Visual Discrimination Threshold
\r\n\tThis book will mainly cover work related to: (i) cells mechanosensing and mechanotransduction mechanisms (ii) computational and experimental techniques in mechanobiology, (iii) mathematical mechanobiological models of bone remodeling, (iv) bone mechano-transduction, (v) innovative tools for mechanobiology and the role of medical imaging in this field and (vi) any other proposals related to innovations, clinical application and perspectives of mechanobiology.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"0a38ccecc83b50d8b015a6dd2533049d",bookSignature:"Prof. Abdelwahed Barkaoui",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10255.jpg",keywords:"Nuclear Mechanotransduction, Mechanosensitivity, Fluids Mechanics, Multiscale Mechanobiology, Modeling Cellular Mechanics, Finite Elements Method, Bone Remodeling, Mechanics Stimulus, Multi-scale Modeling, Mechanobiology Tools, Cell Imaging, Cell-Substrate Interactions",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 2nd 2020",dateEndSecondStepPublish:"July 23rd 2020",dateEndThirdStepPublish:"September 21st 2020",dateEndFourthStepPublish:"December 10th 2020",dateEndFifthStepPublish:"February 8th 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Assistant director of LERMA laboratory, head of mechanical discipline at ECINE and coordinator of the ECINE study program accreditation committee, a member of the editorial board of several international scientific journals, also a member of the American Society of Mechanical (ASME) Engineers European Society of Biomechanics (ESB) and the International Society of Biomechanics (ISB).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"320631",title:"Dr.",name:"Abdelwahed",middleName:null,surname:"Barkaoui",slug:"abdelwahed-barkaoui",fullName:"Abdelwahed Barkaoui",profilePictureURL:"https://mts.intechopen.com/storage/users/320631/images/system/320631.jpg",biography:"Abdelwahed BARKAOUI is an Associate Professor of Mechanical Engineering at the International University of Rabat. He obtained his University habilitation from the University of Tunis El Manar-Tunisia in 2017 and his Ph.D. from the University of Orleans, France in 2012. He has a master\\'s degree in mechanics obtained from the INSA of Lyon, France, and an engineering diploma in electromechanics from ENI-Sfax, Tunisia. Currently, dr. BARKAOUI is the assistant director of the LERMA laboratory and coordinator of the Modelling & Simulation in Biomechanics & Biomaterials (MS2B) team. He is responsible for the mechanical discipline and coordinator of the ABET accreditation project at the Higher School of Energy Engineering. His research is focused on biomechanics, mechanobiology, and biomedical engineering. He was a member of the editorial board of several international scientific journals such as Frontiers in Bioengineering and Biotechnology “Biomechanics” (IF=5,9), BMC Musculoskeletal Disorders (IF:2.6), BMC Biomedical Engineering, Series on Biomechanics, as well as a reviewer for several international journals\nin the field of biomechanics and mechanical engineering. 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Especially, we focus on the discrepancy between the two stimuli.
\n\t\t\tWhen making a purchase from TV or online, we are sometimes disappointed by a product whose actual scale and material differ from our image, even though its appearance originally impressed us. This case indicates the use of integrated multiple sensory cues that include not only the visual but also the auditory and haptic to extract the properties of objects. However, the fusion of multiple sensory cues by interaction with each other has not been well examined. We introduce our developed system that can independently control the sensibility parameters of visual and haptic cues to study the effect of these cues on sensory properties.
\n\t\t\tMR techniques have been applied in factories to assist assembly, inspection and maintenance operations (Ohta & Tamura, 1999) (Wiedenmaier, et al, 2001) (Friedrich, 2002) (Fiorentino et al, 2002) (Nolle & Klinker, 2006). Recently, designing operations for industrial products are gathering attention as the next generation of MR applications (Navab, 2003) (Lee & Park, 2005) (Sandor et al, 2007). In ordinary designing operations, first, designers develop a broad plot of shape, appearance, and inner structure using a Computer Aided Design (CAD) system. After that, a mock-up, which is a dummy model of the designing product, is generated to examine such detailed information as a sense of touch and surface texture that is difficult to represent by CAD. However, generating a mock-up is very expensive, especially since it uses temporal resources. Thus, it is not practical to regenerate a mock-up whenever a design receives a minor change.
\n\t\t\tThe display system shown in Figure 1 might create a new style of product design to reduce operation processes. For example, in ordinary product design, when a designer wants to evaluate different impressions caused by subtle changes of surface material, many similar preproduction samples must be generated that correspond to each change. However, design variations are usually limited because they are too expensive. On the other hand, using our proposed system, evaluation is possible by superimposing computer graphics (CG) textures of various appearances onto a design mock-up that solves not only cost problems but also the limitations of trial design variations.
\n\t\t\tTo realize such a design support system, it is important to investigate how visual and haptic sensory sources are fused and affect each other.
\n\t\t\tExample of Designing Operation for Industrial Products by Using Mixed Reality. By using this system, evaluation is possible by superimposing computer graphics (CG) textures of various appearances onto a design mock-up that solves not only cost problems but also the limitations of trial design variations.
Visual cues seem to affect to estimate environmental properties. As a result, some research reports that haptic cues are affected by visual cues. Several studies have addressed this issue in the real world (Biocca et al, 2001) (Adams et al, 2001) (Rock & Harris, 1967) (Rock & Victor, 1964) (Lederman, & Abbott, 1981) (Hillis et al, 2002). In these researches, however, since subjects could not see an object, they had to imagine that they were grasping what they were looking at. The evaluating saturation is nowhere near the touching/holding operation in daily life, on the other hand, looking at and touching an object is important for evaluation. By focusing on such inconveniences, we developed a system that provides various impressions of an observed object by showing different visual information from the actual shape and material using an MR technique (Nakahara et al, 2007). Wang et al. also developed a MR system that fuses visual and haptic information (Wang et al, 2000). However, when the system developed, the quality of CG technology was not powerful to express subtle difference of appearance caused by changes of surface material. Then, the purpose of the investigation about sensory properties in fusion of visual/haptic stimuli is different from ours. Figure 2 shows an overview of our proposed system. A user perceives a tactile sensation by touching a real object. By displaying the object’s appearance, the tactile sensation is merged with the visual sensation in the user’s perception.
\n\t\t\tAs a procedure to analyze sensory properties, we focus on two features of objects. One is the impression of texture that is intimately involved in the impression of products. The other is the sharpness of a cube’s edge, which is strongly affected by both visual and haptic senses. Below we introduce two experiments that evaluate the impression of texture and the sensation of sharpness by using our MR system.
\n\t\t\tFusion of Visual/Haptic Cues Using Mixed Reality. A user perceives a tactile sensation by touching a real object. By displaying the object’s appearance, the tactile sensation is merged with the visual sensation in the user’s perception.
We assume the impression of texture consists on two kinds: haptic and visual. Haptic texture is a stimulus given by the tactile sensation of touching an object, and visual texture is a stimulus given by its appearance. When touching glass material with closed eyes, we experience a tactile sensation that resembles the impres-sion of a “glass haptic texture.” When looking at a glass material without touching, we experience a visual sensation that resembles an impression of a “glass visual texture.” This section introduces our experimental evaluation that investigates whether it is possible to control the impression of a haptic texture by changing visual textures.
\n\t\t\tAs shown in Figure 3, the experimental system can overlap various visual textures generated by computer graphics onto a real object. In this system, real objects are several plates made from different materials. We choose stone, cork, unglazed tile, steel, and wood as the materials of the plates. The stone has a rough surface, but it is not polished. When a subject strongly pushes the cork with a finger tip, its shape is deformed. The unglazed tile has a rough surface, but it is not cover coated. The surfaces of the steel and wood are smoothed by filing. An example of a subject’s view is shown in Figure 4. An overlapping texture covers the entire real object.
\n\t\t\t\t\n\t\t\t\t\tFigure 5 shows an experimental scene. First, after we measure the temperature of a subject’s hand, he/she puts on a thin latex glove. From pilot studies, we learned that haptic stimulus affects the texture impression more strongly than the visual stimulus. So we use a glove that deadens the haptic sensation to maintain balance.
\n\t\t\t\tSince humans can identify material by sensing inherent specific heat of each object, we maintained the temperature of the real objects at the temperature of a subject’s hand by using a thermos-tatically-controlled electric carpet.
\n\t\t\t\tTo maintain photometric consistency between real and virtual appearances, the system maps actual images captured by a high-end single-lens reflex camera at an identical position as a subject’s viewpoint. We use a high-definition HMD that can display a 1280×1024 image to increase the evaluation reality as much as possible. If a subject’s viewpoint differs from the viewpoints of other subjects, geometric and photometric inconsistencies are created between the visual cues. Subjects were instructed to fix their jaw at a prescribed position while they looked at a CG texture in the middle of an HMD, as shown in Figure 4.
\n\t\t\t\tThese considerations described above allow evaluation of the impression of texture by only deriving visual and haptic stimuli.
\n\t\t\t\tSubjective Evaluation of Texture Impression. The experimental system can overlap various visual textures generated by computer graphics onto a real object.
Example of a Subject’s View. An overlapping texture covers the entire real object.
An Experimental Scene of Evaluation. We use a glove that deadens the haptic sensation to maintain balance of haptic and visual stimuli.
As shown in the picture on the left of Figure 6, when a subject moves a hand over a real object, the hand is occluded by the CG texture. As a result, subjects have difficulty feeling as they are actually touching a real object. We solve this problem by a skin color matting technique (Itoh et al, 2003) that utilizes a property that clusters the skin region in the chroma space. We defined a skin color model in chroma space in advance and segment the skin color region from captured images using the model. As shown in the picture on the right of Figure 6, generating an image is possible that does not spoil the appearance of the user’s hand.
\n\t\t\tExample of Occlusion: (Left) subject’s finger region is occluded by CG; (Right) occlusion problem in finger region is solved.
We evaluated the amount of mistaken sensations caused by the combinations of haptic and visual textures. Since each texture has five types of materials (stone, cork, unglazed tile, steel, and wood), there are 25 combinations. We analyzed texture impressions examining evaluation score which are answered by all subjects for all combinations. In all trials, subjects were permitted to take as much time as needed. The displayed textures are randomly chosen to control for order effects.
\n\t\t\t\tThe subjective evaluations were conducted by ten male subjects in their 20s who were presented a randomly selected combination of haptic and virtual textures and then were answered whether their impressions matched the material they saw. A five-level rating scale was used. Scale 1 means “completely different impression from what I see.” Scale 2 means a “different impression.” Scale 3 means “No difference” Scale 4 means “almost identical impression what I see.” Scale 5 means “completely identical.” When the subject gives a high score with observing an MR object which has inconsistent visual and haptic texture, it shows that the visual cue has stronger influence than the haptic one for the impression of the object’s texture.
\n\t\t\t\n\t\t\t\t\tFigure 7 shows the evaluation results. The horizontal axis represents the kinds of materials, and the vertical axis represents the mean evaluating rate for each material. The line with rhombus nodes indicates the result of displaying the visual texture of stone. The line with box nodes indicates the result of displaying the visual texture of cork. The line with triangle nodes indicates the result of displaying the visual texture of unglazed tile. The line with X nodes indicates the result of displaying the visual texture of steel. The line with asterisk nodes indicates the result of displaying the visual texture of unglazed wood.
\n\t\t\t\tWhen we used a cork plate as a real object, few subjects had a different impression from the real material when the visual texture is changed. Based on the questionnaire data, subjects identified the material by its surface softness. When we used a wood plate as a real object, some subjects commented that they could feel the surface softness. As a result, it was difficult to give an impression as if touching other materials.
\n\t\t\t\tNote that the evaluation rates of the haptic-stone/visual-steel and haptic-steel/visual-stone combinations are high, even though the haptic textures of their surfaces are quite different. In the questionnaire data, when touching a stone plate with a rough surface while looking at a visual texture of steel, one subject had the impression of touching a steel plate that was not well polished. On the other hand, when touching a steel-plate with a smooth surface while looking at the visual texture of stone, one subject had the impression of touching a well polished stone plate, such as granite or marble. From this result, we assume that if we already had some different impressions (e.g., smooth or rough) about touching materials from past experience, controlling the impression of the real object between the impressions is possible by changing the visual texture. The assumption can be assessed by comparing the rough surfaces of stone and unglazed tile. Because we rarely have impression that the surface of unglazed tile is smooth in daily life, when we use a smooth steel plate as a real object and overlap an unglazed tile texture onto the plate, few subjects had the impression that they were touching an unglazed tile.
\n\t\t\t\tA Result of Subjective Evaluations for Texture Impression. The line with rhombus nodes indicates the result of displaying the visual texture of stone. The line with box nodes indicates the result of cork texture. The line with triangle nodes indicates the result of unglazed tile texture. The line with X nodes indicates the result of steel texture. The line with asterisk nodes indicates the result of unglazed wood texture.
We conducted an experimental survey to investigate whether an edge is perceived sharper than its actual curvature (4 mm) by overlapping a sharper appearance (1 mm) on the surface. Figure 8 shows an overview of this experiment. In this experiment, we quantify the haptic stimulus by curvature radius of the edges of cubes.
\n\t\t\tOverview of Subjective Evaluation of Sharpness Sensation. We conducted an experimental survey to investigate whether an edge is perceived sharper than its actual curvature (4 mm) by overlapping a sharper appearance (1 mm) on the surface.
\n\t\t\t\t\tFigure 9 shows a picture of an experimental scene. The subject maintains his viewpoint while putting his jaw at a predefined position to preserve geometric and photometric consistency between the real and virtual information. As illustrated in Figure 10, the distance between the subject’s viewpoint and a target object is about 30 cm and the tilt angle of the subject’s line of sight is 45 .
\n\t\t\t\tExperimental of Subjective Evaluation of Sharpness. The subject maintains his viewpoint while putting his jaw at a predefined position to preserve geometric and photometric consistency between the real and virtual information.
Positional Relationship between a Real Object and a Subject. The distance between the subject’s viewpoint and a target object is about 30 cm and the tilt angle of the subject’s line of sight is 45 .
We prepared three cubes with 10 cm sides to control haptic stimuli. One cube has 12 edges of curvature radius from 0.0 to 1.1 mm, one has edges from 1.2 to 2.3 mm, and another has edges from 2.4 to 3.5 mm. A cube is shown in Figure 11. It is possible to generate various CG appearances of the cube by controlling the curvature radii of the CG edges.
\n\t\t\t\tCube with 10 cm Sides to Control Haptic Stimuli. We prepared three cubes with 10 cm sides to control haptic stimuli. One cube has 12 edges of curvature radius from 0.0 to 1.1 mm, one has edges from 1.2 to 2.3 mm, and another has edges from 2.4 to 3.5 mm.
Angle Between Horizontal Plane and Virtual Light is 60 . This angle is almost the same as the environment light of the expe-rimental room.
Twelve male subjects in their 20s evaluated sharpness sensations by touching a CG overlapped cube that contained a discrepancy between vision and haptic stimuli.
\n\t\t\t\tAll subjects have visual acuity of nearsightedness over 1.0 to discriminate two lines with 0.14 mm interval which is generated by the sharpest edge in this research on an HMD.
\n\t\t\t\tA displayed virtual cube is illuminated by a point-source light. The angle between the horizontal plane and the light is 60 , as illustrated in Figure 12. This angle is almost the same as the environment light of the experimental room. By using ARToolKit (Kato & Billinghurst, 1999), the system overlaps the virtual cube onto a real cube. To prevent subjects from determining an edge’s sharpness by referring to a cut plane of the edge, the system does not display the cut plane, as shown in Figure 13. To solve the CG appearance problem, which involves overlapping of the subject’s hand in MR scenes, subject hands were extracted by using the same procedure described in Section 3.2.
\n\t\t\tExample of Displayed Image. To prevent subjects from determining an edge’s sharpness by referring to a cut plane of the edge, the system does not display the cut plane.
In the matching process, it is better that each stimulus value can be clearly defined by subjects. In other words, when we used too roughly quantized stimuli in the evaluation, evaluation precision suffers. On the other hand, when we used too finely quantized stimuli, subjects cannot define the differences. Therefore we quantize the scale of the curvature radii as a unit to present to subjects.
\n\t\t\t\tAs illustrated in Figure 14 physical stimulus differs from mental stimulus. We examined the discrimination thresholds of subjects by a psychology and statistics experiment. A discrimination threshold is the minimum distance at which subjects can define differences of stimuli.
\n\t\t\t\t\tA method of limits detects a discrimination threshold by examining if a subject can detect differences between two different stimuli while changing the gap step by step. In this experiment, we examined a discrimination threshold (human’s sensitivity) of sharpness by comparing reference stimulus R with standard stimulus R0. Reference stimulus R, which is the curvature radius of an edge, is changed at 0.1-mm intervals.
\n\t\t\t\t\tAs illustrated in Figure 15 when a subject felt reference stimulus R was sharper than standard stimulus R0, he recorded “-”. When a subject felt reference stimulus R was duller than standard stimulus R0, he recorded “+”. When discrimination was difficult, he recorded “?”. It is important to set an initial reference stimulus either large or small enough to easily define the difference between standard stimuli. We repeated the question-and-answer process until the subject recorded “?”. A discrimination threshold is defined as a region within marked “?” by operating the process both upward and downward. We conducted evaluations with twelve male subjects in their 20s, all of whom have visual acuity of nearsightedness over 1.0.
\n\t\t\t\t\tDifference between physical and mental stimulus
Definition for Mental Discrimination Threshold.
The estimated haptic and visual discrimination thresholds are shown in Table 1 and 2. Visual discrimination thresholds are defined at 0.4-mm interval, but haptic discrimination thresholds are not. In order to investigate how visual/haptic stimuli interact with each other, common criteria are necessary. We define the common criteria as the minimum perceivable seven steps for both of visual/haptic discrimination thresholds, 0.2, 0.6, 1.0, 1.4, 1.8, 2.2, and 2.6 mm. Although, humans can discriminate differences less than 0.1 mm, due to the limitations of the accuracy processing machinery, it is not possible to estimate haptic discrimination thresholds less than 0.1 mm.
\n\t\t\t\t\tBy considering different thresholds of visual and haptic information, we quantize the scale of the curvature radii into seven identical parts: 0.2, 0.6, 1.0, 1.4, 1.8, 2.2, and 2.6 mm.
\n\t\t\t\t\tStandard Stimulus (mm) | \n\t\t\t\t\t\t\t\tDiscrimination Threshold (mm) | \n\t\t\t\t\t\t\t\tStandard Deviation | \n\t\t\t\t\t\t\t
0.2 | \n\t\t\t\t\t\t\t\t0.332 | \n\t\t\t\t\t\t\t\t0.057 | \n\t\t\t\t\t\t\t
0.6 | \n\t\t\t\t\t\t\t\t0.382 | \n\t\t\t\t\t\t\t\t0.078 | \n\t\t\t\t\t\t\t
1.0 | \n\t\t\t\t\t\t\t\t0.395 | \n\t\t\t\t\t\t\t\t0.062 | \n\t\t\t\t\t\t\t
1.4 | \n\t\t\t\t\t\t\t\t0.322 | \n\t\t\t\t\t\t\t\t0.052 | \n\t\t\t\t\t\t\t
1.8 | \n\t\t\t\t\t\t\t\t0.338 | \n\t\t\t\t\t\t\t\t0.045 | \n\t\t\t\t\t\t\t
Visual Discrimination Threshold
Standard Stimulus (mm) | \n\t\t\t\t\t\t\t\tDiscrimination Threshold (mm) | \n\t\t\t\t\t\t\t\tStandard Deviation | \n\t\t\t\t\t\t\t
0.0 | \n\t\t\t\t\t\t\t\t0.000 | \n\t\t\t\t\t\t\t\t0.000 | \n\t\t\t\t\t\t\t
0.1 | \n\t\t\t\t\t\t\t\t0.000 | \n\t\t\t\t\t\t\t\t0.000 | \n\t\t\t\t\t\t\t
0.2 | \n\t\t\t\t\t\t\t\t0.130 | \n\t\t\t\t\t\t\t\t0.053 | \n\t\t\t\t\t\t\t
0.4 | \n\t\t\t\t\t\t\t\t0.270 | \n\t\t\t\t\t\t\t\t0.078 | \n\t\t\t\t\t\t\t
0.7 | \n\t\t\t\t\t\t\t\t0.238 | \n\t\t\t\t\t\t\t\t0.049 | \n\t\t\t\t\t\t\t
1.0 | \n\t\t\t\t\t\t\t\t0.237 | \n\t\t\t\t\t\t\t\t0.069 | \n\t\t\t\t\t\t\t
1.3 | \n\t\t\t\t\t\t\t\t0.300 | \n\t\t\t\t\t\t\t\t0.063 | \n\t\t\t\t\t\t\t
1.6 | \n\t\t\t\t\t\t\t\t0.418 | \n\t\t\t\t\t\t\t\t0.095 | \n\t\t\t\t\t\t\t
Haptic Discrimination Threshold
First, as a reference of the matching process, subjects were presented a standard stimulus in three ways: only haptic, only visual, and both. When subjects are indicated to observe the object by using only haptic, subjects close the eyes, and then the experimenter leads their hand onto the object. When subjects are indicated to observe the object by only vision, subjects watch the object with putting their hands on the experimental table. When subjects are indicated to observe the object by using haptic and vision, subjects can watch and touch the object without any physical constraints.
\n\t\t\t\tAfter observing a standard stimulus, subjects are required to determine a corresponding stimulus by using only haptic, only vision, and both haptic and vision together. In all trials, subjects are permitted to take as much time as needed. The displayed stimuli for match-up are randomly chosen to control for order effects. When subjects require observing the next stimulus for match-up, the stimulus will be displayed after 15 seconds interval.
\n\t\t\t\tThere are nine combinations of three displaying ways for standard stimulus and three displaying ways for mach-up stimuli. By executing multiple classification analysis to the result derived by the all combinations, we investigate whether human perception is affected by fusing visual and haptic cues.
\n\t\t\t\tIf we conduct the experiment by using all perceivable seven steps for both of visual/haptic discrimination thresholds, huge amount of time and labor is needed. On the other hand, it is difficult to extract significant evidence to show that human perception is affected by fusing visual and haptic cues in the most of the trials, when the one stimulus is too week to affect the other stimulus. Thus, we conduct a preliminary experiment to choose combinations of visual and haptic stimuli that can easily introduce the influence caused by the fusion. As the result, a combination {visual: 2.2 mm / haptic 1.4 mm} is selected.
\n\t\t\tResults are illustrated in Figure 16 and Figure 17. The horizontal axis represents the types of matching procedures, and the vertical axis represents the mean evaluating value of the radii of edges. The line with rhombus nodes is the mean matching response when standard stimuli are presented only by haptic, the line with triangle nodes is only using vision, and the line with box nodes is using haptic and vision together.
\n\t\t\t\tIn the first evaluation, subjects were given a 1.4 mm haptic curvature radius as a haptic stimulus and a 2.2 mm vision curvature radius as a visual stimulus. The result is shown in Figure 16.
\n\t\t\t\tWhen subjects received a standard stimulus as a 1.4 mm haptic curvature radius and determined a corresponding stimulus by only using haptic (the left rhombus node), they sensed it as 1.40±0.0 mm. On the other hand, when subjects received a standard stimulus as a 1.4 mm haptic curvature radius and a 2.2 mm vision one and determined a corresponding stimulus by only using haptic (the left box node), they sensed it as 1.64±0.2 mm by perceiving that the edge was blunter than the previous result. This result was derived by presenting a 2.2 mm vision stimulus as the standard stimulus.
\n\t\t\t\tWhen subjects received a standard stimulus as a 2.2 mm vision curvature radius and determined a corresponding stimulus by only using vision (the right triangle node), they sensed it as 2.20±0.0 mm. On the other hand, when subjects received a standard stimulus as a 1.4 mm haptic curvature radius and a 2.2 mm vision one and determined a corresponding stimulus by only using vision (the right box node), they sensed it as 2.12±0.4 mm by perceiving that the edge was sharper than the previous result. This result was derived by presenting a 1.4 mm haptic stimulus as the standard stimulus.
\n\t\t\t\tWhen subjects received a standard stimulus as a 1.4 mm haptic curvature radius and a 2.2 mm vision one and determined a corresponding stimulus by using both haptic and vision (the middle box node), they sensed it as 1.84±0.1 mm. This experiment shows that the haptic stimulus seems to be affected by visual stimulus when discrepancy exists between vision and haptic stimuli.
\n\t\t\t\tBy applying the Student\'s t-test to our evaluation data, significance differences were found in effectiveness, caused by presenting a standard stimulus in three ways (F(2.18) = 26.694, p<0.05).
\n\t\t\t\tMean grit sizes selected as matches for visual/haptic, and visual/haptic standards; subjects touched an object with a 1.4 mm haptic curvature radius and a 2.2 mm vision one.
In the second evaluation, we switch the value of visual/haptic stimuli to control the order effect. Thus, a subject is given a 2.2 mm haptic curvature radius as a haptic stimulus and a 1.4 mm vision curvature radius as a visual stimulus. The result is shown in Figure 17.
\n\t\t\t\tWhen subjects received a standard stimulus as a 2.2 mm haptic curvature radius and determined a corresponding stimulus by only using haptic (the left rhombus node), they sensed it as 2.20±0.0 mm. On the other hand, when subjects received a standard stimulus as a 2.2 mm haptic curvature radius and a 1.4 mm vision one and determined a corresponding stimulus by only using haptic (the left box node), they sensed it as 2.16±0.2 mm by perceiving that the edge was sharper than the previous result. This result is derived by presenting a 1.4 mm vision stimulus as the standard stimulus.
\n\t\t\t\tWhen subjects received a standard stimulus as a 2.2 mm haptic curvature radius and a 1.4 mm vision one and determined a corresponding stimulus by using both haptic and vision (the middle box node), they sensed it as 2.04±0.2 mm. This experiment shows that the haptic stimulus seems to be affected by visual stimulus when discrepancy exists between vision and haptic stimuli.
\n\t\t\t\tBy applying the Student\'s t-test to our evaluation data, significance differences were found in effectiveness, caused by presenting a standard stimulus in three ways, (F(2.18)=36.394, p<0.05).
\n\t\t\t\tMean grit sizes selected as matches for visual/haptic, and visual/haptic standards; subjects touched an object with a 2.2 mm haptic curvature radius and a 1.4 mm vision one
These results of subjective evaluations for the sharpness of a cube’s edge show that users perceive an edge to be controllable by presenting a duller or sharper CG edge.
\n\t\t\t\tWe calculated the occupancy rate of haptic and vision stimuli for the evaluations by using the method introduced in Lederman’s paper (Lederman & Abbott, 1981). Haptic and visual influences are calculated by the following equations:
\n\t\t\t\tIn these equations, Mean (Touch+Vision standard) is the mean evaluating value of the radius of an edge calculated from all subject evaluations that were presented standard haptic and vision stimuli. Mean (Vision standard) is the mean evaluating value of the radius of an edge calculated from all subject evaluations that were presented a standard vision stimulus. Mean (Touch standard) is the mean evaluating value of the radius of an edge calculated from all evaluations that were presented a standard haptic stimulus.
\n\t\t\t\tIn the first evaluation, the occupancy rate of the vision stimulus is 57.1% and the haptic stimulus is 42.9%. In the second evaluation, the occupancy rate of the vision stimulus is 77.8% and the haptic stimulus is 22.2%. These results show that when a curvature radius becomes larger, the haptic sensation becomes duller. As a result, the occupancy rate of the vision stimulus increases.
\n\t\t\tThis chapter introduced a system that can present visual/haptic sensory fusion using mixed reality. We investigated whether visual cues affect haptic cues. As a procedure to analyze sensory properties, we focused on two features of objects. One is the impression of texture that is intimately involved in the impression of products. The other is the sharpness of edge, which is strongly affected by both visual and haptic senses. From the result of the subjective evaluation on the impression of visual/haptic texture, we can derive an interesting assumption as follows; if we have learned from past experience that a material may sometimes have different haptic impressions (e.g., smooth and rough), we can control the haptic impression of a real object with the material by changing the visual texture overlaid on the object. Preliminary results of subjective evaluations on the sharpness of edge show that users perceive an edge to be duller or sharper than a real one when presented with an overlaid CG edge with a duller/sharper curvature.
\n\t\tMutagenicity is the process of induction of permanent heritable changes in the DNA sequence of living systems [1]. It is caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA repair, replicationand recombination [2]. A number of mutagens have been recognized in our environment recently as many factors which modulate the toxic activities either in vitro or in vivo [3]. Agents contributing to mutagenesis in the environment could be from wide-spectrum applications of biocides in the agriculture, industrial sources, and other contaminants [3].
\nThese mutagenic chemicals have severe drawbacks in humans such as cancer and various inherited diseases; therefore, it is important to detect such mutagenic agents precisely and rapidly and also look for solutions to combat them [2].
\nNatural occurring dietary antimutagens such as healthy protective foods such as fruits and vegetables could strongly counteract the deleterious effect of these mutagens [4]. Additionally, the World Health Organization (WHO) revealed that one-third of all cancer death incidences are preventable depending on the diet type especially health protective phytochemicals that provide an effective solution to these concerns [4]. The current chapter will present the mutagenic events and a brief compilation of the existing scientific findings either from dietary sources or synthetic agents that have the potential activity to combat the disorders caused by the mutagenic agents, putting in mind possible future perspectives and mechanism of antimutagenics [2].
\nSeveral classes of antimutagenic compounds may be distinguished based on their mechanism of action as the following:
\nReactive oxygen species (ROS) are generated by many mutagens; therefore, the removal of reactive molecules is considered an important strategy in the process of antimutagenesis. It is reported that compounds with antioxidant propertiescan remove ROS before these molecules react with DNA, resulting in a mutation [5].
\nIt was reported that the antigenotoxic effects of Lipoic acid (LA) (Figure 1) against mitomycin-C induced chromosomal aberrations, sister chromatid exchanges, and micronucleus formation was observed in human peripheral lymphocytes. Moreover, LA exhibits both anticlastogenic and antimutagenic activity [6].
\nLipolic acid.
A potential protective mechanism against mutagenesis is related to the direct chemical interaction between a mutagen and an antimutagenic compound before it induces DNA damage leading to the inhibition of their damaging activity. Sulfhydryl compounds, such as cysteine, can inactivate 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) (Figure 2) [7].
\n(a) Mutagen (MX) and (b) antimutagen (cysteine).
The mechanism of action for this type of antimutagenics is to prevent mutagenic compounds from reaching target sites such as nucleophilic bichalcophenes (Figure 3). They might be able to bind to DNA and, therefore, protect genetic materials from electrophilic mutagenic agents [8].
\nBichalcophene derivatives.
Various antimutagenic agents work through multiple mechanisms affording protection against several mutagens. Noteworthy, the ability of compounds to affect mutagens simultaneously in varied ways significantly enhances antimutagenic effectiveness. Hence, searching for such multifunctionally acting antimutagens is of great importance [9].
\nThis way of preventing induced cellular mutagenesis depends on mutagens that are inactivated before they can attack the DNA in vitro [3].
\nDamaged DNAusually requires fixation steps (e.g., DNAreplication and/or repair) before it can be expressed as stable and heritable mutant genes. Hence this mechanism relates to interference with some aspects of cellular DNA fixation processes working on reducing genetic damage in DNA [3].
\nAntimutagenic agents are able to combat the disorders caused by mutagens [10]. This group of agents includes both natural and synthetic compounds categories [1].
\nThe antimutagenic effect of natural sources was investigated due to certain compounds in them or due to whole extract.
\nIt is the first naturally occurring organic antimutagen [11]; it has been involved in screening and chemical studies of such biologically active substances [12]. Antimutagenic action is attributed to either by a selective killing effect of cells which have premutation lesion of DNA via inhibition of the errorprone SOS repair system, or by enhancement of the error-free DNA repair system (Figure 4) [13].
\nCinnamaldehyde.
Punicalagin is an ellagitannin found in the fruit peel of
(a) Punicalagin (b) ellagic acid.
Luteolin derivatives (luteolin 7-O-rutinoside, luteolin 7-O-glucoside, and luteolin 7-O-glucuronide) (Figure 6) are isolated from
Luteolin derivatives.
\n
Acetogenins.
Pinocembrin and cardamonin (Figure 8) are found in Sozuku (Chinese drug from dried seed of
Pinocembrin and cardamonin.
It isa type of iridoid glycoside. HS (Figure 9) is considered as the main active component extracted from
Harpagoside (HS)
Natural oleoresin is rich in lycopene (Figure 10), which was obtained from two types of tomato (Zedona and Gironda). The antimutagenic activity of oleoresin was tested against aflatoxin B1 (AFB1), and both varieties had awfully high antimutagenic potential against AFB1 (60–66%) [20].
\nLycopene.
The powdered extract of
Glycyrrhiza aspera root extract.
It was found that
These two plants are both rich in compounds of the tanninand flavonoid groups and frequently employed in folk medicine. Antimutagenicity was determined against known mutagenic substances such as 4-oxide-1-nitroquinoline, NaN3, aflatoxin B1, 2-aminofluorene and 2-aminoanthracene, and 2-nitrofluorene using the
Aqueous and acidified methanol extracts of CLFR were evaluated for their total phenolic contents and antioxidant and antimutagenic activities. Antimutagenic potential of the extracts was done by Ames test. The results supported that the extracts from CLFR were mutagenically safe due to its high phenolic content which can act as antioxidant and anitmutagenic [24].
\nThe genotoxic effect of MT was investigated by using both micronucleus test and Ames test in
It is an extract of
Although
The essential oils of
The methanolic extract of HI reduced the mutagenicity of benzo[a]pyrene, norfloxacin, and 2-aminoanthracene. The antigenotoxic properties could be due to the antioxidant properties of component into extract such as catenanes, sterols, polyacetylenes, triterpenes, sesquiterpenes, flavonoids, and flavonoid glycosides [29].
\nLiteratures revealed that this extract displayed potent antioxidant and antimutagenic activities [30]. Also chloroform extract showed antimutagenic effect against both direct- and indirect-acting mutagens, as the extract may act as a blocking agent that is capable of influencing the activities of enzymes engaged in the metabolism of mutagens and carcinogens. Moreover, the tested extract displayed the ability to react directly with the mutagens electrophilic metabolite sand was capable of protecting against oxidative DNA damage [30].
\nIt was reported that wheat bran provides antimutagenic effects that related to the presence of the antioxidant phytic acid. It was demonstrated that phytic acid may intercept carcinogenic azoxymethane, inhibiting it even before it can damage DNA. Moreover, antioxidants included in wheat bran are able tomodulate DNA repair enzymes [31].
\nActivity was displayed by beets, chives, horseradish, onions, rhubarb, and spinach. All cruciferous vegetables showed strong to moderate antimutagenic activities, except Chinese cabbage, which displayed weak activity. Moderate antimutagenicity was found in green beans and tomatoes, whereas weak activities in egg plant, garden cress, many types of lettuces, leeks, mangold, cucumber, pumpkin, radish, and summer squash. However, some vegetables such as
Antimutagenic activity of many vegetable juiceswere earlier studied againstmutagenicity induced by2-amino-3-methyl[4,5-f]-quinoline (IQ), 2-amino-3,4dimethylimidazo[4,5-f] quinoline (MeIQ) or 2-amino3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) in S.typhimurium TA98 and TA100 [33].
\nCurrent research all over the world has focused on health protectiveproperties of fruits including antimutagenic potential of different fruittypes and their cultivars. Concerning apple fruit, its antioxidant and radioprotective properties were found to be better correlated with its antimutagenic effect [34]. Recently, copaiba, an exotic Brazilian fruit, possesses the antimutagenic potential of copaiba powder (dose of 100 mg/kg) showing great reduction of micronuclei [35].
\n\n
It was demonstrated that ethyl acetate extract of macro fungus showed the in vitro antimutagenic activity of
Synthetic antimutagens is another important trend in the area of antimutagenicity research.
\nBile acids have either a co- or an antimutagenic activity toward various direct- and indirect-acting mutagens [38]. It was reported that steroidal hormones could inhibit the genotoxicity of both direct- and indirect-acting mutagens [39]. For example, both ethinyl oestradiol and mestranol (Figure 12), which are synthetic derivatives of 3-estradiol largely used in contraceptive pills, are strong mutagenic inhibitors acting at nanomolar concentrations [39].
\nSteroidal hormonal molecules
It could act as a nucleophile to scavenge the electrophilic mutagens. It was implied that gallic acid (Figure 13) can bind or insert into the outer membrane transporters leading to the blockage of a mutagen that was transferred intothe cytosol [40]. One of the mutagenic substances that gallic acid affects is NaN3. It is widely used in agriculture, industry, and medicine, but it is a highly toxicsubstance. If sodium azide is found in the intracellular milieu, azide ions bind Fe3þ in hemoglobin and inhibit the respiratory chain of metabolism [41].
\nGallic acid.
The anticlastogenic effect of tannic acid (Figure 14) was studied
Tannic acid.
Theantigenotoxic potential of two newly synthesized β-aminoketones such as2-{(4-bromophenyl)[(4-methylphenyl) amino] methyl} cyclohexanone and 2-{(4-chlorophenyl)[(4-methylphenyl) amino] methyl} cyclohexanone compounds was tested against the mutagenN-methyl-N-nitro-N-nitrosoguanidine (MNNG), acting by DNAmethylation (Figure 15) [9]. The antimutagenic potential of these compounds may be related to the inhibition of the production of O6-methylguanine, a product of MNNG that is related to its mutagenic effect. Both compounds also abolished mutagenesis induced by 9-AA that binds to DNA noncovalently by intercalation [43].
\nβ-Aminoketones and mutagens.
This category of antimutagenics acts against mutagens via either intracellularor extracellular mechanisms [44]. The extracellular mechanism showed interference with the cytochrome P450-mediated metabolismof these mutagens and the interaction with active mutagenicmetabolites [8]. Moreover, the antimutagenic potency of these compounds may be relatedto DNA protection from mutagens presenting electrophilicproperties [8].
\nHydroxyphenyliminoligands and their metal complexes [Cu(II), Co(II), Ni(II) and Mn(II) complexes] of usnic acid (Figure 16) which is isolated from
Usnic acid.
New polymeric microspheres containing azomethine were designed and synthesized to evaluate their antimutagenic activity against NaN3, among of them; a new polymeric microspheres containing azomethine (Figure 17) which contains R = CH3 had potent antimutagenic effect against NaN3 [46].
\nNew polymeric microspheres containing azomethine.
Chitosan derivatives containing quaternary ammonium groups and di (tertbutyl) phenol (TBPh) (Figure 18) in the polymer side chain improved the antimutagenic efficiency of the polymer from 48 to 93% [47].
\nChitosan derivatives containing quaternary ammonium groups.
Hydrazone derivatives were synthesized to study their antioxidant and antimutagenic activity against 4-NPD and NaN3 in
Hydrazone derivatives
The potential antimutagenic of xanthonesis attributed to different mechanisms, such as the rapid elimination of mutagens from bacteria; the interaction between antimutagens and the reactive intermediates of mutagens; and the influence on microsomal enzymes against direct mutagen 4-nitroquinoline-N-oxide (NQNO) (Figure 20) [49].
\nXanthone.
Novel polymeric-Schiff bases including indol (L1, L2, L3) (Figure 21) exhibited the antigenotoxic properties against sodium azide in human lymphocyte cells by micronuclei (MN) and sister chromatid exchange tests [50].
\nNovel polymeric-Schiff bases.
A series of indolizine derivatives have been synthesized to determine their antimutagenic activity, the indolizine derivative (Figure 22) had the highest activity [51].
\nIndolizine.
Scientists demonstrated that this series of compounds are protected against genotoxicity and oxidative stress induced by an indirect-acting mutagen CP [52]. This is attributed to effect of CP on DNA through its alkylating properties and free radicals production [53].
\nThe novel bichalcophenes significantly decreased the mutagenicity induced by two mutagens, namely, NaN3 and BP [54]. It was found that the antimutagenic potential of the compounds could be attributed to their antioxidant activity [55].
\nNew zerumbone-bicarbonyl analogues were synthesized to determine their antimutagenic activity against
1,4-Dihydropyridines (1,4-DHP) (
1,4-Dihydropyridines (1,4-DHP) derivatives.
Two newly synthesized oxadiazoles: 1,3-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M1) and 1,4-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M2) (Figure 25) were synthesized and studied in
Oxadiazole derivatives.
Dihydrothienoquinoline derivatives were designed and synthesized to evaluate their antimutagenicity using Ames test. Several compounds showed good antimutagenicity. The results for compounds (Figure 26) were found to be statistically significant (P = 0) [58].
\nDihydrothienoquinoline derivatives.
A series of novel azacrown ether Schiff bases have been synthesized, and they were investigated for their antimutagenic activities using the spot test and Ames test using strains TA1535, TA100, and TA97a of
Azacrown ether Schiff bases.
The authors declare no conflict of interest.
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",metaTitle:"Retraction and Correction Policy",metaDescription:"Retraction and Correction Policy",metaKeywords:null,canonicalURL:"/page/retraction-and-correction-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
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\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
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This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for the development of novel separation techniques.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Siti Zullaikah, Orchidea Rachmaniah, Adi Tjipto Utomo, Helda\nNiawanti and Yi Hsu Ju",authors:[{id:"190944",title:"Ph.D.",name:"Siti",middleName:null,surname:"Zullaikah",slug:"siti-zullaikah",fullName:"Siti Zullaikah"},{id:"191020",title:"Dr.",name:"Adi",middleName:null,surname:"Utomo",slug:"adi-utomo",fullName:"Adi Utomo"},{id:"191021",title:"Prof.",name:"Yi Hsu",middleName:null,surname:"Ju",slug:"yi-hsu-ju",fullName:"Yi Hsu Ju"},{id:"207289",title:"MSc.",name:"Orchidea",middleName:null,surname:"Rachmaniah",slug:"orchidea-rachmaniah",fullName:"Orchidea Rachmaniah"},{id:"220747",title:"MSc.",name:"Helda",middleName:null,surname:"Niawanti",slug:"helda-niawanti",fullName:"Helda Niawanti"}]},{id:"56734",doi:"10.5772/intechopen.70421",title:"Ionic Liquids as Green Corrosion Inhibitors for Industrial Metals and Alloys",slug:"ionic-liquids-as-green-corrosion-inhibitors-for-industrial-metals-and-alloys",totalDownloads:2166,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Present chapter describes recent advances in the field of development of ionic liquids as green and sustainable corrosion inhibitors for metals and alloys. The present chapter has been divided into several sections and subsections. Recently, development of the green and sustainable technologies for the corrosion prevention is highly desirable due to increasing ecological awareness and strict environmental regulations. In the last two decades, corrosion inhibition using ionic liquids has attracted considerable attention due to its interesting properties such as low volatility, non-inflammability, non-toxic nature, high thermal and chemical stability and high adorability. Several types of ionic liquids have been developed as “green corrosion inhibitors” for different metals and alloys such as mild steel, aluminum, copper, zinc, and magnesium in several electrolytic media. The ionic liquids are promising, noble, green and sustainable candidates to replace the traditional volatile corrosion inhibitors.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Chandrabhan Verma, Eno E. Ebenso and Mumtaz Ahmad Quraishi",authors:[{id:"35005",title:"Prof.",name:"Eno",middleName:null,surname:"Ebenso",slug:"eno-ebenso",fullName:"Eno Ebenso"},{id:"207838",title:"Prof.",name:"Mumtaz",middleName:null,surname:"Quraishi",slug:"mumtaz-quraishi",fullName:"Mumtaz Quraishi"},{id:"215227",title:"Dr.",name:"Chandrabhan",middleName:null,surname:"Verma",slug:"chandrabhan-verma",fullName:"Chandrabhan Verma"}]},{id:"49733",doi:"10.5772/62079",title:"Breakthroughs in Indole and Indolizine Chemistry – New Synthetic Pathways, New Applications",slug:"breakthroughs-in-indole-and-indolizine-chemistry-new-synthetic-pathways-new-applications",totalDownloads:2699,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"Indole and indolizines (heterocyclic aromatic compounds structurally and chemically isomeric with indoles) are an important class of N-fused heterocyclic compounds due to their interesting biological and optical properties. Different strategies for generating diverse collections of small molecules with indole and indolizine moieties have been developed. They can be synthesized by means of classical and nonclassical pathways. The present study discusses the versatile nature of indole/indolizine derivatives, new green methods for their synthesis, their possible mechanism of action and also provides information about current/future prospects of the topics and different indole/indolizine derivatives in pharmaceutical/clinical trials. With the remarkable number of approved indole-containing drugs as well as the importance of the indolizine moiety, it can be easily concluded that indole and indolizine derivatives offer perspectives on how pyrrole scaffolds might be exploited in the future as bioactive molecules against a broad range of diseases.",book:{id:"5108",slug:"scope-of-selective-heterocycles-from-organic-and-pharmaceutical-perspective",title:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective",fullTitle:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective"},signatures:"Ioana Otilia Ghinea and Rodica Mihaela Dinica",authors:[{id:"177239",title:"Prof.",name:"Rodica Mihaela",middleName:null,surname:"Dinica",slug:"rodica-mihaela-dinica",fullName:"Rodica Mihaela Dinica"},{id:"177240",title:"Dr.",name:"Ioana Otilia",middleName:null,surname:"Ghinea",slug:"ioana-otilia-ghinea",fullName:"Ioana Otilia Ghinea"}]}],mostDownloadedChaptersLast30Days:[{id:"57200",title:"Introductory Chapter: Principles of Green Chemistry",slug:"introductory-chapter-principles-of-green-chemistry",totalDownloads:2817,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Hosam El-Din Mostafa Saleh and M. Koller",authors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"},{id:"218817",title:"Dr.",name:"Martin",middleName:null,surname:"Koller",slug:"martin-koller",fullName:"Martin Koller"}]},{id:"56734",title:"Ionic Liquids as Green Corrosion Inhibitors for Industrial Metals and Alloys",slug:"ionic-liquids-as-green-corrosion-inhibitors-for-industrial-metals-and-alloys",totalDownloads:2165,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Present chapter describes recent advances in the field of development of ionic liquids as green and sustainable corrosion inhibitors for metals and alloys. The present chapter has been divided into several sections and subsections. Recently, development of the green and sustainable technologies for the corrosion prevention is highly desirable due to increasing ecological awareness and strict environmental regulations. In the last two decades, corrosion inhibition using ionic liquids has attracted considerable attention due to its interesting properties such as low volatility, non-inflammability, non-toxic nature, high thermal and chemical stability and high adorability. Several types of ionic liquids have been developed as “green corrosion inhibitors” for different metals and alloys such as mild steel, aluminum, copper, zinc, and magnesium in several electrolytic media. The ionic liquids are promising, noble, green and sustainable candidates to replace the traditional volatile corrosion inhibitors.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Chandrabhan Verma, Eno E. Ebenso and Mumtaz Ahmad Quraishi",authors:[{id:"35005",title:"Prof.",name:"Eno",middleName:null,surname:"Ebenso",slug:"eno-ebenso",fullName:"Eno Ebenso"},{id:"207838",title:"Prof.",name:"Mumtaz",middleName:null,surname:"Quraishi",slug:"mumtaz-quraishi",fullName:"Mumtaz Quraishi"},{id:"215227",title:"Dr.",name:"Chandrabhan",middleName:null,surname:"Verma",slug:"chandrabhan-verma",fullName:"Chandrabhan Verma"}]},{id:"49951",title:"Significance of Thiazole-based Heterocycles for Bioactive Systems",slug:"significance-of-thiazole-based-heterocycles-for-bioactive-systems",totalDownloads:3634,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Monocyclic and Bicyclic aromatic heterocycles such as imidazoles, thiazoles, thiadiazoles, oxazoles, oxadiazoles quinazolines, indoles, benzimidazoles, purines pyrido[4,3-d]pyrimidines, thiazolo[5,4-d]pyrimidines, thiazolo[4,5-d]pyrimidines, oxazolo[5,4-d]pyrimidines and thieno[2,3-d]pyrimidines are renowned pharmacophores in drug discovery. These special structures are well explained and exemplified in chemical compound libraries. In this chapter, several types of thiazole based heterocyclic scaffolds such as monocyclic or bicyclic systems synthesis and their biological activities studies are presented, which are not frequently present in books and reviews. We mention the first importance of synthetic route of various thiazole based compounds and their applications in medicinal chemistry in this chapter.",book:{id:"5108",slug:"scope-of-selective-heterocycles-from-organic-and-pharmaceutical-perspective",title:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective",fullTitle:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective"},signatures:"Someshwar Pola",authors:[{id:"177037",title:"Dr.",name:"Someshwar",middleName:null,surname:"Pola",slug:"someshwar-pola",fullName:"Someshwar Pola"}]},{id:"51672",title:"Recent Advances in Sustainable Organocatalysis",slug:"recent-advances-in-sustainable-organocatalysis",totalDownloads:2698,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"The recent advances on green and sustainable organocatalysis are revised in this chapter. An important focus on one of the 12 principles of green chemistry, organocatalysis pursues to reduce energy consumption as well as to optimize the use of different resources, targeting to become a sustainable strategy in organic chemical transformations. In last decades, several experimental methodologies have been performed to make organocatalysis an even greener and sustainable alternative to stoichiometric approaches as well as non-catalytic conditions by the use of benign and friendlier reaction media. In this line, several approaches using water as preferential solvent, alternative solvents such as ionic liquids including chiral ones, deep eutectic solvents, polyethylene glycol (PEG), supercritical fluids and organic carbonates or solvent-free methodologies have been reported. In this chapter, we mainly focus on the recent remarkable advancements in organocatalysis using green and sustainable protocols.",book:{id:"5206",slug:"recent-advances-in-organocatalysis",title:"Recent Advances in Organocatalysis",fullTitle:"Recent Advances in Organocatalysis"},signatures:"Luis C. Branco, Ana M. Faisca Phillips, Maria M. Marques, Sandra\nGago and Paula S. Branco",authors:[{id:"18681",title:"Dr.",name:"Luis C.",middleName:null,surname:"Branco",slug:"luis-c.-branco",fullName:"Luis C. Branco"}]},{id:"50746",title:"Recent Advances in Guanidine-Based Organocatalysts in Stereoselective Organic Transformation Reactions",slug:"recent-advances-in-guanidine-based-organocatalysts-in-stereoselective-organic-transformation-reactio",totalDownloads:2296,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Tremendous efforts have been put toward the design and synthesis of newer enantioselective organocatalysts for the enanatioselective synthesis. Recently, guanidine-containing chiral organocatalysts have attracted considerable attention due to their ease of synthesis and high enantioselective catalytic activities. This chapter highlights the successive development of chiral guanidine organocatalysts in asymmetric organic transformation reactions in the past few decades.",book:{id:"5206",slug:"recent-advances-in-organocatalysis",title:"Recent Advances in Organocatalysis",fullTitle:"Recent Advances in Organocatalysis"},signatures:"Shrawan Kumar Mangawa and Satish Kumar Awasthi",authors:[{id:"173269",title:"Prof.",name:"Satish",middleName:null,surname:"Awasthi",slug:"satish-awasthi",fullName:"Satish Awasthi"},{id:"185375",title:"Dr.",name:"Shrawan",middleName:"Kumar",surname:"Mangawa",slug:"shrawan-mangawa",fullName:"Shrawan Mangawa"}]}],onlineFirstChaptersFilter:{topicId:"497",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. 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After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. 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She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"91",type:"subseries",title:"Sustainable Economy and Fair Society",keywords:"Sustainable, Society, Economy, Digitalization, KPIs, Decision Making, Business, Digital Footprint",scope:"\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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