\r\n\tIt has been established that energy/nutrient depletion, calcium flux injury, or oxidative stress disrupt endoplasmic reticulum homeostasis and even induce accumulation of misfolded/unfolded proteins leading to endoplasmic reticulum stress. Under endoplasmic reticulum stress conditions, an adaptive mechanism of coordinated signaling pathways, defined unfolded protein response (UPR), is activated to return the endoplasmic reticulum to its healthy functioning state. The aging causes a decrease of the protective adaptive response of the UPR and an increase of the pro-apoptotic pathway together with endoplasmic reticulum ultrastructural injury. Controlling endoplasmic reticulum stress response, maintaining the appropriate endoplasmic reticulum ultrastructure and homeostasis, and retaining mitochondria interplay are crucial aspects for cellular health.
\r\n\r\n\tThis book presents a comprehensive overview of endoplasmic reticulum, including, but not limited to, endoplasmic reticulum ultrastructural anatomy, MAMs, endoplasmic reticulum stress, and their implication in health and diseases. Additionally, identifying perturbations in the endoplasmic reticulum stress response could lead to early detection of age-related disease and may help develop therapeutic approaches.
",isbn:"978-1-80356-228-5",printIsbn:"978-1-80356-227-8",pdfIsbn:"978-1-80356-229-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"5d7d49bd80f53dad3761f78de4a862c6",bookSignature:"Dr. Gaia Favero",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",keywords:"Metabolism, Aging, Neurodegenerative Diseases, Endoplasmic Reticulum, Microscopy, Metabolic Stress, Ultrastructural Anatomy, Cellular Stress, Contactology, Mitochondria, Cellular Stress, Endoplasmic Reticulum Response",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 9th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"19 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Human anatomy researcher involved in crucial topics on morphology, anatomy, and molecular medicine - working on innovative approaches to aging-related pathopsychological processes at the University of Brescia.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"238047",title:"Dr.",name:"Gaia",middleName:null,surname:"Favero",slug:"gaia-favero",fullName:"Gaia Favero",profilePictureURL:"https://mts.intechopen.com/storage/users/238047/images/system/238047.jpg",biography:'Dr. Gaia Favero is a prominent scientist in the field of life sciences. She is currently engaged as a researcher for the Scientific-Disciplinary Sector BIO/16 Human Anatomy at the Anatomy and Pathophysiology Division, Department of Clinical and Experimental Sciences, University of Brescia (Italy).\r\nDr. Favero focuses on aging-related morphological dysfunctions as the prelude to various pathophysiological processes in her research programs. The central hypothesis is that natural antioxidants and, in particular, melatonin may act as molecular "switches" that modulate cells and tissues by suppressing, at various levels, oxidative stress and inflammatory signalling cascades. These research approaches represent powerful tools for developing innovative preventive strategies and identifying novel prognostic biomarkers for several diseases. The above-reported research activity determined more than 120 scientific publications and an h-index of 25.',institutionString:"University of Brescia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Brescia",institutionURL:null,country:{name:"Italy"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"6",title:"Biochemistry, Genetics and Molecular Biology",slug:"biochemistry-genetics-and-molecular-biology"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"278926",firstName:"Ivana",lastName:"Barac",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/278926/images/8058_n.jpg",email:"ivana.b@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6694",title:"New Trends in Ion Exchange Studies",subtitle:null,isOpenForSubmission:!1,hash:"3de8c8b090fd8faa7c11ec5b387c486a",slug:"new-trends-in-ion-exchange-studies",bookSignature:"Selcan Karakuş",coverURL:"https://cdn.intechopen.com/books/images_new/6694.jpg",editedByType:"Edited by",editors:[{id:"206110",title:"Dr.",name:"Selcan",surname:"Karakuş",slug:"selcan-karakus",fullName:"Selcan Karakuş"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"77919",title:"Examining Learning Disabilities in Schools through an Intersectional and Equitable Lens",doi:"10.5772/intechopen.99572",slug:"examining-learning-disabilities-in-schools-through-an-intersectional-and-equitable-lens",body:'1. Introduction
Approximately 150 million students 18 years old and under have a disability label that qualifies them to receive special education services in schools [1]. In the United States, many students from minority groups (e.g., English learners, ethnic-racial minority, low social class) were overrepresented in special education. The primary reason for the overrepresentation is due to the teachers’ lack of cultural knowledge and lack of culturally responsive instruction that is adequate and responsive to their diverse students’ needs [2]. Though the Individual Disabilities Education Improvement Act [3] was established to address supporting students with disabilities in providing adequate education, the disproportionate overrepresentation of students from marginalized groups generate a needed discussion surrounding the inequities present in learning disability (LD) referral and identification.
Teachers’ lack of cultural competence in their instruction leads to a broader issue surrounding culturally responsive instruction that has shown to be effective in responding to the needs of their diverse students [4]. The question arises whether the existence of LD is a result of neurobiological differences that lead to difficulties in learning [5] or social factors [6]. For example, dyslexia is increasingly being debated whether it is a valid difficulty [7]. One can consider the societal implications of being a poor reader or having inadequate mathematics skills. Rather than placing the disability limitation on the individual person’s physical or mental limitation as postulated by the medical model of disability [6], the social model of disability focuses on the environment surrounding the individual, identifying systemic barriers, derogatory attitudes, and social exclusion making it difficult for the individual to function appropriately [6]. From this perspective, one questions the purpose of having a LD label as the basis for decision making in education. As there are multiple approaches to identifying and supporting students with LDs, it is critical to understand, through a social model of disability perspective, how an LD identification can benefit students with LDs.
As there is no “gold standard” to indicate what is or is not considered an LD, the approaches to identifying and supporting students with LDs do not appear to be strongly evidence-based. The social model of disability focuses on understanding how school processes such as LD identification result in inequitable assignments to specific groups of students including racial-ethnic and linguistic minorities, low socioeconomic class, and boys [6, 8]. However, looking at LD through a social lens brings to light further questioning on the issues surrounding LD identification such as the disproportionality of identification based on social circumstances such as intersectional identities of sex, class, and ethnicity. It may be problematic to simply identify and assign the LD label to students based on cognitive measures that may be subjective in nature and influenced by social factors. This book chapter attempts to understand the societal issues surrounding LD identification through an intersectional lens and its implication on education. This book chapter will be contextualized in the North American context (including both United States and Canada) to understand the social factors (e.g., socioeconomic disadvantages, sex differences, and racial and ethnic intersection) as a potential cause for disproportionate representation.
2. Learning disabilities
Learning disability (LD) is a label typically assigned to students based on their achievement levels, behaviors, or communication skills [9]. One federal disability category, ‘Specific Learning Disability’, encompasses all of the various LDs including disabilities like dyslexia (reading disability), dyscalculia (mathematics disability), dysgraphia (writing disability), and expressive language disability [9]. It is important to note that labels such as attention deficit/hyperactivity disorder (ADD/ADHD), autism spectrum disorder (ASD), and Down syndrome are not categorized under ‘Specific Learning Disability’. Though LD is commonly misconstrued as students with low intelligence quotient (IQ ), this can lead to a misperception equating LD with students with poor educational outcomes rather than an inequality in the school environment for students’ learning opportunities [9, 10]. Due to the lack of gold standard in identifying LDs, the different approaches present in identifying LD brings into question what the LD label represents and whether placement into special education benefits students’ learning opportunities.
Around the 2000s, there were three dominant cognitive discrepancy methods to identify LDs: 1) ability-achievement discrepancy model, 2) low-achievement model, and 3) intra-individual discrepancy model [11]. The ability-achievement discrepancy model assigns students the LD label when their achievement levels are lower than expected given their overall IQ . In this model, the discrepancy must not be attributable to the student’s social background or behaviors [12]. The second model, low-achievement model assigns a LD label to students who are unexpectedly performing below a certain achievement level [12]. Lastly, the intra-individual discrepancy model assigns students a LD label if they show an uneven profile, defined as specific cognitive measures indicating strengths in some areas and weakness in others [12]. However, these three models have been criticized for not systematically identifying students who do have an LD as measures of achievement may not accurately assess ability but rather contextualized knowledge that have been shown to benefit White, middle-upper class students in attaining higher scores. As it is shown that LD identification approaches vary and lack a gold standard, many questions the existence of LDs [13].
Two major issues exist in defining and identifying LD. First, LD represents an unobservable latent construct that does not exist apart from its measurements (e.g., IQ , achievement) [14]. Second, there is a level of comorbidity with other developmental disorders that may explain the IQ-achievement gap necessary for a LD identification [14]. As achievement and IQ , both scores that can be understood as inequitable towards non-White, lower-middle class students, are used as a basis for LD identification, it can be construed that LD identification does not simply identify students with LDs (e.g., writing, reading, mathematics) but also the social inequities that are present in students’ lives (e.g., class, sex, class) [9, 10]. One model that has attempted to move beyond simply identifying LDs is Response to Intervention, a model to better account for social factors (e.g., class, sex, class).
3. Response to intervention
Inclusive education (IE) is the idea that education is a basic human right for all students, following the principles of social justice [15]. The World Declaration on Education for All (EFA) defined general principles of IE as providing universal access to schools for everyone and promote equity, being proactive and predicting barriers in access to education and identifying recourses to eliminate such barriers [16]. IE is a process which increases the opportunities and capacity education to meet needs and interests of all learners. In the wake of the United Nations Convention on the Rights of Persons with Disabilities, IE has become increasingly important to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all. One such framework, beyond the three cognitive-discrepancy approaches, is Response to Intervention (RTI). The three cognitive-discrepancy approaches focus on improving students with an IQ-achievement gap. However, there is evidence that the cognitive difficulties associated with LDs parallel the challenges experienced by students who have not received adequate instruction [17], leading to the question whether appropriate instruction is provided such that all students, regardless of the LD label, benefits in an opportunity to learn. This is the emergence of the Response to Intervention (RTI) model.
The RTI model consists of many different components broken down into three tiers. Tier 1 instruction consists of class-wide universal screening, defined as screening assessments to identify students likely to experience poor academic outcomes [18]. Tier 2 instruction involves small-group supplemental programs in addition to Tier 1 instruction with constant assessments conducted to determine whether students are responding to the more intensive Tier 2 instruction [18]. Tier 3 instruction involves individualized program instruction to supplement Tier 1 class-wide instruction [18]. Throughout each tier, progress monitoring is conducted to assess whether students are responding to the Tier 2 or Tier 3 instruction to ensure that the academic outcome gap is decreasing [18]. Though this model moves beyond LD identification for labelling purposes and attempts to support all students, with the focus on reducing the academic gap, the RTI model is still focused on outcomes that are socially influenced. As such, subjectivity may be present inherently by disadvantaging students with certain sociodemographic characteristics towards inequitable academic outcomes.
There have been increasing discussions surrounding a culturally responsive RTI model where RTI focuses on the contextual factors that impact achievement. In this scenario, although achievement is still the focus, RTI takes into consideration cultural factors that impact achievement [19, 20]. For culturally responsive RTI, teachers understand the cultural nature of learning, consider students’ socio-cultural context of schools, and promote equity within school policies, decisions, and pedagogical practices. Therefore, though culturally responsive RTI is increasingly discussed, there appears to be difficulty in incorporating RTI taking into consideration students’ intersectional identities, requiring significant amounts of support [21]. Across all LD identification methods, research has documented inconsistencies across schools, leading to the subjectivity inherent in LD identification and support, producing inequality by disadvantaging youth with certain sociodemographic characteristics [21, 22]. From the understanding of the issues surrounding LD identification across all methods, one questions the educational issues experienced by students with intersectional identities including, of which LDs are one of their social identities.
4. Intersectionality
Intersectionality is an analytical framework to examine how differing identities, such as race, sex, class, and sexuality, and how their combination plays out in different settings [23]. Though intersectionality examines different social identities, much of the literature has not, until recently, included disability to the list of social categories that marginalize individuals. Together, race-ethnicity, gender, disability, and social class are social identities that intersect with one another and result in oppression and discrimination [23].
Though there are increasing number of students who are being identified as having a LD, there appears to be a disproportionate number of LD identification towards students from racial-ethnic minority status, boys, and those who are from a lower socioeconomic status [9, 10]. Data from the National Assessment of Educational Progress (NAEP) suggests such social identities as potential causes for such disproportionate representation [24]. The over-identification of students with intersectional identities that receive special education services (e.g., students from diverse ethnicity and race, class, and sex) leads to question the responsiveness of LD identification approaches and the subjectivity inherent in identifying and labelling LD. The National Center for Learning Disabilities (NCLD) found similar evidence pointing to a higher risk for students of color. Specifically, their data indicated that American Indian/Native, Black/African American, Native Hawaiian/Other, Hispanic/Latinx, and those with more than one race/ethnicity all received special education at a higher identification rate compared to Caucasian students [25]. Interestingly, this was not the case for Asian students [25]. However, existing literature has found that English Language Learners (ELL) are similarly overrepresented as being identified as students with LDs [9, 10, 26]. As such, this poses an interesting intersection of racial-ethnic minority students and students who are learning English, as it is assumed that students who are ELLs can also contain Asian students.
An emerging body of literature has found an over-identification for English Language Learner (ELL) students to receive special education services, highlighting a need for cultural competence and responsiveness [10, 26, 27]. As ELLs and race/ethnicity are closely intertwined in their identities, this book chapter attempts to further examine other intersections between LDs and other identities to understand the diverse experiences of students with LDs and the issues surrounding the disproportionalities that exist in LD identification, and how relevant stakeholders can respond adequately in schools.
5. Educational issues for students with LD
Across the U.S., students with LDs constitute 34% of all students with disabilities, accounting for 4.5% of all students in schools [28]. For students without disabilities, 84% graduate, whereas 65.5% of students with disabilities graduate, indicating a need to further identify the necessary supports for students with LDs [28]. For example, after LD identification, students with LDs receive special education services, including learning in a separate classroom specifically designed for students with disabilities, a concept known as least restrictive environment (LRE) [29]. However, misidentifying students risk them being exposed to a less rigorous curriculum, lower expectations, and fewer opportunities to successfully transition them to postsecondary education [25]. Inappropriate LD identification can also result in social consequences, with students suffering from a loss of self-esteem, being exposed to greater stigma, and facing increased marginalization in classrooms (e.g., racial separation). Once misidentified, students are likely to stay in the special education program for the remainder of their academic trajectory [25].
Through an understanding of the social model of disability, labelling a student with LD is indicative that there are certain barriers in the classroom that is preventing them from performing at the same level compared to their peers without the LD label [6, 8]. Put into different words, students with LD are unfavorably biased against Caucasian middle-class norms of achievement. As labels such as LD are subjectively constructed based on unobservable latent construct of achievement, students with the LD label are perceived as deviating from the average or high IQ/achievement and is simply not receptive to the teaching practices that work for students without LD. In this manner, the LD label can be understood as a tool of inequality due to the lack of positive outcomes of being placed into special education placement.
LD label can also be understood as an intentional tool of inequality. From a social perspective in understanding LDs, LDs can be understood as a social construct that is defined relative to the context and situation, argued to be more prevalent in Western societies due to the emphasis on speed, literacy, and numeracy in the school system [30]. In other words, students labeled with LDs do not experience inequities due to their LD but the society that is structured to benefit students with normative qualities (i.e., Caucasian, middle-class). Due to the lack of objective and uniform diagnostic criteria in identifying LDs, variations across students can be understood as natural, with everyone possessing some level of ‘disability’ in different contexts relative to their peers [13, 30]. Therefore, LD identification can be understood as an inequity due to the societal emphasis on specific Western values (speed, literacy, and numeracy). This questions the validity of the LD identification as an inequitable perception in schools’ responses to students with LDs. Moreover, there is evidence that having the LD label can have social psychological ramifications in their classroom experiences [9]. Below will be an exploration of inequalities experienced across different subgroups of LDs: 1) culture, race, and ethnicity, 2) sex, and 3) social class.
6. Inequalities of culture and LDs
Under a cultural identity, I have chosen to group cultural and linguistic identities together as they go hand in hand for cultures that do not speak English primarily in their country. However, predominant literature on inequities in LD identification have focused on students learning English, also known as English Language Learners (ELLs). Though many studies have focused on culture and LDs through language barriers, broader cultural influences exist that influence the learning of students of color with LDs [10, 31]. For example, teachers expressed a lack of cultural understanding and competence to provide culturally relevant instruction to their culturally diverse students [4, 32].
For students with LDs, there is an increasing number of studies investigating the disproportionalities in LD overidentification. One such group of students are students with racial-ethnic minorities and those who are learning English. For example, African-American students with LDs reported negative consequences of their special education placement [12, 33]. Though they mentioned benefits of special education placement such as interactions with responsive teachers and more appropriate instructional pacing, the social consequences of having a LD label outweighed such benefits. They reported additional stigmatization by peers (in addition to their race-based harassment) [34], making limited academic progress due to a slow-paced curriculum, and barriers preventing them from returning to general education placements [33].
Much of the literature surrounding culture, race, and ethnicity disproportionalities involve students who do not primarily speak English. In the intersection between language and LD, the disproportionate labeling can be attributable to the flawed methods of LD identification (i.e., IQ and achievement) as cognitive ability measurements do not distinguish whether their lack of ability is due to their linguistic or learning ability [35]. As NCLD data [25] has shown that only 33% of students of color (i.e., Black) spend more than 80% of their day in general education classroom, compared to 55% of Caucasian students, the disproportionate placement of students of color into special education can be attributed to systemic racism inherent in the education system, considering the subjective nature of the LD identification procedures as well as the inadequate instruction to foster responsive learning opportunities for all students, including students of color.
In addition to students of color experiencing a disproportionate amount of LD identification perhaps due to the lack of responsive instruction or subjective nature of LD identification, language barriers exist for students who may have language barriers, commonly from students from culturally and linguistically diverse backgrounds. The subjectivity in being able to tell whether students have a LD or whether the lack of ability is due to their language restrictions leads to subjective labeling of LD for students and whether the purpose of LD identification is valid. Evidence has shown that students who are both ELLs and identified as having a LD are placed at an increased risk for school failure than students in either group (ELLs or LDs), due to their barrier in participating in general education classes [36]. Therefore, the disproportionality of having students who may have language barriers rather than a learning barrier can pose more academic risk than providing special education support. With this in mind, it is unclear whether there is a benefit in a LD identification, particularly due to the subjective nature of LD identification and an understanding of whether appropriate instruction can remedy this language or learning gap.
7. Inequality of sex and LDs
Much of the research surrounding disproportionality and sex differences found an over-identification of LDs among boys. Previous research exploring sex differences among students with LD found girls being 1.5 to 6 times less likely to be identified as having a LD compared to boys [10, 37]. The differences in LD identification between boys and girls is attributed to the referral bias, a step prior to LD identification. From this bias, this brings up another issue with the LD identification process and the subjective nature biased against students not from the dominant culture (i.e., Caucasian, middle-class). There appears to have a tendency where boys are referred to special education services for LD more than girls, leading to inequity for all students, over-identification for boys and under-identification for girls. This over-identification of LD identification among boys was due to the problematic behaviors (e.g., impulsivity, hyperactivity, disruptiveness) in class. Similarly, a reason for under-identification of LDs among girls was due to a lower sign of ‘objective’ behaviors as a reason for referral to special services. Another possibility, from a social perspective, is the different social expectations expected by boys and girls, such that society sets higher standards of achievement for boys than girls [10, 37]. The subjectivity in referral for special education services due in part to the lack of gold standard for LD referral and identification, leads to inaccurate identification of LDs in students, and creates increased social psychological risks and lowered academic expectations for both boys and girls.
8. Inequalities of class and LDs
Another source of inequality is the occurrence of LDs among students due to social class. Students with LDs were found to have similar behaviors and academic outcomes compared to students from a lower socioeconomic class [10, 38]. Students from such social backgrounds attributed achievement gaps to prenatal factors, malnutrition, parenting style differences, and deprivation of sensory and stimulating environments [10]. Historical and contemporary evidence suggests that the achievement gap used to identify LDs among students can be explained in part due to students’ lower social class and being economically disadvantaged compared to their peers [10]. In this sense, the LD label, then, is used to explain lower achievement as a result of incompetent parents and low social position, all social factors that are systemic and out of the control in being able to support the students.
Students who develop in lower socioeconomic environments are exposed to reduced linguistic input in the home environment and can be behind in their language development when they enter school, which subsequently can interfere with their reading and numeracy skills [39]. Evidence has shown that early interventions targeting reading, writing, and numeracy skills remedied the achievement gap typically found in students from a lower socioeconomic class [1, 40]. Therefore, from this social perspective, the achievement gap experienced by students who are from lower socioeconomic class that are considered to have a LD can be understood as societal inequities due to lack of opportunities and resources in developing their reading, numeracy, and writing skills. If the mechanisms of students with LD are in fact having achievement gaps due to a lack of opportunities and resources in their lower socioeconomic home environment, then this calls into question the need for teachers to provide adequate and responsive support for their diverse students who may lack the resources in their home environment.
9. Intersectional identities in LD identification
In United States, there is a history of racism and persisting racial stratification that leads students of color to have less educated parents, lower levels of family income, and decreased access towards resources in the dominant culture (i.e., Caucasian culture) [41]. In this manner, students of color experience increased risks due to their lower class, including cardiovascular disease, arthritis, diabetes, and mental illness, all of which disproportionately diagnose them as having LD, though the achievement gap may not be due to a lack of learning ability but societal influences [10, 41]. Similar achievement gaps and disproportionality was found from Canadian data [42]. There is some burgeoning literature that have begin to find intersectional relationships, such as between culture and class disadvantage, being a key contributor to heightened risk in being misidentified as having a LD.
With an understanding of the inequities faced by students who are ethnically-racially diverse, of lower socioeconomic class, and both boys (over-identification) and girls (under-identification), there are several studies that have begun to look at the intersections of several of the aforementioned identities. However, studies examining intersections of students with LDs and their identities appear to be primarily focused on cultural and linguistic diverse (CLD) students commonly tied with their lower social class [10, 26]. Evidence continues to show that students coming from a lower social class and are an ethnic-racial minority are more likely to be identified as having a LD compared to Caucasian students from middle-to-higher social class [9, 43]. For example, students who are learning English can have decreased achievement scores, not due to difficulties in their learning but their linguistic barriers preventing them from accurately responding to assessment [26]. Both academic and social-psychological outcomes vary according to students’ intersectional identities (i.e., ethnic-racial, linguistic, socioeconomic, sex, disability) [44].
As discussed above, each group of students experience risks associated with inequitable LD referral and identification, due to the achievement gaps used as a method of diagnosis in the three cognitive models. However, culture, language, social class, and sex were all identities and groups shown to experience inappropriate LD referral and identification. This can be understood as a reflection of the inequitable access to effective and responsive educational practices along with complex and societal inequities (i.e., achievement gap, LD identification) and biased perceptions from the teacher (i.e., LD referral) [10, 40]. Particularly as students of color are more prevalent in the lower social class [45], they are at a higher risk for being identified as having a LD, whereas such students may simply require appropriate and responsive instruction by the teacher. This risk would be even more heightened for boys (or students who exhibit more problematic behaviors in classrooms) due to their excessive referrals for LD identification [10, 37].
Though students who are learning English are a heterogeneous population in terms of sociocultural background, the lack of precision in LD identification to discriminate between neurobiological deficits and societal barriers leads to learning difficulties or systemic barriers and inequities that result in decreased achievement scores [10, 13, 26]. In addition to misidentification of LDs based on inaccurate achievement scores as a result of language and systemic barriers (e.g., socioeconomic disadvantaged environments), another layer of inequity is the biased referral towards both male and female students. The subjective referral for special education services based on problematic behaviors predominantly exhibited by male students poses an additional layer of inequity. Though LD referral and identification may be beneficial for some students to be qualified for additional support, the over-identification of male students and under-identification of female students for special education services call attention to social inequities that prevent students from appropriate learning opportunities. At the intersection of sex, one questions whether biased referrals similarly persist when taking into account diverse gender identities as biased LD referrals were based in problematic behaviors.
This leads to questions surrounding the purpose of LD identification and its intended nature. Should schools want to support students from diverse cultural, ethnic-racial, and social class backgrounds, rather than understanding the identification process of LDs in students that bar students from accessing additional educational support, a culturally responsive RTI model can be a model for teachers to provide effective and responsive instruction that supports all diverse students.
10. Moving forward
As our contemporary society is increasingly responsive to our diverse students’ needs and identities, it is critical to understand how the educational system is supporting diverse students. Though LD identification allows for access to special education services, evidence shows risks associated with LD identification, such as lowered academic expectations, peer stigmatization due to special education placement (in addition to pre-existing stigmatization as a result of ethnic-racial minority identities), and lowered self-esteem among other social–emotional outcomes [10, 43, 46]. Based on the many inequities experienced by the disproportionate number of students labeled with LDs due to their intersectional identities of class, culture, race/ethnicity, and sex, research has indicated several points to move forward to better support such marginalized students.
Particularly for students of color who were diagnosed with LDs, they mentioned the importance of teacher support, availability of school counselors, additional programs, and the importance of connection between school and family to support their educational outcomes [28].
Student perspectives reported that they benefitted from flexible pedagogical and adaptive instructional choices that were responsive to their needs [28]. However, students reported that responsive instruction depended primarily on teachers’ abilities to prepare and effectively communicate their curriculum that is responsive to their students’ needs [28]. In this sense, this can be understood as evidence of LDs as the lack of appropriate instruction responsible by the school and teachers, as opposed to the labelling of students as having low achievement. In this sense, a culturally relevant RTI may be appropriate in having teachers provide responsive instruction that is mindful of their students’ diverse needs, including their intersectional identities.
Another component of responsive instruction that aligns with a culturally responsive RTI would be individualized supports [28]. Students reported individualized supports as beneficial for students to work at their own pace without having to keep up with the rest of the class. However, this same logic does not apply to putting students with LD into special education placement due to the lowered expectations and stigmatization placed onto students with LDs by being taken out of general education classrooms [28]. As such, this reiterates the onus placed onto the teacher to be able to create individualized support opportunities for students to work at their own pace, rather than taking them out of general education classrooms, which can lead to lowered academic expectations and increased social psychological risks.
Aligned with a culturally responsive RTI, students reported key adults that were supportive in their educational journey. School counselors were mentioned as instrumental in supporting students with their needs and also acted as a medium to advocate for additional support for students as well as providing emotional and behavioral support as students of color, in particular, were afraid to upset or hurt their family to speak about their academic struggles [28]. This is indicative that helping students manage conflicts with their peers and personal problems with their family. In other words, the additional support students with LDs required can be understood as simply additional supports that all students require due to diverse, cultural needs. For example, evidence has shown that students from low socioeconomic class and from minority cultures require additional support to respond to both their academic and socioemotional needs [10, 43, 46]. As such, school counselors is not only a support system that is beneficial for students with LDs, but responds to the needs of culturally and linguistically diverse students. Additionally, school counselors need to be mindful to not be disproportionate to boys due to the more apparent behaviors as this can under-identify the needs of girls from a lower socioeconomic status and culturally and linguistically diverse backgrounds.
Lastly, as the social model of disability focuses on understanding the societal factors that influence the students’ abilities to perform adequately along with their peers [6, 8], students brought up the importance of understanding school and family connections and how schools should be receptive to parental input and encourage collaboration and engagement between school and family [28]. Such communication, such as through online platforms, can facilitate parental contact with schools and promote family support, fostering a sense of family belonging for the student in their school environment. The important point is to foster this two-way street for home-school communication to maximize student support. This underlies general principles of culturally responsive RTI, such that a systemic view of support, bringing in family and multiple stakeholders, will be present to respond to the needs of students with diverse cultural and linguistic needs [19, 20]. Given that a tenet of the Individuals with Disabilities Education Improvement Act (IDEIA) is to formalize family support to foster dialog and collaboration in supporting students’ needs. An important focus here is that such home-school collaborations can ensure accountability in maintaining high expectations placed upon all students, and not only students who have been identified with the LD label. IDEIA and a culturally responsive RTI are frameworks that are not only focused on students with LD and, therefore, questions the need for the subjective notion of LD identification, and focus on a broader sense of providing adequate instruction that is responsive to culturally and linguistically diverse students [19, 20], rather than base LD identification on cognitive measures that can be subjectively biased [10, 37].
Providing universal support that is culturally responsive to all students, regardless of LD identification, is effective to remedy the achievement gaps that are present as a result of social inequities. The over-representation of culturally diverse students, including ethnic-racial minorities from lower social class as well as boys, in special education placements brings up an issue in the educational system and the inequitable dilemma: low achievement, negative stigmatization, school drop-outs, academic gaps are all outcomes pertaining to such diverse students particularly those being identified as having a LD [40, 47].
11. Conclusions
An examination of literature surrounding LD referral and identification revealed existing inequities in the educational system for students of intersecting identities, including students considered to be cultural and linguistic minorities, low socioeconomic class, and boys. Though the purpose of assigning LDs to students is to provide a process in which students with LDs can have access to special education services, much of the literature has reported negative consequences for students identified with LDs: low academic expectations, peer stigmatization (due to their special education placement, along with other marginalized identities), low self-esteem, school drop-out. As such, rather than focusing on LD referral and identification that may increase their academic and psychosocial risks, focusing on a culturally responsive RTI model can be a promising method in which all students, regardless of LD identification, can have both academic (e.g., increased academic engagement, achievement) and social benefits (e.g., positive classroom climate, increased belongingness to classroom) [48, 49, 50]. Future research is needed to increase the number of studies exploring intersectional students’ experiences with the LD label. As diversity and inclusion is an increasingly important topic in the current society, it is critical for equity researchers to understand and problem solve the inequities that exist to prevent students from non-dominant cultures to prosper alongside their peers.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"Learning Disability, Equity, Intersectionality, Education, Diversity, Culture",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77919.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77919.xml",downloadPdfUrl:"/chapter/pdf-download/77919",previewPdfUrl:"/chapter/pdf-preview/77919",totalDownloads:110,totalViews:0,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:1,impactScore:1,impactScorePercentile:69,impactScoreQuartile:3,hasAltmetrics:1,dateSubmitted:"July 14th 2021",dateReviewed:"July 20th 2021",datePrePublished:"August 12th 2021",datePublished:"March 30th 2022",dateFinished:"August 7th 2021",readingETA:"0",abstract:"This book chapter examines the intersection between learning disabilities (LD) and other marginalized identities to understand the diverse experiences of students with LDs and the disproportionalities that exist in LD identification and support in schools. Largely driven by the history and evolution of inclusion of disabilities in schools, Response to Intervention (RtI) arose as a model designed to increase academic performance among students with and without disabilities. Though RtI is a model shown to minimize inappropriate identification of LDs, intersectionality must be taken into consideration to understand the disproportionate representation of culturally and linguistically diverse (CLD) students in special education. Data from the National Assessment of Educational Progress suggest social factors (e.g. socioeconomic disadvantages, racial and ethnic intersection) as a potential cause for disproportionate representation and points to a need to further understand the disproportionality of different groups of students being over- or under-identified to receive special education services.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77919",risUrl:"/chapter/ris/77919",book:{id:"10910",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments"},signatures:"Enoch Leung",authors:[{id:"415915",title:"Ph.D. Student",name:"Enoch",middleName:null,surname:"Leung",fullName:"Enoch Leung",slug:"enoch-leung",email:"enoch.leung@mail.mcgill.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Learning disabilities",level:"1"},{id:"sec_3",title:"3. Response to intervention",level:"1"},{id:"sec_4",title:"4. Intersectionality",level:"1"},{id:"sec_5",title:"5. Educational issues for students with LD",level:"1"},{id:"sec_6",title:"6. Inequalities of culture and LDs",level:"1"},{id:"sec_7",title:"7. Inequality of sex and LDs",level:"1"},{id:"sec_8",title:"8. Inequalities of class and LDs",level:"1"},{id:"sec_9",title:"9. Intersectional identities in LD identification",level:"1"},{id:"sec_10",title:"10. Moving forward",level:"1"},{id:"sec_11",title:"11. Conclusions",level:"1"},{id:"sec_15",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'[Hayes AM, Bulat J. Disabilities inclusive education systems and policies guide for low- and middle-income countries. RTI Press. 2017; 1-40. DOI: 10.3768/rtipress.2017.op.0043.1707]'},{id:"B2",body:'[Cramer ED, Pellegrini-Lafont C, Gonzalez L. Towards culturally responsive and integrated instruction for all learners: The integrated learning model. Interdisciplinary Journal of Teaching and Learning. 2014;4:2:110-124]'},{id:"B3",body:'[Yell ML, Shriner JG, Katsiyannis A. Individuals with disabilities education improvement act of 2004 and IDEA regulations of 2006: Implications for educators, administrators, and teacher trainers. Focus on Exceptional Children. 2006;39:1:1-24]'},{id:"B4",body:'[Muniz J. Culturally responsive teaching: A 50-state survey of teaching standards. New America. 1-53. Available from: http://newamerica.org/education-policy/reports/culturally-responsive-teaching/ [Accessed: 2021-07-01]]'},{id:"B5",body:'[Walcot-Gayda E. Understanding learning disabilities. Learning Disabilities Association of Canada. Available from: https://www.ldac-acta.ca/understanding-learning-disabilities/ [Accessed: 2021-07-01]]'},{id:"B6",body:'[Barnes C. Understanding the social model of disability: Past, present and future. Routledge Handbook of Disability Studies. 2nd ed. Routledge; 2019. p. 14-31]'},{id:"B7",body:'[Gibbs SJ, Elliott JG. The dyslexia debate : Life without the label. Oxford Review of Education. 2020;46:4:487-500. DOI: 10.1080/03054985.2020.1747419]'},{id:"B8",body:'[Skiba RJ, Simmons AB, Ritter S, Gibb AC, Rausch MK, Cuadrado J, Chung CG. Achieving equity in special education: History, status, and current challenges. Exceptional Children. 2008;74:3:264-288. DOI: 10.1177/001440290807400301]'},{id:"B9",body:'[Shifrer D. Stigma of a label: Educational expectations for high school students labeled with learning disabilities. Journal of Health and Social Behavior. 2013;54:4:462-480. DOI: 10.1177/0022146513503346]'},{id:"B10",body:'[Shifrer D, Muller C, Callahan R. Disproportionality and learning disabilities: Parsing apart race, socioeconomic status, and language. Journal of Learning Disabilities. 2011;44:3:246-257. DOI: 10.1177/0022219410374236]'},{id:"B11",body:'[Taylor WP, Miciak J, Fletcher JM, Francis DJ. Cognitive discrepancy models for specific learning disabilities identification: Simulations of psychometric limitations. Journal of Psychoeducational Assessment. 2017;29:4:446-457. DOI: 10.1037/pas0000356]'},{id:"B12",body:'[Hibel J, Farkas G, Mogan PL. Who is placed into special education? Sociology of Education. 2010;83:4:312-332. DOI: 10.1177/0038040710383518]'},{id:"B13",body:'[Stuebing KK, Fletcher JM, Branum-Martin L, Francis DJ. Evaluation of the technical adequacy of three methods for identifying specific learning disabilities based on cognitive discrepancies. School Psychology Review. 2012;41:1:3-22]'},{id:"B14",body:'[Miciak J, Taylor WP, Stuebing KK, Fletcher JM. Simulation of LD identification accuracy using a pattern of processing strengths and weaknesses method with multiple measures. Journal of Psychoeducational Asessment. 2018;36:1:21-33. DOI: 10.1177/0734282916683287]'},{id:"B15",body:'[Pit-ten Cate IM, Glock S. Teachers’ implicit attitudes toward students from different social groups: A meta-analysis. Frontiers in Psychology. 2019;10:1-18. DOI: 10.3389/fpsyg.2019.02832]'},{id:"B16",body:'[UNESCO. World declaration on education for all and framework for action to meet basic learning needs. International Consultative Forum on Education for All. 1994;1-22]'},{id:"B17",body:'[Fletcher JM, Lyon GR, Fuchs LS, Barnes MA. Learning disabilities : From identification to intervention. The Guilford Press; 2019]'},{id:"B18",body:'[Fuchs D, Fuchs LS. Critique of the national evaluation of response to intervention: A case for simpler frameworks. Exceptional Children. 2017;83:3:255-268. DOI: 10.1177/0014402917693580]'},{id:"B19",body:'[Hart-Tervalon D, Skelton SM. Culturally responsive response to intervention: Considerations and critical questions. Region 4 PTAC Conference. 2012;1-30]'},{id:"B20",body:'[Montalvo R, Combes BH, Kea CD. Perspectives on culturally and linguistically responsive RtI pedagogics through a cultural and linguistics lens. Interdisciplinary Journal of Teaching and Learning. 2014;4:3:203-219]'},{id:"B21",body:'[Artiles AJ. Beyond responsiveness to identity badges: Future research on culture in disability and implications for Response to Intervention. 2015;67:1:1-22. DOI: 10.1080/00131911.2014.934322]'},{id:"B22",body:'[Kavale KA, Holdnack JA, Mostert MP. Responsiveness to Intervention and the identification of specific learning disability: A critique and alternative proposal. Learning Disability Quarterly. 2006;29:113-127]'},{id:"B23",body:'[Crenshaw K. Mapping the margins: Intersectionality, identity politics, and violence against women of color. Stanford Law Review. 1991;43:6:1241-1299. DOI: 10.2307/1229039]'},{id:"B24",body:'[American Psychological Association. Ethnic and racial disparities in education: Psychology’s contributions to understanding and reducing disparities. Presidential Task Force on Educational Disparities. 1-121. Available from: http://www.apa.org/ed/resources/racial-disparities.aspx [Accessed on 2021-07-01]]'},{id:"B25",body:'[National Center for Learning Disabilities (NCLD). Significant disproportionality in special education: Current trends and actions for impact. Washington;2020;1-14. Available from: http://ies.ed.gov/ncee/edlabs [Accessed on 2021-07-01]]'},{id:"B26",body:'[Burr E, Haas E, Ferriere K. Identifying and supporting English learner students with learning disabilities: Key issues in the literature and state practice. National Center for Education Evaluation and Regional Assistance. 1-62. Available from: http://ies.ed.gov/ncee/edlabs [Accessed on 2021-07-01]]'},{id:"B27",body:'[Trainor AA, Robertson PM. Culturally and linguistically diverse students with learning disabilities: Building a framework for addressing equity through empirical research. Learning Disability Quarterly. 2020;1-9. DOI: 10.1177/0731948720929001]'},{id:"B28",body:'[Connor DJ, Cavendish W, Hallaran A, Olander L. “I’m bright enough to do it, even though sometimes I feel I can’t do it”: Perspectives of high school students with learning disabilities about existing supports to achieve graduation. Disability Studies Quarterly. 2020;40:2 DOI: 10.18061/dsq.v40i2.6665]'},{id:"B29",body:'[Ford J. Educating students with learning disabilities in inclusive classrooms. Electronic Journal for Inclusive Education. 2013;3:1:1-20]'},{id:"B30",body:'[Shifrer D. Learning disabilities and inequality. Sociology Compass. 2013;7:8:656-669. DOI: 10.1111/soc4.12055]'},{id:"B31",body:'[Blanchett WJ. Telling it like it is: The role of race, class, & culture in the perpetuation of learning disability as a privileged category for the White middle class. Disability Studies Quarterly. 2010;30:2]'},{id:"B32",body:'[Vavrus M. Culturally responsive teaching. 21st century education: A reference handbook. 2nd ed. Thousand Oaks;2008. p. 49-57]'},{id:"B33",body:'[Howley A, Craft E. African American students’ experiences in special education programs. Teachers College Record. 2018:12;1-35]'},{id:"B34",body:'[Gloppen KM, Gower AL, McMorris BJ, Eisenberg ME. Associations between peer harassment and school risk and protection profiles. Journal of School Health. 2017;87:11:832-841. DOI: 10.1111/josh.12557]'},{id:"B35",body:'[Estrada KV. Examining English language development among English language learners with specific learning disability [dissertation]. Los Angeles: Loyola Marymount University; 2013]'},{id:"B36",body:'[Williams KJ, Martinez LR. Supporting reading comprehension for students who are learning English and have learning disabilities. Intervention in School and Clinic. 2019;55:1:23-31. DOI: 10.1177/1053451219833019]'},{id:"B37",body:'[Ashraf F, Najam N. Identification of learning disabilities in students: A gender perspective. Pakistan Journal of Social and Clinical Psychology. 2017;15:1:36-41]'},{id:"B38",body:'[Shifrer D, Callahan RM, Muller C. Equity or marginalization? The high school course-taking of students labeled with a learning disability. American Educational Research Journal. 2013;50:4:656-682. DOI: 10.3102/0002831213479439]'},{id:"B39",body:'[Niklas F, Cohrssen C, Tayler C. The sooner, the better: Early reading to children. SAGE Open. 2016;6:4:1-11. DOI: 10.1177/2158244016672715]'},{id:"B40",body:'[OECD. Equity and quality in education: Supporting disadvantaged students and schools. OECD Publishing; 2012. DOI: 10.1787/9789264130852-en]'},{id:"B41",body:'[Leath S, Mathews C, Harrison A, Chavous T. Racial identity, racial discrimination, and classroom engagement outcomes among Black girls and boys in predominantly Black and predominantly White school districts. American Education Research Journal. 2019;56:4:1318-1352. DOI: 10.3102/0002831218816955]'},{id:"B42",body:'[Siegel LS. Confessions and reflections of the black sheep of the learning disabilities field. Australian Journal of Learning Difficulties. 2012;17:2:63-77. DOI: 10.1080/19404158.2012.722115]'},{id:"B43",body:'[Fish RE. Standing out and sorting in: Exploring the role of racial composition in racial disparities in special education. American Educational Research Journal. 2019;56:6:2573-2608. DOI: 10.3102/0002831219847966]'},{id:"B44",body:'[Besic E. Intersectionality: A pathway towards inclusive education? Prospects. 2020;49:111-122. DOI:10.1007/s11125-020-09461-6]'},{id:"B45",body:'[Cherng HYS. If they think I can: Teacher bias and youth of color expectations and achievement. Social Science Research. 2017;66:170-186. DOI: 10.1016/j.ssresearch.2017.04.001]'},{id:"B46",body:'[Daley SG, Rappolt-Schlichtmann G. Stigma consciousness among adolescents with learning disabilities: Considering individual experiences of being stereotyped. Learning Disability Quarterly. 2018;41:4:200-212. DOI: 10.1177/0731948718785565]'},{id:"B47",body:'[Lisle K. Identifying the negative stigma associated with having a learning disability (thesis). Pennsylvania: Bucknell University; 2011]'},{id:"B48",body:'[Kourea L, Gibson L, Werunga R. Culturally responsive reading instruction for students with learning disabilities. Intervention in School and Clinic. 2018;53:3:153-162. DOI: 10.1177/1053451217702112]'},{id:"B49",body:'[Portes PR, Canche MG, Boada D, Whatley ME. Early evaluation findings from the instructional conversation study: Culturally responsive teaching outcomes for diverse learners in elementary school]'},{id:"B50",body:'[Dufour E. Learning disabilities and diversity: A culturally responsive approach. LD @ School;2015. Available from: https://www.ldatschool.ca/culturally-responsive-pedagogy/ [Accessed on 2021-07-01]]'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Enoch Leung",address:"enoch.leung@mail.mcgill.ca",affiliation:'- McGill University, Montréal, Canada
'}],corrections:null},book:{id:"10910",type:"book",title:"Learning Disabilities",subtitle:"Neurobiology, Assessment, Clinical Features and Treatments",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",publishedDate:"March 30th 2022",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/10910.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-588-0",printIsbn:"978-1-83968-587-3",pdfIsbn:"978-1-83968-589-7",reviewType:"peer-reviewed",numberOfWosCitations:0,isAvailableForWebshopOrdering:!0,editors:[{id:"103586",title:null,name:"Sandro",middleName:null,surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1239"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"79619",type:"chapter",title:"Types of Specific Learning Disability",slug:"types-of-specific-learning-disability",totalDownloads:229,totalCrossrefCites:0,signatures:"Vinutha U. Muktamath, Priya R. Hegde and Samreen Chand",reviewType:"peer-reviewed",authors:[{id:"417879",title:"Assistant Prof.",name:"Vinutha U.",middleName:null,surname:"Muktamath",fullName:"Vinutha U. Muktamath",slug:"vinutha-u.-muktamath"},{id:"428478",title:"Ms.",name:"Priya R.",middleName:null,surname:"Hegde",fullName:"Priya R. Hegde",slug:"priya-r.-hegde"},{id:"428479",title:"Ms.",name:"Samreen",middleName:null,surname:"Chand",fullName:"Samreen Chand",slug:"samreen-chand"}]},{id:"78383",type:"chapter",title:"Biological Understanding of Neurodevelopmental Disorders Based on Epigenetics, a New Genetic Concept in Education",slug:"biological-understanding-of-neurodevelopmental-disorders-based-on-epigenetics-a-new-genetic-concept-",totalDownloads:107,totalCrossrefCites:0,signatures:"Takeo Kubota",reviewType:"peer-reviewed",authors:[{id:"417045",title:"Prof.",name:"Takeo",middleName:null,surname:"Kubota",fullName:"Takeo Kubota",slug:"takeo-kubota"}]},{id:"78359",type:"chapter",title:"Self-Regulation, Self-Efficacy, and Learning Disabilities",slug:"self-regulation-self-efficacy-and-learning-disabilities",totalDownloads:279,totalCrossrefCites:0,signatures:"Dale H. Schunk and Maria K. DiBenedetto",reviewType:"peer-reviewed",authors:[{id:"418379",title:"Prof.",name:"Dale H.",middleName:null,surname:"Schunk",fullName:"Dale H. Schunk",slug:"dale-h.-schunk"},{id:"418381",title:"Dr.",name:"Maria K.",middleName:null,surname:"DiBenedetto",fullName:"Maria K. DiBenedetto",slug:"maria-k.-dibenedetto"}]},{id:"80429",type:"chapter",title:"Neuropsychological Assessment of Children with Learning Disabilities",slug:"neuropsychological-assessment-of-children-with-learning-disabilities",totalDownloads:71,totalCrossrefCites:0,signatures:"Sandro Misciagna",reviewType:"peer-reviewed",authors:[{id:"103586",title:null,name:"Sandro",middleName:null,surname:"Misciagna",fullName:"Sandro Misciagna",slug:"sandro-misciagna"}]},{id:"77919",type:"chapter",title:"Examining Learning Disabilities in Schools through an Intersectional and Equitable Lens",slug:"examining-learning-disabilities-in-schools-through-an-intersectional-and-equitable-lens",totalDownloads:110,totalCrossrefCites:1,signatures:"Enoch Leung",reviewType:"peer-reviewed",authors:[{id:"415915",title:"Ph.D. Student",name:"Enoch",middleName:null,surname:"Leung",fullName:"Enoch Leung",slug:"enoch-leung"}]},{id:"80202",type:"chapter",title:"Depression, Suicidal Tendencies, Hopelessness, and Stress among Patients with Learning Disabilities",slug:"depression-suicidal-tendencies-hopelessness-and-stress-among-patients-with-learning-disabilities",totalDownloads:99,totalCrossrefCites:0,signatures:"Fahad Hassan Shah, Song Ja Kim, Laiba Zakir, Aqsa Ehsan, Sohail Riaz, Muhammad Sulaiman and Saad Salman",reviewType:"peer-reviewed",authors:[{id:"418086",title:"Dr.",name:"Saad",middleName:null,surname:"Salman",fullName:"Saad Salman",slug:"saad-salman"},{id:"439291",title:"Dr.",name:"Fahad Hassan",middleName:null,surname:"Shah",fullName:"Fahad Hassan Shah",slug:"fahad-hassan-shah"},{id:"439292",title:"Dr.",name:"Song Ja",middleName:null,surname:"Kim",fullName:"Song Ja Kim",slug:"song-ja-kim"},{id:"439293",title:"Dr.",name:"Laiba",middleName:null,surname:"Zakir",fullName:"Laiba Zakir",slug:"laiba-zakir"},{id:"439294",title:"Dr.",name:"Aqsa",middleName:null,surname:"Ehsan",fullName:"Aqsa Ehsan",slug:"aqsa-ehsan"},{id:"451112",title:"Dr.",name:"Sohail",middleName:null,surname:"Riaz",fullName:"Sohail Riaz",slug:"sohail-riaz"},{id:"451113",title:"Dr.",name:"Muhammad",middleName:null,surname:"Sulaiman",fullName:"Muhammad Sulaiman",slug:"muhammad-sulaiman"}]},{id:"78041",type:"chapter",title:"Counseling Parents of Special Children: Insight from Resilient Parents",slug:"counseling-parents-of-special-children-insight-from-resilient-parents",totalDownloads:86,totalCrossrefCites:0,signatures:"Radhika Mohan",reviewType:"peer-reviewed",authors:[{id:"416959",title:"Dr.",name:"Radhika",middleName:null,surname:"Mohan",fullName:"Radhika Mohan",slug:"radhika-mohan"}]},{id:"79195",type:"chapter",title:"Learning Disorder (Dyslexia): An Overview Description of the Entity through Available Researches",slug:"learning-disorder-dyslexia-an-overview-description-of-the-entity-through-available-researches",totalDownloads:132,totalCrossrefCites:0,signatures:"Sambhu Prasad and Rajesh Sagar",reviewType:"peer-reviewed",authors:[{id:"417903",title:"Assistant Prof.",name:"Sambhu",middleName:null,surname:"Prasad",fullName:"Sambhu Prasad",slug:"sambhu-prasad"},{id:"456868",title:"Dr.",name:"Rajesh",middleName:null,surname:"Sagar",fullName:"Rajesh Sagar",slug:"rajesh-sagar"}]},{id:"78321",type:"chapter",title:"Phonological Deficit Traits in Verbal Language of Dyslexics",slug:"phonological-deficit-traits-in-verbal-language-of-dyslexics",totalDownloads:138,totalCrossrefCites:0,signatures:"Aya Adel and Marwa Mahmoud Saleh",reviewType:"peer-reviewed",authors:[{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",fullName:"Marwa Mahmoud Saleh",slug:"marwa-mahmoud-saleh"},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",fullName:"Aya Adel",slug:"aya-adel"}]},{id:"77883",type:"chapter",title:"Neuropsychological Perspective on Dyslexia",slug:"neuropsychological-perspective-on-dyslexia",totalDownloads:174,totalCrossrefCites:0,signatures:"María-José González-Valenzuela and Isaías Martín-Ruiz",reviewType:"peer-reviewed",authors:[{id:"201295",title:"Dr.",name:"Maria-Jose",middleName:null,surname:"Gonzalez-Valenzuela",fullName:"Maria-Jose Gonzalez-Valenzuela",slug:"maria-jose-gonzalez-valenzuela"},{id:"417743",title:"Dr.",name:"Isaías",middleName:null,surname:"Martín- Ruiz",fullName:"Isaías Martín- Ruiz",slug:"isaias-martin-ruiz"}]},{id:"78552",type:"chapter",title:"Oral Language Skills and Literacy Skills of Malay Children with Dyslexia",slug:"oral-language-skills-and-literacy-skills-of-malay-children-with-dyslexia",totalDownloads:151,totalCrossrefCites:0,signatures:"Rogayah A. Razak, Loke Xing Lin and Mohd Azmarul A. Aziz",reviewType:"peer-reviewed",authors:[{id:"419028",title:"Dr.",name:"Rogayah",middleName:null,surname:"Razak",fullName:"Rogayah Razak",slug:"rogayah-razak"},{id:"427897",title:"Ms.",name:"Xing Lin",middleName:null,surname:"Loke",fullName:"Xing Lin Loke",slug:"xing-lin-loke"},{id:"427898",title:"Mr.",name:"Mohd Azmarul",middleName:null,surname:"A.Aziz",fullName:"Mohd Azmarul A.Aziz",slug:"mohd-azmarul-a.aziz"}]},{id:"79900",type:"chapter",title:"Dyslexia, Dysgraphia and Dyscalculia: A Response to Intervention Approach to Classification",slug:"dyslexia-dysgraphia-and-dyscalculia-a-response-to-intervention-approach-to-classification",totalDownloads:152,totalCrossrefCites:0,signatures:"Charles Potter",reviewType:"peer-reviewed",authors:[{id:"93190",title:"Dr.",name:"Charles",middleName:null,surname:"Potter",fullName:"Charles Potter",slug:"charles-potter"}]},{id:"78256",type:"chapter",title:"Impacts of Dyscalculia in Learning Mathematics: Some Considerations for Content Delivery and Support",slug:"impacts-of-dyscalculia-in-learning-mathematics-some-considerations-for-content-delivery-and-support",totalDownloads:189,totalCrossrefCites:0,signatures:"Rajendra Kunwar",reviewType:"peer-reviewed",authors:[{id:"416945",title:"Associate Prof.",name:"Rajendra",middleName:null,surname:"Kunwar",fullName:"Rajendra Kunwar",slug:"rajendra-kunwar"}]},{id:"79170",type:"chapter",title:"Attention and Learning Disabilities",slug:"attention-and-learning-disabilities",totalDownloads:108,totalCrossrefCites:0,signatures:"Audhild Løhre",reviewType:"peer-reviewed",authors:[{id:"418731",title:"Prof.",name:"Audhild",middleName:null,surname:"Løhre",fullName:"Audhild Løhre",slug:"audhild-lohre"}]},{id:"79122",type:"chapter",title:"Autism Spectrum Disorder (ASD): From Molecular Mechanism to Novel Therapeutic Approach",slug:"autism-spectrum-disorder-asd-from-molecular-mechanism-to-novel-therapeutic-approach",totalDownloads:120,totalCrossrefCites:0,signatures:"Hagit Friedman",reviewType:"peer-reviewed",authors:[{id:"206485",title:"Dr.",name:"Hagit",middleName:null,surname:"Friedman",fullName:"Hagit Friedman",slug:"hagit-friedman"}]},{id:"79488",type:"chapter",title:"Evidence Based Reading Strategies for Struggling Readers with Learning Disabilities and Emotional Disorders",slug:"evidence-based-reading-strategies-for-struggling-readers-with-learning-disabilities-and-emotional-di",totalDownloads:24,totalCrossrefCites:0,signatures:"Argnue Chitiyo",reviewType:"peer-reviewed",authors:[{id:"312626",title:"Dr.",name:"Argnue",middleName:null,surname:"Chitiyo",fullName:"Argnue Chitiyo",slug:"argnue-chitiyo"}]},{id:"78375",type:"chapter",title:"The Use of Assistive Technologies in Writing Situations with Dyslexic and Dysorthographic Students",slug:"the-use-of-assistive-technologies-in-writing-situations-with-dyslexic-and-dysorthographic-students",totalDownloads:112,totalCrossrefCites:0,signatures:"Nadia Rousseau, Michelle Dumont and Carl Beaudoin",reviewType:"peer-reviewed",authors:[{id:"419644",title:"Ph.D.",name:"Nadia",middleName:null,surname:"Rousseau",fullName:"Nadia Rousseau",slug:"nadia-rousseau"},{id:"428434",title:"Dr.",name:"Michelle",middleName:null,surname:"Dumont",fullName:"Michelle Dumont",slug:"michelle-dumont"},{id:"428435",title:"Dr.",name:"Carl",middleName:null,surname:"Beaudoin",fullName:"Carl Beaudoin",slug:"carl-beaudoin"}]},{id:"79592",type:"chapter",title:"Lecturers Awareness, Inclusion and Implementation of Wearable Device as a Means of Enhancing Educational Development in Nigerian Universities",slug:"lecturers-awareness-inclusion-and-implementation-of-wearable-device-as-a-means-of-enhancing-educatio",totalDownloads:92,totalCrossrefCites:0,signatures:"Ayodeji Olayemi Obafemi",reviewType:"peer-reviewed",authors:[{id:"419163",title:"Ph.D. Student",name:"Ayodeji Olayemi",middleName:null,surname:"Obafemi",fullName:"Ayodeji Olayemi Obafemi",slug:"ayodeji-olayemi-obafemi"}]},{id:"77209",type:"chapter",title:"Functional Model for Emotional Information Processing: A Validated Model to Support Social Competence of Students with ADHD",slug:"functional-model-for-emotional-information-processing-a-validated-model-to-support-social-competence",totalDownloads:14,totalCrossrefCites:0,signatures:"Mourad Ali Eissa Saad",reviewType:"peer-reviewed",authors:[{id:"417851",title:"Prof.",name:"Mourad",middleName:null,surname:"Ali Eissa Saad",fullName:"Mourad Ali Eissa Saad",slug:"mourad-ali-eissa-saad"}]},{id:"77236",type:"chapter",title:"Educational Intervention in Social-Emotional Competence in Students with Autism Spectrum Disorders (ASD)",slug:"educational-intervention-in-social-emotional-competence-in-students-with-autism-spectrum-disorders-a",totalDownloads:277,totalCrossrefCites:0,signatures:"Marina Jodra",reviewType:"peer-reviewed",authors:[{id:"416351",title:"Ph.D.",name:"Marina",middleName:null,surname:"Jodra",fullName:"Marina Jodra",slug:"marina-jodra"}]},{id:"79967",type:"chapter",title:"Stem Cell Therapy for Learning Disability",slug:"stem-cell-therapy-for-learning-disability",totalDownloads:81,totalCrossrefCites:0,signatures:"Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Sakshi Desai, Pooja Kulkarni and Prerna Badhe",reviewType:"peer-reviewed",authors:[{id:"169970",title:"Dr.",name:"Pooja",middleName:null,surname:"Kulkarni",fullName:"Pooja Kulkarni",slug:"pooja-kulkarni"},{id:"196900",title:"Dr.",name:"Alok",middleName:null,surname:"Sharma",fullName:"Alok Sharma",slug:"alok-sharma"},{id:"204449",title:"Dr.",name:"Hemangi",middleName:null,surname:"Sane",fullName:"Hemangi Sane",slug:"hemangi-sane"},{id:"277771",title:"Dr.",name:"Nandini",middleName:null,surname:"Gokulchandran",fullName:"Nandini Gokulchandran",slug:"nandini-gokulchandran"},{id:"443163",title:"Ms.",name:"Sakshi",middleName:null,surname:"Desai",fullName:"Sakshi Desai",slug:"sakshi-desai"},{id:"443164",title:"Dr.",name:"Prerna",middleName:null,surname:"Badhe",fullName:"Prerna Badhe",slug:"prerna-badhe"}]}]},relatedBooks:[{type:"book",id:"3454",title:"Positron Emission Tomography",subtitle:"Recent Developments in Instrumentation, Research and Clinical Oncological Practice",isOpenForSubmission:!1,hash:"391535d2cdebfe48d3fd6822480d9079",slug:"positron-emission-tomography-recent-developments-in-instrumentation-research-and-clinical-oncological-practice",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/3454.jpg",editedByType:"Edited by",editors:[{id:"103586",title:null,name:"Sandro",surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"45892",title:"Implementation of TOF-PET Systems on Advanced Reconfigurable Logic Devices",slug:"implementation-of-tof-pet-systems-on-advanced-reconfigurable-logic-devices",signatures:"J. Torres, R. García, A. Aguilar, J. Soret, J. Martos, A.J. González, F.\nSánchez, J.M. Benlloch and M.J. Rodríguez",authors:[{id:"77545",title:"Dr.",name:"Raimundo",middleName:null,surname:"Garcia",fullName:"Raimundo Garcia",slug:"raimundo-garcia"}]},{id:"45883",title:"Positron Emission Tomography-Computed Tomography Data Acquisition and Image Management",slug:"positron-emission-tomography-computed-tomography-data-acquisition-and-image-management",signatures:"Todd Faasse",authors:[{id:"77411",title:"Mr.",name:"Todd",middleName:null,surname:"Faasse",fullName:"Todd Faasse",slug:"todd-faasse"}]},{id:"45953",title:"Basic PET Data Analysis Techniques",slug:"basic-pet-data-analysis-techniques",signatures:"Karmen K. Yoder",authors:[{id:"162621",title:"Dr.",name:"Karmen",middleName:null,surname:"Yoder",fullName:"Karmen Yoder",slug:"karmen-yoder"}]},{id:"45837",title:"Functional Imaging Studies of Human Cognition Using Positron Emission Tomography",slug:"functional-imaging-studies-of-human-cognition-using-positron-emission-tomography",signatures:"Sandro Misciagna",authors:[{id:"103586",title:null,name:"Sandro",middleName:null,surname:"Misciagna",fullName:"Sandro Misciagna",slug:"sandro-misciagna"}]},{id:"45909",title:"How to Study Smoking and Drinking with PET",slug:"how-to-study-smoking-and-drinking-with-pet",signatures:"Evan D. Morris, Molly V. Lucas and Kelly P. Cosgrove",authors:[{id:"160427",title:"Prof.",name:"Evan",middleName:null,surname:"Morris",fullName:"Evan Morris",slug:"evan-morris"},{id:"161978",title:"Dr.",name:"Kelly P.",middleName:null,surname:"Cosgrove",fullName:"Kelly P. Cosgrove",slug:"kelly-p.-cosgrove"}]},{id:"45884",title:"PET Imaging of the Serotoninergic 5-HT1A System",slug:"pet-imaging-of-the-serotoninergic-5-ht1a-system",signatures:"Amélie Lothe, Sandrine Bouvard and Philippe Ryvlin",authors:[{id:"161162",title:"Dr.",name:"Amélie",middleName:null,surname:"Lothe",fullName:"Amélie Lothe",slug:"amelie-lothe"},{id:"162082",title:"Dr.",name:"Sandrine",middleName:null,surname:"Bouvard",fullName:"Sandrine Bouvard",slug:"sandrine-bouvard"},{id:"162083",title:"Prof.",name:"Philippe",middleName:null,surname:"Ryvlin",fullName:"Philippe Ryvlin",slug:"philippe-ryvlin"}]},{id:"45775",title:"Pathological Gambling: PET Studies",slug:"pathological-gambling-pet-studies",signatures:"Daniela Santoro and Stefano Pallanti",authors:[{id:"160524",title:"Dr.",name:"Daniela",middleName:null,surname:"Santoro",fullName:"Daniela Santoro",slug:"daniela-santoro"},{id:"160571",title:"Dr.",name:"Suzana Alexandra",middleName:null,surname:"Corciova",fullName:"Suzana Alexandra Corciova",slug:"suzana-alexandra-corciova"},{id:"161459",title:"Prof.",name:"Stefano",middleName:null,surname:"Pallanti",fullName:"Stefano Pallanti",slug:"stefano-pallanti"}]},{id:"45977",title:"PET – Assessment of Oncologic Treatment Response",slug:"pet-assessment-of-oncologic-treatment-response",signatures:"Inga S. Grills and Victor S. Mangona",authors:[{id:"161620",title:"Dr.",name:"Inga",middleName:null,surname:"Grills",fullName:"Inga Grills",slug:"inga-grills"},{id:"161621",title:"Dr.",name:"Victor",middleName:null,surname:"Mangona",fullName:"Victor Mangona",slug:"victor-mangona"}]},{id:"45922",title:"PET-CT in Anal Cancer: Indications and Limits",slug:"pet-ct-in-anal-cancer-indications-and-limits",signatures:"Massimiliano Mistrangelo and Adriana Lesca",authors:[{id:"159041",title:"Ph.D.",name:"Massimiliano",middleName:null,surname:"Mistrangelo",fullName:"Massimiliano Mistrangelo",slug:"massimiliano-mistrangelo"}]},{id:"45952",title:"Early Prediction of Tumor Response: A Future Strategy for Optimizing Cancer Treatment",slug:"early-prediction-of-tumor-response-a-future-strategy-for-optimizing-cancer-treatment",signatures:"Shigeto Ueda and Toshiaki Saeki",authors:[{id:"161097",title:"Dr.",name:"Shigeto",middleName:null,surname:"Ueda",fullName:"Shigeto Ueda",slug:"shigeto-ueda"},{id:"167282",title:"Dr.",name:"Toshiaki",middleName:null,surname:"Saeki",fullName:"Toshiaki Saeki",slug:"toshiaki-saeki"}]}]}],publishedBooks:[{type:"book",id:"715",title:"Learning Disabilities",subtitle:null,isOpenForSubmission:!1,hash:"7cf7910a2068cff1fdcdfd5ed3c25cc7",slug:"learning-disabilities",bookSignature:"Wichian Sittiprapaporn",coverURL:"https://cdn.intechopen.com/books/images_new/715.jpg",editedByType:"Edited by",editors:[{id:"73395",title:"Dr.",name:"Phakkharawat",surname:"Sittiprapaporn",slug:"phakkharawat-sittiprapaporn",fullName:"Phakkharawat Sittiprapaporn"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10228",title:"Dyslexia",subtitle:null,isOpenForSubmission:!1,hash:"6b4060d23ac02fcb4a11313ec1c911c6",slug:"dyslexia",bookSignature:"Jonathan Glazzard and Samuel Stones",coverURL:"https://cdn.intechopen.com/books/images_new/10228.jpg",editedByType:"Edited by",editors:[{id:"294281",title:"Prof.",name:"Jonathan",surname:"Glazzard",slug:"jonathan-glazzard",fullName:"Jonathan Glazzard"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10910",title:"Learning Disabilities",subtitle:"Neurobiology, Assessment, Clinical Features and Treatments",isOpenForSubmission:!1,hash:"0999e5f759c2380ae5a4a2ee0835c98d",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/10910.jpg",editedByType:"Edited by",editors:[{id:"103586",title:null,name:"Sandro",surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6593",title:"Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"88cae11440930f7ba788d5cfedec5979",slug:"decision-making",bookSignature:"Fausto Pedro García Márquez, Alberto Pliego Marugán and Mayorkinos Papaelias",coverURL:"https://cdn.intechopen.com/books/images_new/6593.jpg",editedByType:"Edited by",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10978",title:"Mind and Matter",subtitle:"Challenges and Opportunities in Cognitive Semiotics and Aesthetics",isOpenForSubmission:!1,hash:"938b8668018c9338fbc8992e8e03f971",slug:"mind-and-matter-challenges-and-opportunities-in-cognitive-semiotics-and-aesthetics",bookSignature:"Asun López-Varela Azcárate",coverURL:"https://cdn.intechopen.com/books/images_new/10978.jpg",editedByType:"Edited by",editors:[{id:"302731",title:null,name:"Asun",surname:"López-Varela Azcárate",slug:"asun-lopez-varela-azcarate",fullName:"Asun López-Varela Azcárate"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"10910",title:"Learning Disabilities",subtitle:"Neurobiology, Assessment, Clinical Features and Treatments",isOpenForSubmission:!1,hash:"0999e5f759c2380ae5a4a2ee0835c98d",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/10910.jpg",editedByType:"Edited by",editors:[{id:"103586",title:null,name:"Sandro",surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"79900",title:"Dyslexia, Dysgraphia and Dyscalculia: A Response to Intervention Approach to Classification",doi:"10.5772/intechopen.101163",slug:"dyslexia-dysgraphia-and-dyscalculia-a-response-to-intervention-approach-to-classification",body:'1. Introduction
The field of learning disabilities has a long history, stemming back diagnostically over the past century to the work of Hinshelwood [1] and Morgan [2] in the 1890’s, and the work of Orton in the 1920’s and 1930’s with children characterised as “word blind” [3, 4]. Methodologically, it can be traced to the techniques for treating reading, writing and spelling difficulties pioneered by Dearborn [5, 6], Monroe [7], Gates [8], Durrell [9], and Fernald [10], to the application of Orton’s theories by Gillingham and Stillman [11] and to the differing conceptualisations of treatment developed by Strauss and Lehtinen in the 1940’s [12] and by clinicians such as Cruickshank [13], Ayres [14], Dubnoff [15], Frostig [16], Kephart [17], Getman [18], Kirk [19], Spalding and Spalding [20], Freidus [21], and Johnson and Myklebust [22] in the 1950’s and 1960’s.
In teaching children to read there has also been intense debate between proponents of phonically based techniques and visually-based methods as summarised in Chall [23], as well as between those who have advocated or rejected the practice of classifying and labelling different types of reading disabilities, as outlined by Elliott and Grigorenko [24]. These debates are ongoing [25].
At this point in time, based on over a hundred years of clinical and academic work in the field, the value of teaching reading using phonologically and phonically based methods at entry point to school and also at foundation level in school has become widely accepted [26, 27, 28]. In addition, a number of different types of learning disabilities have been identified [29, 30].
Despite these advances, there is still lack of agreement as to typologies of learning disabilities, as well as to how these apply to children and adults. There is also a lack of consensus as to whether it is better to base diagnosis of learning disabilities on purely functional descriptions of the behaviours associated with how learning disabilities manifest in particular children (using terms such as “backward reading”, “specific learning disorder, with impairment in reading”, or “specific reading retardation”), or whether it is helpful to also apply a label such as “dyslexia”, “developmental dyslexia”, “dysgraphia”, or “dyscalculia” to children for diagnostic purposes.
This chapter describes a programme which uses a response to intervention model of classification [31, 32, 33], working from the standpoint that classifications of learning difficulties are provisional and emergent, with the potential of changing from hypotheses to firm and persistent categories as treatment progresses. The model is based on a process of incremental and treatment validity, in which evidence concerning a child’s response to particular procedures or techniques can add to an existing combination of assessment methods [34, 35, 36].
The model is then discussed in relation to the methods for assessment and treatment of functional difficulties with reading, writing, spelling and arithmetical concepts applied in the programme. As the difficulties of children are specific and manifest in the context of particular households and school environments, initial functional descriptions of behaviour are used in the programme as the basis for treating learning difficulties associated with difficulties with reading, writing, spelling and numeracy.
The approach to diagnosis and treatment is evidence-based, and described in Potter [37, 38]. Initial assessment provides descriptive information concerning a child’s functioning, which is then linked to specific treatment programmes. Firm classification of dyslexia, dysgraphia and dysgraphia is then linked to both ongoing assessment and to progress evaluation linked to indicators of progress to establish effects of treatment, and through this to firm classification as learning disabled [39].
2. Classification of learning disabilities
Lyon et al. [40] suggest that classification research involves forming groups or categories, which can then be evaluated for reliability, validity, and coverage. This implies that all classifications are essentially hypotheses about variables, and the relationships between variables. Classifications applying in the area of learning disabilities thus relate to both variables indicating difficulties as well as variables relating to the treatment of difficulties. Classification researchers then evaluate the reliability, validity, and coverage of hypothetical groupings of both independent and dependent variables relating to both difficulties and treatment of difficulties. This is done by conducting and analysing research on the relationships between these variables, as well as the relationships between variables conceptualised as either dependent or independent [41].
Following this logic, classifications applying in the area of learning disabilities are based on the interrelationships between a wide range of variables based on indicators associated with the learning difficulties experienced by particular children at school. As many types of behaviour are associated with both successful and unsuccessful performance in particular school environments, it would also imply that it would be unlikely that learning difficulties can be conceptualised as related to a single disability. Instead learning disability would need to be represented as a general category, which is composed of disabilities in any one or a combination of several areas or domains as these apply to the development of particular children [42].
This is the standpoint adopted in the programme described in this chapter, based on the position previously taken by others. In the 1968 federal definition of learning disabilities adopted in the United States, for example, seven domains are identified: (1) listening; (2) speaking; (3) basic reading (decoding and word recognition); (4) reading comprehension; (5) arithmetic calculation; (6) mathematics reasoning; and (7) written expression [30, 43], while Fletcher et al. [44] have suggested that the evidence supports six subgroups of learning disability involving reading (word recognition, fluency, and comprehension), math (calculations and problem solving), and probably written expression. The latter could involve either the generation of text (handwriting, spelling) or composition. Further research would be needed on these written expression components to establish whether these are distinct categories or categories which overlap other forms of learning disability.
Within these domains, the programme described in this chapter focuses on three main subgroups of learning disability:
Reading disabilities (often referred to as dyslexia)
Written language disabilities (often referred to as dysgraphia)
Math disabilities (often called dyscalculia)
Other related categories treated in the programme include disabilities that affect focus and attention, working memory, social skills, and executive functions such as personal organisation and deciding how to approach or begin a task. These difficulties are initially described functionally [37]. This is followed by a process of firmer classification based on analysis of response to intervention to programmes focused on improving functioning and performance in these areas, based on a process of evaluation which is empirical, multimethod and evidence-based [45, 46, 47].
3. Functional description of different types of learning difficulties: a response to intervention perspective
A response to intervention instructional model uses intervention as a treatment variable and response to intervention as an indicator of underlying learning disabilities. Firm classification is then based on evidence of learning difficulties which are persistent or resistant to treatment. This is the approach adopted in Dr. Charles Potter’s Reading Fluency Programme [48], which is described in this chapter. Given the difficulties inherent in measurement particularly where anxiety and emotion are involved, the programme uses a response to intervention approach in which diagnosis can be emergent, based on evidence from both response-to-intervention (RTI) and norm-referenced ability testing collected over time [49].
Since difficulties with reading, writing and/or math are recognisable problems during the school years, the signs and symptoms of learning difficulties in a particular school programme form the point of departure for treatment. Functional description of different types of learning difficulties forms the basis for establishing treatment programmes. Response to intervention then provides the basis for classification as learning disabled.
Learning disabilities are thus initially defined as functional difficulties, based on evidence of unexpected underachievement in a child relative to the achievement which would be typical of other children in a particular school or learning environment. Indicators of unexpected underachievement are used at the outset to describe the difficulty, based on inability to respond to the instruction which is benefitting other children. The definition would also include other functional indicators of learning difficulties, such as ratings or test scores indicating reading, writing and spelling difficulties or difficulties with number concept and mathematical problem-solving, and would also include ratings or test scores indicating neurological markers and signs, as well as unevenness in cognitive functions.
A firm classification as learning disabled would then be based on evidence of difficulties persisting both during as well as after treatment based on longitudinal, incremental assessment and evaluation [50, 51] as outlined in Table 1.
Table 1.
Classification of learning disabilities based on response to intervention.
The model in Table 1 is a generic one which can be applied by others. How this has been applied in practice is described in the rest of this chapter with reference to a particular programme applying specific methods of assessment and treatment in a particular country context. As there are a number of different variables which can affect the development of reading, writing and spelling, the methods and materials used with each child vary, based on initial assessment to identify areas of strength and difficulty, as well as specific areas requiring intervention.
Intervention then takes place to address the variables related to the areas of difficulty. As this takes place, firm diagnosis and classification of learning disability then becomes possible, based on assessment linked to ongoing assessment and progress evaluation of the effects of multivariate treatment, based on use of particular types of methods and materials. Classification as learning disabled can then be linked to concessions to compensate for the areas of difficulty which have been demonstrated to be resistant to particular forms of treatment, as well as to ongoing treatment and learning support.
4. Initial assessment: focus on functional difficulties
The assessment process used in Dr. Charles Potter’s Reading Programme1 is based on the child’s family and scholastic history in either the private or government schooling system in South Africa, which is a country classified as both first and third world [52]. The assessment procedures conform to similar procedures used by other educational psychologists in South Africa to provide evidence which can be used for diagnostic purposes against what are termed the ICD DSM IV and ICD DSM V criteria by South African medical aid societies.2
The ICD DSM IV and ICD DSM V criteria are designed to enable initial diagnosis to be made against functional descriptions of the learning difficulties experienced by children. These can then be used as the basis for both functional classification as well as for the development of treatment programmes.
As has been described in a previous publication on the work of the programme [37], four screening tests are used at the outset of the assessment process. These are designed to yield information about reading single words and reading words in sequence, and writing and spelling single words and words in sequence. Results on these tests are then reported using reading, spelling and dictation ages, for the reason that the South African ICD DSM IV and DSM V are based on age-related expectancies which are then used by the medical aid societies for the management of claims and benefits.3
Besides following the medical aid society guidelines in focusing on basic skills in reading and written expression, the assessment procedures are also based on the procedures suggested by Luria [58] for clinical assessment of reading and writing. Qualitative analysis of an initial parent interview is combined with analysis of drawings, pragmatic writing-based tasks and observation in an initial ice-breaking session with the child. This is then followed by a second session with the child during which four screening tests are used to establish levels of basic skills in reading, writing and spelling. This information is also combined with additional evidence from a biographical inventory, parental interview, analysis of school reports and more formal psychometric testing. This includes assessment of arithmetical and mathematical problem-solving skills if these are highlighted as areas of difficulty by the child’s school and the child’s parents.
Overall, the procedures used in the assessment process thus follow Luria’s suggestion [58] that assessment should start with a preliminary conversation, and then include a careful history, detailed observation of behaviour, analysis of neurological symptoms and a series of additional objective tests. Luria suggests that the examination needs to be relatively short, and involve methods of experimental psychological investigation applied to clinical practice.
The methods of examination used in the initial sessions spent working with the child also include pragmatic assessment of repetitive and spontaneous speech, writing, reading, comprehension of texts and the solution of problems, in order to establish how reading, writing and spelling are used by the child as a functional system. This informal evidence is then combined with more formal testing of reading, writing and spelling skills, and interpreted, as Luria suggests, against a framework of knowledge of the types of difficulties normally associated with the functional system under investigation, based on current literature [59].
Assessment leads to a functional description of deficits sufficient for diagnosis of learning disability to meet medical aid requirements,4 as opposed to an attempt to link this to possible labelling of the child as dyslexic, or labelling in terms of the other types of learning disability commonly described in the literature [37]. This is consistent with the standpoint adopted by Elliott and Grigorenko [24] and Elliott [61], namely, that adding a label adds little of clarity to a functional description of deficits for purposes of intervention. Similarly, the pattern of scores on subtests of an IQ test would best be used functionally, to indicate areas of cognitive and language strength and weakness, as well as areas in sequencing and working memory which may need to be worked with in therapy.
5. Evidence-based multivariate treatment: a response to intervention model
Following Luria [62], the aim is to move from assessment to statement of areas of deficit, and from this to specific programmatic intervention. The statement of areas of deficit can then be used as the basis for diagnosis for medical aid purposes, recommendations concerning the need for additional more in-depth testing (e.g. cognitive testing, speech and language and/or visual assessment, more in-depth analysis of phonological and phonic skills) or for more in-depth neurological or paediatric investigation,5 as well as to recommend specific types of programmatic activities which can be used to address the areas of deficit.
Being based on the DSM IV criteria,6 the diagnosis is related to the ICD10 classifications of possible types of developmental disorders affecting the development of scholastic skills, which are as follows:
F81 Specific developmental disorders of scholastic skills
F81.0 Specific reading disorder
F81.2 Mathematics disorder
F81.8 Other developmental disorders of scholastic skills
F81.81 Disorder of written expression
F81.89 Other developmental disorders of scholastic skills
This classification then enables parents to be able to claim benefits from their medical aid societies. At the same time, the statement of areas of deficit then enables recommendations to be made for more in-depth testing, as well as for commencing treatment. This is done matching the behaviours tapped by the tests used in the assessment process with the functional descriptions associated with the following literature-based based categorisation of types of learning disability associated with the ICD 10 developmental disorders of scholastic skills [42, 64, 65]:
Dyslexia: learning difficulties affecting reading and related language-based processing skills.
Auditory processing problems: difficulties with the sound system of the language, with phonological awareness, with listening in the classroom, and with processing and remembering the sounds associated with the letters in reading, writing and spelling.
Language processing problems: difficulties in processing spoken language, affecting both receptive and expressive language.
Reading Comprehension Deficits: learning difficulties affecting an individual’s understanding of what they read.
Dysgraphia: learning difficulties affecting a person’s handwriting ability and fine motor skills.
Visual, Visual perceptual or visual motor deficits: poor eye-hand coordination, difficulties in navigating surroundings, difficulties in visual tracking of print or losing one’s place when reading.
Non-Verbal Learning Deficits: learning difficulties affecting the child’s social interactions, manifesting in difficulties interpreting nonverbal cues such as facial expressions or body language, or difficulties relating to poor coordination.
Dyscalculia: learning difficulties affecting a person’s ability to understand numbers and learn arithmetic or mathematical facts.
As the work done in my practice is related to the ICD 10 classification and medical aid codes, the functional difficulties associated with the ICD 10 codes related to the above categories (dyslexia, reading comprehension deficits, dysgraphia and dyscalculia) form the basis for the types of treatment initially developed for working with the child. Functional difficulties in the other four areas are referred to other therapists (e.g. occupational therapists, physiotherapists, visual therapists and speech and language specialists) working in the field.
This enables the work done in the practice to meet medical aid requirements, while at the same time focusing on use of particular methods and materials in working with reading, writing and spelling difficulties, difficulties with numeracy and mathematical problem-solving, as well as the attentional, emotional and social aspects which accompany difficulties at school (Table 2) [37, 38, 66].
Table 2.
Diagnosis of learning disability based on response to intervention prior to, during and subsequent to treatment.
The model for evidence-based classification can be represented as follows:
The model thus involves evidence-based multivariate treatment as the basis for firm classification of particular types of learning disability based on response to intervention over time. At each stage in the application of the model, classification of learning disability is based on incremental validity based on specific evidence relating to particular types of treatment. It is also related to the emotional, social, family and classroom issues involved in treating learning difficulties at school.
How the model has been applied in practice is outlined in the following sections. While this is done with reference to the multivariate programmes developed in the practice for treating learning disabilities, the model could also be applied in other programmes working in a similar evidence-based way.
6. Applying the model: treatment of reading difficulties
Dr. Charles Potter’s Reading Programme is a fluency-based programme for treating learning difficulties [67]. The methods used for treating reading difficulties in the programme are based on the theories of the Russian neuropsychologist A.R. Luria [58, 68, 69] and have been described in a number of previous publications [37, 38, 66, 70, 71]. The materials used in the programme are electronic, and can either be downloaded or sent out by email.
At pre-reading level, the material is activity-based and focuses on developing phonological and phonemic awareness. The methods used in working with the material are described in accompanying manuals [72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86] which can be used by parents, teachers and therapists, and form the basis for the training of programme implementers.
The programme works with children from pre-reading and school readiness level. The transition to foundation level is made once the child has developed alphabetic awareness and the associations between the letters of the alphabet and the sounds used to represent the letters in English. The child is then introduced to reading through a series of fifteen foundation level reading books, using a structured language experience approach which integrates reading, writing, phonics and spelling with drawing and illustration. This is done through six activity books based on families of rhyming words, which accompany the first six of the foundation level reading books, with the methods used described in accompanying manuals [75, 82, 86].
Once the child has developed the ability to read three letter words and words based on short vowel sounds and beginning and ending consonant blends and clusters, repetitive paired reading is introduced, focusing initially on reading of sentences. Comprehension is developed through drawing and illustration of reading content.
Once the child can read and write phonically based words as well as sentences using three letter words in context, reading fluency work is commenced using large print phonically based reading books, based on the model for treatment of reading acquisition, reading fluency and reading comprehension development represented in Table 3.
Table 3.
Model for Reading fluency development.
The procedures used are documented in a user’s manual which includes both theory and the methods used in programme implementation [72]. In addition, there is a parent implementer’s manual which presents a step by step approach to implementation [78].
7. Methods used for treatment of reading fluency difficulties
The development of the large-print, phonically based material used for developing reading fluency in the programme has been described in a separate publication [66]. The methods used for developing reading fluency involve use of a paired reading method called the 3 x 3 Oral Impress Method. This is designed to be used with a series of electronic reading fluency books which are graded, and written in a way which builds repetition into the words used, as well as phrases used in sentences.
The material presents letters and letter strings associated with particular sounds repetitively in an uncluttered format. Repetitive oral reading is then used together with visual tracking of the printed words to develop and then automatise the associations between the configuration of the letters within phonically regular words and their sounds as used in the written language the child sees, the spoken language the child hears, and the words read by both adult and child [87].
This is done by working with the reading material three paragraphs at a time in the following way (Table 4).
Paragraph One | Child reads | Parent and Child read together | Parent reads |
Paragraph Two | Parent reads | Child reads | Parent and Child read together |
Paragraph Three | Parent and Child read together | Parent reads | Child reads |
Table 4.
The 3 x 3 Oral impress method.
The aim, as Luria suggests [58, 68], is to enhance cerebral organisation based on a repetitive process. This was also Heckelman’s view when he pioneered the use of paired reading as a procedure [88, 89, 90], suggesting that paired reading is “one of the most direct and fundamental systems of reading” involving a “combination of reflexive neurological systems.” We have reported similar positive results [38, 66], supporting Heckelman’s position that gains made are based on increasing neurological integrity.
The model for developing using the phonically-based, large print reading materials to develop reading fluency would be conceptualised as based on the coding and recoding of phonic associations [91, 92, 93]. Following Dehaene [94, 95], what the 3 x 3 Oral Impress Method does when used with our phonically based large-print reading fluency books is to present the visual word form area in the brain with strings of letters representing sounds repeatedly. This would have the effect of strengthening the connections between the visual areas in the brain and the areas of the brain involved in processing sounds and oral language, thus enabling the child first to read, and then to read fluently.
8. Treating difficulties with rapid naming
The relationship between rapid naming and reading difficulties has been established by a number of researchers [96, 97, 98, 99, 100, 101, 102]. What has not been clearly established is whether rapid naming is a separate factor influencing reading performance, and whether it is responsive to training [103, 104]. Recent research indicates that training interventions in this area are possible [105, 106], but that more controlled studies are still necessary on whether rapid naming can be trained, and how it can be trained. The descriptions provided in this section should be viewed in this context.
Our methods focus on teaching rapid naming of letters, words and numbers, as well as teaching rapid reading. At initial stages in the programme, rapid naming of letters is conducted using phonogram cards. Rapid naming of words is conducted using key words drawn from our phonically-based large print reading material. Rapid naming of numbers is trained through rapid marking of arithmetic worksheets. Rapid reading is also taught developmentally using the 3 x 3 Oral Impress Method [72], which focuses on accurate naming of phonically regular words and sentences, and then on rapid and accurate reading of a wider range of reading material.
The material used is phonically graded as well as repetitive, and the aim in the initial stages is to work with words which become increasingly familiar to the child, to develop accurate and rapid naming ability for individual words and words in sequence. This is done through the repetitive methods used to develop automaticity in reading [74], as well as through activities in which the child is asked to name letters and numbers in worksheets based on both familiar and unfamiliar content. Tachistoscopic work is then introduced at later stages in the programme [107], working repetitively with words of increasing length drawn from an electronic dictionary, as well as with words drawn from graded revisualisation materials and the child’s school books.
Using computer-based presentation, length of words presented, time exposure of the presentation of each word and time between the exposure of each word can be treated as variables. Other variables involve the ways in which words can be presented, read, revisualised and written down, following the procedures outlined in Table 5.
Table 5.
Methods for treating rapid naming difficulties.
The methods used for developing rapid naming in the child’s programme thus link with the methods used for training fluency in reading, and include activities methods designed to develop rapid naming of words as well as activities aimed at developing increasing familiarity with words. Based on Luria’s theories of automaticity [58], repetition would be intrinsic to the development of fluency in reading. As Dehaene [95] has noted, familiarity with material influences fluency. The aim of our methods is to use repetitive paired reading to develop the coding, recoding, working memory and rapid naming abilities necessary for fluent and accurate reading, and for self-teaching [108].
9. Developing automaticity in writing and spelling
Fluency in writing and spelling is addressed in our programme through a variety of methods involving linking the teaching of phonic associations with training in basic skills in writing and copying. This is done by teaching the child how to work from print to sound, how to analyse words based on phonic analysis of how words work, and how to use the letters and letter combinations used to represent the vowels in words as the basis for remembering how words are spelled both individually and in sequence. This is done through a process we call “phonological referencing” which focuses on the coding and recoding of phonic associations [80].
This is done using word families of between five and six words, supported by sentences in which the words are analysed in sequence, revisualised and then tested. The aim is to use revisualisation of words and sequences of words as an integral part of the process of learning to write and spell, with the aim of developing the phonological, phonic and sequential working memory processes involved in writing rapidly and accurately in sequence [84, 85].
The model for using our phonically-based, large print materials for developing writing and spelling fluency, is represented in Table 6.
Table 6.
Model for developing writing and spelling fluency based on activities involving development of reading, writing, spelling, phonic analysis and revisualisation.
Following Luria’s theories [58], our methods use repetition as intrinsic to the development of automaticity in writing and spelling fluency. As with reading fluency, the aim is to develop the coding, recoding and working memory abilities necessary for fluent and accurate writing and spelling [91, 92, 93, 108, 109].
At initial stages in the programme, the aim is to build phonological, orthographic and morphological awareness through phonological referencing [86]. This involves developing the child’s phonic analysis, visual memory and sequential working memory skills by methods which combine phonic analysis and revisualisation [74].
The phonic abilities of the child are established from analysis of the child’s errors on spelling tests, in the child’s descriptive writing, creative writing and school work, as well as through a series of phonic inventories [79]. Based on the pattern of errors, we initially involve the child in work with word families and phonogram cards targeting specific phonic errors in the profile. In the process, the child is introduced to working with the Seven Vowel Phonic Analysis System, which is a procedure for teaching children through activities involving mapping the combinations of letters used in writing words to the sounds made when those words are spoken orally [73, 74].
The aim is to combine phonic analysis and revisualisation in developing skills in word attack, spelling and sequential working memory. This is done through activities focusing on analysis of the letters and letter combinations used to represent the vowel sounds in words, combined with revisualisation activities focused on remembering sequences of words [84]. The sequence of instruction followed, and the links between phonological referencing, the introduction and application of the Seven Vowel Phonic Analysis System, and the combination of phonic analysis and revisualisation in the Targeted Revisualisation Programme [83], are represented in Table 7 below.
Table 7.
Introducing phonological referencing and the seven vowel phonic analysis system.
The sequence of instruction followed in implementing the programme thus integrates reading, writing and spelling through activities which are phonically-based, linking phonological, phonemic, visual memory and sequential working memory development. The methods used are outlined in a series of manuals which can be used by therapists, teachers, schools and parents [81, 82, 83, 84, 85].
10. Mapping the associations between spoken and written words
Both phonological referencing and the Seven Vowel Phonic Analysis System are used for point to point analysis of the links between the sequences of letters used in written words and the sequence of sounds made which the words are spoken orally. This is done through activities in which the child is taught to map the associations between the sequences of letters used in written words and the sequences of sounds used when the words are spoken orally [80].
The sequence of instruction followed in teaching the child is as follows:
After the child has learned the associations between sounds and letters, the child works with word families as well as with phonogram and rime cards, which are used side by side with the process of phonological referencing. The basis for mapping is to link the individual letters and sequences of letters with the sequences of sounds made when the words are spoken out loud, based on the principle that “what we say is what we write.”
This stage involves activities in which the hand is placed under the chin to increase the ease by which the vowel sounds in words can be identified as part of the process of mapping letters to sounds and sounds to letters.
Particular focus is placed on identifying the vowel sounds in words (which are spoken when the mouth opens) and the consonant sounds (which are spoken when the mouth closes). The letters the child has written or typed form the departure point for linking what is written on paper with both sounds and mouth movements.
The aim is to enable the child to identify the vowel letters and the consonant letters used in written words, and then to link these back to the sounds made when the word is spoken orally.
Reverse mapping between the sequence of sounds in the word and the letters used in writing the word then takes place. Once the vowel sound in the word has been identified, the letters used to represent the vowel sound are then colour coded. In the process, short vowel sounds are identified as normally being made by one letter working by itself, while long vowel sounds are identified as normally being made by two letters working together.
As the focus lies on mapping the consistency between the sequences of letters used in written words with the sequences of sounds used when the words are spoken orally, the aim is to enable the child to build the variety of phonic associations necessary to read, write and spell in sequence. Visual memory, revisualisation and dictation activities are also used to develop the metacognitive and working memory processes necessary to remember and write sounds and letters in sequence, and words in sequence [110, 111, 112, 113, 114, 115, 116].
11. Increasing the transparency of written English
Much has been written about the transparency of the English language compared to other languages [117, 118, 119, 120, 121, 122], for the reason that the phonic associations underpinning English orthography are varied, with similar sounds being represented by different letter combinations. This means that both reading and spelling in English are not as easy for children to learn as in many other languages such as Italian, Afrikaans, Welsh, German, or French [123, 124, 125, 126, 127, 128, 129, 130]. This has potentially negative effects on the progress of children with learning disabilities [118, 119, 131, 132, 133].
Our materials attempt to overcome this problem at initial stages in the programme through the use of carefully chosen vocabulary. Phonic associations are initially taught through graded rhyming word activities, and then developed through activities involving reading, writing and use of working memory in spelling. Once the child has been introduced to the phonological referencing and colour coding process with individual words and families of rhyming words, he or she is also introduced to activities involving use of visual memory and revisualisation of words in sequence.
Word families of written words are used as the basis for analysing individual words, while written sentences are used as the basis for analysing words in sequence. This is done through activities based on sentences and paragraphs which include words in which the y and w combine with other letters to form long vowel sounds. These letter-sound associations are identified and then mapped using the Seven Vowel Phonic Analysis System [73, 74, 83].
In the process, the child is taught that a, e, i, o and u are the letters normally used to represent the vowel sounds in words, but that y and w can also be used to represent the represent the vowel sounds in positions at or near the end of written words in English. The Seven Vowel Phonic Analysis System is then worked with and applied through activities in which the child speaks the word out loud and then identifies the letters used as vowels in the word. Through activity-based learning, the child is introduced to the principle that there needs to be a vowel in every word, that the letters a, e, i, o and u are used to represent the vowels in all positions in words, and that the use of y and w as vowels at the end of words is both logical and consistent, applying to nearly all words in English.
The use of the Seven Vowel Phonic Analysis System thus enables the letters used to represent the sounds in both simple and complex written words to be identified through phonological referencing, and to be analysed following the principle that “what we say we write.” The aim is make written English as transparent as written Welsh, in which the use of the seven vowels a, e, i, o, and u, as well as y and w, also applies [122, 123, 133], making it logical and easier for children to learn.
12. Combining phonic analysis and revisualisation in developing sequential working memory for words
The methods for teaching spelling in our programme have been described in Potter [38, 70] and follow the phonologically and phonically-based stages in spelling described by Moats [134, 135], as well as the stages in a set of three phonic inventories based on the foundation level curriculum taught in primary schools in South Africa [79]. Phonic associations are initially introduced through graded rhyming word activities involving reading, writing and use of working memory in spelling. Focus is placed on teaching through synthetic phonic approaches incorporating teaching children to isolate sounds and blend sounds into words, as well as how to create families of rhyming words based on similar phonological and phonemic elements [75].
These are introduced side by side with reading fluency activities using our foundation level and then our basic level readers, through methods which use activity-based learning to build the variety of phonic associations necessary to read, write and spell. Phonic analysis is then introduced using phonological referencing [80], which is applied working with families of between five and seven words, each of which are based on a similar consonant blend of cluster. These are then contextualised in short sentences in which the words are then phonically analysed and revisualised in sequence. The aim is to develop the working memory integrities necessary to write accurately in sequence.
In the ck word family, for example, the following words would be written in the child’s writing book.
shock
brick
check
stack
cluck
trick
The vowel in each word would then be underlined in colour and matched with the way the mouth opens in making each vowel sound and the way the mouth closes in making each consonant sound. After this, the child would work with his or her reading partner and phonologically reference each word in the ck word family, by linking the sounds in each word when the word is spoken out loud with the letters used when the word is written down.
This would be done through an activity-based process, in which the child is asked to:
Point to the written word on the page and say it.
Look at the two letters at the beginning of the written word. Say the sound of these letters out loud.
Look at the vowel in the middle of the written word. Say the sound of this letter out loud.
Look at the two letters at the end of the written word. Say the the sound of these letters out loud.
The phonic rule applied in each of the words would then be focused on working with the reading partner. This would be done by focusing on how the beginning sound, the middle sound and the ending sound work together to make each word, and how the ck ending applies in each word.
Each of the words in the family would then be contextualised in sequence in a short sentence. The sentence would be written down by the child, and the vowel or vowels in each word in the sentence underlined in colour. After this, each word in the sentence would then be revisualised in sequence working memory tested by asking the child to rewrite the sentence from memory. These sequential revisualisation techniques would then be used further at higher levels in the programme [84].
13. Linking the development of phonic associations, visual memory and sequential working memory skills
The sequence of instruction followed with each child varies based on evidence of how the child learns, but is conducted with the aim of linking the development of phonic analysis, visual memory and working memory skills as represented in Table 8.
Table 8.
Methods linking phonic analysis, visual memory for strings of letters and words and sequential working memory for written words, phrases, sentences and paragraphs.
It will be apparent from Table 8 that the aim at each level of the programme is to work to combine phonological and phonic skills development with the development of visual memory and sequential working memory. This is done through methods which to combine the process of phonic analysis with the process of revisualisation in developing sequential working memory for words [83, 84], through a longitudinal process in which:
The child is taught to map the associations between the sequences of letters used in words and the sequences of sounds used when words are spoken orally through phonological referencing, as well as through use of phonogram and rime cards.
The child is taught that each written word is logical and can be analysed on the principle that “what we say is what we write.”
The child is shown how to use revisualisation to remember the sequences of letters used in individual words and the sequences of words in used in sentences.
Both phonic analysis and revisualisation are thus used to develop the child’s ability to store each word in working memory in sequence. This is initially done working with words in the context of sentences, and then with sequences of sentences. The child’s sequential working memory is tested through dictation.
At each level in the programme, the methods used are repetitive and follow the procedures for developing automaticity outlined by Luria [58, 68, 69], and are summarised in illustrated implementer manuals for users [74, 81, 83, 84, 85]. Once the child is able to recall sentences of between five and seven words accurately, span of sequential working memory is increased by phonic analysis and revisualisation of sentences of increasing length, as well as by phonic analysis and revisualisation of increasing numbers of sentences in sequence.
As our reading fluency materials are graded and phonically based, sentences and paragraphs from these can be used as the basis for activities which link reading, writing, spelling and sequential working memory work. More complex graded paragraphs and sequences of paragraphs are then introduced once the Targeted Analysis, Revisualisation and Sequential Spelling Programme is commenced, as described in the section following.
14. The targeted analysis, revisualisation and sequential spelling programme
Once the child is able to recall the words used in individual sentences and sequences of sentences accurately, the materials used in the Targeted Analysis, Revisualisation and Sequential Spelling Programme are introduced. The methods target words with more than one vowel, which are first written, then typed, then colour coded and then syllabified. The target words are then revisualised and tested [136].
After analysing and recalling the target words, the text of the graded materials is then worked with, focusing on each word in each sentence in sequence. Sequential revisualisation techniques are used. We call this process “targeted revisualisation” as each word is targeted in sequence, using techniques which combine the procedures used for phonic analysis of the target words with the types of mental imagery the child uses in recalling words. These build on the activities linking phonic analysis and revisualisation, and the methods used for developing sequential working memory used at previous levels in the programme.
The aim is to use accuracy in use of sequential working memory for words as the basis for developing fluency and automaticity in writing and spelling [38]. This is done in four stages, as outlined in Table 9.
Level of mediation | Focuses of phonic analysis | Focuses of revisualisation | Focuses of use of sequential working memory |
---|
Stage One: Focus on Words based on Short Vowel Sounds | Introduce concept that vowels are used in all spoken and written words. Identify and mediate short vowel sounds a, e, i, o, and u. | Construct, deconstruct, mentally image and revisualise words and rhyming word families containing short vowel sounds. | Use working memory in writing rhyming words based on short vowel sounds in sequence. |
Stage Two: Focus on Words based on Long Vowel Sounds | Identify and mediate long vowel sounds involving use of digraphs involving a, e, i, o, and u. Introduce the letters y and w as vowels in positions at or near the end of words. | Construct, deconstruct, mentally image and revisualise words and rhyming word families containing long vowel sounds, including use of the letters y and w as vowels in positions at or near the end of words. | Use working memory in writing sequences of words containing both long and short vowel sounds, including use of the letters y and w as vowels in positions at or near the end of words. |
Stage Three: Focus on Sequentialisation of Words in Sentences | Identify letters used as vowels in words used in sequence in sentences. | Identify, phonically analyse, mentally image and revisualise single syllable and polysyllabic words in sequence in sentences. | Use working memory in writing single syllable and polysyllabic words in sequence in sentences and sequences of sentences. |
Stage Four: Focus on Sequentialisation of Words and Sentences in Paragraphs | Identify letters used as vowels in words used in sequence in sentences, and in sentences used in sequence in paragraphs. | Identify, phonically analyse, mentally image and revisualise single syllable and polysyllabic words in sequence in paragraphs. | Use working memory in writing sentences in sequence in paragraphs of increasing length and phonic complexity. |
Table 9.
Stages and focuses of mediation in the targeted analysis, revisualisation and sequential spelling programme.
The Targeted Analysis, Revisualisation and Sequential Spelling Programme is applied using graded paragraphs, which increase in complexity as well as length. As these are worked with, the process of combining phonic analysis and revisualisation in using the Seven Vowel Phonic Analysis System is applied repetitively. This is done by working from printed word to sound, and from sound back to print. These phonological recoding skills provide the building blocks on which writing and spelling fluency is developed [71].
On a phonological and phonic level, the methods used are based on the coding and recoding of phonic associations through activities in which the child writes, types and colour codes the vowels in words by underlining the letters used to represent the vowel sounds in colour as well as using the colour coding feature in a word processing programme. This adds a visual dimension to the targeted revisualisation process, as the methods used are designed to make the letters used to represent the vowel sounds in words stand out in colour [83].
Both phonic associations and visual contrasts are then used to identify the letters representing the vowel sounds in words, with the aim of enabling the child to develop working memory for individual words as well as sequential working memory for words in sequence. Fluency in writing and spelling is then based on increasing span of sequential working memory as well as automaticity in recalling the sequences of letters used in individual words, the sequences of words used in sentences, and the sequences of sentences used in paragraphs.
At higher levels in the programme, rapid reading of words and working memory for words are also developed through use of tachistoscopic methods conducted side by side with targeted revisualisation [107]. Children who have worked in this way report effects in improving word attack in reading, as well as improvements in rate of processing words, rate of reading, spelling accuracy and rate of work.
15. Treatment of difficulties with calculation and numerical problem-solving
In addition to the strands in the child’s programme focused on treating difficulties with reading, writing and spelling, numerical and problem-solving activities are also included in the programme, using electronic materials which can be worked with online, as well as sent to parents and children by email [71]. The aim of using this format-based multivariate treatment system is to enable treatment of the functional difficulties identified in assessment, while at the same time addressing needs indicated by the errors made by the child in his or her school work.
The format system is flexible and comprehensive enough to be able to focus on areas of strength as well as needs, while also enabling email delivery of the activities included in each child’s individual programme. Number concept development can also be linked to language and problem-solving activities, with support programmes linked to the developmental model outlined in Table 10. These activities are then implemented side by side with the mathematical curriculum taught at school.
Table 10.
Model for development of number concept, numerical fluency, numerical reasoning and numerical problem solving.
It will be apparent from Table 10 that at the same time as treating numerical and mathematical difficulties identified in the initial assessment, the learning support provided is both diagnostic and based on clinical teaching, as well as linked to numerical and mathematical concepts covered in the child’s work at school. As with other areas of our programme, the aim is to treat functional difficulties as well as to evaluate the child’s response to specific types of interventions, as outlined in the section following.
16. Progress evaluation
Work with each child is conducted longitudinally, and is based on a cycle in which evaluation forms an integral part of both planning and implementation. Feedback on specific activities in the format is also provided by photographs sent by email or WhatsApp, enabling the planning of the next format in the child’s programme to be evidence-based, linked to ongoing evaluation of learning needs. Assessment is then built into programme implementation at regular intervals.
The model used for implementation is action research based [137, 138, 139], and can be summarised as follows (Table 11).
Table 11.
Action research cycle for planning and implementation of activity-based online programmes.
As the programme’s data base is extensive, the planning and implementation model implies that each child’s programme is evidence-based and multivariate, addressing a number of different learning needs through use of a variety of graded activities. The programme is then implemented using online sessions supported by learning materials provided by email [71].
The aim is that programme implementation can take place with support from parents, teachers, tutors or au paires as reading partners, working with a variety of electronic materials delivered by email or made accessible online via links to websites. Methods used in the programme are documented in illustrated implementer manuals, and are demonstrated working online, supported by cell phone and email contact.
Both evaluation programme activities and evaluation of progress are linked to evidence from the child’s school work and school reports at regular points in primary, with full re-assessment and summative evaluation being conducted at point of transition to high school. The aim at this point is to make a firm diagnosis of learning disability which can be linked to concessions.
The aim is to ensure that firm classification and labelling of a child as learning disabled is valid [36], based both on longitudinal analysis of test results as well as response to specific interventions [140, 141], on the model described in the section following.
17. Firm classification of particular types of learning disability on the basis of response to intervention
In implementing the different types of interventions which have been described in this chapter, the programme focuses on a number of different variables related to the areas of difficulty. Interventions are normally longitudinal and conducted side by side with the curriculum taught in the child’s school.
The programme works with the aim of providing fluency-based interventions which can develop basic skills and competences in reading, writing, spelling as well as numeracy. At the same time, evidence-based learning support is provided focused on areas of the school curriculum with which the child is experiencing difficulties. This type of multivariate intervention is implemented using formats based on an online session providing counselling followed by an intervention, supported by electronic materials which can then be used by parents and children working in conjunction with a teacher or therapist, or independently [71].
At the outset the child’s difficulties are described functionally. This enables labelling to be avoided, until such time as the child has had benefit of focused multivariate treatment, and is also likely to be more developmentally and neurologically mature [142, 143, 144, 145]. As maturation takes place, firm diagnosis and classification of learning disability then becomes to the child’s benefit, as it can be linked to concessions related to areas of ongoing difficulty. This can be linked both to cross-sectional assessment as well as evaluation of response to interventions which have been based on multivariate treatment using particular types of methods and materials.
In our programme, firm classification as learning disabled is thus normally undertaken at the end of a child’s primary school years, based on evidence collected by use of different methods over time [146, 147], within a model of inference based on a process of incremental validity [34, 35, 148]. Diagnosis can then be linked to concessions to compensate for those areas of difficulty which have been demonstrated to be resistant to particular forms of treatment, as well as to ongoing treatment and learning support in particular areas of the high school curriculum.
The model for classification of learning disabilities is reflected in Table 12 on the previous page. It will be noted that the model is multimethod, based on summative assessment linked to progress evaluation of longitudinal interventions conducted across a number of areas of functional difficulty, enabling triangulation across different data points over time [131].
Table 12.
Classification of learning disabilities based on response to multivariate fluency-based interventions.
This enables firmer conclusions as to the type of learning disability involved, as well as classification of learning disability based on specific evidence relating to response to particular types of treatment [141].
18. Summary and implications
This chapter has focused on treatment of the functional learning difficulties associated with dyslexia, dysgraphia and dyscalculia, as three dimensions of learning disability. As each of these dimensions can be associated with a range of reading, writing, spelling and working memory difficulties, the model of classification described in this chapter has been described with reference to a particular programme which uses a large data base to implement a variety of different activities with children diagnosed as having learning problems.
Owing to the measurement error implicit in testing young children who may have attention and focus difficulties in addition to functional difficulties with reading, writing, spelling and maths, the model of classification assumes that initial diagnosis of learning disabilities is at best provisional. For this reason, labelling of children is avoided at the outset. Functional indicators based on actual versus expected performance are used in preference, using ICD10 codes and descriptors as opposed to labelling using terms such as Dyslexia, Auditory Processing Problems, Language Processing Problems, Reading Comprehension Deficits, Dysgraphia, Visual Perceptual or Visual Motor Deficits, Non-Verbal Learning Deficits or Dyscalculia.
Detailed description of the initial assessment process has been provided in order to show that functional ICD 10 descriptors can be used instead of labels as the basis for establishing needs and areas of treatment. Treatments can then be targeted at these descriptors, being related to focus on specific problems with reading, writing and spelling, as well as numerical concepts and mathematical problem-solving. Difficulties outside these areas are then referred to other specialists.
Detailed description of particular methods, materials and programmes has also been provided in this chapter to indicate that once initial functional classification has taken place linked to specific areas of difficulty, multivariate interventions can then be developed and implemented. Firm classification then becomes possible based on the child’s progress over time.
One implication is that initial diagnosis of learning difficulties can be rigorous despite being provisional, providing detailed descriptions of specific areas of difficulty which are made with a view to undertaking multivariate treatment. Firm classification can then be made based on response to intervention at a time in the child is likely to be more developmentally and neurologically mature, and prior making a transition to new forms of teaching and new areas of learning at high school level.
Another implication is that the process of establishing firm diagnosis and classification would best be conducted at the end of a child’s primary school years, with a view to establishing concessions as well as the possibility of further treatment at higher levels in the curriculum. At this point firm diagnosis as having dyslexia, dysgraphia or dyscalculia can act to the child’s maximal benefit, in maximising the chances of obtaining the concessions and further treatments necessary to making the grade.
As the response to intervention classification model described in this chapter has been successfully applied in practice,7 a third implication is that the model is feasible and may have wider relevance. It offers the possibility that firm classification as learning disabled can be based on the child’s response to treatment which has been focused, multivariate and multimethod. In terms of the model, firm diagnosis of children as dyslexic, dysgraphic or dyscalculaic becomes an outcome taking place after treatment, linked to the possibility of concessions as well as additional interventions.
\n',keywords:"dyslexia, dysgraphia, dyscalculia, reading, writing, spelling, numeracy, working memory, assessment, evaluation, response to intervention, incremental validity; multivariate treatment",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/79900.pdf",chapterXML:"https://mts.intechopen.com/source/xml/79900.xml",downloadPdfUrl:"/chapter/pdf-download/79900",previewPdfUrl:"/chapter/pdf-preview/79900",totalDownloads:152,totalViews:0,totalCrossrefCites:0,dateSubmitted:"August 22nd 2021",dateReviewed:"October 11th 2021",datePrePublished:"January 5th 2022",datePublished:"March 30th 2022",dateFinished:"January 5th 2022",readingETA:"0",abstract:"This chapter provides a model for classification of dyslexia, dysgraphia and dyscalculia through analysis of the response of children to treatment. The model is discussed with reference to the types of multivariate treatment applied in a particular programme which works interactively online using an electronic data-base for linking functional difficulties in learning to treatment, and through this to firm diagnosis and classification. In applying the model, initial diagnosis of learning disabilities is treated as provisional, based on functional indicators as well as test data. Firm classification becomes possible through longitudinal assessment, analysis of response to multivariate intervention as well as response to specific programmes. Diagnosis can then be linked both to concessions as well as ongoing treatment.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/79900",risUrl:"/chapter/ris/79900",signatures:"Charles Potter",book:{id:"10910",type:"book",title:"Learning Disabilities",subtitle:"Neurobiology, Assessment, Clinical Features and Treatments",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",publishedDate:"March 30th 2022",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/10910.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-588-0",printIsbn:"978-1-83968-587-3",pdfIsbn:"978-1-83968-589-7",isAvailableForWebshopOrdering:!0,editors:[{id:"103586",title:null,name:"Sandro",middleName:null,surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"93190",title:"Dr.",name:"Charles",middleName:null,surname:"Potter",fullName:"Charles Potter",slug:"charles-potter",email:"pottercs@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93190/images/6641_n.jpg",institution:{name:"University of the Witwatersrand",institutionURL:null,country:{name:"South Africa"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Classification of learning disabilities",level:"1"},{id:"sec_3",title:"3. Functional description of different types of learning difficulties: a response to intervention perspective",level:"1"},{id:"sec_4",title:"4. Initial assessment: focus on functional difficulties",level:"1"},{id:"sec_5",title:"5. Evidence-based multivariate treatment: a response to intervention model",level:"1"},{id:"sec_6",title:"6. Applying the model: treatment of reading difficulties",level:"1"},{id:"sec_7",title:"7. Methods used for treatment of reading fluency difficulties",level:"1"},{id:"sec_8",title:"8. Treating difficulties with rapid naming",level:"1"},{id:"sec_9",title:"9. Developing automaticity in writing and spelling",level:"1"},{id:"sec_10",title:"10. Mapping the associations between spoken and written words",level:"1"},{id:"sec_11",title:"11. Increasing the transparency of written English",level:"1"},{id:"sec_12",title:"12. Combining phonic analysis and revisualisation in developing sequential working memory for words",level:"1"},{id:"sec_13",title:"13. Linking the development of phonic associations, visual memory and sequential working memory skills",level:"1"},{id:"sec_14",title:"14. The targeted analysis, revisualisation and sequential spelling programme",level:"1"},{id:"sec_15",title:"15. Treatment of difficulties with calculation and numerical problem-solving",level:"1"},{id:"sec_16",title:"16. Progress evaluation",level:"1"},{id:"sec_17",title:"17. Firm classification of particular types of learning disability on the basis of response to intervention",level:"1"},{id:"sec_18",title:"18. Summary and implications",level:"1"}],chapterReferences:[{id:"B1",body:'[Hinshelwood J. Congenital word blindness. The Lancet. 1900:1506-1508]'},{id:"B2",body:'[Morgan WP. A case of congenital word blindness. British Medical Journal. 1896;1378]'},{id:"B3",body:'[Orton ST. “Word-blindness” in school children. Archives of Neurology and Psychiatry. 1925;5:581-615]'},{id:"B4",body:'[Orton ST. Reading, Writing and Speech Problems in Children. New York: Norton; 1938]'},{id:"B5",body:'[Dearborn WF. The psychology of reading: An experimental study of the reading pauses and movements of the eye. In: Archives of Philosophy, Psychology and Scientific Methods. New York: Columbia University, The Science Press; 1906. p. 4]'},{id:"B6",body:'[Dearborn WF. Experiments in learning. Journal of Educational Psychology. 1910;1(7):373-388]'},{id:"B7",body:'[Monroe M. Children Who Cannot Read. Chicago: University of Chicago Press; 1932]'},{id:"B8",body:'[Gates AI. The Improvement of Reading. 3rd ed. New York: Macmillan; 1947]'},{id:"B9",body:'[Durrell DD. Improvement of Basic Reading Abilities. Chicago: World Book; 1940]'},{id:"B10",body:'[Fernald GM. Remedial Techniques in Basic School Subjects. New York: McGraw-Hill; 1943]'},{id:"B11",body:'[Gillingham A, Stillman B. Remedial Teaching for Children with Disability in Reading, Spelling, and Penmanship. Cambridge MA: Educator\'s Publishing Service; 1968]'},{id:"B12",body:'[Strauss AA, Lehtinen LE. Psychopathology and Education of the Brain-Injured Child. New York: Grune & Stratton; 1947]'},{id:"B13",body:'[Cruickshank W. A Teaching Method for Brain-Injured and Hyperactive Children. Syracuse, NY: Syracuse University Press; 1961]'},{id:"B14",body:'[Ayres JA. The development of perceptual motor abilities: A theoretical basis for treatment of dysfunctions. American Journal of Occupational Therapy. 1963;17:221-225]'},{id:"B15",body:'[Dubnoff B. The practical application of an integrated perceptual motor program in a school for children with severe learning disabilities: A preliminary report. In: Selected Convention Papers: New Frontiers in Special Education. Council for Exceptional Children, Arlington, Va. Papers presented at the Annual CEC Convention (43rd, Portland, Oregon, April 20–24). 1965. pp. 194-199]'},{id:"B16",body:'[Frostig M. Education of children with learning disabilities. In: Frierson EC, Barbe WB, editors. Educating Children with Learning Disabilities. New York: Appleton-Centurey-Crofts; 1967. pp. 387-398]'},{id:"B17",body:'[Kephart NC. Perceptual-motor aspects of learning disabilities. Exceptional Children. 1964;31(4):201-206]'},{id:"B18",body:'[Getman GN, Kane ER, Halgren MR, McKee GW. Developing Learning Readiness. Manchester, MO: Webster Division, McGraw-Hill; 1968]'},{id:"B19",body:'[Kirk SA, Bateman B. Diagnosis and remediation of learning disabilities. Exceptional Children. 1962;29(2):73-78]'},{id:"B20",body:'[Spalding RB, Spalding WT. The Writing Road to Reading. New York: Morrow; 1957]'},{id:"B21",body:'[Freidus E. Methodology for the classroom teacher. In: Helmuth J, editor. The Special Child in Century 21. Seattle: Special Child Publications; 1964]'},{id:"B22",body:'[Johnson DJ, Myklebust HR. Learning Disabilities; Educational Principles and Practices. New York: Grune and Stratton; 1967]'},{id:"B23",body:'[Chall J. Learning to Read: The Great Debate: An Inquiry Into the Science, Art and Ideology of Old and New Methods of Teaching Children to Read. New York: McGraw-Hill; 1967]'},{id:"B24",body:'[Elliott JG, Grigorenko EL. The Dyslexia Debate. Vol. 14. New York: Cambridge University Press; 2014]'},{id:"B25",body:'[Elliott JG, Nicolson R. Dyslexia: Developing the Debate. London: Bloomsbury; 2016]'},{id:"B26",body:'[Adams MJ. Beginning to Read: Thinking and Learning about Print. Cambridge, MA: MIT Press; 1990]'},{id:"B27",body:'[National Reading Panel (US), National Institute of Child Health, & Human Development (US). Report of the National Reading Panel: Teaching Children to Read: An Evidence-Based Assessment of the Scientific Research Literature on Reading and its Implications for Reading Instruction: Reports of the Subgroups. National Institutes of Health: National Institute of Child Health and Human Development; 2000]'},{id:"B28",body:'[Ehri LC. Learning to read words: Theory, findings and issues. Scientific Studies of Reading. 2005;9:167-188]'},{id:"B29",body:'[Shaywitz BA, Fletcher JM, Shaywitz SE. Defining and classifying learning disabilities and attention-deficit/hyperactivity disorder. Journal of Child Neurology. 1995;10, 1:S50-S57]'},{id:"B30",body:'[Lyon GR, Fletcher JM, Barnes MC. Learning disabilities. In: Mash EJ, Barkley RA, editors. Child Psychopathology. New York: Guilford Press; 2003. pp. 520-586]'},{id:"B31",body:'[Fuchs D, Mock D, Morgan PL, Young CL. Responsiveness-to-intervention: Definitions, evidence, and implications for the learning disabilities construct. Learning Disabilities Research & Practice. 2003;18(3):157-171]'},{id:"B32",body:'[Vaughn S, Fuchs LS. Redefining learning disabilities as inadequate response to instruction: The promise and potential problems. Learning Disabilities Research & Practice. 2003;18(3):137-146]'},{id:"B33",body:'[Fletcher JM, Vaughn S. Response to intervention: Preventing and remediating academic deficits. Child Development and Perspectives. 2009;1:30-37]'},{id:"B34",body:'[Haynes SN, Lench HC. Incremental validity of new clinical assessment measures. Psychological Assessment. 2003;15(4):456-466]'},{id:"B35",body:'[Hunsley J, Meyer GJ. The incremental validity of psychological testing and assessment: Conceptual, methodological, and statistical issues. Psychological Assessment. 2003;15(4):446-455]'},{id:"B36",body:'[Fuchs LS, Fuchs D. Treatment validity: A unifying concept for reconceptualizing the identification of learning disabilities. Learning Disabilities Research and Practice. 1998;13:204-219]'},{id:"B37",body:'[Potter CS. Developing automaticity in children with learning disabilities: A functional perspective part one: Theory and assessment. In: Ryan C, editor. Learning Disabilities. London: InTech; 2017a Available from: https://www.intechopen.com/books/learning-disabilities-an-international-perspective/developing-automaticity-in-children-with-learning-disabilities-a-functional-perspective-part-one-the]'},{id:"B38",body:'[Potter CS. Developing automaticity in children with learning disabilities: A functional perspective part two: programme methods and materials. In: Ryan C, editor. Learning Disabilities. London: InTech; 2017b Available from: http://www.intechopen.com/articles/show/title/developing-automaticity-in-children-with-learning-disabilities-a-functional-perspective-part-two-pro]'},{id:"B39",body:'[Vaughn S, Wanzek J, Fletcher JM. Multiple tiers of intervention: A framework for prevention and identification of students with reading/learning disabilities. In: Taylor BM, Ysseldyke JE, editors. Effective Instruction for Struggling Readers. K-6 ed. New York: Teachers College Press; 2007. pp. 173-195]'},{id:"B40",body:'[Lyon GR, Fletcher JM, Shaywitz SE, Shaywitz BA, Torgesen JK, Wood FB. Rethinking Learning Disabilities. Washington, DC: Hudson Institute; 2001]'},{id:"B41",body:'[Fletcher JM. Dyslexia: The evolution of a scientific concept. Journal of the International Neuropsychological Society. 2009;15(4):501-508]'},{id:"B42",body:'[Fletcher JM. Classification and identification of learning disabilities. In: Wong B, Butler DL, editors. Learning about Learning Disabilities. Cambridge, MA: Elsevier Academic Press; 2012. pp. 1-25]'},{id:"B43",body:'[U.S. Office of Education. First Annual Report of the National Advisory Committee on Handicapped Children. Washington, DC: U.S. Department of Health, Education, and Welfare; 1968]'},{id:"B44",body:'[Fletcher JM, Lyon GR, Fuchs LS, Barnes MA. Learning Disabilities: From Identification to Intervention. New York: Guilford Publications; 2018]'},{id:"B45",body:'[Cox DD. Evidence-based interventions using home-school collaboration. School Psychology Quarterly. 2005;20(4):473-497]'},{id:"B46",body:'[Stuebing KK, Fletcher JM, Branum-Martin L, Francis DJ, Van Der Heyden A. Evaluation of the technical adequacy of three methods for identifying specific learning disabilities based on cognitive discrepancies. School Psychology Review. 2012;41(1):3-22]'},{id:"B47",body:'[Potter CS. Programme evaluation. In: Terreblanche M, Durrheim K, editors. Research Methodology in the Social Sciences in Southern Africa. 2nd ed. Cape Town: University of Cape Town Press; 2006. pp. 209-226]'},{id:"B48",body:'[Information on Dr Charles Potter’s Reading Programme can be obtained by clicking on the following link: http://www.charlespotter.org]'},{id:"B49",body:'[Flanagan DP, Ortiz SO, Alfonso VC, Dynda AM. Integration of response to intervention and norm-referenced tests in learning disability identification: Learning from the tower of Babel. Psychology in the Schools. 2006;43(7):807-825]'},{id:"B50",body:'[APA. Dictionary of Psychology. New York: American Psychological Association;]'},{id:"B51",body:'[Hunsley J. Introduction to the special section on incremental validity and utility in clinical assessment. Psychological Assessment. 2003;15(4):443-445]'},{id:"B52",body:'[Guseh JS, Oritsejafor E. Democracy and economic growth in Africa: The cases of Ghana and South Africa. Journal of Third World Studies. 2005;22(2):121-137]'},{id:"B53",body:'[World Health Organization. International Statistical Classification of Diseases and Related Health Problems. Vol. 1. World Health Organization; 2004]'},{id:"B54",body:'[South Africa Government Medical Schemes Act 131 of 1998. https://www.gov.za/documents/medical-schemes-act]'},{id:"B55",body:'[American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. Washington DC: American Psychiatric Association; 1994]'},{id:"B56",body:'[World Health Organization, and Practice Management Information Corporation. ICD-9-CM: International Classification of Diseases, 9th Revision: Clinical Modification. Vol. 1. PMIC (Practice Management Information Corporation); 1998]'},{id:"B57",body:'[American Psychiatric Association. Diagnostic Criteria from DSM-IV-TR. Washington DC: American Psychiatric Association; 2000]'},{id:"B58",body:'[Luria AR. Higher cortical Functions in Man. London: Tavistock Publications; 1966. pp. 299-463]'},{id:"B59",body:'[Luria AR. The Working Brain. London: Penguin Books; 1973. pp. 343-346]'},{id:"B60",body:'[Department Health Republic of South Africa. 2004. South African ICD-10 Technical User Guide: Technical User Guide compiled by the Ministerial ICD-10 Task Team to Define Standards and Guidelines for ICD-10 Coding Implementation. Date: June 2014 of Version 2.00. Available from: http://www.health.gov.za]'},{id:"B61",body:'[Elliott J. Response to Rod Nicolson. In: Elliott J, Nicolson R, editors. Dyslexia: Developing the Debate. London: Bloomsbury; 2016. pp. 135-149]'},{id:"B62",body:'[Rossouw P, Kostyanaya M. Alexander Luria: Life, research and contribution to neuroscience. International Journal of Neuropsychotherapy. 2013;1(2):47-55]'},{id:"B63",body:'[Ministerial ICD-10 Task Team. 2014. South African ICD-10 Technical User Guide to Define Standards and Guidelines for ICD-10 Coding Implementation. June 2014 of Version 2.00. Available from: http://www.health.gov.za]'},{id:"B64",body:'[https://ldaamerica.org/types-of-learning-disabilities/]'},{id:"B65",body:'[Weindrich D, Jennen-Steinmetz C, Laucht M, Esser G, Schmidt MH. Epidemiology and prognosis of specific disorders of language and scholastic skills. European Child & Adolescent Psychiatry. 2000;9:186-194]'},{id:"B66",body:'[Potter CS. Using phonically based E-books to develop reading fluency. In: Gradinarova B, editor. E-Learning - Instructional Design, Organizational Strategy and Management. Rijeka: InTech; 2015. DOI: 10.5772/61607 Available from: http://www.intechopen.com/books/e-learning-instructional-design-organizational-strategy-and-management/using-phonically-based-e-books-to-develop-reading-fluency]'},{id:"B67",body:'[http://www.charlespotter.org]'},{id:"B68",body:'[Luria AR. The Working Brain: An Introduction to Neurospychology. Harmondsworth: Penguin Education; 1973]'},{id:"B69",body:'[Luria AR. Basic Problems of Neurolinguistics. Vol. 73. Berlin: Walter de Gruyter; 1976]'},{id:"B70",body:'[Potter CS. Training reading, writing and spelling fluency: Centre-periphery dissemination through interactive multimedia. In: Cvetković D, editor. Interactive Multimedia - Multimedia Production and Digital Storytelling. London: InIntech; 2019 Available from: https://www.intechopen.com/books/interactive-multimedia-multimedia-production-and-digital-storytelling/training-reading-writing-and-spelling-fluency-centre-periphery-dissemination-through-interactive-mul]'},{id:"B71",body:'[Potter CS. Activity-Based Online Learning: A Response to Dyslexia and COVID. London: IntechOpen; 2021. DOI: 10.5772/intechopen.96359 Available from: https://www.intechopen.com/online-first/75959]'},{id:"B72",body:'[Potter CS. 2012. The 3 x 3 Oral Impress System: A Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B73",body:'[Potter CS. 2014. The Seven Vowel Phonic Analysis System: A Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B74",body:'[Potter CS. 2018. Introducing the Seven Vowel Phonic Analysis System: A Manual for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B75",body:'[Potter CS. 2018. Foundation Level Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B76",body:'[Potter CS. 2018. Pre-reading Level Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B77",body:'[Potter CS. 2018. Manual for Administration of Core Tests. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B78",body:'[Potter CS. 2019. Introducing the 3 x 3 Oral Impress Method: A Manual for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B79",body:'[Potter CS. 2019. Introducing the Phonic Inventories: A Parent Implementer\'s Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B80",body:'[Potter CS. 2019. Using Phonological Referencing to Develop Phonic Associations: A Guide for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B81",body:'[Potter CS. 2020. Introducing the Targeted Analysis, Revisualisation and Sequential Spelling Programme: A Manual for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B82",body:'[Potter CS. 2020. Introducing the Foundation Level Activity Books Using the Structured Language Experience Approach: A Parent Implementer’s Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B83",body:'[Potter CS. 2020. Using the Targeted Analysis, Revisualisation and Sequential Spelling Programme: Method for Teaching Targeted Revisualisation in Implementing the Seven Vowel Phonic Analysis System. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B84",body:'[Potter CS. 2020. Using the Targeted Analysis, Revisualisation and Sequential Spelling Programme: Method for Developing Working Memory for Individual Words, Rhyming Word Families and Sequences of Words in Sentences. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B85",body:'[Potter CS. 2020. Using the Targeted Analysis, Revisualisation and Sequential Spelling Programme: Method for Increasing Span of Working Memory for Sequences of Words and Sequences of Sentences. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B86",body:'[Potter CS. 2021. Introducing the Pre-Reading and Foundation Level Materials: A Parent Implementer’s Manual. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B87",body:'[Rayner K, Sereno SC, Lesch MF, Pollatsek A. Phonological codes are automatically activated during reading: Evidence from an eye movement priming paradigm. Psychological Science. 1995;6:26-32]'},{id:"B88",body:'[Heckelman RG. In: Heckelman RG, editor. A Neurological Impress Method of Reading Instruction. Merced, CA: Merced County Schools Office; 1962]'},{id:"B89",body:'[Heckelman RG. A neurological-impress method of remedial-reading instruction. Academic Therapy. 1969;4(4):277-282]'},{id:"B90",body:'[Heckelman RG. N.I.M. revisited. Academic Therapy. 1986;21(4):411-420]'},{id:"B91",body:'[Jorm A, Share D. Phonological recoding and reading acquisition. Applied PsychoLinguistics. 1983;4:103-147]'},{id:"B92",body:'[Jorm A, Share D, Maclean R, Matthews R. Phonological recoding skills and learning to read: A longitudinal study. Applied PsychoLinguistics. 1984;5:201-207]'},{id:"B93",body:'[Share DL. Phonological recoding and self-teaching: Sine qua non of reading acquisition. Cognition. 1995;55(2):151-218]'},{id:"B94",body:'[Dehaene S. Reading in the Brain. New York: Penguin Books; 2009]'},{id:"B95",body:'[Dehaene S. How We Learn: Why Brains Learn Better than Any Machine... for now. New York: Penguin Books; 2020]'},{id:"B96",body:'[Bowers PG, Wolf M. Theoretical links between naming speed, precise timing mechanisms and orthographic skill in dyslexia. Reading and Writing: An Interdisciplinary Journal. 1993;5:69-85]'},{id:"B97",body:'[Wolf M, Bowers PG. The double-deficit hypothesis for the developmental dyslexias. Journal of Educational Psychology. 1999;91:415-438]'},{id:"B98",body:'[Cutting LE, Denckla MB. The relationship of serial rapid naming and word reading in normally developing readers: An exploratory model. Reading and Writing. 2001;14:673-705]'},{id:"B99",body:'[Wolf M, Bowers PG, Biddle K. Naming-speed processes, timing, and reading: A conceptual review. Journal of Learning Disabilities. 2000;33(4):387-407]'},{id:"B100",body:'[Norton ES, Wolf M. Rapid automatized Naming (RAN) and reading fluency: Implications for understanding and treatment of reading disabilities. Annual Review of Psychology. 2012;63(1):427-452]'},{id:"B101",body:'[Araújo S, Inácio F, Francisco A, Faísca L, Petersson KM, Reis A. Component processes subserving rapid automatized naming in dyslexic and non-dyslexic readers. Dyslexia. 2011;17:242-255]'},{id:"B102",body:'[Araújo S, Reis A, Petersson KM, Faísca L. Rapid automatized naming and reading performance: A meta-analysis. Journal of Educational Psychology. 2015;107(3):868-883]'},{id:"B103",body:'[Lemoine HE, Levy BA, Hutchinson A. Increasing the naming speed of poor readers: Representations formed across repetitions. Journal of Experimental Child Psychology. 1993;55(3):297-328]'},{id:"B104",body:'[De Jong PF, Vrielink LO. Rapid automatic naming: Easy to measure, hard to improve (quickly). Annals of Dyslexia. 2004;54:65-88]'},{id:"B105",body:'[Conrad NJ, Levy BA. Training letter and orthographic pattern recognition in children with slow naming speed. Reading and Writing. 2011;24:91-115]'},{id:"B106",body:'[Vander Stappen C, Van Reybroeck M. Phonological awareness and rapid automatized naming are independent phonological competencies with specific impacts on word reading and spelling: An intervention study. Frontiers in Psychology. 2018;9:320]'},{id:"B107",body:'[Potter CS. 2021. Using an Electronic Tachistoscope for Increasing Fluency in Reading, Writing and Spelling: A Guide for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B108",body:'[Share DL. Phonological recoding and orthographic learning: A direct test of the self-teaching hypothesis. Journal of Experimental Child Psychology. 1999;72(2):95-129]'},{id:"B109",body:'[Ehri LC. Reconceptualizing the development of sight word reading and its relationship to recoding. In: Gough PB, Ehri LE, Treiman R, editors. Reading Acquisition. Hillsdale, NJ: Erlbaum; 1992. pp. 105-143]'},{id:"B110",body:'[MacArthur CA, Graham S. Learning disabled students\' composing under three methods of text production: Handwriting, word processing, and dictation. Journal of Special Education. 1987;21:22-42]'},{id:"B111",body:'[McCutchen D. “Functional Automaticity” in Children\'s Writing: A Problem of Metacognitive Control. Written Communication. 1988;5(3):306-324]'},{id:"B112",body:'[McCutchen D. The magical number three, plus or minus two: Working memory in writing. In: Carlson JS, Butterfield EC, editors. Advances in Cognition and Educational Practice, VoL 2: Children\'s Writing: Toward a Process Theory of the Development of Skilled Writing. Greenwich, CI: JAI Press; 1994. pp. 1-30]'},{id:"B113",body:'[Swanson, H. L., Berninger, V. W. (1994). Working memory as a source of individual differences in children\'s writing. In J.S. Carlson, & E.C. Butterfield, Advances in Cognition and Educational Practice, VoL 2: Children\'s Writing: Toward a Process Theory of the Development of Skilled Writing. Greenwich, CI: JAI Press, pp. 31-56]'},{id:"B114",body:'[McCutchen D. A capacity theory of writing: Working memory in composition. Educational Psychology Review. 1996;8(3):299-325]'},{id:"B115",body:'[Newcomer PL, Barenbaum EM. The written composing ability of children with learning disabilities: A review of the literature from 1980 to 1990. J. Learn. Disab. 1991;24:578-593]'},{id:"B116",body:'[McCutchen D. Knowledge, processing, and working memory: Implications for a theory of writing. Educational Psychologist. 2000;35(1):13-23]'},{id:"B117",body:'[Seymour PHK, Aro M, Erskine JM. Foundation literacy acquisition in European orthographies. British Journal of Psychology. 2003;94:143-174]'},{id:"B118",body:'[Ziegler JC, Perry C, Ma-Wyatt A, Ladner D, Körne GS. Developmental dyslexia in different languages: Language specific or universal? Journal of Experimental Child Psychology. 2003;86:169-193]'},{id:"B119",body:'[Ziegler JC, Goswami U. Reading acquisition, developmental dyslexia, and skilled reading across languages: A psycholinguistic grain size theory. Psychological Bulletin. 2005;131(1):3-29]'},{id:"B120",body:'[Serrano F, Defior S. Dyslexia speed problems in a transparent orthography. Annals of Dyslexia. 2008;58:81]'},{id:"B121",body:'[Hengeveld K, Leufkens S. Transparent and non-transparent languages. Folia Linguistica. 2018;52(1):139-175]'},{id:"B122",body:'[Ellis NC, Hooper AM. Why learning to read is easier in Welsh than in English: Orthographic transparency effects evinced with frequency-matched tests. Applied PsychoLinguistics. 2001;22:571-599]'},{id:"B123",body:'[Spencer LH, Hanley JR. Effects of orthographic transparency on reading and phoneme awareness in children learning to read in Wales. British Journal of Psychology. 2003;94(1):1-28]'},{id:"B124",body:'[De Sousa D, Greenop K, Fry J. Cross-language transfer of spelling strategies in English and Afrikaans Grade 3 children. International Journal of Bilingual Education and Bilingualism. 2011;14(1):49-67]'},{id:"B125",body:'[Bruck M, Genesee F, Caravolas M. A cross-linguistic study of early literacy acquisition. In: Blachman BA, editor. Foundations of Reading Acquisition and Dyslexia: Implications for Early Intervention. Mahwah, NJ: Erlbaum; 1997. pp. 145-162]'},{id:"B126",body:'[Geva E, Wade-Woolley L, Shany M. The concurrent development of spelling and decoding in two different orthographies. Journal of Reading Behavior. 1993;25:383-406]'},{id:"B127",body:'[Sprenger-Charolles L, Siegel LS, Bonnet P. Reading and spelling acquisition in French: The role of phonological mediation and orthographic factors. Journal of Experimental Child Psychology. 1998;68:134-165]'},{id:"B128",body:'[Wimmer H, Goswami U. The influence of orthographic consistency on reading development: Word recognition in English and German children. Cognition. 1994;51:91-103]'},{id:"B129",body:'[Landerl K, Wimmer H, Frith U. The impact of orthographic consistency on dyslexia: A German–English comparison. Cognition. 1997;63:315-334]'},{id:"B130",body:'[Landerl K. Influences of orthographic consistency and reading instruction on the development of nonword reading skills. European Journal of Psychology of Education. 2000;15:239-257]'},{id:"B131",body:'[Potter CS. Multimethod research. In: Wagner C, Kawulich B, Garner M, editors. Doing Social Research: A Global Context. New York: McGrawhill; 2012. pp. 161-174]'},{id:"B132",body:'[De Jong PF, van der Leij A. Developmental changes in the manifestation of a phonological deficit in dyslexic children learning to read a regular orthography. Journal of Educational Psychology. 2003;95:22-40]'},{id:"B133",body:'[Hanley JR, Masterson J, Spencer LH, Evans D. How long do the advantages of learning a transparent orthography last? An investigation of the reading skills and incidence of dyslexia in Welsh children at 10 years of age. Quarterly Journal of Experimental Psychology: Human Experimental Psychology. 2004;57(A):1393-1410]'},{id:"B134",body:'[Moats LC. How spelling supports reading: And why it is more regular and predictable than you may think. American Educator. 2005;6(12–22):12-43]'},{id:"B135",body:'[Moats L. Knowledge foundations for teaching reading and spelling. Reading and Writing. 2009;22:379-399]'},{id:"B136",body:'[Potter CS. 2020. Introducing the Targeted Analysis, Revisualisation and Sequential Spelling Programme: A Manual for Parent Implementers. Electronic copy available from my practice by emailing me at pottercs@gmail.com]'},{id:"B137",body:'[Rudduck J, Hopkins D, editors. Research as a Basis for Teaching: Readings from the Work of Lawrence Stenhouse. London: Heinemann; 1985]'},{id:"B138",body:'[Stenhouse L. An Introduction to Curriculum Research and Development. London: Heinemann; 1975]'},{id:"B139",body:'[Stenhouse L. Curriculum Research and the Art of the Teacher. Curriculum. 1980;1((1), (Spring Issue)):40-44]'},{id:"B140",body:'[McIntosh K, Brown JA, Borgmeier CJ. Validity of functional behavior assessment within a response to intervention framework: Evidence, recommended practice, and future directions. Assessment for Effective Intervention. 2008;34(1):6-14]'},{id:"B141",body:'[Barnett D.W., Hawkins R., Prasse D., Graden J., Nantais M., Pan W. (2007). Decision-making validity in response to intervention. In: S.R. Jimerson, M.K. Burns & A.M. Van Der Heyden (Eds)., Handbook of Response to Intervention The Science and Practice of Assessment and Intervention. Boston, MA: Springer]'},{id:"B142",body:'[Spreen O. Learning disability, neurology, and long-term outcome: Some implications for the individual and for society. Journal of Clinical and Experimental Neuropsychology. 1989;11(3):389-408]'},{id:"B143",body:'[Doehring DG. Reading Disabilities: The Interaction of Reading, Language, and Neuro-Psychological Deficits. New York: Academic Press; 1981]'},{id:"B144",body:'[Denckla MB. Biological correlates of learning and attention: What is relevant to learning disability and attention-deficit hyperactivity disorder? Developmental and Behavioral Pediatrics. 1996;17:114-119]'},{id:"B145",body:'[Cherkes-Julkowski M. Learning disability, attention-deficit disorder, and language impairment as outcomes of prematurity: A longitudinal descriptive study. Journal of Learning Disabilities. 1998;31(3):294-306]'},{id:"B146",body:'[Guba EG, Lincoln YS. Epistemological and methodological bases of naturalistic inquiry. Educational Communication & Technology Journal. 1982;30(4):233-252]'},{id:"B147",body:'[Guba EG, Lincoln YS. Naturalistic Inquiry. Beverly Hills, CA: Sage Publications; 1985. p. 1985]'},{id:"B148",body:'[Dawes RM. Two methods for studying the incremental validity of a Rorschach variable. Psychological Assessment. 1999;11:297-302]'}],footnotes:[{id:"fn1",explanation:"Dr. Charles Potter’s Reading Programme is an intervention programme linked to the author’s practice as a psychologist. The programme uses electronic materials as the basis for intervention, and has assembled an extensive database of reading fluency books as well as developmental writing and spelling materials which are implemented using methods developed as part of my clinical work as a psychologist. Training is offered to prospective users of the materials and methods, and as a result there is now a network of parent, teacher and therapist users in different countries who connect with each other by cell phone and email."},{id:"fn2",explanation:"The ICD-10 (International Statistical Classification of Diseases and Related Health Problems – Tenth Revision) is a diagnostic coding standard owned and maintained by the World Health Organisation (WHO) [53]. The coding standard has been adopted by the National Health Information System of South Africa (NHISSA), and forms part of the health information strategy of the South African National Department of Health (NDoH). The standard serves as the diagnostic coding standard of choice in both the public and private healthcare sectors in South Africa for morbidity coding under Regulation 5(f) of the Medical Schemes Act 131 of 1998 [54]."},{id:"fn3",explanation:"The ICD is produced by a global health agency (The World Health Organisation) with a constitutional public health mission, while the DSM is produced by a national professional association (The American Psychiatric Association). While initially using different diagnostic classification systems, the DSM and ICD have over time become very similar, due to collaboration between the two organisations, with the result that the coding system utilised by the DSM-IV [55] is designed to correspond with codes from the International Classification of Diseases, Ninth Revision, Clinical Modification, commonly referred to as the ICD-9-CM [56]. The coding system for the later revised DSM-IV TR [57] is designed to correspond with codes from the International Classification of Diseases, Tenth Revision, commonly referred to as ICD-10 [53], which has been adopted by South African medical aid societies."},{id:"fn4",explanation:"In South Africa, due to the similarity between the DSM IV and ICD classification systems, the DSM IV criteria have been used since August 2005 for the purpose of deriving ICD-10 codes by all healthcare providers except pharmacists, clinical support and allied healthcare providers [60]. The mandatory submission of ICD-10 codes by these groups was postponed until 1 January 2006. As from this date. The criteria have been referred to as the ICD DSMIV criteria, and ICD-10 coding has been mandatory for all health providers (including pharmacists and clinical support and allied healthcare providers). At time of writing the ICD DSMIV criteria have been phased out by South African medical aids and replaced by the ICD DSM V criteria."},{id:"fn5",explanation:"The author has worked with children under the care of a number of paediatricians and neurologists, but particularly closely with Dr. Graeme Maxwell, neurosurgeon, of Sandton Clinic until his retirement in 2020, and more recently with Dr. Dimitri Manoussakis, neurologist, of Flora Clinic. The stabilisation of focus and attentional difficulties as well as attendant attentional lapses and symptoms of cortical irritability has been an essential feature of the fluency-based interventions provided in the author’s practice. Behavioural, emotional, parental as well as chemical interventions are also likely to contribute to the gains made by children treated by the programmes described in this chapter."},{id:"fn6",explanation:"In South Africa, due to the similarity between the DSM IV and ICD classification systems, the DSM IV criteria have been used since August 2005 for the purpose of deriving ICD-10 codes by all healthcare providers except pharmacists, clinical support and allied healthcare providers. The DSM V criteria were published in May 2013, with both ICD-9-CM and ICD-10-CM codes assigned to each of the DSM V diagnoses [63]."},{id:"fn7",explanation:"The author has applied the response to intervention classification model working in association with Robert Thomas-Stark, psychologist, of the Centre for Therapeutic Excellence, Johannesburg. To maximise validity, this has involved longitudinal and cross-sectional assessment by two therapists, leading to a collaborative diagnostic report."}],contributors:[{corresp:"yes",contributorFullName:"Charles Potter",address:"pottercs@gmail.com",affiliation:'- Educational Psychologist in Private Practice, Johannesburg, South Africa
'}],corrections:null},book:{id:"10910",type:"book",title:"Learning Disabilities",subtitle:"Neurobiology, Assessment, Clinical Features and Treatments",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",publishedDate:"March 30th 2022",bookSignature:"Sandro Misciagna",coverURL:"https://cdn.intechopen.com/books/images_new/10910.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-588-0",printIsbn:"978-1-83968-587-3",pdfIsbn:"978-1-83968-589-7",isAvailableForWebshopOrdering:!0,editors:[{id:"103586",title:null,name:"Sandro",middleName:null,surname:"Misciagna",slug:"sandro-misciagna",fullName:"Sandro Misciagna"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"100751",title:"Dr.",name:"Lucia",middleName:null,surname:"Leccisotti",email:"leccilu@gmail.com",fullName:"Lucia Leccisotti",slug:"lucia-leccisotti",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Catholic University of the Sacred Heart",institutionURL:null,country:{name:"Italy"}}},booksEdited:[],chaptersAuthored:[{id:"20939",title:"Cardiac Rhythm Management Device Infections: Imaging Examinations to Direct Replacement Timing",slug:"cardiac-rhythm-management-device-infections-imaging-examinations-to-direct-replacement-timing",abstract:null,signatures:"Michela Casella, Francesco Perna, Antonio Dello Russo, Gemma Pelargonio, Stefano Bartoletti, Lucia Leccisotti, Ghaliah Al-Mohani, Pasquale Santangeli, Luigi Di Biase, Andrea Natale, Fulvio Bellocci and Claudio Tondo",authors:[{id:"56763",title:"Dr.",name:"Michela",surname:"Casella",fullName:"Michela Casella",slug:"michela-casella",email:"michelacasella@hotmail.com"},{id:"56766",title:"Dr.",name:"Antonio",surname:"Dello Russo",fullName:"Antonio Dello Russo",slug:"antonio-dello-russo",email:"antonio.dellorusso@gmail.com"},{id:"56767",title:"Dr.",name:"Claudio",surname:"Tondo",fullName:"Claudio Tondo",slug:"claudio-tondo",email:"claudio.tondo@gmail.com"},{id:"56768",title:"Dr.",name:"Francesco",surname:"Perna",fullName:"Francesco Perna",slug:"francesco-perna",email:"franceperna@gmail.com"},{id:"100749",title:"Dr.",name:"Gemma",surname:"Pelargonio",fullName:"Gemma Pelargonio",slug:"gemma-pelargonio",email:"pelargo.g@gmail.com"},{id:"100750",title:"Dr.",name:"Stefano",surname:"Bartoletti",fullName:"Stefano Bartoletti",slug:"stefano-bartoletti",email:"bartolets@gmail.com"},{id:"100751",title:"Dr.",name:"Lucia",surname:"Leccisotti",fullName:"Lucia Leccisotti",slug:"lucia-leccisotti",email:"leccilu@gmail.com"},{id:"100754",title:"Dr.",name:"Ghaliah",surname:"Al-Mohani",fullName:"Ghaliah Al-Mohani",slug:"ghaliah-al-mohani",email:"ghani@gmail.com"},{id:"100756",title:"Dr.",name:"Pasquale",surname:"Santangeli",fullName:"Pasquale Santangeli",slug:"pasquale-santangeli",email:"nino@gmail.com"},{id:"100761",title:"Dr.",name:"Luigi",surname:"Di Biase",fullName:"Luigi Di Biase",slug:"luigi-di-biase",email:"dibbiase@gmail.com"},{id:"100762",title:"Prof.",name:"Andrea",surname:"Natale",fullName:"Andrea Natale",slug:"andrea-natale",email:"inatale@gmail.com"},{id:"100766",title:"Prof.",name:"Fulvio",surname:"Bellocci",fullName:"Fulvio Bellocci",slug:"fulvio-bellocci",email:"belloc@gmail.com"}],book:{id:"284",title:"CT Scanning",slug:"ct-scanning-techniques-and-applications",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"37252",title:"Prof.",name:"Qian",surname:"Dong",slug:"qian-dong",fullName:"Qian Dong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"40051",title:"Prof.",name:"Andy (Yuanguang)",surname:"Xu",slug:"andy-(yuanguang)-xu",fullName:"Andy (Yuanguang) Xu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"49101",title:"Dr.",name:"Ieneke",surname:"Hartmann",slug:"ieneke-hartmann",fullName:"Ieneke Hartmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"52590",title:"Prof.",name:"Jingjing",surname:"Chen",slug:"jingjing-chen",fullName:"Jingjing Chen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"53392",title:"BSc",name:"Joshua",surname:"Schaefferkoetter",slug:"joshua-schaefferkoetter",fullName:"Joshua Schaefferkoetter",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"53451",title:"Dr.",name:"Amy",surname:"LeBlanc",slug:"amy-leblanc",fullName:"Amy LeBlanc",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"53452",title:"Prof.",name:"Eric",surname:"Carlson",slug:"eric-carlson",fullName:"Eric Carlson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"114852",title:"Dr.",name:"Pauline",surname:"Abrahams-van Doorn",slug:"pauline-abrahams-van-doorn",fullName:"Pauline Abrahams-van Doorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"135878",title:"Dr.",name:"Cheng-Shi",surname:"Wuu",slug:"cheng-shi-wuu",fullName:"Cheng-Shi Wuu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Columbia University",institutionURL:null,country:{name:"United States of America"}}},{id:"135879",title:"Dr.",name:"C",surname:"Schaefer-Prokop",slug:"c-schaefer-prokop",fullName:"C Schaefer-Prokop",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University Medical Center Utrecht",institutionURL:null,country:{name:"Netherlands"}}}]},generic:{page:{slug:"open-access-funding-funders-list",title:"List of Funders by Country",intro:"If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\nIMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
",metaTitle:"List of Funders by Country",metaDescription:"If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).",metaKeywords:null,canonicalURL:"/page/open-access-funding-funders-list",contentRaw:'[{"type":"htmlEditorComponent","content":"AUSTRALIA
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nAUSTRIA
\\n\\nMonographs Only
\\n\\n\\n\\nCANADA
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nCHINA, PEOPLE'S REPUBLIC OF
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nEUROPE
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nFINLAND
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nGERMANY
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nHUNGARY
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nINTERNATIONAL (OTHER)
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nIRELAND
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nMonographs Only
\\n\\n\\n\\nLITHUANIA
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nPORTUGAL
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nSLOVENIA
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nSWITZERLAND
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nTHE NETHERLANDS
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nUNITED KINGDOM
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\t- Department for International Development (See also the Implementation Guide)
\\n\\t- UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
\\n\\t- The Leverhulme Trust (See also the FAQs)
\\n\\t- Wellcome Library
\\n\\t- Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
\\n
\\n"}]'},components:[{type:"htmlEditorComponent",content:'AUSTRALIA
\n\nBook Chapters and Monographs
\n\n\n\nAUSTRIA
\n\nMonographs Only
\n\n\n\nCANADA
\n\nBook Chapters and Monographs
\n\n\n\nCHINA, PEOPLE'S REPUBLIC OF
\n\nBook Chapters and Monographs
\n\n\n\nEUROPE
\n\nBook Chapters and Monographs
\n\n\n\nFINLAND
\n\nBook Chapters and Monographs
\n\n\n\nGERMANY
\n\nBook Chapters and Monographs
\n\n\n\nHUNGARY
\n\nBook Chapters and Monographs
\n\n\n\nINTERNATIONAL (OTHER)
\n\nBook Chapters and Monographs
\n\n\n\nIRELAND
\n\nBook Chapters and Monographs
\n\n\n\nMonographs Only
\n\n\n\nLITHUANIA
\n\nBook Chapters and Monographs
\n\n\n\nPORTUGAL
\n\nBook Chapters and Monographs
\n\n\n\nSLOVENIA
\n\nBook Chapters and Monographs
\n\n\n\nSWITZERLAND
\n\nBook Chapters and Monographs
\n\n\n\nTHE NETHERLANDS
\n\nBook Chapters and Monographs
\n\n\n\nUNITED KINGDOM
\n\nBook Chapters and Monographs
\n\n\n\t- Department for International Development (See also the Implementation Guide)
\n\t- UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
\n\t- The Leverhulme Trust (See also the FAQs)
\n\t- Wellcome Library
\n\t- Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
\n
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"5,6,12,13,18"},books:[{type:"book",id:"11648",title:"Current Status and Ecological Aspects of Seabirds",subtitle:null,isOpenForSubmission:!0,hash:"7754b354f7deebdb8576189aefbdbc5c",slug:null,bookSignature:"Dr. Muhammad Nawaz Rajpar",coverURL:"https://cdn.intechopen.com/books/images_new/11648.jpg",editedByType:null,editors:[{id:"183095",title:"Dr.",name:"Muhammad Nawaz",surname:"Rajpar",slug:"muhammad-nawaz-rajpar",fullName:"Muhammad Nawaz Rajpar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11620",title:"Tomato - From Cultivation to Processing Technology",subtitle:null,isOpenForSubmission:!0,hash:"cdc23b5aad5d52bc0f0327c453ac7a1b",slug:null,bookSignature:"Prof. Pranas Viskelis, Dr. Dalia Urbonavičienė and Dr. Jonas Viskelis",coverURL:"https://cdn.intechopen.com/books/images_new/11620.jpg",editedByType:null,editors:[{id:"83785",title:"Prof.",name:"Pranas",surname:"Viskelis",slug:"pranas-viskelis",fullName:"Pranas Viskelis"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11020",title:"Dietary Supplements - Challenges and Future Research",subtitle:null,isOpenForSubmission:!0,hash:"2283ae2d0816c17ad46cbedbe4ce5e78",slug:null,bookSignature:"Dr. Venketeshwer Rao and Dr. Leticia Rao",coverURL:"https://cdn.intechopen.com/books/images_new/11020.jpg",editedByType:null,editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11627",title:"Oilseed Crops - Biology, Production and Processing",subtitle:null,isOpenForSubmission:!0,hash:"010cdbbb6a716d433e632b350d4dcafe",slug:null,bookSignature:"Prof. Mirza Hasanuzzaman and MSc. Kamrun Nahar",coverURL:"https://cdn.intechopen.com/books/images_new/11627.jpg",editedByType:null,editors:[{id:"76477",title:"Prof.",name:"Mirza",surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11615",title:"Humus and Humic Substances - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"a9b75be6b30278fca930c4dd560a8b2b",slug:null,bookSignature:"Prof. Abdelhadi Makan",coverURL:"https://cdn.intechopen.com/books/images_new/11615.jpg",editedByType:null,editors:[{id:"247727",title:"Prof.",name:"Abdelhadi",surname:"Makan",slug:"abdelhadi-makan",fullName:"Abdelhadi Makan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11802",title:"Honey - Composition and Properties",subtitle:null,isOpenForSubmission:!0,hash:"60482dae5e08f5b22b0c7a2749cdfc02",slug:null,bookSignature:"Dr. Muhammad Imran, Dr. Muhammad Haseeb Ahmad and Dr. Rabia Shabir Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/11802.jpg",editedByType:null,editors:[{id:"208646",title:"Dr.",name:"Muhammad",surname:"Imran",slug:"muhammad-imran",fullName:"Muhammad Imran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10744",title:"Astrocytes in Brain Communication and Disease",subtitle:null,isOpenForSubmission:!0,hash:"8b6a8e2bb5f070305768945fdef8eed2",slug:null,bookSignature:"Prof. Denis Larrivee",coverURL:"https://cdn.intechopen.com/books/images_new/10744.jpg",editedByType:null,editors:[{id:"206412",title:"Prof.",name:"Denis",surname:"Larrivee",slug:"denis-larrivee",fullName:"Denis Larrivee"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11667",title:"Marine Pollution - Recent Developments",subtitle:null,isOpenForSubmission:!0,hash:"e524cd97843b075a724e151256773631",slug:null,bookSignature:"Dr. Monique Mancuso",coverURL:"https://cdn.intechopen.com/books/images_new/11667.jpg",editedByType:null,editors:[{id:"318562",title:"Dr.",name:"Monique",surname:"Mancuso",slug:"monique-mancuso",fullName:"Monique Mancuso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11638",title:"Meat Science and Nutrition - Recent Advances and Innovative Processing Technologies",subtitle:null,isOpenForSubmission:!0,hash:"3923d89fcf837fac59c906f9694ab1f8",slug:null,bookSignature:"Dr. Muhammad Sajid Arshad",coverURL:"https://cdn.intechopen.com/books/images_new/11638.jpg",editedByType:null,editors:[{id:"192998",title:"Dr.",name:"Muhammad Sajid",surname:"Arshad",slug:"muhammad-sajid-arshad",fullName:"Muhammad Sajid Arshad"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11619",title:"Root Vegetables",subtitle:null,isOpenForSubmission:!0,hash:"2c5535e66fed5abd8f80ee521b51b2d3",slug:null,bookSignature:"Dr. Prashant Kaushik",coverURL:"https://cdn.intechopen.com/books/images_new/11619.jpg",editedByType:null,editors:[{id:"311935",title:"Dr.",name:"Prashant",surname:"Kaushik",slug:"prashant-kaushik",fullName:"Prashant Kaushik"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11644",title:"Structural and Molecular Aspects of DNA Repair",subtitle:null,isOpenForSubmission:!0,hash:"83dfefc2400d2d037281f1e25bbc544b",slug:null,bookSignature:"Prof. Subrata Kumar Dey",coverURL:"https://cdn.intechopen.com/books/images_new/11644.jpg",editedByType:null,editors:[{id:"31178",title:"Prof.",name:"Subrata",surname:"Dey",slug:"subrata-dey",fullName:"Subrata Dey"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11622",title:"Recent Advances in Grapes and Wine Production - New Perspectives to Improve the Quality",subtitle:null,isOpenForSubmission:!0,hash:"79cdf0cd1a7106746cca196c1292ed36",slug:null,bookSignature:"Prof. António M. Jordão, Prof. Renato Vasconcelos Botelho and Dr. Uros Miljic",coverURL:"https://cdn.intechopen.com/books/images_new/11622.jpg",editedByType:null,editors:[{id:"186821",title:"Prof.",name:"António",surname:"M. Jordão",slug:"antonio-m.-jordao",fullName:"António M. Jordão"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:43},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:24},{group:"topic",caption:"Computer and Information Science",value:9,count:19},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:61},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:124},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:3},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:77},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4380},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3385,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1875,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3842,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3008,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1109,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1010,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3918,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",publishedDate:"May 11th 2022",numberOfDownloads:1654,editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7686,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3444,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"115",title:"Control Engineering",slug:"engineering-control-engineering",parent:{id:"11",title:"Engineering",slug:"engineering"},numberOfBooks:51,numberOfSeries:0,numberOfAuthorsAndEditors:1216,numberOfWosCitations:1462,numberOfCrossrefCitations:1050,numberOfDimensionsCitations:1834,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"115",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10972",title:"Control Systems in Engineering and Optimization Techniques",subtitle:null,isOpenForSubmission:!1,hash:"f92f65447d0f90b67465865d41a61cd1",slug:"control-systems-in-engineering-and-optimization-techniques",bookSignature:"P. Balasubramaniam, Sathiyaraj Thambiayya, Kuru Ratnavelu and JinRong Wang",coverURL:"https://cdn.intechopen.com/books/images_new/10972.jpg",editedByType:"Edited by",editors:[{id:"252215",title:"Dr.",name:"P.",middleName:null,surname:"Balasubramaniam",slug:"p.-balasubramaniam",fullName:"P. Balasubramaniam"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9976",title:"Fuzzy Systems",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"5c4c0d41cf25d2e8fda944450ac46d95",slug:"fuzzy-systems-theory-and-applications",bookSignature:"Constantin Volosencu",coverURL:"https://cdn.intechopen.com/books/images_new/9976.jpg",editedByType:"Edited by",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9887",title:"Control Based on PID Framework",subtitle:"The Mutual Promotion of Control and Identification for Complex Systems",isOpenForSubmission:!1,hash:"d2dae75adf13d3e082893264d82967fb",slug:"control-based-on-pid-framework-the-mutual-promotion-of-control-and-identification-for-complex-systems",bookSignature:"Wei Wang",coverURL:"https://cdn.intechopen.com/books/images_new/9887.jpg",editedByType:"Edited by",editors:[{id:"101176",title:"Prof.",name:"Wei",middleName:null,surname:"Wang",slug:"wei-wang",fullName:"Wei Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9893",title:"Automation and Control",subtitle:null,isOpenForSubmission:!1,hash:"09ba24f6ac88af7f0aaff3029714ae48",slug:"automation-and-control",bookSignature:"Constantin Voloşencu, Serdar Küçük, José Guerrero and Oscar Valero",coverURL:"https://cdn.intechopen.com/books/images_new/9893.jpg",editedByType:"Edited by",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9287",title:"Control Theory in Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7c584de5f40193b636833aa812dab9d5",slug:"control-theory-in-engineering",bookSignature:"Constantin Volosencu, Ali Saghafinia, Xian Du and Sohom Chakrabarty",coverURL:"https://cdn.intechopen.com/books/images_new/9287.jpg",editedByType:"Edited by",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8347",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",subtitle:null,isOpenForSubmission:!1,hash:"3d7024a8d7d8afed093c9c79ec31f15a",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",bookSignature:"Lulu Wang and Liandong Yu",coverURL:"https://cdn.intechopen.com/books/images_new/8347.jpg",editedByType:"Edited by",editors:[{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7485",title:"Applied Modern Control",subtitle:null,isOpenForSubmission:!1,hash:"c7a7be73f7232e08867ed81bdf9850c6",slug:"applied-modern-control",bookSignature:"Le Anh Tuan",coverURL:"https://cdn.intechopen.com/books/images_new/7485.jpg",editedByType:"Edited by",editors:[{id:"180550",title:"Dr.",name:"Le",middleName:null,surname:"Anh Tuan",slug:"le-anh-tuan",fullName:"Le Anh Tuan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6806",title:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications",subtitle:null,isOpenForSubmission:!1,hash:"fedf4479b910cbcee3025e391f073417",slug:"fuzzy-logic-based-in-optimization-methods-and-control-systems-and-its-applications",bookSignature:"Ali Sadollah",coverURL:"https://cdn.intechopen.com/books/images_new/6806.jpg",editedByType:"Edited by",editors:[{id:"147215",title:"Dr.",name:"Ali",middleName:null,surname:"Sadollah",slug:"ali-sadollah",fullName:"Ali Sadollah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6323",title:"PID Control for Industrial Processes",subtitle:null,isOpenForSubmission:!1,hash:"3994459e0812cf44a04b3f6c3e28e9c1",slug:"pid-control-for-industrial-processes",bookSignature:"Mohammad Shamsuzzoha",coverURL:"https://cdn.intechopen.com/books/images_new/6323.jpg",editedByType:"Edited by",editors:[{id:"87344",title:"Dr.",name:"Mohammad",middleName:null,surname:"Shamsuzzoha",slug:"mohammad-shamsuzzoha",fullName:"Mohammad Shamsuzzoha"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6101",title:"Advances in Some Hypersonic Vehicles Technologies",subtitle:null,isOpenForSubmission:!1,hash:"5ecc3136420d6f6cc0de2da29f9d749c",slug:"advances-in-some-hypersonic-vehicles-technologies",bookSignature:"Ramesh K. Agarwal",coverURL:"https://cdn.intechopen.com/books/images_new/6101.jpg",editedByType:"Edited by",editors:[{id:"38519",title:"Prof.",name:"Ramesh K.",middleName:null,surname:"Agarwal",slug:"ramesh-k.-agarwal",fullName:"Ramesh K. Agarwal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6240",title:"Adaptive Robust Control Systems",subtitle:null,isOpenForSubmission:!1,hash:"19601f78e28ac1956912e5eeb6b834ac",slug:"adaptive-robust-control-systems",bookSignature:"Le Anh Tuan",coverURL:"https://cdn.intechopen.com/books/images_new/6240.jpg",editedByType:"Edited by",editors:[{id:"180551",title:"Prof.",name:"Anh Tuan",middleName:null,surname:"Le",slug:"anh-tuan-le",fullName:"Anh Tuan Le"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5823",title:"Recent Developments in Sliding Mode Control",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"1075a2f87196085bae2babfac6bc3d52",slug:"recent-developments-in-sliding-mode-control-theory-and-applications",bookSignature:"Andrzej Bartoszewicz",coverURL:"https://cdn.intechopen.com/books/images_new/5823.jpg",editedByType:"Edited by",editors:[{id:"18337",title:"Prof.",name:"Andrzej",middleName:null,surname:"Bartoszewicz",slug:"andrzej-bartoszewicz",fullName:"Andrzej Bartoszewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:51,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"34221",doi:"10.5772/36321",title:"A Mamdani Type Fuzzy Logic Controller",slug:"a-mamdani-type-fuzzy-logic-controller",totalDownloads:12524,totalCrossrefCites:40,totalDimensionsCites:67,abstract:null,book:{id:"2273",slug:"fuzzy-logic-controls-concepts-theories-and-applications",title:"Fuzzy Logic",fullTitle:"Fuzzy Logic - Controls, Concepts, Theories and Applications"},signatures:"Ion Iancu",authors:[{id:"107854",title:"Prof.",name:"Ion",middleName:null,surname:"Iancu",slug:"ion-iancu",fullName:"Ion Iancu"}]},{id:"29691",doi:"10.5772/37638",title:"A Real-Time Gradient Method for Nonlinear Model Predictive Control",slug:"a-real-time-gradient-method-for-nonlinear-model-predictive-control",totalDownloads:2656,totalCrossrefCites:52,totalDimensionsCites:66,abstract:null,book:{id:"2091",slug:"frontiers-of-model-predictive-control",title:"Frontiers of Model Predictive Control",fullTitle:"Frontiers of Model Predictive Control"},signatures:"Knut Graichen and Bartosz Käpernick",authors:[{id:"113632",title:"Prof.",name:"Knut",middleName:null,surname:"Graichen",slug:"knut-graichen",fullName:"Knut Graichen"},{id:"139321",title:"MSc.",name:"Bartosz",middleName:null,surname:"Kaepernick",slug:"bartosz-kaepernick",fullName:"Bartosz Kaepernick"}]},{id:"62600",doi:"10.5772/intechopen.79552",title:"Introductory Chapter: Which Membership Function is Appropriate in Fuzzy System?",slug:"introductory-chapter-which-membership-function-is-appropriate-in-fuzzy-system-",totalDownloads:1904,totalCrossrefCites:31,totalDimensionsCites:53,abstract:null,book:{id:"6806",slug:"fuzzy-logic-based-in-optimization-methods-and-control-systems-and-its-applications",title:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications",fullTitle:"Fuzzy Logic Based in Optimization Methods and Control Systems and Its Applications"},signatures:"Ali Sadollah",authors:[{id:"147215",title:"Dr.",name:"Ali",middleName:null,surname:"Sadollah",slug:"ali-sadollah",fullName:"Ali Sadollah"}]},{id:"4579",doi:"10.5772/5812",title:"Cumulative Vehicle Routing Problems",slug:"cumulative_vehicle_routing_problems",totalDownloads:3388,totalCrossrefCites:24,totalDimensionsCites:45,abstract:null,book:{id:"5332",slug:"vehicle_routing_problem",title:"Vehicle Routing Problem",fullTitle:"Vehicle Routing Problem"},signatures:"İmdat Kara, Bahar Yetiş Kara and M. Kadri Yetiş",authors:null},{id:"15216",doi:"10.5772/14532",title:"Super-Twisting Sliding Mode in Motion Control Systems",slug:"super-twisting-sliding-mode-in-motion-control-systems",totalDownloads:5820,totalCrossrefCites:19,totalDimensionsCites:39,abstract:null,book:{id:"103",slug:"sliding-mode-control",title:"Sliding Mode Control",fullTitle:"Sliding Mode Control"},signatures:"Jorge Rivera, Luis Garcia, Christian Mora, 0Juan J. Raygoza and Susana Ortega",authors:[{id:"18069",title:"Dr.",name:"Jorge",middleName:null,surname:"Rivera",slug:"jorge-rivera",fullName:"Jorge Rivera"},{id:"22689",title:"Prof.",name:"Luis",middleName:null,surname:"Garcia",slug:"luis-garcia",fullName:"Luis Garcia"},{id:"22690",title:"Prof.",name:"Christian",middleName:null,surname:"Mora",slug:"christian-mora",fullName:"Christian Mora"},{id:"23671",title:"Dr.",name:"Juan José",middleName:null,surname:"Raygoza",slug:"juan-jose-raygoza",fullName:"Juan José Raygoza"},{id:"23672",title:"Dr.",name:"Susana",middleName:null,surname:"Ortega",slug:"susana-ortega",fullName:"Susana Ortega"}]}],mostDownloadedChaptersLast30Days:[{id:"53024",title:"Key Aspects for Implementing ISO/IEC 17025 Quality Management Systems at Materials Science Laboratories",slug:"key-aspects-for-implementing-iso-iec-17025-quality-management-systems-at-materials-science-laborator",totalDownloads:2798,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Implementing a quality management system based on the requirements specified in ISO/IEC 17025 standard at materials science laboratories is challenging, mainly due to two main factors: (i) the high technical complexity degree of some tests used for materials characterization and (ii) the fact that most materials science laboratories provide materials characterization tests and also carry out research and development activities. In this context, this chapter presents key subjects while implementing a quality management system at materials science laboratories and some considerations on strategies for effectively implementing such systems.",book:{id:"5486",slug:"quality-control-and-assurance-an-ancient-greek-term-re-mastered",title:"Quality Control and Assurance",fullTitle:"Quality Control and Assurance - An Ancient Greek Term Re-Mastered"},signatures:"Rodrigo S. Neves, Daniel P. Da Silva, Carlos E. C. Galhardo, Erlon H.\nM. Ferreira, Rafael M. Trommer and Jailton C. Damasceno",authors:[{id:"20571",title:"Prof.",name:"Erlon H.",middleName:null,surname:"Martins Ferreira",slug:"erlon-h.-martins-ferreira",fullName:"Erlon H. Martins Ferreira"},{id:"145815",title:"Dr.",name:"Rodrigo",middleName:null,surname:"De Santis Neves",slug:"rodrigo-de-santis-neves",fullName:"Rodrigo De Santis Neves"},{id:"145816",title:"Dr.",name:"Carlos",middleName:null,surname:"Eduardo Cardoso Galhardo",slug:"carlos-eduardo-cardoso-galhardo",fullName:"Carlos Eduardo Cardoso Galhardo"},{id:"159056",title:"Dr.",name:"Jailton",middleName:null,surname:"Damasceno",slug:"jailton-damasceno",fullName:"Jailton Damasceno"},{id:"191863",title:"Dr.",name:"Daniel",middleName:"Pereira Da Silva",surname:"Fernandes",slug:"daniel-fernandes",fullName:"Daniel Fernandes"},{id:"191865",title:"Dr.",name:"Rafael",middleName:null,surname:"Mello Trommer",slug:"rafael-mello-trommer",fullName:"Rafael Mello Trommer"}]},{id:"53946",title:"The Evolution of Quality Concepts and the Related Quality Management",slug:"the-evolution-of-quality-concepts-and-the-related-quality-management",totalDownloads:4400,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"Enterprises usually adopt some quality practices to control the product quality during the manufacturing process in order to assure the delivery of qualitative good products to customers. The quality practices or quality management systems adopted by industries will further evolve due to the changes of quality concepts as time goes by. This chapter discusses the change of quality concepts and the related revolution of quality management systems in the past century. The quality concepts were gradually changed from the achievement of quality standards, satisfaction of customer needs, and expectations to customer delight. Since merely satisfying customers is not enough to ensure customer loyalty, the enterprises gradually focus on customers’ emotional responses and their delight in order to pursue their loyalty. The emotion of “delight” is composed of “joy” and “surprise,” which can be achieved as the customers’ latent requirements are satisfied. Thus, the concept of “customer delight” and the means to provide the innovative quality so as to meet the unsatisfied customers’ latent needs are elaborated on. Finally, a framework of innovation creation is developed that is based on the mining of customer's latent requirements. This outline will manifest the essential elements of the related operation steps.",book:{id:"5486",slug:"quality-control-and-assurance-an-ancient-greek-term-re-mastered",title:"Quality Control and Assurance",fullTitle:"Quality Control and Assurance - An Ancient Greek Term Re-Mastered"},signatures:"Ching-Chow Yang",authors:[{id:"11862",title:"Prof.",name:"Ching-Chow",middleName:null,surname:"Yang",slug:"ching-chow-yang",fullName:"Ching-Chow Yang"}]},{id:"62915",title:"Advanced Methods of PID Controller Tuning for Specified Performance",slug:"advanced-methods-of-pid-controller-tuning-for-specified-performance",totalDownloads:3439,totalCrossrefCites:10,totalDimensionsCites:16,abstract:"This chapter provides a concise survey, classification and historical perspective of practice-oriented methods for designing proportional-integral-derivative (PID) controllers and autotuners showing the persistent demand for PID tuning algorithms that integrate performance requirements into the tuning algorithm. The proposed frequency-domain PID controller design method guarantees closed-loop performance in terms of commonly used time-domain specifications. One of its major benefits is universal applicability for both slow and fast-controlled plants with unknown mathematical model. Special charts called B-parabolas were developed as a practical design tool that enables consistent and systematic shaping of the closed-loop step response with regard to specified performance and dynamics of the uncertain controlled plant.",book:{id:"6323",slug:"pid-control-for-industrial-processes",title:"PID Control for Industrial Processes",fullTitle:"PID Control for Industrial Processes"},signatures:"Štefan Bucz and Alena Kozáková",authors:[{id:"21933",title:"Ms.",name:"Alena",middleName:null,surname:"Kozakova",slug:"alena-kozakova",fullName:"Alena Kozakova"},{id:"213658",title:"Dr.",name:"Štefan",middleName:null,surname:"Bucz",slug:"stefan-bucz",fullName:"Štefan Bucz"}]},{id:"75699",title:"Data Clustering for Fuzzyfier Value Derivation",slug:"data-clustering-for-fuzzyfier-value-derivation",totalDownloads:279,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The fuzzifier value m is improving significant factor for achieving the accuracy of data. Therefore, in this chapter, various clustering method is introduced with the definition of important values for clustering. To adaptively calculate the appropriate purge value of the gap type −2 fuzzy c-means, two fuzzy values m1 and m2 are provided by extracting information from individual data points using a histogram scheme. Most of the clustering in this chapter automatically obtains determination of m1 and m2 values that depended on existent repeated experiments. Also, in order to increase efficiency on deriving valid fuzzifier value, we introduce the Interval type-2 possibilistic fuzzy C-means (IT2PFCM), as one of advanced fuzzy clustering method to classify a fixed pattern. In Efficient IT2PFCM method, proper fuzzifier values for each data is obtained from an algorithm including histogram analysis and Gaussian Curve Fitting method. Using the extracted information form fuzzifier values, two modified fuzzifier value m1 and m2 are determined. These updated fuzzifier values are used to calculated the new membership values. Determining these updated values improve not only the clustering accuracy rate of the measured sensor data, but also can be used without additional procedure such as data labeling. It is also efficient at monitoring numerous sensors, managing and verifying sensor data obtained in real time such as smart cities.",book:{id:"9976",slug:"fuzzy-systems-theory-and-applications",title:"Fuzzy Systems",fullTitle:"Fuzzy Systems - Theory and Applications"},signatures:"JaeHyuk Cho",authors:[{id:"329648",title:"Prof.",name:"JaeHyuk",middleName:null,surname:"Cho",slug:"jaehyuk-cho",fullName:"JaeHyuk Cho"}]},{id:"39778",title:"GPS and the One-Way Speed of Light",slug:"gps-and-the-one-way-speed-of-light",totalDownloads:3462,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2387",slug:"new-approach-of-indoor-and-outdoor-localization-systems",title:"New Approach of Indoor and Outdoor Localization Systems",fullTitle:"New Approach of Indoor and Outdoor Localization Systems"},signatures:"Stephan J.G. Gift",authors:[{id:"141106",title:"Prof.",name:"Stephan",middleName:null,surname:"Gift",slug:"stephan-gift",fullName:"Stephan Gift"}]}],onlineFirstChaptersFilter:{topicId:"115",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}]},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:617,paginationItems:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},onlineFirstChapters:{},publishedBooks:{},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/77919",hash:"",query:{},params:{id:"77919"},fullPath:"/chapters/77919",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()