merits for rural economies’ adaptation to climate change and addressing the pertinent issue of food insecurity.
Arguably, regarding mitigation, the improvement of animal nutrition and genetics is essential because enteric fermentation is a major GHG emitter in livestock production. Climate models predict that without substantial reductions in GHG emissions, global temperatures will continue to increase, causing major changes in our weather patterns, environment, and way of life. Therefore, in this case, selection of adaptable animal species such as goats that maximize feed efficiency, increase fertility, and improve overall flock health within the confines of adverse effects of climate change is recommended [59].
Worldwide, considerable efforts have been made by international organizations and governments to battle climate change and ensure food for needy populations [61]. The present discussion offers an overview of the impact of climate change on the livelihoods of rural farm households and the adaptation strategies used to cope with the effects of climate change on agricultural production and food security. To thoroughly explain the interlinkage between climate change and agriculture is a hypothetical matrix (Figure 11) where notable consideration has been paid to gender dynamics and climate change; the focus is to try and explain how gender issues and adaptation strategies are interrelated in rural households that are exposed to climate-related adversities that impinge on agricultural production and food security and nutrition. The discussion exposes a visible linkage between gender relations and climate change adaptation in rural agrarian communities.
Women are more vulnerable to the harmful effects of climate change than men, which has compromised agriculture and food and nutrition security. This is because women are the major players in rural agrarian agriculture. This trend is worsened by social norms and customary laws that promote gender inequality in rural agrarian households. The discussion proposes that goat rearing is an entry point for gender equality while protecting women from the effects of climate change on agricultural production and food and nutrition security. The discussion uses a hypothetical conceptual matrix, focusing on the interplay between gender relations and climate change adaptation as a subsector of the matrix. The overview concludes that adaptive capacity can be enhanced through the advancement of gender equality and women’s empowerment through climate change knowledge and the promotion of goat rearing.
Poor resource livestock production systems, due to their reliance on specific climatic conditions, will in turn translate to the overall climate change effects impinging on productivity and food security. In this case, goats’ adaptive features will provide an effective solution to livestock production systems as a way to mitigate climate change. As climate change emerges as pivotal in shaping future livestock rearing systems and their performance, it will have more influence on what livestock species to raise. In this case, the choice of agroecological zone-specific, climate-resilient, thermotolerant species to sustain livestock production and enhance food security is imperative in sub-Saharan Africa. This is based on the premise that the choice or selection of adapted livestock species such as goats will be part of a strategy to offset the adverse effects of climate change on livestock production while preserving animal productivity, which in the short or long term sustains food security. The development and promotion of goat rearing is a viable option in the context of climate change mitigation where other animal species seem to be relatively vulnerable.
There is the possibility that as adverse climate effects continue impinging on rural livestock production, goat rearing will assume a critical role due to goats’ numerical strength and adaptive features such as feeding behavior and disease and heat tolerance, which gives them a comparative advantage for survival in harsh environmental conditions. In this regard, goats, due to their plethora of adaptive traits, emerge as a key facet in offsetting the destabilizing factors related to the uncertainties of climate change effects. Their ability to survive, reproduce, and produce in harsh environmental conditions is sufficient evidence for goats’ capacity for sustainable utilization in resource-poor farming communities. As indicated by their numerical proliferation in sub-Saharan African’s differentiated agroecological zones, goats have irrefutably proven that there are resilient livestock genetic resources that can be utilized to offset the effects of climate change and promote livestock production for increased food resources. Due to water scarcity, goats have the capacity to walk considerable distances in search of water and forage and make use of poor forage for their production and survival.
In view of this, rural, resource-poor production systems could be sustainable only in the long run if adaptive animal genetic resource species such as goats are promoted to offset adverse environmental effects and preserve performance levels. Goats’ adaptation characteristics are embedded in their genetics, which implies that they are inheritable and favor the survival of goat populations in harsh environmental conditions. It is important to note that the climate resilient potential of goats is influenced by both phenotypic and genotypic characteristics, and there are several candidate genes that are highly associated with the adaptation of small ruminants to heat stress. Therefore, species and/or breed selection focusing on resilience is a worthwhile tool for sustaining animal production in an increasingly challenging environment [62]. Of interest is that some animal species tolerate heat better than others, which may be critical in the choice of species to raise in the harsh climatic conditions of rural economies. Goats are less susceptible to environmental stress than other domesticated ruminant species [57].
Food and nutrition insecurity is a socioeconomic, environmental, and political subject; nevertheless, first and foremost, it is a gender issue that has resulted as a major cause and an outcome of compromised food production, food insecurity, and nutrition. Closing inequality gaps between females and males in food production systems will enhance women’s ability to make themselves heard and direct the course of their own lives [63]. There is overwhelming evidence that indicates a strong correlation between gender inequality, agriculture, and food and nutrition insecurity [11]. Social and economic inequalities between men and women undermine food security and hold back economic growth and advances in agriculture [28]. It has been acknowledged that livestock production is one of the core sectors to address perpetual food scarcity and to bring future food stability to sub-Saharan Africa [64]. Microlivestock such as goats have emerged as integral livestock subsectors, apart from their adaptability to harsh environmental conditions induced by climate change, and have enormous potential for enhancing animal production, consequently enhancing food security in rural communities [65].
Goat rearing emerges as an appropriate conduit for enhancing food security and rural livelihoods, in addition to acting as an entry point for gender equality and the empowerment of rural women [63]. Turner [66] supported that women play major roles in rearing sheep and goats; hence, any developmental projects in this area will empower women in food production and nutrition. It has been noted that failure to identify agricultural subsectors where women are effectively engaged, such as goat production, has been the major reason for the unsuccessful nature of most of the development initiatives on food production and security in rural economies [67]. In the same study, it was observed that livestock development projects fail partially because the roles of women are neglected in the planning process.
The goat is the animal of choice for purposes that are within the domain of women’s participation and responsibilities; hence, any goat-centered approach in rural development will consequently improve the lives of women in addition to enhancing food production overall. In most cases, due to increasing populations, the capacity for large ruminant animals, for example, cattle and buffaloes, has decreased; in this regard, shifting focus to micro livestock, such as goats, which are prolific and easy to manage, is recommended. Goat rearing in rural communities is one of the major components of livestock production systems in which women can be empowered and improve household agriculture, food, and nutrition. Goats have continued to play a significant role in the food chain and overall livelihoods of rural households, where they are largely the property of women and their children [45].
Goat rearing acts as an avenue to improve women’s capacity to develop as productive members of society while elevating their economic empowerment. In this case, goat rearing acts as a gender-transformative intervention that is decisive in building resilience and coping mechanisms among women and helps reduce vulnerability and improve food security and nutrition [67]. Quinsumbing et al. [68] observed that a reduction in the gap between men and women with respect to ownership of resources, decision making, and control is necessary for attaining food security. Women’s lack of participation in agricultural activities and general engagement with other community activities is symptomatic of entrenched norms and broader gender inequities. The shift in policy that acknowledges women’s critical role in food production and nutrition security has resulted in increasing women’s productive and economic capacity. However, there is a need to further examine the root cause of the entrenched gender inequalities that prevent women from fully participating, in agriculture and food production.
Gender inequalities in rural communities are prevalent and will persist because of a range of intertwined social, economic, and political factors that need to be addressed holistically. There is a proliferation of engendered development studies claiming the merits of focusing agricultural investments at women, especially in sub-Saharan Africa [69]. The argument is that increasing women’s empowerment will translate into an overall increase in agricultural productivity, hence reducing poverty and food insecurity. This notion is based on the premise that addressing food security requires more than the initiation of opportunities for individuals to earn sustainable livelihoods; it also demands the creation of a conducive environment for men and women to acquire those opportunities.
Achieving gender equality and women’s empowerment is critical to the success of addressing food insecurity. It has been proven that gender inequality has translated into a loss of opportunities or potential gains in livestock production and food security. Goat production, as a subsector of agricultural production, helps poor households increase their food security, reduce their vulnerability, and start a process that will move them out of poverty [70]. Regarding gender-cognizant perceptions of food security, it has been debated that gender-blind diagnoses of the challenges of food insecurity result in inadequate policy responses, which culminate in the perpetuation of food insecurity. Effective and promising strategies to address food insecurity need to be gender-just and environmentally sustainable in the long term.
Studies have proven that gender inequalities do not merely compromise not merely the capacity to produce and acquire food for good measurement of the nutritional security of that food, which is so central to household welfare [71]. Gender mainstreaming in agriculture has been proposed as an indispensable strategy for attaining gender equality and food security. However, this takes into account that agricultural growth is a key pathway toward addressing development issues such as food and nutrition insecurity and poverty, all of which climate change is already exacerbating [72]. There is conclusive evidence that when women are granted broader opportunities to participate in agricultural activity, the benefits expand far beyond themselves as individuals to their families and communities to societies and economies at large [28].
The development and promotion of goat production directs an ambitious path toward enhancing opportunities for women because it is critical to individual household welfare and socioeconomic development. Goat rearing as a strategy in addressing gender inequality builds on solid evidence that long-standing gaps between men and women impose real and significant disparities that need to be addressed. Since goat rearing is an important agricultural activity in rural economies of sub-Saharan Africa, its development and promotion is a promising intervention that can achieve tangible community results that can reorganize rural economies and positively address gender inequality.
There is overwhelming evidence that the provision of opportunities to women to partake in agricultural-related activities has positive effects on their families and communities in the form of improved household health, nutrition, and disposable income [63]. Advancing women’s participation and control over micro livestock, which includes goats, supported by training in husbandry and animal health, in addition to increasing access to education, veterinary, and financial services, is essential to improving households’ food security and nutrition.
Figure 13 models the interconnectedness of goat production and gender, climate.
Goat, gender, climate change, and food and nutrition security matrix. Source: Author.
change, and food security in rural economies in sub-Saharan Africa. Responses to climate change tend to focus on scientific and economic solutions, disregarding the critical importance of human and gender dimensions. Gender relations are still largely absent from debates on climate change and animal production-related issues. Generally, all inequalities often contribute to environmental change, and transforming them is therefore an indispensable part of a more effective and sustainable strategy to build resilience. This implies that addressing gender differentiation in livestock production and disparities in climate change and response knowledge will facilitate sustainable community resilience.
This sustainable and broad-based approach to gender, climate, and food and nutrition security takes into account the complexity of social, economic, and ecological aspects of rural agrarian communities through adequately acknowledging the interrelationship of these factors. This understanding has a provision of the development of gender-sensitive goat production policies that fit with complex livestock livelihood strategies, especially for resource-poor livestock keepers’ households. The matrix applies a gender perspective for understanding how goat production can be a pathway to food security possible through scrutiny of other elements such climate change and its impact on food security. Matrices are being modeled to explore different aspects of goat production, such as goat adaptability to adverse climatic conditions and less exposure to goat parasites, which makes goats an appropriate candidate for climate change mitigation strategies.
The two assumed goat production pathways out of food insecurity, climate change, and food security are (1) understanding disparities in livestock resource allocation and equal participation of men and women in goat productivity to address gender inequality and enhance food security, and (2) manipulating impact and response knowledge to reduce community vulnerability to climate change effects, thus increasing and sustaining goat productivity to address food insecurity and gender inequality. A general phenomenon is for men to own large livestock and particularly work animals, while women own micro livestock.
Strategies meant to enhance women’s access to and control over agricultural resources or other assets have resulted in the enhancement of food security as well as the wellbeing of women themselves [65, 68, 73]. Men and women often manage different types of animals and are responsible for different aspects of animal care. Given women’s traditional responsibility for household food security, their level of control over decisions about whether to sell or consume the family’s animal products, as well as how to use any income obtained from the sale of animal foods, could greatly determine the nutritional wellbeing of household members.
For each pathway, the findings are organized around key questions about the role of women and lessons about interventions targeting women. Assembling this information is a first step toward identifying some of the main gaps in our evidence base as well as some of the kinds of research and development interventions made in which species and value chains are most likely to benefit poor women and their families. Women play an important role in livestock management, processing, and marketing, acting as care providers, feed gatherers, and birth attendants. Despite their considerable involvement and contribution, women’s role in livestock production has often been underestimated, if not ignored.
There are potential effects of a goat-centered approach in shifting rural farm households toward gender-inclusive climate change adaptation to enhance food security and nutrition in sub-Saharan Africa. Regarding the matrix (Figure 11), the dependent factors of gender, climate change, and food security are deeply intertwined; hence, placing goat production as a redress factor, the matrix becomes an engendered livestock-based food security model that takes into account the adverse effects of climate change. The matrix is a departure from numerous previous hypothesized discussions that have focused on addressing gender inequality, food insecurity, and climate change adversity variables as isolated entities. This has posed challenges because these aspects of the socioeconomic and environmental nature of communities are interdependent, hence the need to establish a holistic approach in addressing these adversities. The matrix (Figure 11) is based on the understanding that goat rearing in rural economies will simultaneously curtail the risks of food insecurity and gender inequality and capitalize on the opportunities to offset adversities posed by climate change.
Gender differences in livestock production and disparities in climate change impact knowledge, and responses are the underlying root causes of vulnerability and food insecurity in rural communities in sub-Saharan Africa. Agriculture is a key livelihood activity, but it is vulnerable to climate change [1]. There is overwhelming documentation that climate change has a serious adverse impact on agricultural production and the livelihoods of millions of farmers, which has changed the lifestyle of rural people worldwide [74]. In recent decades, global awareness of the need to adapt agricultural systems and rural resource-poor livelihoods to the stressors emanating from climate change and variability has intensified. In tandem with this awareness, the importance of integrating gender aspects in climate change action in the agricultural sector has been recognized. Therefore, climate change discussion should afford adequate attention to gender-differentiated roles and vulnerability, in view of the fact that the impact of climate change has different implications for men and women. Lambrou and Piana [75] reported that women and men experience climate change impacts differently due to their socially constructed roles and responsibilities. Hence, it is imperative to design interventions that consider gender roles and guarantee protecting both men and women from the negative effects of climate change. This is based on the understanding that both men and women have a critical function to play in agriculture; hence, acknowledging gender distinctions facilitates appropriate, targeted interventions that offset vulnerability to climate change and contribute to gender equality and food security [74].
Assessment of adaptation, vulnerability, and resilience of communities against climate change and variability in rural communities can be applied using gender as a socioeconomic variable [76]. In most cases, there is a missing link to the scientific assessment of climate change impact through a gender integration approach to effectively mitigate and adapt to its impact. Consideration of the gender dimension in climate change is anticipated to culminate in effective interventions assisting both men and women in dealing with the impacts of climate change and bringing about resilient and comprehensive food security systems. Men and women can be effective agents of change with regard to environmental mitigation and adaptation only if they have equal access to information on climate change response. This implies that empowering men and women with climate change response knowledge can effectively advance sustainable agricultural production in rural communities as a result of offsetting the impact of climate change and enhancing food security. The provision of men and women with extensive theoretical and practical knowledge of climate change effects on agriculture should be given high regard. Broadening their role as agents of change in climate mitigation should be an integral part of the intervention strategy, and this aspect needs to be sufficiently exploited. However, the impact and response knowledge should be accurate and available to the general populace to accommodate anticipated changes.
Climate change is recognized as a global crisis, but responses tend to focus on scientific and economic solutions rather than addressing the vitally significant human and gender dimensions. Because of gendered social roles, women are in the front line of climate change impacts, such as droughts, floods, and other extreme weather events, yet they are the least responsible for environmental destruction. How then do we move toward more people-centered, gender-aware climate change policies and processes? How do we both respond to the different needs and concerns of women and men and challenge the gender inequalities that mean women are more likely to lose out than men in the face of climate change? The matrix helps to intervene through engendered climate change and food security perspectives to address the wider issues of voice, representation, and participation in general livestock production and decision making in rural communities.
The three pillars of this matrix are based on the acknowledgment of social, environment, and economic dimensions that influence rural communities, which are critical in discussions of gender inequality, food insecurity, and climate change vulnerability. The triple challenges seem to pose high social, environmental, and economic costs and lead to immense food insecurity in rural economies. The adoption of a goat-centered approach assumes that goat production is a predominant agricultural activity for livelihoods of rural communities in sub-Saharan Africa. The matrix provides avenues for pairwise analysis between subsectors such as gender and climate, gender and food security, and climate change and food security. Therefore, it is imperative that explicit attention be given to these relationships and how these dovetails affect goat production. An attempt to proffer a holistic approach that integrates scientific, technical, and economic aspects of goat farming with social and human dimensions is the major aim of this matrix.
Goats are deeply embedded in almost every sub-Saharan African rural economy and are a major agricultural subsector for most resource-poor farmers that can be exploited in addressing gender inequality, food insecurity, and climate change. However, it is important to note that the holistic perspective on these challenges is difficult to write about because of their direct and indirect connectedness. The matrix attempts to illustrate this phenomenon of the interconnection of gender, climate change, and food security.
The numerical status of goat species and composition in rural communities are critical to acknowledging trends in livestock ownership in rural economies and their impact on the vulnerability of resource-poor households to climate change and food insecurity. However, this matrix takes a holistic approach that is more difficult to achieve due to a variety of factors. Thus, it is imperative to improve our understanding of how the interaction of gender and climate change affects food security, particularly in resource-poor rural communities. It is also important to understand the pairwise relationships of different components of the framework. The understanding of gender differentiation in livestock production and disparities in climate change impact and response knowledge will lead to a more complete understanding of the influence of gender differentials in livestock production and disparities in climate change.
A goat-centered farming approach can help shift rural agrarian households and communities toward gender-inclusive climate change adaptation in agriculture to enhance food security and nutrition in sub-Saharan Africa. Gender inequality and climate change effects are compounding socioeconomic and environmental determinants that grossly compromise the stability of food production and food and nutrition security. Gender, climate change, agriculture, and food security are interrelated, and their dynamics are heterogeneous, complex, and rooted in social, economic, and institutional factors. The proposition in this chapter is that goat rearing can be a sustainable and holistic approach to addressing the triple challenges of gender inequality, climate change, and food and nutrition insecurity in rural communities of sub-Saharan Africa. This is grounded in the fact that goat rearing is an embedded integral component of a climate-smart livestock production strategy to increase rural agrarian resilience to climate change while improving food security and promoting gender equality. Apart from goats acting as an entry point for gender equality, they are a usable agro ecological, zone-specific, climate-resilient, thermotolerant animal species to sustain livestock production and enhance food and nutrition security. It is hypothesized that livestock production’s susceptibility to the vagaries of climate change can be mitigated by promoting adapted livestock species such as goats, which possess an ample degree of adaptation traits in terms of physiological, functional, and adaptive feeding behavior. This is based on the premise that climate change-induced variables continuously impinge on livestock productivity, which in most cases is the major cause of food and nutrition insecurity in rural agrarian households. Over the decades, goats have inherently acquired distinctive diverse physiological, morphological, and reproductive attributes that comparatively advance their survival and proliferation in unfavorable harsh heterogeneous agroecological niches of sub-Saharan Africa. In this regard, goats, due to their plethora of adaptive traits, emerge as a key facet in offsetting the destabilizing factors related to the uncertainties of climate change effects, in addition to goats being women’s animals. However, there is a need to develop mechanisms and promote the viability of goat production through various operational and institutional strategies. The challenge is that most sub-Saharan African countries do not provide adequate policy for, nor do they prioritize, goat productivity in rural communities. In conclusion, there is still significant prejudice and ignorance about the critical socioeconomic and environmental role of goats in farming. Despite the overwhelming evidence that goat rearing is hugely beneficial for resource-poor rural communities in sub-Saharan Africa.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. 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The natural resources are limited, and due to the natural disasters like sudden and severe abiotic stress factors, excessive floods, etc., the production capacities are changed per year. In contrast, the yield potential should be significantly increased to cope with this problem. Despite rich genetic diversity, manipulation of the cultivars through alternative techniques such as mutation breeding becomes important. Radiation is proven as an effective method as a unique method to increase the genetic variability of the species. Gamma radiation is the most preferred physical mutagen by plant breeders. Several mutant varieties have been successfully introduced into commercial production by this method. Combinational use of in vitro tissue culture and mutation breeding methods makes a significant contribution to improve new crops. Large populations and the target mutations can be easily screened and identified by new methods. Marker assisted selection and advanced techniques such as microarray, next generation sequencing methods to detect a specific mutant in a large population will help to the plant breeders to use ionizing radiation efficiently in breeding programs.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Özge Çelik and Çimen Atak",authors:[{id:"147362",title:"Dr.",name:"Özge",middleName:null,surname:"Çelik",slug:"ozge-celik",fullName:"Özge Çelik"},{id:"147364",title:"Prof.",name:"Çimen",middleName:null,surname:"Atak",slug:"cimen-atak",fullName:"Çimen Atak"}]},{id:"32846",doi:"10.5772/36950",title:"Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species",slug:"current-importance-and-potential-use-of-low-doses-of-gamma-radiation-in-forest-species",totalDownloads:5301,totalCrossrefCites:2,totalDimensionsCites:13,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"L. 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In this chapter, the following aspects of radiation treatment process are considered: sources of contamination and major contaminants of water and wastewater; primary processes in aqueous systems initiated by ionizing radiation; principal ways of contaminant conversion as consequences of primary processes (complete mineralization of organic compounds, partial decomposition of organic molecules resulted in detoxification, decolorization, disinfection of polluted water, and improvement in biological degradation of contaminant, polymerization of monomers’ contaminants, oxidation-reduction processes, and coagulation of colloids); sources of ionizing radiation; and main equipment applied in radiation technologies of aqueous system purification.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Igor E. Makarov and Alexander V. 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These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53780",title:"Gamma-Ray Spectrometry and the Investigation of Environmental and Food Samples",slug:"gamma-ray-spectrometry-and-the-investigation-of-environmental-and-food-samples",totalDownloads:2529,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Gamma radiation consists of high‐energy photons and penetrates matter. This is an advantage for the detection of gamma rays, as gamma spectrometry does not need the elimination of the matrix. The disadvantage is the need of shielding to protect against this radiation. Gamma rays are everywhere: in the atmosphere; gamma nuclides are produced by radiation of the sun; in the Earth, the primordial radioactive nuclides thorium and uranium are sources for gamma and other radiation. The technical enrichment and use of radioisotopes led to the unscrupulously use of radioactive material and to the Cold War, with over 900 bomb tests from 1945 to 1990, combined with global fallout over the northern hemisphere. The friendly use of radiation in medicine and for the production of energy at nuclear power plants (NPPs) has caused further expositions with ionising radiation. This chapter describes in a practical manner the instrumentation for the detection of gamma radiation and some results of the use of these techniques in environmental and food investigations.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Markus R. Zehringer",authors:[{id:"311750",title:"Dr.",name:"Markus R.",middleName:null,surname:"Zehringer",slug:"markus-r.-zehringer",fullName:"Markus R. Zehringer"}]},{id:"54118",title:"Gamma Rays from Space",slug:"gamma-rays-from-space",totalDownloads:2089,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"An overview of gamma rays from space is presented. We highlight the most powerful astrophysical explosions, known as gamma-ray bursts. The main features observed in detectors onboard satellites are indicated. In addition, we also highlight a chronological description of the efforts made to observe their high energy counterpart at ground level. Some candidates of the GeV counterpart of gamma-ray bursts, observed by Tupi telescopes, are also presented.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Carlos Navia and Marcel Nogueira de Oliveira",authors:[{id:"189908",title:"Dr.",name:"Carlos",middleName:null,surname:"Navia",slug:"carlos-navia",fullName:"Carlos Navia"},{id:"243084",title:"MSc.",name:"Marcel",middleName:null,surname:"De Oliveira",slug:"marcel-de-oliveira",fullName:"Marcel De Oliveira"}]}],onlineFirstChaptersFilter:{topicId:"227",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82739",title:"Experimental Breeder Reactor II",slug:"experimental-breeder-reactor-ii",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105800",abstract:"The Experimental Breeder Reactor II (EBR-II) operated from 1964 to 1994. EBR-II was a sodium-cooled fast reactor operating at 69 MWth producing 19 MWe. Rather than using a loop approach for the coolant, EBR-II used a pool arrangement where the reactor core, primary coolant piping, and primary reactor coolant pumps were contained within the pool of sodium. Also contained within the pool was a heat exchanger where primary coolant, which is radioactive, transferred heat to secondary, nonradioactive, sodium. The nuclear power plant included a sodium boiler building where heat from the secondary sodium generated superheated steam, which was delivered to a turbine/generator for electricity production. EBR-II fuel was metallic uranium alloyed with various metals providing significant performance and safety enhancements over oxide fuel. The most significant EBR-II experiments occurred in April 1986. Relying on inherent physical properties of the reactor, two experiments were performed subjecting the reactor to loss of primary coolant flow without reactor SCRAM and loss of the secondary system heat removal without reactor SCRAM. In both experiments, the reactor experienced no damage. This chapter provides a description of the most important design features of EBR-II along with a summary of the landmark reactor safety experiments.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope, Ryan Stewart and Edward Lum"},{id:"82712",title:"Idaho State University AGN-201 Low Power Teaching Reactor: An Overlooked Gem",slug:"idaho-state-university-agn-201-low-power-teaching-reactor-an-overlooked-gem",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105799",abstract:"A category of reactors called university research and teaching reactors, includes relatively high-power pool-type and low-power solid-core reactors. Many high-power university reactors are largely used for irradiations and isotope production. Their almost constant operation tends to impede student access. A university reactor can be particularly relevant to the university’s mission of preparing well-rounded students who have theoretical knowledge, reinforced by focused laboratory reactor experience. The solid-core Idaho State University Aerojet General Nucleonics (AGN) model 201 reactor operates at such a low power (5 W maximum) that it is not useful for isotope production activities. However, the AGN-201 reactor is well suited for teaching and research activities. The solid-core AGN-201 reactor requires no active cooling system, uses a simple shielding arrangement, and the very low operating power results in trivial burnup providing an operating lifetime exceeding many decades. It is thus worthwhile to examine the Idaho State University AGN-201 nuclear reactor more closely because it offers a wide range of research and teaching capabilities while being widely available to students.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope and William Phoenix"},{id:"81424",title:"Core Reload Analysis Techniques in the Advanced Test Reactor",slug:"core-reload-analysis-techniques-in-the-advanced-test-reactor",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.103896",abstract:"Since becoming a national user facility in 2007, the type of irradiation campaigns the Advanced Test Reactor (ATR) supports has become much more diverse and complex. In prior years, test complexity was limited by the computational ability to analyze the tests’ influence on the fuel. Large volume tests are irradiated in flux traps which are designed to receive excess neutrons from the surrounding fuel elements. Typically, fuel elements drive the test conditions, not vice versa. The computational tool, PDQ, was used for core physics analysis for decades. The PDQ code was adequate so long as the diffusion approximation between test and fuel element remained valid. This paradigm changed with the introduction of the Ki-Jang Research Reactor—Fuel Assembly Irradiation (KJRR-FAI) in 2015. The KJRR-FAI was a prototypic fuel element for the KJRR research reactor project in the Republic of Korea. The KJRR-FAI irradiation presented multiple modeling and simulation challenges for which PDQ was ill suited. To demonstrate that the KJRR-FAI could be irradiated and meet safety requirements, the modern neutron transport codes, HELIOS and MCNP, were extensively verified and validated to replace PDQ. The hybrid 3D/2D methodology devised with these codes made analysis of the ATR with KJRR-FAI possible. The KJRR-FAI was irradiated in 2015-2016.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Samuel E. Bays and Joseph W. Nielsen"},{id:"81555",title:"Nuclear Thermal Propulsion",slug:"nuclear-thermal-propulsion",totalDownloads:113,totalDimensionsCites:0,doi:"10.5772/intechopen.103895",abstract:"This chapter will cover the fundamentals of nuclear thermal propulsion systems, covering basic principles of operation and why nuclear is a superior option to chemical rockets for interplanetary travel. It will begin with a historical overview from early efforts in the early 1950s up to current interests, with respect to fuel types, core materials, and ongoing testing efforts. An overview will be provided of reactor types and design elements for reactor concepts or testing systems for nuclear thermal propulsion, followed by a discussion of nuclear thermal design concepts. A section on system design and modeling will be presented to discuss modeling and simulation of driving phenomena: neutronics, materials performance, heat transfer, and structural mechanics, solved in a tightly coupled multiphysics system. Finally, it will show the results of a coupled physics model for a conceptual design with simulation of rapid startup transients needed to maximize hydrogen efficiency.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Mark D. DeHart, Sebastian Schunert and Vincent M. Labouré"},{id:"81013",title:"Cyber-Informed Engineering for Nuclear Reactor Digital Instrumentation and Control",slug:"cyber-informed-engineering-for-nuclear-reactor-digital-instrumentation-and-control",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.101807",abstract:"As nuclear reactors transition from analog to digital technology, the benefits of enhanced operational capabilities and improved efficiencies are potentially offset by cyber risks. Cyber-Informed Engineering (CIE) is an approach that can be used by engineers and staff to characterize and reduce new cyber risks in digital instrumentation and control systems. CIE provides guidance that can be applied throughout the entire systems engineering lifecycle, from conceptual design to decommissioning. In addition to outlining the use of CIE in nuclear reactor applications, this chapter provides a brief primer on nuclear reactor instrumentation and control and the associated cyber risks in existing light water reactors as well as the digital technology that will likely be used in future reactor designs and applications.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Shannon Eggers and Robert Anderson"},{id:"79671",title:"Fault Detection by Signal Reconstruction in Nuclear Power Plants",slug:"fault-detection-by-signal-reconstruction-in-nuclear-power-plants",totalDownloads:105,totalDimensionsCites:0,doi:"10.5772/intechopen.101276",abstract:"In this work, the recently developed auto associative bilateral kernel regression (AABKR) method for on-line condition monitoring of systems, structures, and components (SSCs) during transient process operation of a nuclear power plant (NPP) is improved. The advancement enhances the capability of reconstructing abnormal signals to the values expected in normal conditions during both transient and steady-state process operations. The modification introduced to the method is based on the adoption of two new approaches using dynamic time warping (DTW) for the identification of the time position index (the position of the nearest vector within the historical data vectors to the current on-line query measurement) used by the weighted-distance algorithm that captures temporal dependences in the data. Applications are provided to a steady-state numerical process and a case study concerning sensor signals collected from a reactor coolant system (RCS) during start-up operation of a NPP. The results demonstrate the effectiveness of the proposed method for fault detection during steady-state and transient operations.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Ibrahim Ahmed, Enrico Zio and Gyunyoung Heo"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. 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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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