Authors, Participants, and Objective of the study.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10349",leadTitle:null,fullTitle:"Environmental Health",title:"Environmental Health",subtitle:null,reviewType:"peer-reviewed",abstract:"Environmental Health discusses environmental effects on human health. It examines heavy metal pollution, biological effects of arsenic (on reproductive health, especially), effects of soil organic carbon, chemical pollution of drinking water, climate change and vector-borne diseases, marine fuels, particulate matter, and the United Nations Sustainable Development Goals (SDGs).",isbn:"978-1-83968-721-1",printIsbn:"978-1-83968-720-4",pdfIsbn:"978-1-83968-722-8",doi:"10.5772/intechopen.91535",price:119,priceEur:129,priceUsd:155,slug:"environmental-health",numberOfPages:256,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"daa4fa476e1d64c56fabfdbf670e7a9b",bookSignature:"Takemi Otsuki",publishedDate:"December 15th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10349.jpg",numberOfDownloads:3352,numberOfWosCitations:0,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:8,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:14,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 7th 2020",dateEndSecondStepPublish:"December 10th 2020",dateEndThirdStepPublish:"February 8th 2021",dateEndFourthStepPublish:"April 29th 2021",dateEndFifthStepPublish:"June 28th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"34101",title:"Prof.",name:"Takemi",middleName:null,surname:"Otsuki",slug:"takemi-otsuki",fullName:"Takemi Otsuki",profilePictureURL:"https://mts.intechopen.com/storage/users/34101/images/system/34101.jpg",biography:"Honor. Prof. Takemi Otsuki graduated from Kawasaki Medical School (KMS), Kurashiki, Japan, in 1981. In 1986, at the Institutes of Medical Science, University of Tokyo, he was involved in clinical and experimental research in bone marrow transplantation. The theme of the post-doctoral school (1985–1989) was myeloma cell biology. After joining the Department of Hematology, University of Minnesota, USA, in 1992, Dr. Otsuki studied genes involved in chromosomal translocations of lymphomas in the Department of Hematopathology, US National Cancer Institute, National Institutes of Health. He returned to the Department of Hygiene, KMS, in 1996 and become a professor there in 2003. After retiring from KMS and obtaining an honorary professorship, Dr. Otsuki began working at the Shinjo Village National Health Insurance Clinic. Shinjo village has a small population of fewer than 900 people, and Dr. Otsuki is the sole medical doctor there.",institutionString:"Kawasaki Medical School",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Kawasaki Medical School",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"129",title:"Environmental Health",slug:"environmental-sciences-environmental-health"}],chapters:[{id:"74825",title:"Land Use Change Affects Soil Organic Carbon: An Indicator of Soil Health",doi:"10.5772/intechopen.95764",slug:"land-use-change-affects-soil-organic-carbon-an-indicator-of-soil-health",totalDownloads:451,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Soil organic carbon (SOC) is a major indicator of soil health. Globally, soil contains approximately 2344 Gt of organic carbon (OC), which is the largest terrestrial pool of OC. Through plant growth, soil health is connected with the health of humans, animals, and ecosystems. Provides ecosystem services which include climate regulation, water supplies and regulation, nutrient cycling, erosion protection and enhancement of biodiversity. Global increase in land use change from natural vegetation to agricultural land has been documented as a result of intensification of agricultural practices in response to an increasing human population. Consequently, these changes have resulted in depletion of SOC stock, thereby negatively affecting agricultural productivity and provision of ecosystem services. This necessitates the need to consider technological options that promote retention of SOC stocks. Options to enhance SOC include; no-tillage/conservation agriculture, irrigation, increasing below-ground inputs, organic amendments, and integrated, and diverse cropping/farming systems. In addition, land use conversion from cropland to its natural vegetation improves soil C stocks, highlighting the importance of increasing agricultural production per unit land instead of expanding agricultural land to natural areas.",signatures:"Lucy W. Ngatia, Daniel Moriasi, Johnny M. Grace III, Riqiang Fu, Cassel S. Gardner and Robert W. Taylor",downloadPdfUrl:"/chapter/pdf-download/74825",previewPdfUrl:"/chapter/pdf-preview/74825",authors:[{id:"246475",title:"Dr.",name:"Lucy",surname:"Ngatia",slug:"lucy-ngatia",fullName:"Lucy Ngatia"},{id:"256676",title:"Prof.",name:"Robert",surname:"Taylor",slug:"robert-taylor",fullName:"Robert Taylor"},{id:"266289",title:"Dr.",name:"Daniel",surname:"Moriasi",slug:"daniel-moriasi",fullName:"Daniel Moriasi"},{id:"344365",title:"Dr.",name:"Johnny",surname:"Grace Iii",slug:"johnny-grace-iii",fullName:"Johnny Grace Iii"},{id:"344366",title:"Dr.",name:"Riqiang",surname:"Fu",slug:"riqiang-fu",fullName:"Riqiang Fu"},{id:"344367",title:"Dr.",name:"Cassel",surname:"Gardner",slug:"cassel-gardner",fullName:"Cassel Gardner"}],corrections:null},{id:"74161",title:"Evaluating the Clinical and Cost Effectiveness of Musculoskeletal Digital Health Solutions",doi:"10.5772/intechopen.94841",slug:"evaluating-the-clinical-and-cost-effectiveness-of-musculoskeletal-digital-health-solutions",totalDownloads:275,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter will introduce the clinician to the quickly expanding field of musculoskeletal-focused digital apps (MDA), with an eye towards helping the clinician select and recommend MDAs for optimal patient care. MDAs are increasingly being used for physical therapy and rehabilitation, telehealth, pain management, behavioral health, and remote patient monitoring. The COVID-19 pandemic has vastly accelerated the adoption of telehealth and digital health apps by patients and clinicians, and the digital health field will only continue to expand as developers increasingly harness artificial intelligence (AI) and machine learning (ML) capabilities, coupled with precision medicine capabilities that integrate personal health data tracking and genomics insights. Here we begin with an overview of several types of MDA, before discussing the epidemiology of musculoskeletal conditions and injuries, clinical considerations in selecting a digital health solution, payor reimbursement for digital apps, and regulatory oversight of digital health apps.",signatures:"Glen Cheng, Nischal Chennuru and Liz Kwo",downloadPdfUrl:"/chapter/pdf-download/74161",previewPdfUrl:"/chapter/pdf-preview/74161",authors:[{id:"330919",title:"M.D.",name:"Liz",surname:"Kwo",slug:"liz-kwo",fullName:"Liz Kwo"},{id:"330920",title:"Dr.",name:"Glen",surname:"Cheng",slug:"glen-cheng",fullName:"Glen Cheng"},{id:"330967",title:"Mr.",name:"Nischal",surname:"Chennuru",slug:"nischal-chennuru",fullName:"Nischal Chennuru"}],corrections:null},{id:"79308",title:"Particulate Matter and Human Health",doi:"10.5772/intechopen.100550",slug:"particulate-matter-and-human-health",totalDownloads:179,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This chapter provides an introduction to particulate matter by discussing various ways of categorisation, characterisation and their health effects. The natural and anthropogenic sources of atmospheric particulate matter are discussed. The chapter also introduces qualitatively some aerosol concepts, such as their chemical composition and size distribution. Some examples are provided to illustrate how particulate matter, despite being microscopic particles, can manifest themselves in the atmosphere. Finally, the various pathways by which particulate matter impacts the health system are reviewed along with their interactions to understand concept behind the PM-associated health effects.",signatures:"Karuna Singh and Dhananjay Tripathi",downloadPdfUrl:"/chapter/pdf-download/79308",previewPdfUrl:"/chapter/pdf-preview/79308",authors:[{id:"343627",title:"Mr.",name:"Dhananjay",surname:"Tripathi",slug:"dhananjay-tripathi",fullName:"Dhananjay Tripathi"},{id:"415960",title:"Ms.",name:"Karuna",surname:"Singh",slug:"karuna-singh",fullName:"Karuna Singh"}],corrections:null},{id:"76043",title:"Heavy Metals in the Environment and Health Impact",doi:"10.5772/intechopen.97204",slug:"heavy-metals-in-the-environment-and-health-impact",totalDownloads:274,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Heavy metals are among the most harmful contaminants in the ecosystems due to their persistency, bioaccumulation and high toxicity. In this chapter, we presented the sources, distribution and pathways of heavy metals in soil, water and air. The physico-chemical properties, uses, toxicity and health hazards of the purely toxic heavy metals lead, cadmium and mercury were also described. Other essential heavy metals were briefly presented and the main health effects due to their deficiency or excess were displayed in this chapter. Finally, the various methods used for the removal of heavy metals from soil and aquatic environments were discussed with a focus on nanomaterials.",signatures:"Myriam El Ati-Hellal and Fayçal Hellal",downloadPdfUrl:"/chapter/pdf-download/76043",previewPdfUrl:"/chapter/pdf-preview/76043",authors:[{id:"346175",title:"Associate Prof.",name:"Myriam",surname:"El Ati-Hellal",slug:"myriam-el-ati-hellal",fullName:"Myriam El Ati-Hellal"},{id:"346535",title:"Prof.",name:"Fayçal",surname:"Hellal",slug:"faycal-hellal",fullName:"Fayçal Hellal"}],corrections:null},{id:"76363",title:"The Challenge of Water in the Sanitary Conditions of the Populations Living in the Slums of Port-au-Prince: The Case of Canaan",doi:"10.5772/intechopen.96321",slug:"the-challenge-of-water-in-the-sanitary-conditions-of-the-populations-living-in-the-slums-of-port-au-",totalDownloads:215,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Haitian cities are more and more prone to demographic growth, which has a lasting effect on water distribution infrastructures, as well as those that make it possible to clean it up. They are in touch with the growing demand for water, but also with the management methods of this resource. Over the past 25 years, the enlarged agglomeration of Port-au-Prince, the largest agglomeration in the country, has experienced very strong urban expansion with the creation of new precarious spaces. The literature reports that Haiti is now more than 64% urban and 35% of its population lives in the metropolitan area of Port-au-Prince, in the West Department. Over the past decade, the footprint of the Port-au-Prince metropolitan area has grown by 35%. Recent observations on the formation and development of some slums highlight the country’s vulnerability to land-based hazards, which support this form of urbanization through the emergence of environmental displaced persons. Canaan, a human settlement created following the earthquake of January 12, 2010 by presidential decree, and inhabited by the victims of this event, has a deficit in infrastructure and basic urban services. The results of our previous work on this territory lead to a much more in-depth reflection on the need to develop an index of vulnerability to environmental diseases for the population. In fact, most of the households that live there face very precarious situations. The health conditions associated with this context expose the population to increased risks of disease. The measures taken by families to treat water at home do not seem to limit their vulnerability to environmental diseases (infectious and chronic). Improving living conditions in Canaan with a view to sustainability therefore underlies major challenges. What avenues of intervention should be favored to facilitate a favorable development of the population, while taking into account the strong constraints that weigh on their daily lives? The objective of this study is precisely to analyze the vulnerability of the population to water-borne diseases.",signatures:"Yolette Jérôme, Magline Alexis, David Telcy, Pascal Saffache and Evens Emmanuel",downloadPdfUrl:"/chapter/pdf-download/76363",previewPdfUrl:"/chapter/pdf-preview/76363",authors:[{id:"293512",title:"Dr.",name:"Evens",surname:"Emmanuel",slug:"evens-emmanuel",fullName:"Evens Emmanuel"},{id:"334333",title:"Ms.",name:"Yolette",surname:"Jérôme",slug:"yolette-jerome",fullName:"Yolette Jérôme"},{id:"334334",title:"Ms.",name:"Magline",surname:"Alexis",slug:"magline-alexis",fullName:"Magline Alexis"},{id:"334337",title:"Prof.",name:"Pascal",surname:"Saffache",slug:"pascal-saffache",fullName:"Pascal Saffache"},{id:"350682",title:"MSc.",name:"David",surname:"Telcy",slug:"david-telcy",fullName:"David Telcy"}],corrections:null},{id:"79250",title:"Impact of Arsenic on Reproductive Health",doi:"10.5772/intechopen.101141",slug:"impact-of-arsenic-on-reproductive-health",totalDownloads:177,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Arsenic is ubiquitously present in the earth’s crust. Population across the world gets exposed to arsenic mainly through drinking water, responsible for causing diseases like hypertension, skin pigmentation, skin lesion, cardiovascular diseases, and even cancer. However, arsenic also disturbs the male and female hormone balance in the body, thus, interfering with the process of spermatogenesis and oogenesis. This eventually leads to infertility in the reproductive system irrespective of gender. Cohort studies have revealed that when pregnant women get exposed to arsenic-contaminated water; it leads to abortion, preterm birth, and stillbirth. Thus, arsenic contamination from any source has a devastating effect on the life of organisms and also on the environment.",signatures:"Sweety Nath Barbhuiya, Dharmeswar Barhoi and Sarbani Giri",downloadPdfUrl:"/chapter/pdf-download/79250",previewPdfUrl:"/chapter/pdf-preview/79250",authors:[{id:"346153",title:"Mr.",name:"Dharmeswar",surname:"Barhoi",slug:"dharmeswar-barhoi",fullName:"Dharmeswar Barhoi"},{id:"346159",title:"Ms.",name:"Sweety",surname:"Nath Barbhuiya",slug:"sweety-nath-barbhuiya",fullName:"Sweety Nath Barbhuiya"},{id:"436419",title:"Prof.",name:"Sarbani",surname:"Giri",slug:"sarbani-giri",fullName:"Sarbani Giri"}],corrections:null},{id:"76021",title:"Fluoride Content in Drinking Water and the Health Implications of Fluoride-Rich Water Consumption: An Overview of the Situation in Canada and Nigeria",doi:"10.5772/intechopen.97209",slug:"fluoride-content-in-drinking-water-and-the-health-implications-of-fluoride-rich-water-consumption-an",totalDownloads:199,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Fluoride is an inorganic monatomic anion of fluorine and forms part of essential reagents used by the chemical industry. It occurs naturally in several minerals and in trace quantities in water. Fluoride has been used to prevent tooth decay and in the treatment of osteoporosis. Extensive research has consistently demonstrated the safety and effectiveness of fluorides in the prevention of dental caries following the practice of water fluoridation. Despite these benefits, fluorides pose danger as an endocrine disruptor thus, affecting bones, brain, thyroid gland, pineal gland and blood sugar levels. In Canada, water fluoridation remains a contentious issue although dental decay constitutes the most common chronic disease. However, several Canadians are receiving the benefits of water fluoridation and about 1% have access to naturally fluoridated water. In Nigeria, the prevalence of dental caries has been documented to be greatly reduced following fluoridation of public water supplies in areas where the condition was endemic. Fluoride is therefore the only medicine added to public water, and at the recommended level, fluoride is safe and effective in the reduction of dental decay and poses no risk for health problems. Hence, this article highlighted fluoride content in drinking water and the health implications of consuming fluoride-rich water with a focus on the situation in Canada and Nigeria.",signatures:"Ochuko Orakpoghenor, Talatu Patience Markus, Meshack Inotu Osagie and Paul Terkende Hambesha",downloadPdfUrl:"/chapter/pdf-download/76021",previewPdfUrl:"/chapter/pdf-preview/76021",authors:[{id:"297491",title:"Ph.D. Student",name:"Ochuko",surname:"Orakpoghenor",slug:"ochuko-orakpoghenor",fullName:"Ochuko Orakpoghenor"},{id:"347776",title:"Dr.",name:"Talatu",surname:"Patience Markus",slug:"talatu-patience-markus",fullName:"Talatu Patience Markus"},{id:"347777",title:"Mr.",name:"Meshack",surname:"Inotu Osagie",slug:"meshack-inotu-osagie",fullName:"Meshack Inotu Osagie"},{id:"347778",title:"Dr.",name:"Paul",surname:"Terkende Hambesha",slug:"paul-terkende-hambesha",fullName:"Paul Terkende Hambesha"}],corrections:null},{id:"75463",title:"Sustainable Use of Biochar in Environmental Management",doi:"10.5772/intechopen.96510",slug:"sustainable-use-of-biochar-in-environmental-management",totalDownloads:292,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Conversion of agricultural wastes into eco-friendly and low cost biochar is not only a smart recycling strategy but a panacea to environmental pollution management. Agricultural wastes biochar can be an effective alternative technique for controlling contaminants due to its low cost, high-efficiency, simple to use, ecological sustainability and reliability in terms of public safety. Biochars have made substantial breakthroughs in reducing greenhouse gases emissions, reducing soil nutrient leaching, sequester atmospheric carbon into the soil, increasing agricultural productivity, and reducing bioavailability of environmental contaminants. Recent advances in the understanding of biochars warrant a proper scientific evaluation of the relationship between its properties and impact on soil properties, environmental pollutant remediation, plant growth, yield, and resistance to biotic and abiotic stresses. The main factors controlling biochar properties include the nature of feedstock, heat transfer rate, residence time and pyrolysis temperature. Biochar efficacy in pollutants management largely depends on its elemental composition, ion-exchange capacity, pore size distribution and surface area, which vary with the nature of feedstock, preparation conditions and procedures. The chapter explored the possibility of using biochar from agricultural wastes as a suitable alternative for the remediation of environmental pollutants, soil conditioning and the long-term biochar application in the environment.",signatures:"Ammal Abukari, Ziblim Abukari Imoro, Abubakari Zarouk Imoro and Abudu Ballu Duwiejuah",downloadPdfUrl:"/chapter/pdf-download/75463",previewPdfUrl:"/chapter/pdf-preview/75463",authors:[{id:"342495",title:"Mr.",name:"Abudu Ballu",surname:"Duwiejuah",slug:"abudu-ballu-duwiejuah",fullName:"Abudu Ballu Duwiejuah"},{id:"342497",title:"Mr.",name:"Ammal",surname:"Abukari",slug:"ammal-abukari",fullName:"Ammal Abukari"},{id:"342501",title:"Dr.",name:"Ziblim Abukari",surname:"Imoro",slug:"ziblim-abukari-imoro",fullName:"Ziblim Abukari Imoro"},{id:"419594",title:"Dr.",name:"Abubakari",surname:"Zarouk Imoro",slug:"abubakari-zarouk-imoro",fullName:"Abubakari Zarouk Imoro"}],corrections:null},{id:"74632",title:"Reproductive Toxicity of Arsenic: What We Know and What We Need to Know?",doi:"10.5772/intechopen.95379",slug:"reproductive-toxicity-of-arsenic-what-we-know-and-what-we-need-to-know-",totalDownloads:322,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the most recent the environmental provident and threatening conduct of arsenic has increased the consideration of the world due to its pollution and hazardous effects throughout the world. Arsenic contamination is serious issue throughout the world and is substantial risk factor in most of countries including China, U.S.A, India, Bangladesh, Mexico and Argentina. Several experimental models have been established to understand the diseases caused by arsenic exposure. However reproductive and developmental toxicity have been poorly understood. The objectives of this study are to discuss current landscapes and future horizons of arsenic toxicity in human and animals in relation to various toxicity routes including oral route involving food and water or through inhalation of agricultural pesticides. Addition of current evidence on the development of destiny and actions of arsenic toxicity in human and animal population and other species will lessen the uncertainties in the hazard assessment for arsenic. This effort would help to protect the public health against the toxic and carcinogenic effects associated with arsenic exposure.",signatures:"Hafiz Ishfaq Ahmad, Muhammad Bilal Bin Majeed, Abdul Jabbar, Ruqia Arif and Gulnaz Afzal",downloadPdfUrl:"/chapter/pdf-download/74632",previewPdfUrl:"/chapter/pdf-preview/74632",authors:[{id:"342163",title:"Dr.",name:"Hafiz Ishfaq",surname:"Ahmad",slug:"hafiz-ishfaq-ahmad",fullName:"Hafiz Ishfaq Ahmad"},{id:"342165",title:"Dr.",name:"Muhammad Bilal Bin",surname:"Majeed",slug:"muhammad-bilal-bin-majeed",fullName:"Muhammad Bilal Bin Majeed"},{id:"342166",title:"Dr.",name:"Abdul",surname:"Jabbar",slug:"abdul-jabbar",fullName:"Abdul Jabbar"},{id:"342167",title:"Ms.",name:"Ruqia",surname:"Arif",slug:"ruqia-arif",fullName:"Ruqia Arif"}],corrections:null},{id:"76752",title:"Chemical Pollution of Drinking Water in Haiti: An Important Threat to Public Health",doi:"10.5772/intechopen.97766",slug:"chemical-pollution-of-drinking-water-in-haiti-an-important-threat-to-public-health",totalDownloads:214,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The geophysical environment of the Republic of Haiti is characterized by hydrological and biogeographical climatic phenomena, and a relief marked by its rugged appearance. Most of the territory is occupied by mountains formed of limestone. The differences in level are very marked. Fragmentation is another feature of the relief. These environmental imperfections juxtaposed with difficult socioeconomic conditions and anthropogenic actions raise questions about possible chemical metal pollution of the country’s water resources. Indeed, the predominance of limestone in the Haitian geology generate water hardness, and in the case where the magnesium concentration is less than 7 mg/l, this water may be the source of cardiovascular diseases. Studies carried out on several water points show a total hardness greater than 200 mg/l. In Port-au-Prince, concentrations of lead ranging from 40 μg/L to 90 μg/L and high Cr (III) risks were measured and estimated in groundwater and drinking water. Concentration of fluorine ranging from 0 to 2 mg/l were obtained from water resources. Concentration above 1.5 mg/l have been found from alluvial aquifers. Chronic public health risks, such as cardiovascular diseases, deterioration of the psychological development of children, irreversible functional and morphological renal changes, and dental fluorosis, strain Haiti’s water resources. Chemicals’ exposures seem to pose a threat to public health in Haiti, which need to be studied. The aim of this study is: (i) to analyze the contribution of geology and anthropogenic actions in the alteration of water quality, (ii) to review the toxicology of chemicals detected in water distributed in Port-au-Prince.",signatures:"Alexandra Emmanuel and Evens Emmanuel",downloadPdfUrl:"/chapter/pdf-download/76752",previewPdfUrl:"/chapter/pdf-preview/76752",authors:[{id:"293512",title:"Dr.",name:"Evens",surname:"Emmanuel",slug:"evens-emmanuel",fullName:"Evens Emmanuel"},{id:"334364",title:"Ph.D.",name:"Alexandra",surname:"Emmanuel",slug:"alexandra-emmanuel",fullName:"Alexandra Emmanuel"}],corrections:null},{id:"77660",title:"Microplastics and Environmental Health: Assessing Environmental Hazards in Haiti",doi:"10.5772/intechopen.98371",slug:"microplastics-and-environmental-health-assessing-environmental-hazards-in-haiti",totalDownloads:245,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Microplastics (MP) refer to all plastic particles that are less than 5 mm in size. Over the past decades, several studies have highlighted the impact of microplastics (MP) on living organisms. In addition to being pollutants themselves, these synthetic polymers also act as vectors for the transport of various types of chemicals in natural ecosystems. MP has been ubiquitously detected in a wide range of shapes, polymers, sizes and concentrations in marine water, freshwater, agroecosystems, atmospheric, food and water environments. Drinking water, biota, and other remote places. According to the World Bank, over 80% of the world’s marine litter is plastic and the concentration of litter on Caribbean beaches is often high, with a high presence of single-use plastics and food containers. In its work, the World Health Organization (WHO) suggests an in-depth assessment of microplastics present in the environment and their potential consequences on human health, following the publication of an analysis of the state of research on microplastics in drinking water. It also calls for reducing plastic pollution to protect the environment and reduce human exposure. In Haiti, the bay of Port-au-Prince is the natural receptacle of all the urban effluents generated by human activities in the Metropolitan Zone. This urban wastewater carries household waste, sludge from pit latrines and sewage, industrial wastewater which largely contributes to the pollution of the bay. Furthermore, 1,673,750 tonnes per year of household waste, including 93,730 tonnes of plastic waste, are not collected. What are the environmental dangers represented by the MP contained in those wastes for living organisms in exposed tropical ecosystems? The purpose of this paper is: (i) to do a bibliographical review of the physical and chemical properties, as well as the toxicological profile of MP, (ii) to identify the environmental hazards associated with MP contained in urban waste in the metropolitan area of Port-au-Prince.",signatures:"Daphenide St. Louis, Ammcise Apply, Daphnée Michel and Evens Emmanuel",downloadPdfUrl:"/chapter/pdf-download/77660",previewPdfUrl:"/chapter/pdf-preview/77660",authors:[{id:"293512",title:"Dr.",name:"Evens",surname:"Emmanuel",slug:"evens-emmanuel",fullName:"Evens Emmanuel"},{id:"334360",title:"Ms.",name:"Daphnée",surname:"Michel",slug:"daphnee-michel",fullName:"Daphnée Michel"},{id:"334362",title:"Ms.",name:"Daphenide",surname:"St.Louis",slug:"daphenide-st.louis",fullName:"Daphenide St.Louis"},{id:"414780",title:"MSc.",name:"Ammcise",surname:"Apply",slug:"ammcise-apply",fullName:"Ammcise Apply"}],corrections:null},{id:"77007",title:"A Review of Alternative Marine Fuels",doi:"10.5772/intechopen.97871",slug:"a-review-of-alternative-marine-fuels",totalDownloads:202,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Today, ships navigating all around the world are not allowed to emit SOx more than 0.5%. Same regulation for nitrogen has already come into force. More and more nations are becoming aware and concerned about the negative effects of climate change, whereas many countries are already feeling the effects of harmful greenhouse gas emissions. Therefore, the world’s fleet needs a new fuel types, which are alternative to conventional petroleum-based ship fuels. Benefits such as low sulphur standards accompany all alternative fuel options. As will be discussed further in Section 2, there are challenges and limitations associated with CO2 emissions along with benefits. The review of the literature and field shows that the impact of these current choices on the management and environments is still not bright enough, although each alternative has consisted entirely different effects in their body and each alternative pose specific risks to the environment, crew, management and port states. This chapter gives a review on the impact of each alternative fuels on the environment. In addition, the chapter touches upon handling of risks associated with alternative fuels and technologies.",signatures:"Şevket Süleyman İrtem",downloadPdfUrl:"/chapter/pdf-download/77007",previewPdfUrl:"/chapter/pdf-preview/77007",authors:[{id:"347375",title:"Ph.D. Student",name:"Şevket Süleyman",surname:"İrtem",slug:"sevket-suleyman-irtem",fullName:"Şevket Süleyman İrtem"}],corrections:null},{id:"76323",title:"Vector-Borne Diseases and Climate Change in the Environmental Context in Haiti",doi:"10.5772/intechopen.96037",slug:"vector-borne-diseases-and-climate-change-in-the-environmental-context-in-haiti",totalDownloads:310,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Climate change is one of the main challenges facing many countries, particularly developing countries, because of its negative impact on their various ecosystems and their socio-economic development, which very often leads them down a slow descent into poverty. This is because climate change can manifest itself in different forms such as climate variability and extreme events (droughts, epidemics, floods, storms and hurricanes), which can affect biodiversity and cause many human and animal diseases and deaths. In fact, the evolution of ecosystems is dependent on climate and environmental change and appears to be closely associated with many emerging or re-emerging diseases. In general, the ecosystems considered to be most exposed to climate change are those located in and around the intertropical convergence zone in particular. They are believed to be closely linked to the occurrence of several emerging diseases, particularly vector-borne diseases. For years, the Republic of Haiti has been experiencing the adverse effects of these global changes with a marked disruption of its rainfall pattern and prolonged periods of drought as well as a pronounced increase in temperatures even in high altitude areas. Although there is evidence that climate change is increasing the frequency of vector-borne diseases and may contribute to increasing the virulence of their pathogens, there are very few studies conducted in Haiti on the relationship between climate change and vector-borne diseases. The purpose of this chapter is to define the interrelationships between climate change and vector-borne diseases in Haiti by identifying avenues of research to better understand the effects of climate change on public health and to make appropriate recommendations to decision-makers to ensure proper management.",signatures:"Ketty Balthazard-Accou, Max François Millien, Daphnée Michel, Gaston Jean, David Telcy and Evens Emmanuel",downloadPdfUrl:"/chapter/pdf-download/76323",previewPdfUrl:"/chapter/pdf-preview/76323",authors:[{id:"293512",title:"Dr.",name:"Evens",surname:"Emmanuel",slug:"evens-emmanuel",fullName:"Evens Emmanuel"},{id:"334360",title:"Ms.",name:"Daphnée",surname:"Michel",slug:"daphnee-michel",fullName:"Daphnée Michel"},{id:"292961",title:"Dr.",name:"Ketty",surname:"Balthazard-Accou",slug:"ketty-balthazard-accou",fullName:"Ketty Balthazard-Accou"},{id:"334357",title:"Dr.",name:"Max François",surname:"Millien",slug:"max-francois-millien",fullName:"Max François Millien"},{id:"334363",title:"Dr.",name:"Gaston",surname:"Jean",slug:"gaston-jean",fullName:"Gaston Jean"},{id:"354599",title:"MSc.",name:"David",surname:"Telcy",slug:"david-telcy",fullName:"David Telcy"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"9102",title:"Asbestos-related Diseases",subtitle:null,isOpenForSubmission:!1,hash:"05268073ee2a653571449e4519749085",slug:"asbestos-related-diseases",bookSignature:"Takemi Otsuki",coverURL:"https://cdn.intechopen.com/books/images_new/9102.jpg",editedByType:"Edited by",editors:[{id:"34101",title:"Prof.",name:"Takemi",surname:"Otsuki",slug:"takemi-otsuki",fullName:"Takemi Otsuki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6728",title:"Trace Elements",subtitle:"Human Health and Environment",isOpenForSubmission:!1,hash:"4e1144832b71a4ffcabc7cc31ce911b2",slug:"trace-elements-human-health-and-environment",bookSignature:"Hosam El-Din M. 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\r\n\tStroke is the third leading cause of mortality and morbidity across the globe. Intracerebral hemorrhage is second most common subtype of stroke which, if managed properly and in time, can save many lives. This book ambitiously undertakes review of contemporary as well as advanced understanding of the subject. Better investigative armamentarium, newer therapies, rehabilitation procedure and stroke care units have revolutionized the management of this condition with a favorable outlook.
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Subsequently, he received his MD diploma (Medicine) from the University of Rajasthan in 1974, and DM (Neurology) from the Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh in 1985. He served in the Armed Forces India as a Physician and Neurologist for 24 years and retired as Lt Col in 1998. From 1994 to 1998, he also served as an Associate Professor, Armed Forces Medical College, Pune. He was awarded Chief of Army Staff’s Commendation in 1980. Since 1998, he has been pursuing clinical practice in neurology at various hospitals at Jodhpur and at Guwahati Assam. He has been a Visiting Professor, Ph.D. guide, and advisor to Jain Visva Bharti University (JVBI) and Bhagwan Mahaveer International Research Centre (BMIRC), Ladnun, Rajasthan since 2009. He is a Director of Research at the Spiritual Training Research Foundation (STRF), Mumbai, India. 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Intentionality is one of the more complex elements in the concept of violence, however, the World Health Organization (WHO) explains that any act causing implications for an individual’s health is considered a violent act, even when sustained by the culture or when there was an intention to use force without the intention to cause harm [1].
As far as the typology is concerned, violence is divided into three types: self-inflicted, interpersonal, and collective. Self-inflicted violence is subdivided into suicidal behavior and self-abuse; collective violence, into social, political, and economic; lastly, interpersonal, divided into two subcategories: violence within the family or by a close partner, which mostly occurs between family members, and community violence, which takes place among people who are unrelated [2].
With regard to the nature of violent acts, these may be classified as physical, sexual, psychological, deprivation or abandonment. The four types of violent act occur in each of the main categories and subcategories, except for self-inflicted violence. Violence towards children, committed inside the home, for example, may include physical, sexual, or psychological abuse, as well as negligence or abandonment [3].
Specifically, with regard to children and adolescents, violent acts (physical, sexual, psychological, negligent) are called maltreatment and refer to various forms of violence, in the majority of cases with events being repeated and committed by someone close or the guardian of the child or adolescent [4].
Studies into violence, conducted by Finkelhor et al. [5], assert that living with or experiencing situations of violence, with the particular potential to cause trauma, is called victimization. Studies into victimization describe five types of violence: victimization through conventional crime, victimization through maltreatment, victimization by peers, sexual victimization and indirect, witnessed victimization.
Victimization through conventional crime is commonly identified by the police authorities as, for example, assault, theft, vandalism, and prejudice. As for violence through maltreatment, this is detected through living with situations of violence directly related to the family or to guardians. This type of victimization also includes negligence, physical and psychological abuse, in the form of depriving children and/or adolescents of basic necessities like food and hygiene. Victimization by peers is characterized by the aggression that occurs by individuals within the same age group, normally among students. In this respect, aggression through the practice of bullying is also taken into account as well as attacks by groups and physical and psychological violence. Sexual victimization relates to aggression related to issues of sexuality. For Finkelhor et al. [5], sexual victimization is more than just penetration, it also includes lewd acts without the consent of the individual or even with consent where the children are not old enough to be responsible for their choices; this also encompasses sexual aggression by an adult, by peers, sexual harassment, rape or attempted rape and sexually-related verbal harassment. Lastly, indirect victimization refers to the witnessing of violence suffered by others, and this also covers issues such as witnessing domestic violence, seeing parents attack siblings or their spouses, witnessing attacks, robberies, homicides, shootings, terrorism, and exposure to ethnic conflict.
In epidemiological terms, studies show that approximately 40 million children in the world, under the age of 15, have suffered abuse and negligence [1] and, in the USA, between 25% and 66% of children and adolescents are exposed to traumatic events during childhood [6, 7]. As far as Brazil is concerned, a survey by the Brazilian Center for Latin American Studies, based on the Ministry of Health’s Mortality Information System (SIM), shows that the number of homicides of teenagers, between 1980 and 2010, rose 346%.
Brazilian researcher that investigates violence directed against children and adolescents point to alarming data. According to the National Human Rights Ombudsman, 58.9% of the complaints received via channels such as Dial 100 refer to some type of violence against children and adolescents. The main types of violence reported are mistreatment: negligence (61,416), psychological violence (39,561), and physical violence (33,105). In 2017 alone, there were 84,049 reports of physical violence and, in the previous year, there were 76,171. In this sense, the data indicate that 68% of Brazilian children and adolescents aged up to 14 years, which is equivalent to 30.3 million children and adolescents, have already suffered corporal violence at home [8].
An exploratory/descriptive desk study conducted by Júnior et al. [9], analyzed the characterization of cases of domestic violence against children and adolescents in the Brazilian city of Volta Redonda, situated in the state of Rio de Janeiro. The investigation was carried out based on an analysis of the patient records of registered children and adolescents cared for as victims of maltreatment by parents, relatives, and/or guardians in the city’s Specialized Social Welfare Reference Center (CREAS). The results indicated that, of the 210 patient records analyzed, 29% were victims of physical violence, 29% sexual violence, 29% were linked to negligence and 13% were cases of psychological violence. Although this study cannot be generalized as it makes use of a convenience sample, some important points were deliberated. The prevalence of the identification of physical violence, as it leaves marks on the body, and sexual violence, as it causes significant harm to the victims’ health, is capable of mobilizing more the child protection institutions and society in general, which probably explains the higher volumes of identification. As for negligence, though difficult to identify, as it involves the economic and social aspects of each family or social group, detection is possible when there is already contact between the social institutions and the families in situations of risk and vulnerability. On the other hand, psychological violence, which accounted for the smallest percentage of identification, requires children’s welfare professionals to redouble their attention because the indicators of its manifestation are not so straightforward, however, the consequences are equally serious for the victims’ mental health.
One study conducted by Lin et al. [10] investigate the link between serious child abuse and cerebral activation based on Magnetic Resonance Imaging examinations during a sustained attentional task. A total of 70 individuals (13 to 20 years old) took part, divided into three groups: history of abuse before 12 years old; psychiatric control group (no maltreatment but with psychiatric disorders); control group (no maltreatment, no psychological disorders). The results indicated that the participants exposed to child abuse exhibited results that show that the longer the youngster suffered abuse, the worse the performance in capacity to maintain sustained attention.
Another important piece of data indicates that, according to the Ministry of Women, Family and Human Rights (MMFDH), of the accusations received via Helpline 100 in 2018, over 17,000 were related to sexual abuse and sexual exploitation involving children and adolescents. Thus, based on the data presented and seeking protective measures for children and adolescents, in Brazil, the Child and Adolescent Statute (ECA) is regarded as one of the most advanced pieces of legislation in the world in terms of child protection [11]. Among the general clauses, the law establishes full protection for children and adolescents, considering that children, for the purposes of the law, are those aged under 12 while adolescents are those aged between 12 and 18 years. In terms of protection against violence, article 5 of the ECA states that no child or adolescent shall be the object of any form of negligence, discrimination, exploitation, violence, cruelty, or oppression and that any attempt, through commission or omission, against their fundamental rights must be punished in accordance with the law. Despite the ECA and the penalties it imposes on people who commit violence against children and adolescents, the percentage of victims within this age group is still significant.
Despite the ECA being a statute that provides for severe infractions for those who are aggressors, the number of victimizations is still significant. The aim of the ECA, therefore, is the full protection of children and adolescents, seeking to guarantee their cognitive, psychosocial, and physical development. The dividing line between child and adolescent is important, mainly as it considers that significant, important differences exist during each period of their lives [12].
Development in childhood is characterized by constant processes of development in terms of cognitive function and social skills. In the third stage of childhood, between six and 11 years of age, cognitive development is seen as an increase in cognitive skills that permits an improvement in the ability to learn as well as preparation for academic performance. In terms of psychosocial development, relationships between peers, schoolmates, and others take on fundamental importance. In adolescence, interest in peer relationships remains strong, however, with a greater concern to belong to a group, which may exert positive or negative influences. Cognitive development is characterized by the ability to think in abstract terms, but immature thinking persists in some attitudes and conduct, with more impulsive behavior [12]. Situations of violence may adversely affect this important period of development, causing impairment of cognitive, social, emotional skills and, consequently, may compromise the quality of life of victimized subjects.
With regard to the damage to quality of life, for victimized children, a study by Matos, Pinto, and Stelko-Pereira [13], which aimed to investigate the existence of a possible connection between exposure to sexual abuse in childhood and inferior quality of life in university students, noted that childhood sexual abuse is negatively associated with quality of life in adults. The results of another study, conducted by Dias [14], although investigating a different age group, specifically relating to the impact of violence on the quality of life of adult females, showed that violence exerts a negative impact on the quality of life of victims and also generates physical trauma, posttraumatic stress disorder, stress, and depression.
Studies into the relationship of experience of violence in childhood and adolescence have increased as a result of the recognition of the dimensions of the phenomenon as a serious public health problem, on account of the high index and the consequences they have for the physical, psychological and cognitive health of people who suffer violence [15]. In order to identify victimization, for the most part, studies look to institutions that protect victimized children, as well as instruments (questionnaires and/or scales) that can be answered by the parents/guardians or by the child or adolescent him/herself. The instruments most frequently employed are the Child Maltreatment Questionnaire, Child Trauma Questionnaire, and Juvenile Victimization Questionnaire [4, 10, 16, 17]. The last two instruments in this list include validity studies in the national context conducted by Grassi-Oliveira et al. [18] and Faria and Zanini [19], respectively, and are not instruments restricted to the use of psychologists.
Despite the variety in the way victimization is identified, studies have shown impairment to cognitive functions in this age group [4, 10, 20]. However, there are still very few studies available that have sought to investigate the impact of violence specifically on executive functions.
Executive function (EF) refers to the processes called upon whenever it is necessary to focus attention, manage and control behavior or action towards a goal, evaluate the efficiency of this behavior, and readjust strategy when required. Thus it is possible to assert that the human capacity to adapt to different situations is heavily associated with good executive function [21, 22, 23, 24].
In spite of the agreement between the theoretical models that EF is important for good brain function, insofar as it relates to its definition and component structure, there seems to be a divergence in ideas [14, 25, 26, 27]. Thus, several different EF models have been developed and studied.
One of the more influential theories about EF proposes the association between the frontal lobes, their principal connections, and the Supervisory Attentional System (SAS). SAS is a model developed by Norman and Shallice [28] and describes EF as a specific system in the processing of information, which takes place based on two processes. An automatic process is the ability to automatically select responses based on information in an existing repertoire. The controlled process is identified as the modification or even the construction of new responses, including decision-making, mental flexibility, inhibitory control, and planning [28, 29]. In this regard, there are some studies about the relationship of violence with EF [10, 30] which used attention as a component of EF.
One widely accepted model is that of Miyaki et al. [31], for whom EF is composed of three basic components or nuclear EFs, namely: working memory (WM), cognitive flexibility (CF), and inhibitory control (IC). Subsequently, Diamond [21] carried out a new study corroborating the idea that three nuclear EFs exist, but that they are the basis for the development of more complex components such as planning, deductive reasoning, and problem resolution, subsequently designated complex executive functions. For a better understanding of the model, it is necessary to define each of these components.
IC involves the ability to control the behaviors of attention, thoughts, and emotions, inhibiting an automatic behavior or a distraction and, instead of generating said behavior, do what is most appropriate or necessary [22]. WM is defined as the ability to keep information in one’s mind and deal with it over a short period of time, enabling understanding, learning, and reasoning, as well as problem resolution [32]. CF involves the capacity to change perspectives, alternate attentional focus, favoring the ability to adapt to the environment, enabling the individual to evaluate his/her performance in a particular situation, seeking to comply with rules, and problem resolution [22, 33]. With regard to complex EFs, planning involves the ability, based around an initial starting point, to set an objective, define the best ways to achieve it, organize the necessary steps to this end, analyze the efficacy and, if necessary, adjust the execution [22]. Problem resolution involves the ability to create and test solutions for conflicts, through mental representation, in the planning and implementation of strategies and monitoring [34].
Another skill developed from the three nuclear components is decision-making, crucial for day-to-day functioning because it involves a process of choice of one among many alternatives in situations that include uncertainty, generally guided by an emotional or motivational component. During decision-making, other EF components are involved like operational memory, cognitive flexibility, inhibitory control, and planning [23, 34].
Regarding the development of EF in the early years of life, it is considered a unitary construct, that is to say, in this phase it is not possible to distinguish between each component, however, it is already possible to identify an improvement in the performance of the components in the first year of life [35].
From school age, the development of operational memory and cognitive flexibility is relatively linear; in this period, the EF components appear in sequence: firstly working memory, then inhibitory control. The two components in combination permit the development of cognitive flexibility [23, 36].
Adolescence is characterized by an increase in impulsiveness and, consequently, by a pattern of immediatist choices, changes in the course of action without making a conscience judgment, unintended behaviors, and a tendency to act without planning. All these aspects lead to risk-taking behavior without evaluating the consequences, suggesting a lesser capacity for self-regulation and inhibitory control [23].
WM is an essential ability in learning, both in childhood and in adolescence and, although there are a series of abilities required for learning, there is evidence that working memory is one of the best predictors of performance at school [37, 38]. In this regard, it is important to stress that the development of EF is directly related to the ability of children and adolescents in the learning processes, as well as the ability to adapt to new situations.
As EF is important for the learning processes, the evaluation of this function must investigate, in minute detail, if each of the components is developing as expected. There are specific batteries for its evaluation, such as the Behavioral Assessment of the Dysexecutive Syndrome (BADS) and the Delis Kaplan Executive Function System (D-KEFS). These batteries perform an overall evaluation of EF and serve a population ranging in age from eight to 87 years.
There are several favorable psychological tests, which evaluate EF, as well as instruments validated for use. The Wisconsin Card Test, for example, is used to evaluate EF, specifically cognitive flexibility, as well as Trail Making Test and the Five Digit Test (FDT). To evaluate WM, the WISC-IV subtests are used, such as digit span and numbers and letters sequencing and, to evaluate inhibitory control, FDT, Stroop Test, and the Hayling Test are used. On the one hand, the wide variety of tests to evaluate EF permits a full investigation based on the collection of data from all the components, however, with regard to the comparison of data in studies, it may make analysis difficult as the studies use different instruments and tests.
Despite the diversity, in the way, the data is collected, either for identifying violence or evaluating EF, international studies point out the consequences of victimization for children and adolescents. Some studies have investigated the consequences of short- and long-term violence with victims who presented with a condition indicative of posttraumatic stress disorder, psychiatric disorders, or the use of illicit substances such as alcohol and drugs [39, 40, 41, 42, 43]. Other studies have shown that victimization as a result of maltreatment, as well as sexual victimization, may impair the development of EF in terms of the components of working memory, cognitive flexibility, and inhibitory control [39, 41, 44, 45].
So, based on the data presented, the present study aimed to perform a literature review of the literature concerning studies that investigated the relationship between living with violence and the development of EF in children and adolescents, over the last 10 years. It also intends to demonstrate how these impairments can affect the quality of life of these children and adolescents.
Articles in scientific reviews, published within the last 10 years, which sought to assess the relationship between living with violence and executive function in children and adolescents aged between six and 16, located in the following databases: PsycINFO, Pubmed/Medline, BVS, Lilacs, Web of Science, Scopus and Gale.
In order to carry out this literature review, the following databases were used: PsycINFO, Pubmed/Medline, BVS, Lilacs, Web of Science, Scopus, and Gale, with articles, published up to October 2019. In these databases, the potentially relevant documents were selected using the following descriptors: executive functions, violence, child, children, adolescent, and adolescence, inserting the
Studies between 2009 and October 2019 were accepted, reviewed by peers, and published in the English, Spanish and Portuguese languages. Initially, 486 articles were located, of which 200 were repeated articles. After a reading of the titles and abstracts of the remaining 286 articles, 221 were excluded, in accordance with the following criteria: articles that were not available in their entirety (16), that had no connection with the proposed topic (172), comprising longitudinal studies (7), with a target demographic of subjects over 16 years of age (10), with a target demographic of subjects under 6 years of age (11), related to the use of illicit drugs (5). A total of 65 articles remained, selected for a full-text reading, to be subsequently included or excluded in accordance with the following criteria:
Inclusion criteria: (1) articles that investigated the relationship between violence and EF, (2) articles with a target demographic between six and 16 years of age, (3) studies with a control group. Exclusion criteria: duplicated articles (2), articles not available in full, (3) articles with a target demographic under 6 years of age, (4) articles that did not indicate the instruments used to evaluate EF. Based on the final analysis of the selection, the studies were characterized by author and year of publication, objective, age range of target demographic, type/nature of violence, instruments used, evaluated EF components and results. Figure 1 represents the detailed flowchart of the study selection process.
Flowchart of studies selected for review.
Figure 1 indicates that the initial search of the databases identified 486 files. After applying inclusion and exclusion criteria, 65 articles remained for full-text reading. After the reading, the following studies were excluded: outside the studied age range (n = 25), those that did not have a control group (n = 23), those without instruments to measure EF (n = 13), and those which were literature or systematic reviews (n = 4), leaving a total of eight articles.
There follow a series of tables with the results obtained in this review study. Table 1 describes the eight articles selected according to the inclusion criteria, identifying the authors, number of participants, age group, and study objectives.
De Bellis et al. [30] | Children (7 and 8 years old) | To investigate impairment in cognitive functions in neglected and sexually abused children. The children were divided into three groups: neglected and with symptoms of PTSD; neglected but no PTSD, children neither neglected nor PTSD (control group). The following cognitive domains were investigated: IQ, reading, math, fine-motor coordination, speech, visuospatial perception, memory, attention/ executive function. |
Nooner et al. [45] | 202 children (11 and 12 years old). | To investigate the impact of maltreatment on cognitive functions, comparing boy and girl victims. The cognitive functions investigated were: attention, speech, memory, intelligence, EF, and academic performance (reading, writing). The children were divided into 4 groups: boys with and without maltreatment; girls with and without maltreatment. |
Spann et al. [16] | 30 adolescents (12 to 17 years old). | To investigate the relationship between maltreatment and EF, specifically cognitive flexibility in adolescents without psychiatric disorders. The adolescents, divided into two groups: with and without a history of maltreatment. |
Borges and Dell’Aglio [39] | 26 children and adolescents (8 to 13 years old) | To identify the manifestation of symptoms of PTSD and impairment of attention, verbal memory, cognitive flexibility/executive function in girls that suffered sexual abuse. Divided into 2 groups: girls who were victims of sexual abuse and girls without a history of sexual abuse. |
Smith et al. [46] | 80 adolescents (11 to 18 years old) | To investigate if adolescents who suffered maltreatment exhibited worse performance in EF than the group which did not suffer maltreatment. Divided into 2 groups; with and without maltreatment. |
Tran et al. [17] | 1851 children and adolescents (12 to 17 years old) | Cross-sectional study investigating associations between different forms of maltreatment and emotional function, cognitive function, physical health, as well as the effects of the moderation of ethnicity and gender. Divided into 2 groups, with and without maltreatment. |
Lim et al. [10] | 70 adolescents (13 to 20 years old) | To investigate the link between serious child abuse and cerebral activation based on Magnetic Resonance Imaging examinations during a sustained attentional task. History of abuse before 12 years old; psychiatric control group (no maltreatment but with psychiatric disorders); control group (no maltreatment, no psychological disorders). |
Vasilevski and Tucker [47] | 82 children and adolescents (12 to 16 years of age) | To investigate to what extent maltreatment impacts cognitive performance, including the EF of adolescents who suffered maltreatment. Divided into two groups: the first composed of adolescents who suffered severe maltreatment and the second, adolescents who did not suffer any maltreatment. |
Authors, Participants, and Objective of the study.
The results displayed in Table 1 show that the number of participants ranged from 26 to 1851. As far as the age range is concerned, just one study analyzed only children [30], three investigated both children and adolescents [39, 45, 46] and four studies investigated adolescents [10, 16, 17, 47]. With regard to the objectives of the studies, it was possible to observe that all the articles included studies related to maltreatment. Two studies sought to identify a correlation between maltreatment, cognitive/executive functions, and Post Traumatic Stress Syndrome (PTSD) [30, 39], and one sought to identify the difference in the impact of maltreatment in adolescents with psychiatric disorders [10].
Table 2 shows that the most studied form of violence is interpersonal based on an investigation into maltreatment, however, several articles investigated specific types of maltreatment, namely negligence, physical abuse, sexual abuse, emotional abuse, and witnessed violence. Five articles investigated negligence ([30]; Nooner et al. [45]; [16, 17, 46]); four studies investigated physical abuse [16, 17, 45, 46]; four, sexual abuse [17, 39, 45, 46]; two, emotional abuse [45, 46]; two, domestic violence [45, 46]; and one article investigated maltreatment, without specifying the nature thereof [47].
De Bellis et al. [30] | Negligence (excludes sexual abuse). | |
Nooner et al. [45] | Maltreatment, negligence, physical abuse, sexual abuse, witnessing interpersonal violence at home, and emotional abuse. | |
Borges and Dell’Aglio [39] | Sexual abuse | Reference services for sexually abused children. |
Spann et al. [16] | Physical abuse, emotional abuse, and negligence. | |
Smith et al. [46] | Physical, sexual, or emotional abuse, negligence, and domestic violence. | Collection of records from teachers and tutors. |
Lim et al. [10] | Severe child abuse. | |
Tran et al. [17] | Physical abuse, sexual abuse, and negligence. | |
Vasilevski and Tucker [47] | Maltreatment |
Authors, types of violence, and instruments employed.
As for the way to identify violence, five studies recruited children or adolescents from institutions or agencies responsible for caring for victimized children and/or adolescents [30, 39, 45, 46, 47], two studies used the Child Trauma Questionnaire [10, 16] and one the Child Maltreatment Questionnaire [17]. Both instruments are self-report inventories composed of items to identify emotional, physical, or sexual abuse, and negligence in children and adolescents.
The results observed in Table 3 show that the components of EF evaluated in six of the eight studies agree to the Miyake et al. [31] model that considers cognitive flexibility, working memory, and inhibitory control as the basic components for the evaluation of EF, but only one study evaluated the three components in conjunction [46]. Two studies evaluated two components: working memory and cognitive flexibility [39, 47]; a further two studies only analyzed cognitive flexibility [16, 45]; and one study only evaluated WM [17]. Two studies [10, 30] considered the EF model of Norman and Shallice [28], who describe EF as a unique system of cognitive functions, named the Supervisory Attentional System (SAS).
De Bellis et al. [30] | Sustained attention. | Neglected children demonstrated a significantly worse performance in sustained attention, memory, planning and problem resolution. |
Nooner et al. [45] | Cognitive flexibility. | Boys who suffered maltreatment demonstrated worse EF performance than girls who suffered maltreatment and boys in the control group. |
Borges & Dell’Aglio [39] | WISC-III digit span forward and backward; Working memory and cognitive flexibility. | No differences were found between the groups in terms of working memory and cognitive flexibility. |
Spann et al. [16] | Cognitive flexibility. | Adolescents who suffered physical abuse and negligence showed worse performance in cognitive performance. |
Smith et al. [46] | Working memory, inhibitory control, and cognitive flexibility. | Adolescents who suffered maltreatment demonstrated worse performance in working memory, fluency, and inhibition, however, cognitive flexibility was not affected in comparison with the control group. |
Lim et al. [10] | Sustained attention. | Participants exposed to child abuse exhibited results that show that the longer the youngster suffered abuse, the worse the performance in capacity to maintain sustained attention. |
Tran et al. [17] | Operational memory. | The experience of sexual abuse and negligence throughout their lives were related to worse performance with operational memory. |
Vasilevski and Tucker [47] | WISC-IV. Working memory, cognitive flexibility, and executive function. | The results showed that the group of adolescents that suffered maltreatment demonstrated impaired EF, attention, and working memory. |
Authors, Instruments, and Results.
As far as the EF measurement instruments are concerned, it was possible to identify diversity. For the evaluation of CF, the following tests were employed:
As for the results of the articles, only one of the studies was unable to find significant correlations between maltreatment, specifically, sexual abuse and EF [39]. The remaining seven studies [16, 17, 45, 46, 47] noted impairment with EF based on the components evaluated, namely: WM, CF, and IC, as well as in attention [10, 30], in children and adolescents suffering maltreatment.
The present study, the aim of which is to carry out a literature review of the literature in respect of the impact of violence on the executive functions of children and adolescents, outlines the picture of the last 10 years’ studies on the topic, in both the domestic and international arenas.
The first issue to mention is that all the studies located investigated victimization through maltreatment; some of them specified the types (negligence, physical abuse, sexual abuse, emotional abuse, and the witnessing of interpersonal violence at home), while others considered maltreatment in a general sense. The prevalence of studies on the topic may be connected with the fact that epidemiological data indicate growing victimization through maltreatment in childhood and adolescence, as noted in Ending Violence in Childhood: Global Report [48]. Another aspect that should be considered is the typical development of the components of EF in this period between childhood and adolescence, extremely important for the processes of learning [36, 37, 38]. Thus, it has become important to investigate the situations which could interfere with this process, as is the case of violence.
The fact that there are four types of maltreatment might also explain the number of studies on this topic, as the specific studies consider sexual abuse and even physical abuse as maltreatment, including them in a single group. On the other hand, for Finkelhor et al. [5], sexual victimization is a form to be evaluated separately because sexual abuse includes lewd acts without the consent of the individual or even with the consent of children at an age when they cannot be responsible for their choices, including sexual aggression by an adult, by peers and sexually related verbal harassment. So, considering the study of victimization from Finkelhor et al. [5], sexual abuse would be in distinct study groups.
In this study, no articles were found concerning the impact of victimization through conventional crimes, violence by peers, and indirect or witnessed violence, which points to the scarcity of studies that evaluate other forms of victimization. In relation to indirect or witnessed violence, one study evaluates the impact of witnessing interpersonal violence, however, it does not include the witnessing of other forms of violence such as robberies, street attacks, and aggression between colleagues. In this sense, the results of the study conducted by Brancalhone et al. [49] indicate impairment of EF in the group of children victimized by bullying and also in those who witness it. They also pointed out that the impact of indirect violence or violence witnessed by children is evident in the course of their development, causing symptoms of depression and a drop in school performance.
As far as the evaluation of EF is concerned, only two studies [10, 30] used the model of Norman and Shallice [28], who describe EF as the Supervisory Attentional System (SAS) and, based on this, they considered sustained attention as a component of EF. The others used the model proposed by Miyake et al. [31], corroborating the literature that regards this as the model most used in both empirical and theoretical studies into EF. Just one study considered all three components, while the others used one or two components, considered responsible for the evaluation of EF. The result corroborates the literature, which is quite diverse in terms of the structure of the components [14, 26, 27], which results in complexity with the process of evaluating EF.
Despite the theoretical diversity, studies have shown that, for the most part, components of EF were impaired in children and adolescents who suffered maltreatment and only two of them presented different results. In the study by Borges & Dell’Aglio [39], girls aged between eight and 13 who suffered sexual abuse had no impairment of working memory and, in Smith et al. [46], adolescents who suffered maltreatment showed no CF impairment, but no studies were found with results that corroborate these data.
Working memory was the most studied component, appearing in four of the eight articles studied; of these four, three identified impairment with WM in children and adolescents victimized through maltreatment. Working memory is an ability essential to learning [37, 38, 50], so, the interest in investigating the impact of violence in this EF component can be justified. Studies have shown that maltreatment can impair WM in both childhood and adolescence and, consequently, the processes of learning, as well as academic performance.
As regards the instruments for EF evaluation, these are diverse, which could influence the comparison of the results found. To evaluate WM, the subtests
For the evaluation of CF, the following tests were used:
Studies show that children and adolescents are part of a vulnerable age group and, as a result, they are more subject to experiencing violence in its various forms. Self-report instruments that seek to identify the different types of violence, that is to say, those to which the children or adolescents themselves respond, are capable of analyzing the perception of living with violence in a more sensitive way or one that better approximates the extent to which this child or adolescent could be affected, and are thus considered to be more effective instruments, as they identify the perception of living with violence. In this regard, adolescents, the group with the largest number of studies, have greater capacity to identify this experience as their cognitive and emotional repertoire is better developed in terms of perception.
From childhood to adolescence, living with violence impairs the nuclear components of EF, namely working memory, cognitive flexibility, and inhibitory control, which are the basis for the development of the following complex components: planning, problem resolution, and decision-making. These components may be impaired, not to mention the processes of learning, of adaptation to situations in both cognitive and social aspects, which are characteristic of this age group, leading to difficulties that will be omnipresent in diverse situations throughout their lives.
Apart from the impairment of executive functions that the processes of victimization may cause in children and adolescents, these impairments may adversely affect the quality of life in this important age group. In this sense, a study conducted by the Center on the Developing Child, at Harvard [51], indicated that typical development in executive function skills help children to remember and follow instructions with various stages, to avoid distractions, control precipitous responses, adjust when the rules change, persist with the solution of problems and control long-term obligations which are directly associated with quality of life. Moreover, Matos et al. [13] noted that child sex abuse is negatively associated with quality of life in adulthood.
In short, the study notes the scarcity, mainly in the domestic setting, of studies investigating the relationship between living with violence and the development of EF. However, the studies that were found point out, for the most part, the impairments that living with violence may bring to the development of EF and with the processes of learning. It has become important than that future studies investigate not only experience of maltreatment but also that of other types of violence, justifying on scientific basis the need for investment in public policies that can avert living with violence, as well as in intervention policies and care for children and adolescents who are victims of violence.
From last few decades with rapid development and modernization, significant improvements in the lifestyle of humans has been observed but with pros there are associated cons and so is major depressive disorder (MDD) which is affecting teenagers to adults and majorly observed in young working professionals. It is emerging as major contributor in global disease burden and reported as the second leading causes for disability [1]. According to the study conducted by mental health in Canada, MDD has lifetime prevalence of 11.3% [2]. Besides being a major challenge for healthcare system its pathophysiology is still not uncovered completely. One hypothesis based on monoamines suggest that it may resulted from functional deficiency of neurotransmitters named serotonin and/or noradrenaline which is widely utilized for categorization of antidepressant drugs [3]. But conflict is also standstill with the time frame of the effect and dose administration as clinical symptoms are observed after several weeks from the onset of therapy and only half are noted to have actual clinical response [4, 5, 6, 7]. Apart from that one-third patients suffers from treatment resistant depression (TRD) that are nonresponsive to currently approved medications [8]. Non-responsiveness of currently available therapy especially for TRD arise the emergency need of more effective and safer antidepressant therapy.
Ketamine is a phencyclidine derivative and N-methyl-D-aspartate (NMDA) receptor antagonist, widely popular as a dissociative anesthetic. Ketamine was first reported for its efficacy in depression in year 2000, when sub-anesthetic intravenous dose of ketamine rapidly reduced the symptoms of MDD and effect continued up to 72 hours [9]. Taking lead from this, further clinical trials were conducted which showcase its efficacy in TRD patients with 60–70% response rate [10, 11, 12, 13, 14]. Onset of action was reported within 2–4 hours and last for 1 week with singe infusion while repeated infusions have effect up to 18–19 days. Clinical data also suggest the responsiveness of ketamine up to 44% on patients with comorbidities and ultra-resistant depression [15, 16]. In addition to this ketamine has been reported for its anti-suicidal and anti-anhedonic properties [14, 17, 18]. All this reports points toward the different mechanism of ketamine form traditional antidepressants.
Recently discovered antidepressant and anti-suicidal action of ketamine significantly attracted the researchers working in the field of psychiatry [9, 11, 19]. Ketamine is a phencyclidine derivative and a mixture of R(−) and S(+) enantiomers. Both R(−) and S(+) enantiomers has been explored widely and it was observed that S(+) enantiomer has higher potency than R(−) enantiomer (R-ketamine) for phencyclidine site on glutamate NMDA receptor along with stronger analgesic activity [20, 21, 22, 23, 24]. Inspired form these outputs, S(+) enantiomer also known as esketamine is now under investigations for antidepressant potential [25]. However conflict between these two is also exist with the side effects profile of both enantiomers related to dissociation, psychoses and cognition [26]. Reports suggest the rapid onset of antidepressant effects with R-ketamine but higher side effects than esketamine [27, 28, 29, 30, 31, 32, 33, 34]. Ketamine undergo metabolism through CYP2B6- and CYP3A4-mediated N-demethylation resulting norketamine which further catabolized into hydroxynorketamines (HNKs) and dehyronorketamine (Figure 1). Investigations was also carried out on metabolites of ketamine. 2R,6R-HNK has been observed to have antidepressant like efficacy with nil side effects on rat models while several contradictory reports are also available [35, 36, 37, 38, 39, 40, 41, 42, 43]. Specifically, metabolite of esketamine i.e. S-norketamine showed antidepressant like properties with lesser side effects as with esketamine [44]. When talk about bioavailability, ketamine has varying bioavailability profile with different routes i.e. 100% with intravenous, 45% with intranasal, 30% with sublingual, 20% with oral, 93% with intramuscular while 30% with rectal route [24, 30, 44].
General layout of metabolic pathway of ketamine showcasing stereoseletive metabolism through various cytochrome P450 enzymes.
Report on antidepressant efficacy of ketamine by Berman group in 2000 [9] initiated series of studies related to antidepressant activity of ketamine all around the globe. Multiple meta-analysis now established the candidature of ketamine against major depressive episodes in both bipolar as well as unipolar depression while efficacy was higher in unipolar as compared to bipolar depression [45, 46, 47, 48, 49, 50]. In addition to this, numerous studies reported its effect last up to a week only for unipolar while it is up to 3–4 days in case of bipolar depression [46, 47, 49]. Randomized Controlled trials (RCT) exist in which effect of repeated infusions of ketamine for depression is studied but there is still lack of long term trial [51, 52, 53]. Studies on different routes of administration were also conducted that majorly include intranasal, sublingual and intramuscular [54, 55, 56, 57]. In fact intranasal esketaminerecently got FDA clearance for TRD which was based on three acute-phase and two maintenance phase studies. These acute studies were conducted on severely depressed patients [58]. Maintenance trials were conducted up to 88 weeks where patient was administered esketamine weekly or every second week showcase reduced after relapse risk and also assured safety up to a year [59, 60]. A phase three trial consisted of 200 patients suggest the significant improvements in depression with ketamine adjuvant to an antidepressant [61]. There is another 5 year ongoing trial by Janssen for safety [62]. Keeping in view the antidepressant efficacy if R-ketamine, a phase I trial was started by Perception Pharmaceuticals but results are not processed yet [28].
Glutamate is one of the major excitatory neurotransmitters in central nervous system of human body that mainly acts on NMDA, ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (co-localized with NMDA) and metabotropic glutamate receptors. Glutamate activates AMPA receptors at synaptic cleft, which permit the entry of sodium ions into postsynaptic membrane. Entry of sodium ions results in depolarization of postsynaptic membrane that cause removal of NMDA receptor channel voltage-dependent magnesium ion block that activate NMDA receptor which allow the entry of sodium as well as calcium ions. Ketamine is a well-established non-competitive type NMDA receptor antagonist. Brain-derived neurotrophic factor (BDNF) and mTOR are two major proteins that are suspected to be involved in mechanistic window of ketamine. BDNF is a growth factor protein in central nervous system that promote neurogenesis and synaptogenesis along with support in survival of existing neurons. On the other hand, mTOR is suggested to have major role in neuronal development and circuit formation. mTOR further made two sub complexes known as mTOR complex 1 (mTORC1) and mTOR, from which mTORC1 is a target of ketamine [63, 64].
It has been observe that glutamatergic neurotransmission is deregulated in MDD and enhanced levels of glutamate levels in serum and plasma were observed in patient’s dealing with MDD that why plasma glutamate levels are directly correlated with severity of depression [65, 66, 67, 68]. Enhanced glutamate cause by loss of glial cells in MDD increases extra synaptic glutamate levels that suppressglutamatergic neurotransmission via activation of metabotropic glutamate receptor 2 (mGluR2) autoreceptors. A study suggest that change in depression symptoms by non-ketamine NMDA receptor antagonists like traxoprodil, lanicemine and rapastinel was much lower ass compared to ketamine [34, 69, 70, 71]. Ketamine good antagonistic activity for NMDA receptors present on γ-aminobutyric acid (GABA) that prevent activation of GABA interneurons resulting in downstream disinhibition of glutamatergic neurons that cause glutamate surge. Elevated levels of glutamate initiates activation of postsynaptic AMPA receptors that potentiate BDNF andmTORC1 signaling pathways. Ketamine demonstrated activate glutamate release and transmission in rat prefrontal cortex (RPC) [72]. Ketamine was also observed to enhance AMPA-evoked electrophysiological responses in the rat hippocampus and medial PFC pointing toward the involvement of ketamine in AMPA receptor transmission [73, 74, 75, 76, 77]. In a mouse model, ketamine was observed to increase the expression levels of two subunits of AMPA receptor known as GluA1 and GluA2 [34, 78].
Increased levels of BDNF and mTOR in rat hippocampus were observed within 30 minutes of treatment with ketamine [73, 79, 80]. Important to mention here that analgesic tramadol enhanced the effect of ketamine on force swim test along with upregulation of mTOR in the PFC and hippocampus of rat [81]. It is interesting to observe that increased BDNF and mTOR levels in hippocampal and RFC are controlled by AMPA because in a study treatment with AMPA receptor antagonist increased forced-swim test immobility time with reduced levels of BDNF and mTOR while with agonist immobility time reduced along with increased levels of both BDNF and mTOR [82]. Reports were also observed that suggest the nullification of antidepressant activity of ketamine with pre-treatment of rapamycin an mTORC1 inhibitor [83].
Numerous reports are present in the literature suggesting the possibility of ketamine’s antidepressant activity via BDNF. No antidepressant activity was observed on treatment of ketamine in genetically modified mice lacking BDNF [73]. It is proposed that antagonism of NMDA through ketamine deactivates the eukaryotic elongation of factor 2 (eEF2) kinase that de-supress the translation of BDNF. Mice having Val66Met single-nucleotide polymorphism in BDNF gene showed impairment in BDNF release and mRNA trafficking. Administration of ketamine in these mice showed reduced antidepressant activity [84]. Reversal of anhedonicbehaviour with ketamine was observed in rats with chronic mild stress along with complete restoration of dendritic atrophy and dendritiv BDNF mRNA trafficking [85]. In social defeat stress model of mice, ketamine lessen reduction in BDNF, spine density of dendrites, synaptogenesis markers (GluA1 and PSD-95) in PFC, CA3 and dentate gyrus region of hippocampus at 8th day of treatment [86]. Elevated levels of BDNF were supposed to be associated with the lower severity of depression like symptoms on rating scale [87, 88]. A study carried out on three depressed patients, suggest their response to ketamine and have increased levels of plasma mTOR expression and eEF2 phosphorylaton [89]. It is worth to note that in a trial conducted on 20 patients, pre-treatment with rapamycin tripled the response rate after 2 weeks from treatment thus may be due to targeting of rapamycin on neuroinflammation through its immunisupressant activity or may be due to promotion of haemostatsis of synaptic density (Figure 2) [90].
Flow diagram of antidepressant activity of ketamine. (1) ketamine binds with N-methyl-d-aspartate receptors (NMDARs) and reduce excitability of γ-aminobutyric acid (GABA) ergic interneurons that results, (2) non-inhibition of glutamatergic neurons, (3) that further increase glutamate release which binds with α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors resulting inflow of sodium and calcium into cell, (4) cause activation of voltage gated calcium channels, (5) that further triggers the release of brain-derived neurotrophic factor (BDNF) into glutamate synapse. (6) BDNF from synapse binds with tropomyosin receptor kinase B (TrkB) resulting activation of MEK–ERK and PI3K-Akt signaling cascades that converge on to mTOR lead to (7) increased synaptic protein translation. (8) increased proteins in synapse lead to increased AMPAR-mediated synaptic transmission causing elevated synaptogenesis. All these events are hypothesized to restore disrupted connectivity between key brain regions and can be the possible reason of rapid and sustained antidepressant action of ketamine.
D-serine is a potential co-agonist at NMDA receptor which is a possible biomarker in depression. Numerous studies highlighted the abnormality of D-serine levels in depression highlighting the antidepressant properties of D-serine [91, 92, 93, 94, 95]. Ketamine was found to inhibitor the transport of D-serine while ketamine metabolites were observed to decrease intracellular (PC-12 cells) concentrations of D-serine thus increasing plasma D-serine levels which is possible prediction related to its to antidepressant action [96, 97, 98, 99].
Ketamine also have capability to bind with opioid receptors (mu, delta and kappa), monoaminergic receptors and transporters, and muscarinic and nicotinic cholinergic receptors [100]. Proposition is made that anti-suicidal as well as antidepressant actions of ketamine is related to the opioid system which is confirmed from the pre-treatment of naltrexone after that antidepressant effect was attenuated in patients [100, 101]. However many discrepancies are also exist along with [102, 103] because buprenorphine and methadone both are agonists to the opioid receptors and does not have any effect on antidepressant properties of ketamine [103]. These results rebels the role of opioid system in ketamine’s antidepressant effects. Thus role of opioid in ketamine’s antidepressant effects is yet unclear and controversial.
With unique mechanism of action as compared to traditional antidepressants along with anti-suicidal properties, ketamine successfully attracted the researchers and physiologists toward itself in last two decades. However large mechanism of actions are still need to uncover thus it will be continue to be a hot topic and active area of research in psychiatry. There if a dire need to investigate the appropriate safety to efficacy ration of ketamine in depression therapy along with establishment of appropriate regimens for maintenance of therapy and discontinuation too. Reliable biomarkers are also needed to properly predict the response and adverse effects of ketamine. Numerous reports are also present in literature that caution the utilization of ketamine as an antidepressant in clinical practice [76, 104, 105, 106, 107, 108]. Keeping these thing apart, currently ketamine is emerging as a promising approach for treatment of patients suffering from TRD. Ketamine and its related neurochemical biomarkers can act as leads for development of future antidepressants.
Rapid antidepressant effect of ketamine depression therapy and important discovery in depression research. Its efficacy against TRD and anti-suicidal potential is a boon in depression research but at the same time its negative side effects and potential for being abuse is not to be neglected. However pathways like BDNF, mTOR, AMPA along D-serine and opioid receptors provided sufficient understanding but large portion of its mechanisms are still need to uncover. Even some studies create conflict to each other which is needed to be resolved. Overall analysis suggest that there is an important need to discover all aspects of ketamine in depression therapy to efficient use of this drug as an antidepressant in clinical practice. Moreover, ketamine can act as a lead for the development of new class of rapidly acting future antidepressant agents.
The authors are also thankful to Guru Nanak Dev University, Amritsar for providing various facilities to carry out the work.
The authors declare no conflict of interest.
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Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. 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MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. 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Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. 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Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:4,paginationItems:[{id:"81821",title:"Pneumococcal Carriage in Jordanian Children and the Importance of Vaccination",doi:"10.5772/intechopen.104999",signatures:"Adnan Al-Lahham",slug:"pneumococcal-carriage-in-jordanian-children-and-the-importance-of-vaccination",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"81813",title:"Schistosomiasis: Discovery of New Molecules for Disease Treatment and Vaccine Development",doi:"10.5772/intechopen.104738",signatures:"Andressa Barban do Patrocinio",slug:"schistosomiasis-discovery-of-new-molecules-for-disease-treatment-and-vaccine-development",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{},onlineFirstChapters:{paginationCount:18,paginationItems:[{id:"81778",title:"Influence of Mechanical Properties of Biomaterials on the Reconstruction of Biomedical Parts via Additive Manufacturing Techniques: An Overview",doi:"10.5772/intechopen.104465",signatures:"Babatunde Olamide Omiyale, Akeem Abiodun Rasheed, Robinson Omoboyode Akinnusi and Temitope Olumide Olugbade",slug:"influence-of-mechanical-properties-of-biomaterials-on-the-reconstruction-of-biomedical-parts-via-add",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}},{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"25",type:"subseries",title:"Evolutionary Computation",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios",profilePictureURL:"https://mts.intechopen.com/storage/users/111683/images/system/111683.jpg",institutionString:"De La Salle University",institution:{name:"De La Salle University",institutionURL:null,country:{name:"Philippines"}}},{id:"106873",title:"Prof.",name:"Hongwei",middleName:null,surname:"Ge",slug:"hongwei-ge",fullName:"Hongwei Ge",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Dalian University of Technology",institutionURL:null,country:{name:"China"}}},{id:"171056",title:"Dr.",name:"Sotirios",middleName:null,surname:"Goudos",slug:"sotirios-goudos",fullName:"Sotirios Goudos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9IuQAK/Profile_Picture_1622623673666",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"15895",title:"Assistant Prof.",name:"Takashi",middleName:null,surname:"Kuremoto",slug:"takashi-kuremoto",fullName:"Takashi Kuremoto",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLrqQAG/Profile_Picture_1625656196038",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}},{id:"125844",title:"Prof.",name:"Wellington",middleName:"Pinheiro Dos",surname:"Santos",slug:"wellington-santos",fullName:"Wellington Santos",profilePictureURL:"https://mts.intechopen.com/storage/users/125844/images/4878_n.jpg",institutionString:null,institution:{name:"Federal University of Pernambuco",institutionURL:null,country:{name:"Brazil"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/80511",hash:"",query:{},params:{id:"80511"},fullPath:"/chapters/80511",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()