\r\n\tThis book chapter’s main theme will be focused on transmission dynamics, pathogenesis, mechanisms of host interaction and response, epigenetics and markers, molecular diagnosis, RNA interacting proteins, RNA binding proteins, advanced development of tools for diagnosis, possible development of concepts for vaccines and anti drugs for RNA viruses, immunological mechanisms, treatment, prevention and control. \r\n\t
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1. Introduction
“Understanding psychosis” is in itself a contradictory remark, because psychosis is defined as an “un-understandable” entity. As is well-known, “understanding” in classic psychopathology has a special meaning which differentiates psychosis from neurosis defined as psychogenic symptoms. As neurotic symptoms like anxiety or phobia are “understandable”, that is, imaginable and relivable on the basis of normal mental life, they can be thought of as quantitative extremes of normal mental activities, and therefore can be treated psychologically. In contrast, psychotic symptoms like hallucinations or delusions are qualitatively different from normal mental activities and cannot be imagined as their quantitative extremes. This qualitative difference should be considered as a marker of the existence of pathological processes in the patient’s brain.
While nowadays various neurotic disorders which had been considered as psychogenic have turned to be thought to have some neural basis, psychotic symptoms still remain a special group of symptoms, which indicate difficulty for purely psychological treatments. Therefore, “understanding” still remains an important clinical methodology, although it is entirely subjective and fairly ambiguous. This chapter reviews and examines the implications and possibilities of the concept of “understanding” for clarifying what is psychosis.
2. Understanding and Jaspers
The concept of understanding in the specialized sense is introduced in psychiatry by Karl Theodor Jaspers (1883–1969), who was a German psychiatrist and later an existential philosopher, but it is not he who invented it. This methodological concept was introduced in order to distinguish the method of history from that of natural sciences by German historian Johann Gustav Bernhard Droysen (1808–1884). Then German philosopher Wilhelm Christian Ludwig Dilthey (1833–1911) adapted it from history to psychology. Dilthey endeavored to establish a methodological basis of human sciences (Geisteswissenschaften in German) and proposed understanding (Verstehen) as the distinct and essential methodology of them, opposed to explanation (Erklären) characteristic of natural sciences. Understanding is a subjective method based on empathy and imagination, contrasted with that explanation is an objective method based on some theory or logical interpretation.
Because psychiatry is not a pure natural science like other disciplines of medicine, but an interdisciplinary field comprising natural, human and social sciences, it was reasonable that Jaspers adopted understanding as a principal method of psychiatry, besides causal explanation. In the monumental textbook “General Psychopathology (Allgemeine Psychopathologie)” [1, 2] (abbreviated as GP in the following), he urged psychiatrists to consider the difference between psychical symptoms and somatic symptoms, that is, the former is subjective and the latter is basically objective. Causal explanation can only be applied to objective phenomena and so-called “psychological explanation” should exactly be called understanding as far as it is purely subjective.
At the time Jaspers published the first edition of GP in 1913, he was facing and had to oppose the then propagating influence of psychoanalysis. He pointed out the methodological weakness of psychoanalysis in various ways and characterized it as “pseudo-understanding” or “as-if-understanding (Als-ob-Verstehen)” in which plausible but fictitious interpretation is mistaken for understanding (GP, pp. 306–7).
It is important to note that Jaspers also emphasized the limitation of understanding. He writes, it is not that the psyche can only be understood and cannot be causally explained, but it can also be explained. While explanation has no limits, as it continues to widen the range in proportion to the progress of neuroscience, “with understanding there are limits everywhere” (GP, p. 305), as it is only based on our innate ability of empathy and imagination. Also, he writes, “Understanding by itself does not lead to any causal explanation except in indirect fashion when it happens to come up against the un-understandable” (GP, p. 305). In other words, understanding indicates the existence of a pathological process in the human psyche not by its ability but by its inability. This is the seemingly paradoxical feature that makes the concept of understanding look somewhat confusing, but also makes it unreplaceable by any other concepts.
3. Psychosis as the un-understandable
There are common misunderstandings of Jaspers’ characterization of psychotic disorders as the “un-understandable”. Some clinicians take un-understandability for disorder of communication often seen in chronic cases of schizophrenia. As such cases often show thought disorder in which logical and verbal rules appear disrupted, resulting in difficulty of communication with others, the expression “schizophrenia is un-understandable” might often be misunderstood as describing such a situation. However, the right meaning of “schizophrenia is un-understandable” is that psychic phenomena characteristic of schizophrenia cannot be imagined and relived by healthy people. “Understanding” of Jaspers’ meaning is not at all related to logical or verbal thinking.
Another misunderstanding of the un-understandability of psychosis is that it is taken for indicating the impossibility of scientific elucidation of psychosis or schizophrenia. Whereas Jaspers was critical about the premature adoption of the biological explanation of psychotic disorders, accusing such attempts as “brain mythologies” (GP, p. 18), he did not deny the possibility of the future success of such scientific research for the cause of psychosis in the brain. In fact, his characterization of psychosis as the un-understandable implies the necessity of biological research, because when understanding faces limitations, he writes, “each limitation is a fresh stimulus to formulate the problem of cause anew” (GP, p. 305). Jaspers believed that schizophrenia should have some biological cause, which is gradually appearing as un-understandable symptoms and eventually bringing the person into a sterile deficient state.
Psychosis in the meaning of Japers is not confined to schizophrenia. It includes mood disorders, although in the classical definition of the cyclic appearing of severe affective symptoms. While the diagnostic criteria of mood disorders have been significantly broadened since his era, resulting in the inclusion of people without any psychotic nature, Jaspers’ definition of mood disorder was much narrower, confined to severe depression (melancholy) and bipolar disorders (manic depressive illness). He characterized it as psychosis, not because of the existence of hallucinations or delusions like modern operational diagnostic systems, but because of un-understandability in the same meaning as schizophrenia.
What is, however, the sameness between schizophrenia and severe mood disorder, if it is not the existence of hallucinations or delusions which are un-understandable symptoms? It might be said that those two have disorders in reality testing in common from the behavioral viewpoint. While, from Jaspers’ viewpoint of understanding, because the experience of mood disorders is fairly understandable on the basis of normal affective life, it seems to differ from schizophrenic experience that is un-understandable. Un-understandability of mood disorders exists not in the mood itself, but in its manner of appearance. That is, affective symptoms in mood disorders appear cyclically with a certain period like automatic machinery, almost not at all related to incidents in mental life. Patients feel sad or cheerful for a certain duration without any incidents that are understandable by others to induce those affects. This is the meaning of un-understandability of mood disorders.
The two major types of psychosis, schizophrenia and mood disorders are thus defined as the “un-understandable”. Then another question might arise: why there are only two types in psychosis? The author’s answer is based on Kraepelin’s principle of dichotomy, that is, disease process without regard to pathogenesis could only be classified into two forms, chronic-progressive and acute-recurrent. In addition, the chronic-progressive process implies gradual diffusion and the acute-recurrent process does localized irritation. Therefore psychosis also should be classified almost necessarily into two corresponding forms, chronic-diffuse and acute-local, whose actualizations are schizophrenia and mood disorders respectively. Thus the “un-understandable” manifests itself as gradually permeative in schizophrenia, whereas in mood disorders it does as mechanically cyclic.
4. Psychosis, responsibility, and self-understanding
One reason, and the most important one from the sociocultural viewpoint, why the psychopathological distinction between psychosis and various psychogenic states should be defined is that it matters forensic judgments on responsibility for illegal acts. A person afflicted with the severe psychotic disorder would not be punished because of a lack of responsibility for illegal acts, which are supposed to have been executed by lack of reason resulting from the disorder.
Here it is to be clarified what is lack of reason because the meaning of the word “reason” is quite ambiguous. Concretely, it can be classified into three categories. The first is the insufficiency of the ability for distinguishing right from wrong, which is represented by people with intellectual disabilities or dementia virtually equated with children. The second is acute confusion with impairment of consciousness, which can be induced by intoxication by alcohol or other psychotropic substances, and also by epileptic disorders. In principle, memories of the behavior are disturbed in these cases. The third category is the most complicated cases, namely, people with schizophrenia or delusional disorders, who are with sufficient ability for telling right and wrong, and without any impairment of consciousness.
Then, what is the reason why people with schizophrenia or delusional disorders are thought “without reason”? It is because their delusions are, although often wrong in content, never correctable by any factual evidence or sincere persuasion. In other words, the patients lack the ability of “reality testing”, as they take their delusions as more real than the reality shared by others intersubjectively.
However, an important question remains: what is the difference between the delusions of the patients and queer thoughts held by, for example, religious minorities? Is it that whereas a psychotic delusion is held only by a patient, a religious belief is held by, however small it is, a collective? However, this question is ultimately insoluble, because there is always a possibility of the existence of co-believers of the thought, especially in the contemporary setting in which queer religious and other kinds of thoughts are scattered and pervading through the internet without forming any physical collective.
It is, therefore, necessary to define the essential deficit of the patients with psychotic delusions, which justifies the lack of responsibility, without being based on the content of the belief. The concept of understanding is here again useful as shown in the following.
Let us think about a typical legal case of a person with schizophrenia. He committed a kind of crime, for example, violence against a woman. He accepts that it is a fact that he executed brute force on her, but he does not accept that it was directed by his intention. He does not mean that it was an accident or a mistake, and he has a clear memory about the violence he employed. What he insists is that whereas the violence was executed by his body, it was directed by another person’s intention, that is, the agent of his body was not himself at that time. It is a quite irrational statement, which describes an un-understandable experience that we, the psychically healthy, cannot relive or imagine.
The reason why delusional patients should be thought irresponsible is, however, not the fact itself that their experience during the criminal acts is un-understandable by the healthy people. If it was the reason, it would be in effect the same situation as the queer thoughts held by the minorities. The true reason is the fact that the patient himself cannot understand his own intention. Our voluntary acts are based on our intentions and the connection between our intentions and our acts is always understandable without any verification, which is the basic fact for the responsibility. In the psyche of people with schizophrenia, however, the connection is broken and becomes un-understandable, so that the agent of his acts is lost and found in another, often undesired horrible person. Therefore the patient was himself horrified when he executed the violence. In this way, the un-understandability of the insistence of people with psychotic disorders stems from the un-understandability of their own intentions, so to speak, a disorder of self-understanding.
5. Self-understanding as the basis of self-disorder
Disorder of self-understanding has much broader significance than that has within the range of forensic psychiatry. With regard to general psychopathology of schizophrenia or psychosis, it could be thought to constitute the basis of various “bizarre” hallucinations and delusions, generally called ego disorder (Ich-Störung) or self-disorder, for example, verbal hallucinations criticizing or commenting on the patient, passivity phenomena and delusion of observation. Although Jaspers characterized schizophrenia as the un-understandable and therefore incomprehensible, it seems rather consistently comprehensible from the viewpoint of self-disorder, as once Kurt Schneider (1887–1967) and lately phenomenological psychopathologists have maintained [3, 4, 5].
Whereas the self is what should be the most understandable for us, because it is the very basis of the understandability of the world which we live in, nevertheless, it becomes un-understandable for the patients with schizophrenia. When the self is un-understandable, all the percepts coming in from the outside or even from inside the body become mysterious and alienated, resulting in the entire world being opaque and un-understandable. Furthermore, they cannot effectively respond to and resist the situation, because their own intention also becomes alienated, remaining their bodies impotent and paralyzed. Thus various bizarre and un-understandable complaints and disorganized behaviors that the patients show are to be comprehended as manifestations of the predicament into which they are being fallen and their desperate striving against it.
6. Summary
Modern operational diagnostic system like DSM-5 lacks the essential concept for defining psychosis [6]. Understanding and un-understandability are, although somewhat confusing because of the paradoxical feature, and too ambiguous from the viewpoint of operationalization, still necessary concepts for psychiatrists to make clinical practice effectively. Also, there seems to be a need for the development of the concept of self-understanding, based on that of understanding, for deeper comprehension and more sensible treatments of psychotic patients.
\n',keywords:"psychosis, understanding, un-understandability, Jaspers, self-understanding",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/79854.pdf",chapterXML:"https://mts.intechopen.com/source/xml/79854.xml",downloadPdfUrl:"/chapter/pdf-download/79854",previewPdfUrl:"/chapter/pdf-preview/79854",totalDownloads:112,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:0,impactScoreQuartile:0,hasAltmetrics:0,dateSubmitted:null,dateReviewed:"November 29th 2021",datePrePublished:"December 29th 2021",datePublished:"February 2nd 2022",dateFinished:"December 29th 2021",readingETA:"0",abstract:"“Understanding” in Jaspers’ sense is the essential concept for defining psychosis, although its relationship is paradoxical, that is, psychosis is defined by un-understandability or inability to understand. Un-understandability means the inability of empathizing with the patient’s mind and implies the existence of a pathological process in the patient’s brain. The pivotal concept which makes psychotic patients be judged as irresponsible in forensic cases is disturbed self-understanding or un-understandability of their own intentions. It is suggested that self-disorder representing psychosis might be based on disturbed self-understanding.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/79854",risUrl:"/chapter/ris/79854",book:{id:"7829",slug:"psychosis-phenomenology-psychopathology-and-pathophysiology"},signatures:"Kenjiro Fukao",authors:[{id:"32519",title:"Dr.",name:"Kenjiro",middleName:null,surname:"Fukao",fullName:"Kenjiro Fukao",slug:"kenjiro-fukao",email:"fukao@tezuka-gu.ac.jp",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32519/images/system/32519.png",institution:{name:"Tezukayama Gakuin University",institutionURL:null,country:{name:"Japan"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Understanding and Jaspers",level:"1"},{id:"sec_3",title:"3. Psychosis as the un-understandable",level:"1"},{id:"sec_4",title:"4. Psychosis, responsibility, and self-understanding",level:"1"},{id:"sec_5",title:"5. Self-understanding as the basis of self-disorder",level:"1"},{id:"sec_6",title:"6. Summary",level:"1"}],chapterReferences:[{id:"B1",body:'Jaspers K. Allgemene Psychopathologie. Fünfte unveränderte Auflage. Berlin Heidelberg GmbH: Springer-Verlag; 1948'},{id:"B2",body:'Jaspers K (Hoenig J, Hamilton MW, trans.). General Psychopathology. Baltimore: Johns Hopkins University Press; 1997'},{id:"B3",body:'Schneider K (Hamilton MW, trans.). Clinical Psychopathology. Oxford: Grune & Stratton; 1959'},{id:"B4",body:'Parnas J, Handest P. Phenomenology of anomalous self-experience in early schizophrenia. Comprehensive Psychiatry. 2003;44(2):121-134'},{id:"B5",body:'Fuchs T. The self in schizophrenia: Jaspers, Schneider, and beyond. In: Stangellini G, Fuchs T, editors. One Century of Karl Jaspers’ General Psychopathology. Oxford: Oxford University Press; 2013. pp. 245-257'},{id:"B6",body:'Parnas J. On psychosis: Karl Jaspers and beyond. In: Stangellini G, Fuchs T, editors. One Century of Karl Jaspers’ General Psychopathology. Oxford: Oxford University Press; 2013. pp. 208-228'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Kenjiro Fukao",address:"fukao@tezuka-gu.ac.jp",affiliation:'
Faculty of Human Science, Department of Psychology, Tezukayama Gakuin University, Japan
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1. Introduction
Goats are small ruminants that were among first domesticated farm animals which are into herding from about 10,000 years ago [1]. The acclimatising capacity of goat is peculiar as they can be economically reared in areas ranging from tropics, deserts, temperate to harsh climate of mountains without fluctuation in productivity [2]. Goat is a major supplier of dairy and meat products for rural people and regarded as a “Poor man’s cow” [3].
The world’s goat population has increased by around 55% from 1991 to 2011 whereas cattle population grew only by 9% and sheep population decreased by about 7%. In between these years Goat’s milk (GM) production increased by around 70% [4] which can however be greater because of unreported home consumption of GM in large amount in case of developed countries [5]. The production of GM in world showed an increase of 62% from 1993 to 2013 from 11 to 18 million tons [6]. Except in Antarctic, GM consumption by human is found in all over the world [6]. The contribution of developing countries in goat rearing is noteworthy. Out of total goat population more than 90% alone is maintained by countries in Asia and Africa [7]. Majority of goats including dairy ones in Asia are in the hands of small-scale farmers, among which many of them are poor and landless [8]. The production and consumption pattern of GM and its products has increased in recent decades. Growth in consumption of such milk products is due to their known beneficial effects on human health which are already recognised by the scientific community (Table 1).
Total annual milk supply of goat is about 3.4%, sheep milk is 1.4%, camel milk is 0.2%, cow milk is 85% while buffalo contribute 11% [9]. About 80% of total GM supply is only from Asia [3] of which main countries include India, China, Bangladesh, Iran, Pakistan and Turkey [10]. 36.7% of world dairy goats are reared in Indian subcontinent producing 40.7% of the world’s goat milk, with India (60.6%, 129 L/doe), Bangladesh (16.9%, 37 L/doe) and Pakistan (13.3%, 100 L/doe) [11]. Out of 500 breeds of goat only half dozen is raised for milking purpose and about 600–700 million dairy goats are present in the world (Figure 1) [12].
Figure 1.
World goat milk production trends from 1916 to 2016 (solid line) and forecast to 2030 by using time series model (dashed line). Source: Ref. [7].
The major species of milching dairy goat includes Sannen, Anglo-nubian, Toggenburg, British alpine. They produce good quantity of milk. For an instance Toggenburg can produce 7.57 litres of milk per day [13]. Factors like breed, season of kidding, stage of lactation, species, age, parity, colostrums, feed, environmental conditions, length of dry period, disease, body weight etc. can cause change in GM composition [14].
Milk is clean lacteal secretion from mammalians shortly after parturition. GM being highly compatible and nourishing complete natural food, can serve as a substitute for a meal. Its acceptability has increased in recent years which is mainly due to its low fat and capacity to neutralize acids and toxins present in body and also due to higher gross composition than that of cow’s milk. GM has potential that enable tolerating different technological treatments to obtain a product which have ability to satisfy the demand of consumer in terms of health, nutrition, safety and pleasure. Beside qualitative criteria (colour and odour), other aspects should also be given equal importance (milk protein, fat, bacteriology, freezing point, lipolysis, somatic cell count, immunoglobulins, inhibitors etc) for improving the quality of milk [15]. Human milk consumption as defined by the International Congress of Food “milk is the product of the total, full and uninterrupted milking of dairy female in good health, also nourished and not overworked”. It must be collected properly with no colostrum [16].
GM can be consumed as an alternative to cow milk as it is less allergenic [17] and highly digestible [18]. It has been reported by Park (1994) that between 40 and 100% of patients allergic to cow milk proteins can tolerate GM. It is also recommended to pregnant women and infant to fulfil their nutritional requirement at growing stage [19] and also to old and convalescent people [20]. It is immune to several diseases and boost the immunity system of human. It differs from cow and human milk as it shows distinct alkalinity, higher buffering capacity and certain therapeutic values in medicine and human nutrition. The nutritional and health benefits of GM are related to a number of medical problems, the most important being food allergies and a pure substitute for those who are allergic to cow milk (Figure 2) [22].
Figure 2.
Goat milk production in the world from 2000 to 2013 (million tons). Source: Ref. [21].
2. Methodology
This review chapter is a compilation of numerous research and review paper. In the course of writing this chapter we have reviewed number of articles, proceedings, magazines, newspaper, bulletin, editorial etc, Solids so that a broad range of information could be collected and presented. So, this is a thorough and detailed information regarding goat milk and its nutritive as well as medicinal values, accordingly which its conclusion has been drawn.
3. Composition of GM
GM because of its specific composition is being considered as a high-quality raw material for manufacturing food of infants along with population with particular needs [23]. Fresh goat milk appears as a white, opaque liquid with a little sweet in taste having no odour in practical life [24]. The Solid content in goat milk ranges from 12 to 18% while protein content in solid lies between 3 and 4.5% in goat milk [25]. Compositional and nutritive value of goat milk can be preserved, enhanced and improved by the aid of processing [26].
The composition and milk yield of goat varies with varying factors such as diet, breed, management, environment, age, stage of lactation, season, plane of nutrition etc. [27]. GM having all the composition in adequate amount is preferred as a high-quality milk and it should be free from pathogens and foreign substances such as antibiotics, antiseptics or residue of pesticides and should not differ from that of cow’s milk in taste and odour. GM is proven to have a better and efficient digestibility, buffering capacity, alkalinity and therapeutic values as compared to human and cow’s milk in human nutrition and medicine [28].
3.1 Fat
The physical properties like surface tension, viscosity and specific gravity of GM are higher in comparison with cow milk [17]. The fat globules of GM are smaller than bovine milk. The smaller sized fat globules allow dispersion and more homogeneous mixing of fat in milk. The average diameter of globules in GM ranges from 1.5–2 μm while that of cow’s milk ranges from 2.5–3.5 μm [24] which is the reason behind GM to be known as “self homogenised or naturally homogenised milk”. Having smaller fat globules and greater surface area facilitate GM to be more digestible than cow milk as total surface area of globules gets effectively connected with the lipids [29]. Also, lipases in the gut tentatively attack the lipids ester linkages in the short chain fatty acids more readily and rapidly helping in faster digestion of GM [30]. GM is enriched with higher proportion of short and medium chain fatty acids, mostly butyric, palmitic, caproic, capric, caprylic, linolenic, alpha- linolenic, lauric, myristic acid while lower in longer chain fatty acids like oleic and stearic [23]. Among these 3 (Capric, Capryllic and Caproic) have been named after goat because of their predominance in GM [31].
3.2 Protein
Milk is composed of casein and whey protein where casein (alpha s1, alpha s2, beta and Κ-caseins) represent 80% of proteins while rest part is filled by major whey proteins (alpha-lactoglubulin and alpha-lactalbumin) [32]. The major protein in cow milk is alpha s1 casein while in GM it is beta casein. One of the most representative free amino acid in GM is Taurine [33] which is higher in GM as compared to cow milk [34]. Out of 10 essential amino acids 6 (threonine, isoleucine, lysine, cystine, tyrosine, valine) are found in high amount in GM than in cow milk [35]. Main reason behind the low amount of folic acid in GM is that it contains high concentration of folate binding protein making it unavailable for human to digest and absorb. The heavy fat content and mucus-producing components of cow milk are absent in GM and it is complete source of proteins containing all essential amino acids [36, 37]. Fragments of GM caseins have been found to possess antimicrobial peptides that shows strong activity against gram negative bacteria [38].
3.3 Vitamin
The content of Vitamin A in GM is higher than in cow milk as goat convert all beta carotene from foods to Vitamin A (retinol) in milk which is the reason for whiter GM and milk fat [17]. Also, higher casein content is GM promotes the same [39]. It contains 25% more Vitamin B6, 47% more Vitamin A than cow’s milk and it mainly possesses Vitamin A2 [40]. Content of Vitamin D of both GM and cow milk is similar that is mostly needed during infancy (Table 2) [41].
Vitamin
Goat milk
Cow milk
Vitamin A (IU)
185
126
Vitamin D (IU)
2.2
2.0
Thiamine (mg)
0.068
0.045
Riboflavin (mg)
0.21
0.16
Niacin (mg)
0.27
0.08
Pantothenic acid (mg)
0.31
0.32
Vitamin B6 (mg)
0.046
0.042
Folic acid (ug)
1.0
5.0
Biotin (ug)
1.5
2.0
Vitamin B12 (ug)
0.065
0.357
Vitamin C (mg)
1.29
0.94
Table 2.
Composition of vitamin (per 100 g) of goat and cow milk.
Major carbohydrate in GM is Lactose whose content is slightly lower in GM than in cow’s milk [42]. Lactose, a valuable nutrient favours intestinal absorption of calcium, phosphorus and also in proper utilisation of vitamin D [31]. It is crucial for milk synthesis and during secretion of milk in the duct system of udder [5]. As compared to cow milk, GM contains surplus amount of lactose derived oligosaccharides. Other carbohydrates that are present in small amount includes oligosaccharides, glycopeptides, glycoproteins and nucleotides [42]. GM oligosaccharides are thought to be exhibiting the anti-inflammatory effects in induced colitis [43]. GM oligosaccharides are especially beneficial for infants due to their prebiotic and anti-infective properties (Table 3) [45].
Component
Cow milk
Goat milk
Human milk
Protein
3.58
3.52
1.63
Fat
4.14
4.25
3.75
Total solids
13.19
13.00
12.57
Solids not fat
9.25
7.75
8.82
Lactose
4.96
4.27
6.98
Ash
0.71
0.86
0.21
Table 3.
Average composition of cow, goat and human milk (%).
GM contains major and trace minerals that includes Ca, Na, Mg, P, K, Zn, Mn, Se, Cu, Co, Fe which have great health benefits. Percentage of Zn in GM is higher than in cow’s milk that is responsible for maintaining healthy skin, healing of wound, act as antioxidant and eliminate reactive oxygen species via its role as a cofactor for antioxidant enzyme superoxide dismutase (SOD). Mineral content in GM is higher than that of human and cow milk ranging from 0.7 to 0.85% [46]. GM contains 13% more calcium than cow’s milk per serving and 134% more potassium [47]. Selenium content in goat and human milk is higher than that found in cow milk [48]. The Selenium in GM plays a key role in acting as a cofactor for the functioning of glutathione peroxidase (GPX), an antioxidant enzyme which scavenges harmful free radical in body and helps in macrophage activation (Table 4) [49].
Because of the highest nutritional value, GM is preferred over cow and buffalo milk [50]. The nutritional and health benefits of GM are directly related to the medical problems that are faced by people of which main being allergies towards milk proteins obtained from cow’s milk [51]. It provides 70 calories per 100 ml. The superior digestibility of GM, its proper fatty acid composition and content of bioactive compounds seem to give those properties to it that help in treating or preventing certain medical conditions. Bioactive peptides derived from milk plays vital role in human health and nutrition. The most vulnerable ones are infants, aged people and pregnant women as their immune system could answer at any time if extra supplement is not administered.
The amount of calcium and phosphate supplied from GM is of much importance to human nutrition. It contains 1.2 g calcium and 1 g phosphate per litre which is higher than that contained in human milk. So, GM offer excess of calcium and phosphorus to human infant that is easily absorbed by them [30]. GM supply adequate amount of Vitamin A and niacin to human infant. Though it supplies excess of thiamine, riboflavin and pantothenic acid [5, 30] it is deficient in terms of Vitamin C, D, B12, pyridoxine and folate [52]. So, these nutrients should be supplied at the time of infant feeding by applying appropriate fortification. American Academy of Paediatrics forbade the use of GM products for infants under one year mainly because they can cause intestinal irritation and anaemia. Infants of such age who are allergic to cow’s milk-based formulas are only fed on goat’s milk formula after properly consulting baby’s doctor or paediatric nutritionist [53].
One of the reasons that consumers are accepting GM and its products in an appreciable manner is due to its nutritive value. It is beneficial in maintaining health, physiological functions, in the nutrition of child and elderly ones [54]. It is reported that it contains off flavour. This is due to the fact that membranes around fat globules in GM are more fragile which may relate to their greater susceptibility in developing off flavour than in cow milk. However, fresh milk obtained under sanitary conditions from properly fed and hygienically managed goats is found to be free from such objectionable flavour and odour [55].
Cow’s milk is reported to be mucus forming for many people but goat milk is not only non-mucus forming but also help in neutralising the mucus. GM has been a viable alternative for those children who are having difficulties in digesting cow’s milk as it is second best option, first being mother’s milk. The composition of goat and human milk is almost similar. Children who drink goat milk tend to remain more satisfied between meals and sleep through the night [56]. 2.5% of infants during first 3 years of their life suffer from cow milk allergy [57] while this percentage rise from 12 to 30% for infants who are less than 3 months old [58]. Not just for infants but also for adults and nursing mother, GM has been good alternative because of its unique properties. GM is rich in vitamins, minerals, trace minerals, enzymes, protein, fatty acids and amino acids (especially tryptophan) that are easily utilised by human body. The greatest advantage of consuming GM by many people lies in the fact that those who cannot digest cow’s milk find it easy in digesting GM without any complications. The reason for this is yet to be known but it is thought that this action in GM is due to lower lactose content (7% less than that of cow milk). There is one fact which says that our body takes 20 minutes to digest GM while it takes 2–3 hours in digesting cow’s milk [56].
Conjugated Linoleic Acid (CLA), an important bioactive component is naturally found in GM which helps in immune response stimulation. Mediators of immunity such as cytokines, prostaglandins, immunoglobulins etc, are modified by the action of CLA. The CLA possess ability to reduce the allergy related immunoglobulin IgE in humans that suggest anti-allergic potential of lipid [38]. The richness of GM in Medium Chain Triglycerides (MCT) helps in improving nutrients absorption and energy production in the body. MCT along with other amino acids exhibits antimicrobial activity [59].
Taurine (free amino acid) performs different roles in human body such as growth and brain development, formation of bile salts, calcium flux modulation, stabilisation of membranes as an osmoregulation by attenuating toxic substances. Its deficiency in human tissues may be the result of cardiomyopathy, epilepsy, lack of growth etc. [60]. In case of animal studies, Taurine is suggested as an important amino acid in alleviating muscle fatigue and can build up exercise capacity during workouts [46].
Amount of Vitamin A contained in GM is similar to human milk which is crucial for innate and adaptive immune responses that also includes cell-mediated immunity and antibody responses as well. Deficiency of this vitamin leads to decreased innate immunity that will affect NK cell function and phagocytic activity. Vitamin D plays an important role in the immune system and help preventing infections, autoimmune diseases, cancer and diabetes. Vitamin C which is present in greater amount in GM than in cow’s milk has shown to affect many aspects of the immune system including regulation of immunity via antiviral and anti-oxidant properties [49].
As compared to cow’s milk GM has higher content of Ca, P, K, Se, chloride, Zn, Cu [61, 62]. Potassium is crucial in acid/base balance and also in the proper functioning of muscles, nerves and kidneys. Chloride maintains fluid balance, blood pH and osmotic pressure. Calcium and phosphorus strengthen the structure of bones, muscles and help in blood coagulation. Selenium is vital in protecting cell against free radicals and also it acts as a major component in preventing dengue fever. Copper helps in metabolism of iron and oxygen and also defence the cell against free radicals [49].
5. GM medicinal value
Multivitamins, proteins, minerals (including trace one), fatty acids as well as Lactic acid bacteria in GM help in fighting human against diseases including diarrhoea, vomiting, constipation, gastric discomfort, respiratory disorders and many other [20].
5.1 Prevention of dengue fever
Dengue fever which is transmitted by the bite of Aedes aegypti mosquito is of great problem in tropical countries. Each serotypes of dengue virus (DEN 1, 2, 3 and 4) are equally responsible to cause severe dengue and haemorrhagic syndrome [63]. Ferropenic anaemia and bone demineralization were better recovered with GM. Dengue is endemic in 112 countries of the world [64]. Regular consumption of GM is suggested by doctors in case of dengue fever because it is necessary to maintain body fluid balance and also transfusion of platelets is not possible in all cases. If platelet level drops (below 20,000) and there is significant bleeding then platelet transfusion should be provided. Selenium (Se) which is present in GM act in preventing dengue. GM have more than 2.5 times the Se powdered infant formula (19.98 mg/L vs. 7.47 mg/L) as compared to cow milk and nearly 35% greater than pasteurised cow milk (19.98 mg/L vs. 14.85 mg/L) [65]. As compared to cow milk GM possesses 27% more Se [33]. Se if become deficient can cause an irreversible cardiomyopathy [66]. Se helps in controlling the human immune system in case of autoimmune disease by upgrading it when necessary and degrading it when it is overactive. Se has anticlotting effect while thrombotic and pro-clotting effects are due to its deficiency. The replication of dengue virus is prevented by Se. T cell and interleukin both are vital component of immune system and Se help by modulating the production of interleukin or by increasing the T cell function [67]. In treatment of dengue fever GM and its products are very helpful as they directly modulate human immune system. Immune response and antioxidant protection of host can be significantly improved by the incorporation of Se as selenocysteine in GPx [68]. Deficiency of Se can be prevented by having pills and animal products that contain Se [69].
5.2 Antimicrobial properties
Proteins derived from milk are proved to be precursors of antimicrobial peptides. GM have been reported to have antimicrobial activity of several pathogenic bacteria that are contained in food materials. GM caseins fragments are good source of antimicrobial peptides that are effective against gram negative bacteria [38]. Alpha-S2 Casein (CSN1S2) in GM is studied for its antimicrobial property. The result indicated that this caprine protein has inhibition activity that opposes the pathogenic bacteria by optimal concentration of 5 mg/ml in all bacteria especially Gram positive (Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus) and negative (Escherichia coli, Salmonella typhi and Shigella flexneri) [70]. This property of CSN1S2 casein is detected when it goes through degradation by gastrointestinal enzyme pepsin [38]. The distinct antimicrobial impact of GM and its specific chemical composition can result in increased antimicrobial compounds production [71]. Another study shows that during the fermentation of GM with individual microorganisms of kefir grains, bioactive substances were released that have antimicrobial properties against deadly strains of bacteria present in food [72]. Short chain fatty acids (SCFA), Medium Chain Triglycerides (MCT), capric, caproic and caprylic acids found in GM have been proved to possesses antimicrobial activity [59]. GM proteins can be in-vitro hydrolysed by enzymes or can be fermented by lactic acid bacteria which give potent antioxidant peptides [73].
5.3 Treatment of cardiovascular disease (CVD)
CVD includes diseases that involves heart and blood vessels, veins, coronary heart diseases, high blood pressure, arrhythmias, atherosclerosis etc. Inorder to maintain normal blood pressure and proper heart functioning a good amount of potassium rich food is needed and GM serves for the same. GM supply 498.7 mg of K and 121.5 mg of Na that is sufficient in preventing high blood pressure and protecting against atherosclerosis. Atherosclerosis is likely to occur if people are adopting unhygienic inactive lifestyle (smoking, diet and exercise) and after incidence of dyslipidemia, diabetes, high blood pressure etc. [74]. The Angiotensin converting enzyme (ACE) inhibitory peptides obtained after hydrolysis of GM caseins have shown beneficial effects on blood pressure regulation [75]. Fat in GM reduces total cholesterol levels thereby making it as a food of choice for the prevention of cardiac disorders. GM have selenium and its absence is thought to cause irreversible cardiomyopathy [66]. When excess amount of fat is deposited in the arterial wall and blood vessels then cardiac arrest is common. In case of goat, fat present in its milk and meat is considered as user friendly [76]. The Low-density lipoprotein (LDL) is known as “bad cholesterol” as it transports cholesterol from liver to blood vessels while High-density lipoprotein is “good cholesterol” as it transports cholesterol from vessels to oxidative modification of LDL which suppresses atherosclerosis [74].
The composition of GM exceeds cow’s milk in monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and MCT which have beneficial health effects especially in cardiovascular conditions [23]. Due to anti-inflammatory effects of CLA GM decreases the atherosclerosis incidence [38]. The MCT present in GM includes capric, caproic and caprylic acids which comprises 15% of total milk fat. The higher constituent of MCT in GM helps in lowering cholesterol deposits in the arteries, dissolve and prevent cholesterol deposits in the gallstones. Also, the presence of MCT decrease the synthesis of endogenous cholesterol thus helping to boost the immune system [77]. Capric, caprylic acids and MCT are used in treatment of many diseases including cystic fibrosis, coronary by-pass etc, because of their unique ability to provide energy directly without being deposited in adipose tissues [78]. GM is naturally homogenised while cow’s milk requires homogeniser. When fat globules are forcibly broken down by mechanical homogeniser, an enzyme associated with milk fat i.e., xanthine oxidase become free and can penetrate intestinal wall. When it reaches blood stream via intestinal wall, it can cause tissue scar on the heart and arteries which leads to mechanism causing arteriosclerosis while it is prevented in case of GM [77].
5.4 Treatment of gastrointestinal diseases
Infants who are suffering from problems like gastrointestinal disturbances, vomiting, colic, constipation and diarrhoea can be treated when they are fed GM. Pasteurised GM is easily tolerated by infants who are suffering from such diseases. GM easily assimilates in human body as chemical composition of GM is almost similar to human one which therefore enhances the bioavailability of nutrients in it. It is reported that GM consumption increases the uptake of Iron and Copper in digestive tract [79]. The readily bioavailable nature of GM has increased its consumption in recent years. The availability of beneficial gut microbes increases when GM is taken. Soft curd formed in fermented milk of goat is easily digested and absorbed [22]. People who are lactose intolerance can also easily digest it because of its small sized fat globules in which the total surface area of globules are effectively connected with lipids and also the fat globules of GM do not clump together as in cow’s milk [29].
GM is the vital source of biorganic sodium, the absence of which causes arthritis. Human stomach stores more sodium than any other organ. The absence of sodium causes digestive discomforts and inhibits stomach from producing needed enzymes leading to bloating and even ulcers. Soft curd in GM can be advantageous for adult humans who are suffering from gastrointestinal disturbances and ulcers [5]. Also, the property of high buffering capacity of GM appears to be fruitful in treating gastric ulcers [52]. The intestinal inflammation and clinical symptoms (diarrhoea and bloody stools) in colitis can be decreased by consuming GM. The presence of oligosaccharides in its milk exhibits anti-inflammatory effect in the management of Inflammatory bowel disease (IBD) [43]. It has been reported in one study of rats infected with colitis when fed GM oligosaccharides reduces and promotes recovery of damaged colonic mucosa due to less severe lesions in colon and production of more favourable gut microbiota [38].
5.5 Treatment of cancer, allergy and others
Alpha lactalbumin present in GM is anti-carcinogenic by nature. CLA in GM is full of anti-carcinogenic properties. It is also studied that tumour cells in patients with skin and bladder cancers were killed by alpha lactalbumin. The passive transfer of serum albumin in GM to the blood has an inhibitory effect against growth and development of breast cancerous cells [75].
Proteins are most common antigens that are important for proper body functioning. On the basis of nature, allergies can be acute or chronic that have symptoms ranging from non-life threatening to life threatening. It is recommended as an substitute for patients with cow milk allergy [54]. Eczema, Rhinitis and digestive problems are simple symptoms while bronchospasm, anaphylaxis and urcaria are severe one. GM is less allergenic than cow’s milk. GM is thought to resolves 30–40% of problematic cases of childhood cow milk allergy. Some researches shows that alpha S1 casein in cow’s milk is the reason of cow milk intolerance. It has been found that level of alpha S1 casein in GM is 89% lower than that of cow milk. Therefore, GM is less allergic and improves digestive disorder, colic diseases etc. in people with cow milk sensitivities [80]. Lactose intolerance in many child and adults is caused by the deficiency of lactase enzyme that functions in easing the digestion of lactose. Generally, in case of lactose intolerant individuals, unhydrolyzed lactose passes into the large intestine whereby it is fermented by the aid of microbes which results in the production of hydrogen, methane, carbon-dioxide, SCFA leading to flatulence, diarrhoea as well as abdominal pain [81]. When ulcers worsen it takes a new form i.e., cancer and it is well known that the high buffering capacity of GM prevents gastric ulcers [52].
GM is used as a good alternative to treat mammary, colorectal and colon cancer [82] in case of animal models, as well as in vitro models of human melanoma [83] colorectal and breast cancer [84] because of the known anticarcinogenic properties of CLA [85] which is in surplus amount in it. Lactic Acid Bacteria (LAB) present in goat milk exhibit potential role in combating against cancer [86]. The risk of occurrence of cancer, carcinogenic toxicity and tumour suppression are prevented by LAB present in GM [87]. The bacteria in GM after isolation and microencapsulation can be used as a probiotics to cure cancer [88]. The study of different strains of LAB in GM can strengthen the research of cancer prevention [89].
5.6 Immunological properties
Se is vital as it plays role in proper functioning of the immune system and thyroid activity as well as participates in spermiogenesis thereby affecting fertility [90]. It is an integral part of the antioxidant capacity of the organism [91]. GM and its products act as immunity booster and prevents from several illness in infants [87]. There is involvement of many cells like T lymphocytes (T-cells), Natural Killer (NK) cells and B-lymphocytes (B-cells) in the innate and adaptive immune response. Even though the structure of Immunoglobulin’s (Ig) are similar, minor differences exist in the main immunological classes (IgG, IgM, IgA, IgD and IgE). The major properties of serum immunoglobulin accounts for IgG and IgA. Several researches have shown immunomodulatory effects of GM in case of both in-vitro and human studies. The release of nitric oxide (NO) from human blood cells exhibits cardio protective effects in the milk consumer and also possesses antibacterial activity which prevents them from infections. Content of sialic acid is higher in GM which acts as an important biological component in playing crucial role in brain development and in boosting infant immunity [92, 93].
6. Conclusion
Since GM is rich surplus to calcium, proteins, bioactive compounds it can be taken as a “functional and nutraceutical health drink”. The role played by GM in eliminating major health complications including digestive, respiratory, immunological, viral, cardiac, cancer, allergy, osteoporosis, malabsorption, anaemia etc. favours longevity to human life. The contribution of small developing nations in the production of GM should not be neglected rather new technological innovation’s assistance to those nations will uplift the production and contribute to mankind as the consumption of GM has increased in developed nations. The compositional attributes of GM can be raised if goats are provided with ample browsing, adequate temperature and stress-free environment. It should be supplemented with folic acid and can be fortified if consumers find its odour unpleasant.
Goat rearing has several economic returns after its milk, meat, hair etc. are marketed. Goat business can help uplifting the life standard of people in rural areas. The unique properties of GM and its products carve for its more marketing potential. Its nutritional value in treating diseases has broaden its future prospects. If grading up is followed to improve the performance of local breeds of different nations then eventually more milk can be produced that benefits human. That is why more thorough and detailed descriptive research in this field is needed to fight against life taking diseases.
\n',keywords:"arteriosclerosis, bioavailable, capra milk, fortification, immunity, substitute",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76625.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76625.xml",downloadPdfUrl:"/chapter/pdf-download/76625",previewPdfUrl:"/chapter/pdf-preview/76625",totalDownloads:133,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 18th 2021",dateReviewed:"April 7th 2021",datePrePublished:"December 2nd 2021",datePublished:null,dateFinished:"May 6th 2021",readingETA:"0",abstract:"Milk is clean lacteal secretion from mammalians shortly after parturition. GM is taken as a complete meal in human diet. GM is the only milk from milching species that possess possibility of substituting human milk. Availability of A2 casein in GM make it comparable to human milk in terms of protein. The most vulnerable ones are infants, aged people and pregnant women as their immune system could answer at any time if extra supplement is not administered. In this case, GM is only option that is highly compatible and nutritious nourishing food naturally. It has been used in curing respiratory problems, diarrhoea, colic, gastrointestinal disturbances etc. Feeding GM enhances production of immunoglobulin, beneficial gut microbiota, phagocytosis activities. Presence of inherent antibodies suits GM for using it in curing Tuberculosis. It contains every needed nutrient in higher amount as compared to milk from other animals. Per servings it has 13% more Calcium, 47% more vitamin A than Cow’s milk. It is filled with most of the trace minerals. Selenium, an immune system enhancer provides anti-oxidative and anti-inflammatory protection via inhibition of bacterial growth. Chlorine and Fluorine acts as natural germicides. GM contain good source of Potassium which is crucial for maintainance of blood pressure and functioning of heart, it protects against arteriosclerosis. GM not only reduces the level of total cholesterol due to presence of Medium Chain Triglycerides but also improve mineralisation of skeleton and haemoglobin level. GM consists huge source of biorganic sodium, the absence of which results in arthritis. People who are lactose intolerant even can consume GM as it has low lactose content and for those who finds its smell and taste unusual, there is option of fortification. Because of easily digestible and readily bioavailable nature its consumption has been increased.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76625",risUrl:"/chapter/ris/76625",signatures:"Rajendra Panta, Vinod Kumar Paswan, Pankaj Kumar Gupta and Dhruba Narayan Kohar",book:{id:"9706",type:"book",title:"Goat Science - Environment, Health and Economy",subtitle:null,fullTitle:"Goat Science - Environment, Health and Economy",slug:null,publishedDate:null,bookSignature:"Prof. Sándor Kukovics",coverURL:"https://cdn.intechopen.com/books/images_new/9706.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-78984-709-3",printIsbn:"978-1-78984-708-6",pdfIsbn:"978-1-78985-193-9",isAvailableForWebshopOrdering:!0,editors:[{id:"25894",title:"Prof.",name:"Sándor",middleName:null,surname:"Kukovics",slug:"sandor-kukovics",fullName:"Sándor Kukovics"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methodology",level:"1"},{id:"sec_3",title:"3. Composition of GM",level:"1"},{id:"sec_3_2",title:"3.1 Fat",level:"2"},{id:"sec_4_2",title:"3.2 Protein",level:"2"},{id:"sec_5_2",title:"3.3 Vitamin",level:"2"},{id:"sec_6_2",title:"3.4 Lactose",level:"2"},{id:"sec_7_2",title:"3.5 Minerals",level:"2"},{id:"sec_9",title:"4. Nutritional value in GM",level:"1"},{id:"sec_10",title:"5. GM medicinal value",level:"1"},{id:"sec_10_2",title:"5.1 Prevention of dengue fever",level:"2"},{id:"sec_11_2",title:"5.2 Antimicrobial properties",level:"2"},{id:"sec_12_2",title:"5.3 Treatment of cardiovascular disease (CVD)",level:"2"},{id:"sec_13_2",title:"5.4 Treatment of gastrointestinal diseases",level:"2"},{id:"sec_14_2",title:"5.5 Treatment of cancer, allergy and others",level:"2"},{id:"sec_15_2",title:"5.6 Immunological properties",level:"2"},{id:"sec_17",title:"6. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Haenlein, G.F.W., 2007. About the evolution of goat and sheep milk production. Small Rumin. Res. 68, 3-6'},{id:"B2",body:'Bagley MN (2006) Meat goat breeds, breeding management, and 4-H Market Goat Management. J Dairy Sci 28: 30-5'},{id:"B3",body:'Iqbal A., Khan B.B., Tariq M. and Mirza M.A. (2008). Goat-A Potential Dairy Animal: Present and Future Prospects. Pak. J. Agri. Sci., 45(2): 227-230'},{id:"B4",body:'FAOSTAT, 2013. Food and Agriculture Organization of the United Nations, Available at: http://faostat. fao.org (online, 18.9.2013)'},{id:"B5",body:'Haenlein G. F. W. (2004). Goat milk in human nutrition. Small Rumin. Res. 51: 154-163'},{id:"B6",body:'Haenlein, G. F. W. (2017): Why does goat milk matter? – A Review. Nutrition & Food Science International Journal 2(4): DOI: 10.19080/NFSIJ.2017.02.555594'},{id:"B7",body:'FAOSTAT (Food and Agriculture Organization of the United Nations). 2018. Statistics database. Accessed March. 26, 2021. http://www.fao.org/faostat/en/#data'},{id:"B8",body:'Devendra C, Liang JB. Conference summary of dairy goats in Asia: current status, multifunctional contribution to food security and potential improvements. J Small Rumin Res 2012; 108:1-11. https://doi.org/10.1016/j.smallrumres.2012.08.012'},{id:"B9",body:'National Dairy Development Board. 2015. [retrieved on: 30th March, 2021]'},{id:"B10",body:'Khan B. B., Iqbal A. and M. L. Mustafa (2003). Sheep and Goat Production. Department of Livestock Management. University of Agriculture, Faisalabad'},{id:"B11",body:'Pulina, G., Milan, M., Lavin, M., Theodoridis, A., Morin, E., Capote, J., & Thomas, D. (2018). Invited review: Current production trends, farm structures and economics of the dairy sheep and goat sectors. Journal Of Dairy Science, 101(8), 6715-6729. doi:10.3168'},{id:"B12",body:'Kris HK (2008) The history of domestication of goats. J Archaeolo Sci 28: 61-79'},{id:"B13",body:'Galal S (2005) Biodiversity in goats. Small Rumi Res 60: 75-81'},{id:"B14",body:'Park YW, Haenlein GFW (2006) Therapeutic and hypoallergenic values of goat milk and implication of food allergy. In. Y.W. Park and G.F.W. Haenlein. (eds): Handbook of Milk of Non bovine Mammals. Blackwell Publishing Professional, Oxford, England and Ames Iowa 121-36'},{id:"B15",body:'Raynal-Ljutovac, K., Gaborit, P., Lauret, A., 2005. The relationship between quality criteria of goat milk, its technological properties and the quality of the final products. Small Rumin. Res. 60, 167-177'},{id:"B16",body:'Adib A, Bertrand S (2009). Risk Analysis transfer pesticides to milk. Institute of Livestock. National Interprofessional Centre: 9'},{id:"B17",body:'Park, Y.W., Júarez, M., Ramos, M., Haenlein, G.F.W., 2007. Physicochemical characteristics of goat and sheep milk. Small Rumin. Res. 68, 88-113'},{id:"B18",body:'Pal, M. 2014. Goat milk and its potential in dairy industry. MSc Lecture Notes. Addis Ababa University, College of Veterinary Medicine, Debre Zeit, Ethiopia. Pp.1-11'},{id:"B19",body:'Masood MI, Qadir MI, Shirazi JH, Khan IU (2011) Beneficial effects of lactic acid bacteria on human beings. Crit Rev Microbiol 37: 91-98'},{id:"B20",body:'Zenebe T, Ahmed N, Kabeta T, Kebede G, Medicine V, et al. (2014) Review on Medicinal and Nutritional Values of Goat Milk. Academic Journal of Nutrition 3: 30-39'},{id:"B21",body:'Department of Agriculture, Forestry and Fisheries, Republic of South Africa (2016): https://www.nda.agric.za/doaDev/sideMenu/AgroProcessingSupport/docs/Goat%20Milk%20document%20 final.pdf'},{id:"B22",body:'Morgan D, Gunneberg C, Gunnell D, Healing TD, Lamerton S, et al. (2012) Medicinal properties of goat milk. J Dairy Goat 90: 1'},{id:"B23",body:'Nunez- Sanchez N, Martinez- Marin AL, Polvillo O, Fernandez-Cabanas VM, Carrizosa J, Urrutia B, Serradilla JM (2016) Near infrared spectroscopy (NIRS) for determination of milk fat fatty acid profile of goats. Food chem 190: 244-252'},{id:"B24",body:'Le Jaouen, J.C. The fabrication of farmstead goat cheese. Cheesemaker’s J. Ashfield MA 1987, 45-121'},{id:"B25",body:'Jandal, J.M., 1996. Comparative aspects of goat and sheep milk. Small Rumin. Res. 22, 177-185'},{id:"B26",body:'Ohiokpehai, O. 2003. Processed Food Products and Nutrient Composition of Goat Milk. Pakistan Journal of Nutrition 2 (2): 68-71, 2003'},{id:"B27",body:'Malau-Aduli BS, Eduvie IO, Lakpini CAM, Malau-Aduli, AEO (2001) Effects of supplementation on the milk yield of Red Sokoto does. Proceedings of the 26th Annual Conference of Nigerian Society for Animal Production, March 2001, ABU, Zaria, Nigeria, 353-6. 1'},{id:"B28",body:'Lima, M. J. R., Teixeira-Lemos E., Oliveira, J., Teixeira-Lemos L. P., Monteiro, A. M. C., Costa, J. M. (2018): Nutritional and Health Profile of Goat Products: Focus on Health Benefits of Goat Milk. 189-232. http://dx.doi.org/10.5772/intechopen.70321 In: Goat Science. Ed.: Kukovics, S. Print ISBN 978-1-78923- 202-8. Online ISBN 978-1-78923-203-5'},{id:"B29",body:'Lopez-Aliaga, I., J. DiazCastro, M.J.M. Alferez, M. Barrionuevo and M.S. Campos, 2010. A review of the nutritional and health aspects of goat milk in cases of intestinal resection. Dairy Science and Technology, 90: 611-622'},{id:"B30",body:'Jenness, R., 1980. Composition and characteristics of goat milk: Review 1968-1979. J. Dairy Sci., 63: 1605- 1630'},{id:"B31",body:'Ceballos, L.S., E.R. Morales, T. Dela, G. OrreAdarve, J.D. Castro, L.P. Martinez and M.R.S. Sampelayo, 2009. Composition of goat and cow milk produced under similar condition and analyzed by identical methodology. Journal of Food Composition and Analysis, 22: 322-329'},{id:"B32",body:'Slacanac, V., R. Bozanic, J. Hardi, J. Rezessyne, M. Lucan and V. Krstanovic, 2010. Nutritional and therapeutic value of fermented caprine milk. International Journal of Dairy Technology, 63: 171-189'},{id:"B33",body:'Belewu, M.A. and A.M. Adewole, 2009. Goat milk: A feasible dietary based approach to improve the nutrition of orphan and vulnerable children. Pakistan Journal of Nutrition, 8: 1711-1714'},{id:"B34",body:'Sarwar, G., H.G. Botting, T.A. Davis, P. Darling and P.B. Pencharz, 1998. Free amino acids in milks of human subjects, other primates and non primates. Br J. Nutr, 79: 129-131'},{id:"B35",body:'Tomotake H, Okuyama R, Katagiri M, Fuzita M, Yamato M, Ota F (2006) Comparsion between Holstein cow’s milk and Japanese-Saanen goat’s milk in fatty acid composition, lipid digestibility and protein profile. Biosci BiotechnolBiochem 70: 2771-2774'},{id:"B36",body:'Díaz-Castro, J., S. Hijano, M.J.M. Alférez, I. López-Aliaga and T. Nestares, 2010. Goat milk consumption protects DNA against damage induced by chronic iron overload in anaemic rats. Int Dairy, J. 20: 495-499'},{id:"B37",body:'Atanasova, J. and I. Ivanova, 2010. Antibacterial peptides from goat and sheep milk proteins. 70: Biotechnology and Biotechnol. Eq., 24: 1799-1803'},{id:"B38",body:'Park, Y., 2009. Bioactive components in goat milk. In Bioactive Components in Milk and Dairy Products, pp: 4381'},{id:"B39",body:'Conesa, C., L. Sanchez, C. Rota, M. Perez, M. and S. Farnoud, 2008. Isolation of lactoferrin from milk of different species; calorimetric and antimicrobial studies. Comp Biochem Physiol, 150: 131-139'},{id:"B40",body:'Bruhn CM, Schutz HG (1999) Consumer food safety knowledge and practices. J Food Safety 19: 73-87'},{id:"B41",body:'Juarez, M., M.C. Martin-Hernandez and M. Ramos, 2011. Biochemical characteristic of three types of goat cheese. Journal of Dairy Science, 75: 1747-1752'},{id:"B42",body:'Horackoval, S., P. Sedlackova1, M. Slukova and P. Milada, 2014. Influence of Whey, Whey Component and Malt on the Growth and Acids Production of Lactobacilli in Milk. Czech J. Food Sci., 32: 526-531'},{id:"B43",body:'Daddaoua, A., V. Puerta, P. Requena, A. Martinez Ferez, Zarzuelo, M.D. Suarez, J. Boza and O. MartinezAugustin, 2006. Goat milk oligosaccharides are anti-inflammatory in rats with hapten induced colitis. Journal of Nutrition, 136: 672-676'},{id:"B44",body:'Bosworth, A.W. and L.V. Slyke, 2009. Comparison of the composition of cow’s milk goat milk and human milk. cited from http://www.jbc.org/cgi/reprint. Cited on the 28th March, 2021'},{id:"B45",body:'Kunz, C., S. Rudloff, W. Baier, N. Klein and S. Strobel, 2000. Oligosaccharides in human milk: structural, functional and metabolic aspects. Annu Rev Nutr, 20: 699-722'},{id:"B46",body:'Silanikove, Leitner G, Merin U, Prosser C (2010) Recent advances in exploiting goat’s milk: Quality, safety and Production aspects. Small Ruminant Res 89: 110-124'},{id:"B47",body:'Haenlein GFW (2002) Composition of goat milk and factors affecting it. Small Rumi Res 51: 155-163'},{id:"B48",body:'Ednie AR, Harper JM, Bennett ES (2015) Sialic acids attached to N- and Oglycans within the Nav 1.4 D1S5–S6 linker contribute to channel gating. Biochim Biophys Acta1850 (2):307-317'},{id:"B49",body:'Geissler, C. and H. Powers, 2011. Human Nutrition London, UK: Churchill Livingstone, pp: 509-532'},{id:"B50",body:'Sharma R, Sanodiya BS, Thakur GS, Jaiswal P, Pal S, et al. (2013) Characterization of Lactic Acid Bacteria from Raw Milk Samples of Cow, Goat, Sheep, Camel and Buffalo with Special Elucidation to Lactic Acid Production. British Microbiol Res J 3: 743-752'},{id:"B51",body:'Walker, V., 1964. Therapeutic uses of goat milk in modern medicine. In: Proceedings of the International Conference on Goats. British Goat Society Publishers, London, UK, p. 53'},{id:"B52",body:'Park YW (1994) Hypo-allergenic and therapeutic significance of goat milk. Small Rumi Res 14: 151-161'},{id:"B53",body:'Tracey JB (2001) Goat’s milk for Infants. Health Options, Megazine'},{id:"B54",body:'Yangilar, F. (2013): As a potentially functional food: Goat’s milk and products. Journal of Food and Nutrition Research 1(4): 68-81'},{id:"B55",body:'Roy S. K. and Vadodaria V. P. (2006). Goat Milk and Its Importance. Indian Dairyman, 58 (3): 65-69'},{id:"B56",body:'Park YW (2006a) Goat milk—chemistry and nutrition. In: Park YW, Haenlein GFW (Eds), Handbook of Milk of Non-bovine Mammals. Blackwell Publishing Professional, Oxford, UK/Ames, Iowa, 34-58'},{id:"B57",body:'Businco, L., Bellanti, J., 1993. Food allergy in childhood. Hypersensitivity to cow’s milk allergens. Clin. Exp. Allergy 23, 481-483'},{id:"B58",body:'Lothe, L., Lindberg, T., Jacobson, I., 1982. Cow’s milk formula as a cause for infantile colic. Pediatrics 70, 7-10'},{id:"B59",body:'Van Immerseel, F., J. De Buck, F. Boyen, L. Bohez, F. Pasmans, J. Volf, M. Sevcik, I. Rychlick, F. Haesebrouck and R. Ductaelle, 2004. Medium chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enteric serovar enteritidis. Applied and Environmental Microbiology, 70: 3582-3587'},{id:"B60",body:'Huxtable, R.J.M., 1992. Physiological actions of taurine. Physiol Rev., 72: 101-163'},{id:"B61",body:'Krstanovic, V., V. Slacanac, R. Bozanic, J. Hardi, J. Rezessyne and M. Lucan, 2010. Nutritional and therapeutic value of fermented caprine milk. International Journal of Dairy Technology, 63: 171-189'},{id:"B62",body:'Lopez-Aliaga, I., M.J. Alferez, M.T. Nestares, P.B. Ros, M. Barrionuevo and M.S. Campos, 2005. Goat milk feeding causes an increase in biliary secretion of cholesterol and a decrease in plasma cholesterol levels in rats. J Dairy Sci., 88: 102-141'},{id:"B63",body:'Gubler DJ. Dengue Viruses. Encyclopedia of Virology. 2008: 5-14'},{id:"B64",body:'Guzman MG and Kouri G. Dengue. Lancet Infect Dis. 2002; 2(1): 33-42'},{id:"B65",body:'Rodriguez EM, Alaezos S, Romero DC. Chemometris studies of several minerals in milks. J. Agric. Food Chem. 1999; 47(4): 1520-24'},{id:"B66",body:'Morgan KC, Esteveg AO, Muller CL, Valadez BC, Vizuete AM, Szewczyk NJ et al. The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in caenorhabditids elegans. Toxicol. Sci. 2010; 118(2): 530- 543'},{id:"B67",body:'Goldenberg RL. The Plausibility of Micronutrient Deficiency in Relationship to Perinatal Infection. J. Nutr. 2003; 133(5): 1645S-1648S'},{id:"B68",body:'Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R et al. In vitro effect of selenium deficiency on west nile virus replication any cytopathogenicity. Virol. J. 2008; 5: 66'},{id:"B69",body:'Gupta C, Gupta UC and Subhas. Selenium deficiency in soils and crops and its impact on animal and human health. Curr Nutr Food Sci. 2010; 6(4): 268-80'},{id:"B70",body:'Triprisila , L. F., Suharjono, S., Christianto, A., & Fatchiyah, F. (2016). THE COMPARING OF ANTIMICROBIAL ACTIVITY OF CSN1S2 PROTEIN OF FRESH MILK AND YOGHURT GOAT BREED ETAWAH INHIBITED THE PATHOGENIC BACTERIA. Materia Socio-Media, 244-248. doi:10.5455/msm.2016.28.244-248'},{id:"B71",body:'Seifu, E., E.M. Buys, F. Donkine and I.M. Petzer, 2004. Antibacterial activity of the lactoperoxidase system against food-borne pathogens in Saanen and South African Indigenous goat milk. Food Control, 15: 447-452'},{id:"B72",body:'Biadata, A., Szablewski, T., Kurdys, M. L., & Radziejewska, R. C. (2020). Antimicrobial activity of goat\'s milk fermented by single strain of kefir grain microflora. European Food Research and Technology(246), 1231-1239'},{id:"B73",body:'Ahmed AS, El-Bassiony T, Elmalt LM, Ibrahim HR (2015) Identification of potent antioxidant bioactive peptides from goat milk proteins. Food Res Int 74: 80-88'},{id:"B74",body:'Lindqvist, H., 2008. Influence of herring (Clupeaharengus) intake on risk, Department of chemical and biological engineering. Göteborg: Chalmers University of Technology'},{id:"B75",body:'Nandhini, B., J. Angayarkanni and M. Palaniswam, 2012. Angiotensin converting enzyme inhibitory activity and antioxidant properties of goat milk hydrolysates. International Journal of Pharmacy and Pharmaceutical Sciences, 4: 367-370'},{id:"B76",body:'Addrizzo, D. R. (1998). Use of Goat Milk and Goat Meat as Therapeutic Aids in Cardiovascular Diseases. New York '},{id:"B77",body:'Alférez MJ, Barrionuevo M, López Aliaga I, Sanz-Sampelayo MR, Lisbona F, et al. (2001) Digestive utilization of goat and cow milk fat in malabsorption syndrome. J Dairy Res 68: 451-561'},{id:"B78",body:'Greenberger, N.J., Skillman, T.G., 1969. Medium chain triglycerides. Physiologic considerations and clinical implications. New Engl. J. Med. 280, 1045-1058'},{id:"B79",body:'Gajewska, R., Ganowiak, Z., Nabrzyski, M., 1997. Nutrient and mineral composition of goat milk products. Roczniki Panstwowego Zakadu Higieny 48, 409-414'},{id:"B80",body:'McCullough, F. 2003. Nutritional evaluation of goat\'s milk. Health Food J., 105: 239-251'},{id:"B81",body:'Russel, D., R. Ross, G. Fitzgerald and C. Stanton, 2011. Metabolic activities and probiotic potential of Bifidobacteria. International Journal of Food Microbiology, 149: 88-105'},{id:"B82",body:'Herich R, Levkut M (2002) Lactic acid bacteria, probiotics and immune system. Veterinarni Medicina 47: 169-180'},{id:"B83",body:'Shultz, T.D., B.P. Chew, W.R. Seaman and L.O. Luedecke, 1992. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in-vitro growth of human cancer cells. Cancer Lett., 63: 125-133'},{id:"B84",body:'Durgam, V.R. and G. Fernandes, 2000. The growth inhibitory effect of conjugated linoleic acid on MCF7 Dietary fatty acids and human health. Animal Research, 49: 165'},{id:"B85",body:'Jirillo, F., G.D. Martemucci, A.G. Alessandro, M.A. Panaro, A. Cianciulli, M. Superbo and T. Magrone, 2010. Ability of goat milk to modulate healthy human peripheral blood lymphomonocyte and polymorpho nuclear cell function: In vitro effects and clinical implications. Curr. Pharmaceutical Design, 16: 870-876'},{id:"B86",body:'Kumar KS, Sastry N, Polaki H, Mishra V (2015) Colon Cancer Prevention through Probiotics: An Overview. J Cancer Sci Ther 7: 81-92'},{id:"B87",body:'Chauhan A, Bharti M (2013) Lactic Acid Bacteria and Its Use in Probiotics. J Bioremed Biodeg 4:8'},{id:"B88",body:'Villa-Garcia M, Pedroza-Islas R, Moreno R, De la Rosa M, Martinez Ferez A (2014) Suitability of goat milk fractions for microencapsulation of probiotics microorganisms. Immunol Let 9: 2-5'},{id:"B89",body:'Mittu, B., & Girdhar, Y. (2015). Role of Lactic Acid Bacteria Isolated from Goat Milk in Cancer Prevention. Autoimmune and Infectious Diseases: Open Access, 1.2(ISSN 2470-1025). doi:10.16966/2470-1025.108'},{id:"B90",body:'Skalickova, S., Milosavljevic, V., Chialova, K., Horky, P., Richtera, L. and Adam, V. 2017. Perspectives of selenium nanoparticles as a nutrition supplement. Nutrition, 33: 83-90'},{id:"B91",body:'Klusonova, I., Horky, P., Skladanka, J., Kominkova, M., Hynek, D., Zitka, O., Skarpa, P., Kizek, R. and Adam, V. 2015. An Effects of Various Selenium Forms and Doses on Antioxidant Pathways at Clover (Trifolium pratense L.). Int. J. Electrochem. Sci., 10(12): 9975-9987'},{id:"B92",body:'EdnieAR, Harper JM, Bennett ES (2015) Sialic acids attached to N- and Oglycans within the Nav 1.4 D1S5–S6 linker contribute to channel gating.Biochim Biophys Acta 1850 (2):307-317'},{id:"B93",body:'Formiga de Sousa YR, Vasconcelas MAS, Costa RG, Filho CAA, Paiva EPP, Queiroga RCRE (2015) Sialic acid content of goat milk during lactation.Livest Sci 177: 175-180'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Rajendra Panta",address:"rajendrapanta3@gmail.com",affiliation:'
Department of Dairy Science and Food Technology, Banaras Hindu University, India
Shree Jay Kalika Secondary School Technical and Vocational Training, Nepal
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If left untreated, excess catecholamines may result in hypertensive crisis leading to cardiac complications, cerebrovascular stroke, or ultimately sudden death. These catecholamine-secreting tumors are most commonly sporadic, but about 30% of patients have this disease as part of a familial disorder such as multiple endocrine neoplasia type 2 (MEN2) or von Hippel-Lindau (VHL) syndrome. Although most are benign, accurate recognition of pheochromocytomas with malignant potential and distant metastases remains a major diagnostic challenge. Advances in the field of molecular genetics have led to novel diagnostic and therapeutic strategies in an attempt to address this dilemma. Surgical excision of pheochromocytomas and paragangliomas is the mainstay of treatment and offers the only potential for cure. This chapter focuses on recent developments in the diagnosis of pheochromocytomas, encompassing biochemical, radiologic, histologic, and molecular analyzes. 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Blondel",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"62085",title:"Dr.",name:"Jacek",surname:"Mackiewicz",slug:"jacek-mackiewicz",fullName:"Jacek Mackiewicz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding-funders-list",title:"List of Funders by Country",intro:"
If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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Shaheer Akhtar and Hyung-Shik Shin",coverURL:"https://cdn.intechopen.com/books/images_new/10281.jpg",editedByType:"Edited by",editors:[{id:"52613",title:"Dr.",name:"Sadia",middleName:null,surname:"Ameen",slug:"sadia-ameen",fullName:"Sadia Ameen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9913",title:"Carbon Nanotubes",subtitle:"Redefining the World of Electronics",isOpenForSubmission:!1,hash:"43a22b8570e841b7a26d70159b2f755d",slug:"carbon-nanotubes-redefining-the-world-of-electronics",bookSignature:"Prasanta Kumar Ghosh, Kunal Datta and Arti Dinkarrao Rushi",coverURL:"https://cdn.intechopen.com/books/images_new/9913.jpg",editedByType:"Edited by",editors:[{id:"294687",title:"Dr.",name:"Prasanta",middleName:"Kumar",surname:"Ghosh",slug:"prasanta-ghosh",fullName:"Prasanta Ghosh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10479",title:"21st Century Advanced Carbon Materials for Engineering Applications",subtitle:"A Comprehensive Handbook",isOpenForSubmission:!1,hash:"712d04d43dbe1dca7dec9fcc08bc8852",slug:"21st-century-advanced-carbon-materials-for-engineering-applications-a-comprehensive-handbook",bookSignature:"Mujtaba Ikram and Asghari Maqsood",coverURL:"https://cdn.intechopen.com/books/images_new/10479.jpg",editedByType:"Edited by",editors:[{id:"286820",title:"Dr.",name:"Mujtaba",middleName:null,surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10411",title:"Materials at the Nanoscale",subtitle:null,isOpenForSubmission:!1,hash:"be29908600b7067c583ac21da1544a2d",slug:"materials-at-the-nanoscale",bookSignature:"Awadesh Kumar Mallik",coverURL:"https://cdn.intechopen.com/books/images_new/10411.jpg",editedByType:"Edited by",editors:[{id:"178218",title:"Dr.",name:"Awadesh",middleName:null,surname:"Mallik",slug:"awadesh-mallik",fullName:"Awadesh Mallik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10465",title:"Silver Micro-Nanoparticles",subtitle:"Properties, Synthesis, Characterization, and Applications",isOpenForSubmission:!1,hash:"dcc19a2b44c91940e16d82fd5eb8fffa",slug:"silver-micro-nanoparticles-properties-synthesis-characterization-and-applications",bookSignature:"Samir Kumar, Prabhat Kumar and Chandra Shakher Pathak",coverURL:"https://cdn.intechopen.com/books/images_new/10465.jpg",editedByType:"Edited by",editors:[{id:"296661",title:"Dr.",name:"Samir",middleName:null,surname:"Kumar",slug:"samir-kumar",fullName:"Samir Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10469",title:"Nanofibers",subtitle:"Synthesis, Properties and Applications",isOpenForSubmission:!1,hash:"28dc655dde01b94399cab954663f8bff",slug:"nanofibers-synthesis-properties-and-applications",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10469.jpg",editedByType:"Edited by",editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10505",title:"Colloids",subtitle:"Types, Preparation and Applications",isOpenForSubmission:!1,hash:"55025219ea1a8b915ec8aa4b9f497a8d",slug:"colloids-types-preparation-and-applications",bookSignature:"Mohamed Nageeb Rashed",coverURL:"https://cdn.intechopen.com/books/images_new/10505.jpg",editedByType:"Edited by",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:99,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"50566",doi:"10.5772/63234",title:"Influences of Doping on Photocatalytic Properties of TiO2 Photocatalyst",slug:"influences-of-doping-on-photocatalytic-properties-of-tio2-photocatalyst",totalDownloads:5353,totalCrossrefCites:23,totalDimensionsCites:75,abstract:"As a kind of highly effective, low‐cost, and stable photocatalysts, TiO2 has received substantial public and scientific attention. However, it can only be activated under ultraviolet light irradiation due to its wide bandgap, high recombination, and weak separation efficiency of carriers. Doping is an effective method to extend the light absorption to the visible light region. In this chapter, we will address the importance of doping, different doping modes, preparation method, and photocatalytic mechanism in TiO2 photocatalysts. Thereafter, we will concentrate on Ti3+ self‐doping, nonmetal doping, metal doping, and codoping. Examples of progress can be given for each one of these four doping modes. The influencing factors of preparation method and doping modes on photocatalytic performance (spectrum response, carrier transport, interfacial electron transfer reaction, surface active sites, etc.) are summed up. The main objective is to study the photocatalytic processes, to elucidate the mechanistic models for a better understanding the photocatalytic reactions, and to find a method of enhancing photocatalytic activities.",book:{id:"5139",slug:"semiconductor-photocatalysis-materials-mechanisms-and-applications",title:"Semiconductor Photocatalysis",fullTitle:"Semiconductor Photocatalysis - Materials, Mechanisms and Applications"},signatures:"Fei Huang, Aihua Yan and Hui Zhao",authors:[{id:"178389",title:"Dr.",name:"Fei",middleName:null,surname:"Huang",slug:"fei-huang",fullName:"Fei Huang"},{id:"185126",title:"Dr.",name:"Aihua",middleName:null,surname:"Yan",slug:"aihua-yan",fullName:"Aihua Yan"},{id:"185127",title:"Ms.",name:"Hui",middleName:null,surname:"Zhao",slug:"hui-zhao",fullName:"Hui Zhao"}]},{id:"17184",doi:"10.5772/17039",title:"Polymer Nanocomposites: From Synthesis to Applications",slug:"polymer-nanocomposites-from-synthesis-to-applications",totalDownloads:17288,totalCrossrefCites:31,totalDimensionsCites:68,abstract:null,book:{id:"1045",slug:"nanocomposites-and-polymers-with-analytical-methods",title:"Nanocomposites and Polymers with Analytical Methods",fullTitle:"Nanocomposites and Polymers with Analytical Methods"},signatures:"S. Anandhan and S. Bandyopadhyay",authors:[{id:"27050",title:"Prof.",name:"Sri",middleName:null,surname:"Bandyopadhyay",slug:"sri-bandyopadhyay",fullName:"Sri Bandyopadhyay"},{id:"44992",title:"Prof.",name:"Anandhan",middleName:null,surname:"Srinivasan",slug:"anandhan-srinivasan",fullName:"Anandhan Srinivasan"}]},{id:"9725",doi:"10.5772/8508",title:"Biosynthesis and Application of Silver and Gold Nanoparticles",slug:"biosynthesis-and-application-of-silver-and-gold-nanoparticles",totalDownloads:27927,totalCrossrefCites:23,totalDimensionsCites:58,abstract:null,book:{id:"3621",slug:"silver-nanoparticles",title:"Silver Nanoparticles",fullTitle:"Silver Nanoparticles"},signatures:"Zygmunt Sadowski",authors:null},{id:"17194",doi:"10.5772/21694",title:"Properties of Nanofillers in Polymer",slug:"properties-of-nanofillers-in-polymer",totalDownloads:20385,totalCrossrefCites:9,totalDimensionsCites:56,abstract:null,book:{id:"1045",slug:"nanocomposites-and-polymers-with-analytical-methods",title:"Nanocomposites and Polymers with Analytical Methods",fullTitle:"Nanocomposites and Polymers with Analytical Methods"},signatures:"Damien M. Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5365,totalCrossrefCites:23,totalDimensionsCites:55,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:74,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:123,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:211,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:49,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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