Reader with dyslexia [17].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6076",leadTitle:null,fullTitle:"Soil pH for Nutrient Availability and Crop Performance",title:"Soil pH for Nutrient Availability and Crop Performance",subtitle:null,reviewType:"peer-reviewed",abstract:"This book offers effective methods of regulating soil pH for sustainable crop production by decreasing soil contaminants, balancing soil pH, improving nutrient uptake, and increasing crop yields. The book discusses methods of measuring soil pH, factors influencing soil pH, the influence of soil pH on nutrient availability and microbial activity, the causes and amendments of soil acidity, the effects of fertilizers on soil acidity, and soil pH preferences of various crops. This book will serve as a guide for understanding the roles of pH in soil and crop productivities. This is an important resource for soil, crop, and environmental scientists, agronomists, crop physiologists, botanists, foresters, wildlife scientists, and students in these disciplines.",isbn:"978-1-78985-016-1",printIsbn:"978-1-78985-015-4",pdfIsbn:"978-1-83881-277-5",doi:"10.5772/68057",price:100,priceEur:109,priceUsd:129,slug:"soil-ph-for-nutrient-availability-and-crop-performance",numberOfPages:82,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"173305a5e0ae12b94fd56c04957acbdd",bookSignature:"Suarau Oshunsanya",publishedDate:"January 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6076.jpg",numberOfDownloads:6189,numberOfWosCitations:9,numberOfCrossrefCitations:10,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:18,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:37,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 7th 2017",dateEndSecondStepPublish:"July 28th 2017",dateEndThirdStepPublish:"October 24th 2017",dateEndFourthStepPublish:"January 22nd 2018",dateEndFifthStepPublish:"March 23rd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya",profilePictureURL:"https://mts.intechopen.com/storage/users/175778/images/8206_n.jpg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Ibadan",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"675",title:"Soil Chemistry",slug:"soil-chemistry"}],chapters:[{id:"64810",title:"Introductory Chapter: Relevance of Soil pH to Agriculture",doi:"10.5772/intechopen.82551",slug:"introductory-chapter-relevance-of-soil-ph-to-agriculture",totalDownloads:1933,totalCrossrefCites:4,totalDimensionsCites:9,hasAltmetrics:0,abstract:null,signatures:"Suarau Odutola Oshunsanya",downloadPdfUrl:"/chapter/pdf-download/64810",previewPdfUrl:"/chapter/pdf-preview/64810",authors:[{id:"175778",title:"Dr.",name:"Suarau",surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"}],corrections:null},{id:"57209",title:"Effects of Acid Soils on Plant Growth and Successful Revegetation in the Case of Mine Site",doi:"10.5772/intechopen.70928",slug:"effects-of-acid-soils-on-plant-growth-and-successful-revegetation-in-the-case-of-mine-site",totalDownloads:1793,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Acid soils are caused by mining, potentially causing the death of plants. Although soil pH is one of the useful indicators to evaluate acid soil conditions for successful revegetation, the dissolution of harmful elements under acidic conditions should be considered in addition to the tolerance mechanism of plants in mines. Thus, this study aims to report the current situation of acid soils and plant growth in mine site and to elucidate the effects of acid soils on plant growth over time through field investigation and a vegetation test. The results showed that the dissolution of Al from acid soils which were attributed to the dissolution of sulfides influenced plant growth. Not only soil pH but also the assessment of the dissolution of sulfides over time is crucial for successful revegetation, suggesting that net acid producing potential (NAPP) and net acid generation (NAG) pH, which are used for evaluating the formation of acidic water, are useful to evaluate soil conditions for the revegetation. Furthermore, acid-tolerant plant survived under acidic conditions by increasing the resistance against acidic conditions with the plant growth. Such factors and the proper selection of plant species play an important role in achieving successful revegetation in mines.",signatures:"Shinji Matsumoto, Hideki Shimada, Takashi Sasaoka, Ikuo Miyajima,\nGinting J. Kusuma and Rudy S. Gautama",downloadPdfUrl:"/chapter/pdf-download/57209",previewPdfUrl:"/chapter/pdf-preview/57209",authors:[null],corrections:null},{id:"59663",title:"Fluoride Adsorption onto Soil Adsorbents: The Role of pH and Other Solution Parameters",doi:"10.5772/intechopen.74652",slug:"fluoride-adsorption-onto-soil-adsorbents-the-role-of-ph-and-other-solution-parameters",totalDownloads:1303,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Soil adsorbents continue to attract increasingly high numbers of researchers in water defluoridation studies. An aspect of solution parameters, that is the aqueous adsorption of fluoride onto soil adsorbents in defluoridation studies, has been reviewed and reported. The pH was found to be the main factor controlling fluoride adsorption on the popular soil adsorbents including: aluminosilicates, iron (hydr)oxides, aluminum (hydr)oxides, apatites, carbonaceous minerals, calcareous soils and zeolites and the other key parameters being temperature, time of contact, and co-existent ions. Fluoride adsorption onto metal-exchanged zeolites and hydroxyapatites (optimum pH = 4–10), iron (hydro)oxide minerals (pH = 2–7), and carbonaceous minerals (pH = 4–12) is relatively pH-independent, and high amounts of fluoride are able to sorb upon the surfaces of these minerals in a wide range of pH values. However, montmorillonites (optimum pH = 5–6), aluminum (hydro)oxide minerals (pH = 5–7), and calcareous minerals (pH = 5–6) only sorb significant amount of fluoride in a narrow range of pH values. The fluoride adsorption onto the latter class of minerals, also generally occurring at slightly above room temperatures, appears to be highly specific and not strongly affected by the presence of coexistent anions including: PO43−,SO42−,Cl−,andNO3−.",signatures:"Enos Wamalwa Wambu and Audre Jerop Kurui",downloadPdfUrl:"/chapter/pdf-download/59663",previewPdfUrl:"/chapter/pdf-preview/59663",authors:[null],corrections:null},{id:"60653",title:"Control of Soil pH, Its Ecological and Agronomic Assessment in an Agroecosystem",doi:"10.5772/intechopen.75764",slug:"control-of-soil-ph-its-ecological-and-agronomic-assessment-in-an-agroecosystem",totalDownloads:1162,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Lithuania is located in the humid zone, where mean annual precipitation exceeds mean evapotranspiration and soil acidification is an ongoing natural process encouraged by anthropogenic activities. Traditionally, the process may be controlled by different intensity liming. The chapter summarizes the data on long-term liming and fertilization experiments made in Western Lithuania. The object of the investigation is the naturally acid soil, Bathygleyic Dystric Glossic Retisol (texture: moraine loam with clay-sized particles content of 12–14%), and the same soil exposed for more than half a century to different liming and fertilization intensity. Our systematic analysis shows that it is impossible to reach appropriate moraine loam soil conditions for organic matter decomposition, carbon sequestration, soil aggregation, nitrogen fixation, nutrient accumulation, and plant growth by using intensive liming only. It is necessary to co-ordinate proper liming and organic fertilizing. The soil acidity was neutralized (pHKCl 5.9 ± 0.1) and mobile aluminum abolished in the topsoil and subsoil to a 60 cm depth; moreover, the highest amount of soil organic carbon (1.91%), water stable aggregates (59%), intense nitrogen fixation, and highest grain yield was established in the periodically limed (with 1.0 rate CaCO3 every 7 years) soil with 60 t ha−1 farmyard manure (FYM) application.",signatures:"Danute Karcauskiene, Regina Repsiene, Dalia Ambrazaitiene,\nRegina Skuodiene and Ieva Jokubauskaite",downloadPdfUrl:"/chapter/pdf-download/60653",previewPdfUrl:"/chapter/pdf-preview/60653",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"8123",title:"Metals in Soil",subtitle:"Contamination and Remediation",isOpenForSubmission:!1,hash:"5bf06fb97dff16934a2319d873089ec6",slug:"metals-in-soil-contamination-and-remediation",bookSignature:"Zinnat Ara Begum, Ismail M. 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Leen",slug:"gabriel-leen",email:"Gabriel.Leen@ul.ie",position:null,institution:null},{id:"269579",title:"M.Sc.",name:"Fintan",middleName:null,surname:"McGuinness",fullName:"Fintan McGuinness",slug:"fintan-mcguinness",email:"Fintan.McGuinness@ul.ie",position:null,institution:null},{id:"269580",title:"Dr.",name:"Gerard",middleName:null,surname:"Dooly",fullName:"Gerard Dooly",slug:"gerard-dooly",email:"Gerard.Dooly@ul.ie",position:null,institution:null}]},book:{id:"8271",title:"Applications of Optical Fibers for Sensing",subtitle:null,fullTitle:"Applications of Optical Fibers for Sensing",slug:"applications-of-optical-fibers-for-sensing",publishedDate:"April 24th 2019",bookSignature:"Christian Cuadrado-Laborde",coverURL:"https://cdn.intechopen.com/books/images_new/8271.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"220902",title:"Dr.",name:"Christian",middleName:null,surname:"Cuadrado-Laborde",slug:"christian-cuadrado-laborde",fullName:"Christian 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The high-frequency properties (permittivity or permeability) of these materials strongly depend on structure, composition, shape, and orientation. Therefore, this book intends to present readers with advances not only in materials science (including metamaterials), but also in measurements and novel functional applications that demand the special properties of electromagnetic materials.",isbn:"978-1-83880-101-4",printIsbn:"978-1-78985-226-4",pdfIsbn:"978-1-83880-102-1",doi:"10.5772/intechopen.79786",price:139,priceEur:155,priceUsd:179,slug:"electromagnetic-materials-and-devices",numberOfPages:362,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"0cc0489a203ae888b1105719a4e70ecd",bookSignature:"Man-Gui Han",publishedDate:"January 22nd 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8653.jpg",keywords:null,numberOfDownloads:14444,numberOfWosCitations:10,numberOfCrossrefCitations:10,numberOfDimensionsCitations:31,numberOfTotalCitations:51,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 4th 2018",dateEndSecondStepPublish:"September 3rd 2018",dateEndThirdStepPublish:"November 2nd 2018",dateEndFourthStepPublish:"January 21st 2019",dateEndFifthStepPublish:"March 22nd 2019",remainingDaysToSecondStep:"4 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"250649",title:"Prof.",name:"Man-Gui",middleName:null,surname:"Han",slug:"man-gui-han",fullName:"Man-Gui Han",profilePictureURL:"https://mts.intechopen.com/storage/users/250649/images/system/250649.jpeg",biography:"Dr. Man-Gui Han obtained his PhD degree in Materials Science and Engineering from Iowa State University (USA) in 2004. Currently, he is a professor in the University of Electronic Science and Technology of China. He is also one of the journal editors of IEEE Transaction on Magnetics starting from 2012. Up to now, he has published more than 70 peer-reviewed journals papers in the fields of magnetic materials with especial interests in the high frequency properties and applications of magnetic materials. One of his research interests is to employ the Mössbauer spectroscopy to study magnetic materials. He has established his academic reputation by finding a giant magnetostrictive effect in Gd5(Si0.5Ge0.5)4, developing electromagnetic wave absorption materials, and the realisation of negative imaginary parts of high frequency permeability by spin transfer torque effect. He has given several invited talks in the international conferences in Germany, Russia, United Kingdoms and China.",institutionString:"University of Electronic Science and Technology of China",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Electronic Science and Technology of China",institutionURL:null,country:{name:"China"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"940",title:"Electromagnetism",slug:"metals-and-nonmetals-electromagnetism"}],chapters:[{id:"65188",title:"Dielectric Losses of Microwave Ceramics Based on Crystal Structure",slug:"dielectric-losses-of-microwave-ceramics-based-on-crystal-structure",totalDownloads:915,totalCrossrefCites:2,authors:[{id:"244302",title:"Prof.",name:"Hitoshi",surname:"Ohsato",slug:"hitoshi-ohsato",fullName:"Hitoshi 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Over time, more and more people have become aware of these differences due to the brain research (1930–1960) that became the foundation of the field of learning disabilities.The terms such as brain-injured child was first used by Alfred Strauss and Laura Lehtinen. Although many researchers have contributed to the field, the seminal works of two important scientists are phenomenal even today. Adolf Kussmaul (1877), a German neurologist was the first to identify reading disability and coined the term “word blindness.” He defines it as “complete text blindness … although the power of sight, the intellect, and the powers of speech are intact.” Almost after 10 years after the term “word blindness” appeared, the term ‘dyslexia’ was used by Berlin (1887) to define reading challenges [1, 2].
The other influential researcher, who has made great contributions to the Learning Disability (LD) construct and develops understanding of the various issues related to LD was Pringle Morgan in the united Kingdom. The article by Pringle Morgan entitled “A Case of Congenital Word Blindness” (Morgan, 1896) in the British Medical Journal encouraged researchers and formed a basis for research to study other cases of LD to further explore studies on the definitions and identification tools of LD. Samuel A. Kirk was the first Psychologist to use the term “learning disability” in the year 1963 in Chicago at an education conference. ADHD first appeared in 1968 in the Diagnostic and Statistical Manual (DSM) as “hyperkinetic impulse disorder.” Ever since 2000, awareness and research of learning disabilities and ADHD issues has taken off and in the year 2013 DSM-5 broadened its definition of the term “specific learning disorder” [1, 2].
Learning disability is referred to as a hidden disability as children with learning disabilities do not look handicapped and their difficulties are not obvious. Hence, learning disabled children are often misunderstood and accused of not listening, being lazy or clumsy resulting in low self-esteem, confidence and motivation. So we can consider the child to be suffering with learning disability when he/she displays an educationally significant discrepancy between his/her estimated intellectual potential and actual school performance that cannot be explained in terms of intellectual potential. These children may have a combination of difficulties in speaking, listening, reading, comprehension, spelling, arithmetic calculations, writing and concepts. Children with a learning disability have average and sometimes above average intelligence.
LD is a neurodevelopmental disorder that are not due to hearing or vision problems, social-economic factors, cultural or linguistic differences, lack of motivation, insufficient or unsatisfactory instruction. It is due to the interaction of genetic, epigenetic, and environmental factors with a biological origin that affects the brain’s ability to perceive and/or process verbal and non-verbal information efficiently and accurately.
Learning disabilities are multifaceted and go beyond the stereotypical perceptions of the disorder as simply reading difficulties, or letter problems. They differ significantly, both in terms of the meanings they impact and the rigorousness of the impact experienced. The proper accommodations depend upon the individual’s strengths as well as his/her detailed difficult situations [3].
SLD is a clinical condition which is not always synonymous with “learning disabilities” as defined by the educational system: not all children with learning c deficits diagnosed by the school system would fit the definition for a DSM-5 clinical diagnosis of SLD [4].
Learning disabilities (LDs) are diagnosed using both educational and medical perspectives [5]. The most commonly used definition from an educational perspective, is found in the federal special education law, the Individuals with Disabilities Education Act (IDEA). Diagnostic and Statistical Manual for Mental Disorders (currently the DSM-5 and previously the DSM-IV) published by the American Psychiatric Association defines LD from the medical perspective [6]. A considerable overlap in the definition of LD used by professionals in educational and medical settings can be observed [5].
A specific learning disability is defined by the Individuals with Disabilities Education Act (IDEA) as a disorder in one or more of the basic psychological processes involved in understanding or using language, whether spoken or written, that manifests itself in the inability to listen, think, speak, read, write, spell, or perform mathematical calculations. Perceptual impairments, brain damage, mild brain dysfunction, dyslexia, and developing aphasia are all included in this category. It clearly establishes that specific learning disabilities are not primarily the result of visual, hearing, motor disabilities, mental retardation, emotional disturbance, or of environmental, cultural, or economic disadvantage [7].
SLD is a form of Neurodevelopmental Disorder, according to the DSM-5, that inhibits the ability to learn or apply specific academic abilities (e.g., reading, writing, or arithmetic), which are the foundations for all other academic learning. Difficulties in learning are “unexpected,” although the rest of the child’s development appears to be normal. Though early indicators of learning impairments (such as trouble learning letters or counting items) may occur in preschool, they can only be diagnosed reliably after formal education begins. The way the SLD manifests clearly implies that it typically persists into adulthood and is understood to be a cross-cultural and chronic condition albeit with cultural differences and developmental changes in children [8].
According to DSM-5, the diagnosis of a specific learning disorder includes the following symptoms:
During formal years at school, persistent difficulties in reading, writing, arithmetic, or mathematical reasoning skills can be identified by symptoms such as inaccurate or slow and effortful reading, poor written expression, difficulties remembering number facts, or inaccurate mathematical reasoning.
Current academic abilities must fall far short of the typical range of scores on linguistically and culturally relevant reading, writing, and arithmetic examinations. As a result, a dyslexic person must read with significant effort and not in the same way that a regular reader does.
Learning problems originate in the early years of schooling.
The individual’s difficulties must markedly impair academic success, occupational performance, or daily activities, and they must not be explained by developmental, neurological, sensory (vision or hearing), or motor disorders [6].
In both basic research and clinical practice, categorical classification schemes are applied to select groups of children for further study or clinical intervention. DSM does not limit the diagnosis to reading, math, or written expression but more generally describes problems in achieved academic skills with the potential for specification of the more traditional areas by taking a different approach to LDs by broadening the category into a single overall diagnosis [6]. Diagnosis of SLD according to DSM-V is made based on a clinical review of an individual’s history, teacher reports and academic records, and responses to interventions. To categorize the child in LD group, difficulties must be persistent, scores must be well below the range on appropriate measures, and the problems could not be better explained by other disorders. The interference in achievement, occupation, or activities of daily living must be significantly present [9].
Learning difficulties are classified at multiple levels, including categorizing children as LD, usually achieving, or mentally inferior, and within LD, as reading versus math impaired. LD is distinguished from types of low achievement that are expected due to emotional disturbance, social or cultural disadvantage, or inadequate instruction, and is identified as a particular type of “unexpected” low achievement across classes of presumed childhood conditions that produce underachievement [10].
LD is rarely conceptualized as a single disability in any federal or non-federal classification; rather, it is represented as a broad category that includes difficulties in any one or a combination of academic disciplines. The federal definition of 1968 specifies seven domains: (1) listening; (2) speaking; (3) basic reading (decoding and word recognition); (4) reading comprehension; (5) arithmetic calculation; (6) mathematics reasoning; and (7) written expression. The inclusion of these seven aspects of impairment in the federal classification assures that the LD category encompasses a wide range of learning issues and that the very diverse learning problems should be grouped together. Even today, many studies simply label groups of students as “learning disabled,” despite mounting evidence that LD correlates with poor reading, math, and other subjects [9].
Many mental health professionals, including the Learning Impairments Association of America, consider the seven disorders listed below to be unique learning disabilities. They identify Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) as related but distinct learning disorders that impact learning [6].
Dyslexia
Dysgraphia
Dyscalculia
Auditory processing disorder
Language processing disorder
Nonverbal learning disabilities
Visual perceptual/visual motor deficit
Dyslexia (also known as reading disability) a specific learning disability that affects reading and related language-based processing skills is the most common learning disability accounting for at least 80 per cent of all LDs. It can affect reading fluency; decoding, reading comprehension, recall, writing, spelling, and sometimes speech and can exist along with other related disorders. However, the severity can differ in each individual and dyslexia sometimes is referred to as a Language-Based Learning Disability.
The word “dyslexia” is of Greek origin, meaning “impaired”. Lyon et.al (2003) defined dyslexia as a SLD that is neurobiological in origin and characterized by difficulties with inaccurate word recognition and poor spelling and decoding abilities. These difficulties typically result from a deficit in the phonological component of language” [10].
Reading impairments are thought to be caused by phonological processing problems, according to study (i.e., processing the sounds of speech). Individuals with reading impairments frequently struggle to decode words into separate sounds and/or blend sounds together in order to read words fast and properly. These decoding issues frequently lead to reading comprehension issues [10]. During reading, Magnetic resonance imaging (fMRI) reveals a different brain activation profile confirming the etiology of Dyslexia to be neurological and genetic causes. The left side of the brain is activated by three systems: an anterior system in the left inferior frontal region that affects phoneme production (articulating words silently or out loud), a left parietotemporal system that analyses the written word, and a left occipitotemporal system that performs automatic word recognition. Dyslexic youngsters, on the other hand, show decreased activation in both posterior systems (left temporoparietal, left occipitotemporal), as well as increased activity in the left inferior frontal gyrus, right temporal, and tempoparietal regions. As a result, individuals continue to struggle to read unexpected words because they rely more heavily on right-sided posterior brain regions to read via memorization rather than sound–symbol links.
According to research, RD is highly familial and heritable. Up to 50% of children with RD have the disorder, and 50% of siblings of a child with RD have it as well. Twin studies have revealed strong concordance rates for RD, indicating that genetic variables account for 69 to 87 percent of the prevalence while environmental factors account for 13 to 30 percent.
Delayed speech, problems with pronunciation.
Problems with rhyming words and learning rhymes.
Difficulty with learning shapes, colors and how to write their own name.
Difficulty with retelling a story in the right order of events.
Lack of interest in playing games with language sounds (e.g., repetition, rhyming)
Failure to recognize letters in their own name
Trouble remembering names of letters, numbers, or days of the week [11, 12, 13].
Reading well below the expected level for age
Problems remembering the sequences
Difficulty in seeing similarities and differences in letters and words
Difficulty in spelling words
Receives reports of “not doing well in school”
Unable to read one-syllable words, such as “mat” or “top”
Problems in connecting sounds and letters (e.g., “big” for “got”)
When writing, frequently mistakes letters such as ‘d’ and ‘b’ or’m’ with ‘w’ Table 1.
Writes words backwards the majority of the time, such as writing ‘pit’ when the word ‘tip’ was intended.
Grammar issues, such as acquiring prefixes and suffixes.
Avoids reading aloud in class and reading-related activities
Requires lot of effort to reads single words and connected text
Has trouble pronouncing multisyllable words
Needs repeated reading to understand it on a regular basis [11, 12, 13].
Word level | Sentence level | |
---|---|---|
Reading | It is easy to read this sentence | |
Reabing | If is easy to reab fhis senfence |
Reader with dyslexia [17].
The reading subtests useful are
Woodcock-Johnson Psycho-Educational Battery- Revised, and
The Peabody Individual Achievement Test-Revised
Test of Word Reading Efficiency (TOWRE);
Dysgraphia is a specific learning disability diagnosed in childhood that affects a person’s handwriting ability and fine motor skills. It is characterized by poor writing skills that are significantly below for the child’s age, intelligence, and education, and cause problems with the child’s academic success or other important areas of life. Dysgraphia is also sometimes referred as spelling disorder and spelling dyslexia. Problems may include illegible handwriting, inconsistent spacing, and poor spatial.
planning on paper, poor spelling, and errors in grammar, punctuation, and poor handwriting. The children find difficulty composing writing as well as thinking and writing at the same time. This is linked to problems with visual-motor integration or fine motor skills.
Writing skills include both transcription and composition (text generation). Neuropsychological factors like difficulties in any one area (e.g., transcription, listening or reading comprehension, working memory) can delay skill development and efficient functioning in another. Research also throws light on role of genetics through twin studies and molecular genetic studies (Figures 1 and 2) [14, 15, 16].
Dysdraphia example by a dyslexic student [
Sample writing of Dysgraphic child [
Avoiding written work
Producing only a few words or sentences at a time when other pupils are completing many paragraphs
Excessive difficulties in composing a text (output failure)
Numerous technical faults of punctuation, grammar, word usage, sentence structure, and paragraph structure is observed
Omitting words frequently in sentences or unfinished sentences
Failure to capitalize the first letter of the first word in a sentence
Poorly organized written work (e.g., weak paragraph organization; poor sentence cohesiveness)
Illegible handwriting; incorrect use of upper- and lower-case letters, inverted characters; mixing of printing and cursive writing
Basic written activities, such as taking notes, are challenging as they require simultaneous listening.
Letters or sounds that are too similar are confused (e.g., “jumpt” for “jumped”; “caterpault” for “catapult”)
Inability to choose the correct spelling from two reasonable options (e.g., successful/succesfull; conscious/ consious; necessary/necessery)
Use of non-permissible letter strings consistently (e.g., “egszakt” for “exact”; discuss/diskus; “freeeqwnt” for “frequent”)
Inconsistent page positioning in terms of lines and margins
Uneven spacing between words and letters
Cramped or odd grip; holds the writing instrument very near to the paper, or holds thumb over two fingers and writes from the wrist (Figures 3 and 4) [17].
Sample writing of Dysgraphic child [
Sample writing of Dysgraphic child [
It refers to a type of specific learning disability that affects a person’s ability to understand numbers and learn math facts and difficulty in learning arithmetic. Individuals with this type of LD may also have poor comprehension of math symbols, may struggle with memorizing and organizing numbers, have difficulty telling time, or have trouble with counting. Problems with number or basic concepts are likely to show up early and problems related to reasoning appear in the later grades in students. Dyscalculic children may also be unable to sort important superfluous information, recognize the proper computing technique, or assess whether the solution they acquire is appropriate (Jordan & Hanich, 2003). Mathematical challenges are typically the most severe obstacles in the academic path of individuals with LD, and they frequently persist into high school (Figure 5).
Sample writing of Dycalculia [
Various psychological, neurological, genetic, environmental and emotional factors are responsible for dyscalculia. Inferior parietal sulcus plays a dominant role in numerical processing. MRI studies have shown decreased gray matter in the left parietal lobe of children suffering from Dyscalculia. Environmental factors like schooling, low-income households and affective factors like anxiety and motivation are some of the causal factors of poor mathematical abilities and psychosocial adversities in children.
A child with inadequate arithmetic skills may just rely on rote memorization for the first 2 or 3 years of primary school. As mathematics problems include discrimination and manipulation of spatial and numerical relationships, a youngster with math challenges will be impacted negatively sooner or later.
Individuals might have difficulty reading clocks to tell time, counting money, identifying patterns, remembering math facts, and solving mental math.
Counts with fingers because of difficulty with counting
Problems with differentiating between left and right
No alignment of digits and completing the arithmetic procedure in the wrong direction (e.g., left to right; top to bottom).
Poor comprehension of fractional concepts (1/2)
In older children (i.e., third grade and above), major impairments are evident in solving more complex arithmetic problems. And rapid retrieval of number facts (e.g., 4 × 9) and
Difficulty keeping scores or remembering score procedures in games, like bowling, etc. Often loses track of whose turn it is during games, like cards and board games. Has limited strategic planning ability for games, like chess [18].
Standardized tools to measure dyscalculia are,
The Keymath Diagnostic Arithmetic Test assesses understanding of mathematical content, function, and calculation, among other things. It is used to assess students in grades one through six.Woodcock–Johnson Achievement Battery-III
Test of Early Mathematical Abilities
Teacher Academic Attainment Scale (TAAS)
Child self- reported math anxiety scales. [11 items];
Mathematics Anxiety Scale for Children [11, 12, 13, 14, 15, 16].
APD is a deficit in neural processing of auditory stimuli that is not due to higher order language, cognitive or hearing loss and yet it is associated with difficulties in learning disorder [19, 20].
It is not a problem with understanding meaning but it means the brain of the affected child does not “hear” sounds in the usual way. It’s also known as Central Auditory Processing Disorder, and it’s a disorder that makes it difficult for sound to pass freely through the ear and be processed or interpreted by the brain. Even when the sounds are loud and clear enough to be heard, people with APD are unable to distinguish minor variations between sounds in words. They may be unable to filter distinct noises or mistake the order of sounds. In APD, the brain misinterprets the information received and processed from the ear [21].
APD can affect the way the child speaks as well as their ability to read, write, and spell. Affected children may drop the ends of words or mix up similar sounds and may find hard to talk with other people. They may not be able to process what others are saying and cannot come up with a response quickly. The child may find it hard to,
Understand speech in the presence of competing background noise or in resonating acoustic environments
Inability to localize the source of a signal
Issues with hearing on the phone
Inconsistent or inappropriate responses to requests for information
Difficulty following rapid speech
Frequent requests for repetition and/or rephrasing of information
Unable to follow directions
Difficulty or inability to detect the humor and sarcasm made by subtle changes in intonation.
Difficulty learning a foreign language or novel speech materials, especially technical language
Although the actual causes of APD are unknown, it is thought to be associated to illness like chronic ear infections, meningitis, or lead poisoning. APD can develop in patients who have neurological system illnesses such multiple sclerosis and also be caused by premature delivery, low weight, head injury, and genes (APD can run in families) [11, 12, 13, 14, 15, 16].
An audiologist can diagnose APD by conducting a series of advanced listening tests in which the child will listen to different sounds and respond when they hear them. However, children usually aren’t tested for APD until age 7 because their responses to the listening test may not be accurate when they are younger [14, 15, 16].
LPD is a type of Auditory Processing Disorder (APD) in which people have trouble putting meaning to the sound groups that make up words, phrases, and stories. While an APD affects how the brain interprets all sounds, a Language Processing Disorder (LPD) only impacts how language is processed [6]. This disorder arises when an individual has specific challenges in processing spoken language that impacts both receptive and expressive language. These language-related issues could be caused by a variety of circumstances, including a limited vocabulary, a concrete thinking style, difficulties remembering and keeping track of what is said, or difficulties organizing one’s thoughts. For example, children with a language-based LD may find it difficult to locate the appropriate words and phrases or to follow a fast-paced conversation. Language-based LDs also can make it difficult to write effectively: it might be difficult to organize ideas or determine the main topic of a written message [10].
Children with expressive language difficulties exhibit slow vocabulary growth, pronunciation difficulties, difficulty in expressing (single words, poor/wrong retrieval of words, poor answering, narrative and conversational skills) and grammatical difficulties. They will often use a less appropriate word because the right word will not come to them. They have problems understanding complex sentence structures and responding to questions (Figure 6) [17].
Expressive language difficulties [
Trouble with processing sounds affects, with sequencing, linking thoughts, and concepts
Need extra time to process incoming information
Miss nonverbal language cue
Do not understand jokes and laugh inappropriately or at the wrong times
Problems doing group work
Have difficulties giving or following directions
Conversations will be marked by long silences
Lack skill in responding to statements and questions (Hallahan & Kauffman, 2003) (Figure 7)
Expressive language difficulties [
Almost 65% of all communication is conveyed nonverbally. NLD is a disorder which is usually characterized by a significant discrepancy between higher verbal skills, weaker motor, visual–spatial and social skills. While it may sound like nonverbal learning disabilities (NVLD) relate to an individual’s inability to speak, it actually refers to difficulties in decoding nonverbal behaviors or social cues. Children with NVLD are often well-spoken and can write well, but struggle with subtle social cues and comprehension of abstract concepts or the nonverbal aspects of communication [1, 21, 22].
The typical characteristic of an individual with NLD (or NVLD) is having trouble interpreting nonverbal cues like facial expressions or body language, tone of voice and poor coordination. Hence they will have difficulty to make and keep friends
Struggle with life skills that require an understanding of spatial relationships, such as recognizing how parts fit together into a whole, completing jigsaw puzzles and building with blocks, learning routes for travel, and manipulating objects in space.
Difficulty in developing fine-motor skills those results in poor handwriting, difficulty learning to tie their shoelaces, and problems using small tools and utensils.
Are weak in executive functions or will find hard to sustain attention. They may have trouble handling new tasks, solving problems and remaining flexible in their thinking. They may also have difficulty staying focused, completing multi-step instructions, organizing tasks and materials and controlling their impulses.
Exhibit difficulty with reading comprehension or mathematical problem solving
Physically clumsy, often bumps into objects or people
Struggles with metaphors or abstract concepts and thinks of things in literal terms [21, 22, 23].
Individuals with visual perceptual/visual motor deficits have poor eye-hand coordination, lose their position frequently when reading, and struggle using pencils, crayons, glue, scissors, and other fine motor skills. When reading or completing tasks, they may also confuse similar-looking letters, have difficulty navigating their surroundings, or display atypical eye activity [8]. It impairs a person’s ability to grasp information that they see, as well as their ability to draw or copy and understand information collected by visual means. Due to faults in the way a person’s eyes move, sensory data gained through sight may be affected. These children’s visual impairments limit reading comprehension skills, cause a short attention span, and make it difficult to draw or copy information.
The brain can process visual information in a variety of ways, as per National Center for Learning Disabilities (2003) and individuals with this disability may experience difficulty in a variety of areas, and they are not limited to experiencing difficulties in just one of the categories listed below [23].
Difficulty with activities such as printing or copying, or learning to tie shoelaces.
Find hard to write, may put more pressure on a pencil or pen to control the motor movements, and may take much longer to write and experience fatigue with writing.
Have trouble orienting their body in space and may need more help to learn dressing or may confuse left and right.
Reversing superficially similar letters such as ‘p’ and ‘q’ or ‘m’ and ‘w’
Difficulty navigating around school or campus
Turns head while reading or hold paper at odd angles and closes one eye while reading
Often loses place while reading
Unable to recognize a word if only part of it is shown
Struggles with cut and paste
Shows poor organization on the page, messy words, irregular spacing, and misaligned letters [10, 23].
Learning impairments are usually linked to mental health issues. One of the most common disorder affecting school-aged children is specific learning disorders (SLD). According to the American Psychiatric Association (APA), SLD affects 5–15 percent of school-aged children from various languages and cultures. SLD frequently coexists with other neurodevelopmental and mental abnormalities, as well as psychiatric disorders. Many studies have found that children with SLD have both internalizing and externalizing psychiatric problems. There is a substantial link between ADHD and reading problems among the children with externalizing psychiatric disorders. Children with SLD are five times more likely to develop conduct disorder (CD). Despite the fact that there is a link between SLD and internalizing disorders in the literature, recent research have indicated a higher incidence of internalizing symptoms, with anxiety and depressive disorders at the top of the list. These mental co-morbidities with SLD are either a direct result of the same central processing pattern deficiencies that produce learning problems, or they are a source of frustration and academic failure. These issues are said to be part of a vicious cycle that leads the child towards severe cognitive and social–emotional impairment [24, 25, 26, 27].
SLD, previously known as a learning disorder includes a heterogeneous group of disorders manifested by significant difficulties in the acquisition and use of reading (dyslexia), writing (dysgraphia), or mathematical (dyscalculia) abilities despite intact senses, normal intelligence, proper motivation, and adequate socio-cultural opportunity. DSM-5 combines reading disorder, mathematics disorder, disorder of written expression and learning disorder into a single diagnosis under the classification of Specific learning disorder.
The Learning Disabilities Association of America and many other mental health practitioners regard the seven disorders as specific learning disabilities i.e. dyslexia, dysgraphia, dyscalculia, auditory processing disorder, language processing disorder, nonverbal learning disabilities and visual perceptual disabilities. The major causes of learning disabilities are inherited cause, genetic cause, neurobiological or brain injury, co-morbid disorders, environmental factors. They recognize autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) as related disorders that impact learning, though not specific learning disorders.
Dyslexia is characterized by difficulties with inaccurate word recognition and poor spelling and decoding abilities resulting from a deficit in the phonological component of language. Dysgraphia is characterized by poor writing skills like poor spelling, errors in grammar and punctuation, and poor handwriting. Mathematics disorder refers to impairment in the development of arithmetic skills, including computational procedures used to solve arithmetic problems and the retrieval of basic arithmetic facts from long-term memory. Language Processing Disorder (LPD) relates to the difficulties in processing of expressive language and/or receptive language. Non-verbal learning disability refers to problems in understanding nonverbal cues like facial expressions or body language. Visual processing disorder includes trouble drawing or copying, inability to detect differences in shapes or letters, and letter reversals.
SLD could cause complications if not remedied earlier. Intense and focused instruction may in fact alter the brain activation profiles observed in children with SLD.
Hence there is a need to advocate for intense and focused instruction in each of the affected academic domains.
One of the most important techniques for studying crystals is electron crystallography. Recently, a new method, rotation electron diffraction (RED), has been developed for collecting three-dimensional (3D) electron diffraction data by combining electron beam tilt and goniometer tilt in a transmission electron microscope [1, 2, 3, 4]. RED is capable of structure determination as well as phase identification of unknown crystals. It is easier, much faster, and more straightforward than powder X-ray diffraction and other electron microscopy techniques, such as high-resolution transmission electron microscopy (HRTEM). There is no enigma in the determination of unit cell, space group and indexing of diffraction peaks in RED [5].
The low-density structures such as zeolites and open-framework compounds are solved by RED method [5, 6]. Since, complex dense intermetallic compounds such as quasicrystal approximants contain heavy elements and thus suffer more from dynamical scattering, it is interesting to see if they can also be solved from RED data. Quasicrystals possess aperiodic long-range order associated with crystallographically forbidden rotational symmetries (5-, 8-, 10-, or 12-fold) and exhibit many outstanding physical properties [7, 8, 9, 10, 11, 12, 13]. Several breakthrough experiments performed by Dan Shechtman in 1982 on rapidly solidified Al-Mn alloys have led to the discovery of quasicrystals. It exhibits sharp diffraction peaks with icosahedral symmetry [14]. Quasicrystals exhibit unique physical properties which strongly differ from the properties of metals, insulators, and crystalline or amorphous phases [7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21]. Thus, these materials have the potential to be used in many areas of advanced technology. Out of the many alloy systems which possess quasicrystalline phases, Al-based quasicrystalline alloy systems are easily available, cheap, and non-toxic.
The most critical aspect of quasicrystals from the experimental and theoretical point of view is to solve their structures. Their structures have been solved theoretically using a sequence of periodic structures with growing unit cells [22, 23, 24]. There exist also a number of crystalline phases resembling the quasicrystals, known as approximant phases [22]. The diffraction patterns of approximant phases are closely related to those of quasicrystals as their structures are built up by the same clusters as in quasicrystals. Quasicrystals and their approximant phases have similar electron diffraction patterns and chemical compositions [25, 26, 27, 28, 29, 30, 31], showing that they have similar local structures. One approach is to determine the structures of approximants. This helps us to get a deep understanding of the relationships between quasicrystals and their approximant phases. Thus, approximant phases may hold the key to determine the structures of quasicrystals.
The HRTEM and high-angle annular dark-field (HAADF) studies of Al-Co-Ni decagonal quasicrystals suggest that the basic structure is composed of 2 nm clusters with fivefold rotational symmetry [32, 33, 34]. A series of pseudo-decagonal (PD) quasicrystal approximants in Al-Co-Ni with almost 10-fold symmetry of their electron diffraction patterns have been found and described [35, 36]. Out of those approximants, only two structures, namely, PD4 [37] and PD8 (also called the W-phase) [38], have been solved to atomic resolution by X-ray crystallography. The PD1, PD2, PD3, and PD5 structures were solved at low resolution from the limited information provided by electron diffraction patterns, unit cell dimensions, and HRTEM images [39]. An attempt to solve the structures of PD1 and PD2 in Al71Co14.5Ni14.5 alloy by maximum entropy Patterson deconvolution was reported by Estermann et al. [40]. Since these two structures were found to intergrow, thus there was a serious problem in the application of X-ray diffraction. This problem can be eliminated in the case of electron crystallography as much smaller crystals (<1 mm3) are needed for electron diffraction. Recently, we have solved the structures of PD2 and PD1 by RED method [41, 42]. The present chapter deals with the results and discussion of these two structures.
The decagonal quasicrystals are described by a quasiperiodic arrangement of clusters [43, 44, 45, 46]. All decagonal quasicrystals in Al-Co-Ni and their high-order approximants are composed of 2 nm wheel clusters [47, 48, 49, 50, 51]. The arrangement of atoms within the clusters imposes restrictions on the cluster arrangements, e.g., an overlapping of clusters [52, 53, 54, 55, 56]. To understand the structure of quasicrystals, it is important to find the details of the atomic arrangements within the 2 nm wheel clusters and their packing into a 3D crystal. The geometrical building principles of Al-Co-Ni, Al-Co-Cu, and Al-Fe-Ni decagonal quasicrystals and their approximant phases in terms of a fundamental unit cluster-based approach that leads to a unifying view of all these phases have been discussed [57]. This unit cluster has ~2 nm diameter.
The RED method has been applied for ab initio structure determination of PD2 (
The details of the preparation methods of Al71Co14.5Ni14.5 nominal composition are reported elsewhere [41, 42]. Powder X-ray diffraction examination revealed a diffraction pattern typical of PDs [35]. A piece of the annealed sample was powdered and dispersed in ethanol and treated by ultrasonification for 2 min. A droplet of the suspension was transferred onto a copper grid (with carbon film). The 3D-RED data were collected on a JEOL JEM-2100 LaB6 microscope at 200 kV [1]. The single-tilt tomography sample holder was used for data collection. In RED, we combine electron beam tilt and goniometer tilt (Figure 1). The RED data collection software package was used which controls 3D-RED data collection in an automated way [1, 4, 58]. The selected area diffraction patterns were collected at each tilt angle from a μm-sized crystal (Figure 1(b)). For RED data collection, electron beam tilt with many small steps and goniometer tilt with larger steps was combined to cover a large part of reciprocal space. Table 1 gives the details of the RED data collection and crystallographic information for the PD2 and PD1 quasicrystal approximants. Energy-dispersive spectroscopy (EDS) analysis was carried out on the same crystal after the RED data collection which showed that the composition was close to the nominal one.
(a) Ray diagram of the electron beam rotation, showing beam tilt and goniometer tilt. (b) a single crystal of size ~2.0 × 1.0 × <0.1 mm was used for the RED data collection. (c) and (d) two diffraction patterns of PD2 which are 1.0° (20 frames) apart. Reproduced with permission of the International Union of Crystallography (
Name | Pseudo-decagonal (PD2) quasicrystal approximant | Pseudo-decagonal (PD1) quasicrystal approximant |
---|---|---|
Chemical formula | Al37(Co,Ni)15.5 | Al77(Co/Ni)31 |
Temperature (K) | 298 | 298 |
Wavelength (Å) | 0.02508 | 0.02508 |
Crystal system | Orthorhombic | Orthorhombic |
Space group | ||
Unit cell parameters (Å) | ||
Volume (Å3) | 3075.7 | 5933.68 |
Density (calculated in Mg cm−3) | 4.132 | 4.374 |
Crystal size (μm) | 2.0 × 1.0 × <0.1 | 2.0 × 2.0 × <0.1 |
Tilt range (°) | −74.3 to +36.0 | +29.5 to −64.6 |
Tilt step (°) | 0.05 | 0.05 |
Exposure time/frame (s) | 0.5 | 0.2 |
Total data collection time (min) | 90 | 90 |
No. of frames | 2255 | 2050 |
Program for structure determination | ||
Resolution (Å) | 1.0 | 1.0 |
Completeness (%) | 89.3 | 94.5 |
Reflections collected | 8153 | 7070 |
R(int) | 0.33 | 0.26 |
Observed unique reflections ( | 1799 | 2588 |
Parameters/restraints | 156 with 0 restraint | 325 with 0 restraint |
Goodness-of-fit on F2 | 4.155 | 2.854 |
Final R indices ( | R1 = 0.4285, wR2 = 0.7023 | R1 = 0.3606, wR2 = 0.6641 |
R (all reflections) | 0.4326 | 0.3671 |
Highest peak and deepest hole | 1.98 and − 2.56 | 1.31 and − 1.42 |
Crystallographic data, RED experimental parameters, and structure refinement details for the PD2 and PD1 quasicrystal approximant structures.
Reproduced with permission of the International Union of Crystallography (https://scripts.iucr.org/cgi-bin/paper?HE5621 & https://scripts.iucr.org/cgi-bin/paper?jo5016) [41, 42].
The software package RED data processing was used for the data processing of the collected frames [4, 58], including direct beam-shift correction, peak search, unit cell determination, indexing of reflections, and intensity extraction. ED frames collected were combined into a 3D data set for reciprocal space reconstruction. After reciprocal space had been reconstructed, the unit cell parameters, space group, reflection indices, and diffraction intensities were determined. The indexing of all reflections has been done. For the determination of space group, the two-dimensional slices cut from the 3D-RED data along the (
The 3D reciprocal space can be obtained by combining the series of electron diffraction frames. RED data processing program is used for the reciprocal space reconstruction of the electron diffraction data. The unit cell dimensions for PD2 and PD1 were found to be
(a) The entire 3D reciprocal lattice of PD2 obtained from the 3D-RED data viewed along c*. (b) the original data set projected along b*. the odd layers (corresponding to the 8.2 Å c-axis, shown in red) are much weaker than the even layers (corresponding to a 4.1 Å c axis). Reproduced with permission of the International Union of Crystallography (
Figure 2(b) shows the original data set projected along
Selected area electron diffraction pattern of the hk0 layer of PD2. This electron diffraction pattern was collected on a JEOL JEM-2000FX microscope. Reproduced with permission of the International Union of Crystallography (
Figure 4(a)–(c) show the 2D slices (
Two-dimensional slices of the reconstructed reciprocal lattice obtained from the 3D-RED data. (a) (hk0), (b) (h0l), and (c) (0kl). The layers shown in red colour in (b) and (c) for c = 8.2 Å are much weaker than the even layers of c = 4.1 Å. reproduced with permission of the International Union of Crystallography (
Figure 5(a)–(c) show 2D slices of (
(a)–(c) 2D slices of (hk1) and (hk − 1), (hk2) and (hk − 2), and (hk3) and (hk-3) for c = 4.1 Å obtained from experimental RED data. Here, two layers of each are combined and shown together. The white reflections correspond to hkl while yellow corresponds to hk − l layers. (d)–(f) simulated kinematical electron diffraction patterns after the final refinement of the structure model using c = 4.1 Å [(hk1), (hk2) and (hk3), respectively]. Reproduced with permission of the International Union of Crystallography (
Based on the systematic absences for the unit cell with
Since the procedure followed for the structure solution and refinement using RED data is same for both the structures, we discuss here only the step-by-step details in the structure determination of PD2 structure. The details for the PD1 structure is reported elsewhere [42]. The crystallographic data, RED experimental parameters, and structure refinement details for the PD2 and PD1 structures are given in Table 1. In the case of PD2, a total of 8153 reflections, of which 1799 are unique, within 1.0 Å resolution, were collected. The structure model of PD2 was deduced by direct methods using
(a) HRTEM image of PD2 with 2 × 2 unit cells taken along the c axis [
Comparing the structure model of PD2 generated by
Figure 6(c) shows the atomic arrangement in the
A total of 7070 reflections were collected for the PD1 structure. Out of which 2588 are unique. The data completeness is 94.5% for the reflections with d ≥ 1.0 Å. The Rint value is found to be 0.26, which is much higher than that for single-crystal X-ray diffraction but normal for electron diffraction data. The causes for this relatively poor data quality compared to single-crystal X-ray diffraction are currently under investigation. The program
(a) HRTEM image of PD1 with 2 × 2 unit cells, taken along the c axis [
(a) Circular wheel clusters of PD1 with PD2 obtained from RED data are compared. (b) PD1 and PD2 show identical arrangements of Ni/Co atoms present at z = 0.25 (red) and z = 0.75 (red with yellow cross) within the wheel cluster. Although, most of the Al atoms appear in similar locations within the wheels in PD1 and PD2, there are some differences. Reproduced with permission of the International Union of Crystallography (
The positions for all stronger Co/Ni scatterers are correct, while the positions of weaker Al scatterers are more uncertain. As discussed earlier, few Al atoms may be missing, few may be misplaced, and several may have split occupancies or could be shared Al/Co and/or Al/Ni sites. With the present data quality of electron diffraction, such fine details cannot be determined unambiguously. Some work has been done and some in progress on the ways to compensate the problems with respect to quality of data and absorption that combine to give electron diffraction intensity data that are inferior to those collected by X-ray diffraction. In the present case, the structure refinement can be done, and at least the Co/Ni atoms were found to be stable during refinement. The arrangement of Co/Ni atoms is in excellent agreement with previous studies by single-crystal X-ray diffraction for PD8 [38] and PD4 [37] and with the low-resolution projections obtained by HRTEM on PD1 [39].
Based on the results described and discussed in this chapter, it is proven that rotation electron diffraction method is an effective method to solve the structures of a rather complex and dense quasicrystal approximants. The structural details of pseudo-decagonal (PD) quasicrystal approximants PD2 and PD1 discussed in this chapter helped us to understand the atomic arrangements within the 2 nm wheel clusters. These are one of the most complex structures ever solved to atomic resolution by electron diffraction. The structural models obtained from the RED data agree well with the high-resolution transmission electron microscopy images.
One of the author (D. Singh) gratefully acknowledges the financial support by Department of Science and Technology (DST), New Delhi, India, in the form of INSPIRE Faculty Award [IFA12-PH-39]. The authors thank the Swedish Research Council (VR), the Swedish Governmental Agency for Innovation Systems (VINNOVA), and the Knut and Alice Wallenberg Foundation for the financial support through the project grant 3DEM-NATUR.
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Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. 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