Associations of classic Hodgkin lymphoma with the measles virus.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7103",leadTitle:null,fullTitle:"Constipation",title:"Constipation",subtitle:null,reviewType:"peer-reviewed",abstract:"Constipation is a problem with multifactorial origin that affects both children and adults. It is a difficult problem to treat because there is no clear diagnostic criteria and there are only limited therapeutic options. This book presents information on constipation, including pathology, diagnosis, imaging, nutrition, and management, among other topics. It is written for physicians and interested readers alike.",isbn:"978-1-83881-873-9",printIsbn:"978-1-83881-872-2",pdfIsbn:"978-1-83881-874-6",doi:"10.5772/intechopen.73896",price:119,priceEur:129,priceUsd:155,slug:"constipation",numberOfPages:118,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"0f5c714417d2c8a2e536ff6f78302cea",bookSignature:"Gyula Mózsik",publishedDate:"October 2nd 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7103.jpg",numberOfDownloads:7393,numberOfWosCitations:3,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:8,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 26th 2018",dateEndSecondStepPublish:"September 4th 2018",dateEndThirdStepPublish:"November 3rd 2018",dateEndFourthStepPublish:"January 22nd 2019",dateEndFifthStepPublish:"March 23rd 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"24",totalChapterViews:"0",totalEditedBooks:"11",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"181",title:"Gastroenterology",slug:"gastroenterology"}],chapters:[{id:"65539",title:"Constipation",doi:"10.5772/intechopen.82392",slug:"constipation",totalDownloads:878,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Constipation is a common gastrointestinal (GI) disorder among all age groups. Constipation can be functional or pathological comprising of many etiologies. It can also be classified as acute or chronic; mild to severe. Although in most of the cases it is benign, symptoms can significantly affect the quality of life and cost-related burden for the patient. However, chances of late diagnosis of constipation are high due to a variety of etiologies and variable presentation. Most of the times, it is a great challenge for the clinician to find out the cause of constipation. Healthy lifestyle, especially keeping regular bowel habit, drinking adequate fluid, and the use of high-fiber diet that reduces the viscosity of stool, minimizes intestinal transit time and decreases the chance of constipation. Early diagnosis and management of other underlying factors are important to give relief to the patient from the undue physical and psychological stress.",signatures:"Tika Ram Bhandari and Sudha Shahi",downloadPdfUrl:"/chapter/pdf-download/65539",previewPdfUrl:"/chapter/pdf-preview/65539",authors:[{id:"270991",title:"Dr.",name:"Tika Ram",surname:"Bhandari",slug:"tika-ram-bhandari",fullName:"Tika Ram Bhandari"},{id:"271085",title:"Dr.",name:"Sudha",surname:"Shahi",slug:"sudha-shahi",fullName:"Sudha Shahi"}],corrections:null},{id:"65371",title:"Management of Pediatric Constipation",doi:"10.5772/intechopen.82855",slug:"management-of-pediatric-constipation",totalDownloads:867,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Constipation is a common problem in children. It accounts for 20–30% of pediatric outdoor office. It is common in both rich and poor countries despite the belief that developing countries consume food rich in fiber. Normal bowel movement in breastfed babies may range from several times a day to once in every 10 days. Constipation can be both functional and pathological. Functional constipation has no underlying cause and is the most common type of constipation found in children. My main focus will be on this common type of constipation. In functional constipation routine, digital rectal examination is not recommended unless impaction is suspected. Abdominal radiography is recommended only in equivocal clinical examination or if impaction is suspected and examination not conclusive. Dietary and behavior modifications, toilet training, and parent education are important in the management of functional constipation. Initial management of functional constipation includes disimpaction of stools. Lactulose is safe in all age groups. Polyethylene glycol is more effective than lactulose but is costly. Maintenance therapy may take some time till constipation improves. Some rare situations such as refractory and slow transient constipation are also discussed in this chapter.",signatures:"Raashid Hamid and Shazada Shahid Banday",downloadPdfUrl:"/chapter/pdf-download/65371",previewPdfUrl:"/chapter/pdf-preview/65371",authors:[{id:"213319",title:"Dr.",name:"Raashid",surname:"Hamid",slug:"raashid-hamid",fullName:"Raashid Hamid"},{id:"286547",title:"Dr.",name:"Shahid",surname:"Banday",slug:"shahid-banday",fullName:"Shahid Banday"}],corrections:null},{id:"63481",title:"Prevalence and Treatment of Constipation in Patients with Alpha-Synuclein Pathology",doi:"10.5772/intechopen.81010",slug:"prevalence-and-treatment-of-constipation-in-patients-with-alpha-synuclein-pathology",totalDownloads:1047,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"α-Synuclein “Lewy body” pathology is the basis of Parkinson’s disease (PD) and neurocognitive disorder with Lewy bodies (NCDLB), sometimes called Lewy body dementia. In patients with α-synuclein pathology, constipation, obstipation and impaction are almost universal symptoms, whose treatment represents a significant burden on health care economies. Description is given of the specific mechanisms through which α-synuclein pathology induces these symptoms, and through which the use of acetylcholinesterase inhibitors (AChEIs) might significantly reduce them. Four case studies are presented testing the hypothesis that the use of the cholinergic agonist donepezil might reduce the symptom of constipation in four patients with NCDLB or PD at different stages of disease progression. Outcomes are presented, as well as follow-up data at 6-, 12-, and 18-month intervals. The potential use of donepezil to reduce the symptoms of constipation in patients with α-synuclein pathology is discussed.",signatures:"Charles M. Lepkowsky",downloadPdfUrl:"/chapter/pdf-download/63481",previewPdfUrl:"/chapter/pdf-preview/63481",authors:[{id:"265794",title:"Dr.",name:"Charles",surname:"Lepkowsky",slug:"charles-lepkowsky",fullName:"Charles Lepkowsky"}],corrections:null},{id:"63827",title:"Imaging of Constipation and Its Complications",doi:"10.5772/intechopen.81472",slug:"imaging-of-constipation-and-its-complications",totalDownloads:1596,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Radiology is an important tool in the diagnosis and treatment of patients with constipation. Imaging provides both vital anatomic and functional information that may facilitate arriving at an accurate diagnosis, assessing for serious complications, and delivering the appropriate therapy in a timely fashion. In this chapter, we discuss how each imaging modality is used to image patients with constipation. Within this discussion, we review what information is provided by each modality and we detail complete imaging protocols and technical parameters for each test. Finally, we highlight key findings with illustrative images from radiography, fluoroscopy, CT, and MR imaging.",signatures:"Alexander S. Somwaru",downloadPdfUrl:"/chapter/pdf-download/63827",previewPdfUrl:"/chapter/pdf-preview/63827",authors:[{id:"265857",title:"M.D.",name:"Alexander",surname:"Somwaru",slug:"alexander-somwaru",fullName:"Alexander Somwaru"}],corrections:null},{id:"64330",title:"Therapeutic Role of Natural Products Containing Tannin for Treatment of Constipation",doi:"10.5772/intechopen.81837",slug:"therapeutic-role-of-natural-products-containing-tannin-for-treatment-of-constipation",totalDownloads:1574,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Many herbal plants and medicinal foods with laxative effects have been reported as novel therapeutic strategies for the treatment of constipation and its related diseases. Indeed, several natural products containing tannins exhibit remarkable laxative effects in a constipation model. Therefore, we reviewed the laxative effects and the mechanism of action of natural products containing tannins because tannins have a wide range of pharmacological activities against human diseases. These products improved the excretion parameters, histological structure, mucin secretion and the downstream signaling pathway of muscarinic acetylcholine receptors (mAChRs) in the constipation model. This review provides strong evidence that various medicinal plants containing tannins are important candidates for improving chronic constipation.",signatures:"Dae Youn Hwang",downloadPdfUrl:"/chapter/pdf-download/64330",previewPdfUrl:"/chapter/pdf-preview/64330",authors:[{id:"71831",title:"Prof.",name:"Daeyoun",surname:"Hwang",slug:"daeyoun-hwang",fullName:"Daeyoun Hwang"}],corrections:null},{id:"65080",title:"The Management of Constipation: Current Status and Future Prospects",doi:"10.5772/intechopen.83467",slug:"the-management-of-constipation-current-status-and-future-prospects",totalDownloads:1434,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Chronic constipation, a common condition, can have remarkably negative effects on a patient’s quality of life. Recent research has identified factors that may influence the prognosis of chronic constipation and suggests the need for adequate therapy. However, the major obstacles in this field were: (1) a small number of therapeutic options, (2) no clear diagnostic criteria, and (3) no effective method to collect information form the patients. These were due to the fact that bowel movement patterns vary widely among individuals, and also the functional constipation, including irritable bowel syndrome, is difficult to be distinguished from the chronic constipation. Recently, it has been demonstrated that the Rome IV diagnostic criteria of functional constipation and the Bristol stool form scale are useful for the objective evaluation and recording of stool. Based on these developments, and the increase of newly developed medicines the therapy for the constipation is significantly changing and therefore, if conventional therapy for chronic constipation is ineffective, switching of medicines is possible. Therefore, clinicians should update the information of these newly developed drugs available in clinics and diagnostic criteria. For this purpose, in this chapter, we have summarized the perspective on the current paradigm of treatment for chronic constipation focusing on recently introduced therapeutic drugs.",signatures:"Masaki Maruyama, Kenya Kamimura, Moeno Sugita, Nao Nakajima, Yoshifumi Takahashi, Osamu Isokawa and Shuji Terai",downloadPdfUrl:"/chapter/pdf-download/65080",previewPdfUrl:"/chapter/pdf-preview/65080",authors:[{id:"51900",title:"Dr.",name:"Kenya",surname:"Kamimura",slug:"kenya-kamimura",fullName:"Kenya Kamimura"},{id:"272130",title:"Dr.",name:"Masaki",surname:"Maruyama",slug:"masaki-maruyama",fullName:"Masaki Maruyama"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3317",title:"Current Topics in Gastritis",subtitle:"2012",isOpenForSubmission:!1,hash:"f771281e35f030a6438b269e736f910d",slug:"current-topics-in-gastritis-2012",bookSignature:"Gyula Mozsik",coverURL:"https://cdn.intechopen.com/books/images_new/3317.jpg",editedByType:"Edited by",editors:[{id:"58390",title:"Dr.",name:"Gyula",surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7943",title:"Nutrition in Health and Disease",subtitle:"Our Challenges Now and Forthcoming Time",isOpenForSubmission:!1,hash:"bf9135b4940c5e9bf0f7de103e543946",slug:"nutrition-in-health-and-disease-our-challenges-now-and-forthcoming-time",bookSignature:"Gyula Mózsik and Mária Figler",coverURL:"https://cdn.intechopen.com/books/images_new/7943.jpg",editedByType:"Edited by",editors:[{id:"58390",title:"Dr.",name:"Gyula",surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3860",title:"Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract",subtitle:"from Bench to Bedside",isOpenForSubmission:!1,hash:"62e71e4f81c52b92224c231016a34231",slug:"capsaicin-sensitive-neural-afferentation-and-the-gastrointestinal-tract-from-bench-to-bedside",bookSignature:"Gyula Mozsik, Omar M. 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Abdel- Salam and Koji Takeuchi",coverURL:"https://cdn.intechopen.com/books/images_new/3860.jpg",editedByType:"Edited by",editors:[{id:"58390",title:"Dr.",name:"Gyula",surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6810",title:"Capsaicin and its Human Therapeutic Development",subtitle:null,isOpenForSubmission:!1,hash:"9b0d5832824ac89f96d0557555448206",slug:"capsaicin-and-its-human-therapeutic-development",bookSignature:"Gyula Mozsik",coverURL:"https://cdn.intechopen.com/books/images_new/6810.jpg",editedByType:"Edited by",editors:[{id:"58390",title:"Dr.",name:"Gyula",surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5881",title:"Gastric 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Zhuang",slug:"jia-hsiang-zhuang",email:"abc0929352983@yahoo.com.tw",position:null,institution:{name:"National Tsing Hua University",institutionURL:null,country:{name:"Taiwan"}}},{id:"308021",title:"MSc.",name:"Shih-Wei",middleName:null,surname:"Su",fullName:"Shih-Wei Su",slug:"shih-wei-su",email:"nthu18356743@gmail.com",position:null,institution:{name:"National Tsing Hua University",institutionURL:null,country:{name:"Taiwan"}}}]}},chapter:{id:"68411",slug:"driving-control-technologies-of-new-high-efficient-motors",signatures:"Chang-Ming Liaw, Min-Ze Lu, Ping-Hong Jhou and Kuan-Yu Chou",dateSubmitted:"April 1st 2019",dateReviewed:"July 2nd 2019",datePrePublished:"August 22nd 2019",datePublished:"March 25th 2020",book:{id:"9290",title:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",subtitle:null,fullTitle:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",slug:"applied-electromechanical-devices-and-machines-for-electric-mobility-solutions",publishedDate:"March 25th 2020",bookSignature:"Adel El-Shahat and Mircea Ruba",coverURL:"https://cdn.intechopen.com/books/images_new/9290.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",middleName:null,surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"37616",title:"Prof.",name:"Chang-Ming",middleName:null,surname:"Liaw",fullName:"Chang-Ming Liaw",slug:"chang-ming-liaw",email:"cmliaw@ee.nthu.edu.tw",position:null,institution:null},{id:"180324",title:"Dr.",name:"Kai-Wei",middleName:null,surname:"Hu",fullName:"Kai-Wei Hu",slug:"kai-wei-hu",email:"kaiweihu@hotmail.com.tw",position:null,institution:{name:"National Tsing Hua University",institutionURL:null,country:{name:"Taiwan"}}},{id:"308019",title:"MSc.",name:"Jia-Hsiang",middleName:null,surname:"Zhuang",fullName:"Jia-Hsiang Zhuang",slug:"jia-hsiang-zhuang",email:"abc0929352983@yahoo.com.tw",position:null,institution:{name:"National Tsing Hua University",institutionURL:null,country:{name:"Taiwan"}}},{id:"308021",title:"MSc.",name:"Shih-Wei",middleName:null,surname:"Su",fullName:"Shih-Wei Su",slug:"shih-wei-su",email:"nthu18356743@gmail.com",position:null,institution:{name:"National Tsing Hua University",institutionURL:null,country:{name:"Taiwan"}}}]},book:{id:"9290",title:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",subtitle:null,fullTitle:"Applied Electromechanical Devices and Machines for Electric Mobility Solutions",slug:"applied-electromechanical-devices-and-machines-for-electric-mobility-solutions",publishedDate:"March 25th 2020",bookSignature:"Adel El-Shahat and Mircea Ruba",coverURL:"https://cdn.intechopen.com/books/images_new/9290.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193331",title:"Dr.",name:"Adel",middleName:null,surname:"El-Shahat",slug:"adel-el-shahat",fullName:"Adel El-Shahat"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11930",leadTitle:null,title:"Reliability-Based Design in Structure and Geotechnical Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThis book will discuss some key and significant parameters in the different Civil Engineering projects. The main contribution of some of the silent engineering parameters in both structure and geotechnical engineering will be comprehensively addressed. In order to undertake some statistical assessment, a comprehensive numerical simulation will be engaged in each chapter.
\r\n\r\n\tIn some structural engineering components, The linear buckling analysis will be simulated under different load combinations. It is determined the buckling load factor and corresponding mode shape of the structure under each given load combination case.
\r\n\r\n\tBesides, an accurate Finite Element technique to simulate the dynamic behavior of the composite steel-concrete beam systems under free and impulsive loading conditions will be developed. Different commercial Finite Element codes including ABAQUS/CAE and Strand 7 will be employed to suggest different approaches.
\r\n\r\n\tBased on the extensive statistical modeling, some practical equations will be suggested to provide more precise and reliable design equations in the current practice.
",isbn:"978-1-80355-103-6",printIsbn:"978-1-80355-102-9",pdfIsbn:"978-1-80355-104-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"63cb9ce2478d12b0649b47deaab8ab56",bookSignature:"Dr. Faham Tahmasebinia",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11930.jpg",keywords:"Numerical and Statistical Methods, Geotechnical Evaluation, Finite Element Analysis, Statistical Analysis, Failure Criterion, Dynamic Analysis, Soil Evaluation, Discrete Element Method, Analysis of Variance, Regression Analysis, Rock Bolt, Cable Bolt",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 20th 2022",dateEndSecondStepPublish:"June 24th 2022",dateEndThirdStepPublish:"August 23rd 2022",dateEndFourthStepPublish:"November 11th 2022",dateEndFifthStepPublish:"January 10th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"12 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Tahmasebinia obtained two Ph.D. degrees in Structural and Geotechnical Engineering, has over ten years of research experience, with nearly 80 research paper publications, and is a member of the Insitute of Civil Engineers.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"211659",title:"Dr.",name:"Faham",middleName:null,surname:"Tahmasebinia",slug:"faham-tahmasebinia",fullName:"Faham Tahmasebinia",profilePictureURL:"https://mts.intechopen.com/storage/users/211659/images/system/211659.jpg",biography:"Faham Tahmasebinia holds ME and ME-Research degrees in Civil/Structural Engineering from the University of Wollongong, Australia. He has also completed two Ph.D. degrees in the field of Structural Engineering at the University of Sydney, Australia and in the field of Rock Mechanics at the University of New South Wales, Australia. Currently, he is an academic at the University of Sydney. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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There are some questions, which need to be answered before making any plan for environmental sustainability. First of all, whether are we serious about protecting the natural resources of the world? Second, can we compromise on economic growth for the sake of environmental sustainability? After answering these two questions, governmental bodies can develop a master plan to address environmental issues effectively.
There is no doubt that the industrial revolution is a prominent cause of global warming and climate change. However, in reality, the problem is older than the industrial revolution. Besides, the industrial revolution only increased the speed of environmental degradation.
Environmental problems cannot be solved overnight. It will take time to restore and nourish environmental beauty through creating awareness in public, which will create indirect pressure on firms to produce eco-friendly products for the sake of their consumers’ demand [3, 4, 5]. There are many other pro-environmental policies, which can help to improve environmental sustainability. The critical factor, which plays a vital role, is governmental bodies’ willingness and seriousness to address the problem.
The consumption of fossil fuel and energy is not only fueling economic growth but also environmental problems. This is a primary cause why the environmental policies failed in the execution phase, and governmental bodies are unable to enforce it. According to Munir et al. [6], Economic growth and environmental sustainability have an inverse relationship. They also highlighted that economic growth is heavily based on the cost of environmental sustainability in developing nations. Wang and Zhu [7] argue that developed countries shifted their low-tech and labor-intensive manufacturing in developing nations, which is also a significant cause of social and environmental problems. Several researchers highlighted that China is a world-factory and fulfilling the demand of the European and Western world, while China’s social and environmental performance is the worst in the world [8, 9]. Similarly, India and other developing countries are blindly following China to improve their economic performance without catering to social and environmental issues facing the Chinese people and government [3, 6, 10, 11].
To address environmental problems without compromising economic growth, governmental bodies need to prepare a master plan, promoting eco-environmental sustainability. Following are some recommendations:
Technological advancement in manufacturing practices is highly recommended to reduce carbon emissions.
Adopting green practices in logistical and supply chain operations will help mitigate the harmful effect on environmental sustainability.
The continuous invention and innovation process renews the technological process that moves towards green development.
Provide loans to enterprises for green projects at low-interest rates.
Increase awareness of environmental issues in public, which will help to create demand for green products.
The green capital financing in agriculture food production may strengthen the agriculture industry, which will reduce the pressure on the environment.
Labor productivity may further be improved by providing eco-friendly training and awareness of environmental problems.
The financial and trade liberalization policies must be scrutinized in a serious node, as both are considered the critical determinants of globalization; thus, the tight environmental policies will effectively reduce carbon emissions and enhance environmental sustainability. Further, governmental bodies need to encourage firms for ISO certifications and eco-friendly practices through financial benefits.
Classic Hodgkin lymphoma (CHL) stands out among malignant tumors, by the relative paucity of the tumor cells in the involved lymph nodes. These Hodgkin and Reed-Sternberg (H/RS) cells (Figure 1) are distributed unevenly within the majority of inflammatory cells, fibrosis and necrosis [1]. It is understood that, independent of the proportion of H/RS cells in CHL, the outcome of the malignancy will be favorable, with a cure rate of 75–90% [2, 3]. Such a therapeutic success is unusual for cancer at large.
\nSection of lymph node from a patient with classic HL. Off center is a Hodgkin/Reed-Sternberg giant tumor cell (H&E × 360).
When considering the many prognostics and risk factors regarding CHL, the stage of the tumor, as expected, is the most relevant. Evidence of systemic symptoms: fever higher than 38°C for at least a month; weight loss of more than 10% of body weight, lasting 6 months or more, and/or drenching night sweats, singly or collectively, worsen the prognosis [1]. A difference is described between genders, as females fare as a rule better than males, no consideration being given to a higher incidence of nodular sclerosis CHL in females. Indeed, children and older adult males with mixed cellularity CHL, especially in developing countries, get on worse with the disease [2, 4]. In contrast, females would be included in the bulk of CHL patients, aged 15–36, with a favorable outcome [5].
\nSome 15-20% of human cancers are thought to arise by mechanisms which concern viruses, bacteria, or parasites [6, 7]. Evidence for their involvement comes partly from the detection of the microorganism in biopsies and partly from epidemiological and animal studies. Viruses might modify cellular genes directly, as with RNA tumor viruses, or may affect cell proliferation, as with DNA tumor viruses, and thus contribute to neoplasm formation [6, 7]. As a rule, the virus is responsible for only a limited number of steps in the promotion or progression of cancer. In most cases, the precise role of cancer-associated virus is hard to decipher, due to the long delay from the initial viral infection [6]. In any case, the number of human beings infected with the above viruses is much larger by far from that of patients who develop cancer. Therefore, tumor viruses probably act in conjunction with additional factors [7].
\nChronic inflammation may play an important role in the above processes as well as in other pathologic events which may lead to cancer [8]. In some cases of unresolved chronic inflammation, the immune response becomes maladaptive, hence promoting tumorigenesis [8]. A regenerative process supported by an array of bioactive mediators, promote cell survival, tissue remodeling, and angiogenesis. The mediators will also cause genomic stress and mutations [9].
\nA correlation between CHL and the Epstein-Barr virus (EBV) has been demonstrated many years ago [10, 11], with a causal relationship being established as soon as 2001 [12]. The incidence of EBV infection in CHL has shown a wide geographic variation, from 17 to 30% in industrialized countries, to as high as 100% in some developing countries [13, 14]. Several more years elapsed before the distribution of EBV infection by gender, age, and CHL type was determined (Figure 2) [13, 14]. Thus, EBV is expressed more frequently in males, notably in children from developing countries, as well as in older adults all over the globe, these two groups showing as a rule mixed cellularity CHL. Female CHL patients stand out, in general, by showing nodular sclerosis CHL with a markedly lower level of EBV expression and a young adult age (15–36) [15]. A small subset of young adult males will develop CHL after recovering from infectious mononucleosis [16]. The EBV is recognized as oncogenic. Specifically, its transforming potential, with cell proliferation, inflammation, and apoptosis arrest, has been related to the nuclear factor-κB (NF-κB) and the EBV/LMP1 will further contribute to the inhibition of the H/RS cell apoptosis [15, 16, 17, 18, 19]. As noted, EBV does not play a significant role in the largest subset of CHL that affect young adults and most of the female CHL patients.
\nAssociation between age, gender, EBV expression, and classic Hodgkin lymphoma, including the types thereof.
The above subset of young adult female patients corresponds to that defined in the hallmark epidemiological studies in the early 1980s as patients with the “late host response model” [15, 16, 17, 18, 19]. These patients are considered to be submitted to the late exposure to a common infectious agent, the term “late” meaning that instead of coming across the common infectious agent for the first time in early childhood, this occurs at adolescence or young adulthood. The epidemiological thesis further suggests that these individuals had a late encounter with the agent, since they had few and late contacts with other children (single child, individual family house, and child who skipped the kindergarten) [15]. To account for the late host response model, it is suggested that a common agent, probably a virus, reaches the organism for the first time at a stage in which the metabolism and/or the hormonal balance is markedly different from that of a toddler, the age at which the encounter regularly takes place. At this point, the internal environment has varied deeply and probably, so has the immune system [15, 16, 17, 18, 19]. Thus, it seems that the EBV plays a relatively minor role, in the largest subset of the CHL that is most prevalent in industrialized countries [18].
\nWhen looking for a substitute for the EBV in CHL, it was observed that none of the additional viruses, HHV-6, -7, -8, polyoma JC virus, SV40, HTLV-1 and -2, and human retrovirus 5, once considered as possible candidates, have been detected in CHL tissues [20, 21, 22, 23, 24, 25, 26]. The only virus to be incompletely excluded at that time was the HCMV. However, one distinct virus showed qualities and associations which recalled to various extents of those of CHL.
\nThe “candidate” proposed by us is the measles virus (MV). It penetrates the organism through the oropharynx. But, since it is lymphotropic, it enters the adjacent lymphoid tissues. This may account for the vast majority of CHL starting in cervical and/or in mediastinal lymph nodes [12, 27]. Histologically, it elaborates multinucleated cells—the Warthin-Finkeldey polykaryons. Of note, these polykaryons differ largely from the H/RS cells of CHL, mainly by the number of nuclei (up to 70) as well as by their phenotype (they are T-lymphocytes) [28]. An acute measles infection is soon followed, on the one hand by a life-long specific immunity, but also, paradoxically a transient cellular immune deficiency systematically develops. This deficiency lasts about 6 months, but at times, may last longer. The cellular immune deficiency which affects CHL patients is not different in principle, but it may be long lasting [12].
\nClassic Hodgkin lymphoma-nucleoprotein-MV expression. a. Positive cytoplasmic immunostain of Hodgkin/Reed-Sternberg cells. b. Immunostaining following neutralization of antibody with a relevant MV peptide (Immunoperoxidase with DAB × 320).
At the time our thesis was formulated, the type of MV neural infection known as subacute sclerosing panencephalitis (SSPE) was considered one of the very few persistent MV infections, most being CNS slow viral infections. However, it was difficult to grasp a possible association between MV and cancer, which would not account for the long lapse of time necessary for the malignant transformation. In that context, the absence of a persistent MV infection might be counterproductive. The alternative being that against all odds, MV may be oncogenic, and the MV is not among the consensually recognized oncogenic viruses! An additional clue to MV causing a persistent infection beyond the CNS is the absence of membrane expression of hemagglutinin MV antigens, although this lack of expression might be due also to the lymph node mode of fixation [29].
\nThe basic part of our study (2003–2004) concerned 154 patients with CHL diagnosed between 1975 and 2000 at the Soroka University Medical Centre in Beer-Sheva, Israel, whose tissues were available for research. Only pretreatment biopsies with confirmed histological type, by two hematopathologists were included. Clinical data were retrieved from the patients’ charts and when those were not found, the details were searched in the Israel Population Registry by linkage.
\nImmunophenotyping was performed on formalin-fixed, paraffin-embedded (FFPE) tissues by the avidin-biotin peroxidase complex method and the Vectastain kit by Vector Laboratories (Burlingame, CA, USA) as described. The EBV/LMP1 antibody was purchased from Dako (Glostrup, Denmark); the anti-MV antibodies were either commercial: anti-nucleoprotein (NP)-MV; anti-hemagglutinin (HA)-MV; anti-matrix (M)-MV; and anti-phosphoprotein (P)-MV were purchased from Chemicon International Inc. (Temecula, CA, USA). Further experimental antibodies were a gift from Birrer et al. [30]: anti-NP, H14; and from Schneider-Schaulies et al. [31]: anti-NP, L39/22; L39/61 or anti-HA antibodies, K83; L77. The antibody specificity had been demonstrated by Western blotting. The staining was considered positive if 10% of H/RS cells or more were positive. For stringency purposes, we requested positivity for two MV antigens, for a case to be considered positive. A murine neuroblastoma cell line permanently infected by MV was used as a positive control; the same cell line, but non-infected was used as a negative control. These cell lines were also the controls used for the RT-PCR and ISH assays. Twenty-five cases of non-Hodgkin lymphoma were also tested by IHC.
\nTotal RNA was obtained by extraction of snap-frozen lymph node samples from part of our patients, when available. For this goal, EZ-RNA Total RNA Isolation Kit (Biological Industries Co., Beit Ha-Emek, Israel) was employed, using the manufacturer’s instructions. To each sample, 40 U of RNA-guard (Promega, Madison, WI, USA) were added. One step RT-PCR was performed with Ready To Go ™ RT-PCR beads (Amersham Pharmacia Biotech Europe GbmH, Freiburg, Germany). A measure of 3 μl of RNA (2-6 μg) was used for each reaction. For the primers used in this study, see Table 1 from Ref. [3]. Nested PCR was carried out, using SUPER-NOVA DNA polymerase (Roche Molecular Biochemicals, Mannheim, Germany).
\nTotal RNA was also retrieved from several FFPE tissues from CHL patients, using the Paraffin Block RNA Isolation Kit (Ambion Inc., The RNA Company, Austin, TX. USA) and RT-PCR followed by nested PCR carried out with 10 μl RNA, as described above. As controls, we used seven cases of non-Hodgkin lymphomas, one CHL which was negative for MV by IHC. As housekeeping genes, we used β-actin and protein phosphatase 2C β (pp2Cβ) considered appropriate for experiments related with low amounts of RNA.
\nTo confirm our RT-PCR findings, the cDNA products of the nested PCR were blotted to GeneScreen (NEN Research Products, Boston, MA, USA) and hybridized to either an NP-MV probe (
The digoxigenin (DIG)-labeled antisense and sense probes to MV-specific mRNAs were prepared by linearizing the plasmids containing NP-MV including positions 105–586, and those including HA-MV encompassing positions 8147–8482 in PGEM-T Easy Vectors (Promega), with
This was performed on a sampling of cases. For this purpose, IHC positivity to a single NP-MV or HA-MV antibody was considered sufficient.
\nEmphasis was given to MV IHC and to EBV-LMP1 expression, as RT-PCR and ISH disclosed much less results. For contingency table analysis, the χ2 or Fisher’s exact test was used as appropriate.
\nThe lymph node tissues of 82 of 154 CHL patients were positive for at least two MV antigens (Figure 3). Neutralization of immunostaining was made possible by incubation of the primary anti-NP-MV antibody with the corresponding NP-MV peptide (Figure 3b). This assay confirms the specificity of the anti-NP-MV antibody in this context. Twenty-five cases of non-Hodgkin lymphoma (NHL) were totally negative for MV antigens.
\nA Southern blotting of the nested PCR shows several bands, some stronger, others faint, disclosing more hemagglutinin (HA, H) MV positivity, as compared with NP-MV positivity (Figure 4). Samples from 7 NHL were negative. Thus, in our laboratory, HA-MV RNA was positive in 4 of 15 cases, while only 2 of 16 NP-MV RNAs were expressed by the Southern blot in CHL.
\nSouthern blotting based on cDNA from RT-PCR: A. A few cases of CHL show bands positive for hemagglutinin-MV (PC—positive control). B. Isolated bands, positive for nucleoprotein-MV. C and D. Absence of expression of MV in non-Hodgkin lymphomas.
Upon sequencing and alignment of three of the experiment products, we displayed an almost complete homology with the control (see [3] for details on the homology).
\n\n
\n
A clinicopathological correlation was based on the immunophenotypic findings, as the specificity of the antibodies had been sustained by Western blotting and since, in each case, the immunostain had been confirmed with more than two antibodies. Last, the immunohistochemical (IHC) study had released the most manageable results.
\n\nTable 1 shows a statistically significant expression of MV antigens in female patients, in nodular sclerosis (NS) CHL, as compared with mixed cellularity (MC) CHL. A significant correlation was exhibited between negative CD15 and p53, and the negative expression of MV. Table 2 displays a statistically significant expression of MV antigens compounded by the expression of EBV/LMP1, in NS-CHL, significantly more than that in MC-CHL, in early clinical stages, with apoptotic index lower than median and with the positive expression of MDM2.
\n\n | MV+ | \nMV− | \n\n | \n|
---|---|---|---|---|
n (%) | \nn (%) | \n\n | ||
Total | \n\n | 82 (54.3) | \n69 (45.7) | \n|
Gender | \nF | \n40 ( | \n28 (35.5) | \n0.036 | \n
M | \n42 (47.2) | \n47 (52.8) | \n||
Subtype | \nNS | \n58 ( | \n27 (31.8) | \n0.0013 | \n
MC | \n21 (40.4) | \n31 (59.6) | \n||
CD15 | \npos | \n77 (59.7) | \n52 (40.3) | \n0.015 | \n
neg | \n4 (26.7) | \n11 ( | \n||
p53 | \npos | \n72 (61.5) | \n45 (38.5) | \n0.017 | \n
neg | \n5 (31.3) | \n11 ( | \n
Associations of classic Hodgkin lymphoma with the measles virus.
\n | MV+; LMP− | \nMV−; LMP+ | \n\n | \n|
---|---|---|---|---|
Subtype | \nNS | \n45 ( | \n7 (13.5) | \n0.00008 | \n
MC | \n11 (44) | \n14 (56) | \n||
Stage | \nI–IIA | \n22 ( | \n4 (15.4) | \n0.023 | \n
IIB–IVB | \n22 (57.9) | \n16 (42.1) | \n||
BCL-2 | \nPos. | \n31 ( | \n2 (6.1) | \n0.0001 | \n
Neg. | \n27 (54) | \n23 (46) | \n||
MDM-2 | \nPos. | \n36 ( | \n5 (12.2) | \n0.0013 | \n
Neg. | \n18 (54.5) | \n15 (45.5) | \n||
Apop index | \n<Median | \n31 ( | \n7 (18.4) | \n0.024 | \n
>Median | \n22 (42.1) | \n16 (57.9) | \n
Hodgkin lymphoma—association with measles and Epstein-Barr viruses.
A multivariable logistic regression model of the association of prognostic factors with dying from CHL, in 89 patients, is shown. Stage IV, as compared with the remainder, carried a significantly poorer prognosis, thus confirming that our cohort was representative. The compound expression of MV and EBV, specifically of MV+; EBV−, as well as MV−; EBV− was displayed as poor risk factors in our patients (Table 3).
\nFactor | \nOdds ratio | \n95% CI | \n\n | \n
---|---|---|---|
Gender | \n1.32 | \n0.34–5.18 | \n0.69 | \n
Stage | \n2.3–80.5 | \n0.004 | \n|
Bcl-2 | \n0.34 | \n0.08–1.44 | \n0.34 | \n
MV+; EBV− | \n0.98–103.47 | \n0.05 | \n|
MV−; EBV+ | \n1.53 | \n0.07–35.44 | \n0.79 | \n
MV−; EBV− | \n1.05–220.3 | \n0.04 | \n
Multivariable logistic regression model of association of prognostic factors with dying of HL in 89 patients.
The results of the first part of our study (2004) are summarized [3]. The association between MV and CHL, in a descriptive investigation, does not contain, so far, causal elements. This linkage is sustained by older epidemiologic studies describing brain and spinal cord tumors, as well as CHL, which followed exposure to the MV around the time of birth [33, 34]. They also suggest sporadic cases of CHL regression, occurring after acute measles infection or an MV vaccine [35, 36, 37, 38]. Moreover, viral childhood infections, including measles, have been reported to protect from CHL occurrence [39].
\nEarly clinical correlations exhibit more females, more NS-CHL, and more early stage cases, among patients with positive MV expression in their lymph node tissues. Nevertheless, positive MV expression in CHL seems to be related with a worse prognosis. One cannot refute the loss of the advantage conferred to the above variables by an MV infection, as expressed in the H/RS cells of CHL. Any mechanism involving the MV in CHL, if uncovered, should correlate with a worse outcome of the malignancy.
\nTwo years following the publication of the above-mentioned article and several months after the presentation of a poster at the Hodgkin Lymphoma Meeting in Kiel, a scientist, from Germany, contacted me indirectly, informing me that he wanted to investigate our findings. He proposed to find out whether he could reproduce our data in his lab. He also requested to make any fresh-frozen CHL tissues available to him, mainly those which showed an MV-antigen positivity.
\nIn their labs, the German scientists had collected 44 frozen CHL samples, of which, only 18 were selected for their high quality RNA, as determined by the Agilent technology, as well as for classic H/RS cell morphology. Using UV-laser beam single cell microdissection, some 100 H/RS cells were pooled for each experiment. Total RNA was extracted and RT-PCR was performed with primers from three MV genes, which were different from those we had used in Israel [40].
\nFive CHL-derived cell lines were found to be negative for the three MV transcripts. Moreover, the 18 selected German cases did not show, either, evidence of any of the three viral transcripts. The GAPDH gene, used as a housekeeper gene for these experiments, displayed a large amount of RNA. At this point, the German group had received the 22 snap-frozen CHL samples from our laboratory. The cases had been chosen, as requested for their positive MV antigens, as shown on FFPE tissues. However, the selection highlighted only 7 of these cases, chosen for the high RNA quality and the classic H/RS cell features [40].
\nAll 25 RNA samples disclosed negative results with the three MV transcripts, as studied in Essen labs. Back to Israel, 5 of 12 German histological unstained slides, subjected to IHC, were found to express MV antigens in the H/RS cells. A similar discrepancy in favor of IHC was also obtained in our series (Table 4).
\n\n | NP-MV | \nHA-MV | \n||
---|---|---|---|---|
\n | Positive/n | \n(%) | \nPositive/n | \n(%) | \n
RT-PCR | \n1/16 | \n(6.25) | \n7/21 | \n(33.3) | \n
ISH | \n7/14 | \n(50) | \n4/7 | \n(57.1) | \n
IHC | \n25/29 | \n(86.2) | \n20/29 | \n(68.9) | \n
Comparison of results obtained by three assays.
NP, nucleoprotein; HA, hemagglutinin; MV, measles virus; RT-PCR, reverse transcriptase-polymerase chain reaction; ISH, in situ hybridization; and IHC, immunohistochemistry.
The German scientists invited one of my colleagues and myself to co-author their manuscript. At every stage, we were reluctant to accept the invitation, due to the concern for a permanent damage to our hypothesis. Moreover, we did not curb our criticism, which covered several aspects of the manuscript. Prominent among these was the tight selection of the cases (both those from Germany and Israel). The methods used in Essen differed markedly from ours, notably the single cell microdissection, a different strategy for the RT-PCR and the choice of primers. Following our criticism, minor changes were introduced, but the German group did not go all the way: “….due to their worry that the manuscript will lose its sharp edge and might not be accepted by a highly rated journal.”
\nThe Scott collaborators of the Essen scientists reported above selected a group of patients, many of whom having suffered from measles, mainly as children. We consider this selection as counterproductive, since these patients should have been protected from the development of CHL. The very fact that they were not refutes the prevalent thesis that exposure of a child, aged 1–4 years, to MV infection protects the subject from CHL at a young-adult age [41]. The Scottish group may have had their own agenda, which might have unsettled the question raised by us. In addition, the antibody used by the Scott group is problematic: the clone 49–41 was purchased by us from Argene-Biosoft, Varilhes, France (# 11-045). It was not an anti-nucleoprotein antibody, as stated, and was positive in our lab for 37 of our 72 CHL cases (data not shown). Moreover, not unlike the German scientists, the Scotts used the GAPDH gene as a housekeeping gene, and we have already mentioned why it was not appropriate.
\nI have to admit, that we not only considered ourselves as the minor partner, but that we were such indeed! We had been recurrently reassured by the German scientists and by then had our two names included in the manuscript as co-authors. However, when we read the finalized doublet articles (in addition, the article by Wilson et al., weighted heavily on the balance) [41], published in the International Journal of Cancer, we realized that we had made a huge mistake.
\nThe days which followed the double publication were crucial, since we were not sure, as co-authors, whether we were entitled to carry out an “insider” censure. When we read the final paper, we grasped the experience in terms of a possible deception. In addition to the impediments mentioned above, we also noted that the housekeeping gene, the GAPDH, might not be an adequate choice at all, since we had shown that CHL is most probably of low MV-RNA abundance. In contrast, the Essen group had described in relation with GAPDH a large amount of RNA [40]. Moreover, of the seven Israeli cases, selected for the experiment in Germany, five had been shown by us to present a faint MV-RNA positivity only (two) or were negative (three).
\nAn independent putative evidence for a role of the MV in carcinogenesis is that part of the MV proteins that interacts with and stabilizes the Pirh2 protein, an ubiquitin E3 ligase, by preventing its ubiquitination. Pirh2 indeed negatively regulates p53 by targeting it for degradation in the proteasome.
\nAltogether, our criticism of the article, in which we took officially a part, is in principle that the German scientists carried out an investigation, which was by their declared intention, a duplication of our own research [3]. However, their study was anything, except a duplicate of ours! It stands out independently, with major flaws, notably a very strong selection of cases, the use of questionable primers of a housekeeping gene which is not appropriate for the expected amount of retrieved MV-RNA. It is of note that when confronted with our criticism regarding the manuscript, the German group seemed to agree, but did not modify the manuscript: “…for fear of weakening our data”. Moreover, they insisted on mentioning the relevance of the findings to the CHL pathogenesis, which was not appropriate at this stage nor was it agreed upon [40]!
\nAt this point, we insist that the impact of the European group refutation, on a possible role of MV in CHL, was extremely ruinous to our position and thesis. Moreover, its repercussions are felt to this day: for the reasons mentioned above, not a single investigator has accepted to engage in this project anymore, together with us or independently. By so doing, the two research groups have categorically “buried” our hypothesis. At the same time, we felt a release from the constraints which might have led us freeze in our position and we allowed ourselves again to indulge in the research concerning the measles virus and cancer. Therefore, we first wrote a review on our experience, as described above [42, 43].
\nWe set out to delve into endometrial carcinoma (EC), looking for the footprints of the MV in this cancer. Our cohort of EC included 49 patients, 36 of whom had a known follow-up. Using IHC and several anti-MV antibodies, we disclosed that 26 of the 36 (72%) did express MV antigens in tumor cells, mainly in type I EC (Figure 6). In addition, 16/21 of the patients displayed positivity for MV-RNA by ISH. When type II EC was allied with MV, then deeper myometrial invasion and a higher mortality were evident [44].
\nEndometrial carcinoma—MV expression in tumor cells and in normal endometrium. a. Cytoplasmic HA-MV antigen is positive. b. Positive immunostain for NP-MV antigen. c. ISH positivity for NP-MV in tumoral glands. d. ISH positivity of surface and glandular normal epithelium of the case shown in c.
Our next endeavor concerned the possible role of MV in lung cancer. Our interest was first raised by the probable relevance of Pirh2 in lung cancer. Indeed, Pirh2, an E3 ubiquitin ligase, was found to be expressed in lung cancer, in which it inhibits p53 [45]. It was later found that the P-protein of the MV inhibited the function of Pirh2 (see description in [48]). This indirect association between lung cancer, Pirh2 and p53, and MV led us to the following study. We identified 65 non-small cell lung cancers, for which FFPE tissues were available over 10 years. We limited our study to the IHC analysis with several anti-MV antibodies (Figure 7). Of the cases included, 54/65 were positive for MV antigens. These 54 positive cases were associated with older patient age, with positive Pirh2 expression, as well as with an improved survival [46].
\nLung cancer—positive for MV. a. Adenocarcinoma. b. Squamous cell carcinoma (IHC with DAB × 240).
The following study concerned breast cancer and the MV-IHC expression. We identified 131 breast cancer cases, with preserved FFPE tissues. Of these cases, 64% were positive for the MV antigens (Figure 8). Positive MV expression was associated with ER (
Breast cancer is positive for measles virus antigens. a and c. Negative controls. b and d. Positive immunostains (immunoperoxidase with DAB × 180).
Variable | \nVariable distribution | \n|
---|---|---|
\n | \n | |
Age | \n<50 years | \n>50 years | \n
Ethnicity | \nJewish | \nBedouin-Arab | \n
Birth place | \nIsrael/Europe/America | \nAsia/Africa | \n
\n | \n | |
Tumor diameter | \n<10 mm | \n>10 mm | \n
Axillary LNs | \nNone | \nInvolvement | \n
DCIS component | \nYes | \nNo | \n
Grade | \nLow/intermediate G1–2 | \nHigh G3 | \n
\n | \n | |
ER | \nPositive | \nNegative | \n
PR | \nPositive | \nNegative | \n
HER2 | \nPositive | \nNegative | \n
Ki67 | \nPositive | \nNegative | \n
p53 | \nPositive | \nNegative | \n
NP-MV | \nPositive | \nNegative | \n
HA-MV | \nPositive | \nNegative | \n
Distribution of demographics, clinics, pathology, and MV expression in breast cancer patients.
We have speculated whether the MV phosphoprotein, through its relation with the Pirh2, ubiquitin ligase, by itself negatively related with the p53 expression, may have more relevance,
Pathology | \nPositive (%) | \nNegative (%) | \n
---|---|---|
Adenocarcinoma | \n11 (84.6%) | \n2 (15.4%) | \n
Squamous cell carcinoma | \n3 (100%) | \n0 | \n
Large cell carcinoma | \n1 (100%) | \n0 | \n
Bronchioloalveolar carcinoma | \n1 (100%) | \n0 | \n
Western blotting using a phosphoprotein-MV antibody.
Western blotting with an antiphosphoprotein-MV antibody on fresh frozen tissues of non-small cell lung cancer. Most cases show positive expression both in tumor tissue (T) and in nonadjacent nonneoplastic lung tissue (H). In a few cases, the MV expression is found in the tumor only.
\n | Positive staining % | \nNegative staining % | \n||||
---|---|---|---|---|---|---|
Organ | \nNucleus | \nCytoplasm | \nStroma | \nNucleus | \nCytoplasm | \nStroma | \n
Lung | \n10 (52.6%) | \n2 (11.1%) | \n0 | \n9 (47.4%) | \n16 (88.9%) | \n18 (100%) | \n
Colon | \n13 (68.4%) | \n7 (36.8%) | \n4 (23.5%) | \n6 (31.6%) | \n12 (63.2%) | \n13 (76.5%) | \n
Stomach | \n14 (73.7%) | \n4 (21%) | \n0 | \n5 (26.3%) | \n15 (79%) | \n19 (100%) | \n
Breast | \n15 (75%) | \n10 (50%) | \n2 (10%) | \n5 (25%) | \n10 (50%) | \n18 (90%) | \n
Tissue microarray using a phosphoprotein-MV antibody.
Our experience with melanoma and benign melanocytic nevi is shown in Table 8. The table shows the expression of several MV antigens and of Pirh2. The expression of NP-MV is the strongest and resembles that of Pirh2. A similar trend, but with a more limited expression, is found in benign melanocytic nevi. It is of note that the expression of the P-protein in melanomas is the mirror image of that of the NP-MV antigen. This was a preliminary exercise and no follow-up is yet available. The positivity of 23 benign nevi for NP-MV should be investigated to exclude evidence of a pre-malignant condition.
\nAntigen | \nLevel | \nMelanoma | \nBenign nevi | \nP value | \n
---|---|---|---|---|
NP-MV | \nPos. | \n46 | \n23 | \n\n |
\n | Neg. | \n10 | \n1 | \n0.16 | \n
P-protein | \nPos. | \n19 | \n10 | \n\n |
\n | Neg. | \n36 | \n12 | \n0.37 | \n
HA-MV | \nPos. | \n19 | \n7 | \n\n |
\n | Neg. | \n3 | \n1 | \n1.00 | \n
Pirh-2 | \nPos. | \n44 | \n19 | \n\n |
\n | Neg. | \n12 | \n6 | \n0.79 | \n
Melanoma and measles virus.
At this stage, we were motivated to determine whether some categories of tumors might be uniformly negative for MV antigens. One limitation is that these tumors were often showed with a restricted sampling. In our original study, we included 25 NHLs by IHC and 7 cases of non-Hodgkin lymphoma by RT-PCR. They were all negative for MV. Only later did we find an interest in ALK-positive anaplastic large cell lymphomas in this regard. In contrast, these lymphomas were predominantly positive for MV. A large scale study of seminomas showed negativity for the MV antigens. Glioblastomas and mesotheliomas were negative for the antigens (Samuel Ariad, personal communication). I later examined small samples of the following tumors which were also negative for the MV antigen: Merkel-cell tumors, hepatocellular carcinoma, malignant mixed mesodermal tumors, and desmoid tumor.
\nIn 2010, we revised and expanded a prior study on the role of apoptosis in CHL [50, 51]. This was undertaken in the light of a consensual point of view: it has been stated that apoptosis in CHL is arrested; this is carried out not only with the help of the NF-κB machinery but also through the expression of EBV-LMP1 that inhibits apoptosis [52, 53, 54, 55]. The consensus further determines that this apoptosis hindrance is necessary, since tumor cells in CHL are B cells which cannot express the B-cell receptor (in physiologic conditions, such cells have a strong tendency to die in apoptosis). Thus, apoptosis inhibition is a pre-condition for the survival of H/RS cells [56]. However, in our revision, we found inhibition of H/RS cells apoptosis in 55% of the 217 cases only. Our findings also suggested that NF-κB, specifically the p65 protein, as well as EBV/LMP1 expression did not correlate with apoptosis arrest, in contrast with the consensus view [57]. Of note, it has been shown that although the presence of canonical NF-κB has been considered to be implied, it is the noncanonical NF-κB, which is of predominant relevance in CHL [51]. In the revision we have shown that the most significant association of H/RS cell apoptosis was with p53, the negative expression of which was related with a high apoptotic index (
In contrast with the classic measles infection, the atypical measles syndrome occurs in older patients, often presenting with a heterogeneous rash, pulmonary infiltrates, hepatic dysfunction, and eosinophilia. The formation of immune complexes has been proposed as responsible for the manifestations of the syndrome [58]. This self-limiting disease, may show, however, long lasting, asymptomatic pulmonary nodules. An immune waning is suspected to occur in this disorder, though such an event has been refuted with measles virus infection at large. Officially, patients with this syndrome have been reported as recently as 2015 [59].
\nThe atypical measles syndrome (AMS) stands out when compared with classic measles for the following reasons.
\nAMS presents at an older age, often with a high and prolonged fever. A polymorphic rash starts in the hands and feet. In the lungs, this disorder shows nodular infiltrates together with swollen hilar lymph nodes. These changes may regress suddenly. Liver function tests are often abnormal in AMS. Eosinophilia is frequent. This disease entity was first described in 1963, following the vaccination with the formalin inactivated measles virus (FIMV) vaccine. A subsequent exposure to the wild type MV has often been identified. The FIMV vaccine is said to have been withdrawn in 1967, but new cases of AMS were still reported in 2015 [59].
\nClinically, the AMS does not resemble the classic MV disease and is usually mild. GPs have difficulties in making the diagnosis in real time. Anti-MV antibody titers are higher than 1:160, which is very unusual for classic measles. In AMS, Koplik spots are frequent and mostly will last 5–7 days, while they last rarely more than 2 days in the classic disease. Photophobia is rarely present in AMS. AMS is probably not contagious [60].
\nWhile most cases of AMS in the 1960s were associated with FIMV, the more recent occurrences have been associated with the live attenuated measles vaccine (LAV). Vaccination with FIMV had offered protection for a few months, after which the titers dropped suddenly [61]. We have suggested that this drop of antibody titers is most consistent with a humoral immunity waning. Cases of AMS with prior LAV vaccine have been reported, which are consistent with secondary vaccine failure. Such cases have been suggested to follow a prolonged exposure to an acute measles patient [62].
\nTo confirm the ease by which the diagnosis of AMS is missed, 291 recruits were diagnosed with measles in 1987. They were young adults, with abdominal pain, diarrhea, and vomiting (33%); Koplik spots lasting a mean 7 days; and abnormal liver function tests (86%). The diagnosis of AMS was missed. Retrospectively, this was most certainly the diagnosis, although no anti-MV titers have been reported [63].
\nIn 2015, Levine et al. reported on the status of the measles immunity, 20 years after the two-dose MMR vaccine was introduced. Of the cohort of recruits in 1996, 95.6% had shown positive anti-MV antibodies. In 2007, this positive data had dropped to 85%. Although the authors did not dare to make the statement, this reflected a state of waning immunity, to our opinion [64].
\nTo summarize this issue, we have showed that the AMS differs from typical measles by various features. This is probably a disorder of immunologic nature, involving immune complexes. The AMS is presently rare, but to our opinion, this may be due to a notable under-diagnosis. The association between the AMS pathogenesis and immune waning should be confirmed. It is not excluded that this disorder be related with carcinogenesis as well [65, 66], as it has been proposed that a persistent viral infection is required for virus-associated carcinogenesis [67] and that a waning immunity might lead to a persistent MV infection.
\nA relationship between MV expression and CHL was provisionally established on IHC [positive with two antigens or more in 82 of 154 CHL patients]; on RT-PCR [positive in 4 of 15 cases for HA-MV RNA; for 2 of 16 NP-MV RNA], and on
A clinicopathological correlation, based on the IHC results, was chosen, mainly due to the frequent results as compared with RT-PCR and
Regarding the refutation of our findings and conclusions by the German group, this might have been an occasion for further learning. However, the repercussions thereof, on our thesis and our findings, were such that no future was available for us in this domain. As a colleague described it, our position and our theory had been buried. Moreover, I never understood why it was done in that most unpleasant way.
\nA chapter on the atypical measles syndrome was introduced at the end of the study. This disorder is related with measles and with the MV, but the link has not been clarified completely. Most of the AMS features, clinical, radiological, and biological, differ completely from those of measles. While measles is predominantly an infectious disease, and is highly contagious, AMS is probably not contagious, with its pathogenesis probably based on the formation of immune complexes. One of the highlights of the AMS is an anti-measles antibody titer of 1:160 or higher, much beyond that found in measles. Our interest, at this point, laid in evidence pointing toward immunity waning, as an essential component of AMS. Moreover, in the presence of a sharp drop in the titer, following mainly the FIMV vaccination, as well as occasionally that of the LAV vaccine, the subject might be submitted to the protracted exposition to an acute measles patient. So far, we are not aware of cancer developing in the context of AMS cases, but, since this disorder is often missed, it might be worthwhile looking for cases of cancer within such a context [60].
\nThe prospects and suggestions for proceeding with our research include an epidemiologic study as well as the duplication of our basic investigation, but this once by scientists of good faith. The epidemiologic investigation should have 3 components: the first two, based on our CHL cohort, about half of which show IHC evidence of the MV. Of this population, we will attempt to identify, via the Israeli Ministry of Health Registry, patients who had contracted measles as well as those who had been vaccinated for MV, including vaccination details. The third will deal with AMS, based on the cohorts highlighted by Giladi M et al. [63], and Levine H et al. [64]. Confirmation in the first of the diagnosis of AMS, and research of patients with possibly MV-related tumors and in the second, confirmation of the relevance to immune waning.
\nWe thank Kibbutz Sde-Boker for their support.
\nThe author declares no conflict of interest.
Many warm thanks : Samuel Ariad, Martin Sacks, Yonat Shemer-Avni, Yi-Yi Myint, Bracha Rager, Irena Klinkovich, Jacob Gopes, and Eugenia Mejirovski for their valuable contribution.
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\n\nAt this step you will also be asked to accept the Copyright Agreement.
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\n\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
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\n\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n6. INVOICE PAYMENT
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\n\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
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Often in the implementation practice of companies’ social responsibility, there can be attention focus on one or even several very significant activities, which indicated that the organization has not yet assimilated the valuable content of this idea and is developing its activity by ignoring a very important principle of inner maturity.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"59034",title:"Structure of Research Design: Expert Evaluation",slug:"structure-of-research-design-expert-evaluation",totalDownloads:1136,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"This chapter presents the research design/plan. Methodological choice of quantitative and qualitative research is substantiated, and principles of design and verification of the research instrument are described. Individual stages of the research are presented in detail by describing their consistency in respect of the main objective. Statistical calculations to substantiate the reliability of the research instrument are presented and key aspects of the organization of research are described.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"59158",title:"Professional Social Responsibility in Engineering",slug:"professional-social-responsibility-in-engineering",totalDownloads:2853,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"This chapter presents a range of viewpoints on the social responsibilities of the engineering profession. These social responsibilities of the engineering profession are in many ways synonymous with macroethics. Analysis of the engineering codes of ethics and educational requirements are used to support these arguments, and are compared with the perceptions of engineering students and working engineers. The social responsibilities of engineers include human safety and environmental protection in engineering designs. But it may extend further to include pro bono work and considerations of social justice issues. Research has found that perceptions of the professional social responsibilities of engineers vary across different countries/cultures, engineering disciplines (e.g., mechanical versus environmental engineers) and by gender. The impact of engineering education and broader college experiences on evolving notions of professional social responsibility will be described, in particular community engagement. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. 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Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"19",type:"subseries",title:"Animal Science",keywords:"Animal Science, Animal Biology, Wildlife Species, Domesticated Animals",scope:"The Animal Science topic welcomes research on captive and wildlife species, including domesticated animals. The research resented can consist of primary studies on various animal biology fields such as genetics, nutrition, behavior, welfare, and animal production, to name a few. 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The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:320,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/74340",hash:"",query:{},params:{id:"74340"},fullPath:"/chapters/74340",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()