Zargar classification of corrosive esophageal injury.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6566",leadTitle:null,fullTitle:"Biomarker - Indicator of Abnormal Physiological Process",title:"Biomarker",subtitle:"Indicator of Abnormal Physiological Process",reviewType:"peer-reviewed",abstract:"This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of disease prognosis. Chapters in Part I focus on biomarkers for cancer, including breast cancer and pancreatic cancer, as well as circulating microRNA profiling in cancer biomarker discovery. Chapters in Part II focus on biomarkers of other diagnoses/diseases, including sepsis, childhood renal diseases, pulmonary diseases, Alzheimer's, leishmaniasis, and heart failure. This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of diseases prognosis. The book is of considerable importance for a broad range of people including researchers, clinicians, and university students.",isbn:"978-1-78923-667-5",printIsbn:"978-1-78923-666-8",pdfIsbn:"978-1-83881-558-5",doi:"10.5772/intechopen.71302",price:119,priceEur:129,priceUsd:155,slug:"biomarker-indicator-of-abnormal-physiological-process",numberOfPages:248,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"d50cce2242888a02ce742196a7dbf09f",bookSignature:"Ghousia Begum",publishedDate:"September 5th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6566.jpg",numberOfDownloads:13850,numberOfWosCitations:13,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:9,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:27,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 5th 2017",dateEndSecondStepPublish:"October 26th 2017",dateEndThirdStepPublish:"December 20th 2017",dateEndFourthStepPublish:"March 15th 2018",dateEndFifthStepPublish:"May 14th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"83759",title:"Dr.",name:"Ghousia",middleName:null,surname:"Begum",slug:"ghousia-begum",fullName:"Ghousia Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/83759/images/3549_n.jpg",biography:"Dr. Ghousia Begum got her Ph.D from Osmania University and continued her postdoctoral wok in the same University. In 1998 she was appointed Junior Scientist in Biology Division, CSIR- Indian Institute of Chemical Technology. She has significantly contributed to the field of Ecotoxicology, Biochemical and Molecular Mechanisms of Toxicity and Environmental Biology. Her research interests lies in how environmental changes, particularly toxicants affect physiological functions in aquatic animals especially in fish She is also working on alternative animal models which include lower invertebrates (Daphnia) and vertebrates (Zebra fish and edible fishes) for toxicity evaluation. She has published more than 30 research articles in reputed journals. She has more than 500 citations to her credit\nShe has been awarded YOUNG SCIENTIST AWARD for the year 1993 by National Environmental Science Academy (NESA), gold medal for academic excellence and SCIENTIST OF THE YEAR AWARD-2012 by NESA. She has edited a book entitled “ECOTOXICOLOGY” published by InTech. Presently she is editorial board member in eleven journals and editor of two journals. Many journals in the area of environmental biology, toxicology and related areas used her as peer reviewer.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Indian Institute of Chemical Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1016",title:"Medical Instrument Technology",slug:"medical-instrument-technology"}],chapters:[{id:"62000",title:"Biomarkers in Breast Cancer",doi:"10.5772/intechopen.77320",slug:"biomarkers-in-breast-cancer",totalDownloads:1689,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Breast cancer is the most common cancer in women and its incidence experienced an important increase, thanks to the introduction of a systematic screening. The increased incidence of early breast cancer has led to debates on its over-treatment, which may cause unnecessary harm to patients with favorable prognosis. Therefore, modern research is in the quest of finding the perfect prognostic marker to avoid overtreatment in patients with a favorable prognosis. In this perspective, many molecular markers have been studied in the last decades in order to provide both a useful prognostic tool, able to determine whether the cancer is likely to be indolent or aggressive, and a possible therapeutic target. In this chapter, we review the current knowledge about the principal biomarkers, which are usually immunohistochemically tested on breast surgical specimens, including ER and PR, Mib1/Ki-67 and HER2/neu expression. Furthermore, we will analyze other possible prognostic markers which may have in the future a key role in breast cancer management, such as several multigene panels (OncotypeDX, Mammaprint, NanoString Prosigma). Finally, we will discuss the role of genetic tests for some know genetic mutations associated with higher breast cancer susceptibility (BRCA1 and 2 genes).",signatures:"Serena Bertozzi, Ambrogio P Londero, Luca Seriau, Roberta Di Vora,\nCarla Cedolini and Laura Mariuzzi",downloadPdfUrl:"/chapter/pdf-download/62000",previewPdfUrl:"/chapter/pdf-preview/62000",authors:[{id:"74447",title:"Dr.",name:"Ambrogio P",surname:"Londero",slug:"ambrogio-p-londero",fullName:"Ambrogio P Londero"},{id:"167094",title:"Dr.",name:"Serena",surname:"Bertozzi",slug:"serena-bertozzi",fullName:"Serena Bertozzi"},{id:"234965",title:"Dr.",name:"Roberta",surname:"Di Vora",slug:"roberta-di-vora",fullName:"Roberta Di Vora"},{id:"234970",title:"Prof.",name:"Laura",surname:"Mariuzzi",slug:"laura-mariuzzi",fullName:"Laura Mariuzzi"},{id:"234971",title:"Dr.",name:"Carla",surname:"Cedolini",slug:"carla-cedolini",fullName:"Carla Cedolini"},{id:"235400",title:"Dr.",name:"Luca",surname:"Seriau",slug:"luca-seriau",fullName:"Luca Seriau"}],corrections:null},{id:"60358",title:"Circulating MicroRNA Profiling in Cancer Biomarker Discovery",doi:"10.5772/intechopen.75981",slug:"circulating-microrna-profiling-in-cancer-biomarker-discovery",totalDownloads:1184,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of approximately 22 nucleotides that regulate gene expression at the post-transcriptional level. Alterations in miRNA expression patterns correlate with a wide spectrum of pathological conditions, including cancer. miRNA profiling was mostly performed, in solid tissues, obtained by invasive diagnostic procedures. However, miRNAs in biofluids, such as serum and plasma, show high stability resulting from the formation of complexes with specific protein or incorporation within circulating exosomes or other microvesicles. Circulating miRNAs could be reliable biomarkers for early-stage cancer diagnosis, prognosis and response to therapy. In this chapter, we analyze the major pre-analytical and analytical challenges in experimental design for circulating miRNA detection, focusing on exosome fraction and microarray-based approach.",signatures:"Francesca Scionti, Pierosandro Tagliaferri, Pierfrancesco Tassone\nand Maria Teresa Di Martino",downloadPdfUrl:"/chapter/pdf-download/60358",previewPdfUrl:"/chapter/pdf-preview/60358",authors:[{id:"161607",title:"Prof.",name:"Pierosandro",surname:"Tagliaferri",slug:"pierosandro-tagliaferri",fullName:"Pierosandro Tagliaferri"},{id:"207596",title:"Prof.",name:"Pierfrancesco",surname:"Tassone",slug:"pierfrancesco-tassone",fullName:"Pierfrancesco Tassone"},{id:"228784",title:"Dr.",name:"Maria Teresa",surname:"Di Martino",slug:"maria-teresa-di-martino",fullName:"Maria Teresa Di Martino"},{id:"228789",title:"Dr.",name:"Francesca",surname:"Scionti",slug:"francesca-scionti",fullName:"Francesca Scionti"}],corrections:null},{id:"60624",title:"Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Mean Platelet Volume for Detection of Resectable Pancreas Cancer",doi:"10.5772/intechopen.76168",slug:"neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-mean-platelet-volume-for-detection-of-rese",totalDownloads:981,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Several biomarkers have been preferred for the early diagnosis of pancreatic adenocancer (PAC), but most are not ready to be included as part of the routine diagnostic algorithm because they still lack sensitivity, specificity or reproducibility. CA19-9 is the most widely used serum-based marker for the diagnosis and follow-up of pancreatic cancer. However, CA19-9 lacks sensitivity for early or small-diameter pancreatic cancers. For more than 3 decades, information on neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) has been widely available to health care practitioners, as part of the data provided in the full blood count. However, these biomarkers have more than used in the routine. The present chapter shares the prognostic significance of the hematological parameters in the light of our own findings and recent studies in the literature.",signatures:"Kemal Turker Ulutas, Inanc Samil Sarici and Ozgul Duzgun",downloadPdfUrl:"/chapter/pdf-download/60624",previewPdfUrl:"/chapter/pdf-preview/60624",authors:[{id:"213868",title:"Dr.",name:"Samil",surname:"Sarici",slug:"samil-sarici",fullName:"Samil Sarici"},{id:"214666",title:"Dr.",name:"Ozgul",surname:"Duzgun",slug:"ozgul-duzgun",fullName:"Ozgul Duzgun"},{id:"226644",title:"M.D.",name:"Kemal Turker",surname:"Ulutas",slug:"kemal-turker-ulutas",fullName:"Kemal Turker Ulutas"}],corrections:null},{id:"60889",title:"Biomarkers Utility for Sepsis Patients Management",doi:"10.5772/intechopen.76107",slug:"biomarkers-utility-for-sepsis-patients-management",totalDownloads:1458,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Sepsis is a global problem in either developing or developed countries and it is expected that the number of patients with sepsis and septic shock will tremendously increase in next decades also because of the antibiotic resistance growing issue worldwide. Criteria for sepsis diagnosis and prognosis have been recently established, but still a further understanding of the role of biomarkers in this setting is needed. Better utilization of biomarkers such as white blood cell count, CRP, lactate, procalcitonin, presepsin and bioadrenomedullin in sepsis patients, a state of the art on how to use them is needed. This review will focus on the actual recognized role of sepsis biomarkers not only for diagnosis purpose but also to improve patients treatment results in order to reduce mortality, hospital length of stay and cost related.",signatures:"Agustin Iskandar, Hani Susianti, Muhammad Anshory and Salvatore\nDi Somma",downloadPdfUrl:"/chapter/pdf-download/60889",previewPdfUrl:"/chapter/pdf-preview/60889",authors:[{id:"187348",title:"Prof.",name:"Salvatore",surname:"Di Somma",slug:"salvatore-di-somma",fullName:"Salvatore Di Somma"},{id:"230421",title:"Dr.",name:"Muhammad",surname:"Anshory",slug:"muhammad-anshory",fullName:"Muhammad Anshory"},{id:"230444",title:"Associate Prof.",name:"Agustin",surname:"Iskandar",slug:"agustin-iskandar",fullName:"Agustin Iskandar"},{id:"230467",title:"Dr.",name:"Hani",surname:"Susianti",slug:"hani-susianti",fullName:"Hani Susianti"}],corrections:null},{id:"60801",title:"Clinical Application of Coagulation Biomarkers",doi:"10.5772/intechopen.76589",slug:"clinical-application-of-coagulation-biomarkers",totalDownloads:1003,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Coagulopathy is of intense interest in the fields of emergency medicine, with many recent studies of coagulation biomarkers for clinical use. The occurrence of disseminated intravascular coagulation (DIC) also resulted in the activation of studies about the coagulopathy. At present DIC has been admitted in many clinical conditions and many coagulation biomarkers have been studied. Fibrin degradation product (FDP) and D-dimer are one type of coagulation biomarker. A characteristic of FDP and D-dimer is the rapid and dynamic elevation of their levels when fibrinolysis occurs in several acute diseases. In this chapter, we present the clinical application of FDP and D-dimer. In trauma, FDP and -dimer have been used for the evaluation of trauma severity, to predict the likelihood of hemorrhage and to evaluate the need for the transfusion of packed red blood cells. In cardiac pulmonary arrest (CPA), FDP and D-dimer have been useful for predicting the return of spontaneous circulation. Thus, the measurement of coagulation biomarkers is useful in the diagnosis and/or treatment of trauma and CPA.",signatures:"Makoto Aoki, Shuichi Hagiwara and Kiyohiro Oshima",downloadPdfUrl:"/chapter/pdf-download/60801",previewPdfUrl:"/chapter/pdf-preview/60801",authors:[{id:"230400",title:"Dr.",name:"Makoto",surname:"Aoki",slug:"makoto-aoki",fullName:"Makoto Aoki"},{id:"231817",title:"Dr.",name:"Shuichi",surname:"Hagiwara",slug:"shuichi-hagiwara",fullName:"Shuichi Hagiwara"},{id:"231818",title:"Prof.",name:"Kiyohiro",surname:"Oshima",slug:"kiyohiro-oshima",fullName:"Kiyohiro Oshima"}],corrections:null},{id:"60317",title:"Oxidative Status Pathways: Systemic Biomarkers",doi:"10.5772/intechopen.75543",slug:"oxidative-status-pathways-systemic-biomarkers",totalDownloads:955,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Systemic biomarkers (i.e. biomarkers of functioning of cellular pathways) offer a broad spectrum of diagnostic capabilities. There are several approaches to using systemic biomarkers that derive from exact needs of a researcher or a clinical specialist. First, analyzing a multifunctional and multi-systemic pathway in circulating cells (e.g. leukocytes) allows to gather generalized information on functioning of the organism. Second, there are numerous pathways that, even still in circulating cells, allow to assess risks of developing or stage of development of numerous diseases, including the leaders of non-infection diseases mortality—cardiovascular diseases. Third, biopsy specimens can readily be used to assess the exact signaling type of a disease (especially cancer) thus helping in selecting the best treatment option. Due to unique properties of the human oxidative status pathways that are discussed in the present chapter, diagnostics specialists are now acquiring an all-in-one toolbox for profiling and detecting almost any non-infectious and a broad range of infectious diseases. In addition to properties of the human oxidative status pathways opening these possibilities, this chapter considers exact systemic biomarkers deriving from this approach, reveals some examples of usage of the resulting diagnostic technology and provides instances of successful clinical application of the systemic biomarker approach.",signatures:"Peter Zolotukhin, Viktor Chmykhalo, Anna Belanova, Alexander\nDybushkin, Viktor Fedoseev and Dmitriy Smirnov",downloadPdfUrl:"/chapter/pdf-download/60317",previewPdfUrl:"/chapter/pdf-preview/60317",authors:[{id:"189455",title:"Ph.D.",name:"Peter",surname:"Zolotukhin",slug:"peter-zolotukhin",fullName:"Peter Zolotukhin"},{id:"194928",title:"M.Sc.",name:"Anna",surname:"Belanova",slug:"anna-belanova",fullName:"Anna Belanova"},{id:"230968",title:"Mr.",name:"Dmitry",surname:"Smirnov",slug:"dmitry-smirnov",fullName:"Dmitry Smirnov"},{id:"230969",title:"Mr.",name:"Alexander",surname:"Dybushkin",slug:"alexander-dybushkin",fullName:"Alexander Dybushkin"},{id:"240282",title:"BSc.",name:"Viktor",surname:"Chmykhalo",slug:"viktor-chmykhalo",fullName:"Viktor Chmykhalo"},{id:"240283",title:"Mr.",name:"Viktor",surname:"Fedoseev",slug:"viktor-fedoseev",fullName:"Viktor Fedoseev"}],corrections:null},{id:"60380",title:"Ovarian Reserve Markers: An Update",doi:"10.5772/intechopen.75521",slug:"ovarian-reserve-markers-an-update",totalDownloads:1031,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Ovarian reserve (OR) is defined as the pool of follicles available to provide eggs cells throughout the fertile age in each woman and define the potential of fertility to predict the reproductive lifespan of women. Several studies have focused on the clinical use in order to identify women with a decreased ovarian function and to improve the clinical approach to these patients. In this chapter we will describe different OR markers such as antimullerian hormone (AMH) and follicle stimulating hormone (FSH), count by ultrasound of antral follicles (AFC) and ovarian volume. The measure of OR markers has been reported as an effective test to predict a possible failure of reproductive capacity and important tool in the primary prevention of infertility and other related problems. Therefore, we will show the clinical use of these markers in both healthy and infertile women studies. Additionally, we describe the most recent and promising progress in the OR evaluation by construction of algorithms.",signatures:"Harold Moreno-Ortiz, Iván Darío Acosta, Elkin Lucena-Quevedo,\nLuis Alejandro Arias-Sosa, Alix Eugenia Dallos-Báez, Maribel Forero-\nCastro and Clara Esteban-Pérez",downloadPdfUrl:"/chapter/pdf-download/60380",previewPdfUrl:"/chapter/pdf-preview/60380",authors:[{id:"225381",title:"Dr.",name:"Maribel",surname:"Forero-Castro",slug:"maribel-forero-castro",fullName:"Maribel Forero-Castro"},{id:"241468",title:"Dr.",name:"Harold",surname:"Moreno",slug:"harold-moreno",fullName:"Harold Moreno"},{id:"241469",title:"BSc.",name:"Iván",surname:"Acosta",slug:"ivan-acosta",fullName:"Iván Acosta"},{id:"241471",title:"Dr.",name:"Elkin",surname:"Lucena",slug:"elkin-lucena",fullName:"Elkin Lucena"},{id:"241472",title:"BSc.",name:"Luis",surname:"Arias",slug:"luis-arias",fullName:"Luis Arias"},{id:"241473",title:"MSc.",name:"Alix",surname:"Dallos",slug:"alix-dallos",fullName:"Alix Dallos"},{id:"241474",title:"Dr.",name:"Clara",surname:"Esteban",slug:"clara-esteban",fullName:"Clara Esteban"}],corrections:null},{id:"59229",title:"Biomarkers of Common Childhood Renal Diseases",doi:"10.5772/intechopen.74016",slug:"biomarkers-of-common-childhood-renal-diseases",totalDownloads:944,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Novel biomarkers are now used in the diagnostic and prognostic evaluation of common kidney diseases in children. The increased scientific interest in these biomarkers is partly due to the remarkable progress in their discovery techniques, and their validation in clinical subjects. However, the wide variation in their sensitivity and specificity is still a major concern. In the identification of biomarkers of kidney injury, an ideal biomarker should be produced after organ injury in concentrations which directly correlates with the degree of injury; should be easily measured in body fluids; and should serve as a potential tool to monitor therapeutic response which is predicated upon a post-injury decrease in its concentration. This book chapter aims to highlight and discuss the novel biomarkers used in the diagnostic and prognostic evaluation of common acute diseases of the kidney in children, such as urinary tract infection (UTI) and acute kidney injury (AKI), as well as chronic kidney disease (CKD) secondary to idiopathic nephrotic syndrome (INS) and diabetic nephropathy (DN).",signatures:"Samuel N. Uwaezuoke",downloadPdfUrl:"/chapter/pdf-download/59229",previewPdfUrl:"/chapter/pdf-preview/59229",authors:[{id:"229083",title:"Associate Prof.",name:"Samuel N.",surname:"Uwaezuoke",slug:"samuel-n.-uwaezuoke",fullName:"Samuel N. Uwaezuoke"}],corrections:null},{id:"59880",title:"Molecular Diagnostics of Pulmonary Diseases Based on Analysis of Exhaled Breath Condensate",doi:"10.5772/intechopen.74402",slug:"molecular-diagnostics-of-pulmonary-diseases-based-on-analysis-of-exhaled-breath-condensate",totalDownloads:1735,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Measurements of biomarkers in exhaled breath condensate (EBC) extend a novel route for monitoring lung physiology and provide a beneficial insight into the pathophysiology of a specific disease. From the medicinal point of view, biomarkers present in EBC depict rather the processes occurring in lungs than those in the entire system. Therefore, particular profiles of exhaled biomarkers (e.g. cys-LTs, LTB4, 8-isoprostane, etc.) apparently reveal information exclusively applicable to differential lung disease diagnoses. This chapter describes the developed analytical method being applied to a clinical study for differential diagnostics of various phenotypes of asthma, chronic obstructive pulmonary disease, lung cancer, etc. In particular, having determined cys-LTs and LXs by the described method, and having applied them as biomarkers of bronchial asthma, their distinctive potential was demonstrated to differentially diagnose the specific disease, clearly suggesting this method to be reckoned as a beneficial alternative to existing diagnostic methods. Consecutively, the developed method was expanded to other asthma markers as aldehydes, nitrotyrosine, 8-isoprostane, PGE2, adenosine and finally, a supplementary study was carried out, engaging in detecting serotonin. The multi-marker screening and importance in the diagnostics of pulmonary diseases are referenced in the text as well.",signatures:"Tereza Kačerová, Petr Novotný, Ján Boroň and Petr Kačer",downloadPdfUrl:"/chapter/pdf-download/59880",previewPdfUrl:"/chapter/pdf-preview/59880",authors:[{id:"190932",title:"Associate Prof.",name:"Petr",surname:"Kačer",slug:"petr-kacer",fullName:"Petr Kačer"},{id:"197652",title:"Ms.",name:"Tereza",surname:"Kacerova",slug:"tereza-kacerova",fullName:"Tereza Kacerova"},{id:"207204",title:"Dr.",name:"Petr",surname:"Novotný",slug:"petr-novotny",fullName:"Petr Novotný"},{id:"207205",title:"Dr.",name:"Ján",surname:"Boroň",slug:"jan-boron",fullName:"Ján Boroň"}],corrections:null},{id:"61081",title:"Topological Biomarker of Alzheimer’s Disease",doi:"10.5772/intechopen.76633",slug:"topological-biomarker-of-alzheimer-s-disease",totalDownloads:898,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"For years, it has been assumed that the cerebral accumulation of pathologic protein forms is the main trigger of Alzheimer’s disease (AD) pathology; however, recent studies revealed strong evidences that the alternations in synaptic activity precede and affect the homeostasis of amyloid-beta and tau, both of which aggregate during AD. Given that the neuropathological changes, characteristic for AD, start decades before the onset of the first symptoms, when alternations become irreversible, it is crucial to find a biomarker that can detect the preclinical signs of disease, presumably synaptic dysfunction of specific cerebral areas. Here is presented a novel, a high potential neuroimaging biomarker that can detect the postsynaptic dysfunction of specific neural substrate located in medial prefrontal cortex (mPFC) during sensory gating processing of a simple auditory stimulus. The magnetoencephalography-based localization of mPFC gating activation has the potential not only to detect symptomatic AD but also to become a predictor of cognitive decline related to the pathophysiological processes of AD, both at the individual level. The strengths of proposed biomarker lie in the simplicity of using a binary value, i.e., activated or not activated a neural generator along with its potential to follow the evolution of the pathophysiological process of disease from preclinical phase. The novel biomarker does not require estimation of uniform cutoff levels and standardization processes, the main problems of so far proposed biomarkers. Ability to individually detect AD pathology during putative preclinical and clinical stages, absolute noninvasiveness, and large effect size give this biomarker a high translation capacity and clinical potential.",signatures:"Sanja Josef Golubic",downloadPdfUrl:"/chapter/pdf-download/61081",previewPdfUrl:"/chapter/pdf-preview/61081",authors:[{id:"225125",title:"Ph.D.",name:"Sanja",surname:"Josef Golubic",slug:"sanja-josef-golubic",fullName:"Sanja Josef Golubic"}],corrections:null},{id:"60134",title:"Biomarkers in Leishmaniasis: From Basic Research to Clinical Application",doi:"10.5772/intechopen.75315",slug:"biomarkers-in-leishmaniasis-from-basic-research-to-clinical-application",totalDownloads:1121,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Leishmania is an intracellular protozoan parasite and the etiological agent of a vector-borne disease known as leishmaniasis. This neglected tropical disease exhibits high morbidity and mortality putting at risk people from multiple countries worldwide. It is endemic in 97 countries and 700,000–1 million new cases are estimated to occur each year. Leishmaniasis management is very challenging, the symptoms are non-pathognomonic (in both human and canine populations) and the treatments are associated with significant toxicity. Therefore, the need for detection in symptomatic and asymptomatic hosts is important to tackle the dissemination of infection, increasing the need for highly specific biomarkers. In this complex the available disease biomarkers will be addressed in a retrospective manner, focusing on their development from laboratory to their direct use in clinical settings.",signatures:"Sofia Esteves, Inês Costa, Célia Amorim, Nuno Santarem and\nAnabela Cordeiro-da-Silva",downloadPdfUrl:"/chapter/pdf-download/60134",previewPdfUrl:"/chapter/pdf-preview/60134",authors:[{id:"169577",title:"Dr.",name:"Anabela",surname:"Cordeiro-Da-Silva",slug:"anabela-cordeiro-da-silva",fullName:"Anabela Cordeiro-Da-Silva"},{id:"233018",title:"Dr.",name:"Nuno",surname:"Santarem",slug:"nuno-santarem",fullName:"Nuno Santarem"},{id:"233019",title:"Prof.",name:"Celia",surname:"Amorim",slug:"celia-amorim",fullName:"Celia Amorim"},{id:"242895",title:"MSc.",name:"Sofia",surname:"Esteves",slug:"sofia-esteves",fullName:"Sofia Esteves"},{id:"242896",title:"MSc.",name:"Inês",surname:"Costa",slug:"ines-costa",fullName:"Inês Costa"}],corrections:null},{id:"59812",title:"Biomarkers and Heart Failure",doi:"10.5772/intechopen.74798",slug:"biomarkers-and-heart-failure",totalDownloads:853,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Heart failure (HF) represents fatal endpoint of all cardiovascular diseases. Acute and chronic HF is a complex, heterogeneous syndrome consisting of many overlapping syndromes making its diagnosis and treatment more challenging. There is no single test for diagnosis of HF, and diagnosis is based on clinical judgment driven by a combination of history, physical examination, and appropriate tests. Despite improvements in clinical management within the last 50 years, it has still been a disease of poor prognosis. Attempts to further improve its prognosis can only be achieved by understanding pathophysiology of HF clearly and finding, developing, and using appropriate and new clinical biochemical markers for diagnosis of each different clinical subtype and hence unique intervention of that specific subtype of HF. This review is an overview of biomarkers, which are either currently used in the clinical practice or hold promise for future use in patients with both chronic and acute HF.",signatures:"Hakan Altay",downloadPdfUrl:"/chapter/pdf-download/59812",previewPdfUrl:"/chapter/pdf-preview/59812",authors:[{id:"188670",title:"Associate Prof.",name:"Hakan",surname:"Altay",slug:"hakan-altay",fullName:"Hakan Altay"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"677",title:"Ecotoxicology",subtitle:null,isOpenForSubmission:!1,hash:"1925c37f0dfc6eb0d8448aa22777eb9e",slug:"ecotoxicology",bookSignature:"Ghousia Begum",coverURL:"https://cdn.intechopen.com/books/images_new/677.jpg",editedByType:"Edited by",editors:[{id:"83759",title:"Dr.",name:"Ghousia",surname:"Begum",slug:"ghousia-begum",fullName:"Ghousia Begum"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6095",title:"Insecticides",subtitle:"Agriculture and Toxicology",isOpenForSubmission:!1,hash:"4e249884334e8155c1e57e34b7d8c9d2",slug:"insecticides-agriculture-and-toxicology",bookSignature:"Ghousia Begum",coverURL:"https://cdn.intechopen.com/books/images_new/6095.jpg",editedByType:"Edited by",editors:[{id:"83759",title:"Dr.",name:"Ghousia",surname:"Begum",slug:"ghousia-begum",fullName:"Ghousia Begum"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4576",title:"Rehabilitation Engineering",subtitle:null,isOpenForSubmission:!1,hash:"8c4fcda89f1173a1ec31aabd7f4ac894",slug:"rehabilitation-engineering",bookSignature:"Tan Yen Kheng",coverURL:"https://cdn.intechopen.com/books/images_new/4576.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6655",title:"Medical Internet of Things (m-IoT)",subtitle:"Enabling Technologies and Emerging Applications",isOpenForSubmission:!1,hash:"af6863294c037ec8e4f13785cb65e6fb",slug:"medical-internet-of-things-m-iot-enabling-technologies-and-emerging-applications",bookSignature:"Hamed Farhadi",coverURL:"https://cdn.intechopen.com/books/images_new/6655.jpg",editedByType:"Edited by",editors:[{id:"171143",title:"Dr.",name:"Hamed",surname:"Farhadi",slug:"hamed-farhadi",fullName:"Hamed Farhadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Functional foods contain either supplements or other additional ingredients designed to improve the health of the general population. Foods are being examined and improved which may reduce chronic disease risk and optimize health. Japanese has first developed the concept of functional foods in 1980. At that time, their health care costs were escalating and the Ministry of Health and Welfare initiated to approve some foods which were documented with their health benefits and used for improving the health of the aging population [1].
Functional food components are bioactive compounds used in the manufacture of functional foods. They are potentially beneficial compounds found either naturally in foods or added to them as functional ingredients. The functional food components are carotenoids, isothiocyanates, dietary fiber, phenolic acids, fatty acids, plant stanols and sterols, flavonoids, polyols, soy protein, prebiotics and probiotics, phytoestrogens, vitamins, and minerals. Research-based evidence suggested that there is a relationship between functional food components, health, and well-being [2]. Therefore, functional food components can be used in the treatment and prevention of diseases, as they have health-promoting roles at various stages of disease control. Phytochemicals are plant-derived, non-nutritive, and biologically active functional food components that function in the body to prevent certain non-communicable diseases [3]. About 900 phytochemicals are found in foods and 120 g of foods or vegetables may have around 100 different types of phytochemicals [4]. The earlier concept was that functional food components occur mainly in plant foods, such as whole grain, fruits, and vegetables. However, functional food components are also found in animal products; these are milk, fermented milk products, and cold-water fish. These animal source food components are probiotics, prebiotics, symbiotic, conjugated linolenic acid, long-chain omega-3, -6, and -9 polyunsaturated fatty acids, etc.
Functional foods can be made by different approaches, such as (1) eliminating harmful components from the food (e.g. allergic protein), (2) increasing the concentration of a component in the food by fortification with micronutrients or any other ingredient, (3) eliminating excessive component mainly a macronutrient like fats and producing a beneficial component such as chicory inulin, (4) increasing stability or bioavailability of a component to produce a functional effect or to reduce the disease risk, and (5) adding a new component in the foods which has the beneficial effect, e.g. antioxidant.
In this chapter, functional food ingredients, including their sources and physiological functions, are discussed.
The carotenoids are the most widespread and important fat-soluble pigments in nature and they have varied health functions. Most carotenoids consumed foods are beta-carotene, alpha-carotene, gamma-carotene, lycopene, lutein, beta-cryptoxanthin, zeaxanthin, and astaxanthin.
Carotenoids are available in plants, fruits, flowers, algae, and photosynthetic bacteria. The other sources of carotenoids are non-photosynthetic bacteria, yeasts, and molds.
Carotenoids are used as antioxidants in dietary supplements. They are also used as colors in foods and beverages and as pigments in poultry and fish farm, and as food ingredients. Carotenoids have an important role in human health. The main dietary source of vitamin A is beta-carotene. Protective effects of carotenoids have been identified against serious disorders, such as cancer [5], heart disease [6], and degenerative eye disease [7]. The role of carotenoids as antioxidants and as regulators of the immune response system is also recognized.
Dietary fibers are the portion of plant-derived foods. They cannot be fully fragmented by human digestive enzymes. Fibers are non-starch polysaccharides, such as cellulose, hemicellulose, galactooligosaccharides, polyfructose, gums, mucilages, pectins, and lignin. These are soluble or insoluble fibers that pass through the stomach and small intestine undigested, but they are fermented by bacteria in the colon when they reach the large intestine.
Beans, whole grains, brown rice, popcorn, nuts, baked potato with skin, berries, bran cereal, oatmeal, and vegetables are the sources of dietary fibers.
Fibers are fermented and produced short-chain fatty acids in the colon that provide important health benefits. Some fibers are manufactured and added to food products to provide similar health benefits without adding calories called functional fibers. These are cellulose, polydextrose, maltodextrin, and inulin. There are several potential health benefits of the consumption of dietary and functional fibers. Fibers reduce the incidence of constipation [8], irritable bowel syndrome [9], lower cholesterol, and reduce the incidence of coronary and cardiovascular heart diseases [10], prevent obesity [11] and diabetes [12], avoid colon cancer [13], and increase survival in breast cancer [14]. However, there are some adverse effects of excessive intake of dietary fiber, such as intestinal obstruction (in susceptible individuals), dehydration (due to a fluid imbalance), increase in intestinal gas, resulting in distention and flatulence, and reduced absorption of vitamins, minerals, proteins, and calories from the gut [15].
Essential fatty acids (EFAs) cannot be synthesized by the human body but the body requires them for good health and therefore, they must be obtained through diet. Essential fatty acids are long-chain polyunsaturated fatty acids. They are called “good fats” and they increase the levels of high-density lipoprotein (HDL) and decrease the levels of low-density lipoprotein (LDL). Alpha linoleic acid and linolenic acid are the primary essential fatty acids in the human body.
Sources of essential fatty acids are mackerel, salmon, cod liver oil, herring, oysters, soybeans, sardines, flax seeds, anchovies, caviar, walnuts, chia seeds, and canola oils.
Essential fatty acids help in the absorption of important nutrients and expelling of harmful waste products that support the reproductive, cardiovascular, nervous systems, and immune. They are also important for proper growth, neural development, and maturation of sensory systems in children. Other important roles of EFAs are to increase the production of prostaglandins that regulate body functions, such as blood pressure, heart rate, blood clotting, conception, and fertility. EFAs also play an important role in immune function by regulating inflammation and encouraging the body to fight infection [16]. Essential fatty acids are beneficial for those suffering from rheumatoid arthritis [17] and reduce tenderness in joints, swelling, and diminish morning stiffness. It has also been observed that EFAs are important elements for asthma [18], depression [19], bipolar disorder schizophrenia [20], hypertension [21], heart diseases [22], burns [23], photodermatitis, acne or psoriasis [24], cholesterol [25], obesity [26], insulin sensitivity [27], osteoporosis [28], attention deficit disorder or attention deficit hyperactivity disorder [29], age-related macular degeneration [30], dry-eye conditions, such as Sjögren’s syndrome [31]. Consumption of sufficient amounts of foods rich in omega-3 fatty acids reduces the risk of colorectal [32], breast cancer [33], and prostate cancer [34].
Isothiocyanates are compounds produced by hydrolysis of glucosinolates that are precursors of cruciferous vegetables. Some isothiocyanates are volatile and evaporated below the boiling point. Isothiocyanates hydrolyze at higher cooking temperatures and their bioavailability is affected by microwaving at high power [35].
Good sources of isothiocyanates are cruciferous vegetables, such as broccoli, brussels sprouts, watercress, Japanese radish, cabbage, cauliflower, and kale.
Several studies revealed that isothiocyanates and their metabolites decrease the risk of developing different types of cancer, such as stomach, breast, liver, esophagus, lung, small intestine, and colon [36, 37]. Isothiocyanates effect
Flavonoids are pigments synthesized by plants and there are many different subclasses, each comprising many different compounds, such as isoflavones (biochanin A, daidzin, daidzein, formononetin, glycitein, genistein); flavononols (astilbin, genistin, taxifolin, engeletin); anthocyanidins (cyanidin, malvidin, delphinidin, apigenin, peonidin, pelargonidin, petunidin); chalcones (okanin, butein); flavonols (isorhamnetin, quercetin, kaempferol, myricetin); flavanols (positive-catechin, negative-epicatechin, positive-gallocatechin, negative-epigallocatechin, negative-epicatechin gallate); flavones (apigenin, luteolin, chrysin, rutin); flavanones (eriodictyol, isosakuranetin, hesperidin, naringin, naringenin, taxifolin) [41].
Sources of flavonoids are fresh capers, elderberry juice, dried parsley, sorrel, red onions, rocket lettuce, fresh cranberries, goji berries, cooked asparagus, blackcurrants, dried oregano, grapefruit, lemons, orange juice, limes, oranges, grapefruit juice, artichokes, green tea, black tea, dried cocoa, dark chocolate, blackberries, cooked broad beans, pecan nuts, red table wine, apples, peaches, dried parsley, aronia, green pepper, bilberries, chickpeas, black currants, American bilberries, red cabbage, red currants, raspberries, and strawberries.
There are several health benefits of flavonoids, including antiallergic, antioxidant activities, antiviral [42], antitoxic, antifungal [43], antibacterial [44] and anti-inflammatory [45]. Recent researches identified the many defensive roles of flavonoids, these are eye diseases [46], heart diseases [47], hemorrhoids [48], diabetes [49], neurodegenerative diseases, such as Alzheimer’s or Parkinson’s [50], gout [51] and periodontal disease [52]. Flavonoids are also used for the prevention and treatment of different types of cancer, such as prostate [53], ovarian [54], pancreatic, colon, breast [55], leukemia, lung [56], esophageal [57], hepatocellular carcinoma [58], and renal cell carcinoma [59].
Phenolic acids contain a phenolic ring and a carboxyl functional group. Some examples of phenolic acids are protocatechuic acid, vanillic acid, p-hydroxybenzoic acid, ferulic acid, caffeic acid, p-coumaric acid, sinapinic acid, and syringic acid. Phenolic acids are absorbed through the walls of the intestine and serve beneficial roles, such as antioxidants and protect cellular damage by free-radical oxidation reactions.
Sources of phenolic acids are cereals, oilseeds, legumes, vegetables, fruits, beverages, and herbs. Besides these sources, they are also found in all food groups.
Phenolic acids have several health benefits, such as intake of phenolic acids decrease the risk of cardiovascular diseases, certain cancers, type II diabetes, and neurodegenerative disorders [60, 61, 62], through multiple putative mechanisms of actions, including antioxidation, glucoregulation, anti-inflammation, antiproliferation, and microbial modulation. Russo et al. [63] found a negative relationship between dietary intake phenolic acids (e.g. ferulic acid and caffeic acid) and prostate cancer and they showed that both phenolic acids are associated with reduced prostate cancer. Also, immunoregulation diseases, asthma, and allergic reactions are protected by caffeic acid which is phenolic acid. Caffeic acid has a positive role against colon cancer [64] and it has inhibitor properties of HIV-1 that act as a potential antiviral therapy [65]. It is also found that a higher intake of phenolic acids is significant lower mean systolic and diastolic blood pressure compared to a lower intake of phenolic acids [66].
Plant stanols and sterols are a group of substances made in the plant. The most important and ample of plant sterol is sitosterol. However, campesterol and stigmasterol are also significant quantitative of sterol. They reduce the absorption of cholesterol in the intestine and help to lower low-density lipoprotein (LDL) cholesterol levels in the blood without affecting high-density lipoprotein (HLD) cholesterol levels.
Sterols and stanols are found in the highest amount in foods, such as fruits, vegetables, seeds, nuts, legumes, cereals, and vegetable oils.
Plant sterols work as an anti-inflammatory, antioxidant [67], and antiatherosclerosis. Phytosterols have antifungal activity and protect against ulcers [68]. The intake of plant sterols can prevent different types of cancer, such as the esophagus, prostate [69], lung [70], breast [71], ovary [72], stomach, and endometrial [73]. LDL-cholesterol is a risk factor for cardiovascular diseases. Plant sterols or stanols prevent absorption of LDL cholesterol from the gut, as a result, serum levels of LDL are lower, and assumed that lowering LDL-cholesterol is expected to lower cardiovascular diseases.
Polyol is an organic compound and low-calorie carbohydrate-based sweetener. It is a hydrogenated version of carbohydrates. Its taste and texture are like sugar with half the calories. Polyols are used as sugar-free and low-calorie ingredients in many foods. There are various types of polyols, such as erythritol, isomalt, polyglucitol, lactitol, polyglycitol, mannitol, sorbitol, maltitol, and xylitol.
Polyols are found in some fruits, vegetables, and mushrooms.
Polyols are used in different industries for making foods, such as ice cream, chewing gums, frozen desserts, candies, and baked goods [74]. They are also used for frostings, canned fruits, beverages, yogurt, and tabletop sweeteners. Polyols have some important health benefits and they maintain good oral health [75]. They are also used for weight control and reduction of dietary glycemic load [74]. Polyols may play an important role in the maintenance of human digestive health as these are low digestible carbohydrates [76]. Sometimes overconsumption of polyol-containing foods may have laxative effects [74].
Soy protein is extracted from soybean and hence, it is a complete plant-based protein and it contains adequate amounts of all the essential amino acids. Health benefits of soy protein depend on consumption per day. Per person need to consume 25 g of soy protein or more every day to get results.
Whole soybeans are the source of soy protein and dietary fiber. Some selected soy food products are soya sauce (2 g protein of 18 g soy sauce), cooked and fermented soy (5 g protein of 28 g cooked and fermented soy), soybean curd (6 g protein of 84 g soybean curd), and soy veggie burger (11 g protein of 70 g soy veggie burger).
Soy protein has many potential health benefits. Beneficial effects of soy protein products on women are improvement of diet and cardiovascular status, prevention of certain types of cancer, health improvement following menopause, and obesity prevention [77]. Xiao et al. [78] have shown some chemopreventive activity of soy protein. The potential role of consumption of soy protein is reducing body weight and fat mass which reduces plasma cholesterol and triglycerides [79]. Soy protein may reduce the risk of cardiovascular disease, stroke, and coronary heath disease.
Phytoestrogens (PEs) are the compounds found in plans and they are not generated within the endocrine system in the human body and are consumed by eating phytoestrogenic plants. They have roles in the metabolism of proteins, carbohydrates, fats, and minerals in the human body and they act as estrogen hormone in the reproductive cycle in women [80]. There are three types of phytoestrogens, such as lignans (enterolactone or enterodiol), coumestans (coumestrol), and isoflavones (genistein, daidzein, glycitein).
The greater sources of phytoestrogens are soybeans, soy beverages, tofu, tempeh, linseed (flax), wheat, berries, sesame seeds, oats, barley, lentils, dried beans, rice, alfalfa, mung beans, apples, wheat germ, carrots, rice bran, and soy-linseed bread.
There are several health benefits of phytoestrogens. They affect the cardiovascular system [80] and skeleton and reduce the incidence of osteoporosis [81] and menopausal symptoms [82]. Phytoestrogens have cell proliferation inhibiting factors that prevent cancer. They have positive effect on prostate cancer [83], breast cancer [84], thyroid cancer [85], colorectal cancer [86], skin cancer [87] and endometrial cancer [88]. Soy foods containing PEs improve control of blood glucose and insulin levels [89]. There are antibacterial and fungistatic activities in some phytoestrogens which play an antiviral role [90].
There are two types of bacteria in our body, such as good bacteria and bad bacteria. Probiotics are living bacteria that provide health benefits by improvement of the balance of the intestinal microflora [91] when ingested in an adequate amount. Some yeasts also work as probiotics. There are so many types of probiotics, but
Some best probiotic foods are yogurt, traditional buttermilk, pickles, kombucha, kimchi, sauerkraut, cheese, and kefir.
Probiotic is used for the treatment of diarrhea [92],
Prebiotics are non-digestible fibers present in plants and help healthy bacteria to grow in the gut and make the human digestive system work better. Most of the prebiotics are oligosaccharides that stimulate selectively the growth of
Main sources of prebiotics are fruits, vegetables, and whole grains, such as apples, artichokes, asparagus, bananas, barley, berries, chicory, cocoa, dandelion greens, flaxseed, garlic, green vegetables, leeks, konjac root, legumes, oats, tomatoes, onions, soybeans, wheat, and yacon root. Also, some foods are fortified with prebiotics, for example, baby formula, bread, cereal, cookies, and yogurt.
Prebiotics work as anticarcinogenic, antimicrobial, and antiosteoporotic activities. Prebiotics are also used for the treatment of constipation, hepatic encephalopathy, and inflammatory bowel disease. There is a beneficial role of prebiotics in diabetes mellitus. Prebiotics also have an important role in improving mineral absorption and balance and enhancing the colonic absorption of some minerals. Prebiotics also ferment foods faster in the intestine and prevent constipation. Prebiotics reduce sepsis and mortality in premature and low-birth-weight infants [104].
Synbiotics are the combined products of both probiotics and prebiotics. The advantage of the combination of beneficial bacteria is the encouragement of beneficial bacterial growth. Synbiotics are produced by combinations of
As symbiotics are the combined products of prebiotics and probiotics, so the sources of symbiotics are the same as probiotics and prebiotics. However, this combination is produced commercially.
Evidence suggested that symbiotics can reduce sepsis, lower respiratory tract infection, and mortality among low-birth-weight infants [105].
Vitamins are organic molecules and essential for the proper functioning of the human body. Vitamins are required in small amounts obtained from a correct diet. There are two types of vitamins such as fat-soluble vitamins and water-soluble vitamins. Fat-soluble vitamins are A, D, E, and K and they can be stored in the body. On the other hand, water-soluble vitamins are C and B-complex, such as vitamins B6, B12, niacin (B3), riboflavin (B2), biotin (B7), thiamine (B1), pantothenic acid (B5), and folic acid (B9). They cannot be stored in the body because the excess ingested is eliminated through human fluids, such as urine and transpiration, and hence necessary to ingest a daily amount of these vitamins [106].
There are different forms of vitamin A, such as retinol, retinal, retinoic acid, and all known as retinoids.
The best sources of vitamin A are beef liver, cod liver oil, spinach, sweet potato, carrots, broccoli, black-eyed peas, mango, sweet red pepper, cantaloupe, dried apricots, pumpkin pie, tomato juice, and herring.
Vitamin A plays an important role in many processes in the body, including immune function, reproduction, healthy vision, proper functioning of the heart, kidneys, lungs, and other organs, skink health and growth development. Vitamin A also helps to prevent lung and breast cancer [107]. Vitamin A can be used for the treatment of leukemia [108], skin disorders, and retinitis pigmentosa [109].
Vitamin B-complex is a product that is composed of B vitamins, such as thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), vitamins B6, biotin (B7), folic acid (B9), and B12.
Adequate amount of vitamins B sources are milk, cheese, eggs, liver and kidney, meat (chicken and red meat), fish (tuna, mackerel, and salmon), shellfish (oysters and clams), and dark green vegetables (spinach and kale).
Vitamin B-complex has several health benefits:
Thiamin/thiamine (B1) is used for the treatment of Alzheimer’s disease [110], congestive heart failure [111], and cancer [112].
Riboflavin (vitamin B2) is used to prevent cataracts [113] and migraine headaches [114].
Niacin (B3) is used to prevent insulin-dependent diabetes mellitus [115]. It has a significant role to treat high cholesterol and cardiovascular disease [116].
Pantothenic acid (B5) can help in wound healing [117] and play an important role to maintain cholesterol levels [118].
Vitamin B6 has a vital role to prevent cardiovascular disease [119], kidney stones, and immune and cognitive functions [120]. It is also used for the treatment of premenstrual syndrome [121]. Vitamin B6 can protect from side effects of oral contraceptives, nausea, and vomiting in pregnancy [122] and reduce depression.
Biotin (B7) is used for the treatment of diabetes [123] and in the prevention of some birth defects [124]. It plays a vital role in the treatment of cholesterol [125], brittle fingernails [126], seborrheic dermatitis [127], and hair loss.
Folic acid (B9) is used to prevent some pregnancy complications, such as fetal neural tube defects [128]. It may be used to prevent certain heart defects and limb malformations [129] and birth defects [130]. Folic acid is used to prevent colorectal and breast cancer [131], heart diseases [132], Alzheimer’s disease, and cognitive impairment [133].
Vitamin B12 plays an important role in the prevention of neural tube defects, cancer [134], cardiovascular disease [135], depression, Alzheimer’s disease, and dementia [136].
Vitamin C (ascorbic acid) is a very effective nutrient and the main sources of vitamin C are citrus fruit (oranges and orange juice), strawberries, peppers, broccoli, blackcurrants, brussels sprouts, and potatoes. It plays an important role against immune system deficiencies, cardiovascular disease [137], prenatal health problems, eye disease, and skin wrinkling. Vitamin C works as an antioxidant and can prevent scurvy, lead toxicity, and cancer [138].
Vitamin D is a combination of calciferol (
Vitamin E has several forms and the human body can use only alpha-tocopherol form. Good sources of vitamin E are plant-based oil (e.g. sunflower, soya, corn, and olive oil), nuts, seeds, fruits, and vegetables. The potential health benefits are moisturizing skin, wound healing, preventing cancer [139], reducing skin itching and eczema, psoriasis, preventing and minimizing the appearance of scars, uses for treatment of wrinkles, preventing sunburn, promoting nail health and enhance immune response [140]. Vitamin E is also used for the treatment of diabetes and dementia [141].
Vitamin K is a group of compounds and of them, the main are vitamin K1 and vitamin K2. The main sources of vitamin K1 are leafy greens vegetables and other vegetables (brussels sprouts, broccoli, cauliflower, and cabbage). However, sources of vitamin K2 are meats, fish, liver, cheeses, and eggs. Vitamin K plays an important role to prevent osteoporosis [142], vascular calcification [143], and cardiovascular disease. Besides these, it has other health benefit roles, such as bone health, cognitive health, and heart health.
Minerals are inorganic elements present in the soil and water and are important for the body to stay healthy. According to the human body demands, dietary minerals are two types, such as macro-minerals those are required in large amounts (e.g. calcium, phosphorus, magnesium, sodium, potassium, and sulfur), and micro- or trace-minerals those are required very small amounts (e.g. chromium, copper, cobalt, iron, fluorine, manganese, iodine, molybdenum, zinc, and selenium) [144].
Calcium is a nutrient that all living organisms need and it is the most common mineral in the human body.
The main sources of calcium are milk, cheese, yogurt and other dairy products, green leafy vegetables (curly kale and okra), soya drinks with added calcium, and bread made with fortified flowers.
Magnesium is one of the most important macro-nutrients for the human body.
Main sources of magnesium are avocados, legumes, nuts, seeds, tofu, whole grains, some fatty fish, dark chocolate, bananas, and leafy greens.
Magnesium plays an important role in bone health and cardiovascular health, prevents diabetes and migraine headaches [147], premenstrual syndrome, and anxiety.
Potassium is an important and necessary nutrient for the human body.
Potassium-rich foods are bananas, oranges, cantaloupe, honeydew, apricots, grapefruit, dried fruits, such as prunes, raisins and dates, cooked spinach and broccoli, potatoes, sweet potatoes, mushrooms, peas, cucumbers, and seafood. Milk, meat, yogurt, and nuts are also good sources of potassium.
An adequate amount of potassium intake may prevent high blood pressure [148] that may reduce cardiovascular disease and stroke [149]. People who eat potassium-containing fruits and vegetables may have higher bone mineral density and it also helps to preserve muscle mass. High potassium may help kidneys’ ability to reabsorb calcium and reduce kidney stones [150].
Chromium is an essential trace element that the human body needs in very small quantities to properly maintain some health functions.
The good sources of chromium are grape juice, whole wheat flour, brewer’s yeast, orange juice, beef, tomato juice, apples, and green beans.
Some important health benefits of chromium are it may be helpful for type II diabetic patients. It can decrease glucose levels and improve insulin sensitivity. Chromium supplements can be used to build muscle or trigger weight loss. Some side effects including watery stool, vertigo, headaches, and hives are reported for taking chromium supplements.
Copper is required in small quantities but it is an essential nutrient for the body.
Main sources of copper are organ meats (liver and kidneys), oysters, spirulina, shiitake mushrooms, nuts and seeds, lobster, dark leafy greens, whole grains, dried fruits (prunes, cocoa, and black pepper), and dark chocolate.
Copper helps to produce red blood cells, regulates heart rate and blood pressure, the absorption of iron, prevents inflammation of the prostate, in development and maintenance of bone, brain, and heart, and activates the immune system [151].
Iodine is an essential trace element and is required for the human body.
The important sources of iodine are fish (cod and tuna), shrimp, and other seafood. Dairy products (milk, yogurt, and cheese), eggs, prunes, lima beans, and iodized salt.
Iodine is essential for the synthesis of thyroid hormone that is required for metabolism. The deficiency of thyroid hormone is called hypothyroidism can lead to issues with fatigue, joint pain, and fertility problems. Iodine plays an important role in proper bone and brain development.
Iron deficiency is associated with several health impairments.
Good sources of iron are organ meats, red meat, turkey, shellfish, white beans, pumpkin seeds, quinoa, nuts, dark chocolate, dried fruits, soybean flour, lentils, tofu, sardines, spinach, broccoli, cooked oysters, and fortified breakfast cereals.
Iron is helpful for the treatment of anemia; it may reduce fatigue and improves muscle endurance. It has an important role in strengthening the immunity system. Iron improves cognitive function [152] and reduces bruising.
Selenium is an important macromineral and essential for the human body. Selenium deficiency is common in a certain part of the world as it can be affected by pH.
The sources of selenium are Brazil nuts, fish, ham, enriched foods, pork, beef, turkey, chicken, cottage cheese, eggs, brown rice, sunflower seeds, baked beans, mushrooms, oatmeal, spinach, milk and yogurt, lentils, cashews, and bananas.
Selenium has several health benefits, such as acts as a powerful antioxidant, may reduce the risk of certain cancers-lung [153], prostate [154], liver, colon [155], esophageal, and gastric [156]. It may protect against heart disease and prevents mental decline. Selenium is important for maintaining thyroid health, helping to boost the immune system, and reducing asthma symptoms.
Zinc is a vital and second-most-abundant and essential mineral for the human body.
The best sources of zinc are meat, shellfish, legumes, hemp seeds, nuts, dairy, eggs, whole grains, some vegetables, and dark chocolate.
Zinc is important for various functions in the body, such as helps to increase the immune system, uses in treating diarrhea, wound healing, works as an antioxidant and reduces chronic diseases, prevents age-related macular degeneration [157], improves sexual health, prevents osteoporosis, reduces neurological symptoms, protects from the common cold, boosts cognitive function, and increase learning and memory.
Functional food components are important compounds available in a variety of fruits, vegetables, and some animal products. They are also manufactured commercially. They have several health benefits for the human body. Many functional food components are antioxidants rich and help to neutralize free radicals, prevent cell damage, and reduce non-communicable diseases, such as cancer, diabetes, heart diseases and maintain health properly. To optimize health benefits and bioavailability of functional food components in the human body are critical factors. To maintain the levels required in the human body need an adequate amount of these components. Recent information in this regard is not sufficient. Therefore, need to provide more information to consumers to guide them effectively so that they can choose diets that contain adequate levels of health-promoting functional food components.
The author declares that there is no conflict of interest.
None.
Corrosive ingestion is a medical emergency that is especially prevalent in developing countries such as Thailand [1, 2, 3, 4, 5, 6, 7, 8, 9]. Since 2020, the COVID-19 has had an enormous impact on many sectors worldwide, and it had affected the trend of rising incidence and severity of diseases [10]. However, the actual incidence should not be precise as the tip of the iceberg phenomenon is probably under-report [4, 8]. Currently, various studies on this topic are still being developed for medical knowledge to the achievement goal of the best practice. Perforation and stricture are complications of corrosive ingestion which are currently being researched and which are discussed in this chapter.
Caustic injuries are caused by the ingestion of substances with acid or base properties. Acids cause coagulation necrosis, and alkalis cause liquefaction necrosis. Corrosive ingestion in children is usually accidental. In adults, it might be related to suicide. Therefore, it is a public health concern with mental and socioeconomic aspects [1, 2, 6, 11].
Morbidity with mortality rates of corrosive injuries are high [12, 13]. Airway assessment and prompt management are priorities in emergency settings, especially in severe cases [2, 13, 14]. Extensive burns can cause the fragile esophageal wall to become perforated. Physicians must evaluate this condition as soon as possible. Stricture is another complication that physicians need to evaluate. Post-corrosive esophageal strictures cause patients to suffer and are difficult to treat [2, 3, 4, 9, 12, 15, 16, 17, 18, 19].
Caustic substances with pH less than two or more than 12 are especially destructive. Form, concentration, amount of ingestion, and contact duration also affect the results. Acidic substances generate coagulation necrosis which creates eschar formation. Eschar can limit the penetration of injuries [16]. On the other hand, alkaline substances melt the tissue protein and initiate liquefactive necrosis with saponification that can penetrate deeper into the esophageal wall [17].
Perforation occurs in the acute stage of severe esophageal injuries. As a consequence of perforation, stricture follows during the recovery stage. Tissue injuries after corrosive ingestion go through three phases. Phase 1 is characterized by cell necrosis and thrombosis, 48–72 hours after the event. Next, in Phase 2, there is mucosal sloughing with ulceration of the esophageal wall plus fibroblast colonization and granulation. This phase continues for 14 days from the Phase 1, and the esophagus is friable during this phase. Finally, in Phase 3, the healing process starts in the third week and usually continues 3–6 months [3, 20, 21].
When patients arrive at the emergency department, stabilization of the patient is the most important target for this stage [21]. Signs and symptoms that often occur in corrosive ingested patients include burning of the oral cavity, drooling, nausea, and vomiting. Upper gastrointestinal bleeding can be found in severe cases, indicating substance injuries to the alimentary tract. Respiratory trauma can result in hoarseness, difficulty to breathe, stridor, and airway compromise. Esophagus perforation can be expressed as mediastinitis, chest wall emphysema, and pneumothorax, depending on time and severity.
Physicians should first examine the airway, especially for signs of aspiration or laryngeal injury. Physical examination and history taking should be done for details of the corrosive substance, the volume, timing before admission, pre-hospital treatment, and cause of ingestion. The patient should be given nil per os (NPO) and adequate resuscitation. Nasogastric tube intubation, gastric lavage, administration of emetic drugs, and neutralizing agents are not recommended because reflux of these agents into the esophagus could result in further damage [1, 8, 21]. Intravenous broad-spectrum antibiotics may benefit a patient with high-grade esophageal injuries. The investigation by chest and abdominal radiography should be evaluated. In cases of attempted suicide, the patient should be evaluated by the psychiatric department [1, 3, 4, 9, 22, 23].
The initial evaluation of the severity of a caustic injury provides important information. Esophagogastroduodenoscopy (EGD) is recommended for grading esophageal injuries following the Zargar classification (Table 1). Zargar classification can assist prognosis and guide clinical management [16]. The EGD should be done as soon as possible within 24–48 hours. Performing endoscopy after 48 hours is not recommended because the tissue injuries go through Phase 2 when they should not be subjected to an unwanted event [16, 21]. For patients with Zargar grade 1 and 2a, an oral diet may be given. Patients with Zargar grade 2b and 3a can start an oral diet once they can swallow saliva. Esophagectomy should be performed on patients with Zargar grade 3b injuries.
Zargar classification | Description |
---|---|
Grade 0 | Normal finding on endoscopic examination |
Grade 1 | Edema and hyperemia of the mucosa |
Grade 2a | Friability, blisters, exudates, hemorrhages, whitish membrane, erosions, and superficial ulceration |
Grade 2b | Grade 2a plus deep discrete or circumferential ulceration |
Grade 3a | Small scattered areas of multiple ulceration and areas of necrosis with brown-black or grayish discoloration |
Grade 3b | Extensive necrosis |
Zargar classification of corrosive esophageal injury.
The method for assessing the degree of esophageal damage by computed tomography (CT) with scoring was recently established as a noninvasive modality [24]. Nowadays, the use of CT scans of the chest and abdomen is increasing. CT can assist prognosis after ingestion, but it is still inconclusive [25, 26, 27]. CT also provides extraesophageal information regarding anatomies such as the mediastinum, lung, and pleural cavity, which endoscopies do not (Table 2).
Score | Endoscopic score [16] | Computerized tomography score [24] |
---|---|---|
0 | Grade 0; Normal | Normal |
I | Grade 1; Edema and hyperemia of the mucosa | No definite swelling of esophagus wall (<3 mm, within normal limit) |
II | Grade 2a; Friability, blisters, exudates, hemorrhages, whitish membrane, erosion, and superficial ulceration | Edematous wall thickening (>3 mm) without periesophageal soft tissue infiltration |
Grade 2b; Grade 2a plus deep discrete or circumferential ulceration | ||
III | Grade 3a; Small scattered areas of multiple ulceration and areas of necrosis with brown-black or grayish discoloration | Edematous wall thickening with periesophageal soft tissue infiltration pulse well-demarcated tissue interface |
Grade 3b; Extensive necrosis | ||
VI | Grade 4; Perforation | Edematous wall thickening with periesophageal soft tissue infiltration plus blurring of tissue interface or localized fluid collection around the esophagus or the descending aorta |
Endoscopic score and computerized tomography score of corrosive esophageal injury.
Although an endoscopy is an important tool for initial evaluation, contraindications are suspected perforation, oral cavity necrosis, and airway injury with compromised respiration. CT scans can safely provide details about esophageal transmural necrosis consisting of esophageal wall blurring, peri-esophageal fat stranding, and no enhancement of esophageal wall after administration of intravenous contrast [24]. Recent studies reported that unnecessary esophagectomy following endoscopic evaluation of patients with Zargar grade 3b could have been avoided if CT had been used [28, 29, 30].
Both CT and endoscopy have distinctive advantages. CT is minimally invasive with high sensitivity and specificity [24, 25, 27, 28, 29, 30]. Intra-luminal evaluation by endoscopy reveals subtle details of the esophageal mucosa and degrees of damage [31]. The combination of CT and endoscopy is especially useful for examining patients with Zargar 3b injuries [8, 30, 31].
As the esophagus is healing following ingestion of a corrosive substance, the possibility of stricture should be assessed. Post-corrosive esophageal stricture is a complication that produces suffering for victims [9, 15, 17]. Esophageal dilation is a therapeutic intervention of choice to perform at the onset of stricture. If left until later, the procedure becomes more difficult, decreasing the success and increasing adverse events [21, 32, 33, 34, 35, 36]. Esophageal dilatation can be performed repeatedly according to schedule and using various dilators such as Maloney-Hurst, Savary-Gilliard, and Balloon dilator under the endoscopy, fluoroscopy, or both. Alternative methods for post-corrosive esophageal stricture such as esophageal stenting [21, 37, 38], intralesional steroids [21, 39, 40, 41, 42, 43], and, Mitomycin-C [21, 44, 45, 46, 47, 48] have been published with various outcomes. These options might supplement dilation with better results. In cases of severe stricture, failure to dilate, or refractory strictures, surgery might be necessary (Figure 1) [4, 18, 19, 49, 50, 51, 52, 53, 54].
The treatment options for post-corrosive esophageal stricture. (A) Severe post-corrosive esophageal stricture; (B) Savary-Gilliard dilator; (C) endoscopic balloon dilation; (D) esophagectomy with open right thoracotomy; (E) esophagectomy with video-assisted thoracoscopic surgery (VATS); (F) reconstruction with cervical anastomosis after esophagectomy; (G, H) right side colonic conduit for esophageal replacement; and (I) subcutaneous colon interposition.
Post-corrosive esophageal stricture should highly consider inpatient with Zargar grade 2b and 3a [4, 5, 8, 9, 16, 55]. Although various treatment strategies have been developed, none of them can provide outstanding results. Stricture prevention would be the ideal method. Corticosteroids reduce inflammation, but the benefit is inconclusive. Steroids cause severe adverse side effects such as esophageal candidiasis, gastric ulcer, ethmoiditis, osteomyelitis, and osteoporosis [56, 57, 58]. Recent studies have demonstrated that omeprazole with proton pump inhibitor activity could enhance healing, reduce stricture, and reduce the short-term risk of developing esophageal stricture in patients with 2b and 3a corrosive injuries [9, 59, 60, 61]. However, further studies of omeprazole are needed to corroborate these findings (Figure 2).
Schematic diagram of corrosive ingestion in esophageal injury.
Corrosive ingestion is a serious medical emergency that is a global problem, especially in several developing countries. When patients arrive at the emergency department, stabilization of the patient is initially the most important target. Airway assessment and prompt management are the priorities for emergency settings, especially in severe cases. Any intervention that might cause substance reflux into the esophagus resulting in further damage is not recommended. Current methods for assessing the degree of esophageal damage are early endoscopy for Zargar classification and CT scan, which focuses on ruling out perforation. Post-corrosive esophageal stricture can be a consequent complication with poor treatment outcomes, and stricture prevention is an interesting idea.
The author declares no conflict of interest.
Special thanks to Michael Jan Everts for assistance in editing the English version of this chapter.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Therefore, more studies are needed to assess the benefit of antibiotic prescription and whether it is safe to refrain from its use.",book:{id:"5185",slug:"dental-implantology-and-biomaterial",title:"Dental Implantology and Biomaterial",fullTitle:"Dental Implantology and Biomaterial"},signatures:"Dalia Khalil, Bodil Lund and Margareta Hultin",authors:[{id:"179031",title:"Dr.",name:"Dalia",middleName:null,surname:"Khalil",slug:"dalia-khalil",fullName:"Dalia Khalil"},{id:"185113",title:"Dr.",name:"Bodil",middleName:null,surname:"Lund",slug:"bodil-lund",fullName:"Bodil Lund"},{id:"185114",title:"Dr.",name:"Margareta",middleName:null,surname:"Hultin",slug:"margareta-hultin",fullName:"Margareta Hultin"}]},{id:"47915",title:"Rationale for Dental Implants",slug:"rationale-for-dental-implants",totalDownloads:3076,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"4548",slug:"current-concepts-in-dental-implantology",title:"Current Concepts in Dental Implantology",fullTitle:"Current Concepts in Dental Implantology"},signatures:"Ilser Turkyilmaz and Gokce Soganci",authors:[{id:"171984",title:"Associate Prof.",name:"Ilser",middleName:null,surname:"Turkyilmaz",slug:"ilser-turkyilmaz",fullName:"Ilser Turkyilmaz"}]},{id:"18430",title:"An Important Dilemma in Treatment Planning: Implant or Endodontic Therapy?",slug:"an-important-dilemma-in-treatment-planning-implant-or-endodontic-therapy-",totalDownloads:6264,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Funda Kont Cobankara and Sema Belli",authors:[{id:"28846",title:"Dr.",name:"Funda",middleName:null,surname:"Kont Çobankara",slug:"funda-kont-cobankara",fullName:"Funda Kont Çobankara"},{id:"75862",title:"Prof.",name:"Sema",middleName:null,surname:"Belli",slug:"sema-belli",fullName:"Sema Belli"}]}],onlineFirstChaptersFilter:{topicId:"998",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81595",title:"Prosthetic Concepts in Dental Implantology",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.104725",abstract:"This chapter will address evidence-based prosthetic concepts in dental implantology as well as clinical evidence with focus on appropriate logic and technical skills. Those prosthetic factors are as just important as surgical factors, and long-term success can only be achieved if both of those factors are considered, respected, and strictly followed from planning to prosthetic phase of treatment. This chapter will deal with materials selection for prosthetic part, shape, size, and design of supracrestal parts of abutments and their influence on soft tissue and bone stability around dental implants. Furthermore, one of most important decisions is about choosing the proper way of retention: screw- vs. cement-retained restorations, and it will be discussed in detail. Additionally, emergence profile and its function in soft tissues adaptation and adhesion to different prosthetic materials also have important role in long-term success of dental implant restorations.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Ivica Pelivan"},{id:"80500",title:"Novel Dental Implants with Herbal Composites: A Review",slug:"novel-dental-implants-with-herbal-composites-a-review",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.101489",abstract:"Missing a permanent tooth is a miserable condition faced by a common man. A tooth decay, periodontitis, mechanical trauma, or any systemic complications lead to such a complication. These bone defects when left untreated lead to severe resorption of the alveolar bone. A proper dental filling with an appropriate bone substitute material could prevent such resorption and paves a way for subsequent implant placement. Dental implants are considered as the prime option by dentists to replace a single tooth or prevent bone resorption. A variety of bone substitutes are available differ in origin, consistency, particle size, porosity, and resorption characteristics. Herbal composites in dentistry fabricated using biphospho-calcium phosphate, casein, chitosan, and certain herbal extracts of Cassia occidentalis, Terminalia arjuna bark, Myristica fragans also were reported to possess a higher ossification property, osteogenic property and were able to repair bone defects. C. occidentalis was reported to stimulate mineralization of the bone and osteoblastic differentiation through the activation of the PI3K-Akt/MAPKs pathway in MC3T3-E1 cells of mice. This implant proved better osteoconductivity and bioactivity compared to pure HAP and other BCP ratios. Terminalia Arjuna was also worked in the incorporation in the graft to enhance the osteogenic property of the implant and gave good results. Another implant bone graft was synthesized containing BCP, biocompatible casein, and the extracts of Myristica fragans and subjected to in vitro investigations and the results revealed the deposition of apatite on the graft after immersing in SBF and also the ALP activity was high when treated with MG-63 cells, NIH-3 T3, and Saos 2 cell lines. This study indicates that the inclusion of plant extract enhances the osteogenic property of the graft. Thus, these novel dental implants incorporated with herbal composites evaluated by researchers revealed an enhanced bone healing, accelerates osseointegration, inhibits osteopenia, and inhibits inflammation. This application of herbal composite inclusion in dentistry and its applications has a greater potential to improve the success rate of dental implants and allows the implications of biotechnology in implant dentistry.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Gopathy Sridevi and Seshadri Srividya"},{id:"78320",title:"Implant-Retained Maxillary and Mandibular Overdentures - A Solution for Completely Edentulous Patients",slug:"implant-retained-maxillary-and-mandibular-overdentures-a-solution-for-completely-edentulous-patients",totalDownloads:66,totalDimensionsCites:0,doi:"10.5772/intechopen.99575",abstract:"The main goal of modern removable prosthodontics is to restore the normal appearance, function, esthetics and speech in each completely edentulous patient. However, if all teeth are missing in a patient, it becomes very complicated to achieve it using traditional protocols. Therefore, implants were introduced into removable prosthodontics to ensure better retention and stability of the conventional dentures. In case of a large amount of bone missing in the jaw it is necessary to ensure the functioning of the dentures constructing various additional stabilizing and retentive prosthodontic solutions on the osseointegrated implants. Numerous types of attachment systems have been used recently for relating implant-retained overdentures to underlying implants: basically splinting (various bar shape designs) and non-splinting attachments (various ball type attachment, magnet attachment, telescopic coping systems). Indications for their use depend on the surgical and prosthodontic factors such as the number and position of the implants, the amount of free intermaxillary space and the type and size of the overdentures. Different indications, types of the overdentures and the attachment systems will be discussed in this chapter.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Dubravka Knezović Zlatarić, Robert Ćelić and Hrvoje Pezo"},{id:"79724",title:"Implant Stability Quotient (ISQ): A Reliable Guide for Implant Treatment",slug:"implant-stability-quotient-isq-a-reliable-guide-for-implant-treatment",totalDownloads:60,totalDimensionsCites:0,doi:"10.5772/intechopen.101359",abstract:"Implant stability is a prerequisite for successful dental implants and osseointegration. To determine the status of implant stability, continuous monitoring in an objective and qualitative manner is important. To measure implant stability two different stages are there: Primary and secondary. Primary implant stability at placement is a mechanical phenomenon that is related to the local bone quality and quantity, the type of implant and placement technique used. Primary stability is checked from mechanical engagement with cortical bone. Secondary stability is developed from regeneration and remodeling of the bone and tissue around the implant after insertion and affected by the primary stability, bone formation and remodeling. Implant stability is essential for the time of functional loading. Classical benchmark methods to measure implant stability were radiographs or microscopic analysis, removal torque, push-through and pull-through but due to lack of feasibility, time consumption and ethical reasons other methods have been propounded over period of time like measurement of implant torque, model analysis and most important ISQ which has the ability to monitor osseointegration and the life expectancy of an implant. ISQ is a valuable diagnostic and clinical tool that has far-reaching consequences on implant dentistry and this article throws light on advanced and reliable methods of assessing ISQ.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Gaurav Gupta"},{id:"79817",title:"Peri-Implant Soft Tissue Augmentation",slug:"peri-implant-soft-tissue-augmentation",totalDownloads:128,totalDimensionsCites:0,doi:"10.5772/intechopen.101336",abstract:"The peri-implant soft tissue (PIS) augmentation procedure has become an integral part of implant-prosthetic rehabilitation. Minimal width of keratinized mucosa (KM) of 2 mm is deemed necessary to facilitate oral hygiene maintenance around the implant and provide hard and soft peri-implant tissue stability. PIS thickness of at least 2 mm is recommended to achieve the esthetic appearance and prevent recessions around implant prosthetic rehabilitation. The autogenous soft tissue grafts can be divided into two groups based on their histological composition—free gingival graft (FGG) and connective tissue graft (CTG). FGG graft is used mainly to increase the width of keratinized mucosa while CTG augment the thickness of PIS. Both grafts are harvested from the same anatomical region—the palate. Alternatively, they can be harvested from the maxillary tuberosity. Soft tissue grafts can be also harvested as pedicle grafts, in case when the soft tissue graft remains attached to the donor site by one side preserving the blood supply from the donor region. Clinically this will result in less shrinkage of the graft postoperatively, improving the outcome of the augmentation procedure. To bypass the drawback connected with FGG or CTG harvesting, substitutional soft tissue grafts have been developed.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Marko Blašković and Dorotea Blašković"},{id:"79611",title:"Growth Factors and Dental Implantology",slug:"growth-factors-and-dental-implantology",totalDownloads:103,totalDimensionsCites:0,doi:"10.5772/intechopen.101082",abstract:"Normal healing procedure of bone involves various sequential events to develop bone and bridge the bone -to- bone gap. When this healing occurs with a metal (titanium) fixture on one side, it is called as osseointegration. After extensive studies on this topic, it is found that this procedure occurs in presence of various biologic constituents that are spontaneously released at the site. Thus, to accelerate normal healing after implant placement and make results more predictable, it has been proposed to use these autologous factors in the osteotomy site. Since it is the beginning of a new revolution in dental implantology, right now it is essential to analyze all possible combinations of host conditions, bone quality and quantity and bio factors being used. This can definitely be a boon for the patients with compromised systemic or local conditions.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Deeksha Gupta"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. 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His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:10,paginationItems:[{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}},{id:"82367",title:"Spatial Variation and Factors Associated with Unsuppressed HIV Viral Load among Women in an HIV Hyperendemic Area of KwaZulu-Natal, South Africa",doi:"10.5772/intechopen.105547",signatures:"Adenike O. 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He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Animals need to receive a properly balanced diet. One of the new challenges we are now faced with is sustainable animal diets (STAND) that involve the 3 P’s (People, Planet, and Profitability). We must develop animal feed that does not compete with human food, use antibiotics, and explore new growth promoters options, such as plant extracts or compounds that promote feed efficiency (e.g., monensin, oils, enzymes, probiotics). 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