DML simulation parameters.
\r\n\tHowever, despite the positive outlook and trends in routing protocol design, there are still several open or unresolved challenges that researchers are still grappling with. Providing adequate responses to those challenges is essential for next-generation networks in order to maintain its reputation and sustain its preponderance in cyber and physical security. Some of the challenges include, but are not limited to, the following:
\r\n\t• Robustness and reliability of routing protocol
\r\n\t• Reduced dependencies on heterogeneous networks
\r\n\t• Security of routing protocols
\r\n\t• Dynamic Adhoc routing Protocols
\r\n\t• Routing in 5G Networks
\r\n\t• Routing IoT enabled networks
\r\n\t• Scalable and dependable routing system architectures
\r\n\t• QoS and QoE Models and Routing Architectures
\r\n\t• Context-Aware Services and Models
\r\n\t• Routing Mobile Edge Computing
\r\n\tThe goal of the book is to present the state of the art in routing protocol and report on new approaches, methods, findings, and technologies developed or being developed by the research community and the industry to address the aforementioned challenges.
\r\n\tThe book will focus on introducing fundamental principles and concepts of key enabling technologies for routing protocol applied for next-generation networks, disseminate recent research and development efforts in this fascinating area, investigate related trends and challenges, and present case studies and examples.
\r\n\tThe book also investigates the advances and future in research and development in Routing Protocols in the context of new generation communication networks.
In the era of explosive demand for bandwidth and complex broadband transmission attributed to the fifth-generation (5G) and beyond, strategic positioning of fiber optics communications is imperative considering its huge advantages in terms of high-speed transmission, simplified design and low cost implementation [1].
Fiber Optics communication, which is carried out through photon, has been a promising approach that can conveniently guarantee the requirements of high data transmission. However, the existing technologies will require complete overhauling, upgrading, or redesigning for effective results [2]. Unarguably the 5th and 6th generations of wireless networks cannot sufficiently guarantee their expected output in terms of speed, latency and spectral efficiency without improved channel architectures.
Therefore, there is an urgent need to further optimize optical properties to meet the current and future demands for high-speed data communications [3]. Fiber optics on its own with peak-to-peak throughput of 100 Gb/s is unique among other communication channels, and as of today, its capacity in terms of speed and convenience of communication has not been fully utilized [1].
Similarly, PIC as an enabler for optical communications presents a promising approach for conveniences of communications in terms of low footprint, low cost implementation, and very high speed [2, 4]. Therefore, increasing data rate and mobility in the evolving technologies require an increase of data traveling in the networks, introducing new requirements (e.g., speed and latency) for the components, e.g., PIC building blocks (BB). Although, PIC components under terahertz speed is a promising technique to guarantee the requirements of future networks, the maturation of the integrated photonics is still ongoing.
Furthermore, to strengthen the position of fiber optical communications for the emergence of hyperscale future transmission such as hyperscale data centers (HDCs) and to continually improve the amount of data transmission over optical networks through modulation and multiplexing approaches, this chapter will address a detailed description of DML and EML modulation schemes, and improved hybrid approaches, a valuable solution to attain the overcoming requirements of high-speed signal transmissions.
Conventional approaches are carried out through direct modulation laser (DML) and external modulation laser (EML) respectively which cannot guarantee the demands of future networks due to their respective limitations [2, 5, 6]. Although DML is simple in design and can generate high power budget when properly optimized but, the signal is degraded due to high CD, induced adiabatic chirp, phase noise, and low extinction ratio (ER). Consequently, these limit DML transmissions to a short distance of about 10 km and its inability to cope with high bit-rate transmissions [5, 6, 7].
EML on the order hand outperforms DML with reduced chirp and better reach. Nevertheless, the signal is also limited due to size, low optical power and high driving voltage among others [2, 8, 9]. Hence, a hybrid combination and optimization of these modulation processes can be seen as a powerful approach.
With the HM method, high bit-rate signals can be generated in a simplified way with a low footprint, low energy consumption and less complexity in meeting the demand for future networks [2].
This chapter provides a detailed study of the development and optimization of a simplified optical transceiver for high data rate 5G optical transmission, in order to manage future competitive markets necessities in its migration to 100G and 400G Ethernet, by replacing the single-mode 10G-SFP+ used for 4G networks. Moreover, the access and aggregation layers patterned with Dense Wavelength Division Multiplexing (DWDM) transceivers having bit-rate as high as 400G designed for metro access, metro convergence and core layer access networks, are also studied.
With HM approach, simplified and high bit-rate intensity modulated signals can be generated without electrical pulse shaping, digital to analog conversion (DAC), and digital signal processing (DSP) compensation [2].
The remaining part of this chapter is arranged as follows: in section 2, details signal modulation approach for PIC is discussed follow by section 3 where we presented the novel HM approach and the results of our simulations. We draw the conclusion in section 4.
The crucial function of modulators in optical communications is the conversion of the electrical information input signal into its corresponding optical domain which is placed on the optical signal as a carrier before being launched into an optical communications channel. This process is carried out in the optical transmitter, where an optical signal from an optical source such as a semiconductor laser or light-emitting diode (LED) is either directly or externally modulated. Optical signal has three major properties which are amplitude, frequency and phase. However, the message electrical signal is biased to manipulate any of these optical properties so that information can be sent along optical channels [2, 9].
Modulation of the optical carrier properties mentioned above could be done directly or externally [5]. Direct modulation is achieved using a DML [8], while the external modulation, which is equally referred to as external modulation laser (EML), can be either through electro-refractive using Mach Zehnder Interferometer (MZI) [9] or electro-absorption using an electro-absorption modulator (EAM) [7, 9].
The simplicity of design and cost [9, 10] make DML a preferred choice, nonetheless several constraints make it undesirable for high bitrate and long-distance transmission [7]. These constraints include low bandwidth, low efficiency, CD caused by induced chirp which imposes signal phase noise, refractive index change of the active layer by carrier density modulation and relatively low ER [5, 6]. DML induced chirp can be transient or adiabatic. Chirp due to transient gives a nonlinear gain which occurs during the bit transitions, while the adiabatic chirp is the spontaneous emission that occurs in the laser, which is responsible for the blue-shifting of bit 1 relative to bit 0 [11]. As a result, the increase of bit-rate in DML causes the signal to suffer a very pronounced pulse broadening due to CD [6], mainly when the bit-rate is increased beyond 10 Gb/s [12]. The chirp in DML is mainly influenced by the linewidth enhancement factor, which is also known as Henry factor limiting within 2 and 8 for DFB laser, and consequently, the signal of 10 Gb/s transmission could not go beyond 10 km [13].
On the other hand, external modulation approaches can achieve high ER, high data-rate, and lower modulation distortion. Unfortunately, this comes with additional system complexity and cost compared to direct modulation [14]. For the external modulation, EAM offers lower cost and size combining with a considerably higher speed when compared to MZI [9, 15]. EAM can achieve better speed with low CD as a result of its zero or negative chirp [6] with the inherent advantage of low driving voltage and the possibility of monolithic integration with a DFB laser on a single waveguide, which reduces channel insertion loss (IL) [9, 16, 17]. Furthermore, EAM optical modulation does not affect the laser properties unlike DML [7] and its low CD can achieve improved speed (25–40 Gb/s) and longer distance (10–40 km) [7, 9]. Additional details regarding the two technologies are provided in the subsections 2.1 and 2.2. Presented results were attained by VPIphotonics® transmission simulations.
In this approach, an electrical signal is directly injected into the lasing cavity in an attempt to manipulate the stimulated emission present in the laser cavity. By this, a high-frequency electromagnetic signal with information could be sent via optical channel after modulation [9, 14]. Figure 1 gives an illustration of how the DML approach can be achieved and its chirp effects.
DML showing electrical signals without chirp before modulation and optical signal after modulation with chirping effect.
Practically, semiconductor lasers such as distributed feedback laser (DFB), constricted-mesa lasers and Fabry-Perot (FP) lasers are the major lasers used for DML purposes. It is important to note that DML is simple and cost efficient but can only be applied with low bit-rate and short-reach as a result of chirp due to spectral broadening associated with the biasing current during modulation. This is due to accompanying phase modulation (PM) to the desired intensity modulation (IM) during this process [18]. The level of the chirping imposed on the modulated pulse largely depends on the driving condition (Ibias and modulation current (ΔI)) and the laser type.
The chirp associated with DML can be subdivided into transient and adiabatic chirp as depicted in Figure 2. The presence of chirp in the modulated pulse leads to high CD and invariably inter-symbol-interference (ISI) which adversely weakens the reach and effects of DML transmission.
DML power time domain response showing transient and adiabatic chirp.
According to [19], transient chirp is associated with the relatively small frequency difference between the steady-state of signal pulse levels of ones and zeros. This frequency difference leads to ringing and significantly obvious overshooting of optical output power and frequency deviations.
Adiabatic chirp at the same time can be described with the damping oscillations and large frequency differences between pulse ones and zeros.
Compensating the chirp and CD in DML comes with its own cost and complexity. Some of these approaches are the use of dispersion compensation fiber (DCF), electrical signal compensations through decision feedback equalizer (DFE), feed-forward equalizer (FFE), continuous-time linear equalizer (CTLE), digital signal processing (DSP), electrical pulse shaping and finally, optical CD compensation through optical spectrum reshape (OSR) [20]. This OSR method is better detailed in the subsection 3.3.
Nevertheless, progressive works to reduce the effect of chirp on DML show improved results. For instance, in [21], an InGaA1As/InGaA1As multi-quantum well (MQW)-DML was grown on an n-doped InP substrate by shortening the laser cavity length to less than 150 μm via positioning of a passive waveguide in the front of the DFB laser. The DML was operated at 45 mA driving current with 43 Gb/s bit-rate, the optical signal obtained after 40 km presents a clear eye signal at 25 °C which shows an improved bit-rate possibility higher than 10 Gb/s over DML.
Similarly, the research work in [22] also presents a 40 Gb/s DML optical signal that used passive feedback laser (PFL) realized around 1300 nm and 1550 nm wavelength region. In this work, DFB and integrated passive feedback section (IPF) were combined enabling the suppression and control of the phase feedback field with the modulation performance of the stationary operating laser.
Other works in [23, 24, 25] also present similar improvements in the design of DML with higher bit-rate and improved fast speed transmission. The authors in [23] used InP-on-Si to achieve 45 Gb/s and 25 GHz 3-dB modulation bandwidth at a relaxation oscillation frequency of 10 GHz using NRZ encoder. The fabricated laser has two sections of around 250 μm each with an active region on InGaAsP separate confinement hetero-structure (SCH). A clear eye diagram after a 2 km transmission of 45 Gb/s was obtained with BER lower than 7% Hard Decision (HD) forward error correction (FEC) and received optical power (ROP) around −7 dBm.
To further investigate the behavior of DML, we carried out a simulation study of a rate equation model of a semiconductor DFB laser. In order to reduce the effect of the unwanted transient chirp on the modulated signal, it is highly advised to bias the laser far away from the current threshold [9, 26], allowing to obtain high optical output power after modulation. Although, this is a trade-off with the optical signal ER. In our case, the laser current threshold is obtained around 10 mA and as we biased away from this point, the output optical signal increases with reduced transient chirp while the signal ER reduces.
The block diagram for an intensity DML is presented in Figure 3 and the DML parameters used are summarized in Table 1.
Block diagram of a DML characterization bench.
Simulation Parameters | Value |
---|---|
BitRate | 10 Gb/s |
Wavelength | 1.57 μm |
Laser Bias Current | 90 mA |
Laser Confinement Factor | 0.5 |
Henry Linewidth Enhancement Factor | 3.0 |
DML simulation parameters.
A non-return to zero (NRZ) electrical modulation scheme is supplied with pseudorandom binary sequence through modified Wichman-Hill generator with length M bits = TimeWindow*Bit-Rate, which is applied on the DFB laser while biasing at given current in order to modulate its amplitude [27]. The transmitted optical pulse after modulation for the giving rate equation laser is expressed by Eq. (1).
Where
The received optical power (ROP) and ER at different laser modulation current and bias are depicted in Figure 4. In section 3, this obtained result will be optimized through our simplified HM approach.
ER and ROP variation against DML biasing current.
EML signal generation as an alternative to DML can eliminate significantly the frequency chirp effect associated with direct modulation scheme [9]. The procedure requires a continuous wave laser (CW-laser) providing constant optical signal into the external modulator and an external electrical signal is applied to manipulate any of the desired properties (intensity, phase and frequency) of the light. A standard EML operation mode is depicted in Figure 5, comprising the CW laser, external modulator and the external electrical driving voltage.
Block diagram of an external modulation laser.
As mentioned in the introduction section, two main approaches of external optical modulation are: i) the electro-refractive (LiNBO3 MZM); and ii) the electro- absorption (EAM) [13]. We shall briefly discuss design approaches and the mode of operations of these devices.
The overall behavior of the MZM as presented in Figure 6 largely depends on its design and configuration, e.g., based on the lithium niobate crystal. A good design MZM has high ER with low chirp, which requires high driving voltage. The amount of driving voltage will then result in a large dependence of device’s efficiency [22]. This voltage effect can be translated by MZM power transfer function in Eq. (2).
Typical mode of operation of a MZM modulation scheme.
Where
EAM is considered an attractive modulation approach for fast-speed optical communications due to its low driving voltage, high bandwidth, high modulation efficiency and the possibility of monolithic integration with other semiconductor devices [28, 29]. EAM is an intensity modulator that changes the absorption properties of the carrier optical signal through the application of voltage V(t) around the band edge of the waveguides [9, 30].
Unlike MZM that modulates both intensity and phase of the carrier signal, EAM as an intensity modulator shows additional advantages, e.g., its linearity in the amplitude multilevel modulation, which offers lower total harmonic distortion when comparing to the MZM [9]. Nevertheless, MZM can achieve higher ER, an EAM with similar ER would imply increase size and therefore increase IL [9, 14].
The driving of EAM is attained with negative bias voltage to guarantee an efficient light absorption of the modulator [9]. To work in the linear region of the EAM we choose the driving voltage range [-4 V to −1.5 V], see Figure 7.
EAM ROP vs. V curve. Linear region can be spotted between −4 V and − 1.5 V (laser power = 10 dBm).
Biasing the modulator must be kept within the linear region to prevent signal distortion [30]. However, voltage biasing here presents a trade-off between modulation efficiency (eye-opening) and the EAM linearity limit. With higher amplitude, EAM linear region can be extended but this will sacrifice signal efficiency with the distorted eye. In our case for 50 μm long EAM, the bias voltage is fixed at −3 V with a linear region between −4 V and − 1.5 V and the voltage swing of 1.5 V.
In the design of EAM, two major approaches are employed: i) a bulk process through Franz-Keldysh Effect, and ii) a Multi-Quantum Well (MQW) through Quantum Confined Stack Effect (QCSE) [9, 31]. Investigations show that MQW-EAM is preferred over Bulk-EAM due to its large absorption coefficient [16, 28, 31, 32, 33, 34], leading to higher ER [35].
Considering EAM parameters from published studies [2, 32, 35, 36, 37, 38], we simulated the modulation amplitude transfer function T(t). EAM inherent properties used as a figure of merit for a wavelength of 1.57 μm and EAM of 200 μm in length, were 0.055 dB of IL and 0.115 dB of ER per 1 μm length of EAM. Therefore, an increase of EAM ER (and thus EAM length) is given at the expense of an IL increase. This is a major setback for the use of EAM in EML modulation schemes.
Furthermore, we simulated T(t) parameters interpolation to mimic the behavior of 200 μm EAM and obtained T(t) against V(t) for different EAM length at 1.57 μm optical wavelength based on the properties of EAM length stated above.
The obtained results of EAM length versus its IL and ER are provided in Figure 8.
EAM ER and IL versus EAM lengths. For the ER values, the EAM was biased at −4 V and modulated at 0 V.
The compromise between EAM IL and ER, by changing EAM size, allow us to reach the necessary requirements of our optical transmitter, essential information to model our hybrid transmitter as presented in the section 3.
Operation of EML through the EAM intensity modulator stated here can be expressed by Eq. (3).
Where
The modulating voltage v(t) and the bias voltage Vo which are used for electrical driving of the modulator are related to T(t) according to Eqs. (5) and (6).
An obvious treat on conventional communication procedures with the current BB which leads to high system impairment and overloads has led scientific community to think further on the prospect of hybrid combination of processes and components [39]. This approach can be implemented monolithically in an InP-based platform, allowing higher spectral efficiency and the ability to generate high bit-rate signals [40].
Different limitation can be addressed for DML and EML modulation schemes. For instance, DML can only be used for relatively lower speed ≤25 Gb/s and cannot be transmitted beyond 10 km for data-center interconnect (DCI) and passive optical networks (PON) systems [7]. On the other hand, external modulation through EAM is limited by high IL values to address requirements of high ER [2]. Combining the advantages versus limitations of these two modulation schemes can result in improvements of the overall signal generation for DCI and PON systems, by mitigating the problems of transmission loss and group velocity dispersion (GVD).
Past works on optimization of transmission efficiency are associated with costly and complex system designs [22, 23, 24, 25]. Hence, a procedure to reduce or eliminate these limiting factors are vital to the success of 5G deployment. Since PIC is still undergoing its maturity stage, its best design, functionality and efficiency are still under research. Several approaches used for impairment compensation can be optimized through hybrid combinations of BBs. In this work, we have conducted extensive studies and simulations of procedures for signal generations through direct and external modulation schemes. DML limitations have been discussed in section 2.1. External modulation on the other hand presents an attractive alternative to DML although, nevertheless with the constrain of high IL, which requires a laser with enough output power to overcome this loss.
Thus, HM concept appears as a useful approach, by exploring the advantages of both direct and external modulation approaches and components functionalities to produce a full integrated system. One major obstacle in the proposed hybrid combination is the presence of short noise dominated by photons from the DML due to spontaneous emission and the electron–hole recombination which significantly reduces the signal-to-noise ratio (SNR) of the hybrid transmitter [9]. We have provided a measure to reduce this noise and also reduce the transient chirp in the DML pulse through optical signal reshaper (OSR) approach which will be presented later in this section.
Modulated optical signal from DML is launched into the optical signal input of the characterized EAM under study in order to re-modulate the optical signal for intensity signal generation. The T(t) earlier described in Eq. (6) that depends on the driving bias voltage and length of the modulator is loaded as a data file through VPIphotonics transmission maker optical simulator to control the EAM [41]. Therefore, for HM-model, Eq. (3) can be rewritten as presented in Eq. (7)
From the Eq. (3) We have replaced the
The corresponding schematic is presented in Figure 9. It consists of PRBS and NRZ electrical signal encoder used for driving DML. In the case of HM, the electrical signal is split into two to drive both DML and EAM. the EAM amplitude is configured with reverse bias voltage of −3 V which fall within the EAM linear region.
Simulation setup for HM approach.
The obtained signal
The measured ER and ROP by changing the length of EAM and modulation current at fixed bias (90 mA) current of DML are presented in Figure 10 and Figure 11 respectively. The DML ROP and ER before launching the optical signal for intensity modulation are also highlighted on the graphs.
ER at hybrid transmitter’s output for different EAM-length against DML modulation current: EAM bias, V0 = -3 V, EAM voltage swing, v(t) = 2 V, DML Bias = 90 mA.
ROP at hybrid transmitter’s output for different EAM-length against DML modulation current: EAM bias, V0 = -3 V, EAM voltage swing, v(t) = 2 V, DML Bias = 90 mA.
We further launched the optical signal at different EAM lengths tested into optical distribution networks (ODN) ranging from 5–40 km in order to study the behavior of the signals and responses to dispersion and non-linearity in the fiber, see Figure 12. With increased EAM length, the signals present an improved error rate from the 5 km starting point up to 20 km which is attributed to high ER.
BER and ROP versus fiber length for optical signals stemming from EAM with different lengths.
However, since higher ER also contributes to higher IL coupled with the attenuation in the fiber, the signal with lower EAM length (EAM = 5 μm) gives a better error rate than when EAM length is 200 μm as we continue to increase the length of the fiber as presented in Figure 12. At 40 km all the signals from different EAM lengths tested were received at an error rate less than 10−3.
Short reach fiber optic communication such as PON, short-reach video on demand (VoD) and DCI have recently advanced the demand for bandwidth [42]. This demands more efficient and advanced high spectral modulation format to replace the conventional NRZ line code [43] in order to guarantee high data rate beyond 50 Gb/s per channel [41, 44]. IEEE 802.3 group quad small form-factor pluggable (QSFP) 400 Gb/s specifications for short-reach data center communication systems have been studied progressively. Better data rate usage such as 56 Gb/s per channel can help to reduce system design complexity and cost [44, 45, 46]. Studies show that access, aggregation and core networks bandwidth demand in 5G can be adequately guaranteed with 400 Gb/s PAM-4 signal generations with either 56 Gb/s 8-channel or 100 Gb/s 4-channel networks [47, 48]. With this provision, some key requirements of 5G networks such as low cost, high performance and high bandwidth can be adequately guaranteed.
PAM-4 is a multi-order modulation approach which presents a bit-rate twice of the NRZ signal line code under the same baud-rate using four levels for signal transmission with two bits of logical information per each clock period [48]. However, PAM-4 presents a high degree of complexity in the signal generation, coupled with its sensitivity to amplitude noise which leads to a high signal to noise ratio (SNR) [45]. This is because PAM-4 signal have four levels with three eyes, which implies that, its signal is generated with an amplitude (A) of A/3 compared to NRZ that has a SNR = A. With this deficiency, PAM-4 signal is at least three times more sensitive to amplitude noise than NRZ.
To generate a PAM-4 signal for optical communication however, some complex system designs are used. In [48], physical coding sub-layer (PCS) is used to support forward error correction (FEC) at both transmitter and receiver for signal coding/encoding, scrambling/descrambling, signal alignment, signal sorting and control. Another important signal efficiency enhancement procedure is the use of electrical digital to analog converter (DAC) at the transmitter and receiver [43]. DAC usage also comes with some degree of nonlinearity and power greediness that can limit their usefulness for multi-level modulation scheme like PAM-4 in a cost effective system [48]. If nonlinearity of signal is not eliminated or reduced, it usually leads to signal distortion, which will require additional pre-distortion management procedures such as static pre-distortion (SPD) and dynamic pre-distortion (DPD) for non-linearity compensation [49]. The digital signal processing (DSP) for distortion and dispersion compensation as presented in [49, 50] to eliminate power fading high-frequency signals have further complexity in conventional PAM-4 signal generations that contradict 5G requirements for low cost signal generation approaches.
In [51], feedforward equalizer (FFE) and decision feedback equalizer (DFE) are employed at both transmitter and receiver to cancel the multi-level signal ISI and this is accomplished with system complexity and cost. To mitigate some of the complexity in PAM-4 signal generations in order to meet the demand for low cost, energy-efficient and low footprint demand for 5G networks, optical DAC PAM-4 signal generation was used in [44] with high tolerance to modulation nonlinearity. In terms of distance covered also, modulation through DML with high bit-rate signal shows several limitations due to the high chirp associated with its signal coupled with the lagging of lower PAM-4 eye while transmitting with high bit-rate and high modulation current [46]. Although, DML approach shows the simplest and most cost-effective measures but highly limited to low bit-rate and shot reach.
However, in our approach to eliminate these aforementioned limitations in PAM- 4 signal generation, unlike the conventional signal generation with EAM where electrical PAM-4 signal is employed to generate optical PAM-4 signal, the concept of HM approaches for NRZ signal generation we presented in [2] is further employed to generate optical PAM-4 signal. The approach is optimized in a simplified way to generate the signal for short reach transmissions without signaling, nonlinearity and CD compensation. The complete simulation setup is presented in Figure 13. We conducted further optimization of our HM model to design 28-GBaud PAM-4 signal and in fact, the same approach was tailored towards generating a simplified 20-GBaud PAM-8 signal eliminating the conventional complexity of electrical signal coding and pulse shaping.
Schematic of the simplified multilevel (PAM-N) signal generation approach through HM model.
Both transmitters show an optical launch power of more than 4 dBm with 5 dB and 7.5 dB ER respectively. At the receiver, the multilevel signals are decoded through direct detection approach with a PIN photodetector. The eye diagrams of both PAM-4 and PAM-8 signals generated with this approach are presented in Figure 14. The results of transmission over 8 km of both the 28 GBaud PAM-4 and 20 GBaud PAM-8 obtained through offline digital signal processing using Gaussian approximation give error analysis below 10−3.
Eye diagram of 28 GBaud PAM-4 and 20 GBaud PAM-8 signals generated with simplified HM approach. Here the PAM-4 signal has an ER = 4.5 dB and PAM-8 signal with ER = 7.5 dB, both signals having ROP higher than 4 dBm.
The major effect of DML is the associated phase modulation to the intensity modulation, which results in CD and then ISI. In the HM model, some degree of chirp is still present in the modulated signal, which introduces limitations. With the concept of chirp managed lasers (CML) through optical signal reshaper (OSR), the transient chip from the DML can be reduced. More also, since our DML optimization earlier presented is tailored towards improving the optical signal power output and reducing the transient chirp by biasing away from the threshold. This reduces the signal ER. With the concept of CML, the ER of the DML optical signal can be optimized as well as the transient chirp. An update to the schematic in Figure 9 is presented in Figure 15 including a Gaussian optical filter optimized as an OSR.
Hybrid simulation approach + CML-OSR.
The entire CML-OSR approach can be studied in [52, 53, 54, 55]. The concept of CML decouples optical signal power and chirp of the DML signal [53], which is achieved by configuring the Gaussian filter as a band-pass filter (BPF) having a central frequency higher than the frequency of the carrier signal. This enables the filter to undergo signal edge filtering by suppressing the 1-bit while attenuating the 0-bit of the distorted NRZ optical pulse from DML. The filter is configured with a 3 dB bandwidth lower than the bandwidth of the carrier signal which distorts the signal but at the same time cut-off most of the high-frequency noises associated with the optical signal pulse. Hence, the bandwidth is highly significant to the overall performance of the OSR but care must be taken in using this approach for hybrid multilevel signal generations (e.g., PAM-4 and PAM-8) if the OSR bandwidth is further reduced or if the filter central frequency is further increased. The behavior of this approach is shown in Figure 16 while the simulation parameter is also presented in Table 2. Applying this model on our generated HM optical signal improves the signal ER which further improves the overall performance of the final optical signals from the hybrid transmitter. More also, the filter significantly reduced the transient chirp associated with the DML signal. We applied this concept to both the binary and multilevel signals generated in our earlier sections and significant improvement in terms of reach was observed. With OSR, we were able to transmit a binary 40 Gb/s HM signal beyond 40 km and both 28 GBaud PAM-4 and 20 GBaud PAM-8 signals respectively up to 10 km.
CML-OSR showing DML signals before and after OSR filtering.
Filter Parameters | Value |
---|---|
Filter Type | BandPass |
Transfer Function | Gaussian |
Filter Center Frequency | 190.99e12 Hz |
Filter Bandwidth | 60 GHz |
Gaussian Order | 4 |
CML-OSR simulation parameters.
We have proposed and demonstrated the concept of simplified high bit-rate signal generation with a HM approach in this chapter. The current 5G and the beyond technologies specifically target such a model with less complexity but unprecedented spectral efficiency in order to reduce the capital expenditure (CAPEX) and operation expenditure (OPEX) of signal transmission and at the same time guarantee the speed requirements of the application over optical communication networks. Through simulations, we have demonstrated and shown that there is a clear path to achieve 5G backhauling without the need for CD pre and post compensation for high bitrate signal generation in short and medium reach networks. We also showed that proper optimization can improve signal launch power and eliminate the necessity of expensive optical power amplifier for high bitrate signal transmission. HM clearly simplified signal generations as we have presented in this chapter with right combination of process and components. Further research is ongoing to implement this model on a PIC so that we can perform a real-life laboratory test of the chip and investigate other areas of optimizations.
This work is supported by the project Virtual Fiber Box, with reference number POCI-01-0247- FEDER-033910, funded by the European Regional Development Fund (FEDER), through the Operational Program Competitiveness and Internationalization (COMPETE 2020), of Portugal 2020 framework (P2020).
The term ‘Probiotics’ conventionally refers to the substances produced by microorganisms that stimulated the growth of others. With the advancement of knowledge in the subject, the use of the term was later extended to describe the tissue extracts that stimulated microbial growth. This definition was further evolved to animal feed supplements which exerted a beneficial effect by contributing to intestinal flora [1]. With further advancement of knowledge in the field, the term
However, the widely accepted and currently in use definition is the one put forth by the World Health Organization:
“Probiotics are live microorganisms which, when administered in adequate amounts confer a health benefit on the host.”
To summarize:
Fermented dairy and other food products were produced and utilized for nutritional and therapeutic purposes long before the discovery of microorganisms. The discovery of fermentation was itself an incidence of serendipity. However, with the discovery of Lactic acid-producing bacteria by Pasteur in 1857, it was Pasteur and his successors who had a significant impact on the understanding of the microbiology involved in the process of fermentation [9]. The idea of using beneficial bacteria attracted interest along with the advances in microbiology and biotechnology in the following decades.
Research on the application of probiotic microorganisms in aquaculture started over two decades ago. Microorganisms, especially lactic acid bacteria (LAB), have long been associated with food fermentation. Dating back to 3200 BC, when the Egyptians produced fermented milk and dairy products during the Pharaonic period [10, 11]. Applications of probiotics in the field of animal husbandry gained popularity in the 1960s. In the 1980s, the most common probiotics for animal feeds belonged to three bacterial and one yeast genera: Lactobacillus, Streptococcus, Bacillus, and Saccharomyces spp. Lactobacillus sp. is recognized to produce potent antimicrobial compounds in order to establish their preservative and probiotic effects [12, 13] and have been consumed in the form of diverse food supplements through thousands of years and are “generally regarded as safe” (GRAS) [14, 15].
Probiotics are an innate component of a healthy intestinal microbiota in humans and other animals. These colonize the gut through the diet or other non-dietary sources that are consumed by the organism. Novel species and strains of probiotic bacteria are being constantly identified with the exploration of previously unexplored sources. However, prior to incorporating such potential probiotic strains into products, their efficacy has to be carefully assessed based on a battery of criteria (Figure 1).
Probiotics: Characteristic criteria.
Foremost among such criteria is the safety of the host. Most of the probiotics in use today have been isolated from natural sources with a long history of safe use. Acid and bile salt stability of such strains are self-evident properties as these were able to colonize the intestinal tract. The development of probiotic products requires that the strains should also have antimicrobial activity and antibiotic resistance to the commonly administered drugs. Adhesion to intestinal cells and colonization of the gut are among the other primary requisites [3, 4, 5, 7, 16, 17, 18, 19].
Acidic conditions (pH < 3.0) in the stomach act as a natural barrier to microorganisms and prevents most of them from passing into the intestine. Acid tolerance is, hence, a preliminary character for any strain that is expected to have probiotic effects [16, 20]. Resistance to pH 3.0 for 2 h is one standard test to determine the low pH tolerance of potential probiotic isolates [21]. The exact mechanism of tolerance to low pH conditions is not yet known. The next barrier for a potential probiotic to survive is the bile salt in the intestine, the normal level of which is around 0.3%, but may range up to the extreme 2.0% during the first hour of digestion. In conjunction with acid tolerance, it has been used widely as a selection criterion of potential probiotics [22]. Bile resistance of potential probiotic strains is related to the activity of the enzyme- bile salt hydrolase (BSH) which catalyzes the hydrolysis of conjugated bile, hence reducing its toxic effects [23]. In addition, according to Ganzle et al. [24] bile resistance can be increased due to the protective effect of some food components.
The potential of lactic acid bacteria and probiotic yeast to inhibit the growth of other microorganisms in the intestine is a valuable feature for considering their application in the development of functional foods. The antagonistic property of the probiotic strains against pathogenic bacteria may be exerted by either competitive exclusion, a decrease of redox potential, inter-bacterial aggregation, or production of antimicrobial substances including organic acids, other inhibitory primary metabolites such as hydrogen peroxide, and special compounds like bacteriocins and antibiotics [25, 26]. This property enables the probiotics to alter the resident intestinal flora and modify it for the benefit of the host [27].
The ability of probiotic strains to endure and survive in the presence of antibiotics ensures the maintenance of healthy intestinal microbiota during the treatment of microbial infections. LAB has been shown to exhibit susceptibility to a broad spectrum of antibiotics. Although isolates of lactobacilli with strong resistance to penicillin, cephalosporins, and bacitracin have been recovered from the human gastro-intestinal tract and dairy products, in most of these cases, this resistance is not transmissible and represents an intrinsic characteristic of the organism [17, 28].
The health benefits of probiotics were proposed over a century ago by Eli Metchnikoff when he postulated that manipulating the intestinal microbiome could enhance health and delay senescence [29]. There is now sufficient scientific evidence supporting the incorporation of probiotics in the diet for health benefits. The best documented benefits include- relief from bowel disorders such as lactose intolerance, antibiotic-associated diarrhea, and infectious diarrhea, and allergy. Emerging evidence has indicated the potential role of probiotics in managing different kinds of cancers as well. Multiple
Probiotics are known to exert their effects by influencing the intestinal microflora and protecting against infections, alleviating lactose intolerance, reducing blood cholesterol levels, improving weight gain and feed conversion ratio, and also stimulating the immune system [33]. Lactic acid bacteria (LAB) are a part of normal gut microflora in humans and some other animals and are known to produce lactic acid, hydrogen peroxide, diacetyl, acetaldehyde, and bacteriocins which are able to inhibit the growth of harmful microorganisms [34, 35].
Probiotics are mostly administered as live supplements in diet and exert diverse effects on the host. These influence the intestinal luminal environment and the innate and adaptive immune response systems [34, 36].
The use of probiotics for enhancing bio-growth parameters and in improving disease resistance ability has been well documented in aquaculture of fish for human consumption [37, 38, 39, 40, 41] but research on the effect of feeding probiotics in ornamental fishes is still an under-explored research territory.
Although most probiotics known so far are Gram-positive, with lactobacillus and bifidobacterium being the main species used for treatments of intestinal dysfunctions [42], some Gram-negative bacteria, such as
There is strong evidence that the administration of probiotics is able to down-regulate over-expressed immune responses in subjects with autoimmune/immune-inflammatory disorders and enhance specific aspects of immune function in healthy subjects. Schiffrin and colleagues reported enhanced phagocytic capacity of peripheral blood leucocytes (polymorphonuclear and monocytes) in healthy human adults administered with specific strains of probiotics [49, 50, 51, 52]. The effectiveness of probiotics in enhancing the immunogenicity of mucosal and systemic vaccines has also been reported. It has been reported that probiotic administration could induce antibody responses to completely unrelated antigens and to themselves [53, 54].
Probiotics have been obtained from a wide variety of traditionally fermented and preserved products that include dairy-based items like fermented milk, cheese, buttermilk, milk powder, and yogurt [55, 56]. Non-dairy food sources like soy-based products, cereals, and a variety of fermented juices have also proved to be promising [57, 58]. With more and more sources being explored, new strains and species of probiotics are being added to the list.
Fish and their products have emerged to be a potential source of novel probiotics that can be utilized to enhance the value of human nutrition [59]. Fish gut confers a congenial environment for colonization of bacteria abundant in the aquatic environment. Most of the probiotic bacteria isolated from the fish gut are either aerobes or facultative anaerobes. Worldwide, fishes have been consumed in diverse formats. Among some ethnic groups, there has been a tradition to preserve fish by drying and fermenting for enhanced shelf-life. In the North-eastern states of India, freshwater fish have been fermented by traditional practices into products such as Utonga-kupsu, Hentak, and Ngari. Workers have studied the bacterial communities in these products and isolated
Country/state/region | Fish species | Bacteria isolated | Accession No. | References |
---|---|---|---|---|
Manipur (India) | [60, 62] | |||
JX 847611 | ||||
KU945827 | [63] | |||
JX847608 | [64] | |||
KX953135 | [65] | |||
Meghalaya (India) | JN680708 | [66] | ||
JN680707 | ||||
JN680706 | ||||
JN680705 | ||||
HQ141620 | ||||
HQ141621 | ||||
H Q141622 | ||||
H Q141623 | ||||
HQ141624 | ||||
Assam (India) | KR706310 | [67] | ||
NE India | [68] | |||
Malaysia | [69] | |||
[8] | ||||
Thailand | [7] | |||
MG798679.1 | [70] | |||
Phillipines | [71] | |||
Probiotics isolated from fish.
The processes like fermentation, salting, drying, and smoking are the popularly followed traditional methods of preservation of fish [72, 73]. As evident from the list (Table 1) lactic acid bacteria have been found to be predominant in most of the fermented fish products. However, the microbial diversity of these products also encompasses some species of
The fish gut microbiota embodies diverse enzyme-producing microorganisms capable of producing multiple hydrolytic enzymes that aid in the digestion of carbohydrates, proteins, and lipids [81, 82].
Although the above list is not comprehensive, it represents the potential of fish and their products as a source of novel probiotics. The knowledge of the health benefits of fermented fish products has been utilized by many cultures worldwide and this information can be utilized for the development of probiotic products for human consumption.
The incorporation of probiotics from fish and fish products into the development of functional foods containing known probiotic strains can provide alternatives in therapeutics and ensure food security. Isolation and standardization of bacteriocins and other metabolites from probiotics can lead to the development of functional foods for individuals surviving on a vegan diet.
The host- probiotic relationship can be regarded as evolutionarily one of the most primitive associations. It represents a dynamic relationship that is influenced by dietary and other intrinsic and extrinsic factors. The kind of diet consumed by the host plays an important role in the maintenance of the probiotic microbiome in the body. On the other hand, a healthy probiotic microbiome in the host ascertains good growth and health of the host. The various health benefits and the potential role of probiotics in various human diseases have been highlighted in this chapter. As the kind of diet consumed influences the gut microbiome significantly, it, therefore, becomes essential to explore this intricate food-host-probiotic relationship in order to understand human health and diseases. The traditional food- preparation practices evolved through close observation of the effect of food on human and animal health. Hence, exploration of such traditionally prepared foods can reveal some novel probiotics with potential therapeutic applications. In this chapter, some of such sources of probiotics have been listed. However, there is an urgent need to study these in detail as most of them have not been completely characterized to the extent of their utilization for human applications.
The authors declare no conflict of interest.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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These surfaces play a significant role in different processes like icing delay, anti-frosting, boiling, condensation, drag reduction, self-cleaning, etc. The present study comprises of different techniques for the fabrication of super-hydrophobic surfaces. These techniques include chemical etching, solution immersion, laser electrodeposition, template deposition, spray coating, various others. Important characteristics of super-hydrophobic surfaces like durability, storability, corrosion resistance, etc. are achieved differently by different methods. Also, some methods are simple, rapid, cost-effective and versatile. Moreover, various heat transfer applications of super-hydrophobic surfaces like boiling, condensation, icing delay, drag reduction, etc. have also been discussed in this chapter.",book:{id:"6631",slug:"heat-transfer-models-methods-and-applications",title:"Heat Transfer",fullTitle:"Heat Transfer - Models, Methods and Applications"},signatures:"Hafiz Muhammad Ali, Muhammad Arslan Qasim, Sullahuddin Malik\nand Ghulam Murtaza",authors:[{id:"187624",title:"Dr.",name:"Hafiz Muhammad",middleName:null,surname:"Ali",slug:"hafiz-muhammad-ali",fullName:"Hafiz Muhammad Ali"},{id:"233669",title:"MSc.",name:"Arslan",middleName:null,surname:"Qasim",slug:"arslan-qasim",fullName:"Arslan Qasim"},{id:"236423",title:"MSc.",name:"Sullahuddin",middleName:null,surname:"Malik",slug:"sullahuddin-malik",fullName:"Sullahuddin Malik"},{id:"236424",title:"MSc.",name:"Ghulam",middleName:null,surname:"Murtaza",slug:"ghulam-murtaza",fullName:"Ghulam Murtaza"}]},{id:"60855",title:"Calculations of Heat Transfer in the Furnaces of Steam Boilers According to the Laws of Radiation of Gas Volumes",slug:"calculations-of-heat-transfer-in-the-furnaces-of-steam-boilers-according-to-the-laws-of-radiation-of",totalDownloads:1542,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"The laws of heat radiation from black body and the laws of Stefan-Boltzmann (Jožef-Ludwig), Max Planck, and Wilhelm Wien are fundamental laws of physics. All in all, a little more than 30 fundamental laws of physics, studied by pupils and students worldwide, were disclosed. Scientific disclosure of fundamental laws influences mainly power technology, fuel, and energy resource saving. In the late nineteenth century, the laws of heat radiation from gas volumes and the laws of Makarov were disclosed. Since the radiation laws from blackbody are fundamental laws of physics, then the laws of heat radiation from gas volumes are fundamental laws of physics. The effect of using laws of heat radiation from gas volumes on fuel saving and reduction of development pressure on the environment in many countries of the world is shown.",book:{id:"6631",slug:"heat-transfer-models-methods-and-applications",title:"Heat Transfer",fullTitle:"Heat Transfer - Models, Methods and Applications"},signatures:"Anatoly N. 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The many passive methods for increasing heat transfer rate include various components located in the fluid flow path, such as twisted tapes, coiled or tangled wires, and nozzle turbulators. The present paper represents a comprehensive review that focused on heat transfer enhancement methods with coiled wire and twisted tape inserts since the installation of inserts is easier and more economical. The thermodynamic performance of heat exchange components is also affected by the flow conditions such as laminar or turbulence. The present review comprises investigations on the enhancement of heat transfer using twisted tape and coiled wire inserts in laminar and turbulent flow region.",book:{id:"6631",slug:"heat-transfer-models-methods-and-applications",title:"Heat Transfer",fullTitle:"Heat Transfer - Models, Methods and Applications"},signatures:"Orhan Keklikcioglu and Veysel Ozceyhan",authors:[{id:"234855",title:"Prof.",name:"Veysel",middleName:null,surname:"Ozceyhan",slug:"veysel-ozceyhan",fullName:"Veysel Ozceyhan"},{id:"234870",title:"Ph.D. Student",name:"Orhan",middleName:null,surname:"Keklikcioglu",slug:"orhan-keklikcioglu",fullName:"Orhan Keklikcioglu"}]}],onlineFirstChaptersFilter:{topicId:"704",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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