Socio-economic characteristics of respondents.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5461",leadTitle:null,fullTitle:"Hair and Scalp Disorders",title:"Hair and Scalp Disorders",subtitle:null,reviewType:"peer-reviewed",abstract:"This textbook contains the latest advances and scientific knowledge from the leading experts in hair biology, hair disorders, and clinical trichology. The book consists of ten sections in which hair biology, hair genetics, hair diagnostics, hair loss types, pathogenesis, treatment options, and restoration techniques are discussed. This book also emphasizes on various genetic and nongenetic alopecia types, differential diagnosis, and the measurement of hair loss. One chapter of the book is devoted to natural products for hair care and treatment. We believe that this textbook will serve as a comprehensive guide to many physicians dealing with hair disorders in their clinical practice.",isbn:"978-953-51-3098-7",printIsbn:"978-953-51-3097-0",pdfIsbn:"978-953-51-4857-9",doi:"10.5772/63002",price:139,priceEur:155,priceUsd:179,slug:"hair-and-scalp-disorders",numberOfPages:386,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"87c272cade1ee498e1b4d6051aa8d41e",bookSignature:"Zekayi Kutlubay and Server Serdaroglu",publishedDate:"May 3rd 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5461.jpg",numberOfDownloads:56227,numberOfWosCitations:18,numberOfCrossrefCitations:20,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:31,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:69,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 18th 2016",dateEndSecondStepPublish:"May 9th 2016",dateEndThirdStepPublish:"August 13th 2016",dateEndFourthStepPublish:"November 11th 2016",dateEndFifthStepPublish:"December 11th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"64792",title:"Dr.",name:"Zekayi",middleName:null,surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay",profilePictureURL:"https://mts.intechopen.com/storage/users/64792/images/5583_n.png",biography:"Zekayi Kutlubay, MD, is a chief physician of Istanbul University Cerrahpasa Medical Faculty Hospital. He is also an associate professor in the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty in Turkey. He has coauthored over 40 publications and supervised several master, doctoral, and postdoctoral students. His actual research interests are focused on psoriasis, pediatric dermatology, autoimmune bullous diseases, urticaria and allergic diseases, Behçet’s disease, vasculitis, lasers, cosmetic dermatology, facial rejuvenation, hair diseases, mesotherapy, botulinum toxin, and fillers.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Istanbul University Cerrahpaşa",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"64794",title:"Mr.",name:"Server",middleName:null,surname:"Serdaroglu",slug:"server-serdaroglu",fullName:"Server Serdaroglu",profilePictureURL:"https://mts.intechopen.com/storage/users/64794/images/5584_n.png",biography:"Server Serdaroglu, MD, is the head of the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty. He is also a professor in the Department of Dermatology at Istanbul University Cerrahpasa Medical Faculty in Turkey. He has coauthored over 30 publications and supervised several master, doctoral, and postdoctoral students. His actual research interests are focused on psoriasis, hair diseases, pediatric dermatology, autoimmune bullous diseases, urticaria and allergic diseases, lasers, and cosmetic dermatology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1003",title:"Trichology",slug:"trichology"}],chapters:[{id:"53795",title:"Introductory Chapter: Hair Loss",doi:"10.5772/66984",slug:"introductory-chapter-hair-loss",totalDownloads:2386,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Zekayi Kutlubay and Server Serdaroglu",downloadPdfUrl:"/chapter/pdf-download/53795",previewPdfUrl:"/chapter/pdf-preview/53795",authors:[{id:"64792",title:"Dr.",name:"Zekayi",surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay"}],corrections:null},{id:"53880",title:"Anatomy and Physiology of Hair",doi:"10.5772/67269",slug:"anatomy-and-physiology-of-hair",totalDownloads:7684,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:1,abstract:"Hair is one of the characteristic features of mammals and has various functions such as protection against external factors; producing sebum, apocrine sweat and pheromones; impact on social and sexual interactions; thermoregulation and being a resource for stem cells. Hair is a derivative of the epidermis and consists of two distinct parts: the follicle and the hair shaft. The follicle is the essential unit for the generation of hair. The hair shaft consists of a cortex and cuticle cells, and a medulla for some types of hairs. Hair follicle has a continuous growth and rest sequence named hair cycle. The duration of growth and rest cycles is coordinated by many endocrine, vascular and neural stimuli and depends not only on localization of the hair but also on various factors, like age and nutritional habits. Distinctive anatomy and physiology of hair follicle are presented in this chapter. Extensive knowledge on anatomical and physiological aspects of hair can contribute to understand and heal different hair disorders.",signatures:"Bilgen Erdoğan",downloadPdfUrl:"/chapter/pdf-download/53880",previewPdfUrl:"/chapter/pdf-preview/53880",authors:[{id:"193661",title:"Dr.",name:"Bilgen",surname:"Erdoğan",slug:"bilgen-erdogan",fullName:"Bilgen Erdoğan"}],corrections:null},{id:"53430",title:"Mechanism of Hair Loss from the Point of View of Epidermal Cell Polarity",doi:"10.5772/66735",slug:"mechanism-of-hair-loss-from-the-point-of-view-of-epidermal-cell-polarity",totalDownloads:2642,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The epidermis and hair follicle epithelium have a polarized stratified architecture, and epidermal homeostasis is maintained by stem cell and progenitor populations present in the basal layer of the interfollicular epidermis and in different compartments of the hair follicle. Atypical protein kinase Cs (aPKCs—a subgroup of the PKC family) are localized to tight junctions and regulate the apico-basal epithelial polarity in simple epithelia. In the stratified epidermis, aPKCs are expressed in the basal layer and are implicated in the regulation of oriented cell division by localizing to the apical pole of basal cells during mitosis. Mutant mice harboring epidermis-specific deletion of aPKCλ showed progressive hair loss, abnormal hair cycling, an increase of asymmetric cell division in the epidermis and hair follicles, and a gradual decrease in the hair follicle stem cell (HFSC) population. Lineage tracing analysis has demonstrated that mutant HFSCs lose their stemness and become more committed proliferating progenitors. Moreover, the expressions of quiescence-inducing factors (Bmp6 and Fgf18) were suppressed in the mutant hair follicles. These results clarify a novel function of aPKCλ in maintaining the quiescence of HFSCs and suggest that epidermal cell polarity is a new clue to understanding the pathogenesis of hair loss.",signatures:"Shin-Ichi Osada",downloadPdfUrl:"/chapter/pdf-download/53430",previewPdfUrl:"/chapter/pdf-preview/53430",authors:[{id:"190768",title:"Associate Prof.",name:"Shin-Ichi",surname:"Osada",slug:"shin-ichi-osada",fullName:"Shin-Ichi Osada"}],corrections:null},{id:"53304",title:"Hair Follicle Reconstruction and Stem Cells",doi:"10.5772/66707",slug:"hair-follicle-reconstruction-and-stem-cells",totalDownloads:2183,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"De novo hair follicle (HF) formation in embryonic skin and hair growth in postnatal skin are the result of epithelial-mesenchymal interactions between specialized mesenchymal dermal papilla (DP) and epithelial stem cells that give rise to hairs. Adult HF is a valuable source of different lineages of stem cells (SCs) with morphogenetic potential. Epithelial stem cells are residing in the special compartment of HF (the bulge) and can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. This review summarizes the current knowledge on key characteristics of HF SC populations in terms of regenerative potential. General biological principles that govern the mesenchymal-epithelial interactions within the HF and the signaling pathways that control HF development are discussed. The main focus is on recent approaches to reconstruct folliculogenesis in vitro and perspectives of the tissue engineering in alopecia therapy.",signatures:"Ekaterina P. Kalabusheva, Elina S. Chermnykh, Vasily V. Terskikh and\nEkaterina A. Vorotelyak",downloadPdfUrl:"/chapter/pdf-download/53304",previewPdfUrl:"/chapter/pdf-preview/53304",authors:[{id:"191045",title:"Dr.",name:"Ekaterina",surname:"Vorotelyak",slug:"ekaterina-vorotelyak",fullName:"Ekaterina Vorotelyak"},{id:"191046",title:"Ms.",name:"Ekaterina",surname:"Kalabusheva",slug:"ekaterina-kalabusheva",fullName:"Ekaterina Kalabusheva"},{id:"195509",title:"Prof.",name:"Vasily",surname:"Terskikh",slug:"vasily-terskikh",fullName:"Vasily Terskikh"},{id:"195510",title:"Dr.",name:"Elina",surname:"Chermnykh",slug:"elina-chermnykh",fullName:"Elina Chermnykh"}],corrections:null},{id:"54131",title:"The Histological Mechanisms of Hair Loss",doi:"10.5772/67275",slug:"the-histological-mechanisms-of-hair-loss",totalDownloads:2316,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The growing hair resists pulling out of the skin in particular site, where the keratinization of hair cortex and hair cuticle cells as well as the cells of the hair inner root sheath (IS) (being in tight contact) are advanced enough to make them rather strong but lower the level where the hair separates from the hair inner root sheath. The hair which does not grow is kept for some time within the skin by the direct contact of the keratinized hair cortex cells with the cells of the hair outer root sheath. Such contact is absent at the phase of growing hair and even in the case of proliferation inhibition in the follicle bulb causing the lack of hair resistance to pulling it out of the skin several days after inhibition induction.",signatures:"Vsevolodov Eduard Borisovich",downloadPdfUrl:"/chapter/pdf-download/54131",previewPdfUrl:"/chapter/pdf-preview/54131",authors:[{id:"191715",title:"Dr.",name:"Eduard",surname:"Vsevolodov",slug:"eduard-vsevolodov",fullName:"Eduard Vsevolodov"}],corrections:null},{id:"53525",title:"Trichoscopy and Trichogram",doi:"10.5772/66836",slug:"trichoscopy-and-trichogram",totalDownloads:2583,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hair and scalp examination techniques can be classified into three categories: noninvasive methods (clinical history, general examination, photography, hair count, weighing shed hair, pull test, global hair counts, dermoscopy, electron microscopy, laser scanning microscopy, etc.); semi‐invasive methods (the trichogram, unit areatrichogram); and invasive methods (biopsies in cicatritial alopecia). Scalp dermoscopy or trichoscopy is one of thenoninvasive techniques for the evaluation of patients with hair loss that allows for magnified visualization of the hair and scalp skin. It may be performed with a manual dermoscope (10× magnification) or a videodermoscope (up to 1000× magnification). This method is simple, quick, and easy to perform, is well‐accepted by patients, and is useful for monitoring treatment, determining severity of the disease and follow‐up. It is a simple, minimally invasive and rapid technique for measuring hair follicle activity. Trichogram represents a semi‐invasive technique for the evaluation of patients with hair loss that allows the microscopic examination of hairs plucked from the scalp and provides information about the state of the proximal end of the hair shaft and the distal end. The trichogram is a useful complementary tool for clinical evaluation, diagnosis, and the monitoring of treatment response.",signatures:"Melike Kibar",downloadPdfUrl:"/chapter/pdf-download/53525",previewPdfUrl:"/chapter/pdf-preview/53525",authors:[{id:"189899",title:"Dr.",name:"Melike",surname:"Kibar Ozturk",slug:"melike-kibar-ozturk",fullName:"Melike Kibar Ozturk"}],corrections:null},{id:"53231",title:"Alopecia Areata",doi:"10.5772/66594",slug:"alopecia-areata",totalDownloads:2544,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Alopecia areata is an organ-specific autoimmune disease targeting hair follicles. It causes nonscarring hair loss. The prevalence rate of the disease is approximately 1 in 1000 people worldwide. The condition is most commonly seen as circular areas of hair loss, but it may sometimes be as extensive as to involve the whole scalp or whole body. The complex pathophysiology of alopecia areata involves an autoimmune basis. Association of alopecia areata with other autoimmune diseases, such as thyroiditis and vitiligo, and the good response of patients to immunosuppressive treatment support an autoimmune etiology. Although some poor prognostic signs are defined, the course of the disease is unpredictable and the response to treatment can be variable. To date, there are neither preventive nor curative measures to deal with the condition. First-line therapy for patchy disease is topical and intralesional steroids, whereas extensive disease is conventionally managed with immunotherapy. New treatment agents, such as excimer laser, low-dose recombinant interleukin 2, Janus kinase inhibitors, and simvastatin/ezetimibe, are promising.",signatures:"Burhan Engin, Muazzez Çiğdem Oba and Yalçın Tüzün",downloadPdfUrl:"/chapter/pdf-download/53231",previewPdfUrl:"/chapter/pdf-preview/53231",authors:[{id:"64793",title:"Prof.",name:"Burhan",surname:"Engin",slug:"burhan-engin",fullName:"Burhan Engin"}],corrections:null},{id:"54176",title:"Telogen Effluvium",doi:"10.5772/66975",slug:"telogen-effluvium",totalDownloads:1938,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Telogen effluvium (TE) is a noninflammatory disease characterized by diffuse loss of telogen hair. It is the most frequent cause of diffuse hair loss and the actual incidence of the disease is not known. According to the underlying etiology, TE could be physiologically and pathologically classified. The evaluation of a patient with TE includes a detailed history, physical examination, and laboratory tests. The patients should be questioned in terms of TE subtype, duration, and clinical course of hair loss. The most important point in the treatment of TE is to consult about the natural course of the disease.",signatures:"Emin Ozlu and Ayse Serap Karadag",downloadPdfUrl:"/chapter/pdf-download/54176",previewPdfUrl:"/chapter/pdf-preview/54176",authors:[{id:"188975",title:"Associate Prof.",name:"Ayse Serap",surname:"Karadag",slug:"ayse-serap-karadag",fullName:"Ayse Serap Karadag"},{id:"189961",title:"Dr.",name:"Emin",surname:"Ozlu",slug:"emin-ozlu",fullName:"Emin Ozlu"}],corrections:null},{id:"54721",title:"Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways",doi:"10.5772/67845",slug:"androgenic-alopecia-cross-talk-between-cell-signal-transduction-pathways",totalDownloads:2906,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.",signatures:"Anastasia Nesterova and Anton Yuryev",downloadPdfUrl:"/chapter/pdf-download/54721",previewPdfUrl:"/chapter/pdf-preview/54721",authors:[{id:"189400",title:"Dr.",name:"Anastasia",surname:"Nesterova",slug:"anastasia-nesterova",fullName:"Anastasia Nesterova"},{id:"205662",title:"Dr.",name:"Anton",surname:"Yuryev",slug:"anton-yuryev",fullName:"Anton Yuryev"}],corrections:null},{id:"53933",title:"Cicatricial Alopecias",doi:"10.5772/67277",slug:"cicatricial-alopecias",totalDownloads:1760,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Primary cicatricial alopecias (PCA) are a rare group of disorders in which the hair follicle is the main target of destructive inflammation resulting in irreversible hair loss with scarring of affected lesions. Inflammation may predominantly involve lymphocytes or neutrophils. Cicatricial alopecias that mainly involve lymphocytic inflammation include lichen planopilaris, discoid lupus erythematosus, pseudopelade (Brocq), central centrifugal alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. Cicatricial alopecias that are due to predominantly neutrophilic inflammation include folliculitis decalvans and dissecting cellulitis of the scalp. Acne keloidalis, acne necrotica, and erosive pustular dermatosis are cicatricial alopecias with a mixed inflammatory infiltrate.",signatures:"Ibrahim Halil Yavuz, Goknur Ozaydin Yavuz and Serap Gunes Bilgili",downloadPdfUrl:"/chapter/pdf-download/53933",previewPdfUrl:"/chapter/pdf-preview/53933",authors:[{id:"190495",title:"Associate Prof.",name:"Serap Gunes",surname:"Bilgili",slug:"serap-gunes-bilgili",fullName:"Serap Gunes Bilgili"},{id:"191273",title:"Dr.",name:"Goknur",surname:"Ozaydin Yavuz",slug:"goknur-ozaydin-yavuz",fullName:"Goknur Ozaydin Yavuz"},{id:"191275",title:"Dr.",name:"Ibrahim Halil",surname:"Yavuz",slug:"ibrahim-halil-yavuz",fullName:"Ibrahim Halil Yavuz"}],corrections:null},{id:"53947",title:"Infections, Infestations and Neoplasms of the Scalp",doi:"10.5772/67278",slug:"infections-infestations-and-neoplasms-of-the-scalp",totalDownloads:3433,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter reviews common cutaneous infections, infestations, and neoplasms of the scalp. Infections of the scalp are subdivided into three major groups. The most seen are: (1) Bacterial: Folliculitis, folliculitis decalvans, tufted hair folliculitis and acne keloidalis nuchae. (2) Fungal: Tinea capitis, favus and kerion celsi. (3) Protozoal: Syphilitic alopecia. Pediculosis capitis is the most common worldwide infestation of the scalp. The neoplasms of the scalp are large group of different diseases due to arising different origin. In the following section, trichilemmal cyst, proliferating trichilemmal cyst, nevus sebaceous and cylindroma are discussed in detail.",signatures:"Filiz Canpolat",downloadPdfUrl:"/chapter/pdf-download/53947",previewPdfUrl:"/chapter/pdf-preview/53947",authors:[{id:"191617",title:"Associate Prof.",name:"Filiz",surname:"Canpolat",slug:"filiz-canpolat",fullName:"Filiz Canpolat"}],corrections:null},{id:"53306",title:"Trichotillomania and Traction Alopecia",doi:"10.5772/66746",slug:"trichotillomania-and-traction-alopecia",totalDownloads:2387,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Trichotillomania and traction alopecia are chronic habitual disorders characterized by repetitive pulling of hair that results in alopecia. They are commonly observed in children and adolescents but may present in adults due to occupational or traditional behavioral patterns. Trichotillomania (hair‐pulling disorder) has been described more than a century ago, but we still have very limited data about its etiology and treatment. It is classified under the obsessive‐compulsive and related disorders along with hoarding disorder, skin‐picking disorder (excoriation) and body dysmorphic disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5; American Psychiatric Association, May 2013). Traction alopecia is defined as loss of hair caused by repetitive or continuous and prolonged tension applied to the hair, usually on the scalp periphery and associated with mechanical traction of hair due to occupational behavioral patterns such as ballerinas or traditional behavioral patterns of hairstyles that cause tension. We aim to overview the clinical and diagnostic features of trichotillomania and traction alopecia and review the therapeutic options of these disorders in this chapter.",signatures:"Tugba Kevser Uzuncakmak, Melek Aslan Kayıran, Burak Tekin and\nFiliz Cebeci",downloadPdfUrl:"/chapter/pdf-download/53306",previewPdfUrl:"/chapter/pdf-preview/53306",authors:[{id:"193582",title:"Dr.",name:"Tugba Kevser",surname:"Uzuncakmak",slug:"tugba-kevser-uzuncakmak",fullName:"Tugba Kevser Uzuncakmak"},{id:"193587",title:"Dr.",name:"Filiz",surname:"Cebeci",slug:"filiz-cebeci",fullName:"Filiz Cebeci"},{id:"193588",title:"Dr.",name:"Melek",surname:"Aslan Kayıran",slug:"melek-aslan-kayiran",fullName:"Melek Aslan Kayıran"},{id:"193589",title:"Dr.",name:"Burak",surname:"Tekin",slug:"burak-tekin",fullName:"Burak Tekin"}],corrections:null},{id:"52801",title:"Psychosocial Aspects of Hair Loss",doi:"10.5772/66156",slug:"psychosocial-aspects-of-hair-loss",totalDownloads:2507,totalCrossrefCites:6,totalDimensionsCites:7,hasAltmetrics:1,abstract:"Hair loss (alopecia) is a common dermatological condition that affects men and women of all ages. It can be due to a wide variety of causes including scarring and non-scarring diseases. Although alopecia is not a life-threatening condition, it has significant psychological impact on the quality of life. Mental disorders such as anxiety, depression, social phobia, posttraumatic stress disorder, and suicidal thoughts are increased among alopecia patients. On the other hand, alopecia frequency increases during the course of psychological disorders. In this chapter, psychosocial aspects of hair loss and the relationship between alopecia and psychological disorders are reviewed.",signatures:"Hilal Gokalp",downloadPdfUrl:"/chapter/pdf-download/52801",previewPdfUrl:"/chapter/pdf-preview/52801",authors:[{id:"193580",title:"M.D.",name:"Hilal",surname:"Gokalp",slug:"hilal-gokalp",fullName:"Hilal Gokalp"}],corrections:null},{id:"54484",title:"Hair Loss in Children, Etiologies, and Treatment",doi:"10.5772/67379",slug:"hair-loss-in-children-etiologies-and-treatment",totalDownloads:2253,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hair loss in children is a common and important complaint in dermatology and pediatric clinics and can be considered as a difficult and challenging problem in some cases. Early management is needed as this has its effect on development of normal mental and physical growth of children. Alopecia or hair loss is of particular concern in pediatric group, as it is associated with more significant psychological consequences in this growing age group and has patterns that are different from that seen in adults. There are common and uncommon causes for this complaint, and this usually covers a broad differential diagnosis. This chapter has been written in an attempt to distinguish the types of hair loss (acquired and congenital, common and uncommon), to facilitate the diagnostic causes of this problem, and finally to reach a proper treatment.",signatures:"Khitam Al-Refu",downloadPdfUrl:"/chapter/pdf-download/54484",previewPdfUrl:"/chapter/pdf-preview/54484",authors:[{id:"51233",title:"Dr.",name:"Khitam",surname:"Al-Refu",slug:"khitam-al-refu",fullName:"Khitam Al-Refu"}],corrections:null},{id:"53490",title:"Follicular Unit Extraction (FUE) Hair Transplantation",doi:"10.5772/66837",slug:"follicular-unit-extraction-fue-hair-transplantation",totalDownloads:2480,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Throughout the world, over 60% of men and 50% of women suffer from androgenetic alopecia and irreversible hair loss. This type of hair loss is a seminatural process, and medication can only temporarily inhibit it. At the moment, the solution for either androgenetic alopecia or other irreversible hair loss problems is the hair transplantation. Besides androgenetic alopecia, the many irreversible hair losses are being applied successfully by hair transplantation. In the past 10–15 years, a new hair restoration technique was introduced. This method is called follicular unit extraction (FUE) technique. FUE is an alternative which allows for quick extraction of follicular unit grafts. The hair transplantation can be used in various problems such as alopecia areata, congenital alopecia, burn sequelae, eyelash-eyebrow loss, beard loss, and mustache loss. In addition, it can camouflage the scars. The main objective of hair transplantation is to restore hair loss. We may not be able to recreate the appearance that the patients had in their early twenties; however, realistic expectations can be met with the help of technology. Based on our experience, FUE is the method that gives us the opportunity to best meet all patients’ hair transplantation expectations.",signatures:"Safvet Ors",downloadPdfUrl:"/chapter/pdf-download/53490",previewPdfUrl:"/chapter/pdf-preview/53490",authors:[{id:"189369",title:"Dr.",name:"Safvet",surname:"Örs",slug:"safvet-ors",fullName:"Safvet Örs"}],corrections:null},{id:"54527",title:"Complications of Hair Transplantation",doi:"10.5772/66838",slug:"complications-of-hair-transplantation",totalDownloads:2532,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Recently, hair transplantation has been frequently commonly applied for aesthetic surgical procedures. Hair transplantation has a low complication rate compared to other aesthetic surgical procedures. However, it can cause serious complications if proper attention is not given. But there are a wide range of possible complications that are less severe and manageable. Common postoperative complications include pain, edema, asymmetry, bleeding, visible scarring, folliculitis, crusting, graft dislodgement, hiccups, effluvium, pruritus, and hypoesthesia. Other less common postoperative complications include hypertrophic scarring and keloid, arteriovenous fistula, infection, cobblestoning, syncope, pigment alteration, necrosis, granulomatous reaction, pyogenic granuloma, and Kaposi’s varicelliform eruptions. The most serious complication of hair transplantation is necrosis.",signatures:"Murat Küçüktaş",downloadPdfUrl:"/chapter/pdf-download/54527",previewPdfUrl:"/chapter/pdf-preview/54527",authors:[{id:"189869",title:"M.D.",name:"Murat",surname:"Küçüktaş",slug:"murat-kucuktas",fullName:"Murat Küçüktaş"}],corrections:null},{id:"53233",title:"New Modalities in the Treatment of Refractory Alopecia Areata",doi:"10.5772/66591",slug:"new-modalities-in-the-treatment-of-refractory-alopecia-areata",totalDownloads:1928,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Alopecia areata (AA) is a common and complex T-cell–mediated inflammatory disorder. It may be patchy (localized), involve the entire scalp (alopecia totalis) or entire body (alopecia universalis). Alopecia totalis and universalis are often difficult to treat. Although many therapeutic options currently exist in alopecia areata, none of them are curative or preventive. Besides, none of them are approved by Food and Drug Administration (FDA). The disease unfortunately has an unpredictable course. The factors indicating a poor prognosis are the extent of hair loss at the presentation, long duration of the disease, and ophiasis pattern of hair loss. There are only a few randomized controlled studies conducted on recalcitrant AA. Recent research on immunology of hair follicle and recent developments in immunopathogenesis, together with the shared pathways of the disease with other autoimmune disorders, led investigators to focus on novel therapies that target specific immunological pathways. Herein, we will review shortly the current treatment options in recalcitrant alopecia areata based on recently published studies and then will focus on the recently developed broad-spectrum and targeted therapeutics.",signatures:"Arzu Kılıç",downloadPdfUrl:"/chapter/pdf-download/53233",previewPdfUrl:"/chapter/pdf-preview/53233",authors:[{id:"189895",title:"Prof.",name:"Arzu",surname:"Kilic",slug:"arzu-kilic",fullName:"Arzu Kilic"}],corrections:null},{id:"54160",title:"Cosmetic Procedures in the Treatment of Alopecia",doi:"10.5772/66747",slug:"cosmetic-procedures-in-the-treatment-of-alopecia",totalDownloads:3339,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet‐rich plasma, low‐level light therapy, and stem‐cell therapy with variable outcomes are reviewed in this chapter.",signatures:"Selda Pelin Kartal, Cemile Altunel and Bilgen Gencler",downloadPdfUrl:"/chapter/pdf-download/54160",previewPdfUrl:"/chapter/pdf-preview/54160",authors:[{id:"72686",title:"Prof.",name:"Selda Pelin",surname:"Kartal",slug:"selda-pelin-kartal",fullName:"Selda Pelin Kartal"}],corrections:null},{id:"53297",title:"Alternative Medicine for Hair Loss",doi:"10.5772/66593",slug:"alternative-medicine-for-hair-loss",totalDownloads:6430,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In recent years, people have begun to give further emphasis to the external beauty, especially for their hair. Except drugs with proven effectiveness, complementary and alternative treatment options that have not yet been clarified of their effectiveness and side effect profiles have been used for centuries. Many plants or their extracts are widely used to prevent hair loss and treat alopecia (e.g., androgenetic alopecia, alopecia areata, or traction alopecia) worldwide, especially in Far Eastern countries. The mechanisms of action of these plants are still unknown. Although there are little randomized-controlled studies investigating the effectiveness in the treatment of hair loss, reported results have demonstrated that complementary and alternative medicine will become much more popular in the near future.",signatures:"Gurkan Yardimci",downloadPdfUrl:"/chapter/pdf-download/53297",previewPdfUrl:"/chapter/pdf-preview/53297",authors:[{id:"193590",title:"Dr.",name:"Gurkan",surname:"Yardimci",slug:"gurkan-yardimci",fullName:"Gurkan Yardimci"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5941",title:"Fundamentals of Sexually Transmitted Infections",subtitle:null,isOpenForSubmission:!1,hash:"213a3a4ce4fd55711c78e9a7acaf6939",slug:"fundamentals-of-sexually-transmitted-infections",bookSignature:"Server Serdaroglu and Zekayi Kutlubay",coverURL:"https://cdn.intechopen.com/books/images_new/5941.jpg",editedByType:"Edited by",editors:[{id:"64792",title:"Dr.",name:"Zekayi",surname:"Kutlubay",slug:"zekayi-kutlubay",fullName:"Zekayi Kutlubay"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3038",title:"Current Genetics in Dermatology",subtitle:null,isOpenForSubmission:!1,hash:"384a276072f522c3aea68f9d2a0dbfd8",slug:"current-genetics-in-dermatology",bookSignature:"Naoki Oiso",coverURL:"https://cdn.intechopen.com/books/images_new/3038.jpg",editedByType:"Edited by",editors:[{id:"32053",title:"Dr.",name:"Naoki",surname:"Oiso",slug:"naoki-oiso",fullName:"Naoki Oiso"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6961",title:"Alopecia",subtitle:null,isOpenForSubmission:!1,hash:"211055d552abe032133f7281ea2b13dd",slug:"alopecia",bookSignature:"Muhammad Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/6961.jpg",editedByType:"Edited by",editors:[{id:"204257",title:"Dr.",name:"Muhammad",surname:"Ahmad",slug:"muhammad-ahmad",fullName:"Muhammad Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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The book includes information about the genetics of various types of muscular dystrophies as well as explores new and current therapeutic strategies that aim to ameliorate symptoms and improve patients’ quality of life and life expectancy. In addition, this book reviews information on current clinical trials for muscular dystrophies and presents a framework for what to consider during the design of these trials.",isbn:"978-1-83968-475-3",printIsbn:"978-1-83968-474-6",pdfIsbn:"978-1-83968-476-0",doi:"10.5772/intechopen.87261",price:119,priceEur:129,priceUsd:155,slug:"muscular-dystrophy-research-updates-and-therapeutic-strategies",numberOfPages:116,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"dd601de843019d51e1769a26cf7e1acc",bookSignature:"Gisela Gaina",publishedDate:"December 23rd 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9477.jpg",keywords:null,numberOfDownloads:3550,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfDimensionsCitations:2,numberOfTotalCitations:3,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 3rd 2019",dateEndSecondStepPublish:"March 9th 2020",dateEndThirdStepPublish:"May 8th 2020",dateEndFourthStepPublish:"July 27th 2020",dateEndFifthStepPublish:"September 25th 2020",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"242747",title:"Dr.",name:"Gisela",middleName:null,surname:"Gaina",slug:"gisela-gaina",fullName:"Gisela Gaina",profilePictureURL:"https://mts.intechopen.com/storage/users/242747/images/system/242747.jpg",biography:"Florina Gisela Gaina, PhD, currently works at 'Victor Babes” National Institute of Pathology, Bucharest, Romania. She received her PhD in Biology from the University of Bucharest, Romania, in 2009 with a thesis project based on the study of the proteins involved in muscular dystrophies. She is a research scientist working in the field of skeletal muscle. The primary focus of her research activities is on skeletal muscle regeneration. She has been involved in a number of research projects funded by regional, national, and international public agencies. 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The world today is environmentally challenged by the emerging threats of climate change and variability [1]. The IPCC’s Assessment Report 5 has shown the likely climate change impact to have affected greatly agricultural production, particularly in the tropics while enhancing food insecurity and malnutrition in several tropical countries [2, 3]. Tropics, semi-arid and arid regions are considered more vulnerable to climate change effects due to the population nature being exposed to drought and their livelihood source [2]. Furthermore, communities in these regions are largely depending in nature for livelihood, while they are geographically as well socially and economically at disadvantage [4]. Climate change has been affecting agriculture sectors in multiple ways including alteration of agro-ecological zones due to changes in temperature and rainfall, drought stress particularly in areas natured with semi-arid tropics including sub-tropics and flooding [5]. Adaptation strategies for climate change and its associated disasters are crucially important for sustaining the livelihood resilience for communities that are agriculture dependents [6]. Climate change extreme outcomes outlining increases heat and drought during the crops growing season enhances the decline of the top ground biomass and impactful loss of soil nutrients in which impacts largely agricultural production and soil healthy [2]. Adaptation and mitigation strategies differ depending on the local context specifying strategies that are effective to the area regarding the technical, social, natural, financial, physical capital and readiness of the people [6]. In alleviating the severity of climate change impacts adoption of adaptation strategies becomes a core value in agriculture and food production in general [7].
Most rural dwellers depend on agriculture as main the source of economic gains in which the sector is most vulnerable to climate change impacts [7, 8]. Poverty severity among rural dwellers poses difficulties to farmers in such areas in creating resilience to adaptation to climate change impacts [7]. Several adaptation strategies globally have been developed including the growing of new crops adaptive to climate stress, change of sowing time and others [7]. An adaptation to the changing climate impacts the cultivation of pulses globally has been growing and mostly the grown pulses include soybeans, dry pea, lentil and chickpea which are largely and globally grown in semi-arid areas [9]. These pulse crops have been much preferred due to their suitability in responding differently in the growing season’s rainfall and temperature patterns as well pulses tend to increases cereal production when grown in rotation [9]. In several regions pulses have been grown in rotation with maize, wheat and rice while in some areas are intercropped with other crops such as marigold, sunflower, mustard, and coriander [10]. Pulses have been assuring global food security and enhancing the affordable attainment of protein among poor rural societies in which the level of protein contained in chickpea is estimated to be the same as the protein offered by meat [11]. It is globally within the context of climate change; pulses have shown a promising role in meeting world protein demand and food security [12]. Also, when intercropped or rotated, pulses have ensured the attainment of food varieties and increased soil productivity through nitrogen fixation [10]. Chickpea are mostly preferred recently due to their ability of the root trait variability in stress tolerance [11]. FAO has considered prioritizing the production of pulses as among strategies in meeting Sustainable Goal 2 through building resilience in agriculture [11]. Under climate change impacts, pulses particularly chickpea and lentils respond positively as an outcome of fertilization effects due to elevated CO2 related to the lowering of leaf stomata conductance and a decreasing rate of transpiration leading to enhanced water use efficiency [13]. To respond to the impacts of climate change, the adaptation strategies have been developed in different areas including semi-arid areas of Tanzania where one among them is the cultivation of crops which are drought tolerant and those with short maturity period [14]. This study aimed at assessing the rate of pulses specifically chickpea farming adoption as adaptation measures to the impacts of climate change in semi-arid areas.
This study was conducted in Itigi District (Figure 1) found in Singida region, Tanzania. Four villages were involved in the study in which chickpea farming has been a dominant crop farming activity and the villages included Ipande, Damweru, Kitopeni and Itigi. Itigi district is found in coordinates 5°42′ S and 34°5′ E while topographically its altitude above the mean sea level is between 1244 m and 1300 m. Itigi is a semi-arid area experiencing low rainfall and shorty rain season which annually it receives rainfall ranging amount of 500–700 mm and normally experiences one drought season after every four years [15]. The minimum temperature is experienced during the night reaching 15°C while the maximum day temperature being 20°C during the rainy season while during the dry season being 30°C [16]. Sandy soils, grayish brown sands and black cracking soils characterize the soil dominance in the area [6]. Itigi is natured with seasonal streams which normally dry after the rainfall seasons. Based on the last census, Itigi district has a total population of 101,364 people males being 50,801 people and females being 50,563 people which when compared to the consecutive census (2002 and 2012) the population is rapidly growing threatening natural resources including land, water and forest resources found in an area [17, 18]. In terms of vegetation the study area is covered with of thickets famously named as Itigi thickets which are endemic to Itigi covering one-fifth of the total district area and miombo woodland with a variety of miombo species which are in danger due to excessive harvesting [19]. Gypsum deposits in the plains of Itigi offer employment to several dwellers particularly during the dry seasons [20].
Map showing the study villages. Source: AMUCTA Geography Unit.
The study used both quantitative and qualitative methods. Both primary and secondary data were used in the study. One hundred six households were engaged in the study where the sample was attained with the use of Israel sample calculation formulae [21] with the use of a set of prepared structured questionnaires. Two focus group discussions were conducted each having seven members and each included members from two close villages. Key respondents including agricultural officers, village local authorities were engaged through Key Informant Interview while collected information was ensured through transect observation. Data collected were coded in SPSS and analyzed through Chi Square technique to check the relationship between variables at p > 0.05 while the General Linear Model (Univariate Analysis of variance) was used to check the effect of two or more independent variables on one dependent variable.
Assessed socio-economic parameters were sex status of respondents, education level, occupation and age of respondents (Table 1). The study involved both men and women whereby 63.2% were male and 36% were females which reflect the African cultural families that mostly are headed by men. The education level of respondents was as well reflective of African rural areas’ situation in which most respondents had primary education (66%) followed by those who have not attended formal education (26.4%). The study involved more respondents aged above 36 years (74.5%) as are the ones matured enough to recall changes and variations of the climate in the study area and among them 24.5% were aged above 60 years who could easily assimilate the current climatic condition about agricultural activities compared to the past decades. 97% of respondents depend only on agriculture (crop farming and livestock) as a source of income and livelihood while only 3% are employed as local government authorities and other government sectors. During the dry season normally most of the people living in these villages are engaged in small-scale gypsum mining in which is normally becomes a main source of livelihood during the dry season.
Category | Frequency | Percentage (%) | |
---|---|---|---|
Gender | Male | 67 | 63.2 |
Female | 39 | 36.8 | |
Age | 18–35 | 27 | 25.5 |
36–60 | 53 | 50 | |
60+ | 26 | 24.5 | |
Education | Informal education | 28 | 26.4 |
Primary education | 70 | 66 | |
Secondary education | 7 | 6.9 | |
Higher learning | 1 | 0.9 |
Socio-economic characteristics of respondents.
Several farming systems exist in the study villages where 61.3% of respondents are practicing crop farming while agro-pastoralism is practiced by 37.7% of respondents and agroforestry is practiced by 0.9% of respondents. Both cash crops and food crops including cereal and pulses (Table 2) are grown in the study area including cereals, root crops, pulses and oilseed crops. Cereals grown include maize and millet/sorghum while sunflower and groundnuts are the grown oil seeds and nuts. On the side of pulses include chickpea, beans, cowpeas and lentils. Maize is grown as the main source of food for farmers and the community around while sunflowers, chickpeas and lentils are grown as cash crops for commercial purposes.
Category | Frequency | Percentage (%) | |
---|---|---|---|
Crops are grown in the study villages | Cereal crops | 59 | 55.7 |
pulses | 47 | 44.3 | |
Both cereal and pulses | 59 | 55.7 | |
Farming systems existing in the study village | Crop farming | 65 | 61.3 |
Agro pastoralism | 40 | 37.7 | |
Agroforestry | 1 | 0.9 |
Farming systems and crops are grown in the study area.
In the four study villages (i.e., Itigi, Ipande, Damweru and Kitopeni), farmers have changed the type of crops particularly cereals they have been growing in the previous 10 years to grow cereal crops while some of them have adopted the farming of pulses in their respective farmland by reducing the farmland they have been using to grow cereal crops or they have expanded their farms (Table 3). Also, root crops particularly cassava, farmers have been declining their production due to their destruction imposed by wild animals particularly pigs and elephants which are suspected to be from the nearby game reserve.
Abandoned crops to adopt pulses farming | Adopted pulses | ||||
---|---|---|---|---|---|
Crops | Frequency | % | Crops | Frequency | % |
Millet/sorghum and maize | 48 | 45.3 | Chickpea and lentils | 106 | 100 |
Cassava | 64 | 60 | |||
Cotton | 106 | 100 |
Changed and adopted crops in the study villages.
The study identified impact of climate change has been a great driver to farmers in abandoning the growth of cereal crops and adoption of the growth of pulses particularly chickpea and lentils in which chickpea has gained more potentiality among the farmers due to its adaptive nature to drought. 100% of respondents agreed to have experienced impacts of climate change in their areas including change of rainfall reasons, increased drought and increased temperature as well as reduced raining season. 90.6% of respondents claimed the rainfall season to have changed while the remaining percentage (9.4%) were not aware of this shifting season in which the awareness on the changing of climate season was influenced by the age of respondents (X2 = 24.358, df = 4, p = 0.000) whereby all the respondents claimed to have low awareness of the shifting rainfall season were aged between 18 and 30 years old. Formerly the rainfall season was starting in midst of November ending in the early of May but currently, the rainy season begins at the end of December ending at the end of March and in a few years early April.
The period of drought has extended as formerly it was from the late of May to early November while currently it starts from early of April to the midst of December. Also, the occurrence of insect pests was mostly noticed in which was more distractive to crops during the sunny days and when raining no insects were noticed. The trend of insect pest is increasing from year to year and the cereals particularly maize yield loss are more occurring due to these insects mostly armyworms and earwigs in which from 2015 to 2018 cereals production was rapidly declining due to farm crops attach caused by such pest insects. Increasing of temperature is currently experienced during the day and longer than the intensity experienced formerly. Few existing seasonal streams and dams are observed to dry earlier contrary to the formers decades in which they used to last to at least few days after the end of the rainfall season.
The impacts of climate change have significant contribution in the change and adoption of crops grown in the study area (see Table 2). 65.1% of respondents claimed to have changed/adopted the farming of pulses due to climate change impacts. Change of rainfall pattern has caused a loss of cereal crop yields for about 45.3% while increased drought is accounted for the loss of 47.2% of cereal crop yields. Shifting of rainfall season has a significant relationship with the declining of cereal crop production, F (1, 99) = 27.710, p = 0.001. Also, the drought caused a significant decline in the cereal production F (1, 99) = 21.721, p = 0.041. The interaction of shifting rainfall season and increased drought has significantly caused a loss of cereal crop yields, F (1, 99) = 198.770, p = 0.000.
The pulses that are mostly cultivated in the study area due to climate change are chickpea and lentils. Chickpea is grown by 100% of respondents. Statistically, the increase of drought has a significant relationship with the adoption of pulses farming in the study villages X2 = 106.000, df = 3, p = 0.000 and the shifting of rainfall season was found significantly to have caused the adoption of pulses farming in the study X2 = 9.138, df = 2, p = 0.01.
Pulses in the study areas have become the main sources of income among community members in the study areas. Farmers have been selling chickpea and lentils to attain other basic needs. Income generated through chickpea has been used to buy enough food adequate to meet the demands of the household annually. Currently, most of the farmers are living in more improved houses (housed built with bricks) compared to formerly used huts. The income is as well used to send children to schools and in attaining their basic needs such as clothes and getting medical services in case of. Though few, some of the farmers are using income, generated through pulses farming to buy motorcycles, tractors for farming and cows for pulling plough.
Although pulses seem to be alternative crops for semi-arid agriculture under climate change threats, still there are some challenges particularly in the study areas are posing difficulties to attain improvements in pulse crops production. Inaccessibility of improved seeds and lack of awareness of existing improved chickpea and lentil seeds among farmers has been a huge setback in which none of the farmers were found aware of the existence of improved varieties of seeds particularly of chickpea and lentils; therefore, all farmers in the villages are still using traditional seeds and seeds infected by bruchids.
Existing pests in the study area affecting chickpea including Rhizoctonia bataticola (dry root rot), Helicoverpa armigera (Gram pod borer) and collosobruchus chinensis (Bruchids) in which 95% of respondents identified such pests to cause a significant loss of their crop yields. These insect pests seem less responsive to numerous insecticides and pesticides used by farmers in these semi-arid areas. Poor storage facilities favour the harvest and seeds attach by bruchids (Collosobruchus chinensis) which lead to the great loss of harvests in the study villages. 93.6% of respondents claimed seeds loss due to bruchids attaches to their local storage facilities. Furthermore, seeds affected by bruchids are always observed to have been easily attached by other insects and diseases due to soil pathogens particularly when rotated with cereals consecutively in the same farming season.
The crops particularly chickpea and lentils are not included as among crops given first in national policy therefore farmers are not getting agricultural subsidies making difficulties in meeting financial demands for growing chickpea and lentils crops. Among others, minimal agricultural extension services, use of poor farming tools mostly hand hoes for cultivation due to lack of mechanization and a low level of agricultural awareness among farmers still pulls down the efforts of farmers in increasing pulses yields in their farmlands.
Poor farmers’ perception of the fertility level of the soil where pulses are grown affects much pulses production. Pulses particularly chickpea is normally grown in vertisols (dark clay soil) in the all study villages which has a low level of phosphorous in which farmers perceive that the vertisols is always fertile as having a dark color making none of the farmers apply fertilizer in their farms but contrary to the demand of the crop which does well when the soil has a high level of phosphorous. Therefore, despite the ability of the pulses in nitrogen fixation, a low level of other soil nutrients among phosphorus and calcium limits the production of pulses in the study areas.
Climate change effects including drought, low rainfall, shifting of rainfall season and the increasing temperature still affects greatly agricultural production in terms of quality and quantity in several agro-ecological zones greatly in semi-arid and arid regions. These incidences have been leading to food insecurity and the dangers of malnutrition among rural communities in semi-arid areas. Several adaptation strategies have been developed including local ones and modernized ones such as climate and soil friendly agronomic activities, use of improved seeds and cultivation of short-season crops and drought adoptive crops. Farming of pulses and in particular chickpea is found effective to reduce the impacts of climate change effects particularly in semi-arid areas. This is due to the crop’s ability to sustain the harsh climatic condition including drought and shortened rainfall season. Currently improving the adaptive behavior of the crop to resist the effects of increased insect pests as an outcome of climate change is very vital as will enhance crop productivity, ensure farmers availability of food security and nutrition, as well increase farmers household income in semi-arid regions in which its dwellers are more vulnerable to climate change impacts. More studies are needed particularly on insecticides and pesticides which are suitable for such localities. Improvement of other agricultural services including training farmers on better agronomic practices that are climate and soil friendly in attaining sustainable pulses production and soil productivity under climate change particularly in those arid areas and semi-arid areas.
The author wishes to thank all who were very cooperative in carrying this work. Community members in the study villages, agricultural officers and local authorities are highly appreciated for their due contribution in the completion of this work. Specially, appreciation and acknowledgement to District Agricultural officers and Professor Amos Enock Majule of Institute of Resources Assessment (University of Dar es Salaam) for their technical support in carrying this study.
The author wishes to declare no conflict of interest to report.
Cancer is one of the leading causes of death in developed countries including Japan. According to the Japanese Cancer Institute registry data, 1,017,200 patients were estimated to be newly diagnosed with cancer, and 380,300 patients were estimated to die from cancer in 2019 [1]. Colon cancer is the most often diagnosed in Japanese people, followed by gastric and lung cancer. Lung cancer most often causes death related to cancer, followed by colon and gastric cancer. Approximately half of Japanese people suffer from cancer during their lifetime, and one-third die from cancer. Venous thromboembolism (VTE) is a common and serious complication in patients with cancer. The risk of VTE in cancer patients is severalfold higher than that in individuals without cancer [2, 3], and VTE is the second leading cause of death in cancer patients undergoing chemotherapy after death directly related to cancer [4]. Therefore, it is important to prevent and treat cancer-associated VTE to improve prognosis of cancer.
French physician Armand Trousseau first described the relationship between cancer and thrombosis when he reported multiple cancer patients complicated with “phlegmasia alba dolens” caused by deep vein thrombosis in 1865 [5]. He speculated that excess of fibrin and hypercoagulable state of blood caused thrombosis in these patients. Two years later, he suffered from “phlegmasia alba dolens,” and he died from gastric cancer. Since then, many studies have revealed the relationships between cancer and thrombosis. Presently, it is well known that thrombosis, i.e., venous thromboembolism (VTE), arterial thrombosis, disseminated intravascular coagulation, and thrombotic microangiopathy, often occurs in cancer patients, and thrombosis occurring in cancer patients become to be recognized as cancer-associated thrombosis (CAT) (Table 1).
Cancer-associated thrombosis.
Among CAT, VTE most often occurs in cancer patients. VTE is a disease that includes deep vein thrombosis (DVT), which usually occurs in the lower legs, and pulmonary embolisms (PE). Most isolated distal DVTs do not extend to the proximal veins and remain uneventful, whereas parts of clot may break off from proximal DVTs and they may cause potentially life-threatening PE. VTE is the third frequent cardiovascular diseases in Western countries next to myocardial infarction and stroke, and it is estimated that annual incidence of VTE is 1–2 per 1000 adults in the USA [6]. Racial differences may exist in the incidence of VTE, and it is reported that the incidence of VTE in whites is five times higher than that in Asians [7]. Previously, the incidence of VTE in Japanese population was supposed to be low, but more Japanese patients have been diagnosed with VTE, recently. The number of patients diagnosed with PE was 28 per 1,000,000 people in 1996, and it increased to 126 in 2011 [8].
There are several risk factors that induce VTE, and cancer is one of the main risk factors for VTE (Table 2). It has been reported that cancer is associated with 18% of all VTE, and the overall risk of VTE was increased sevenfold in patients with a malignancy (odds ratio [OR], 6.7; 95% confidence interval [CI], 5.2–8.6) vs. persons without malignancy [9].
Risk factors for venous thromboembolism.
Incidence rates of VTE increase with age in the general population. Likewise, cancer-associated VTE occurs more often in the elderly population than younger population. Khorana et al. reported that age 65 or older is an independent risk factor for developing cancer-associated VTE. Cancer-associated VTE is more common in female sex and black race [3]. Obesity; complications such as respiratory disease, kidney disease, and infection; and poor performance status are also risk factors for cancer-associated VTE [10, 11, 12].
The risk of VTE varies by cancer site, and meta-analysis of several studies proves that the incidence of VTE is highest in the pancreatic cancer patients, followed by hematological malignancy and brain tumor patients [13]. VTE more often occurs in patients with advanced cancer than in patients with early cancer [14]. The incidence of VTE also varies by cancer histology, is higher in lung adenocarcinoma patients than in lung squamous cell carcinoma patients [15], and is higher in high-grade lymphoma patients than in low-grade lymphoma patients [16, 17].
Cancer treatment also affects VTE incidence. VTE is a common complication of surgery, regardless of whether it is cancer surgery or not, and adequate prophylaxis is recommended in guidelines including Japanese guideline [18]. However, among cancer patients who received adequate VTE prophylaxis after surgery, 2.1% of them developed massive VTE and 0.8% of them died [19]. Many types of anticancer drugs, such as cisplatin, l-asparaginase, and bevacizumab, also increase risk of thrombosis in cancer patients. Especially, the incidence of VTE is very high in multiple myeloma patients receiving immunomodulatory drugs (e.g., thalidomide, lenalidomide, and pomalidomide), and these patients need primary prevention of VTE by using antithrombotic drugs. Cancer patients often need indwelling central venous catheter (CVC) for delivery of intravenous drugs, parenteral nutrition, and collecting blood samples. Indwelling CVC increases risk of developing VTE, and it is estimated that the risk of symptomatic catheter thrombosis is 0.3–28% [20].
Considering these factors, several risk models to predict the occurrence of cancer-associated VTE have been published. Khorana score is the most widely used risk model among them [21]. Five predictive variables are identified in this score: site of cancer (2 points for very high-risk site, 1 point for high-risk site), platelet count of 350 × 109/L or more, hemoglobin less than 100 g/L (10 g/dL) and/or the use of erythropoiesis-stimulating agents, leukocyte count more than 11 × 109/L, and body mass index of 35 kg/m2 or more (1 point each). Rates of VTE have been reported to be 0.3% in low-risk (score = 0), 2% in intermediate-risk (score = 1–2), and 6.7% in high-risk (score ≥ 3) category over a median of 2.5 months.
Stasis of blood flow, hypercoagulability, and endothelial injury are known as Virchow’s triad, and they are involved in thrombus formation. Stasis of blood flow caused by several factors, such as poor performance status, indwelling CVC, and venous compression by tumor, is thought to be involved in the pathogenesis of VTE in cancer patients.
Blood cells also play an important role in the occurrence of VTE in cancer patients. Leukocyte count 11 × 109/L or above is a risk factor of VTE in cancer patients [21]. Increased leukocyte is found in 20–30% of cancer patients, and it is common in colon and lung cancer patients. Increased expression of granulocyte colony stimulating factor, granulocyte-macrophage colony stimulating factor, and interleukin-6 causes leukocyte increase in cancer patients [22, 23]. Neutrophils may enhance thrombosis through formation of neutrophil extracellular traps (NETs), which take in erythrocytes and platelets, and bind to tissue factor (TF) resulting in activation of coagulation [24, 25]. Increased incidences of VTE are reported both in cancer patients with thrombocytosis prior to cancer diagnosis and thrombocytosis at cancer diagnosis [11, 26, 27]. Higher expression of platelet factor 4, which activates platelets, in cancer patients may be related to the development of VTE [28, 29]. Platelets also play a regulatory role in NETs formation. These may play an important role in the pathogenesis of cancer-associated VTE.
Some proteins also have been reported to be involved in the pathogenesis of cancer-associated VTE. TF plays an important role in hemostasis and activates factor IX and factor X to initiate extrinsic coagulation pathway by forming a complex with factor VII or activated factor VII. VTE most frequently occurs in pancreatic cancer patients, and pancreatic cancer expresses TF. Expression levels of TF correlate with histologic grades of cancer, and the incidence of VTE is higher in patients with pancreatic cancer with high TF expression level [30, 31]. Podoplanin is a protein which activates platelets by binding to platelet C-type lectin receptor 2 (CLEC-2) [32, 33]. The relationships between podoplanin and VTE are proven in patients with glioblastoma multiforme (GBM). Expression levels of podoplanin vary by GBM subtype. GBM with high podoplanin expression level has a high number of platelet aggregates in tumor vessels and is reported to have high incidence of VTE [34].
P-selectin is a protein that exists in platelets and endothelial cells, and soluble form of P-selectin exists in plasma. P-selectin induces leukocytes to damaged endothelium for thrombus formation. The incidence of VTE is reported to be higher in cancer patients with high levels of soluble P-selectin [35]. Inhibition of P-selectin reduces thrombus formation in animal models [36].
Plasminogen activator inhibitor-1 (PAI-1) inhibits plasmin, which is synthesized from plasminogen to dissolve thrombus. Increased level of PAI-1 causes thrombotic tendency. The incidence of VTE is high in pancreatic cancer patients with increased levels of PAI-1 [37]. It is reported that administration of bevacizumab to mice transplanted with lung cancer cells increases PAI-1 expression and enlarges the size of thrombus. Administration of PAI-1 inhibitor to these mice decreases the thrombus size [38]. These findings suggest that increased PAI-1 may be related to the occurrence of cancer-associated VTE (Figure 1).
Pathogenesis of cancer-associated venous thromboembolism. Cancer cells express and release various proteins. These induce leukocytosis and thrombocytosis and activate coagulation resulting in thrombus formation.
Considering the pathogenesis of cancer-associated VTE described in the previous section, it is unlikely that certain diets and nutrition can suppress the development of cancer-associated VTE specifically. Then, are there any diets and nutrition which may prevent the development of VTE in general, not just cancer-associated? The association between diet and nutrition and thrombosis has not necessarily been well analyzed for VTE, but it has been well analyzed for arterial thrombosis such as ischemic heart disease or cerebral infarction. In 2010, the American College of Cardiology announced seven lifestyles to reduce deaths caused by cardiovascular and cerebral infarction by 20% by 2020: (1) nonsmoking, (2) body mass index <25 kg/m2, (3) physical activity at goal levels, (4) pursuit of a diet consistent with the current guideline recommendations, (5) untreated total cholesterol <200 mg/dL, (6) untreated blood pressure < 120/<80 mm Hg, and (7) fasting blood glucose <100 mg/dL [39]. Do these lifestyles also reduce the incidence of VTE? Hypertension, hypercholesterolemia, diabetes (these are related to diet and nutrition), and smoking are risk factors for atherosclerotic cardiovascular disease, and meta-analysis of nine clinical trials revealed that only smoking is a risk factor for VTE among them [40]. These results suggest that diets and nutrition to prevent arterial thrombosis are not necessarily effective for VTE prevention. On the other hand, obesity, one of the risk factors for arterial thrombosis, is also known to be one of the risk factors for the development of VTE. Analysis of the association between 95 BMI-related gene polymorphisms and VTE development proves that five of the polymorphisms are associated with VTE development [41]. Therefore, taking a diet without too much calories or carbohydrates to maintain proper body weight is considered to be useful for VTE prevention.
Other reports examining the relationship between diet and nutrition and VTE are as follow. The incidence of VTE is 22% lower for those who eat fish three or more times a week than for those who eat twice or less a week [42] and is low for those who eat enough fish, vegetables, and fruits and eat less red meat and processed meat [43]. These reports suggest that diets to prevent arterial thrombosis might also be useful to prevent VTE. Furthermore, consumption of grape suppresses thrombin generation and enhances fibrinolysis [44]. Diets with 20, 30, and 50% of their calories on protein, lipids, and carbohydrates for 12 months result in reduction of abdominal circumference, increased HDL-C, decreased fibrinogen, and significantly increased interleukin-10 in those with metabolic syndrome [45]. These reports suggest that diet and nutrition might directly affect the blood coagulation and fibrinolysis which play an important role in the development of VTE.
Several reports related to the alcohol consumption and VTE have also been published. Women consuming alcohol daily were at 26% lower risk of VTE than non-consumers [46], and the analysis of three large US cohorts showed no evidence of an association of alcohol consumption amount or frequency with PE risk [47]. These findings suggest that alcohol drinking is not a risk factor for VTE.
The accumulation of various genetic abnormalities in normal cells causes carcinogenesis. Some cancers are caused by congenital genetic abnormalities, but most genetic abnormalities causing cancers are acquired abnormalities. It is estimated that smoking contributes to 20% of cancers and 23% of cancer deaths and infection with helicobacter pylori, hepatitis virus, etc. contributes to 21% of cancers and 22% of cancer deaths in Japanese population, and these are thought to be the main risk factors for cancer in Japanese population. Drinking alcohol contributes to 6% of both cancers and cancer deaths, and it is also a significant risk factor for cancer in Japanese population. Consumption of salt more than 6 g per day, deficiency of fruit intake, and deficiency of vegetable intake also contribute to 1.6, 0.7, and 0.6% of cancers and 1.4, 0.8, and 0.6% of cancer deaths, respectively [48]. Diet and nutrition seem to have some effects on the development of cancer and cancer mortality.
According to a report “Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective” published by World Cancer Research Fund and American Institute for Cancer Research, it is convincing that adult body fatness has increased risks of esophageal, pancreatic, liver, colorectal, postmenopausal breast, endometrial, and kidney cancer. As for diets and nutrition, there exist causal relationships between aflatoxin and liver cancer, lean and processed meat and colon cancer, arsenic in drinking water and lung cancer, and high-dose beta-carotene supplements and lung cancer. On the other hand, whole grains and food containing dietary fiber decrease colorectal cancer. Non-starchy vegetables and fruits decrease aerodigestive cancer and some other cancers [49]. It is not fully understood how each diet and nutrition has effects on carcinogenesis, a diet with enough vegetables and fruits, less lean and processed meat, reduced carbohydrate and fat to prevent obesity, and low in salt might be useful to reduce cancer incidence.
In 2017, the American Society of Clinical Oncology announced that alcohol drinking had been established as a risk factor for cancer, and avoiding excessive drinking was important to prevent cancer [50]. The development of pharyngeal, laryngeal, esophageal, liver, breast, and colorectal cancer was obviously related to alcohol drinking. The incidence of esophageal cancer was 1.3 times higher for small drinkers, 2.2 times for moderate drinkers, and 5 times for heavy drinkers than non-drinkers. Ethanol itself is not carcinogenic, but acetaldehyde, its metabolite, binds to DNA and proteins to be carcinogenic and mutagenic. It is proven that administration of large amount of ethanol or acetaldehyde causes cancer in animal experiments [51]. Acetaldehyde is metabolized by aldehyde dehydrogenase 2 (ALDH2). Higher percentage of Japanese people has inactive form of ALDH2 compared to the Western. It might result in adverse effects of alcohol drinking on carcinogenesis in Japanese population.
Smoking is a well-known risk factor for cancer. The International Agency for Research on Cancer (IRAC) assessed causal relationships in 2009 and stated that smoking is related to oral, pharyngeal, laryngeal, esophageal, lung, gastric, colon, liver, pancreatic, renal cell, renal pelvis, ureter, bladder, cervical, and ovarian cancer and chronic myelogenous leukemia. Passive smoking is a risk factor for lung cancer [52]. To prevent cancer of yourself, your family, and your colleagues, no smoking is mandatory (Figure 2).
Effects of diets and lifestyle on cancer and venous thromboembolism (VTE). Fish, vegetables, and fruits may decrease the incidences of both cancer and VTE. Cigarette smoking and obesity increase the incidences of both cancer and VTE. Drinking alcohol and consuming lean and processed meat increase the incidence of cancer. Whole grain and dietary fiber decrease the incidence of cancer.
Aspirin is a widely used antiplatelet drug that inhibits platelets’ cyclooxygenase (COX), resulting in decreased platelet aggregation. Numerous studies have demonstrated the effects of aspirin on the secondary prevention of arterial thrombosis, and several studies have investigated the effects of aspirin use for the primary prevention of atherosclerotic diseases. Meta-analyses of these studies have shown that daily regular aspirin use reduce the incidence of colon cancer, mortality of colon cancer, and metastasis of colon cancer. The incidence or mortality of other types of cancer might also be reduced [53, 54, 55]. Increased COX expression results in tumor growth and progression, and inhibition of COX reduces carcinogenesis in animal experiments. Platelets are known to play an important role in tumor metastasis [56]. These might be related to the inhibitory effects of aspirin on cancer reported in meta-analyses. On the other hand, some recent reports have shown that regular aspirin use does not decrease cancer incidence or cancer mortality [57, 58, 59] (Table 3). Further studies are needed to confirm the effects of aspirin on cancer incidence and cancer mortality.
Effects of aspirin on cancer incidence and cancer mortality.
Various factors are involved in carcinogenesis and occurrence of cancer-associated VTE. Certain diets and nutrition may reduce the risk of VTE. Some lifestyles may reduce cancer incidence, and other lifestyles increase the risk of cancer. Further studies are needed to create ideal diet, nutrition, and lifestyle to reduce the risk of cancer and cancer-associated VTE.
The author declares no conflict of interest.
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Polymorphism at the DNA level includes a wide range of variations from single base pair change, many base pairs, and repeated sequences. Genomic variability can be present in many forms, including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs, e.g., mini- and microsatellites), transposable elements (e.g., Alu repeats), structural alterations, and copy number variations. Different forms of DNA polymorphisms can be tracked using a variety of techniques; some of these techniques include restriction fragment length polymorphisms (RFLPs) with Southern blots, polymerase chain reactions (PCRs), hybridization techniques using DNA microarray chips, and genome sequencing. During the last years, the recent advance of molecular technologies revealed new discoveries of DNA polymorphisms. DNA polymorphisms are endless, and more discoveries continue at a rapid rate. Mapping the human genome requires a set of genetic markers. DNA polymorphism serves as a genetic marker for its own location in the chromosome; thus, they are convenient for analysis and are often used as in molecular genetic studies.",book:{id:"6719",slug:"genetic-diversity-and-disease-susceptibility",title:"Genetic Diversity and Disease Susceptibility",fullTitle:"Genetic Diversity and Disease Susceptibility"},signatures:"Salwa Teama",authors:[{id:"249329",title:"Dr.",name:"Salwa",middleName:null,surname:"Teama",slug:"salwa-teama",fullName:"Salwa Teama"}]},{id:"58467",title:"Generation of Antibody Diversity",slug:"generation-of-antibody-diversity",totalDownloads:3111,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Because of the huge diversity, the immunoglobulin repertoire cannot be encoded by static genes, which would explode the genomic capacity comprising about 20,000–25,000 human genes. The immunoglobulin repertoire is provided by the process of somatic germ line recombination, which is the only controlled alteration of the genomic DNA after meiosis. It takes place in mammalian B lymphocyte (B cells) precursors in the bone marrow. The genome germ line sequence of undeveloped B cells is organized in gene segments and compromise V (variable), D (diversity), and J (joining) gene segments constituting the variable domain of the heavy chain and only V and J genes for building up the variable domain of the light chain. The rearrangement of the variable region follows a strict order. The following processes that participate in the generation of antibody diversity were summarized—allelic, combinational, and junctional diversity, pairing of IgH and IgL, and receptor editing—which all together produce the primary antigen repertoire (pre-antigen stimulation). When a B cell encounters a foreign antigen, affinity maturation and class switch are induced. Thereby the antibody repertoire increases. The resulting secondary immunoglobulin repertoire reveals in humans at least 1011 specificities for different antigens.",book:{id:"5784",slug:"antibody-engineering",title:"Antibody Engineering",fullTitle:"Antibody Engineering"},signatures:"Oliver Backhaus",authors:[{id:"177685",title:"M.Sc.",name:"Oliver",middleName:null,surname:"Backhaus",slug:"oliver-backhaus",fullName:"Oliver Backhaus"}]},{id:"61204",title:"Polymorphisms",slug:"polymorphisms",totalDownloads:2005,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptible to diseases, and respond to drug, vaccine, chemical, and pathogen. It occurs more often than mutations (frequency ≥ 1%). The common polymorphism is single nucleotide polymorphism (SNP) which is a single base change in a DNA sequence that occurs most commonly in the human genome. SNPs have been used as molecular markers in a wide range of studies. Genome-wide association studies (GWAS) searches for SNPs that occur more frequently in person with a particular disease than in person without the disease and pinpoint genes or regions that may contribute to a risk of disease. 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Modern embryology owes its initial development to the key embryo collections that began in the 19th century. The first large collection was that of Carnegie, and this was followed later by the major 7 collections. The second role of the Carnegie collection was for researchers to establish a defined set of Carnegie stages based on embryo morphological features. Today, embryos are imaged three-dimensionally (3D) by a range of imaging modalities including, magnetic resonance microscopy (MRM), episcopic fluorescence image capture (EFIC), phase-contrast X-ray computed tomography (pCT), and optical projection tomography (OPT). Historically, embryo serial images were reconstructed using wax-plate and model techniques. The above new 3D imaging techniques now allow 3D computer reconstructions, analysis, and even 3D printing. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/79202",hash:"",query:{},params:{id:"79202"},fullPath:"/chapters/79202",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()