Hydrological database results: Area use allocation (hectares).
\r\n\t
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In many industries, including but not limited to agricultural production, water use and wastewater generation have a major share in the total environmental impact of the production processes.
Integrating water and wastewater processes into industrial processes requires a multi-dimensional analysis that takes into account the various potential water sources, as well as the different options of wastewater treatment available. We developed a model for planning water supply from diverse sources, including groundwater, the water from national supply sources, wastewater reuse and seawater desalination. The model integrates hydrological, technological and economic considerations, and estimates the economic and environmental impacts of alternative water management policies.
The model was implemented on the case study of agricultural production processes, based on the unique geographical characteristics of Emek Heffer and northern Sharon regions in Israel. The hydrological model was developed on the basis of the specific hydrological database for these regions, and enabled to plan the local water resources use and forecast the chlorides concentration in the aquifer. Based on the results of the model and economic data, the costs of desalination processes and of the water supply to the region under various scenarios were estimated. The results include recommendations for the water treatment level and for desalination of different water sources, and forecasts of the implementation costs. We conclude that the economic cost of improving the quality of the supplied water and of the aquifer water should be considered in the planning of agricultural production to reduce its environmental impacts at minimal economic cost.
Designing production processes with reduced environmental impacts is becoming more important. In many industries, including but not limited to agricultural production, water use and wastewater generation have a major share in the total environmental impact of the production processes. At the same time, increasing water shortage has caused an increase in issues related to water pollution as a result of wastewater use, as well as the option of wastewater reuse, mainly for agriculture.
Water use and wastewater production are part of nearly every type of production process, including urban, industrial, and, of course, agricultural. Choosing a different mix of water supply sources, or defining a different quality threshold for wastewater treatment, changes the groundwater quality levels over time; changes the financial costs to both the urban consumers and the farmers (also leading indirectly to changes in the consumer budget); changes the level of health risks faced by the consumers from drinking water and consuming food irrigated with wastewater; and changes the long-term ecological balance.
To address all of these concerns the choice of wastewater reuse and desalination processes should be done from a multidisciplinary view, taking into consideration not only the technological aspects of process design, but also the hydrological impacts, the economic implications for urban consumers and farmers, and the environmental – health and ecosystem – impacts of these processes.
We developed a model for planning water supply from diverse water supply sources, including groundwater, the water from national supply sources, wastewater reuse and seawater desalination, as well as the different options of wastewater treatment available. The model integrates hydrological, technological and economic considerations, and estimates the economic and environmental impacts of alternative water management policies. Through the model, we examine a case study of water supply to a chosen region that consists of both urban and agricultural areas. National and regional policy decisions regarding permits for well drilling, and thresholds for the level of water salinity allowed in drinking water and in water for irrigation can vary between regions, and in the same region over time. We considered the range of policy variations by using a range of potential policy scenarios in the model, and estimating the economic and environmental impacts across these policy scenarios.
The model was constructed as a decision making tool that is meant to enable managers to plan the water supply process to their region, based on combining water from different potential sources, supplied to a combination of different end-users in urban and rural areas of that region. The assumed goals of the decision makers include minimal costs as well as minimal environmental impacts (specifically, minimal groundwater salinity levels). The potential water sources in the model include groundwater, national carrier water, treated wastewater for irrigation, and desalinated sea water.
The model is composed of four sub-components that describe the different types of processes that are part of the decision making complex: policy planning processes, physical hydrological water flow processes, technological water supply and treatment processes, and the economic implications of these processes. The planning sub-component describes the geographical area allocations between different water users. The hydrological sub-component describes the physical structure of the water source supply and is used to predict the aquifer water levels and the salinity concentration over time. The technological sub-component describes the available relevant water treatment and desalination processes and the ensuing costs. The economic sub-component is used to calculate the optimal treatment quantities and levels and the total cost of these decisions.
A.
B.
The hydrological model is based on ten assumptions:
The hydraulic characteristics of each layer are uniform and do not change over time, although they can vary from one cell to another.
Surface water with varying chloride levels seep vertically downward through the unsaturated zone to the saturated zone.
The surface water sources reaching the unsaturated zone may include water from the following sources: rain water, fresh water, wastewater used for irrigation, and water leakage from various sources.
Only part of the water entering the unsaturated zone actually reaches the groundwater (for example, some water uptake by plants may occur in the process); but the chloride mass that is mixed with the water reaches the saturated zone in its entirety.
The chloride moves downward with the water it is dissolved in, at the average rate of water movement, with no dispersion on the way.
There are no additional sources of water or dissolved chlorides in the unsaturated zone.
The flow of the chloride mass from the unsaturated zone to the the saturated zone of each cell is characterized by two consecutive time periods. The first period, Period A, begins with the entry of the water and dissolved chlorides into the unsaturated zone; the second period, Period B, begins when that water first reaches the saturated zone.
In addition to the flow that enters from the unsaturated zone, water and dissolved chlorides may also enter a given hydrological cell from its neighboring cells and from drilling.
The chloride mass in the cell\'s unsaturated zone is concentrated in an area termed “the mixing area”. Which lies from the groundwater surface to the depth of the drilling for pumping water out.
The systems\' land borders – the eastern, northern and southern borders – are impervious to entry of water and salt. The western border is an open border (reaching the sea).
The water supply is designated for two sectors: town and agriculture, which receive two types of water – fresh water and wastewater. The hydrological model is based on hydrological and planning input data, and enables to produce outputs for each one of the cells that include water balances and chloride masses as well as forecasts of water levels and chloride concentrations in the saturated zone, over a pre-defined period of time.
The hydrological model was used to quantify the potential water quantity available for pumping water in each hydrological cell, under the assumption that in each cell the water supply is equal to the water demand. The water sources for each hydrological cell were computed under the assumption of giving first priority to water supply from local sources, i.e., pumping from drillings in that cell\'s area, which is done within the limitation of the available water quantity, and under the limitations of the total annual pumping allowed from that aquifer. The volume of the additional water needed as supplement to fill the total water demand is supplied by National Carrier water, and the water consumers in the hydrological cells along the beach can only get their water from that national source. Agricultural use is given priority in water pumping, and irrigation with wastewater will continue at its present volume.
The predefined salinity threshold was based on policy considerations relating to the water supplied to the city, or to the city and agricultural uses, or for groundwater under a steady state condition. Our aim was to examine the implications of policy choices regarding different water quality thresholds on the level of groundwater salinity over time and on the costs of water supply to the region.
To do that, we examined a variety of scenarios that defined the threshold levels between the range of 50 to 250 mg Chlorides per liter (mg/Cl.). The forecasted level of groundwater salinity over one hundred years was computed for each scenario, based on the hydrological model\'s mathematical equations.
We compared the different scenarios for a steady-state solution, defined as a situation where the groundwater level and the chloride concentration in each cell do not change over time. The steady-state solution for the groundwater level is calculated by solving the set of equations for the annual water balance volume in the cells, when the total volume of water entering the cell from the unsaturated zone and from the neighboring cells is equal to the total volume of water that is pumped out of the cell. The steady-state of chloride concentration in the groundwater of each cell is calculated by solving the set of equations for the annual balance of chloride mass in the cells; that is, multiplying the components of the steady-state water balance with the target concentrations, when the total chloride mass entering the cell is equal to the total mass of chlorides that is pumped out of that cell.
C.
The desalination costs are influenced by different parameters such as the size of the plant, the quality of the feeding water and placement of the wastewater plant. The costs are also influenced by a number of planning variables, including rate of return on investment, various expenditure processes, the availability of plant operations, energy costs, membranes, chemicals, manpower, maintenance and overhead costs. The input data include: water quantity, the quality of the raw data that we fed into the system, the quality of the final product, rates of absorption, depth of drilling, pipe lengths, altitude of the desalination plant and volume of water storage.
D.
The model was implemented on a specific case study region, composed of eight hydrological cells located along the coast in the central/north-central part of Israel. The area includes the city of Netanya, whose urban wastewater flow is the main source of the total wastewater supply to the region. The case study region was further divided into two sub-regions - Emek Heffer and Northern Sharon - each composed of four hydrological cells. The Emek Heffer hydrological cells lie on the northern border of the Northern Sharon hydrological cells, and parallel to them.
The Israel National Hydrological Service divides the shore aquifer area into 16 areas, and each area includes four hydrological cells, lying from west to east. The Western Shore cells are the cells closest to the beach, followed by Western Aquifer cells and Eastern Aquifer cells, where most of the pumping in concentrated, and finally by the Eastern cells. The cells are divided by straight lines that divide the entire coastal area into square cells, with no consideration for the division of the areas according to geographical characteristics or urban administrative borders. Establishing a data base by hydrological cells was very complex, because the information needed for the allocation of the area among users and water uses does not exist for each individual hydrological cell.
We established the database by hydrological cells using a set of maps that included the administrative urban areas, horticultural areas by crop and built area. The combined maps resulted in the calculated area allocation presented in Table 1. The Emek Heffer area is mostly agricultural, while in the Northern Sharon area, which includes the city of Netanaya, close to half the area is defined as an urban area.
Area | Emek Heffer | |
Total agricultural | 8.24 | 8.28 |
Build area | 1.02 | 1.14 |
Citrus crops | 1.21 | 2.89 |
Other horticultural crops | 0.69 | 1.05 |
Field crops (estimation) | 5.30 | 3.19 |
Total urban area | 0.11 | 7.87 |
Total area | 8.35 | 16.16 |
Hydrological database results: Area use allocation (hectares).
For each hydrological cell we estimated the demand for water by type of users, based on established norms of water use by crop and water use by number of residents. The amount of wastewater used for irrigation was given. As Table 2 shows, the total water use in Emek Heffer was 24.6 million cubic meters (mcm) per year, of which 90% was used for irrigation, while in Northern Sharon the total use was 59.4 mcm/year, of which 58 percent was used for irrigation (in both areas the irrigation water use includes the wastewater data).
Type of water use | Emek Heffer | Total | |
Urban water use | 2.6 | 24.7 | 27.3 |
Freshwater for agriculture | 9.6 | 31.3 | 40.9 |
Total demand for freshwater | 12.2 | 56.0 | 68.2 |
Wastewater | 12.4 | 3.4 | 15.8 |
Total irrigation water | 22.0 | 34.7 | 56.7 |
Total demand for water | 24.6 | 59.4 | 84.0 |
Hydrological database results: Water use allocation (mcm).
The results of the planning component, including area allocation and water use for each hydrological cell, as described above, was used as input data for the hydrological component, which was applied to predict the groundwater level and salinity over time, and for the technological component, which was applied to examine the relevant desalination technologies and the ensuing costs. The results of the hydrological and technological components were used in turn as inputs for the economic component, which was applied to evaluate and compare the the scope of desalination and the costs under different scenarios.
The hydrological component was based on the results of the planning component, as described above. The levels of salinity are predicted over time for a variety of scenarios, who differ from each other in the predefined salinity thresholds permitted for urban and agricultural use. The baseline scenario – scenario 1 – describes a policy of defining a establishing a threshold of 250 mg/Cl., only for urban use. Scenarios 2, 3 and 4 include established thresholds for agricultural water use, at the levels of 250 (scenario 2), 150 (scenario 3), and 50 mg/Cl (scenario 4). The fifth scenario – scenario 5 – describes an agricultural area on the one extreme, which based on freshwater irrigation alone, and the final scenario – scenario 6 – is description of the opposite extreme scenario, which allows irrigation with highly saline wastewater. The scenarios are summarized in Table 3.
For each scenario, we predicted the groundwater salinity levels over time and after one hundred years. The salinity level was found to increase over time in every hydrological cell except for the two Western Shore cells, where pumping is not allowed. The results for each scenario are presented in Table 4. For the baseline scenario (scenario 1), the salinity in year 100 in the Emek Heffer region reaches 846, 497, and 1192 mg/Cl for the Western Aquifer cell, Eastern Aquifer cell and Eastern cells, respectively. The salinity levels in year 100 in the Northern Sharon area under this scenario reach 132, 100, and 739 mg/Cl for the Western Aquifer cell, Eastern Aquifer cell and Eastern cells, respectively.
Scenario | Salinity threshold for urban water use (mg/Cl.) | Salinity threshold for agricultural water use (mg/Cl.) | Irrigation with wastewater included? |
1 (baseline) | 250 | - | Yes |
2 | 250 | 250 | Yes |
3 | 150 | 150 | Yes |
4 | 50 | 50 | Yes |
5 | 250 | - | No |
6 | 250 | - | Yes, with high salinity |
Scenarios for the model.
Cell | Scenario 1 Urban threshold 250 mg/Cl. | Scenario 2 Add agricultural threshold 250 mg/Cl. | Scenario 3 Add agricultural threshold 150 mg/Cl. | Scenario 4 Add agricultural threshold 50 mg/Cl. | Scenario 5 No irrigation with wastewater | Scenario 6 Irrigation with highly saline wastewater |
Emek Heffer | ||||||
310 | 189 | 210 | 137 | 232 | 370 | |
Western Aquifer | 846 | 459 | 364 | 182 | 741 | 1016 |
Eastern Aquifer | 497 | 358 | 243 | 110 | 418 | 644 |
Eastern | 1192 | 841 | 690 | 364 | 1639 | 1485 |
Entire Emek Heffer | 716 | 453 | 357 | 182 | 716 | 907 |
180 | 115 | 159 | 122 | 161 | 192 | |
Western Aquifer | 132 | 150 | 116 | 75 | 133 | 143 |
Eastern Aquifer | 100 | 102 | 94 | 66 | 91 | 112 |
Eastern | 739 | 654 | 438 | 222 | 693 | 760 |
Entire | 158 | 159 | 130 | 84 | 157 | 174 |
Predicted chloride concentration in groundwater in year 100 by scenario (mg/Cl.).
Scenarios 1 – 4 describe a gradual increase in the strictness of the water quality regulations. Scenario one, as mentioned above, includes predefined salinity thresholds for urban use alone, while scenarios 2 – 4 include salinity thresholds for agricultural water use as well, with the level of salinity permitted becoming gradually lower from scenario 2 to scenario 4. Comparing the different scenarios for a given cell, by examining each row individually across the first four columns of Table 4, shows that as the policy becomes more strict, the resulting salinity level over time is lower. For example, looking at the results for Emek Heffer\'s Eastern Aquifer cell, the chloride concentration in year 100 is 497 mg/Cl under the baseline scenario, which defines only urban water use thresholds, and becomes gradually lower through scenario 2 with an added restriction of 250 mg/Cl for agricultural water use as well, resulting in a salinity level of 358 in year 100; scenario 3, with an increased restriction of agricultural water use salinity level to 150 mg/Cl resulting in a groundwater chlorine concentration level of 243 mg/Cl in year 100; and finally scenario 4, which has the greatest salinity level restriction, permitting only 50 mg/Cl, and resulting in the lowest salinity level of 110 mg/Cl in year 100. Comparing scenario 5, which does not include any irrigation with wastewater, with scenario 6, which includes irrigation with highly saline wastewater, shows that irrigation with freshwater alone decreases the level of groundwater salinity in year 100 by 191 mg/Cl for the entire area of Emek Heffer.
We calculated the predicted chloride concentration under a steady-state situation, where the groundwater level and the chloride concentration in each cell do not change over time (Table 5). Under the baseline scenario, with a salinity threshold for urban water use alone of 250 mg/Cl, the resulting salinity level in the aquifer water under steady-state conditions is 1,358 mg/Cl in Emek Heffer and 318 mg/Cl in Northern Sharon. Under scenario 2, which includes a threshold of 250 mg/Cl for both urban and agricultural water use, the aquifer steady-state salinity level is 553 mg/Cl in Emek Heffer and 265 mg/Cl in Northern Sharon.
Scenario 1: urban threshold of 250 mg/Cl | Scenario 2: both urban & agricultural thresholds of 250 mg/Cl | |||
Cell | Year 100 | Steady-State | Year 100 | Steady-State |
Emek Heffer | ||||
310 | 704 | 189 | 329 | |
Western Aquifer | 846 | 1358 | 459 | 514 |
Eastern Aquifer | 497 | 548 | 358 | 380 |
Eastern | 1192 | 2884 | 841 | 977 |
Entire Emek Heffer | 716 | 1358 | 453 | 553 |
180 | 176 | 115 | 174 | |
Western Aquifer | 132 | 200 | 150 | 197 |
Eastern Aquifer | 100 | 244 | 102 | 204 |
Eastern | 739 | 1184 | 654 | 670 |
Entire | 158 | 318 | 159 | 265 |
Chloride concentration in year 100 and under steady-state conditions (mg/Cl).
The calculated chloride concentration in irrigation water needed to maintain an aquifer salinity threshold of 250 is shown in Table 6. For the entire Emek Heffer area, for example, the permitted chloride concentration in irrigation water would be 92 mg/Cl.
Scenario / Cell | Scenario 1 Urban threshold 250 mg/Cl. | Scenario 2 Add agricultural threshold 250 mg/Cl. | Scenario 3 Add agricultural threshold 150 mg/Cl. | Scenario 4 Add agricultural threshold 50 mg/Cl. |
Emek Heffer | ||||
379 | 381 | 273 | 52 | |
Western Aquifer | 75 | 76 | 84 | 50 |
Eastern Aquifer | 139 | 145 | 151 | 50 |
Eastern | 28 | 28 | 28 | 34 |
Entire Emek Heffer | 88 | 92 | 91 | 45 |
1492 | 1522 | 918 | 314 | |
Western Aquifer | 283 | 327 | 195 | 63 |
Eastern Aquifer | 411 | 333 | 189 | 53 |
Eastern | 72 | 72 | 72 | 54 |
Entire | 243 | 233 | 142 | 57 |
Chloride concentration in irrigation water (mg/Cl) for a steady-state aquifer salinity threshold of 250 mg/Cl.
So far, we have seen the implications of lowering or increasing the permitted threshold on the state of the aquifer. From these results we might conclude that a policy of strict thresholds level is preferable. However, this kind of policy comes at a cost; in the following sections we demonstrate the financial implications of the different salinity thresholds.
The average cost of desalination under representative initial conditions is shown in Table 7. Based on the relevant alternatives for the Emek Heffer area, the cost of brackish water desalination is 36 cents per cubic meter (cm); the cost of national carrier water desalination is 29.4 cents/cm (depending, in practice, on the size of the plant); the cost of wastewater desalination is 41.6 cents/cm and the cost of seawater desalination is 54.2 cents/cm (again, the cost depends on the size of the plant; these calculations were done for a plant size of 50 mcm/year).
Brackish | National carrier | Wastewater | Seawater | |
Infrastructure | 13.0 | 14.6 | 3.3 | 32.5 |
Desalination | 23.0 | 14.8 | 38.3 | 21.7 |
Total | 36.0 | 29.4 | 41.6 | 54.2 |
Average cost of desalination (cents per cm).
The economic component of the model is used to estimate the total costs of water supply for each area for the different scenarios. The inputs for this component are the outputs of the previously described components: From the planning component results we took the water sources as inputs for the economic component; from the hydrological component we took the predictions of chloride concentration over time; and from the technological component we took the average costs of desalination for each potential source of water supply (groundwater, which is brackish water, national carrier water, wastewater and seawater).
The results of the economic component for the entire area of Emek Heffer are presented in the following tables. The total net present value (that is, the total economic value translated into today\'s economic value) is presented in Table 8, and the annual costs under steady-state conditions are shown in Table 9, for each one of the scenarios (except for the scenario of irrigation with highly saline water, which is not likely to be used as an actual policy option).
The results in Table 8 show that under scenario 1 (urban water salinity threshold of 250 mg/Cl), the net present cost of the water supply ranges from 95.19 million dollars for brackish water (groundwater) desalination to 96.44 million dollars for seawater desalination. In scenario 2 (urban and agricultural water salinity thresholds of 250 mg/Cl), the net present cost ranges from 101.08 million dollars for groundwater desalination, 177.69 million dollars for wastewater desalination and up to 207.09 million dollars for seawater desalination. In scenario 3 (salinity thresholds of 150 mg/Cl) the net present cost ranges from 120.58 million dollars for groundwater desalination, 216.71 million dollars for wastewater desalination and up to 353.49 million dollars for seawater desalination. In scenario 4 (salinity thresholds of 50 mg/Cl) the net present cost ranges from 219.19 million dollars for groundwater desalination, 246.70 million dollars for wastewater desalination and up to 392.47 million dollars for seawater desalination. In all of the scenarios, the lowest desalination costs were for National Carrier water, followed by groundwater, wastewater and seawater. We should note that seawater desalination is mostly meant to increase the total water supply available, so the cost of their desalination for improving the water quality includes only the additional costs.
Scenario | 1 | 2 | 3 | 4 | 5 |
Desalinated water source | Urban threshold | Urban & agricultural thresholds | Medium-level salinity threshold | Low-level salinity threshold | No irrigation with wastewater |
Brackish (groundwater) | 95.19 | 101.06 | 120.58 | 219.19 | 129.57 |
Cost increase | - | 5.87 | 19.52 | 95.61 | - |
Wastewater | - | 177.69 | 216.71 | 246.70 | - |
Seawater | 96.44 | 207.09 | 353.49 | 392.47 | 132.36 |
Net present value of the cost for 100 years (million dollars).
In comparing between the scenarios, we can see that improving the salinity threshold from 250 mg/Cl for urban use alone to 250 mg/Cl for agricultural water use as well involves an increase in the total net present cost of water supply to the Emek Heffer area by 5.87 million dollars. Introducing the stricter condition of 150 mg/Cl involves an increase in cost of 19.52 million dollars, and the strictest threshold scenario of 50 mg/Cl involves the relatively high increase in cost of 98.61 million dollars.
The results in Table 9 show that under scenario 1 the annual cost ranges from 4.98 million dollars for groundwater desalination up to 5.26 million dollars a year for seawater desalination. Under the conditions of scenario 2, the annual cost ranges from 5.54 million dollars for groundwater desalination to 8.96 million dollars for wastewater desalination and up to 15.52 million dollars for seawater desalination. Under scenario 3, the annual cost ranges from 7.55 million dollars for groundwater desalination, 10.40 million dollars for wastewater desalination and up to 17.03 million dollars for seawater desalination. Under scenario 5, the annual cost ranges from 10.63 million dollars for groundwater desalination, 11.83 million dollars for wastewater desalination and up to 18.83 million dollars for seawater desalination. Again, in all of the scenarios examined, the lowest desalination costs were for National Carrier water, followed by groundwater, wastewater and seawater.
The comparison between the scenarios shows that improving the salinity threshold from 250 mg/Cl for urban use alone to 250 mg/Cl for agricultural water use as well involves an increase in the annual cost of the water supply to the Emek Heffer area by 0.56 million dollars. Introducing the stricter condition of 150 mg/Cl involves an increase in cost of 2.57 million dollars, and the strictest threshold scenario of 50 mg/Cl involves the relatively high cost increase of 5.65 million dollars. Maintaining a salinity threshold level of 250 mg/Cl for the aquifer water involves an annual cost ranging from 9.9 to 13.29 million dollars.
Scenario | 1 | 2 | 3 | 4 | 5 |
Desalinated water source | Urban threshold | Urban & agricultural thresholds | Medium-level salinity threshold | Low-level salinity threshold | No irrigation with wastewater |
Brackish (groundwater) | 4.98 | 5.54 | 7.55 | 10.63 | 7.09 |
Cost increase | - | 0.56 | 2.57 | 5.65 | - |
Wastewater | - | 8.96 | 10.40 | 11.83 | - |
Seawater | 5.26 | 15.52 | 17.03 | 18.83 | 11.62 |
Maintaining aquifer threshold level | 9.90 | 9.82 | 11.06 | 13.29 | 10.65 |
Cost increase | 4.92 | 4.28 | 3.51 | 2.66 | 3.56 |
Annual cost under steady-state conditions (million dollars).
Compared with the threshold of 250 mg/Cl for urban water use alone, the net present value of the cost increase involved in a policy of a 150 mg/Cl threshold for urban and agricultural water use is 27.64 million dollars, and for a threshold of 50 mg/Cl the cost increase is 126.25 million dollars (Table 8). The increase in the annual cost under a steady-state condition for a threshold of 150 mg/Cl for urban and agricultural water is 3.13 million dollars, and for a threshold of 50 mg/Cl – 8.78 million dollars. The total water quantity in question is 24.6 mcm, meaning that the annual increase in cost per cm for improving the threshold for urban and agricultural water to 150 mg/Cl and 50 mg/Cl is 12.5 and 35.5 cents per cm, respectively. It should be noted that determining a threshold of 50 mg/Cl involves a relatively large increase in costs.
Maintaining a threshold of 250 mg/Cl for the aquifer water involves an annual cost increase of 2.66 to 4.92 million dollars, compared with the lowest cost for the same scenario without the condition of maintaining the aquifer water salinity threshold. That means that the increase in annual cost per cm for maintaining a sustainable aquifer, with a salinity level of 250 mg/Cl under a steady-state conditions, ranges from 10.8 to 20 cents/cm.
The Israeli water sector is currently under conditions of water shortage, and at the stage of planning and establishing seawater desalination plants. At the same time, farmers have been moving to extensive use of wastewater for irrigation, which enables a significant reduction of the demand for freshwater for irrigation, as well as providing a practical solution for wastewater disposal. However, the problem of wastewater salinity should be addressed. The use of wastewater and desalinated seawater provide a partial solution for the problem of water shortage, but the impact on the deterioration of groundwater quality, as expressed in the increase in salinity levels, cannot be ignored. We have presented alternatives for water desalination in order to improve their quality and found that desalinating groundwater and wastewater can be done at a relatively low cost, although some technological and administrative issues remain to be addressed. Both issues of the quality of the water supply and the sustainability of the aquifer are important in the short term as well as in the long term. This research presents the additional costs of stricter salinity threshold levels that will help maintain a sustainable aquifer. Policy makers would need to weigh these additional costs against the added benefits.
We developed an hydrological model for planning the water supply from different sources and predicting the chloride concentrations in the aquifer water, and implemented it on a unique database constructed for the case study of the hydrological cells of the Emek Heffer and Northern Sharon areas in Israel. We also estimated the costs of various desalination processes under these regional conditions, and calculated the total cost of the water supply for different policy-making scenarios.
Several findings arise from calculating the costs involved in improving the salinity threshold for water supply to the city and/or agriculture, or for maintaining a sustainable steady-state aquifer. The main conclusions are that the lowest-cost alternative is brackish water desalination; desalination of national carrier water is feasible under large-scale use conditions; wastewater desalination is important to maintain the agricultural water salinity threshold; and finally, seawater desalination is worthwhile when their contribution is essential for the national water balance. If we wish to maintain a salinity threshold of 250 mg/Cl in the aquifer water, we need to limit the salinity level of the irrigation water in Emek Heffer to approximately 90 mg/Cl. The additional annual expenditure needed to maintain the aquifer salinity level is between 2.5 to 5 million dollars, or between 10.75 to 20 cents per cm. It is important to keep in mind that improving the quality of the water supply and the quality of the groundwater comes at an economic price that has to be taken into consideration in the decision making process.
The model we developed and applied is used to examine the planning, hydrological, technological and economic aspects of the supply and desalination of different water sources, and to examine the implications on the economy, on groundwater quality and on the environment. The model\'s advantages lie in its multidisciplinary nature and in its practical applicability, as well as in its ability to evaluate and direct scenarios of supply and treatment of different water sources. At this stage, the model includes only the salinity level component of water quality, but the model can be expanded to examine the treatment of other components, such as nitrogen concentrations, and can be developed as a computerized model that will improve the policy-makers ability to make informed decisions.
Oral cancer remains as a significant cause of mortality worldwide as most of these the tumors are detected and treated in late stages. The etiology of oral cancer is multifactorial. Tobacco and alcohol are still considered the main risk factors as about 80% of the patients who develop oral tumors are tobacco and/or alcohol users [1]. Additional etiologic factors have also been suggested such as infection by human papillomavirus (HPV) and other oncogenic viruses, immunosuppression states, genetic alterations, and deficient nutrition.
Dental implants are one of the top choices for the oral rehabilitation of partially or totally edentulous patients. The stability and comfort provided by the implants-anchored crowns are among their clinical advantages. Moreover, the success rate of dental implants surpasses 94.6% [2]. However, the soft tissue and supporting structures around the dental implants remain exposed to the oral cavity and may undergo pathological changes. The most frequent lesions are those of inflammatory nature triggered by the accumulation of bacterial biofilm. When the inflammatory lesion is confined to the soft tissue, it is named as peri-implant mucositis. On the other hand, when there is loss of supporting bone, the lesion is known as peri-implantitis. Due to the high incidence of peri-implant inflammatory diseases, some dental professionals treat the lesion but do not send the specimens to the microscopical analysis. About 3.6% of the lesions are malignant tumors (mainly squamous cell carcinomas, the most common malignancy of the oral cavity) [3]. In 2001, the first cases of malignant lesions developing around dental implants were published [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. Since then, the potential relationship of titanium implants with malignant tumor development has been discussed [1, 5, 13].
The aim of this chapter was to offer the readership the most recent information regarding the clinical features of oral cancer around dental implants, its differential diagnosis, and potential oncogenic mechanisms.
A review of literature available until September 2021 was conducted in the PubMed/Medline database using the term “Oral squamous cell carcinoma around dental implants.” Only cases with definitive microscopic diagnosis of OSCC arising in the soft tissue around one or more dental implants were included. The literature review revealed 43 cases of patients with OSCC around dental implants in the 19 published manuscripts [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. All clinical and epidemiological information about the sample is summarized in the Table 1.
Author | Gender/age | Cancer site | Lesion | Risk factors* | Prev. Rep. CA | Primary diagnosis |
---|---|---|---|---|---|---|
Block et al. 2001 [4] | M/72 | Mandible | Mimicked PI | Yes | Yes | PI |
Shaw et al. 2004 [5] | M/67 | Mandible | Exophytic mass | NA | Yes | PI |
F/69 | Mandible | Mimicked PI | NA | Yes | NA | |
Czerninski et al. [15] | F/52 | Mandible | Mimicked PI | Yes | No | PI |
M/80 | Mandible | Mimicked PI | No | Yes | PI | |
Abu El Naaj [16] | F/70 | Mandible | Exophytic white | No | Yes | NA |
Schache el al. [17] | F/77 | Mandible | Exophytic mass | No | No | NA |
Gallego et al. [18] | F/81 | Mandible | PI mass | No | Yes | OL |
Kwok et al. [19] | M/71 | Mandible | “Inflammatory process” | Yes | No | PI |
F/67 | Mandible | Exophytic mass | Yes | Yes | NA | |
M/62 | Mandible | Non-healing ulcer | Yes | No | Na | |
De Ceulaer et al. [20] | F/77 | Mandible | Mimicked PI | Yes | Yes | PI |
M/71 | Mandible | Swelling | Yes | Yes | PI | |
F/62 | Mandible | Mimicked PI | Yes | Yes | PI | |
Meijer et al. [21] | F/69 | Mandible | Exophytic mass | No | Yes | PI |
Orhan et al. [22] | F/69 | Mandible | Numb chin syndrome, with mixed RO-RL lesion | NA | Yes | NA |
Pfammatter et al. [6] | F/55 | Mandible | mimicked PI, numbness | Na | Yes | Metastasis |
Moergel et al. [7] | F/63 | Mandible | Exophytic mass | No | Yes | NA |
F/70 | Mandible | Exophytic mass | Yes | Yes | NA | |
M/72 | Mandible | Exophytic mass | No | Yes | NA | |
M/57 | Mandible | mimicked PI | Yes | Yes | PI | |
M/72 | Mandible | Exophytic mass | NA | No | NA | |
F/54 | Mandible | Exophytic mass | No | NA | NA | |
M/47 | Mandible | Ulcer | Yes | No | NA | |
M/88 | Mandible | Ulcer | No | No | NA | |
F/42 | Mandible | Ulcer | NA | Yes | NA | |
F/59 | Mandible | Ulcer | NA | Yes | NA | |
M/73 | Maxilla | Exophytic mass | Yes | Yes | NA | |
M/77 | Mandible | Exophytic mass | Yes | No | NA | |
F/68 | Mandible | Exophytic mass | Yes | Yes | NA | |
F/69 | Mandible | Exophytic mass | No | Yes | NA | |
Marini et al. [8] | F/51 | Mandible | Exophytic mass | No | No | PI |
Bhandari et al. [9] | F/71 | Maxilla | Erythematous | No | No | PI |
Chainani-Wu et al. [10] | F/60 | Maxilla | Fistula | No | No | PI |
Vadim Raiser et al. [11] | F/55 | Maxilla | White Exophytic mass | NA | NA | OL |
F/70 | Mandible | Erythematous mass | NA | NA | NA | |
Noguchi et al. [12] | F/65 | Mandible | gingival swelling | Yes | NA | Neoplasia |
Malthiéry et al. [13] | M/77 | Mandible | Mimicked PI | NA | No | PI |
Granados et al. [14] | M/83 | Mandible | Ulcerous lesion | NA | Yes | NA |
M/60 | Mandible | Verrucous lesion | NA | NA | NA | |
F/54 | Mandible | “Gum lesion” | NA | NA | NA | |
M/64 | Mandible | Excrescent lesion | NA | NA | NA |
Demographic and clinical features of patients diagnosed with oral squamous cell carcinoma around dental implants.
M = Male; F = Female; Pre.Rep.CA = Previously reported cancer; PI = Peri-implantitis; OL = Oral lichen planus; NA = Not available. * Patients who smokers and/or drinkers were considered.
The age of patients with oral cancer around dental implants ranged from 61 to 75 years old. There was a predominance of females (24 cases - 57.14%) when compared to males (18 cases - 42.86%). The typical clinical appearance of oral cancer around dental implants was an exophytic mass (20 tumors—47.62%) with few cases presenting as ulcer (4 tumors—9.52%). The bone osteolysis was frequently observed in the area of tumor causing the implant loss in some patients. The tumors affected mainly mandible (38 cases—90.47%) of the patients with multiples osseointegrated implants. Of note, oral cancer around dental implants is frequently clinically mistaken as peri-implantitis (Table 1).
Although peri-implantitis is the most common local risk factor for dental implant failure, the development of oral cancer involving the soft tissue around the titanium also impact the quality of life of the patient negatively. The oral cancer can manifest as hypertrophy, erythema, and/or ulcerative lesion of the soft tissue, and these features are similar to inflammatory peri-implant diseases such as peri-implantitis and/or peri-implant mucositis, as described by others [7, 10, 11]. Furthermore, these inflammatory peri-implant diseases frequently present the same epidemiological pattern and risk factors for oral cancer, that is, patients older than 60 years old and chronic tobacco and/or alcohol consumers [1]. Although there are protocols for peri-implantitis treatment, frequently, the peri-implant tissue removed during this surgical treatment is not submitted for histopathological analysis [23, 24]. Then, the number of reported cases of peri-implant malignancy seems to be low in mouth but it may be being underreported by health professionals [24]. Recently, in a study of 111 biopsies of peri-implant lesions, 3.6% of those had histopathological diagnosis of oral squamous cell carcinomas [3]. Another investigation demonstrated that 2.9% of 68 dental implant-related lesions were oral squamous cells carcinomas [25].
Figure 1 illustrates a case report of an edentulous 64-year-old woman. She had an exophytic mass associated with ulcerated area and covered by a yellowish membrane in the anterior region of the mandible. The lesion was surrounded multiple osseointegrated implants (Figure 1A). She did not report adverse habits, for example, tobacco or alcohol consumption. Periapical radiographic exhibited an ill-defined bone destruction underneath the area of the lesion (Figure 1B). The histopathological analysis exhibited keratinizing well-differentiated epithelial neoplastic cells, some undergoing atypical mitosis, and invading the subjacent fibrous connective tissue (Figure 1C). The diagnosis of oral cancer was confirmed.
Clinical and microscopic findings of oral squamous cell carcinoma around dental implants. a) Exophytic ulcer covered by necrotic tissue at the anterior-inferior alveolar ridge.b) Periapical radiograph showing an ill-defined bone loss in the peri-implant region. c) Neoplastic squamous epithelium-infiltrating subjacent submucosa with corneal pearls and discrete pleomorphism. d and e) epithelial cells with atypical mitotic figures infiltrating the tissue.
The early diagnosis of malignant tumors around dental implants is challenging because incipient lesions may resemble inflammatory peri-implant lesions [1, 2, 4, 5, 6, 7, 10, 12, 15, 16, 17, 18, 21]. In the Table 1, 14 out of 43 cases of oral cancer surrounding dental implants (33.33%) had the primary diagnosis of peri-implant lesions. Therefore, this clinical misinterpretation might delay the diagnosis of oral cancer facilitating its dissemination and resulting in a worst prognosis of the disease. These facts underscore how critical is the histological exam of every lesion around dental implants surgically removed. Furthermore, the peri-implant lesion that does not present the classical features of an inflammatory condition and that does not respond to conventional treatment, particularly if the patient has risk factor for oral cancer, should be submitted to the biopsy and histopathological analysis [23, 24, 25].
The etiology of oral cancer is multifactorial. OSCC is the most prevalent oral malignant tumor and it is associated with lifestyle risk factors such as alcohol consumption and smoking [26]. Curiously, tobacco smoking is also the predictor of dental implants failure and more smokers have post-operative infections and peri-implant crestal bone loss than nonsmokers [27, 28]. Although the information about lifestyle-related factors that predispose to oral cancer was incomplete in most of cases included in the Table 1, 34.88% of patients diagnosed with squamous cell carcinoma around dental implants were smokers and/or drinkers. These overlapping risk factors may drive the clinician to attribute the onset of an atypical lesion involving dental implants to a deficient or anomalous immune response of a patient who consumes tobacco and/or alcohol. However, it is essential that the clinicians are aware that the classic signs of inflammation persist in such patients and that these features are useful to distinguish a benign from a malignant lesion. Additionally, the histopathological analysis remains as the gold standard for the diagnosis of lesions located in the oral cavity [23].
A well-defined concept is that patients with previous history of cancer have higher risk of developing other tumors. Twenty-three (54.76%) of all cases of squamous cell carcinoma around dental implants arose in patients with history of cancer. Interestingly, we observed that 19 (82.60%) patients had OSCC previously. Furthermore, other patients had lung [6, 15], intestine [15], thyroid [17], and breast [17, 22] cancer previously. As the development of OSCC has been also associated with genomic instability and genetic predisposition [1], one can hypothesize that a patient who had a malignant lesion are more susceptible to local aggressions such as the contact of the soft tissue with dental implant materials.
Titanium is one of the most common components in implants alloys used in dental and medical fields [1, 29]. High biocompatibility, appropriate mechanical properties, inertness, and corrosion resistance are among the main advantages of titanium [25, 29, 30]. When the titanium implant is installed in extra oral sites, where it is protected from the contact with the environment, it has inert behavior. On the other hand, dental implants are continuously exposed to the oral cavity hostile conditions [31]. The area between the implants and the abutment or the prosthetic crown is particularly susceptible to the bacterial biofilm accumulation, saliva, pH and temperature changes, and functional micromotion (Figure 2) [31].
Illustration of potential risk factors and mechanisms on the development of squamous cell carcinoma around dental implants.
When the dental implant surface is exposed to any source of oxygen or nitrogen, a chemical reaction takes place and a thin layer of titanium dioxide (TiO2) is formed and deposited in the outer surface of the implants. This layer is extremely resistant to corrosion. However the chemical agents of the oral cavity can reduce the protection of the dioxide deposit and induce the corrosion development [31]. Saliva and other chemicals introduced into the oral cavity through feeding or in contact with bacterial biofilms influence the gradual biodegradation of metallic structures including the titanium used in dental implants [29]. Furthermore, acidic solution combined with mechanical friction strength potentiates the damages to the implants surfaces. Interestingly, some studies with cytology have demonstrated the presence of titanium particles in the peri-implant tissues [23, 25] regardless of the presence of peri-implantitis or peri-implant mucositis. It has been suggested that this material accumulation may be the result of the corrosive process of the dental implants [29, 30, 32], implant-abutment friction at the installation of the implants, and/or implantoplasty [29, 31, 33, 34]. The degree of titanium corrosion can be influenced by quality and quantity of saliva, diet, alloy polishing, genetics, oral hygiene, amount and distribution of the occlusal forces, and microbiota [29, 30, 32].
The above data show that titanium is not entirely bioinert as suggested years ago. Then, even with their good biological properties, titanium alloys are susceptible to corrosion attack with release of metal ions to the surrounding hard and soft oral tissues, lymph nodes, peripheral, and even distant organs [30]. Consequently, titanium ions have been implicated in the development of oral cancer around dental implants [1, 34].
As stated previously, the relationship between titanium dental implants and oral cancer has been suggested based on the increasing number of tumors arising in the peri-implant tissue. However, as far as we know, there is not any study dedicated to unveil the potential carcinogenic mechanisms triggered by titanium ions.
Titanium particles have been shown to induce the expression of breast cancer gene 1 (BRCA1) and checkpoint kinase 2 (CHK2) in epithelial cells
In 2006, the International Agency for Research on Cancer (IARC) classified the titanium dioxide as a possible carcinogen for humans [41]. However, in view of the few case reports of oral cancer around dental implants the authors were unable to exclude the existence of other confounding carcinogens as tobacco and/or alcohol [1, 7, 19].
The literature review showed that most cases of OSCC around dental implants had initial clinical features compatible with peri-implantitis. Therefore, this clinical misinterpretation of an inflammatory process in peri-implant mucosa may delay the diagnosis of oral cancer facilitating the local progression and dissemination of cancer cells, resulting in worst patient’s prognosis. Thus, the peri-implant lesion not responding to conventional anti-inflammatory treatment, particularly if the patient has risk factor for oral cancer, should be submitted to the biopsy and histopathological analysis, avoiding delay in the diagnosis of the tumor.
This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code (#001). We also thank Dr. Marcelo Júnior Zanda for providing the clinical images.
The authors declare they do not have conflict of interest.
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However, recent reports have revealed that the use of veterinary drugs in large amounts and consistently could result in deposition of antimicrobial residues in muscle and organs of animal. Consumption of these residues in animal products may pose health risk to consumers including development of antibiotic resistance bacteria, allergy, reproductive disorder and hypersensitivity reaction. It is in line with this that this chapter seeks to examine the cause, occurrence, mode of detection, health implication and possible solution to veterinary drugs residues in meat and meat products.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Andrew Bamidele Falowo and Oluwakamisi Festus Akimoladun",authors:[{id:"271285",title:"Dr.",name:"Andrew",middleName:"Bamidele",surname:"Falowo",slug:"andrew-falowo",fullName:"Andrew Falowo"},{id:"288263",title:"Mr.",name:"Oluwakamisi Festus",middleName:null,surname:"Akimoladun",slug:"oluwakamisi-festus-akimoladun",fullName:"Oluwakamisi Festus Akimoladun"}]},{id:"66512",doi:"10.5772/intechopen.84888",title:"Veterinary Pharmaceuticals and Antimicrobial Resistance in Developing Countries",slug:"veterinary-pharmaceuticals-and-antimicrobial-resistance-in-developing-countries",totalDownloads:1569,totalCrossrefCites:10,totalDimensionsCites:18,abstract:"Veterinary pharmaceuticals include a wide range of anti-infectives and additives in the use for animal health, nutrition, reproduction, and productivity. Antimicrobials are among the most extensively used drugs in developing countries largely due to large population of livestock and the burden of infectious diseases. The introduction of penicillin in 1943 and other antibiotics thereafter provided remedies for many infections in humans and animals, reducing mortality and productivity losses. Since then, a repertoire of antibiotics and antimicrobials has been introduced as chemotherapeutics and/or prophylaxis. This success notwithstanding, many pathogens of consequences are no longer susceptible owing to emergence of antimicrobial-resistant (AMR) microorganisms. This has made treatment of infectious diseases less effective. Beside spontaneous emergence of mutant microorganisms, scientists are wary of AMR caused by intensive use of antibiotics in humans and animals, sometimes in subtherapeutic doses as preventive medicine. In developing countries, environmental exposure and persistent use of antibiotics in food animals may leave residues in the food chain. The consequences include development of AMR. In this chapter, we reviewed antimicrobial use in veterinary medicine and sequela in the emergence of AMR and described the imperative of antimicrobial stewardship in veterinary practice to combat AMR in developing countries.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Meseko Clement, Makanju Olabisi, Ehizibolo David and Muraina Issa",authors:[{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko"}]},{id:"69693",doi:"10.5772/intechopen.82243",title:"Overview of Canine Babesiosis",slug:"overview-of-canine-babesiosis",totalDownloads:1366,totalCrossrefCites:5,totalDimensionsCites:10,abstract:"Canine babesiosis is a tick-borne, protozoal, haemoparasitic disease that can cause varying degrees of haemolytic anaemia, splenomegaly, thrombocytopenia and fever. There are two hosts for the transmission of Babesia spp., viz. invertebrate (tick) and vertebrate host. Dogs are one among the many targets of Babesia spp., causing canine babesiosis, and now there are clinical evidences of possible vertical transmission too. Dogs of all ages can be affected with Babesia spp., but young puppies are more commonly affected. Considering advanced diagnostic techniques, for an early and specific detection of acute infections, an AgELISA that is potentially translatable to a rapid diagnostic test design is reported. Different molecular techniques used for identification and differentiation of the various species of Babesia are semi-nested PCR, reverse line blotting and PCR-restriction fragment length polymorphism analysis. Treatment consists of three components: treatment with antiprotozoal agents to eliminate the parasite, blood transfusions to treat severe anaemia and supportive care for the complications and metabolic derangements. Blood lactate concentrations can serve as a prognostic indicator in severe or complicated canine babesiosis. For prevention apart from conventional measures, vaccines against Babesia species such as B. gibsoni are currently being developed.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Poonam Vishwakarma and M.K. Nandini",authors:[{id:"267230",title:"Dr.",name:"Poonam",middleName:null,surname:"Vishwakarma",slug:"poonam-vishwakarma",fullName:"Poonam Vishwakarma"},{id:"267243",title:"Dr.",name:"Nandini",middleName:null,surname:"M. K",slug:"nandini-m.-k",fullName:"Nandini M. 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However, recent reports have revealed that the use of veterinary drugs in large amounts and consistently could result in deposition of antimicrobial residues in muscle and organs of animal. Consumption of these residues in animal products may pose health risk to consumers including development of antibiotic resistance bacteria, allergy, reproductive disorder and hypersensitivity reaction. It is in line with this that this chapter seeks to examine the cause, occurrence, mode of detection, health implication and possible solution to veterinary drugs residues in meat and meat products.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Andrew Bamidele Falowo and Oluwakamisi Festus Akimoladun",authors:[{id:"271285",title:"Dr.",name:"Andrew",middleName:"Bamidele",surname:"Falowo",slug:"andrew-falowo",fullName:"Andrew Falowo"},{id:"288263",title:"Mr.",name:"Oluwakamisi Festus",middleName:null,surname:"Akimoladun",slug:"oluwakamisi-festus-akimoladun",fullName:"Oluwakamisi Festus Akimoladun"}]},{id:"26133",title:"Creation of New Local Anesthetics Based on Quinoline Derivatives and Related Heterocycles",slug:"creation-of-new-local-anesthetics-based-on-quinoline-derivatives-and-related-heterocycles",totalDownloads:3283,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"761",slug:"pain-management-current-issues-and-opinions",title:"Pain Management",fullTitle:"Pain Management - Current Issues and Opinions"},signatures:"Igor Ukrainets",authors:[{id:"88171",title:"Dr.",name:"Igor",middleName:null,surname:"Ukrainets",slug:"igor-ukrainets",fullName:"Igor Ukrainets"}]},{id:"26152",title:"Non-Pharmacological Therapies in Pain Management",slug:"non-pharmacological-therapies-in-pain-management",totalDownloads:59099,totalCrossrefCites:7,totalDimensionsCites:20,abstract:null,book:{id:"761",slug:"pain-management-current-issues-and-opinions",title:"Pain Management",fullTitle:"Pain Management - Current Issues and Opinions"},signatures:"Yurdanur Demir",authors:[{id:"80570",title:"Dr.",name:"Yurdanur",middleName:null,surname:"Demir",slug:"yurdanur-demir",fullName:"Yurdanur Demir"}]},{id:"63964",title:"Antimicrobial Usage and Resistance in Dairy Cattle Production",slug:"antimicrobial-usage-and-resistance-in-dairy-cattle-production",totalDownloads:1022,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Antimicrobial resistance (AMR) has been a public health threat globally, with millions of lives lost due to AMR infections each year. The cases of AMR continue to escalate and cause devastating effect to both humans and animals. AMR contributes to high morbidity and mortality of the livestock, which results in staggering economic losses to the livestock producers. The main factor for AMR to arise in this industry is mainly due to the eagerness of livestock producers to meet high demand by using antimicrobials to promote animal growth and disease prevention. From a public health perspective, AMR in dairy cattle can also jeopardize human population due to the potential dissemination of AMR pathogens to humans via consumption of infected dairy products or direct contact with infected dairy cattle. At the current rate of unrestricted antimicrobial usage, AMR will be expedited and soon we will run out of effective treatment for even the simplest infection. World Health Organization (WHO) has issued a set of guidelines for the use of medically important antimicrobials on animals to mitigate the adverse consequences of AMR on human. Thus, this chapter will explain antimicrobial usage in dairy cattle production and the recent approaches and challenges on AMR.",book:{id:"8634",slug:"veterinary-medicine-and-pharmaceuticals",title:"Veterinary Medicine and Pharmaceuticals",fullTitle:"Veterinary Medicine and Pharmaceuticals"},signatures:"Enli Loo, Kok Song Lai and Rozaihan Mansor",authors:[{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai"},{id:"240934",title:"Dr.",name:"Rozaihan",middleName:null,surname:"Mansor",slug:"rozaihan-mansor",fullName:"Rozaihan Mansor"},{id:"264957",title:"Mr.",name:"Loo",middleName:null,surname:"Enli",slug:"loo-enli",fullName:"Loo Enli"}]}],onlineFirstChaptersFilter:{topicId:"1193",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. 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His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. 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He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null}]},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. 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He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. 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He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. 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Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. 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He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:6,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. 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