Chapter 1: "Permanent Maxillary and Mandibular Incisors"\n
Chapter 2: "The Permanent Maxillary and Mandibular Premolar Teeth"\n
Chapter 3: "Dental Anatomical Features and Caries: A Relationship to be Investigated"\n
Chapter 4: "Anatomy Applied to Block Anaesthesia"\n
Chapter 5: "Treatment Considerations for Missing Teeth"\n
Chapter 6: "Anatomical and Functional Restoration of the Compromised Occlusion: From Theory to Materials"\n
Chapter 7: "Evaluation of the Anatomy of the Lower First Premolar"\n
Chapter 8: "A Comparative Study of the Validity and Reproducibility of Mesiodistal Tooth Size and Dental Arch with the iTero Intraoral Scanner and the Traditional Method"\n
Chapter 9: "Identification of Lower Central Incisors"\n
The book is aimed toward dentists and can also be well used in education and research.',isbn:"978-1-78923-511-1",printIsbn:"978-1-78923-510-4",pdfIsbn:"978-1-83881-247-8",doi:"10.5772/65542",price:119,priceEur:129,priceUsd:155,slug:"dental-anatomy",numberOfPages:204,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"445cd419d97f339f2b6514c742e6b050",bookSignature:"Bağdagül Helvacioğlu Kivanç",publishedDate:"August 1st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/5814.jpg",numberOfDownloads:13239,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:8,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:12,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 4th 2016",dateEndSecondStepPublish:"October 25th 2016",dateEndThirdStepPublish:"July 16th 2017",dateEndFourthStepPublish:"August 16th 2017",dateEndFifthStepPublish:"October 16th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"178570",title:"Dr.",name:"Bağdagül",middleName:null,surname:"Helvacıoğlu Kıvanç",slug:"bagdagul-helvacioglu-kivanc",fullName:"Bağdagül Helvacıoğlu Kıvanç",profilePictureURL:"https://mts.intechopen.com/storage/users/178570/images/7646_n.jpg",biography:"Bağdagül Helvacıoğlu Kıvanç is a dentist, a teacher, a researcher and a scientist in the field of Endodontics. She was born in Zonguldak, Turkey, on February 14, 1974; she is married and has two children. She graduated in 1997 from the Ankara University, Faculty of Dentistry, Ankara, Turkey. She aquired her PhD in 2004 from the Gazi University, Faculty of Dentistry, Department of Endodontics, Ankara, Turkey, and she is still an associate professor at the same department. She has published numerous articles and a book chapter in the areas of Operative Dentistry, Esthetic Dentistry and Endodontics. She is a member of Turkish Endodontic Society and European Endodontic Society.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"174",title:"Dentistry",slug:"dentistry"}],chapters:[{id:"56461",title:"Permanent Maxillary and Mandibular Incisors",doi:"10.5772/intechopen.69542",slug:"permanent-maxillary-and-mandibular-incisors",totalDownloads:2541,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The permanent incisors are the front teeth that erupt between 6 and 8 years of age. They are eight in number, four upper and four lower, two centrals and two laterals. They have sharp biting surfaces designed for shearing and cutting of food materials into small chewable pieces. They are the teeth most visible to the others during eating, smiling and talking, and thus, they have high aesthetic value for the individuals. The unique characteristics, arch position, function, development and chronological age of each tooth will be highlighted. In addition, the different aspects with their geometric outlines, outlines and surface anatomy of these teeth will be described. A brief explanation about the pulp cavity, tooth socket and normal occlusion for each tooth will be included.",signatures:"Mohammed E. Grawish, Lamyaa M. Grawish and Hala M. Grawish",downloadPdfUrl:"/chapter/pdf-download/56461",previewPdfUrl:"/chapter/pdf-preview/56461",authors:[{id:"82989",title:"Prof.",name:"Mohammed",surname:"Grawish",slug:"mohammed-grawish",fullName:"Mohammed Grawish"}],corrections:null},{id:"62386",title:"The Permanent Maxillary and Mandibular Premolar Teeth",doi:"10.5772/intechopen.79464",slug:"the-permanent-maxillary-and-mandibular-premolar-teeth",totalDownloads:2717,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The permanent premolar teeth are placed between the anterior teeth and molars. Eight premolars are found in the permanent dentition, four per arch and two in each quadrant. The main function of premolars is to assist the canines in regard to tear and pierce the food and supplement the grinding of the molars during mastication. The other functions are to support the corners of the mouth reinforce esthetics during smiling and maintain the vertical dimension. Detailed morphology of the permanent premolar teeth is narrated in a pointwise and systematic manner in this chapter.",signatures:"Işıl Çekiç Nagaş, Ferhan Eğilmez and Bağdagül Helvacioğlu Kivanç",downloadPdfUrl:"/chapter/pdf-download/62386",previewPdfUrl:"/chapter/pdf-preview/62386",authors:[{id:"178570",title:"Dr.",name:"Bağdagül",surname:"Helvacıoğlu Kıvanç",slug:"bagdagul-helvacioglu-kivanc",fullName:"Bağdagül Helvacıoğlu Kıvanç"}],corrections:null},{id:"57546",title:"Dental Anatomical Features and Caries: A Relationship to be Investigated",doi:"10.5772/intechopen.71337",slug:"dental-anatomical-features-and-caries-a-relationship-to-be-investigated",totalDownloads:1665,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Dental caries is a multifactor disease affecting a significant number of people throughout the world. However, in recent decades the widespread availability of fluoride and other preventive measures have resulted in a decline in the prevalence of caries among children and young adults. Currently, it is accepted that most carious dental lesions are restricted to specific anatomical sites. The aim of this chapter is to review the influence of dental anatomy on dental caries development while taking into account recent findings in cariology. Occlusal fissures in the first permanent molar are generally the first sites in the permanent dentition to develop caries. An increased risk of caries is also found in proximal contacting surfaces between two adjacent teeth. Moreover, a partially erupted tooth, which does not participate in mastication, is also at risk for caries since it may provide a more favorable environment for bacterial accumulation than a fully erupted tooth. Bacterial biofilm on the tooth is frequently a high risk caries environment. Understanding anatomical dental features is of great importance for guiding oral health hygiene and preventive measures. Finally, the development of dental disorders plays an important role in dental caries risk.",signatures:"Marcel Alves Avelino de Paiva, Dayane Franco Barros Mangueira\nLeite, Isabela Albuquerque Passos Farias, Antônio de Pádua\nCavalcante Costa and Fábio Correia Sampaio",downloadPdfUrl:"/chapter/pdf-download/57546",previewPdfUrl:"/chapter/pdf-preview/57546",authors:[{id:"138852",title:"Prof.",name:"Fabio",surname:"Sampaio",slug:"fabio-sampaio",fullName:"Fabio Sampaio"},{id:"213662",title:"Prof.",name:"Isabela Albuquerque",surname:"Passos Farias",slug:"isabela-albuquerque-passos-farias",fullName:"Isabela Albuquerque Passos Farias"},{id:"213663",title:"Prof.",name:"Dayane Franco",surname:"Barros Mangueira Leite",slug:"dayane-franco-barros-mangueira-leite",fullName:"Dayane Franco Barros Mangueira Leite"},{id:"213664",title:"BSc.",name:"Marcel Alves",surname:"Avelino De Paiva",slug:"marcel-alves-avelino-de-paiva",fullName:"Marcel Alves Avelino De Paiva"},{id:"213666",title:"Prof.",name:"Antonio De Pádua",surname:"Cavalcante Da Costa",slug:"antonio-de-padua-cavalcante-da-costa",fullName:"Antonio De Pádua Cavalcante Da Costa"}],corrections:null},{id:"56119",title:"Anatomy Applied to Block Anesthesia for Maxillofacial Surgery",doi:"10.5772/intechopen.69545",slug:"anatomy-applied-to-block-anesthesia-for-maxillofacial-surgery",totalDownloads:1506,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Anatomy is a basic knowledge that every clinician must have; however, its full management is not always achieved and gaps remain in daily practice. The aim of this chapter is to emphasize the most relevant aspects of head and neck anatomy, specifically related to osteology and neurology for the application of regional anesthesia techniques. This chapter presents a clear and concise text, useful for both undergraduate and graduate students and for the dentist and maxillofacial surgeon. The most relevant aspects of the bone and sensory anatomy relevant for the realization of regional anesthetic techniques in the oral and maxillofacial area are reviewed, including complementary figures and tables. The anatomy related to the techniques directed to the three major branches of the trigeminal nerve (ophthalmic nerve, maxillary nerve, and to the branches of the mandibular nerve) will be approached separately.",signatures:"Alex Vargas, Paula Astorga and Tomas Rioseco",downloadPdfUrl:"/chapter/pdf-download/56119",previewPdfUrl:"/chapter/pdf-preview/56119",authors:[{id:"199400",title:"Dr.",name:"Alex",surname:"Vargas",slug:"alex-vargas",fullName:"Alex Vargas"},{id:"202023",title:"Dr.",name:"Paula",surname:"Astorga",slug:"paula-astorga",fullName:"Paula Astorga"},{id:"205059",title:"Dr.",name:"Tomas",surname:"Rioseco",slug:"tomas-rioseco",fullName:"Tomas Rioseco"}],corrections:null},{id:"55902",title:"Treatment Considerations for Missing Teeth",doi:"10.5772/intechopen.69543",slug:"treatment-considerations-for-missing-teeth",totalDownloads:961,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Specific terms are used to describe the nature of tooth agenesis. Hypodontia is most frequently used when describing the phenomenon of congenitally missing teeth. Many other terms to describe a reduction in the number of teeth appear in the literature: oligodontia, anodontia, aplasia of teeth, congenitally missing teeth, absence of teeth, agenesis of teeth and lack of teeth. The term hypodontia is used when one to six teeth, excluding third molars, are missing, and oligodontia when more than six teeth are absent (excluding the third molars). The long‐term management of hypodontia in the aesthetic zone is a particularly challenging situation. Although there are essentially two distinct approaches to manage this problem, that is space closure or opening for prosthetic replacements, implant or autotransplantation. These patients often manifest with many underlying skeletal and dental problems and a multidisciplinary approach for management of this condition is recommended. Two treatment approaches including space closure and space reopening are described in details in this chapter.",signatures:"Abdolreza Jamilian, Alireza Darnahal, Ludovica Nucci, Fabrizia\nD’Apuzzo and Letizia Perillo",downloadPdfUrl:"/chapter/pdf-download/55902",previewPdfUrl:"/chapter/pdf-preview/55902",authors:[{id:"171777",title:"Prof.",name:"Abdolreza",surname:"Jamilian",slug:"abdolreza-jamilian",fullName:"Abdolreza Jamilian"},{id:"171873",title:"Dr.",name:"Alireza",surname:"Darnahal",slug:"alireza-darnahal",fullName:"Alireza Darnahal"},{id:"173044",title:"Prof.",name:"Letizia",surname:"Perillo",slug:"letizia-perillo",fullName:"Letizia Perillo"},{id:"198961",title:"MSc.",name:"Fabrizia",surname:"D'Apuzzo",slug:"fabrizia-d'apuzzo",fullName:"Fabrizia D'Apuzzo"},{id:"206137",title:"Mrs.",name:"Ludovica",surname:"Nucci",slug:"ludovica-nucci",fullName:"Ludovica Nucci"}],corrections:null},{id:"55973",title:"Anatomical and Functional Restoration of the Compromised Occlusion: From Theory to Materials",doi:"10.5772/intechopen.69544",slug:"anatomical-and-functional-restoration-of-the-compromised-occlusion-from-theory-to-materials",totalDownloads:1248,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Many conditions can alter the occlusal interface, from tooth wear to tooth loss. The masticatory system is constituted by many components that can influence each other like muscles, joints, teeth and nervous system. This implies that (a) every change at occlusal level makes the other components to adapt and (b) an occlusal alteration may be the effect of an alteration occurred on muscles or joints. Keeping this in mind, traditional principles of occlusal rehabilitation are analysed, and the choice of the restorative materials is discussed.",signatures:"Nicola Mobilio and Santo Catapano",downloadPdfUrl:"/chapter/pdf-download/55973",previewPdfUrl:"/chapter/pdf-preview/55973",authors:[{id:"179565",title:"Dr.",name:"Nicola",surname:"Mobilio",slug:"nicola-mobilio",fullName:"Nicola Mobilio"},{id:"199397",title:"Prof.",name:"Santo",surname:"Catapano",slug:"santo-catapano",fullName:"Santo Catapano"}],corrections:null},{id:"57245",title:"Evaluation of the Anatomy of the Lower First Premolar",doi:"10.5772/intechopen.71038",slug:"evaluation-of-the-anatomy-of-the-lower-first-premolar",totalDownloads:877,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter provides information about the lower first premolars. This tooth is considered to be one of the most complex teeth and the dentistry graduation students usually have difficulties in identifying it. The aim of this chapter is to present a detailed morphological study of extracted lower first premolars. One hundred lower first premolars, belonging to the collection of the Laboratory of Anatomy of the Department of Morphology of the São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil, were evaluated. Nine measurements were performed through direct observation without any instruments. Other 20 measurements were made by photographs and they were analyzed by the Image Tool 3.0 program. According to the results, it was concluded that most of the teeth presented the following features such as one lingual cusp; the distal occlusal pits were wider than the mesial occlusal pits; an enamel bridge linking the buccal and lingual cusps; the grooves in the lingual surface that emerged from the mesial and distal occlusal pits were absent, and where the grooves were present, they emerged from the mesial occlusal pit; one rectilinear root with no root grooves and where the root groove was present, it was observed in the mesial surface.",signatures:"Ticiana Sidorenko de Oliveira Capote, Suellen Tayenne Pedroso\nPinto, Marcelo Brito Conte, Juliana Álvares Duarte Bonini Campos\nand Marcela de Almeida Gonçalves",downloadPdfUrl:"/chapter/pdf-download/57245",previewPdfUrl:"/chapter/pdf-preview/57245",authors:[{id:"87871",title:"Prof.",name:"Ticiana",surname:"Capote",slug:"ticiana-capote",fullName:"Ticiana Capote"},{id:"199157",title:"Prof.",name:"Marcela",surname:"De Almeida Gonçalves",slug:"marcela-de-almeida-goncalves",fullName:"Marcela De Almeida Gonçalves"},{id:"199243",title:"BSc.",name:"Marcelo",surname:"Brito Conte",slug:"marcelo-brito-conte",fullName:"Marcelo Brito Conte"},{id:"199244",title:"Prof.",name:"Juliana",surname:"Álvares Duarte Bonini Campos",slug:"juliana-alvares-duarte-bonini-campos",fullName:"Juliana Álvares Duarte Bonini Campos"},{id:"217420",title:"Mrs.",name:"Suellen",surname:"Tayenne Pedroso Pinto",slug:"suellen-tayenne-pedroso-pinto",fullName:"Suellen Tayenne Pedroso Pinto"}],corrections:null},{id:"57752",title:"A Comparative Study of the Validity and Reproducibility of Mesiodistal Tooth Size and Dental Arch with iTeroTM Intraoral Scanner and the Traditional Method",doi:"10.5772/intechopen.70963",slug:"a-comparative-study-of-the-validity-and-reproducibility-of-mesiodistal-tooth-size-and-dental-arch-wi",totalDownloads:894,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Introduction: The introduction of intraoral scanning offers an alternative for measuring mesiodistal tooth sizes.",signatures:"Ignacio Faus-Matoses, Ana Mora, Carlos Bellot-Arcís, Jose Luis\nGandia-Franco and Vanessa Paredes-Gallardo",downloadPdfUrl:"/chapter/pdf-download/57752",previewPdfUrl:"/chapter/pdf-preview/57752",authors:[{id:"150456",title:"Prof.",name:"Vanessa",surname:"Paredes",slug:"vanessa-paredes",fullName:"Vanessa Paredes"},{id:"150458",title:"Prof.",name:"José-Luis",surname:"Gandia-Franco",slug:"jose-luis-gandia-franco",fullName:"José-Luis Gandia-Franco"},{id:"212242",title:"Prof.",name:"Ignacio",surname:"Faus",slug:"ignacio-faus",fullName:"Ignacio Faus"},{id:"212243",title:"Prof.",name:"Carlos",surname:"Bellot-Arcís",slug:"carlos-bellot-arcis",fullName:"Carlos Bellot-Arcís"},{id:"218390",title:"Prof.",name:"Ana",surname:"Mora",slug:"ana-mora",fullName:"Ana Mora"}],corrections:null},{id:"57378",title:"Identification of Lower Central Incisors",doi:"10.5772/intechopen.71341",slug:"identification-of-lower-central-incisors",totalDownloads:837,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Unlike the other teeth, the permanent lower central incisors have great symmetry between the proximal surfaces, being difficult to distinguish them. It was intended to facilitate the study of the anatomy of the lower central incisor for dentistry students, that this study searched for a better way to differentiate the third quadrant element (31) from the fourth quadrant element (41). The purpose of this chapter was to evaluate 100 permanent lower central incisors of the didactic collection of the Discipline of Anatomy of the Department of Morphology of the School of Dentistry of Araraquara - UNESP and to verify the presence of correlation between the some anatomical features. Besides, it was evaluated if there was difference between 31 and 41. It was verified that the systematic methodology used for the evaluation of the incisors in this study facilitated the identification of the teeth. There was no statistically significant difference between the measurements of 31 and 41. Distinguishing the right from the left central incisor is difficult, even for experienced practitioners. We could observe that the measurements do not facilitate the identification of teeth of different quadrants. Therefore, the anatomical features are relevant for the study of the dental anatomy in the identification of the lower central incisors.",signatures:"Marcela de Almeida Gonçalves, Bruno Luís Graciliano Silva, Marcelo\nBrito Conte, Juliana Álvares Duarte Bonini Campos and Ticiana\nSidorenko de Oliveira Capote",downloadPdfUrl:"/chapter/pdf-download/57378",previewPdfUrl:"/chapter/pdf-preview/57378",authors:[{id:"199157",title:"Prof.",name:"Marcela",surname:"De Almeida Gonçalves",slug:"marcela-de-almeida-goncalves",fullName:"Marcela De Almeida Gonçalves"},{id:"199243",title:"BSc.",name:"Marcelo",surname:"Brito Conte",slug:"marcelo-brito-conte",fullName:"Marcelo Brito Conte"},{id:"199244",title:"Prof.",name:"Juliana",surname:"Álvares Duarte Bonini Campos",slug:"juliana-alvares-duarte-bonini-campos",fullName:"Juliana Álvares Duarte Bonini Campos"},{id:"221435",title:"Mr.",name:"Bruno Luis Graciliano",surname:"Silva",slug:"bruno-luis-graciliano-silva",fullName:"Bruno Luis Graciliano Silva"},{id:"221438",title:"Prof.",name:"Ticiana Sidorenko De Oliveira",surname:"Capote",slug:"ticiana-sidorenko-de-oliveira-capote",fullName:"Ticiana Sidorenko De Oliveira Capote"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"7cb94732cfb315f8d1e70ebf500eb8a9",slug:"trauma-in-dentistry",bookSignature:"Serdar Gözler",coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",editedByType:"Edited by",editors:[{id:"204606",title:"Dr.",name:"Serdar",surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8837",title:"Human Teeth",subtitle:"Key Skills and Clinical Illustrations",isOpenForSubmission:!1,hash:"ac055c5801032970123e0a196c2e1d32",slug:"human-teeth-key-skills-and-clinical-illustrations",bookSignature:"Zühre Akarslan and Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/8837.jpg",editedByType:"Edited by",editors:[{id:"171887",title:"Prof.",name:"Zühre",surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan"}],equalEditorOne:{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui",profilePictureURL:"https://mts.intechopen.com/storage/users/52177/images/system/52177.png",biography:"Prof. Farid Bourzgui obtained his DMD and his DNSO option in Orthodontics at the School of Dental Medicine, Casablanca Hassan II University, Morocco, in 1995 and 2000, respectively. Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9588",title:"Clinical Concepts and Practical Management Techniques in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"42deab8d3bcf3edf64d1d9028d42efd1",slug:"clinical-concepts-and-practical-management-techniques-in-dentistry",bookSignature:"Aneesa Moolla",coverURL:"https://cdn.intechopen.com/books/images_new/9588.jpg",editedByType:"Edited by",editors:[{id:"318170",title:"Dr.",name:"Aneesa",surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10126",title:"Dental Caries",subtitle:null,isOpenForSubmission:!1,hash:"0878a332413e67a1aa0a16fabeed9046",slug:"dental-caries",bookSignature:"Efka Zabokova Bilbilova",coverURL:"https://cdn.intechopen.com/books/images_new/10126.jpg",editedByType:"Edited by",editors:[{id:"275097",title:"Associate Prof.",name:"Efka",surname:"Zabokova Bilbilova",slug:"efka-zabokova-bilbilova",fullName:"Efka Zabokova Bilbilova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9387",title:"Oral Diseases",subtitle:null,isOpenForSubmission:!1,hash:"76591a3bd6bedaa1c8d1f72870268e23",slug:"oral-diseases",bookSignature:"Gokul Sridharan, Anil Sukumaran and Alaa Eddin Omar Al Ostwani",coverURL:"https://cdn.intechopen.com/books/images_new/9387.jpg",editedByType:"Edited by",editors:[{id:"82453",title:"Dr.",name:"Gokul",surname:"Sridharan",slug:"gokul-sridharan",fullName:"Gokul Sridharan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"1e9812cebd46ef9e28257f3e96547f6a",slug:"computer-vision-in-dentistry",bookSignature:"Monika Elzbieta Machoy",coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",editedByType:"Edited by",editors:[{id:"248279",title:"Dr.",name:"Monika",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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The essence of increasing the life span of information stored in papers containing resources of permanent value is to digitise. The pervasive and proliferating digital transformation requires organisations with the agility and the ability to react quickly to changes in the business environment [1]. Digitisation is an innovation brought about as a result of developments in computerised technology that can convert papers to an electronic format that is more permanent and devoid of environmental hazard that can eclipse the life span of information stored in the paper [2]. Theoretically, the procedure of digitisation entails converting an analogue image and other media its equivalent electronic format. In the context of this article, some of the vital issues like, the selection of documents, the scanning and image capture, arranging metadata and arranging for required hardware and software selection are essential for the development of digitisation workflow [3].
With the development of digitalization in full swing, many are pondering how the implementation of the new digital distruptive technologies will spur and inspire the creation of new jobs and destruction. The specific tasks that technologies take on and how many new jobs the created of others. Through the adoption of new digital technologies. Some maintained that most tasks that are at risk of automation are those performed is an area for concern for policy makers in government, industry, higher education and civil society by rather low- to medium-skilled employees, while most new tasks that emerge from the adoption of digital technologies complement high-skilled labor [4].
Elaiess [5] and Arms [6] viewed a digital library as a systematically managed collection of information with allied services, where the information is stored in digital formats and reachable over the Internet. Witten and Bainbridge [7] highlighted the following as the key features of a digital library:
Prearranged and managed a collection of digital objects;
Available, accessible or obtainable over the Internet or server;
A universal information infrastructure; and
Provides service to users.
Kane et al. [8] defined digital maturity as the extent digitisation has transformed the processes, talent engagement and business models of an organisation. The indicators of including, digital maturity include;
The clear and coherent digital strategy incorporated, with the ability to articulate the value of digital technologies to the organisational future;
Comfort in taking risks and embracing failure as a prerequisite for success; and
Investment in organisational capabilities.
Shuva [9] argued that in the era of digital technologies, a digital library has become one of the most frequently used terms in the library and information science arena. Digital libraries have become the magic bullet to rescue governments, academic institutions, industry and users from the COVID-19 pandemic regulations which prevents physical contacts and encourages social distancing. Such techno-centric institutions refer to systems that are very heterogeneous in scope and provide different functions. These systems range from digital objects and metadata repositories, reference-linking systems, archives, and content administration systems to complex systems that integrate advanced digital systems [9]. Libraries are information systems whether traditional or modern because they collect, process, store, analyse and disseminate information for specific purposes to specific user groups [10].
Tihinen et al. [1] viewed digitalisation as one of the prominent trends transforming the information landscape, society and business in the near and long term future. Digitalisation refers to the action or process of digitising; the conversion of analogue data into digital form [1]. Digitalisation is the critical enabling issue for providing internal efficiency in organisations, or for delivering external opportunities such as new services or offerings to customers [1]. The use of various digital technologies has become a core mission of libraries and related institutions [11]. Belhi et al. [12] argued that the wide adoption of information technology obliges organisations to adapt its resources to be part of the digital era. According to the authors, the high development pace of technology has resulted in the fear of digital obsolescence as a critical factor than the fear of physical data loss. Digital obsolescence, or data extinction, refers to the state whereby the archived data becomes no more readable or usable [12]. The files meant to be read or edited with a certain programs (e.g. Microsoft Word) might be illegible in other programs, and as operating systems and hardware changes, even old types of programs developed by the same company become difficult to use on the new platform.
Libraries as cultural institutions accommodate treasured documents, as a result, must carefully consider digitisation as a way to preserving the information resources to circumvent the loss of the originals, this is the position of modern librarians. Usually, in the library environment, digitisation comprises of scanning, photographing analogous pieces like cherished books, maps, manuscripts, correspondence, which are considered but not limited to as rare, exceptional, and tremendously delicate collections, and then transforming these resources into a digital environment where the lifespan can be permanent and the integrity preserved [13].
Digitalisation has many recognisable advantages such as instant accessibility to information, easy and speedy communication and capacity to share and exchange information, the generation of new jobs, better opportunities, and increased transparency and visibility [14]. The aim of digitisation is to improve access and advance preservation [15]. Digitalisation enables libraries and related institutions to provide virtual access to content in order to ensure the discoverability and the retrievability of the content and enhance the preservation of the content by avoiding the wear and tear of original works. The proliferation of digital technologies and the drive towards the fourth industrial revolution (4IR) should be viewed as an opportunity for libraries and related institutions to improve services to users by responding to their dynamic needs by adapting the innovative emerging digital technologies including Virtual Reality (VR).
The Digitization Workflow is an approach to explain the step by step arrangement of digitising information resources to accomplish the process of digitisation including its various phases, like the process of material selection, preparation of documents, scanning/OCR use scanner, processing for editing, quality assurance, metadata and indexing, back-up and archiving, publishing in a digital repository and finally checking out. The rationale of this workflow is to provide history tracking of actions and flexibility to accomplish multiple projects with multiplicity and diversity of materials concurrently. Additionally, it supports the convinient assimilation of tools used to implement the functions of the workflow. Optical Character Recognition (OCR) is a technology that allows the conversion of diverse types of the documents and materials, such as PDF files or images captured by the use of a digital camera into editable and searchable data formats [16].
The first stage of digitization is document selection which requires expertise in knowing which documents to include and for what reasons. The preparation of document is key to enable selected documents a flawless procedure that is devoid of office objects such as: document clips, sticky notes, pins and spiral bind. Scanning/OCR (Optical Character Recognition) is the conversion of physical documents to electronic format which requires the use of highly efficient, reliable and speedy electronic scanning machine. Optical Character Recognition is used in converting images, handwritten or printed text into machine-encoded text, whether from a scanned document, this is important because it will make the document searchable and easy to locate and retrive from online. The integrity of the document it is of paramount importance in order to ensure quality assurance of the document by properly editing the information content so that the document will be free from both content and grammatical errors. The final stage of the digitization process is to ensure back-up and archiving this will guarantee the security of the document and information content, in case of hacking, social engineering, cross-site scripts virus attack or other unforeseen problem that might compromise the integrity of the document [17]. These are the step by step procedure of digitization workflow before finally publishing the content to make it visible within the local network and its availability and accessibility on the internet for the benefit of the general public (Figure 1).
Digitalisation workflow chart.
The Digitization Workflow is an approach to explain the step by step arrangement of digitising information resources to accomplish the process of digitisation including its various phases, like the process of material selection, preparation of documents, scanning/OCR use scanner, processing for editing, quality assurance, metadata and indexing, back-up and archiving, publishing in a digital repository and finally checking out. The rationale of this workflow is to provide history tracking of actions and flexibility to accomplish multiple projects with multiplicity and diversity of materials concurrently. Additionally, it supports easy assimilation of tools used to implement functions of the workflow. Optical Character Recognition (OCR) is a technology that allows the conversion of diverse types of documents and materials, such as PDF files or images captured by the use of a digital camera into editable and searchable data format [16].
Abollado et al. [18] noted that while digital workflows are a suitable solution for managing business processes complexity in the engineering industry, it is equally essential to be aware of all the challenges that are associated with implementing a workflow system. Such grandiose projects require concrete management engagement, end-user involvement, tools and system integration and a sensible implementation plan. Abollado et al. [18] observations were drawn from the engineering sector, but they apply to library science with regards to the ongoing digitisation projects.
Digital workflow projects underpin organisational performance. The previous phases of a workflow project are generally more critical to the overall success of the project. There are several recommended practices for implementing a successful workflow management system in an aerospace company, for example, obtaining the support of senior management, integrating the digital workflow with current techniques and securing the support of end-users who are also key stakeholders [18].
The digital workflows and workflow management tools offer an opportunity to improve, automate and streamline the underlying processes in any business, including the library [19]. Such projects help to enhance communications, among others, benefit—performance, accountability and visibility. The essential criteria for selection for digitisation are the copyright status of the original materials. Images are supposed to have their copyright held by the establishment. If the organisation does not have the right to digitise, then other images must be chosen, or the project cannot proceed for fear of litigation. Preparation of the digitisation process includes reviewing the procedures in place from the beginning to the end of the process of production facility up to the final delivery digital images and data back. Other important aspects of the digitisation workflow includes generating indexing and keyword to includes convinient information accessibility and precision. It is vital to ensure quality control so that the output will be acceptable to the general public and meet international standards. To securing data and enable the integrity of the information is vital, data encrypted and securely kept to guard against loss of information [20].
Content digitalization has becoming an established enterprise in the information age, giving birth too many innovative business ideas, models and much more. This has led to numerous disciplines and industries taking advantage of its opportunities and broadening and widening access to organisational resources. As a result of several advances in information and communication technologies many organizations have adapted to digital models driving the new digital era.
The general misunderstanding is that to digitize a material is the same as digital preservation. To digitize material is the act of converting something from an analog to a digital format. For instance, scanning a photograph and retaining a digital copy on a computer. This is basically the first step in digital preservation. To digitally preserve a material is to prolong the content over a long time [21].
Several galleries, libraries, archives, and museums (GLAMs), and other cultural institutions, undergo uphill task catching up and up to date in digital preservation. Digitization is a onerous and time-consuming activities, mostly because it is contingent on the critical condition of the holdings previous to the time of digitized. The possibility exist that the materials may be fragile and delicate that if care is not taken the information resources may be lost or become damaged irreparably; light emanating from the scanner can destroy old photographs papers and documents. Notwithstanding the potential damage, one rationale for content digitization is as a result of constant use of a material, therefore, digitization will preserve the original copy from total degeneration [22].
The process of digitization is relatively expensive. Organizations ensure best quality in digital copies by retaining the best possible. Raising money to meet the expense required for the equipment is another major challenge. The quality of personnel may also limit the process of digitization. Archivists and librarians must be familiar with the aspirations and desires of their patrons and try to prioritize and meet the needs digitally [22].
The International Federation of Library Associations and Institutions (IFLA, 2000) [23] a foremost international body representing the interests of libraries and information professionals, in a report in 2000 identified guidelines for digital project, which has become popular in setting standard for the implementation and practice of digitization. Regardless of this standard, studies of digitization shows that it is rarely utilized as standards for evaluation [24].
The formulation of selection policies is a fundamental element of digital schemes, and various selection guidelines and standards have been established by organizations to authenticate their selection processes for digitization regarding external benchmarks, particularly with the growth of partnerships for digital projects. It is important to prioritize the materials to digitize based on the need of the patron, usage of information material is an alternative factor which helps to decide a collection’s priority for digitization [25].
The technical Standards for digitization requires to sourcing records in line with best practice and technical standards when the digitized record is projected to stand in place of the source record as the official record of information resources [26].
There are steps to follow in the implementation of digitization projects, determining the vision for implementing digital transformation, analyzing the market by determining the needs of the patron because of quick technology improvement and industry modifications, are crucial for creating the appropriate and up-to-date strategy. Another step involves assessing the a current standing which is a way to evaluate what technology to update and to identify what digital tools to change will help in prioritizing the efforts and investment in digital transformation strategy in the best possible way [27].
Elaiess [28] and Elaiess [5] viewed the standard development life-cycle (SDLC) as a means to provide the standard methodology and high-level operational guidelines within which software is developed and maintained. It is the process of understanding how an information system can support business needs, designing the system, building it, and delivering it to users. Cervone [29] argued that the system development life-cycle concept had been applied mainly to system development projects for years. Project teams developing digital library systems can be more effective if they understand the expectations and outcomes of each phase of the system development life-cycle [29]. Systems development is the art and science of creating human made information systems to satisfy predetermined needs. The systems development life-cycle can be used for the traditional and the modern library materials with regards to creation, processing, dissemination and preservation. It is a problem-solving process integrates appropriate elements of humankind’s knowledge base to create new knowledge specific to the problem and, as a result, define a solution to the problem. Grenci and Hull [30] highlighted that Information systems development methodologies (ISDM) encompass the sum total of methods that are used for developing and implementing information systems applications. The use of information systems in the organisational environment has been growing in recent times, and this justifies the need for broadening and widening understanding of how such systems operate and how they can benefit libraries and related institutions.
Duarte and Costa [31] viewed Information Systems as important tools to enhance the efficient management of information and other knowledge assets in organisations. The life cycle model is very important because each phase of the process influences the phase after, which means that phases of the life cycle have a great influence on the global success of these systems. Duarte and Costa [31] argued that it was vital to know all the process and its critical success factors to make sure that there are no mistakes. The systems development life cycle must be understood because it underpins the success of a library digitization project. The digitization of libraries is now on the agenda of many academic institutions and governments especially now in the era of the COVID-19 pandemic. The aforementioned processes and procedures of digitalization workflow are useful for the development of digital libraries in the era of the COVID-19 pandemic.
This article presents a substantial academic work highlighting different phases of digitization workflow and the process of electronic or digital conversion of documents. Digitization is important because it helps to enhance data processing, improving data storage, fast-tracking transmission and improving efficient service delivery. It also facilitates data sharing and retrieval, and it has proven to be the most satisfactory way of preserving information for a considerable length of time. This research also simplifies the chain of processes and tasks involved in a digitization project, thus facilitating uniformity and dependable results relating to the digitisation of a large volume of objects. It should be noted that the documentation of the workflow is critical for tracking material within the context of a series of the stages of the process and identifying technical glitches. This article also highlighted some of the challenges of digitization. For instance, damages caused by environmental problems like, earthquake, rainfall, humidity, fire, and other human factors like careless handling, defacement and inappropriate support during storage and cyber threats. The deterioration of library resources like books, journals, and other materials forms the fundamental challenges of libraries which makes preservation and conservation imperative. Finally, this study also revealed the digital lifecycle and its phases through which digitization process go through to attain full conversion and this is the passage of modernization that pursues constant regulations to attain innovative expectations.
According to AlMarshedi et al. [1] the term
In the twentieth century, J. Piaget, and L. Vigotsky started the trend of highlighting the importance of games in human learning and in personal cognitive development. Since then and from the development of their theoretical elaborations, it is understood that learning based on play is concerned with investigating the forms of interaction between play and learning. This produced a way of conceptualizing education that today has a long tradition. However, what those authors could not foresee is the enormous incidence that the vertiginous development of technology has today in every aspect of human life, including education.
Framed in the Internet era, a space of convergence between education, digitality and games arises, giving way to edutainment. According to Shaffer et al. [2] this is described as a type of game with defined learning outcomes. In this context, games present clear objectives that are divided into achievable short-term goals. They give a seamless sense of player progression, providing frequent rewards that act as external motivators.
In addition to motivation, video games provide a fictional context in the form of narratives, graphics and music that foster players’ interest [3]. Due to the improvement of the supporting technology, this interest is furthermore growing for the individual and extends to wider and wider population groups. Because of this potential, a great deal of work has been done on ways in which video games can be successfully used for educational purposes.
According to Mejía and Londoño [4] virtual games represent one of the most important possibilities for learning processes in children and adolescents. They warn that these games can be applied in fields such as the teaching of culture, citizenship, and social sciences, among others. Despite these findings, questions arise about the effectiveness of gamification in education. Most studies and reviews of empirical studies on gamification indicate that they generally have positive effect on motivation and behavior [5, 6, 7, 8].
In gamification, it is generally observed that there is a greater possibility of engagement and ability to connect with intrinsic motivation. This simultaneously favors the production of cognitive, emotional and social benefits [9, 10, 11].
On the other hand, Connolly [12] presents a systematic review of the literature on game-based learning, focusing on the attainment of empirical evidence. In his results, he emphasizes the need for more rigorous evidence of the effectiveness of games and their real impact. This implies a significant questioning of the results and conclusions of previous research on the subject based on the questioning of instruments and techniques of data collection and analysis.
On this situation, it is illustrative the appreciation of Jagušt et al. [13] in which they state that:
Beyond the above, some educational researchers observe this type of entertainment with great interest. De-Marcos et al. [14] asserts that video games are interactive activities that continuously provide challenges and objectives to players. This implies an intentional learning process to acquire progressive mastery of the game mechanics. In the same sense Busch et al. [15] present the results of their experiment. In this experiment, the researchers used games from a web platform for an e-learning experience—gamified—and evaluated it. Their findings suggest that the platform serves as a collaborative database where students could create and answer questions, using it as an alternative way to study and review geography and mathematics topics, among other content.
Thus, it is difficult to judge definitively the positive, negative, or neutral nature of the inclusion of games in educational environments. However, it would seem that research findings are pragmatically divided into two large groups: the first, broad, which usually concludes that games are effective and the second, composed of those who attribute to flaws in the game design and not to the platform itself when the results of the edutainment application are not as expected [5, 6, 7, 8].
Despite these discussions, the educational field is not exempt from the use of video games and in Latin America in particular, the approach to this issue refers to figures of recognized trajectory in the field of communication. In this sense, Orozco et al. [16] argue that the playful part of learning leads to inadvertent learning. They argue that children obtain them from video games, for example, when they are able to remember sequences in the controls, passwords and tricks that allow them to improve their skills or eliminate obstacles in the video game. In other words, even though these games are not intended to educate, they end up doing so.
This way of educating by playing also produces
In this sense of control of variables, Scolari’s [17] conceptualization of some characteristics of edutainment or gamification deserves special attention. In his opinion, these characteristics are fundamental and refer to digitalization, hypertextuality, reticularity, interactivity, and multimediality, to which he then adds virtuality, non-sequentiality and modularity. To these can be added the principle of multiplicity described by Calvino [18]. This approach is consistent with the fact that these processes have “a
This perspective implies the transformation of human thought. This leaves behind univocal explanations, closed models and the great truths consigned in books. From this perspective, knowledge is built from the fragment to the complexity and vice versa, but without a linear order. Thus, knowledge is constituted as a network that is woven in each of the
According to the theoretical review, edutainment implies the design of new educational environments, duly articulated to some objectives and the tools offered by communication to promote the integration of knowledge, dialog, interaction and cognitive development of students. Therefore, it is necessary to adjust the conceptualization inherent to the traditional educational environment, including the notion of
In this order of ideas, the characteristics of the new media and of the current forms of interaction between agents tend to eliminate verticality in the relations between these agents (educational community). In the same way, it cannot continue in the blind acceptance of the book and the teacher as the only legitimizing sources of truth and knowledge [19]. Therefore, instead of incorporating technology into traditional pedagogical processes in a vague and disjointed manner, we should promote a pedagogy that broadens the univocal vision of its functioning. This is achieved when a dialogical perspective is assumed to generate new forms of encounter with society and culture within the framework of the contemporary context, that is, between screens.
It is clear that the full and articulated incorporation of screens, games and, in general, the bet of edutainment in educational institutions, is a major challenge for contemporary educators. However, success in this task surely allows for new ways of accessing and generating information and knowledge. Edutainment makes educational events more flexible, transforms, changes perspectives, and extends the scope of educational events. In short, it promotes the search for new alternatives in a series of variables and dimensions of the educational act.
This leads to the delocalization of knowledge for the use of different communication tools and for the interaction with different types of codes and symbolic systems. As the most important achievement, edutainment also leads to the choice of the formative itinerary, of strategies and techniques for training and to the convergence that favors access to multiple sources of information. Finally, with this form of screen incorporation, different forms of content, but also of human relations, are complexified and articulated.
Precisely, the incidence of this tool in social interaction forces us to proceed with caution. Buckley and Doyle [20] suggest that the research carried out so far on the effectiveness of edutainment in an educational context should be assumed with prudent caution rather than with absolute optimism. To this end, more and more comprehensive research is required to examine the variables involved in the educational process and the context in which it takes place; learning styles or personality traits, for example, are part of these variables. Their consideration is important because sometimes success can be mistakenly attributed to an edutainment strategy that can be better explained in terms of these variables.
In summary, more research is needed, but especially longitudinal research. With this, it is possible to demonstrate with empirical evidence the relationship between the use of the tool and the behavior generated during the game in students to make valid inferences [16, 20]. It is equally important to clarify that edutainment does not get to build an experience through mechanisms based on theoretical frameworks. It uses aspects of play mechanisms to mediate an activity. It may include motivation or competition (which are game mechanisms), but it does not go so far as to include mechanisms based on social theories in an intentional or specific way.
According to González and Blanco [21], emotions can have a positive or negative influence on learning and, above all, on the motivation to learn. Whether or not a student feels motivated to learn something is one of the keys to autonomous learning. In a similar vein, Domínguez et al. [22] insist that it is necessary to focus on the fundamental elements that make games attractive in order to create an edutainment system that increases student motivation. In the same sense, although for them the reward system is not the only element, it is highly significant.
At this point, the issue that calls is the emotional aspect and the impact that this aspect would have on the tendency to do or repeat something. On this issue.
Csikszentmihalyi [23] highlights that the fact of experiencing the notion of success depends on the ability to concentrate on something. This concentration must be sufficiently intense to lead the individual to abstract from himself and the situation he is living. In this state and in the same sense, this sensation is accompanied by another of clarity in relation to what one would like to do next, due to the immediate feedback offered by the experience itself. All of this is framed in the full conviction of how possible it is to accomplish the task, even if it might be difficult or arduous. When players set out to accomplish the goal that the tasks entail, the natural tendency is to stay with the activity with a high attitude and positive emotional response.
Games also tend to incorporate reward systems that promote and enhance positive attitudes and emotions, giving immediate recognition to the player’s success. It is usual to use reward systems for points, trophies or items that can be acquired for the development of more complex tasks within the same game. Similarly, in the opposite case, that is, when a task is not successfully completed, the player is expected to experience some anxiety.
A certain degree of anxiety is acceptable, but it should be avoided as much as possible to turn it into frustration, as this could lead to abandonment of the game. To avoid this, it is preferable to design the sequence of tasks to suit the skills of the player at any level. It is also advisable that the penalty for each failure be significant enough to be recorded, but also low enough to ensure repeated attempts to complete the tasks. If this transition between failures and successes occurs in a balanced way it is very likely that the player will acquire a level of performance that is, in itself, highly motivating and promotes a balance in emotional tension.
Van Roy and Zaman [24] measured the effects on emotions and motivation of games. They analyzed a 15-week university master’s course in which students interacted voluntarily with a gamified platform. Their results highlight a potential for ambivalent motivation toward the game elements incorporated into the platform. In some cases, they enhanced feelings of autonomy, competence and relatedness. In other cases, frustration was a priority.
As a derivation of the study, the authors suggest that this ambivalent motivation depends directly on some situational factors that play an important role in this process. Finally, it can be concluded that there are several factors involved in the positive or negative emotional impact of the use of gamification. Some are intrinsic, that is, they depend on the subjects who participate in the game (personality, emotional stability, etc.).
Others depend on the structure of the game, the relationships that are established with peers, the mediation of the teacher and even the culture and the way in which social ties have been woven in each human group participating in the process.
Screens have transformed human relationships, but in relation to human interaction, what good has it done? For Petrucco and Agostini [25] the measuring stick is essentially that of Vygotsky. According to her, humans learn from our surrounding world through instruments and artifacts that increase the zone of proximal development. Screens are, of course, part of these instruments and can—perhaps should—be linked to the very design of educational environments as something more than a simple medium. This implies the possibility of constructing spaces for learning or knowledge construction that are based in an important way on social interaction.
This appreciation is theoretically sustained in the formulation of the genetic law of cultural development proposed by Vygotsky [26] where he assures that:
Taking this assertion to the field of the development of educational events, this law leads to the acceptance, as a principle, that all higher functions of human intelligence originate from relationships between human beings. The medium for this interaction is based on language. This means that the dialog, the collaborative workspace, and the interpellation to the other propitiates the introjection and consequently the learning.
Monereo [27] argues that the intrapsychological mental scenario should also be treated as a space of dialog, that is, as an interpsychological space. This space arises in games, be it in the manner of an opponent, a playmate, team, etc. Caillois [28] proposed that, no matter how antigregarious a game or the devices used, a competitor or opponent is required. Thus, from the social aspect, the game institutes a link between subjects. Competition, the exploration of tactics and the tension that this generates are present in social actions as part of a culture that seeks to establish relations of interaction with the other.
A derivation of this social condition consequently refers to the issue of collective performance. According to Jenkins et al. [29] this makes it necessary to explore the culture of convergence. In this conceptual framework, the concepts of collective participation and collective intelligence are articulated. Convergence is defined by Jenkins et al. [29] as the space where the old and the new converge. In this space, different content and different media platforms mix, where technological transformations with their concerning cultural and social consequences follow one another. They include subjects who search for information and make connections between different content spread across networks and media platforms. Jenkins et al. [29] also propose that in participation producers and consumers converge, transforming the passive role of the media spectator. Thus, participation-mediated convergence occurs in the brains of individual consumers and through their social interactions with others.
On the other hand, it is convenient to incorporate at this point the definition of collective intelligence by Lévy [30] who identifies it “not as the fusion of individual intelligences, in a kind of indistinct magma, collective intelligence is a process of growth, differentiation and mutual reactivation of singularities. It constitutes for the collective a new mode of identification” (p. 35). Later, the same Levy assures that it is “the mutual valuation and impulse of the particularities of each one” ([31], p. 103).
Currently, management proposals based on collective intelligence (CI), have as key factors interaction, interactive learning, distributed collaboration, and the valorization of knowledge in all its dimensions [32]. All of the above leads to ensure that convergence in participation occurs in individuals through their social interactions with others. The consumer of information resignifies it from his own cognition and subjectivity and returns a construction that enters to conjugate with that of others. The result is an interaction of knowledge that structures a new form of social relationship, mediated by technological support. It allows the navigation between knowledge, because it constitutes the formalization of the “ideal of scientists, artists, entrepreneurs or network activists who want to improve the collaboration between people, who explore and make live different types of collective and distributive intelligence” ([31], p.8).
An example of this type of collective construction is crowdsourcing, a term that according to Uhlmann et al. [33] was coined by Howe [34]. Crowdsourcing refers to a random open call, to find among amateurs the proposal or solution to a certain problem, focusing on collective intelligence. Based on these concepts and on the vertiginous development of digital media, edutainment has found multiple ways of creation, reconstruction, transformation, as well as a multiplicity of meanings and interpretation edges. Today, collective or collaborative learning has become a fertile field for the approach of contextual problems and the search for their corresponding solutions.
Likewise, edutainment has begun to become a tool for the achievement not only of learning objectives but also of social transformation.
The human predisposition to play games is associated with their motivations for action. In gamification, both motivational options are evident in different forms. Yildirim [35] conducted a study with 97 participants (49 in the experimental group and 48 the control group) and found that gamification-based teaching practices have a positive impact on students’ performance, attitudes, and motivation.
One explanation for why games offer a captivating and immersive experience is the flow theory [36]. Flow is assumed to imply “a state of mind characterized by focused and heightened concentration and enjoyment of intrinsically interesting activities.” According to Mejía and Londoño [4] games enhance immersion in technological environments, prioritizing audiovisual languages and interactivity between members of a network of contacts, through the flow of information between people focused on the activities of the game. For Esnaola and Levis [37] the characteristics of flow experiences, typical of informal learning in video games, are as follows:
High levels of concentration, enjoyment, and commitment.
Immersion or loss of self-consciousness.
Focused attention.
Positive feedback.
Intrinsic motivation.
Clear ideas about the objective of the activity.
In the framework defined by Chou [38], the set of stimuli and motivations that can be included in a gamification strategy are divided into different types and have different applications depending on the type of desired outcome. Chou’s model, called Octalysis, classifies the types of motivations that can be used in edutainment categories (Figure 1) [39].
Octalysis of motivation types. Source: Coronado and Vásquez [
Coronado and Vásquez [39] propose that one of the most interesting elements of the model is that motivations can be grouped and divided into positive (white hat gamification) and negative (black hat gamification). An additional reading of the motivations provided by Octalysis is that some of them are intrinsic and others extrinsic: The right side of the octagon (empowerment, social influence, unpredictability and some elements of avoidance and meaning) contains intrinsic motivations related to creativity, expression and social relationships, while the left side (achievement, ownership, scarcity, and some elements of avoidance and meaning) includes motivations associated with calculation, logic and properties, that is, depending on external stimuli.
Generally speaking, information technologies and Internet-enabled technological devices transfer values, nuances, and ideologies to people of diverse cultures, social classes, and ages around the world. This leads to a transformation of characters, folktales, and urban legends that pass-through media filters.
The influence that unfolds over consciousness through the transfer of ideologies in the media can be of such magnitude that many institutions can instill ideas that influence thought and can come to affect human actions. These institutions can refer to large corporations, political apparatuses, states, and the larger ideologies of society. As media logic and discourse influence more experiences, our words become fully mediated [40].
The issue functions in such a way that even if consumers or audiences do not in principle share an ideology or openly object to it, exposure to it can generate future incidences. This is especially so if we are clear that the self is vacillating and manageable and is not a fixed structure. Altheide [40] warns in this regard that the social order is increasingly a mediated order, and any serious attempt to understand contemporary life cannot avoid this fact and its implications. Martín-Barbero [19] predicted this many years ago when he expressed that a mass medium is not a vessel that carries ideas from one place to another, but is itself a subjective, interpretative, and ideological form.
For its part, storytelling is not only a central element of human culture, but it replaces or replaces direct experience as a source of socialization. It has the capacity to engage or provoke a high emotional involvement in the audience and to provoke strong emotional reactions. Finally, it allows incidental learning of attitudes, beliefs, and behaviors [41].
These assumptions are based on the Socio-Cognitive Theory [42, 43]. This theory supports learning processes of new behaviors through the observation of symbolic models. However, it is proven that behaviors are not learned indiscriminately. Motivation and affect, among other factors, are involved in this process. On the other hand, it has been confirmed that the model is not enough to achieve objectives such as the promotion of prosocial behaviors [44].
Igartua [41] describes Slater & Rouner’s model, explaining that persuasive messages and edutainment content are not processed in the same way, since the goals and motivations are very different. Thus, compared to a traditional persuasive message (such as an advertisement in an information campaign), a basic motivation or processing goal is to develop correct attitudes for a particular topic. In this context, the level of involvement with the issue addressed by the ad plays a central role in understanding how the persuasive process will occur.
If the message is related to a topic relevant to the person, there will be a systematic, intense and careful processing of their arguments (central route). However, when the message focuses on a topic of low relevance, the individual will not develop such a careful or systematic processing (peripheral route; [41]). Along the same lines, the consumption of narratives exerts significant effects beyond pure entertainment, amusement and affective impact. The above is based on the human capacity to learn by observation, but without own experience.
This implies that a large part of the knowledge that a person acquires throughout his life is not obtained through direct experience, but through the stories he hears, observes, and internalizes. This approach leads to think about the substitution of lived experience and is being widely used in video games. They base their functioning on the mechanism of narrative transport, in the sense that transporting oneself to these experiences involves the subjects both cognitively and emotionally.
Therefore, Wendorf’s [45] opinion about the great help that the linking of persuasion theories can mean is relevant. Examples include Petty and Cacioppo’s [46].
Elaboration Probability Model or Ajzen and Fishbein’s [47]. Theory of Reasoned Action. Likewise, psycho-social models that explain the impact of attitudes on behavioral intention are also good theoretical references. This linkage is so promising that the application of edutainment could be extended to a distant field such as health communication [41].
Entertainment-education-based strategies include messages that are attractive to their audiences, have a strong emotional component and a clear narrative structure, and tend to engage audiences, just like any other commercial entertainment content [44, 48]. From them derives the potential for their use in health communication strategies as well as in education in general.
Slater and Rouner [44], Moyer [48], Igartua [41] and Wendorf [45] converge that motivation and the emotional component are relevant in narrative persuasion. In the opinion of Kreuter et al. [49] narrative persuasion should involve creating coherent stories that should have an identifiable structure in terms of beginning, middle, and end. It should also provide information about a scene, a character, and a particular conflict or situation, raising questions or conflicts and providing the elements that lead subjects to find or construct the solution (p. 778).
However, Moyer-Gusé [48] proposes that for this to happen there must be a kind of balance between fantasy and plausibility. Although narrative persuasion creates a
According to Green and Brock [50], transportation into a narrative world is a mental process that involves a convergence of attention, imagery, and feelings. This notion of being absorbed in the story is what distinguishes narrative processing from overtly persuasive messages [48]. Slater and Rouner’s [44] conducted work with the extended elaborative likelihood model (EELM) and found that:
Igartua and Muñiz [51] conceptualizes the identification with the characters as a mechanism through which the narrative is experienced from within, because an empathic relationship with the protagonists of the narrative is produced. According to Wendorf [45] identification in Extended Elaboration occurs primarily with a key character. It is not imitation and has four distinct dimensions: shared feelings (empathy), shared cognitions (cognition), shared goals (motivation), and absorption (transportation). Through identification with a key character, individuals can enact responses and choices to situations from a position of suspended ideology. Identification with characters is associated with greater cognitive elaboration and developing a reflective process of higher quality or complexity during the viewing of a dramatic feature film among other content [51].
Subjects, identifying with the character, respond from the role to their role, suspending their own thoughts. Transportation is the complete absorption by the narrative of an audience member and allows individuals to temporarily lose themselves. Green and Brock [50] also assume it as a convergent process, but of all mental systems and capacities focus on the events that occur in the narratives.
Wendorf [45] proposes that those involved in narrative persuasion are better able to understand the other’s position through distancing themselves. In addition to temporarily losing access to reality, the possibilities for introspection in the choice of roles and the lived experience of those assigned or chosen are increased. According to Wendorf [45], equally important is the homophily or belief that one possesses information, emotions, or cognitions with the character. This experience places subjects in a position of greater susceptibility to attitude changes presented in persuasive narrative content [44].
Other essential concepts are parasocial interaction, originally coined by Horton and Wohl in [52] with the aim of referring to the chimera of reciprocal interaction that audience members felt toward media figures, especially, television at that time. Through such interactions viewers have the feeling that they know the characters or develop the same vicarious type of friendship relationships. This leads them to care about the characters when they go through difficult/compromising situations or to rejoice and express positive emotions at their successes [53].
There are studies that evaluate the role played by parasocial interaction and narrative participation in attitude change. There are also evaluations on the probability of viewer elaboration, attitude change and the probability of behavioral change, among other topics [54, 55, 56].
Another intervening factor is the concept of perceived self-efficacy, defined as confidence in one’s own ability to achieve the intended outcomes in a given situation [57, 58]. Self-efficacy is considered one of the most important predictors of behavior change in society. In fact, empirical studies explain it as a moderating factor. Van’t Riet et al. [59] have also suggested the positive role of self-efficacy in persuasion but including a protective factor (Motivation Theory (PMT) and the Extended Parallel Process Model (EPPM). For Rogers [60], individuals with higher self-efficacy are more likely to accept persuasive narratives than those with lower self-efficacy, who may react defensively, either by ignoring the message or rationalizing negatively.
Worchel and Brehm [61] and Brehm and Brehm [62] propose from this defensive presupposition the psychological reactance theory (PRT). It argues that, when perceived freedom is removed or the individual feels threatened by external factors, he or she will be motivated to restore that freedom. The authors explained that this restoration of freedom refers to restoring individuals’ sense of autonomy and self-determination. Subsequent studies have indicated that individuals of higher self-efficacy tend to be more deeply engaged in processing because they are more confident in the recommended behavior and are more motivated to evaluate the advantages and disadvantages of carrying out the recommended behavior.
The structural elements of persuasive storytelling described in the previous paragraphs configure a framework reference for social transformation processes. Therefore, it becomes another framework, this time of converging vectors. Those come together in the commitment to the construction of innovative educational perspectives. In turn, this construction could be display from games platforms, either from gamification used as a learning tool without narrative theoretical foundations or from serious games with the mediation of communication as a fundamental element.
The incorporation of digital games in educational institutions facilitates new ways of accessing, generating, and transmitting information and knowledge. This allows to make flexible, transform, extend and, ultimately, to seek new perspectives of the educational act. Specifically, the effective linking of digital games makes the temporal and spatial contexts more flexible and, along with the interaction and reception of information, among other aspects.
This incorporation also delocalizes knowledge and generates interaction with different types of codes and symbolic systems. At the same time, it leads to the choice of the formative itinerary and of strategies and techniques for training and technological convergence. Likewise, it favors access to information and its different sources and, of course, flexibility in terms of the roles of the teacher and his or her figure.
The above conclusion is consistent with Eftimova et al. [63]:
The review of the different ways of approaching games makes it possible to distinguish between games for learning and serious games. The main differences between them are circumscribed in the management of motivation and fun in the games. Learning games are based on motivation and fun to facilitate educational processes. Serious games, on the other hand, require a particular theoretical foundation on which their structure is built and do not depend on fun, since motivation is handled from theories of persuasion.
Regarding its effectiveness, authors such as Bolyle and Connolly [64], Connolly et al. [12] stated that, despite the increased popularity of game-based learning, there is a lack of empirical evidence to support its validity. However, current scientific research has shown otherwise. The theoretical review found that there are many papers with game platforms that demonstrate the effectiveness of games. Caserman et al. [65] investigated the effectiveness of games based on the following criteria:
Focus on the characterizing goal, clear goals, indispensability of the characterizing goal, correctness of the domain expert content, appropriate feedback on progress, appropriate rewards, proof of effectiveness & sustainable effects, awards, and ratings.
Caserman’s results showed that:
According to the above, the discussion does not focus on the effectiveness of games to facilitate learning (gamification) and social change (serious games); what is relevant in this regard is their design, set-up, and structure to achieve their intended objectives, as described by several authors [5, 6, 7, 8, 66, 67].
There are many challenges for researchers in the field, including the application of effective evaluation instruments and the rigorous analysis of the results of the application of games. In this sense, it is of great relevance that game design should be based on scientific research, so that valid and reliable results can be obtained. However, it is important to note that to the extent that serious games and gamification allow participants to learn by doing, they are in line with technological advances and in this sense contribute innovative aspects to education.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
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\\n\\nOA Publishing Fees
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
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\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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Existing bacterial detection methods rely on conventional culture or microscopic techniques and molecular methods that often time consuming, laborious and expensive, or need trained users. In recent years, biosensor remained an interesting topic for bacterial detection and many biosensors involving different bio-probes have been reported. Compared to antibodies, nucleic acids and enzymes etc., based biosensors, bacteriophages can be cheaply produced and are relatively much stable to elevated temperature, extreme pH, and diverse ionic strength. Therefore, there is an urgent need for phage-based biosensor for bacterial pathogen detection. Furthermore, bearing high affinity and specificity, bacteriophages are perfect bio-recognition probes in biosensor development for bacterial detection. In this regard, active and oriented phages immobilization is the key step toward phage-based biosensor development. This chapter compares different bacterial detection techniques, and introduces the basic of biosensor and different bio-probes involved in biosensor development. Further we highlight the involvement and importance of phages in biosensor and finally we briefed different phage immobilization approaches used in development of phage-based biosensors.",book:{id:"7007",slug:"biosensors-for-environmental-monitoring",title:"Biosensors for Environmental Monitoring",fullTitle:"Biosensors for Environmental Monitoring"},signatures:"Umer Farooq, Qiaoli Yang, Muhammad Wajid Ullah and Shenqi Wang",authors:null},{id:"69216",title:"Challenges and Applications of Impedance-Based Biosensors in Water Analysis",slug:"challenges-and-applications-of-impedance-based-biosensors-in-water-analysis",totalDownloads:1184,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Monitoring of the environment is a global priority due to the close connection between the environmental pollution and human health. Many analytical techniques using various methods have been developed to detect and monitor the levels of pollutants (pesticides, toxins, bacteria, drug residues, etc.) in natural water bodies. The latest trend in modern analysis is to measure pollutants in real-time in the field. For this purpose, biosensors have been employed as cost-effective and fast analytical techniques. Among biosensors, impedance biosensors have significant potential for use as simple and portable devices. These sensors involve application of a small amplitude AC voltage to the sensor electrode and measurement of the in-/out-of-phase current response as a function of frequency integrated with some biorecognition element on the sensing electrodes that can bind to the target, modifying the sensor electrical parameters. However, there are some drawbacks concerning their selectivity, stability, and reproducibility. The aim of this paper is to give a critical overview of literature published during the last decade based on the development issues of impedimetric biosensors and their applicability in water analysis.",book:{id:"7007",slug:"biosensors-for-environmental-monitoring",title:"Biosensors for Environmental Monitoring",fullTitle:"Biosensors for Environmental Monitoring"},signatures:"Kairi Kivirand, Mart Min and Toonika Rinken",authors:[{id:"24687",title:"Dr.",name:"Toonika",middleName:null,surname:"Rinken",slug:"toonika-rinken",fullName:"Toonika Rinken"},{id:"62780",title:"Prof.",name:"Mart",middleName:null,surname:"Min",slug:"mart-min",fullName:"Mart Min"},{id:"174179",title:"Dr.",name:"Kairi",middleName:null,surname:"Kivirand",slug:"kairi-kivirand",fullName:"Kairi Kivirand"}]},{id:"63693",title:"The Modeling, Design, Fabrication, and Application of Biosensor Based on Electric Cell-Substrate Impedance Sensing (ECIS) Technique in Environmental Monitoring",slug:"the-modeling-design-fabrication-and-application-of-biosensor-based-on-electric-cell-substrate-impeda",totalDownloads:1094,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"In this research, the modeling, design, fabrication, and application of ECIS sensors in environmental monitoring are studied. The ECIS sensors are able to qualify the water toxicity through measuring the cell impedance. A novel mathematical model is proposed to analyze the distribution of electric potential and current of ECIS. This mathematical model is validated by experimental data and can be used to optimize the dimension of ECIS electrodes in order to satisfy environmental monitors. The detection sensitivity of ECIS sensors is analyzed by the mathematical model and experimental data. The simulated and experimental results show that ECIS sensors with smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio, which is more suitable in measuring the cell morphology change influenced by environments. Several ECIS sensors are used to detect the toxicant including, phenol, ammonia, nicotine, and aldicarb, and the decreasing cell impedance indicates the toxic effect. The gradient of measured impedance qualitatively indicates the concentration of toxicants in water.",book:{id:"7007",slug:"biosensors-for-environmental-monitoring",title:"Biosensors for Environmental Monitoring",fullTitle:"Biosensors for Environmental Monitoring"},signatures:"Xudong Zhang, William Wang and Sunghoon Jang",authors:null},{id:"65873",title:"Electrochemical Biosensors Containing Pure Enzymes or Crude Extracts as Enzyme Sources for Pesticides and Phenolic Compounds with Pharmacological Property Detection and Quantification",slug:"electrochemical-biosensors-containing-pure-enzymes-or-crude-extracts-as-enzyme-sources-for-pesticide",totalDownloads:1082,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Biosensors are chemical sensors in which the recognition system is based on a biochemical mechanism. They perform the specific component detection in a sample through an appropriate analytical signal. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"11",type:"subseries",title:"Cell Physiology",keywords:"Neurodevelopment and Neurodevelopmental Disease, Free Radicals, Tumor Metastasis, Antioxidants, Essential Fatty Acids, Melatonin, Lipid Peroxidation Products and Aging Physiology",scope:"
\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/76617",hash:"",query:{},params:{id:"76617"},fullPath:"/chapters/76617",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()