\r\n\tThere are generally two types of masonry: brick and stone masonry. Brick masonry: a type of masonry that uses bricks. However, masonry is further divided into "clay work," which uses clay to fill various joints with bricks to build walls, and "cement masonry," the cheapest type of masonry. Masonry: this is the art of building with bricks or stone. The ability of masonry to support the load imposed by the structural elements above it is called strength. The application of loads to masonry creates internal stresses and deformations. The brand of mortar and brick, the shape and size of masonry materials, and the thickness and density of mortar joints affect the strength of masonry. The ability of masonry to maintain its position under horizontal load is called stability. This property limits the height of masonry depending on its thickness and the magnitude of wind loads. The thermal conductivity of bricks of different types (silicate, ceramic, facing, refractory) is considered. A comparison of bricks in terms of their thermal conductivity is made; the thermal conductivity coefficients of refractory bricks are presented at different temperatures - from 20 to 1700°C. The thermal conductivity depends mainly on the density and the configuration of the voids. Architecture and construction consist of various elements for building works, and masonry is the main element with which these constructions are realized. Masonry is a piece of fired clay with a rectangular shape and is used to build walls and structures. Nowadays, eco-masonry can be made of different materials that offer a variety of advantages, but all of them offer benefits at the level of the environment and sustainability; some of these utensils are plastic bottles, clay, etc. The book addresses the holistic issue of using modern masonry in construction. This book interprets masonry as an essential theme of contemporary architecture and sustainable construction. It is one of the most valuable materials in the history of mankind.
",isbn:"978-1-83768-126-6",printIsbn:"978-1-83768-125-9",pdfIsbn:"978-1-83768-127-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"85ef86d046d15e7d4b1988f1ec5dd750",bookSignature:"Prof. Amjad Almusaed and Prof. Asaad Almssad",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12061.jpg",keywords:"Unreinforced Masonry Buildings, Masonry in Sustainable Building, Energy Saving and Masonry, Eco-Friendly Masonry, Modern Architecture and Masonry, Masonry and Human Behavior, Esthetic and Masonry, History of Advanced Masonry, Structural Masonry, Modeling of Masonry Structures, Modern Masonry Manufacturing, Masonry Walls",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 20th 2022",dateEndSecondStepPublish:"June 17th 2022",dateEndThirdStepPublish:"August 16th 2022",dateEndFourthStepPublish:"November 4th 2022",dateEndFifthStepPublish:"January 3rd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"20 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Prof. Amjad Almusaed, affiliated with Jönköping University has carried out a great deal of research and technical survey work and has performed several studies in these areas. 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First, the Chapter begins with an examination of the historical development of QC from the Middle Ages (pre-Industry 1.0 revolution). Second, gives an overview of evolution of Smart Manufacturing and Quality Control, with emphasis on chronological trends of Industry revolutions up to date. Third, the concept of QC from the Middle Ages to 20th century. Fourth, it conceptualised the QC in Smart Manufacturing or Industry 4.0 revolution. Fifth, the Chapter gives an in-depth evolution of QC into Smart Quality Control Systems (SQCS) or Intelligent Quality Control Systems (IQCS), benefits, and lastly, summary of the Chapter.
\nHistorically Quality Control (QC) can be traced back to the times of pre-Industry 1.0 revolution when the modes of productions were still in their infant stage or Iron Age. During this period Human to Machine (H2M) interactions were still not common in the manufacturing/assembly lines. And humans were not specifically and strategically positioned within the production lines to ensure that products, which do not meet specifications are eliminated before end of the production processes. This is because the production was always manned by Artisans working with some few workers using simple and less mechanised tools of production. The manufacturing processes continued with the Artisans being solely responsible for the product quality, while the consumer was expected to apply the principle of ‘
The development of the present QC can be traced to the period of Hawthorne studies between 1924 and 1932, which highlighted the significance of social and psychological work climate [3]. In the same period, Shewhart also developed Statistical process control, which later became known as “Statistical Quality Process” (SQP). Statistical Quality Control (SQC) emphasised the products’ design and production. Over the years though the concept of quality has developed into a discipline, a complex set of principles and assumed truths that define quality of goods and services is to be assessed, managed, delivered and assured [3]. During and until late into Industry 1.0 revolution, quality could be best described as “
From Industry 1.0 to Industry 3.0 revolution, a lot of changes have been made in manufacturing lines/assemblies with the aim of producing products that meet customers specific needs. However, with the entry into Industry 4.0 revolution, organisations have moved from Human to Machines (H2M) production to Machine to Machine (M2M) intensive production, altering the way QC is managed in the manufacturing processes. Industry 4.0 revolution or Smart/digital manufacturing, with more emphasis on Big Data Analytic, Cyber-Physical Systems, 3-D printing, interface between M2M and Artificial Intelligence in the manufacturing processes [5]. Artificial intelligence (AI) can be conceived as the simulation of human intelligence in machines that are automated to think like humans and can imitate human behaviours [6]. This term may also refer to any machine, which displays attributes related to human minds such as learning and problem-solving.
\nThe fourth industrial revolution, or Industry 4.0 revolution (I4.0R), has become a reality today (Figure 1). The political debate about the term Industry 4.0 revolution focuses equally on the important and abstract objectives. For its promoters, Industry 4.0 revolution, though coined in Germany is not only about improving Germany’s international competitiveness, but also perceived as means for solving some of the urgent global problems for example, climate change that has created new demand for the increased consumption of renewable and non-renewable resources. While some of the problems are specific national challenges such as, labour supply that is ever-changing due to demographic shifts [7, 8], Industry 4.0 revolution is focused on smart products, procedures, and processes (smart production). A key element of Industry 4.0 revolution is, therefore, the Smart Manufacturing (Figure 1). Smart Manufacturing or Industry 4.0 revolution are Cyber-Physical Systems, physical systems integrated with ICT components. These are autonomous machines that can make their own decisions based on machine learning algorithms and real-time data capture, analytics results, and recorded successfully past behaviours [9].
\nChronology of industry revolution. Source: Author’s own illustration.
The Smart Manufacturing controls the fast-growing complexity, while also boosting production efficiency. Therefore, Smart Manufacturing is about direct communication between man, machine and resources to produce Smart products and services. Furthermore, Smart products know their manufacturing process and future applications. Equipped with these types of knowledge and intelligence, these gadgets actively support the production and documentation process. This will create value chain capable of answering questions such as (“
Industry 4.0 revolution concept, therefore, encompasses not only value creation, but also work organisation, business models and downstream services. It performs this by using information technology networks of production, marketing and logistics. This enables it to capture all resources, production facilities and warehousing systems. The re-organisation thus, extends from the energy supply and smart power grids through to advanced mobility concepts (Smart mobility, Smart logistics) [12, 13]. However, on the technical side the concept is based on integrating Cyber-Physical Systems into production and logistics. In this Smart environment the concept of the Internet of Things (IoTs) and services that were already devised a decade ago have actually now become a reality. This process involves developing people and capital mobility, changing modes of production, consumption, learning, working and leisure, and increasing world-wide competition. In the subsequent subsection, we try to highlight the concept of quality control in Smart manufacturing.
\nQuality is as old as mankind on earth. It is possible that the quality of goods and services rendered has been monitored, either directly or indirectly since time immemorial [1, 2]. In the ancient Egyptians history, a commitment to quality in their pyramids was well demonstrated, similarly with the Greek architecture of the 5th century B.C. Such quality of work was evidenced in Roman-built cities, churches, bridges and roads that inspire the modern constructions [1, 2]. From the Middle Ages up to nineteenth century, the production of goods and services were predominantly confined to Artisans, a single person or small groups. These groups were mostly family-owned businesses, hence the responsibility for controlling the quality of a product or service rested with the Artisans or small groups [1, 2].
\nThe quality of the goods and services rather followed the principles of “
However, beginning the early twentieth century through to 1930, a second wave evolved, that was referred toas the “
Then there came the period from 1920 to 1940 or World War II period, which saw the next phase in the evolution of QC. This period was known as the “Inspection quality control” [14]. The introduction of improved machines and equipment for industrial and manufacturing as a result of Industry 2.0 revolution, and increased demand for industrial and manufactured goods due to World War II, resulted in increased production volumes. However, as workers who were reporting to one foreman grew in numbers, it became apparent that these workers needed to be kept under close watch as a way to have control over the operations. This resulted in inspectors being assigned the tasks of quality check of the product after certain operations were completed [2]. Quality standards were set, and the inspectors compared the quality of the items produced against those standards. Any product found not meeting the set standards or, defective was put separately from those that met standard. The nonconforming products were reworked, if possible, or rejected altogether. It is at this period that the aspects of Statistical Quality Control (SQC) were being developed in the United States, however, it did not immediately gain wide usage in the United States industries [2]. Walter A. Shewhart of Bell Telephone Laboratories proposed the use of statistical charts to control the variables of a product, which later became to be known as “Control charts” (or Shewhart control charts). These played a vital role in Statistical Process Control. This was followed by H.F. Dodge and H.G. Romig, also from Bell Telephone Laboratories, who also pioneered work in the areas of acceptance sampling plans. These plans were to later to substitutes for 100 percent inspection [2].
\nThe eve of 1930s saw the application of acceptance sampling plans in industry, both domestic and abroad. Walter Shewhart continued his efforts to promote to industry the fundamentals of statistical quality control (SQC). In 1929, he obtained the sponsorship of the American Society for Mechanical Engineers (ASME), the American Statistical Association (ASA), and the Institute of Mathematical Statistics (IMS) in creating the Joint Committee for the Development of Statistical Application in Engineering and Manufacturing. During these periods, the interest in the field of QC started to gain acceptance in England. The British Standards Institutions Standard 600 (BSIS-600) dealt with the applications of statistical methods to industrial standardisation and QC [2]. In the United States, J. Scanlon introduced the Scanlon plan, which dealt with improvement of the overall quality of work life [14]. Thereafter, the U.S. Food, Drug and Cosmetics Act 1938 had jurisdiction over procedures and practices in the areas of processing, manufacturing, and packaging.
\nThe next phase of QC was the evolution process of the Statistical Quality Control (SQC), which took place between 1940 to 1960 [2, 14]. During these periods, the production of industrial and manufactured goods increased as a result of World War II and population explosion. However, because of mass production, 100 percent inspection became impossible, hence opening the way to the sampling plan [2]. In 1946, the American Society for Quality Control (ASQC) was established and immediately got renamed the American Society of Quality (ASQ). Then later on, the U.S. Military in 1950 developed a set of sampling inspection plans for attributes called MIL-STD-105A, which was modified to MIL-STD-105B, MIL-STD-105C, MIL-STD-105D and MIL-STD-105E. This was later followed by a set of sampling plans by the U.S. Military in 1957 [2].
\nAfter suffering humiliating defeat at the hands of the allied forces in the World War II in 1945, Japan wholeheartedly embraced the philosophy of SQC. This is after W. Edwards Deming visited Japan and lectured on these new ideas in 1950, which convinced Japanese engineers and top management of the importance of SQC as a means of gaining a competitive edge in the world market. The next person was J.M. Juran, another pioneer in QC who also visited Japan in 1954 and impressed upon Japanese on the strategic role top management plays in the achievement of a quality programme. The Japanese seized this opportunity and immediately realised the profound effects that these principles would have on the future of business, hence made a strong commitment to a massive programme of training and education [2].
\nThe changes in quality swept through Industrial 1.0 to 2.0 revolutions, when the new paradigm that we all know as the ‘
The term ‘quality’ in essence means different things to different people. This is because people value different features of a product, some view quality as product package, price, colour, durability etc. However, [19] defines quality as, ‘degree in which a set of inherent characteristics satisfies the requirements. The question is, what are these ‘inherent characteristics’ that a product must satisfy? The question can better be answered by;
The importance of quality control ranges from good image, increase in sales volumes and competitiveness, good reputation, customer loyalty, just to mention a few. Global competition, customer heterogeneity, and technological change have altered the way the QC should be carried out in organisations. The traditional quality control has been rendered nearly obsolete by Industry 4.0 revolution technologies such as Big Data Analytics, Artificial Intelligent (AI), Cyber Physical Systems (CPS), Augmented Reality (AR), and Robo-Mate System gave birth to Smart Quality Control Systems (SQCS) or Intelligent Quality Control Systems (IQCS) as Manufacturing processes transforms itself to Smart Manufacturing [21, 22]. In Smart Manufacturing, AR can allow production managers to view productions KPIs and have an intra-factory overview of workstations and production lines in real-time for monitoring, identifying, analysing, diagnosing and resolving problems and flaws, a thing that used to be performed by human working in the production line. In the following subsection, we discuss the quality control in Smart Manufacturing.
\nAlthough the past three Industrial revolutions had quality control (QC) well entrenched in the manufacturing and industrial complexes, the application of the QC was more routine based on sampling plans and inspections. This was due to the fact that the three industrial revolutions’ manufacturing and industry were characterised by mechanisation, waterpower, and steam power (Industry 1.0 revolution); Mass production, assembly line, and electricity (Industry 2.0 revolution). The distinctive features of these two Industrial revolutions were that they were both labour intensive, therefore, division of labour with emphasis on specialisation. However, Industry 3.0 revolution was anchored on computerisation and automation, hence eliminating some manual work that were carried out by human beings. Goods produced were of high quality compared to the previous two Industry revolutions as automation and computerisation were both introduced into the manufacturing and industrial complexes to aid in QC [23, 24]. The question is how do quality control (QC) works under Smart Manufacturing? In the subsequent section, the Chapter reviews some of the current literature to conceptualise QC in the Smart Manufacturing context.
\nThe concept of Intelligent Quality Control Systems (IQCS) or Smart quality control systems (SQCS) is founded on the premise that, in Smart Manufacturing production, quality control (QC), is driven by the infusion of Big Data Analytics, Artificial Intelligence (AI), Cyber-Physical Systems (CPS), Robotics and intensity of Human-to-Machine (H2M) interactions. The concept replaces the traditional QC systems in the manufacturing processes, as automation take over most of the operations or tasks that were routine tasks performed by human. Smart quality control is mainly executed to physically manage various Smart machines or tools through a cloud enabled platform. These technologies are capable of communicating both with the products (Smart products) and their environments. They are capable of detecting any slight defects and delays that could hamper manufacturing processes, and then communicate the same to the shopfloor, using fitted sensors [22, 25]. These gadgets work autonomously to create seamless communication between themselves. For example, [21, 26] installed sensors, utilised simulation and AI techniques assist in design and implementation of automatic machine model that predicts machine health status, which in turn can diagnoses any quality defects that could results from the machining failures. This result in a cost-effective solution in monitoring the production process to improve the quality of the products based on Industry 4.0 technologies.
\nTherefore, QC in Smart Manufacturing or Industry 4.0 revolution seem to take a different route as Industry 4.0 revolution is envisaged to leverage on a holistic automation, business information, and manufacturing execution architecture to improve industry with integration of all aspects of production and commerce across company boundaries for greater efficiency [27]. Industry 4.0 revolution is a complete departure from past three predecessors in several ways. First and foremost, Industry 4.0 revolution has come with Smart factories, Industrial Internet of Things, Smart Manufacturing, and Advanced Manufacturing, which were not experienced or witnessed in the past three successive Industrial revolutions. Second, Industry 4.0 revolution workplace emphasises so much on the Smart workers, Cyber Physical and Robotics in all the sphere of its Manufacturing and Industrial operations. The Internet of Things (Smart manufacturing, Additive Manufacturing, AI) have transformed the traditional production process of assembly lines with the introduction of asynchronous systems where predetermined workflows based on production work orders are running enterprise business systems [27]. Hence, making production steps that are centrally in communication to each Manufacturing station, which is harmonised with the assembly line.
\nIn contrast, asynchronous manufacturing is based on I4.0 revolution concept in which components in the production flow using auto-identification technology to inform each machine and operator on what needs to be done to produce customised end product. This activity takes place at each step of the production process. In this process, the machines are more flexible, which make them adaptable to the requirements for the part being made at each production steps. This entire concept is a product of Industry 4.0 revolution. The systems assist in achieving a highly flexible, lean, and agile production process that allow for a variety of distinctive products to be produced in the same production facility. The process is based on the premise of profitable mass customisation that enables the production of small lots (even as small as single unique item). This is due to the ability to rapidly configure machines to adapt to customer-supplied specifications and additive manufacturing [27]. Figure 2 below gives a snapshot of Manufacturing production process and the quality control under Smart Manufacturing. Inputs- denotes Smart raw materials, and Smart workers that are capable to communicating with Robotics to execute the tasks. Such systems comprise production facilities, storage systems and smart machines which trigger actions, exchange information complete autonomously and are able to control each other independently [8, 28].
\nIntelligent quality control Systems in Smart Manufacturing. Source: Author’s own illustration.
Smart raw materials will be detected by machines without necessarily having to be verified or inspected as the case in the past. The machines fitted with sensors will be able to differentiate between quality inputs (Smart raw materials) and defects, if possible reworked, or discarded all together, a thing that was formerly done by human beings in the traditional manufacturing set up (see, Figure 2). Inputs will have Smart workers, who are capable of interacting with computers and Robots. The Smart Manufacturing is fully equipped with actors, sensors and CPS where “human beings, machines and resources communicate with each other as naturally as in a social network” [8, 28] as shown in Figure 2.
\nIn Figure 2, Smart Manufacturing process begins with the input as smart material (because these materials are fitted with microchips, sensors), which enable them to be recognised and detected by the intelligent machines. The fact is, the material can be configured or reconfigured according to the Smart Manufacturing requirements, if found not to meet the specific product manufacturing specifications, then it can be discarded or reworked. This allows for the smooth flow of manufacturing process. This results in an improved finished product quality and reduced level of production errors [5, 25]. The implementation in the technology production process namely, ICTs, sensors technology and robotic technology, have the ability to record the production process in each element (instead of sampling and control) and detecting errors that occur during the process [25]. If errors occur or are detected, the machines can be adjusted in real time accordingly.
\nIn the manufacturing process, there are Smart machining, Smart monitoring, Smart control, and Scheduling (Figure 2). Cyber-Physical Systems enable Smart machine tools to capture the real-time data and send it to a cloud-based central system so that machine tools and their twined services could be synchronised to provide to Smart Manufacturing solutions. While, Smart monitoring, monitors the operations, maintenance, and optimal scheduling of manufacturing systems. Smart monitoring assist in Smart Manufacturing by giving warnings/alerts if some abnormality occurs to machines/tools. In addition, Smart control, though can be executed to physically manage various smart machines or robot through Cloud enabled platform [5] but do allow the end-users to switch off a machine or robot via their Smartphones [29]. This allows the decisions to be reflected in frontline manufacturing sites such as robot-based assembly lines or Smart machines (Figure 2). Then finally, Smart scheduling which includes advanced models and algorithms draw on data captured from sensors [5]. These data-driven techniques and advanced decision architecture is used in smart scheduling. Figure 2, with the assistance of data input mechanisms, the output resolutions are fed back to the parties through various means (feed loop) [5, 30]. Figure 2 for example, comprises Big Data, Clouding Computing, Internet, Simulation, Artificial Intelligence, and System Integration, which represent technologies, such as Additive Manufacturing, Autonomous Machines, and Human -to-Man (H2M) integration. These produce faster, stronger and more consistent than workers with a combination of new sensors and actuators and extensive data analysis [25].
\nIn Figure 2 above, process represents transformation process of Smart raw materials into final products. Industry 4.0 revolution comprises a high-resolution, adaptive production control (APC) such as Smart Control that can be achieved through development of Cyber-Physical production control systems [10]. In addition, Smart control is mainly executed to physically manage various Smart machines or tools through a cloud enabled platform [31]. End-users (Smart customers are able to get a smart product, which are tailored-made according to their personalised needs. In addition, smart customers are able to interact with smart products from smart manufacturing and could easily identify with such products. And if the product fails to meet their specifications [29], the decisions could then be timely reflected in frontline manufacturing sites such as robot-based assembly lines or smart machines [32], as shown in Figure 2 above. For instance, the Smart quality control in Smart Manufacturing is well illustrated by Changying Precision Technology Company’s factory in Dongguan city. This is the first unmanned factory run by computer-controlled robots, numerical control machining equipment, unmanned transport trucks, and automated warehouse equipment. It is said that about six hundred human assembly-line workers were replaced with this automation alone. The result was a fivefold reduction in manufacturing errors and an increase in production of more than 250 percent [27, 33]. This is a typical example of how quality control (QC) in Smart Manufacturing has been operationalised.
\nSmart Manufacturing or Industry 4.0 revolution is built around the concept of self-control or managing production processes requires open software and communications standards that allow sensors, controllers, people, machines, equipment, logistics systems, and products to communicate and cooperate with each other directly [5, 27]. This simply means the use of human beings in the manufacturing process particularly in the production/manufacturing processes as quality control inspectors, is minimised, if not eliminated. However, to embrace Smart Manufacturing in sustainable way, require that Manufacturing industries adopt technologies transformations with training and development programmes in order to fit their workforce with the new workplace requirements, such as new tools and technologies [11, 34]. This will ensure that gaps in skills and knowledge created by the Smart Manufacturing technologies do not have serious impacts on the workforce work life. Therefore, the implementation of Smart Quality Control Systems (SQCS) or Intelligent Quality Control Systems (IQCS) in Industry 4.0 requires further employee skills and competencies, such as ICT know-how, interdisciplinary competencies and special personality traits [34, 35]. This is because Human-to-Machine (H2M) collaboration that is necessary as some production tasks are too unstructured to be fully automatised.
\nIn the production assembly/manufacturing assembly, Virtual Reality (VR) and operator create ‘cognitive interaction’. For example, VR technology provides a combination of interactive reality and advanced simulations that can replicate a design, assembly, or manufacturing environment and allow the smart operator to interact with any (Machine tools, production line, hand-tool, a robot, a factory), with reduced risk and real time feedback as shown in Figure 2 [11]. In addition, VR, at product assembly stage, CAD models of parts, hand tools, and assemblies can be transformed into interactive simulations (assembly sequence). This can be used in the training of operators working in a complex assembly tasks, and at product manufacturing stage. [11] opine that VR brings to life the “virtual factory” as an integrated simulation model of the major subsystems of a factory layout (such as arrangements of machinery, equipment and inventories for smooth flow of work, material and finished products). These arrangements form continuous communication between humans to machines and products during the production process. This is enabled by Cyber-Physical Production Systems (CPPS) in order to execute its tasks. The overall aim is to decrease cost, time efficiency, and improve product quality, which requires a broad understanding of the enabling technologies as well as methods and tools [13].
\nProducts in Smart Manufacturing are ‘Smart’, with embedded sensorics that is used via wireless network for real-time data collection for localisation, for measuring product state and environment conditions [9]. In Figure 2, Smart products have control and processing capabilities, thus control their logistical path through the production and even optimise the production workflow. In addition, Smart products are capable of monitoring their own state during the whole lifecycle, including their lifetime or application [9].
\nAlready in use is the intelligent Quality Control Systems (IQCS), which has replaced the traditional QC in the manufacturing processes. In Smart Manufacturing, all aspects pertaining to products quality control are first defined. In the first step, the technical requirements for the quality control system in development are defined and documented. In addition, the final document is intended for as a working-document supporting the requirements process during the development of the quality control systems [13]. The introduction of intelligent-based quality control necessitates integration steps within and outside the manufacturing industry. It affects sensors and actuators as well as general manufacturing processes, like information and documentation flows. Furthermore, manufacturing partners or customers have to be integrated into the development as they are all part of the overall value chain (see Figure 2).
\nIQCS brings with it several benefits to those organisations that will be able to adapt the new technologies in Smart Manufacturing processes compared to traditional quality control has been part of the manufacturing processes in the previous three industrial revolutions. Such benefits are summarised as follows:
“Time to market” to develop, produce and market new products and services, requiring higher and faster innovation capability [36]. This is due to the cutting-edge technologies such Additive manufacturing, Industrial Internet of Things (IIoTs), Augmented Reality and Virtual Reality. These have eliminated wastes that were formerly associated with human errors hence creating lean production of products that are competitive globally. Augmented Reality (AR) assist in reducing defects, rework and redundant inspection by offering intuitive information and combining operator intelligence and flexibility with error-proofing systems to increase efficiency of manual work steps, while improving the quality of work [9, 11].
Increased “customisation” to satisfy individual consumer demands, in a buyer’ market, not anymore a seller’s one, leading to higher product individualisation; meaning products may not need to be produced in mass as before, because the manufacturers will be able to produce very small series (single product if needed). This technology provides fast configuration of machines and production process, as well as their adaptation to customer requirement [25].
Higher “flexibility” with faster and more versatile production processes able to produce smaller lot quantities with high quality and a cost-effective way [9, 22, 36].
“Decentralised” decision making with fewer organisational hierarchies be reduced.
Increased resource “efficiency” by using more efficient and closed loops, regenerative, and restorative physical and economic cycles, where products and raw materials retain their physical characteristics and value as much as possible [9, 36].
Quality control (QC) has evolved from the Middle Ages to the present time, with the changes in manufacturing industries. As industrial revolutions transformed itself, so is the QC systems. First QC started as ‘
However, in contrast to the previous Industrial revolutions, Industry 4.0 revolution or Smart Manufacturing has completely revolutionised how QC in manufacturing processes is practiced. Traditional QC systems has now given birth to Smart Quality Control Systems (SQCS) or Intelligent Quality Control Systems (IQCS), where machines have taken over most of the roles performed by human in the manufacturing. Technological development has made production/manufacturing processes to be more complex and complicated, yet simple in terms of networked processes created by the application of Cyber-Physical Systems, Additive Manufacturing, Artificial Intelligent, Augmented Reality, and Virtual Reality. These networked technologies assume the tasks and roles that were manually performed in the manufacturing processes, thereby eliminating human errors that were common in the products design and development. The use of 3-D or 4-D printing now enable manufacturers to produce prototypes and proof of concept designs, which simplify and speed up the processes of new product design and manufacturing [24]. Hence, resulting in the following benefits to the organisations; lower production costs, low logistic costs, and quality management costs, and others are improved customer responsiveness, customisation of mass production without significantly increasing production costs, more efficient use of natural resources and energy, and more friendlier working environment. These are some of the benefits of IQCS as Smart Manufacturing.
\nThe human body cells need the energy to maintain their functions. This energy is mainly provided by sugar, carbohydrates and fat. To utilize these nutritive substances and to produce energy in return, inspired oxygen (O2) from the air is needed. In the mitochondrial electron transport chain, O2 is the final electron acceptor to generate ATP within the eukaryotic cells [1]. Whilst O2 is needed for most life on earth, most of the earth’s atmosphere does not contain a lot of O2. From the surface of the planet, up to the border of space, the atmosphere contains a constant fraction of around 21% O2 (often expressed as the FiO2 of around 0.21), 78% of nitrogen, 0.9% argon and 0.1% of other gases like carbon dioxide, methane, water vapor, etc. At sea level, the partial pressure of the above-mentioned gases can be estimated to be 593 mmHg for nitrogen, 160 mmHg for oxygen and 7.6 mmHg for argon. Indeed, the weight of air is responsible for atmospheric pressure.
It’s well known that increasing altitude leads to quasi-exponential reductions in barometric pressure (PB). At the summit of Mt. Everest (8848 m), the PB is about one-third of the sea-level values. The reduced atmospheric pressure has therefore a direct influence on the partial pressure of inspired oxygen, which can be seen in Figure 1.
Relationship between barometric pressure (PB), partial pressure of inspired oxygen (PiO2) and altitude. PB and PiO2 decrease exponentially with increasing altitude at a constant FiO2 of 21%. The solid line represents PB and the broken line represents PiO2.
The inspired partial pressure of oxygen (PiO2) is lower than atmospheric oxygen partial pressure because water vapor is in the airways. The pressure of water vapor (PH2O), which is not dependent on atmospheric pressure but temperature, should be taken into account when PiO2 is calculated [2]. The inhaled air gases will get humified and warmed by the airways and as a result, the PH2O will adjust the partial pressure of all inhaled gases, including O2.
Accordingly, the product of PiO2 can be calculated using Eq. (1):
Since PB is known to be approximately 760 mmHg at sea level, PH2O is normally about 47 mmHg and O2 makes up to 20.93% (FiO2 of 0.2093), PiO2 is equal to 0.20932 multiplied by 713 mmHg.
Consequently, hypoxia is defined as a combination of PB and the FiO2 that results in any PiO2 under a normoxic value of 150 mmHg [3]. However, the duration of hypoxic exposures as well as the magnitude of PB reductions has a significant impact on the (patho-)physiological response. Examples of fast-changing normoxic to hypoxic environments are fast ascended on the mountain summits during mountaineering, military and rescue services and travels with fast transportation to altitude. Acute mountain sickness is well-known to occur due to extensive and fast decreases in Pb, normally beginning at an altitude of above 2500 m. The Lake Louis Consensus Group defined acute mountain sickness as the presence of headache in an unacclimatised person (recently arriving at an altitude above 2500 m), plus the presence of one or more of the following symptoms: gastrointestinal symptoms, fatigue and/or weakness, dizziness or a positive clinical functional score, resulting in a total score of ≥3 [4]. If not treated correctly, people with acute mountain sickness can develop high-altitude pulmonary oedema or high-altitude cerebral oedema [5]. However, if the human body is gradually exposed to hypoxic conditions, it can acclimatize and adapt.
The following chapters will focus on the main types of hypoxia, the physiological consequences of acute hypoxia and the clinical consequences of the current chapter.
Insufficient O2 supply to the human tissues can have various reasons and can lead to severely impaired body functions. There are four main types of hypoxia, which can be classified as hypoxaemic hypoxia, anemic hypoxia, stagnant hypoxia and histotoxic hypoxia.
One of the most common types of hypoxia is called generalized or hypoxic hypoxia, which is generated from the actual (natural/simulated) environment and inside the lungs. This type is caused by a reduction of the partial pressure of alveolar O2 (PAO2) [6]. This value is well known and a great help to calculate the partial pressure of oxygen inside the alveoli (as it is not possible to collect gases directly from the alveoli), which can be used for potential cell diffusion [7]. The alveolar gas equation uses three variables to calculate the alveolar concentration of oxygen, which can be seen in Eq. (2):
where PaCO2 is the partial pressure of carbon dioxide which is under normal physiological conditions approximately 40 mmHg. RQ is the respiratory quotient which is, the ratio of the volume of produced CO2 divided by the volume of consumed O2 during the same time [8]. Dependent on metabolic activity and diet, RQ is considered to be around 0.825 [9], within a physiological range between 0.70 and 1.00. Consequently, PAO2 at sea level is: 0.2093 × (760–47) – 40/0.825 = 100.7 mmHg. PAO2 is the main driving factor for alveolar diffusion and thus O2 supply on a cellular level.
Hypoxic hypoxia can be observed typically when FiO2 is low, during hypoventilation of the lungs or at the presence of pathological airway conditions. Low FiO2 levels can occur due to failure of gas delivery systems, inadequate supply from altitude simulating machines, or e.g., exorbitant inhalation of nitrous oxide during anesthesia [10]. Hypoventilation can occur due to insufficient respiratory rate, obstruction of airways, skeletal deformities, respiratory muscle paralysis, etc. Severe lung diseases (e.g., pulmonary fibrosis, pulmonary embolism) can also lead to alveolar-capillary diffusion blockade [11]. Hypoxic hypoxia affects the entire body. Typical symptoms are agitation and anxiety while low blood O2 goes along with increased heart rate, dyspnea and bluish color of the skin.
Anemic hypoxia is caused by reduced oxygen transport capacity in the blood [12]. The red blood cells (erythrocytes) are responsible for the transport of O2 through the body [13]. Around 90% of the erythrocyte is made up of haemoglobin, the iron-containing protein that binds O2 on its heme. Although, the arterial oxygen tension is normal at this type, reduced erythrocytes/haemoglobin or functional insufficiency of haemoglobin leads to impaired oxygen delivery to the tissues [14].
A deficiency in the number of erythrocytes can result, for example, from excessive blood loss after trauma. Other forms of the reduced number of erythrocytes can be present in case of abnormal red blood cell breakdown (haemolytic anemia) [15]. Increased haemolysis can be observed during hereditary spherocytosis, sickle cell disease or autoimmune diseases (e.g., aplastic anemia) [16].
Deficiencies of different factors can also lead to severe anemia. Iron is the main component of haemoglobin, giving the blood the red color and is the prime carrier of oxygen. During the physiological haemolysis, iron will be bound to the glycoprotein transferrin for transportation to the bone marrow, where it will be reused for haemoglobin synthesis. This process helps to limit an extensive loss of iron from the body. However, iron deficiency is one of the main causes of anemia, called microcytic hypochromic anemia [6]. This type of anemia can be caused by any factor which reduces the body’s iron storage, leading to small erythrocytes with reduced haemoglobin mass [17]. In contrast, deficiencies in vitamin B12 or folic acid can cause anemia due to abnormally enlarged erythrocytes and their immature precursors, called macrocytic hyperchromic anemia [18].
Functional insufficiency of haemoglobin is associated with reduced oxygen binding capacity. An example is an intoxication through excessive carbon monoxide inhalation. Compared to oxygen, carbon monoxide has a 200–300 times higher affinity to haemoglobin. After inhalation, carbon monoxide reaches the respiratory gas exchange zone and binds on haemoglobin [10]. This chemical binding process leads to the formation of carboxyhaemoglobin. Consequently, oxygen-carrying capacity is decreased which will lead to reduced oxygen transportation to the tissues and as a consequence tissue hypoxia [19]. Another possibility of functional insufficiency for the transportation of oxygen is methaemoglobinemia. Haemoglobin changes to methaemoglobin, when bivalent iron (Fe2+) is oxidized to Fe3+, which is worthless for oxygen transport [20]. Under normal circumstances, methaemoglobin reductase limits the build-up of methaemoglobin through the reduction of haemoglobin oxidation [21]. Patients with a deficiency of methaemoglobin reductase, strong oxidative stress (e.g., smoking) and medication can therefor experience very low concentrations of tissue oxygenation, demonstrating comparable symptoms as seen in hypoxic hypoxia. However, it must be mentioned, that the unfavorable conditions of low tissue O2 can be compensated better during hypoxic hypoxia than during anemic hypoxia.
Stagnant, also called ischemic or circulatory hypoxia takes place as a cause of insufficient blood supply to the tissues while the blood is normally oxygenated. Ischemic hypoxia can be observed on a central and local level [6].
Central circulatory hypoxia can often be observed in patients with cardiac manifestations. If the left ventricular output is for example decreased, blood flow to the organs is impaired [12]. This can also happen during shock or, at a local level after strong vasoconstriction (e.g., cold exposures) or venous stagnation of blood [22]. Oxygen can only be stored to the very limited amount within the human cells. Even myoglobin, binding O2 on its heme protein, has a very limited oxygen storage capacity [23]. Consequently, myoglobin is more involved in transportation than the storage of oxygen. Oxygen saturated myoglobin enables facilitated intercellular O2 transportation, because the oxygen-enriched myoglobin molecules can “move” within the cells (facilitated diffusion) which is extremely important at a low partial pressure of O2 (PO2) [24]. Although, the gas exchange rate on the alveolar level, the concentration of haemoglobin, oxygen content and tension are on a normal level, O2 extraction at the level of the capillaries will be increased [6]. This process will directly elevate the arteriovenous difference of blood O2 content leading to venous hypoxia. However, as the increased oxygen extraction is normally insufficient to supply the tissue with an adequate amount of O2, this process will lead to impaired cellular oxygen coverage and impaired functioning.
Histotoxic hypoxia or dysoxia is a state, where cells are unable to utilize oxygen effectively [12]. This is the case, when the mitochondrial terminal oxidation is disturbed while there is sufficient oxygen available in the blood. Dysoxia will therefore lead to a pathological reduction in ATP production by the mitochondria and is not preceded by hypoxaemia [6].
An example of histotoxic hypoxia is the intoxication with cyanides, which can occur from fire sources. Intravenous and inhalation of cyanide produce a more rapid onset of hypoxia than the oral or transdermal route due to the fast diffusion into the bloodstream [25]. The main effect of cyanide intoxication is related to the inhibition of oxidative phosphorylation, where oxygen is utilized for ATP production. Cyanide can reversibly bind to the enzyme cytochrome C oxidase, blocking the mitochondrial transport chain. This will cause cellular hypoxia and, as mentioned above, pathological low levels of ATP, causing metabolic acidosis and impairment of vital functions [26, 27].
Rapid ascends from sea level to altitude and sudden exposure to a hypoxic environment will immediately lead to acute physiological responses to adapt to the acute hypoxaemic situation [28]. The degree of acute hypoxic stress about time can lead to symptoms ranging from dizziness, feeling of unreality and dim visions to rapid unconsciousness [29]. Sudden exposure to the summit of Mt. Everest will for example lead to unconsciousness within 2 min. However, when the same amount of hypoxaemia is experienced over several days to weeks, one could function relatively well under these conditions. This adjustment is called acclimatization which is a complex process over time and shows great variability within individuals [29]. In the following chapters, the acute response to sudden exposure to a hypoxic environment is discussed.
The respiratory system will directly respond to the low oxygen availability in the air and is often seen as the primary defense against the hypoxic environment. Chemosensory systems will rapidly lead to increased pulmonary ventilation because of compromised O2 availability [30]. These regulatory responses can be attributed due to specialized chemoreceptors such as the carotid bodies in the arterial circulation and neuroepithelial bodies in the respiratory tract as well as the direct response of vascular smooth muscles to hypoxia [31].
Whilst hypoxia acts as a vasodilator in the systemic circulation, it has been observed, that the vessels of the pulmonary vasculature constrict under hypoxia, leading to pulmonary hypertension [32, 33]. Hypoxic vasoconstriction is intrinsic to the pulmonary vasculature smooth muscle cells and is initiated by the inhibition of K+ channels which set the membrane potential [34]. This process will lead to depolarization, activation of Ca2+ channels as a result of the electrical impulse and, as a consequence, an increase in cytosolic calcium levels and therefore constriction of the myocytes [31]. Pulmonary hypertension might help to match ventilation and perfusion within the lungs. However, pulmonary hypertension can also lead to severe pathological situations (e.g., altitude-related right heart failure).
Carotid bodies, sensitive to monitoring a drop in arterial O2 levels, and neuroepithelial bodies, detecting changes in inspired O2, respond immediately to decreased O2 supply [35]. Both respond by activating efferent chemosensory fibers to produce cardiorespiratory adjustments during hypoxic exposures [36, 37]. When low arterial PO2 is detected, the carotid body signals the central respiratory center to increase the (minute) ventilation. The increased ventilation of the respiratory tract can be primarily associated with an elevated tidal volume and an even greater elevation in respiratory rate [38]. This hypoxic ventilatory response counteracts the hypoxic environment by decreasing PACO2, increasing PAO2 and therefore improving oxygen delivery. Genetical determinants, as well as various external factors (metabolic and respiratory stimulants), lead to wide inter-individual variety of ventilatory response intensity [39]. The increased ventilatory response demonstrates that adaptive processes are taking place and a “good” ventilatory response is known to enhance acclimatization and performance and that a very low response may contribute to the formation of illness [39, 40]. However, hyperventilation will subsequently lead to hypocapnia (increased pH) known as respiratory alkalosis by reducing the amount of carbon dioxide in the alveoli [41]. This condition will cause the oxygen dissociation curve to shift to the left and to further keep respiratory ventilation high. However, hypocapnia will also counteract the central respiratory center activation and thus limit further ventilatory increases [40, 42]. On the other hand, to reduce respiratory alkalosis, more bicarbonate will be produced from the kidneys to decrease the pH toward normal levels. This means that pulmonary ventilation is driven by low arterial PO2 and limited due to hypocapnia-induced alkalosis at the same time. This becomes clear when looking into Eq. (3), defining the alveolar ventilation as follows:
VA is the alveolar ventilation, 0.863 is a constant, VCO2 is the CO2 output and PACO2 is the alveolar CO2. The ability to maintain oxygen homeostasis is essential and the physiological systems compete against each other to provide enough tissue O2 but also to maintain pH-homeostasis.
To compensate for tissue hypoxaemia, the cardiovascular system must respond to maintain body functions. This is accomplished by increasing cardiac output, which is the product of stroke volume and heart rate [43]. Consequently, an increase in one of these variables will also lead to an increased volumetric flow rate. Upon ascent to hypoxic environments, the sympathetic nervous system activation leads to an initial increase in heart rate, cardiac output and blood pressure via the release of stress hormones [40, 44]. Stroke volume remains low in the first hours which is a consequence of reduced blood plasma volume because of bicarbonate diuresis. This occurs as a result of the fluid shift from the intravascular space and the suppression of aldosterone [40]. Interestingly, the sympathetic nervous system activation remains increased even if one is well acclimatized to altitude [45]. In contrast to sympathetic activation, cardiac output decrease once a certain level of hypoxia is reached after several days [46]. After a few days, e.g., muscle tissue adapts and extracts more O2 from the circulating blood by increasing the arterial–venous oxygen difference. This reduces the demand for higher cardiac output. Reductions in stroke volume can be attributed due to decreased plasma volume as well as the above-mentioned increased pulmonary vascular resistance. From the systemic circulation perspective, the endothelial autocoids nitric oxide and prostaglandins have received more attention as they are potentially mediating hypoxic vasodilation in the vessels [47]. Hypoxic-induced vasodilation will therefor quickly increase the blood flow to O2-deprived tissues. Low PaO2 levels will increase Ca2+ concentration inside the endothelial wall which might lead to increased synthetization of vasodilating endothelial factors [48]. The smooth muscle cells of the blood vessels also have K+ ATP-channels, that are activated once the ATP/ADP quotient drops due to hypoxia. As a result of the increased conductivity of K+, the cell membrane is hyperpolarized, followed by relaxation of the vascular muscle cells and vasodilation. This is especially well evoked in coronary and vertebral vessels [49].
PAO2 is, as mentioned earlier, at sea level around 100 mmHg and will decrease at altitude. At sea level, around 96% of haemoglobin is bound to O2 which can be seen in Figure 2. The oxyhaemoglobin dissociation curve plays a crucial role in O2 transport and demonstrates the interaction between the oxygen carrying capacity of haemoglobin and changes in partial pressure of oxygen [50]. When PAO2 drops to 50 mmHg at altitude, only about 80% of haemoglobin sites are bound to O2. The sigmoidal shape of the curve minimizes an abrupt decline in oxygen-carrying capacity of the blood. Another crucial adaptive process is, that the dissociation curve will shift to the left [51]. This is mediated by respiratory alkalosis and therefore rise in blood pH. This left shift causes that at a PAO2 of 50 mmHg, instead of 80%, around 90% of haemoglobin is bound to O2. As a result, more oxygen is bound on haemoglobin and more oxygen can be unloaded to the tissues [52].
S-shaped oxyhaemoglobin dissociation curve at sea level (solid black line). The curve is shifted left due to respiratory alkalosis under acute hypoxic exposure (broken gray line).
The brain consumes around 20% of the available oxygen at rest and is very sensitive to insufficient O2 supply [53]. The ability to process large amounts of oxygen (over a relatively small tissue mass) is necessary to support the high rate of ATP production to maintain an electrically active for the continual transmission of neuronal signals [54]. From this perspective, it is clear that hypoxia can have negative effects on cognitive function [55]. From the literature, it is well known that various factors have an important influence on cognitive impairment during hypoxia, in case they occur. These include the grade of hypoxia (e.g. altitude height), ambient temperatures, performing exercise tasks, individual physiological responses and the influence of PB [56].
One of the most sensitive regions of the central nervous system is the cerebral cortex. However, acute exposure to extreme hypoxia can also cause changes within wide regions of the brain. Subtle changes in the white and gray matter were already observed during ascending Mt. Everest and K2, reducing movement control and planning [57]. Motor speed and precision are also negatively affected in altitude compared to sea level performance [58, 59]. The complexity of central execution tasks seems to play an important role when cognitive impairment is evaluated. Cognitive impairment seems to be more prominent when complex tasks must be solved rather than simple tasks [60, 61]. Indeed, altitude accidents that occur under hypoxia might be more related to poor judgment of complex situations as a consequence of hypoxic depression of cerebral function. However, also small mistakes or even small increases in reaction time [62] can also have fatal consequences.
However, the underlying mechanisms, why cognitive performance can be impaired during hypoxia are not fully understood [61]. Cerebral circulation, which is the product of arterial oxygen content and cerebral blood flow, is dependent on the net balance between hypoxic vasodilation and hypocapnia-induced vasoconstriction. It is well documented, that cerebral blood flow is increased under acute hypoxia to maintain cerebral O2-supply [54]. Cerebral blood flow increases, despite the hypocapnia, when arterial PO2 is less than 60 mmHg (altitude greater than 2800 m). Although, interindividual varieties in cerebral blood are linked to individual variations in the ventilatory response to hypoxia [63], cerebral oxygen delivery and global cerebral metabolism are well maintained under moderate hypoxia. If cerebral oxygen consumption is constant, the question arises of what causes the cognitive impairment at altitude. Cognitive changes might be related to specific neurotransmitters that are affected by mild hypoxia (e.g., serotonin, dopamine). Furthermore, alterations in blood flow and sensory displeasure, hyperhomocysteinemia and potential neuronal damage, and a decrease in catecholamine availability combined with psychological factors appear to play a key role for reduction in cognitive function during hypoxia [61]. In case cerebral tissue oxygenation is not maintained, brain injury will occur with fatal consequences [35]. Compensatory hyperventilation, tachycardia and increased cerebral blood flow can partially maintain cerebral oxygen delivery, however, if these mechanisms work inadequately, the brain will be the first organ to be compromised.
This chapter aimed to give an overview of the main hypoxia types and the main physiological consequences. Hypoxia can occur due to occupational responsibilities, recreationally but also under pathological conditions. Ascend to altitude or exposure to environments that lower the PiO2 will have direct consequences to the entire body systems, however various modulators such as PB, the severity of hypoxia, interindividual variability, health condition and others determine the physiological consequences and adaption processes. Exposing the body specifically to hypoxic environments can be used as a therapeutic tool, to increase sports performance or to achieve other goals [64]. However, it is important to precisely understand the different types of hypoxia and what consequences they have on the human body. Clinical manifestations of hypoxia underly inter-individual variations of cardiorespiratory and other physiological responses as well as the origin of hypoxia. In general, there are two major causes of hypoxia at the tissue level which are reduced blood flow to the tissues or reduced O2 content in the blood itself [65, 66]. As a result, four main types of hypoxia arise. First, hypoxaemic hypoxia, where the O2 transport to or through the alveoli is impaired [6]. Second, anemic hypoxia where the oxygen-carrying capacity is reduced due to e.g., severe blood loss, iron and folate deficiency, haemoglobin pathologies or functional insufficiency to carry O2 [10, 12, 14]. Third, stagnant hypoxia where the transport of O2 to the tissue is impaired while the blood may be sufficiently oxygenated [6]. Finally, histotoxic hypoxia exists, where the O2 is delivered to the tissues but they are unable to utilize oxygen effectively [12].
It is important to understand, how these types influence oxygen delivery to the tissues. The product of O2 content and blood flow is considered to reflect the oxygen delivery for the whole body (or to the individual organ system). As oxygen content is the sum of dissolved oxygen and that bound to haemoglobin, total oxygen delivery can be calculated according to Eq. (4):
DO2 is the O2 delivery (ml min−1); PaO2 is the partial pressure of oxygen (kPa); SaO2 is the arterial oxygen saturation in percentage; Hb is the haemoglobin content (g dl−1); 0.023 is the solubility of oxygen (in ml dl−1 kPa−1); 1.34 is Hüfner’s constant, the oxygen-carrying capacity of saturated haemoglobin (ml g−1); and blood flow (i.e., cardiac output) in dl min−1 [67]. From this equation, it can be seen that hypoxaemic hypoxia (via reduced PaO2 and SaO2), stagnant hypoxia (via reduced blood flow) and anemic hypoxia (via reduced haemoglobin content) may cause tissue hypoxia, as these three types reduce oxygen delivery. In contrast, there is no oxygen delivery deficiency in histotoxic hypoxia but rather an impairment of the tissue to use O2 [35]. Reduced oxygen tension, hypoventilation, ventilation-perfusion mismatch, right to left shunt and impaired diffusion of oxygen can all lead to hypoxia in the body [12].
The primary measurement to evaluate the hypoxic disease state is the analysis of arterial blood gas. Using this measurement, important parameters such as partial pressure of oxygen, partial pressure of carbon dioxide, acidity (pH), oxyhaemoglobin saturation and bicarbonate concentration in arterial blood can be assessed [68]. Management and treatment of persons under hypoxia should be started as soon as the evaluation has been successfully finished, and follows three categories: maintaining patent airways, increasing the oxygen content of the inspired air and improving the diffusion capacity [69, 70, 71]. Without adequate adaption processes and management, an imbalance between oxygen demand and oxygen delivery will occur leading to impaired homeostasis within the body. Therefore, healthcare practitioners (e.g., physiotherapists, sports scientists, exercise physiologists and others) should be able to understand the causes, types and consequences of hypoxia.
In this chapter, an overview is presented on the main types of hypoxia and the physiological consequences of the main systems. Hypoxaemic, anemic, stagnant and histotoxic hypoxia originate from different etiologies. Hypoxia to the tissues can be caused by any obstacle in the oxygen cascade, beginning from the O2 molecule in the atmosphere, until being the final electron acceptor within the mitochondria to generate ATP. However, the adult compensatory mechanisms to counteract the acute hypoxic state are mainly based on our ability to hyperventilate, adequately adapt the cardiovascular response and to increase oxygen uptake to provide enough tissue O2. This chapter might contribute to improving the understanding of the different types of hypoxia and to understand the physiological responses.
The author declares no conflict of interest.
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',metaTitle:"Order and delivery",metaDescription:"Our books are published online and are accessible for free. However, if you are interested in ordering your hardcover copy, you can do so by contacting our Print Sales Department at orders@intechopen.com. All IntechOpen books are printed on demand in full-colour and delivered in signature packaging through free DHL Express delivery. A selection of our books in soft cover is also available through Amazon.",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"Our books are available hardcover, printed in full colour and produced to the highest standards on PEFC™ and FSC certified paper, complying with principles of responsible forestry worldwide. The paper size is 180 x 260 mm (7 x 10.2 inches).
\\n\\nIntechOpen works with award winning print-houses and we hold to the fact that all of our printed products are of the highest quality.
\\n\\nIntechOpen books retail price range is:
\\n\\n100 - 159 GBP ex. VAT (available in USD and EUR)
\\n\\nDiscounts available:
\\n\\nBulk discounts are granted for orders of 10 copies and more.
\\n\\nThere is no minimum or maximum threshold on the quantity of book orders.
\\n\\nOrders have to be paid in advance and before printing. We accept payment in GBP, EUR and USD.
\\n\\nWe currently accept the following payment options:
\\n\\nWhen paying with a credit card, you will be redirected to the PayPal.com online payment portal.
\\n\\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\\n\\nIn accordance with the best security practice, we do not accept card orders via email.
\\n\\nThe combined printing and delivery time for orders vary from 7-15 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\\n\\nIf you do not receive your order within 30 days from the date your order is shipped, please contact us to inquire about the shipping status at orders@intechopen.com.
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\\n\\nCustoms: free shipping does not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\\n\\nP.O. Boxes cannot be used as a Ship-To Address.
\\n\\nIntechOpen partners do not provide shipping service from Europe to the countries listed below. Please refrain from mailing items addressed to the countries listed below, until further notice.
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\\n\\nRestricted Ship-to Countries:
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\\n\\nChina Publishers Services Ltd - CPS
\\n\\nRepresentative for: China, Taiwan, Hong Kong
\\n\\nIndia - CBS Publishers & Distributors Pvt. Ltd.
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\\n\\nRepresentative for Mexico, Chile and Colombia
\\n\\nMissing Link Versandbuchhandlung eG
\\n\\nRepresentative for: Germany, Austria, Switzerland
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\\n\\nRepresentative for: Czech Republic
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\n\nIntechOpen works with award winning print-houses and we hold to the fact that all of our printed products are of the highest quality.
\n\nIntechOpen books retail price range is:
\n\n100 - 159 GBP ex. VAT (available in USD and EUR)
\n\nDiscounts available:
\n\nBulk discounts are granted for orders of 10 copies and more.
\n\nThere is no minimum or maximum threshold on the quantity of book orders.
\n\nOrders have to be paid in advance and before printing. We accept payment in GBP, EUR and USD.
\n\nWe currently accept the following payment options:
\n\nWhen paying with a credit card, you will be redirected to the PayPal.com online payment portal.
\n\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\n\nIn accordance with the best security practice, we do not accept card orders via email.
\n\nThe combined printing and delivery time for orders vary from 7-15 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\n\nIf you do not receive your order within 30 days from the date your order is shipped, please contact us to inquire about the shipping status at orders@intechopen.com.
\n\nTax: Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.
\n\nCustoms: free shipping does not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\n\nP.O. Boxes cannot be used as a Ship-To Address.
\n\nIntechOpen partners do not provide shipping service from Europe to the countries listed below. Please refrain from mailing items addressed to the countries listed below, until further notice.
\n\nWhen ordering our books from the countries listed below, please provide an alternative mailing address. For any further assistance, please contact us at orders@intechopen.com.
\n\nRestricted Ship-to Countries:
\n\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us.
\n\nInspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\n\nPrint copies of our publications are most often purchased by universities, libraries, institutions and academia personnel, hence increasing the visibility and outreach of our authors' published work among science communities and institutions.
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\n\nMissing Link Versandbuchhandlung eG
\n\nRepresentative for: Germany, Austria, Switzerland
\n\nKuba Libri, s.r.o.
\n\nRepresentative for: Czech Republic
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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/74372",hash:"",query:{},params:{id:"74372"},fullPath:"/chapters/74372",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()