Death toll in pandemic crises in history (source: Author working sheet).
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8345",leadTitle:null,fullTitle:"Boundary Layer Flows - Theory, Applications and Numerical Methods",title:"Boundary Layer Flows",subtitle:"Theory, Applications and Numerical Methods",reviewType:"peer-reviewed",abstract:'Written by experts in the field, this book, "Boundary Layer Flows - Theory, Applications, and Numerical Methods" provides readers with the opportunity to explore its theoretical and experimental studies and their importance to the nonlinear theory of boundary layer flows, the theory of heat and mass transfer, and the dynamics of fluid. With the theory\'s importance for a wide variety of applications, applied mathematicians, scientists, and engineers - especially those in fluid dynamics - along with engineers of aeronautics, will undoubtedly welcome this authoritative, up-to-date book.',isbn:"978-1-83968-186-8",printIsbn:"978-1-83968-185-1",pdfIsbn:"978-1-83968-187-5",doi:"10.5772/intechopen.78474",price:119,priceEur:129,priceUsd:155,slug:"boundary-layer-flows-theory-applications-and-numerical-methods",numberOfPages:234,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"14d9725e87983a03938f073f6c5ee815",bookSignature:"Vallampati Ramachandra Prasad",publishedDate:"January 22nd 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8345.jpg",numberOfDownloads:9586,numberOfWosCitations:5,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:10,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:22,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 29th 2018",dateEndSecondStepPublish:"November 19th 2018",dateEndThirdStepPublish:"January 18th 2019",dateEndFourthStepPublish:"April 8th 2019",dateEndFifthStepPublish:"June 7th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"146601",title:"Dr.",name:"Vallampati",middleName:null,surname:"Ramachandra Prasad",slug:"vallampati-ramachandra-prasad",fullName:"Vallampati Ramachandra Prasad",profilePictureURL:"https://mts.intechopen.com/storage/users/146601/images/system/146601.png",biography:"Over the past decade, Prof. V. Ramachandra Prasad has worked in the areas of multi-physical fluids dynamics and numerical simulation. His work has investigated complex phenomena of interest in mechanical engineering, applied mathematics, chemical engineering, and material processing. He has made fundamental contributions in magnetic fluid dynamics, thermal radiation heat transfer, fluid modeling, micropolar non-Newtonian hydrodynamics, magnetic induction flows, viscoelastic liquid flows, porous media, and boundary flows. He has published more than 150 journal articles in these areas and has made numerous conference presentations. He has published six books on radiation heat transfer, thermo-diffusion and diffusion-thermo effects boundary layers’ flows, and viscoelastic flows. His more recent work has involved non-Newtonian fluid dynamics, fluid-particle suspensions, and lid-driven cavities. He has used the numerical methods of finite difference, finite element, network simulation, and finite volume codes to solve problems in his areas of research in collaboration with US, Indian, Spanish, British, and Taiwanese researchers. He is a professor of Mathematics at Vellore Institute of Technology, Vellore, India.",institutionString:"Vellore Institute of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Vellore Institute of Technology University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"970",title:"Mathematical Physics",slug:"mathematical-physics"}],chapters:[{id:"65410",title:"3D Boundary Layer Theory",doi:"10.5772/intechopen.83519",slug:"3d-boundary-layer-theory",totalDownloads:950,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Some new analytical results in 3D boundary layer theory are reviewed and discussed. It includes the perturbation theory for 3D flows, analyses of 3D boundary layer equation singularities and corresponding real flow structures, investigations of 3D boundary layer distinctive features for hypersonic flows for flat blunted bodies including the heat transfer and the laminar-turbulent transition and influences of these phenomena on flows, and the new approach to the analysis of the symmetric flow instability over thin bodies and studies of the control possibility with the electrical discharge using new model of this phenomenon interaction with the 3D boundary layer. Some new analytical solutions of boundary layer and Navier-Stokes equations are presented. Applications of these results to analyze viscous flow characteristics of real objects such as aircraft wings, fuselages, and other bodies are considered.",signatures:"Vladimir Shalaev",downloadPdfUrl:"/chapter/pdf-download/65410",previewPdfUrl:"/chapter/pdf-preview/65410",authors:[null],corrections:null},{id:"66522",title:"TBL-Induced Structural Vibration and Noise",doi:"10.5772/intechopen.85142",slug:"tbl-induced-structural-vibration-and-noise",totalDownloads:835,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"One of most import noise sources in a jet powered aircraft is turbulent boundary layer (TBL) induced structural vibration. In this chapter, the general model for the prediction of TBL-induced plate vibration and noise is described in detail. Then numerical examples for a typical plate are illustrated. Comparisons of plate vibration and radiated noise between numerical results and wind tunnel test are presented. The effects of structural parameters on modal-averaged radiation efficiency and therefore the radiated noise are discussed. The result indicates that an increment of flow velocity will increase the acoustic radiation efficiency below the hydrodynamic coincidence frequency range. The main reason for this phenomenon is that a higher convection velocity will coincide with lower order modes which have higher radiation efficiencies.",signatures:"Zhang Xilong, Kou YiWei and Liu Bilong",downloadPdfUrl:"/chapter/pdf-download/66522",previewPdfUrl:"/chapter/pdf-preview/66522",authors:[null],corrections:null},{id:"66869",title:"Roughness Effects on Turbulence Characteristics in an Open Channel Flow",doi:"10.5772/intechopen.85990",slug:"roughness-effects-on-turbulence-characteristics-in-an-open-channel-flow",totalDownloads:1158,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"A comprehensive study was carried out to understand the effects of roughness on the turbulence characteristics of flow in an open channel and would be presented in this chapter. Tests were conducted with four different types of bed surface conditions (an impermeable smooth bed, impermeable rough bed, permeable sand bed and an impermeable bed with distributed roughness) and at two different Reynolds number (Re = 47,500 and 31,000). The variables of interest include the mean velocity, turbulence intensity, Reynolds shear stress, shear stress correlation and higher-order moments. Quadrant decomposition was also used to extract the magnitude of the Reynolds shear stress from the turbulent bursting events. The effect of bed roughness on the turbulence characteristics can be seen throughout the depth of flow and thus dispute the ‘wall similarity hypothesis’. In comparison to other roughness, distributed roughness shows the greatest effect on both streamwise and vertical turbulence intensities. Velocity triple products that reflects the transportation of turbulent kinetic energy is also seen to be affected by roughness of the channel bed with a variation of 200–300% compared to the flow over smooth bed. To analyze the turbulent bursting events, quadrant decomposition tools were used and found that the roughness affected heavily in the production of extreme turbulent events. The increases of the intensity and frequency of this turbulent burst causes the increase of instantaneous Reynolds shear stress. Transport of the sediment, pollutant suspension from the channel bed, changing the composition of the nutrient in the flow, sustainability of the benthic organisms, entrainment and exchange of energy and momentum are all influenced by this change of Reynolds shear stress. The sand used to form the various bed roughness conditions is same but found that the effect on different turbulence characteristics are different for different roughness. This is a strong indication that the geometric formation of the roughness is the cause of the differences in turbulence characteristics for different roughness formed by the same sand grain.",signatures:"Abdullah Faruque",downloadPdfUrl:"/chapter/pdf-download/66869",previewPdfUrl:"/chapter/pdf-preview/66869",authors:[{id:"217678",title:"Associate Prof.",name:"Abdullah",surname:"Faruque",slug:"abdullah-faruque",fullName:"Abdullah Faruque"}],corrections:null},{id:"65415",title:"Leading Edge Receptivity at Subsonic and Moderately Supersonic Mach Numbers",doi:"10.5772/intechopen.83672",slug:"leading-edge-receptivity-at-subsonic-and-moderately-supersonic-mach-numbers",totalDownloads:772,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter is a review of the receptivity and resulting global instability of boundary layers due to free-stream vortical and acoustic disturbances at subsonic and moderately supersonic Mach numbers. The vortical disturbances produce an unsteady boundary layer flow that develops into oblique instability waves with a viscous triple-deck structure in the downstream region. The acoustic disturbances (which have phase speeds that are small compared to the free stream velocity) produce boundary layer fluctuations that evolve into oblique normal modes downstream of the viscous triple-deck region. Asymptotic methods are used to show that both the vortically and acoustically-generated disturbances ultimately develop into modified Rayleigh modes that can exhibit spatial growth or decay depending on the nature of the receptivity process.",signatures:"Marvin E. Goldstein and Pierre Ricco",downloadPdfUrl:"/chapter/pdf-download/65415",previewPdfUrl:"/chapter/pdf-preview/65415",authors:[null],corrections:null},{id:"65411",title:"Transition Modeling for Low to High Speed Boundary Layer Flows with CFD Applications",doi:"10.5772/intechopen.83520",slug:"transition-modeling-for-low-to-high-speed-boundary-layer-flows-with-cfd-applications",totalDownloads:1650,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Transition modeling as applied to CFD methods has followed certain line of evolution starting from simple linear stability methods to almost or fully predictive methods such as LES and DNS. One pragmatic approach among these methods, such as the local correlation-based transition modeling approach, is gaining more popularity due to its straightforward incorporation into RANS solvers. Such models are based on blending the laminar and turbulent regions of the flow field by introducing intermittency equations into the turbulence equations. Menter et al. pioneered this approach by their two-equation γ-Reθ intermittency equation model that was incorporated into the k-ω SST turbulence model that results in a total of four equations. Later, a range of various three-equation models was developed for super-/hypersonic flow applications. However, striking the idea that the Reθ-equation was rather redundant, Menter produced a novel one-equation intermittency transport γ-equation model. In this report, yet another recently introduced transition model called as the Bas-Cakmakcioglu (B-C) algebraic model is elaborated. In this model, an algebraic γ-function, rather than the intermittency transport γ-equation, is incorporated into the one-equation Spalart-Allmaras turbulence model. Using the present B-C model, a number of two-dimensional test cases and three-dimensional test cases were simulated with quite successful results.",signatures:"Unver Kaynak, Onur Bas, Samet Caka Cakmakcioglu and Ismail Hakki Tuncer",downloadPdfUrl:"/chapter/pdf-download/65411",previewPdfUrl:"/chapter/pdf-preview/65411",authors:[null],corrections:null},{id:"67295",title:"Physical Models of Atmospheric Boundary Layer Flows: Some Developments and Recent Applications",doi:"10.5772/intechopen.86483",slug:"physical-models-of-atmospheric-boundary-layer-flows-some-developments-and-recent-applications",totalDownloads:858,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Experimental studies on wind engineering require the use of different types of physical models of boundary layer flows. Small-scale models obtained in a wind tunnel, for example, attempt to reproduce real atmosphere phenomena like wind loads on structures and pollutant dispersion by the mean flow and turbulent mixing. The quality of the scale model depends on the similarity between the laboratory-generated flow and the atmospheric flow. Different types of neutral atmospheric boundary layer (ABL) including full-depth and part-depth simulations are experimentally evaluated. The Prof. Jacek Gorecki wind tunnel of the UNNE, Argentina, and the Prof. Joaquim Blessmann closed-return wind tunnel of the UFRGS, Brazil, were used to obtain the experimental data. Finally, some recent wind engineering applications of this type of physical wind models are shown.",signatures:"Adrián R. Wittwer, Acir M. Loredo-Souza, Mario E. De Bortoli and Jorge O. Marighetti",downloadPdfUrl:"/chapter/pdf-download/67295",previewPdfUrl:"/chapter/pdf-preview/67295",authors:[null],corrections:null},{id:"69291",title:"Dimple Generators of Longitudinal Vortex Structures",doi:"10.5772/intechopen.83518",slug:"dimple-generators-of-longitudinal-vortex-structures",totalDownloads:920,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Visual research of characteristic features and measurement of velocity and pressure fields of a vortex flow inside and nearby of a pair of the oval dimples on hydraulically smooth flat plate are conducted. It is established that depending on the flow regime inside the oval dimples, potential and vortex flows with ejection of vortex structures outside of dimples in the boundary layer are formed. In the conditions of a laminar flow, a vortex motion inside dimples is not observed. With an increase of flow velocity in dimples, boundary layer separation, shear layer, and potential and circulating flows are formed inside the oval dimples. In the conditions of the turbulent flow, the potential motion disappears, and intensive vortex motion is formed. The profiles of longitudinal velocity and the dynamic and wall-pressure fluctuations are studied inside and on the streamlined surface of the pair of oval dimples. The maximum wall-pressure fluctuation levels are pointed out on the aft walls of the dimples. The tonal components corresponding to oscillation frequencies of vortical flow inside the dimples and ejection frequencies of the large-scale vortical structures outside the dimples are observed in velocity and pressure fluctuation spectra.",signatures:"Volodymyr Voskoboinick, Andriy Voskoboinick, Oleksandr Voskoboinyk and Volodymyr Turick",downloadPdfUrl:"/chapter/pdf-download/69291",previewPdfUrl:"/chapter/pdf-preview/69291",authors:[null],corrections:null},{id:"65807",title:"Thermal-Hydrodynamic Characteristics of Turbulent Flow in Corrugated Channels",doi:"10.5772/intechopen.84736",slug:"thermal-hydrodynamic-characteristics-of-turbulent-flow-in-corrugated-channels",totalDownloads:677,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The heat transfer-flow characteristics of turbulent flow inside corrugated channels heated by constant heat flux are numerically investigated. The rate of heat transfer, pressure drop, and performance evaluation criterion is determined for smooth channel and various designs of corrugated channels at the Reynolds number ranged from 5000 to 60,000. The effect of rib arrangement distributions of inward, outward, and inward-outward ribs are examined. The various rib configurations of corrugated channels are also tested. In addition, the influences of rib roughness parameters (height, pitch, and width) and rib shapes (semicircular, trapezoidal, and rectangular) are researched. The Reynolds-averaged Navier-Stokes equations (RANS) are used to model the governing flow equations. The computational model is validated through a reasonable agreement between the present numerical results and the outcomes of related works. For different geometrical and operating conditions, the results revealed that the rate of heat exchange in corrugated channels exceeds higher than that of smooth ones but with additional pressure loss. Moreover, the rib arrangements, rib configuration, and rib roughness parameters exhibit a relatively significant effect on the performance of the corrugated channels. On the other hand, the influence of the rib shapes seems to be small.",signatures:"Nabeel S. Dhaidana and Abdalrazzaq K. Abbas",downloadPdfUrl:"/chapter/pdf-download/65807",previewPdfUrl:"/chapter/pdf-preview/65807",authors:[null],corrections:null},{id:"68809",title:"Singularly Perturbed Parabolic Problems",doi:"10.5772/intechopen.84339",slug:"singularly-perturbed-parabolic-problems",totalDownloads:778,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The aim of this work is to construct regularized asymptotic of the solution of a singularly perturbed parabolic problems. Namely, in the first paragraph, we consider the case when the scalar equation contains a free term consisting of a finite sum of the rapidly oscillating functions. In the first paragraph, it is shown that the asymptotic solution of the problem contains parabolic, power, rapidly oscillating, and angular boundary layer functions. Angular boundary layer functions have two components: the first one is described by the product of a parabolic boundary layer function and a boundary layer function, which has a rapidly oscillating change. The second section is devoted to a two-dimensional equation of parabolic type. Asymptotic of the scalar equation contains a rapidly oscillating power, parabolic boundary layer functions, and their product; then, the multidimensional equation additionally contains a multidimensional composite layer function.",signatures:"Asan Omuraliev and Ella Abylaeva",downloadPdfUrl:"/chapter/pdf-download/68809",previewPdfUrl:"/chapter/pdf-preview/68809",authors:[null],corrections:null},{id:"70366",title:"Solving Partial Differential Equation Using FPGA Technology",doi:"10.5772/intechopen.84588",slug:"solving-partial-differential-equation-using-fpga-technology",totalDownloads:992,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter introduces the method of using CNN technology on FPGA chips to solve differential equation with large space, with lager computing space, while limitation of resource chip on FPGA is needed, we have to find solution to separate differential space into several subspaces. Our solution will do: firstly, division of the computing space into smaller areas and combination of sequential and parallel computing; secondly, division and combination of boundary areas that are required to be continuous to avoid losing temporary data while processing (using buffer memory to store); and thirdly, real-time data exchange. The control unit controls the activities of the whole system set by the algorithm. We have configured the CNN chip for solving Navier-Stokes equation for the hydraulic fluid flow successfully on the Virtex 6 chip XCVL240T-1FFG1156 by Xilinx and giving acceptance results as well.",signatures:"Vu Duc Thai and Bui Van Tung",downloadPdfUrl:"/chapter/pdf-download/70366",previewPdfUrl:"/chapter/pdf-preview/70366",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10284",title:"Porous Fluids",subtitle:"Advances in Fluid Flow and Transport Phenomena in Porous Media",isOpenForSubmission:!1,hash:"df79c29efe12a76f9250f23370bb8e37",slug:"porous-fluids-advances-in-fluid-flow-and-transport-phenomena-in-porous-media",bookSignature:"Vallampati Ramachandra Prasad",coverURL:"https://cdn.intechopen.com/books/images_new/10284.jpg",editedByType:"Edited by",editors:[{id:"146601",title:"Dr.",name:"Vallampati",surname:"Ramachandra 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In the light of pharmaceutical biotechnology, three different approaches could be catered to resolve this issue. First, Computer-Aided Drug Design (CADD) approach. Second, rational drug design in the wet lab approach. Third, is the advanced drug delivery system. These approaches are influenced heavily by advances in life sciences such as the inception of structural bioinformatics as an independent study, the establishment of nanobiotechnology as a standard approach in drug design, and high advancement in structural biology such as the development of the CryoEM method. This book will focus on providing possible solutions toward this ongoing COVID-19 pandemic, in the light of those advancements in life sciences.
",isbn:"978-1-80356-990-1",printIsbn:"978-1-80356-989-5",pdfIsbn:"978-1-80356-991-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"f8092a491f68ca0b63cc6d40936a010a",bookSignature:"Dr. Arli Aditya Parikesit",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg",keywords:"Molecular Docking, Molecular Dynamics, Biomolecular Modeling, Homology Modeling, In Vitro Drug Testing, In Vivo Drug Testing, Structural Biology, Nano Delivery, Prodrug, Smart Drug, Liposome, Wet Lab",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 12th 2022",dateEndSecondStepPublish:"June 22nd 2022",dateEndThirdStepPublish:"August 21st 2022",dateEndFourthStepPublish:"November 9th 2022",dateEndFifthStepPublish:"January 8th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"14 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A researcher in transcriptomics, immunoinformatics, and structural bioinformatics, ISBB and APBIONET member, currently involved in COVID-19 Drug and Vaccine design. 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In order to pursue a degree in Bioinformatics, he accepted an offer from DAAD (German Academic Exchange Service) to conduct doctorate research at the Bioinformatics Group, Faculty of Informatics and Mathematics, University of Leipzig, Germany. His doctoral research is focused on the utilization of modern protein domain annotation techniques to the three domains of life. In addition, Dr. Arli is also an expert on immunoinformatics, bioinformatics algorithm, structural bioinformatics, in silico drug design, and in silico transcriptomics. 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In all these years, there are some incidences experienced by a human, which reshaped the entire behavior of human. World war I, II, cold war era and more recently the incident of 9/II all these incidences in world history suddenly changed the power centers, the world moved from unipolar to bipolar or even toward multipolar world order. Furthermore, all these event or incidence dramatically changed the over economic systems, way of governing nations and even changed our literature as well. Even all these incidences changed the lifestyle of the entire world, similarly, the ongoing pandemic crises of covid-19 will have a permanent and everlasting impact on our lives [1, 2].
It is generally believe that once pandemic crises will over; the world will be not the same as it was before. Technically, due to hyper-growth, presence of high tech inventions, innovation and more especially the extensive use to the internet already made this world liquidness thus we are unable to identify where it will be stopped or freeze. On the other hand, nowadays, this pandemic situation just created the new standard among us; it is also true; thus, it locked down the entire world in one corner. At the moment, due to this pandemic, the circle of growth has become stiff. Thousands of airlines are not functioning, and the majority of the tourist places are closed, furthermore there not any educational activities are going on in most effected countries of covid-19. Similarly; on the other hand, this world not facing the pandemic situation the first time. History reveals that there were numerous pandemic crises experienced by this world. Due to all these pandemic crises, millions of people lost their lives. Table 1, indicates major pandemic crises experienced by the world in history.
Year | Pandemic crises | No. of deaths |
---|---|---|
165 AD | Antonine Plague | 5,000,000 |
541 AD | Justinianic Plague | 100,000,000 |
1334 | Black Death Plague | 25,000,000 |
1576 | Cocoliztli Epidemics | 15,000,000 |
1817 | The first Cholera Pandemic | 150,000 |
1855 | The third Plague | 15,000,000 |
1889 | Russin Flu | 360,000 |
1919 | Spanish flu | 50,000,000 |
1957 | Asian Flu | 1,100,000 |
2004 | SARS | 813 |
2014 | EBOLA | 11,315 |
2020 | Covid-19 (until 08-01-2020) | 712,126 |
Death toll in pandemic crises in history (source: Author working sheet).
In the recent era, especially at the beginning of the 21st century, two more pre-mature pandemic crises hit numerous countries of the world. Avian influenza, which is known as bird flow virus, infected hundreds of people from 2003 to 2011 in almost 60 countries of the world. According to the World Health Organization estimation, more than 1500 people died due to this influenza. Furthermore, in 2009 swine flu (H1N1) spread over more than 100 countries of the world, and approximately 550,000 people lost their lives due to this (Centers for Disease Control and Preventions). On the other hand, from 2013 to 2016, the Ebola virus hit western African countries, and more than 11,000 people died. Similarly, there are numerous diseases which cause millions of death worldwide every year. Due to HIV (AIDS) 32 million people died, whereas due to malaria, just in 2018, approximately 400,000 people died (World Health Organization).
Before discussing actual environmental issues, it essential to describe the phenomenon of climate change. United Nations Framework Convention on Climate Change defines it as “a change of climate which is attributed directly or indirectly to human activity that alters the composition of the global atmosphere and which is in addition to natural climate variability observed over comparable periods” [3]. Similarly, on the other hand, Rahman, [4] define it as ‘our climate is changing, largely due to the observed increases in human-produced greenhouse gases. Greenhouse gases absorb heat from the sun in the atmosphere and reduce the amount of heat escaping into space. This extra heat is the primary cause of observed changes in the climate system over the 20th century. However one question arises here, why environment or typical climate change matter for us; as it represent our common future and that particular phrase of common future is defined by United Nation’s Brundtland Report 1987 as ‘sustainable development’. Leggett and Carter [5] refer definition of sustainable development, which is described by united nation conference on Sustainable development; Sustainable development meets the needs of the present without compromising the ability of future generations to meet their own needs. Seem like the guiding principle for long-term global development; sustainable development consists of three pillars: economic development, social development, and environmental protection.
The adverse effect of climate change is exceptionally massive; somehow, it matters of survival of humankind on earth. Sustainability can be achieved in a balanced way only if we care about the world. Among three pillars of sustainable development, which are environment, economic and social; environment considers as one of the most significant pillar of sustainable development. According to the UN estimations, for human survival till now 1.6 planet resources we already used and while observing the acceleration by which we (humans) utilize natural resources two piles of the earth will be required by 2030 (Global Footprint Network). As Foley et al. [6] mentions, in his ecological overshoot, he is concerned about the conversion of resources into waste faster and vice versa. The most noticeable effects of overshooting or overutilization of natural resources can be observed through diminishing forest covers, collapsing fisheries, rapid fall in water level under the earth crust, carbon dioxide emissions which all are creating global climate change. Global warming affects all species which are living on the earth. According to living planet report 2014, the population of living species has declined by 52% from 1970 (World Wildlife Fund). The idea of Sustainable Development Goals become more critical among intellectual, economist, and scientist due to the growing urgency of sustainable development for the entire world, as climate change and medical issues are those common challenges.
Table 2 illustrates some of the adverse features of climate change are massively noticed in recent decades. Due to industrialization and foreign direct investment outflow from developed countries to developing countries where environmental laws are not so much strict bad affect atmosphere. As massive harmful gases in the shape of Carbon dioxide, Sulfur dioxide and nitrogen dioxide are added in the atmosphere, which eventually decreases oxygen and harms our environment which surrounds us. Similarly, one of the most destructive effects of all these harmful gases in our environment and atmosphere is depletion of the ozone layer which protect humans and surface of the earth from the adverse impact of sun rays. The concentration of harmful gases in the atmosphere increases the average temperature of the world, which negatively affect the glaciers and phenomenon of melting ice increases very rapidly. Melting of ice in summer season induces floods in our river, which causes loss of human life and another material loses as well. However, massive waves in the sea and similarly melting ice slabs directly increase sea level, which influences the life of people living on the seashores. The Figure 1 indicates the average increase in world temperature recorded in the last 40 year. Thus we can see that average temperature indicating an upward trend, which is an indeed alarming situation for everyone.
Climate changer features | Why it matters? |
---|---|
Green House Gases Concentration | Emission of Green House Gases thorough industrialization, traveling etc. is increasing the GHG concentration in the atmosphere. |
Ozone Layer depletion | A slow, steady decline of about 4% per decade in the total volume of ozone in Earth’s stratosphere (the ozone layer) since the late 1970s |
Melting of Ice | Greenland lost 150 km3 to 250 km3 (36 mi3 to 60 mi3) of ice per year between 2002 and 2006 and Antarctica lost about 152 km3 (36 mi3) of ice between 2002 and 2005 |
Rise in Sea level | Global sea level rose about 17 cm (6,7 in) in the last century |
Temperature rise in sea water | With the top 700 m (about 2300 ft) of ocean showing warming of 0,16C since 1969 due to absorbed increased heat of the Earth |
Unwelcome rains and storms | World is experience every year unwell come rains and floods and thousands of people lost their life’s. |
Adverse affect of climate change (source: Author working sheet).
Average temperature trend observed by NASA since 1980. Source: Rahmstorf et al. [
The world-renowned, global climate change activist, Greta Thunberg Said, “And Yes I know that we need a system change rather than individual change, but you cannot have one without the other. If we explore the history, all the big changes in society have been started by the people at the grassroots level. No system change can come without pressure from the large group of individual’. Thus, it is right the entire world needs collective efforts to face all the challenges to arise by climate change. Moreover, the highest responsibility is on the shoulder of the business community, policy markers, world leaders and politicians. The business community employs by using the labor from the factor of production; moreover, they also put capital along with the utilization of land resources which are also the factor of production. However, unsustainable utilization of land resources creates massive climate change threats. Every year tons of plastic waste is buried without recycling under the surface of the earth and dump in oceans as well.
Similarly, in order to fight against hunger and our food necessities, our farmer’s working day and night on land resources and grow crops and planted fruits trees. However, by using heavy pesticides and fertilizer we can double the quantity of wheat in less time but on the other hand, one of the significant adverse effects of pesticides are the death of eco-friendly insects. Similarly, extensive use of fertilizer is finishing the natural tendency of soil to grow crops.
Every next coming day increases the world population in such manner that, every consecutive day noted as the highest population ever recorded in the world. Similarly, our rural areas are finishing very rapidly. On the other hand, urban concentration is increasing, which cause a heavy abnormal burden on cities. One of the most major adverse effects can be observed in developing countries and more specifically in unplanned cities as the majority of unplanned cities in the world are expanding in such manner that majority of the people living there without basic human needs such as access of freshwater, sewerage system and some of the places even with the access of electricity. The UN Framework Convention on Climate Change [8] in their report predicted that billions of people in developing countries would face shortages of water, food and more significant risks to health. Thus it requires immediate action in a sustainable way along with effective planning and then assessments. The issue which arises due to climate change will not be solved suddenly; in fact, it is a long term process which requires proper planning and contribution of every stakeholder and individual. As we already discussed earlier, it is not an issue of one individual, single community or a country’s problem. Thus its global matter, therefore; requires worldwide attention and contribution.
Similarly, as Figure 2 indicates the sunlight rays pass through the ozone layer, which eventually increases the temperature. Achieving sustainability requires collective action by the entire stakeholder of society; in fact, it requires action from the farmer working in the farm and earning for his family as well as a high corporate executive. One of the significant issues now a day’s faced by our society is income inequalities or unequal distribution of wealth, which divide our societies into different classes. One of the most destructive factors which arise in our society is that the rich become richer and the poor become poorer. Similarly, income inequalities can be observed in developed countries and as well as in developing countries. In developing countries usually, rich people have access toward the higher political level.
Ozone layer and our world. Source: Global Climate Change, [
One of the most challenging situations can be observed in developing countries in which wealthy class, provide access to the foreigner investor in their country and due to weak local legal system and absence of environmental laws and regulations, heavily polluting industries is formed in host countries which adversely affect the atmosphere. However, recently it had also been noticed that polluted industries also induce health issue for the local communities, including lungs cancer and asthma. The more adverse effect can be observed in developing countries in the shape of massive life losses where medical facilities are not so much advance and widely available. Apparently, in such situation, it is the responsibility of all the stakeholders to identity such industries which create an environmental hazard as well as, higher leadership should also take strict action to fight against global warming issues [10]. On the other hand, it has also been observed that in developing countries the industrial waste is directly dumped into the rivers and sea without any further recycling [11]. Therefore life undersea and river profoundly affected as well. Similarly, the extensive use of plastics also harms our surroundings.
Air pollution is one of the most considerable catalyst factors which is harming our environment. Air Pollution defined as release of poisonous gases, which are emitted by factories and transportation. As due to the pandemic crises, from beginning of the year most of the countries of the world were in lockdown situation. Due to the fact, lock down situation ultimately affects every sector of the world. The overall world output dramatically decreased due to the lockdown and millions of the people lost their jobs. Figure 3, indicate impact of Covid-19 on different economic activities around the world.
Quarterly word GDP.
Similarly an empirical study conducted by Barro et al. [12] reveal due pandemic crises on average 2.1% death rate could cause decline of averagely 6% of world GDP and 8% decline in private consumption. Furthermore, in terms of macroeconomic impact, Coibion et al. [13] empirically analysis pandemic impact using survey on household in the US. They conclude that, due to pandemic crises consumption and employment decreased where as inflation and economic uncertainty increased.
It is true to argue that, due to the massive lockdown in the world overall production and consumption decreased. Lockdown indicate downward trend of industrial output and due to ‘stay safe stay health’ less transportation vehicles were used by people which directly impact on the overall air pollution of the world [14].
In terms of empirical studies, Brodeur et al. [15] mention in their work ‘safer-at-home’ policies indicatively decreased air pollution across US counties. Therefore we can argue that one the key factor which contribute downward trend of air pollution is transportation vehicles thus consumption of gasoline as fuel. Similarly, Cicala et al. [16] identified in USA the average sales of gasoline from 2007 to 2019 average recorded as 8000 to 9000 barrels per day, however due to the lockdown and less mobility, the average sales drop at 5000 barrels per day until 12th week of 2020 (Figure 4).
Sales of gasoline in USA from 2007 to 2020 (until 12th week). Source: Cicala et al. [
On the hand, it is also true beside industrial sector and road transportation the large consumption sector of fuel is airline industry, although due the lockdown situation massive airlines of the world grounded there air craft’s and international mobility stopped as well. Indeed, that particular factor also decreases overall air pollution.
It has be also observed that, air travel thus airline industry account for about 2.5% of global CO2 emission; furthermore it is predicted that until 2050 airline industry could take up a quarter of the world’s carbon budget and it will cause for 1.5 degree Celsius world temperature [17]. Figure 5; indicate first quarter international flights and transportation activity around the world.
International flight and transportation activity around the world. Source: International Energy Agency [
In terms of china, Almond et al. [19] investigate nexus between air pollution and gases emission during covid-19 crises. They conclude that during the crises NO2 emission decline whereas SO2 did not fall. Furthermore they also mention that, in overall China (PM2.5) emission decreased by 22%. The major cause of reduction in air pollution is due to less personal vehicle usage which is heavily responsible for NO2 emission. Similarly, in case of china another study conducted by He et al. [20] also concluded same results, due to the lockdown in china PM2.5 concentration decline by 25%. That particular phenomenon were recorded in more industrialized cities, therefore it is true to argue that the fall in industrial production is positively associated with reduction in air pollution. One more study conducted by Yao et al. [21], mention that higher humidity causing spread of the Covid-19, and they further illustrate that high level of NO2 emission, playing role as catalyst agent and causing more Covid-19 spread with in the china.
After the lockdown, the clean environment has been observed all around the world, not only in high industrialized countries, more specifically in European countries due to the lockdown situation, and the concentration of NO2 emission in the air rapidly decreased. Figure 6, illustrate the decline of NO2 emission in most of the European countries.
Percentage change of NO2 emission in European countries. Source: Myllyvirta and Thieriot [
Similarly not only European countries have to experience clean air, on the other hand, a country like India, which is the second-highest populated country of the world, due to the lockdown situation the trend of air pollution also declined in India [23]. It is also true that, due to lockdown in massive countries of the world, the overall pollution decreases rapidly; thus, environment restores as it was 50 year ago. Not only, lockdown reduce air pollution; eventually, it also impacts on water pollution. In Europe, the death toll of covid-19 record massively high in Italy, therefore during the lockdown in Italy tourist arrival become zero almost, which impact on water quality in the canals of Venice. After couples of decades, the resident of Venice city has noticed clean water and marine life in the channels again [2]. The significant declines which has also been observed in the pattern of the overall consumption of electricity. As many of the people working from home, this directly decreases electricity consumption. Furthermore, the countries which heavily depend on electricity production via coal have experienced a decline in CO2 emission as well. It is right to argue that covid-19 ultimately reduced the consumption of electricity and fuel consumption for producing electricity as well [24]. Below Figure 7 indicate, the overall pattern of NO2 emission in Europe during 2019 and 2020, thus after the lockdown situation.
NO2 emission in Europe comparative analysis between March April 2019–2020. Source: European Space Agency, [
The positive change and transformation in environment is generally due to the lockdown situation in terms of clean air and clean water channels, will not be long-lasting and it is expected that our environment once again will harm as the world will experience normal cycle of life; thus we will again experience massive air and other pollution [26]. Massive corporate allow remote work for their employees. Remote work will enable people less mobility, thus, which decrease the usability of the vehicle. However at the moment it is not responsibility of single person or a country to maintain that transformation, thus we should promote a green ideology, which will ultimately reduce air pollution and on the other hand green concept will improve countries’ social, economic and environmental performance. Furthermore, we should also focus on renewable energy in overall logistics operations, as it ultimately improves environmental performance by reducing emission whereas environmental performance is negatively correlated with public health expenditure as explained in literature [27].
The aim of this chapter is to discuss the association between Covid-19’s outbreak and its environmental effects on society. The debate indicates that the global lockout eliminates environmental emissions. As a result of the global shutdown, we have induced economic downturn across the world, but on the other hand, in a better climate, we are gaining a transformed world. There is no doubt that once the world engine start-up after Covid-19, pollution and waste will started to piling-up in our surrounding, which will not damaging to the health but also environmental sustainability. The implementation of different step-by-step strategies demonstrates that the environment will gradually shift from polluted world to a green one. In order to maintain environmental sustainability, policymakers and governmental bodies should develop a road-map to protect environmental sustainability.
Following are some suggestions, which may help in the initial phase of planning.
Corporate sector should adopt green and eco-friendly practices in their businesses to improve environmental sustainability.
Governmental bodies should formulate strict eco-friendly policies and provide awareness to the corporate leaders through different workshops.
Regulatory bodies may encourage renewable energy and green projects through providing subsides and tax-exemptions to the enterprises.
Governmental bodies embossed heavy penalties on the polluted firms, which will not only create pressure on firms to adopt sustainable practices but also motivate to the eco-friendly firms.
Regulatory authorities may increase the fossil fuel and non-green energy prices, which will ultimately create pressure on firms to adopt renewable energy in their operations.
Furthermore, In order to achieve industrial productivity for green growth, the reliance upon energy use of fossil fuels should be replaced with renewable energy sources. As for the sustainable development of the country, the efficient use of natural resources, including oil rentals, ores and metal exports is imperative. On the other hand, Green finance will offer an incentive to fund sustainable items that lead to the digital mobilization of renewable energy and industrial growth initiatives. Furthermore, economic policies will help to achieve a smooth growth agenda through capital market promotion, technological advances, and the provision of environmental subsidies, to reduce the environmental adverse externalities of the production and consumption sectors. In the last, Public-private cooperation on the resource market is necessary in order to support sustainable economic development, which makes it incredibly necessary to provide insurance and business services such that green development is encouraged.
This work supported by the China Postdoctoral Science Foundation (No. 2019 M660700), and the Beijing Key Laboratory of Megaregions Sustainable Development Modeling, Capital University of Economics and Business (No. MCR2019QN09).
Chronic kidney disease (CKD), a progressive disease, with high morbidity and mortality, therefore associated with increased health costs, is becoming a public health problem because of the increasing incidence and prevalence. For the diagnosis of CKD, biochemical markers are used—glomerular filtration rate, estimated from the level of serum creatinine and urinary albumin/creatinine ratio. For the assessment of the progression of CKD histology can often be helpful, and different new biomarkers are emerging as important tools as well [1].
The use of imagistic methods in the early diagnosis, or to assess the progression of CKD is very limited. Conventional ultrasound is helpful in diagnosing cystic kidney diseases, which represent a small proportion of the causes of CKD. Regarding the most frequent etiologies of CKD (diabetes mellitus, arterial hypertension, glomerular diseases, or chronic tubulointerstitial diseases) information provided by ultrasound is of limited help. Using conventional ultrasound we can quantify the renal size and parenchymal thickness, both decreasing in advanced stages of CKD, when due to the progression of fibrosis, the echogenicity of the renal cortex is increasing [2].
The increased echogenicity, observed by the investigator is however not quantifiable using conventional ultrasound, being therefore subjective. An ultrasound-based method that has proven its utility in the assessment of fibrosis in different other organs (liver in both, diffuse [3, 4] or focal lesions [5], spleen [6, 7], thyroid [8, 9] or prostate [10]), by measuring the stiffness of the tissue is elastography.
Elastography is a method used to quantify the elasticity of tissues. Elasticity is an intrinsic property of tissue, that permits after initial stress, the deformation with a subsequent return to the normal shape [11].
Different methods, corresponding to different technologies can be used to measure tissue elasticity:
Strain elastography (SE) is a qualitative method, the strain images being obtained from the tissue displacement, due to pressure applied by the transducer. SE is mentioned in experimental studies performed in renal transplant recipients when the assessed kidney is superficial [12].
Shear wave elastography
This is a quantitative method, that in contrast to SE does not use the transducer pressure, but high-intensity pulses that generate shear waves in the different tissues. The tissue shear wave speed (SWS) is expressed in m/s and is correlating with tissue stiffness expressed by Young’s modulus (kPa). Performing this method in a stiffer tissue leads to a higher SWS.
Transient elastography (TE) or Fibroscan is known from liver stiffness assessment. Shear waves in TE are generated by controlled external vibration, however, the fact that the obtained image is not superimposed on an ultrasound image, makes it difficult to use in renal assessment. The conclusions of the few published studies using TE in kidneys, underline the fact that the results can be affected by the heterogeneous kidney morphology [13, 14, 15].
Acoustic radiation force impulse (ARFI), in contrast to TE, uses the same transducer to generate shear waves and to image their propagation. The system is integrated into an ultrasound machine, and the ultrasound image is used to guide the site of elastography measurements. As a principle, in ARFI, shear waves are generated inside the organ due to focused acoustic radiation force pushing pulses. After generation the shear waves propagate through the soft tissue, their speed represents the SWS and are progressively attenuated due to their absorption in the soft tissue [16]. There are two different types of ARFI, corresponding to the different methods of obtaining and reporting information:
Point shear wave elastography (pSWE): The result is an average value inside a region of interest (ROI) and the systems/machines that use pSWE are: Virtual touch quantification (VTQ) (Siemens S2000, S3000) (Figure 1), elastography point quantification (ElastPQ) (Phillips Affiniti) (Figure 2).
Shear wave speed imaging (2D-SWE). Instead of an average value, the ROI appears as a color-coded map mosaic inside which the measurement is performed. The systems that use this method are: 2D SWE.SSI technique (Aixplorer) (Figure 3) and 2D SWE.GE (General Electric) (Figure 4).
Kidney SWS (expressed in m/s) measured with a pSWE method: Virtual TouchTM tissue quantification (VTQ), software version 2.0, on a Siemens Acuson S2000TM ultrasound system (Siemens AG, Erlangen, Germany) with a 4CI transducer.
Kidney SWS (expressed in m/s) measured with a pSWE method: Elatography point quantification system (ElastPQ) on a Phillips Affiniti ultrasound system with a 4CI transducer.
Kidney stiffness (expressed in kPa) measured with a 2D-SWE method: 2D-SWE.SSI technique on a SuperSonic imagine Aixplorer® ShearWave™ Elastography machine with a SuperCurved™ SC6-1 transducer.
Kidney SWS measured with a 2D SWE.GE technique using a Logiq E9- General Electric ultrasound system.
Only the two ARFI-based shear wave elastography methods (pSWE and 2D-SWE) seem to be suitable for the assessment of renal diseases.
Both mentioned renal elastography methods (pSWE and 2D-SWE) are ultrasound-based. The image obtained is a normal ultrasound image, and superimposed on it there is the region of interest (ROI), inside which the kidney shear wave speed is measured (Figures 1–4). The result is displayed on the screen and is expressed either in m/s or in kPa.
The preparation of the patient should be the one used for a conventional ultrasound examination, but because the results obtained with elastography are quantifiable, the position of the examined subject should be standardized. Renal elastography should be thus performed with the patient in lateral decubitus, asked to stop breathing for a moment, to minimize breathing motion (Figure 5). Because the elastography method is ultrasound-based, the obtained B-mode US image should have a good quality, to obtain a reliable elastography measurement. Thus, before starting elastography acquisition, the correct scan of the kidneys should be obtained, using the best acoustic window.
For elastography, the patient should be examined in lateral decubitus, to obtain the best acoustic window.
The need for a good standardization of this method comes from the complex architecture of the kidney, which is composed of cortex, medulla, central fat, vasculature, collecting system, and a capsule [17]. This complex structure leads to a high degree of anisotropy, especially at the level of the medulla, composed of tubules that are aligned perpendicular to the renal capsule [17]. Anisotropy is present at the level of the renal cortex as well and is due to the spherical glomeruli and proximal and distal tubules which have a convoluted shape [18].
The consequence of anisotropy of the renal structure is represented by the influence on the kidney stiffness measured using elastography [19]. The results are influenced by the relationship between the direction of the ultrasound main axis and the renal pyramid axis. Thus, if the ROI is put in the mid-portion of the renal parenchyma the two axes are parallel, while if the ROI is at the level of the renal poles the two axes are perpendicular and the obtained SWS is different [20]. To have a standardized approach and because the placement of the ROI in the poles is sometimes difficult, the most common way to place the ROI is in the mid-portion of the renal parenchyma.
Anisotropy of the renal tissue can however be beneficial and used as a diagnostic tool. Standardizing the variation of SWS in the kidney can be used to obtain an anisotropic ratio, that could represent a diagnostic and monitoring marker in CKD [21].
When performing renal elastography, another important issue is the one regarding the positioning of the ROI, because theoretically the measurements should be performed in the renal cortex. It is known that the stiffness of the cortex is higher compared to the stiffness of the medulla [22]. In practice, however, because of the fixed dimension of the ROI, of 1 cm, it is difficult to differentiate between cortex and medulla, and therefore, the measurements will be performed in the renal parenchyma, which contains both cortex and medulla. This difficulty resulting from the dimension of the ROI is further increased in patients with advanced CKD, that have thin parenchyma (sometimes below 1 cm), and elastography results could be biased.
The limited size of the renal parenchyma (compared to the size of the ROI), even in normal kidneys, leads to the necessity of positioning the ROI just beneath the renal capsule. The vicinity of the renal capsule can lead to the appearance of some common ultrasound artifacts that occurs when a sound pulse reverberates back and forth between two strong parallel reflectors, and that leads to increased measured values. These reverberation artifacts are the reason for the recommendation in liver elastography, for example, to put the ROI 1.5–2 cm beneath the capsule to avoid these artifacts, a recommendation that is impossible to use in renal elastography [23].
Despite the above-mentioned difficulties in performing renal elastography, if the approach of the kidneys is standardized, it has been proven that the method has good inter-observer reproducibility, and thus has the potential to be used in clinical practice [24, 25].
In practice and considering the results of the majority of published studies the kidney shear wave speed value should be reported as the median value of five valid measurements, although it has been proven that even three valid measurements are enough [26].
It is difficult to establish the normal values of kidney shear wave speed because even if the measurement is performed at the same cortical level, the reported results are different depending on the different elastography systems used. For pSWE, the normal values range between 2.15 and 2.54 m/s (for the VTQ system) and between 1.23 and 1.54 m/s (for the ElastPQ system) [27]. For 2DSWE-GE, normal values range between 1.71 and 1.79 m/s [28].
An important limitation of elastography is the fact that the different methods that are available, and that have been mentioned previously, are coming from different providers and no correlation tables are available to compare results obtained with different transducers from different manufacturers.
Kidney shear wave speed seems to be influenced by age, with a decrease of renal stiffness in older subjects, and also by gender, with men showing lower values compared to women [29, 30].
The results obtained when performing renal elastography are influenced also by the depth of the kidneys. Kidney shear wave speed is decreasing with increasing organ depth [29, 31, 32]. The assessment becomes difficult in very deep kidneys because the maximum depth of the ROI is 8 cm.
But very superficial kidneys can be difficult to assess as well, because the results are potentially biased due to the different compression of the transducer, being thus operator dependent. It has been proven in a study published by Correas et al., that cortex stiffness is increasing with the increased transducer compression [22]. This problem could influence especially measurements performed in superficial kidneys when the different non-quantifiable transducer force applied, could intervene, leading to different SWSs.
The most promising use of elastography in the hands of a nephrologist should be for the assessment of CKD, to diagnose and quantify the progression, as it has been mentioned in the introduction of this chapter.
There are several studies that are showing that kidney SWS values are significantly increased in patients with CKD compared to normal controls, pointing out that kidneys are stiffer because of chronic disease [33, 34, 35, 36, 37]. These observations are, however, not confirmed in every published study. Other authors have shown that renal stiffness is significantly lower in patients with CKD [24, 38, 39]. A statistically significant relationship between kidney shear wave speed values and renal function, expressed by estimated glomerular filtration rate (eGFR), has been shown as well, with lower kidney SWS associated with lower eGFR [40, 41, 42].
Despite the decrease of kidney SWS with the decrease of eGFR, mentioned in some studies, it was not possible to use elastography to differentiate between the different stages of CKD, because no significant differences could be found between the SWS levels in the different CKD stages [28, 43].
In a meta-analysis comprising seven studies including 639 patients with CKD and 640 normal controls, it has been shown that kidney SWS is decreased in patients with CKD, and there is a decrease of kidney SWS with the progression of CKD (decrease of eGFR). However, the included studies showed an increased heterogeneity [44].
To implement the use of renal elastography in the current practice, for the diagnosis of CKD for example, the finding of cut-off values would be important. However, the attempts published so far are presenting cut-off values for the diagnosis of more advanced stages of CKD, and not for incipient CKD.
Thus, diabetic kidney disease with an eGFR of below 60 ml/min could be predicted using the VTQ system (pSWE) with a sensitivity of 67.4% and a specificity of 67.8%, if kidney SWS was less than 2.32 m/s [45]. Better sensitivity (89.2%) and specificity (76.9%) have been obtained with 2D SWE GE, which predicted CKD if SWS was 1.47 m/s or below [28].
When combining elastography with clinical parameters, such as albuminuria or diabetes duration, and using a logistic regression model, the accuracy of diagnosing even early stages of diabetic kidney disease could be significantly improved, in contrast to the independent use of the different methods [36].
From the studies using liver elastography, we know that fibrosis, which occurs due to the progression of liver disease, leads to an increase in liver stiffness. Because the histological background of chronic kidney disease is renal fibrosis, and especially tubulointerstitial fibrosis, it can be hypothesized that similar changes occur in the kidneys, and therefore, the progression of kidney disease should lead to an increase of SWS. However, as mentioned in the previous chapter, the studies published so far, that compare elastography performed in patients with CKD and normal controls, have shown that not always CKD is associated with an increase in renal stiffness.
Therefore, it would be useful to take a look at those studies that compare histological changes with results obtained using elastography, and to see if there is a relationship between fibrosis and kidney SWS, and to find an explanation to the observation mentioned in some studies that kidney SWS is decreasing in advanced stages of CKD.
The first studies that compare elastography with histological parameters have been performed in renal transplant recipients. Those studies using transient elastography (TE) show a positive correlation between renal stiffness and fibrosis [13, 14, 15, 47], but as already mentioned the use of Fibroscan in the assessment of the kidneys is especially biased by the renal structure. In the studies using pSWE or 2D SWE in transplanted patients, there was a lack of correlation between fibrosis and renal stiffness [48, 49, 50, 51].
In native kidneys, there are studies using different elastography systems (VTQ, ElastPQ) that show, as expected, that severe histological changes, both glomerular and tubulointerstitial, are associated with a statistically significant increase in kidney SWS [33, 52]. Moreover, in a study performed using the 2D-SWE – SSI elastography method, it has been shown that the degree of glomerulosclerosis and tubulointerstitial fibrosis is associated with higher levels of kidney stiffness and that patients with lower kidney SWS showed a better response to corticotherapy [53]. This observation could be explained by the fact that corticotherapy is not effective on fibrosis, but on active glomerular lesions, which probably do not influence renal stiffness.
However not all published studies sustain the mentioned conclusions regarding the relationship between kidney elastography and histological changes, and thus in some studies, no correlations at all have been found between histology and elastography. This is the case of a small study performed in 45 patients with CKD in which no statistically significant correlation of kidney SWS with the studied histological parameters (glomerulosclerosis index, tubular atrophy, interstitial fibrosis) has been found [54]. In another study that has been performed in kidneys used for transplant from living donors, elastography and renal biopsies have been performed before nephrectomy. Although the kidneys with more pronounced interstitial fibrosis had a lower SWS, none of the correlations between histology and elastography was statistically significant [31].
Even more surprising are those studies that show an association of a decreased renal stiffness with fibrosis, for example, that severe histological impairment in CKD is associated with significantly reduced kidney SWS [41], or even that the presence of tubulointerstitial fibrosis or arteriolar hyalinosis leads to significantly decreased values of SWS [55].
Combining elastography with conventional ultrasound features (renal length, parenchymal thickness, resistance index) can improve the predictive value and offer better diagnostic performance in the evaluation of pathological changes in CKD., as it has been shown in a study performed in patients with IgA nephropathy, that had a significantly lower kidney SWS in more severe diseases [56].
One explanation for the different pattern of results and the different relationship between renal stiffness and elastography provided by the different studies could be the fact that histological changes in renal diseases are heterogenous, showing a non-uniform involvement of the compartments of the renal tissue (glomerular, vascular, or tubulointerstitial). However, another explanation could be the fact, that maybe other factors, besides histological changes (renal fibrosis) are involved in influencing renal stiffness.
Besides fibrosis, the stiffness of the renal tissue could be theoretically influenced by urinary pressure, which could be increased in case of urinary obstruction, but again the results of the published studies that are addressing this topic are not consistent. As expected, kidney SWS was increased in children with different degrees of hydronephrosis compared to normal controls, as it has been shown in a study performed on 51 children [57]. But, however, in another study performed on 88 children with vesicoureteric reflux, SWS decreased with the increasing grades of the reflux [58], while a third smaller study (37 children) was not able to discriminate between obstructive and unobstructive hydronephrosis using shear wave elastography [59].
Another factor, besides the structure of the renal tissue and urinary obstruction, that could influence renal tissue stiffness could be renal blood flow. The background for this hypothesis is represented by the fact that the vascularization of the kidney is increased, with 20% of the cardiac outflow running into the kidneys [60, 61].
The relationship between renal blood flow and elastography has been hinted at by experimental data using an
A similar situation to the latter one mentioned above has been reported in a patient with renal vein thrombosis, which led to an increased value of kidney shear wave speed compared to the contralateral kidney [65].
There are also clinical studies that are sustaining the renal blood flow hypothesis. Asano et al. show in a study performed in over 300 CKD patients that increased arterial stiffness, measured through pulse wave velocity (PWV), is associated with a low kidney SWS [60]. These results have been confirmed in another study performed in patients with diabetic kidney disease, that showed a negative, statistically significant correlation of kidney SWS not only with PWV but with the aortic augmentation index as well [66]. This means that in patients in whom there is a progression of arteriosclerosis in the large vessels (high PWV and aortic augmentation index), which leads to a decreased renal blood flow, the kidney SWS is subsequently low.
There are also indirect proofs of the validity of the hypothesis of an existing relationship between renal blood flow and renal stiffness. In patients with gestational hypertension, characterized by renal hypoperfusion, it has been shown that high blood pressure was associated with a low renal elasticity [67].
A study performed in renal transplant recipients showed that interstitial fibrosis/tubular atrophy has no influence on kidney SWS, but adaptive glomerular hyperfiltration leads to an increase in kidney SWS. This observation is in favor of the hypothesis that renal hemodynamics influences renal stiffness [50].
Considering the supposed relationship between renal blood flow and elastography findings, it has been proposed to use pre-procedural elastography to predict the risk of bleeding after renal biopsy, but the results show a low sensitivity, with high specificity for the method [68].
A new experimental elastography-based method that could explain the described results and relationships is two-dimensional time-harmonic ultrasound elastography. When using this method, the patient is placed on a vibration bed that produces continuous vibrations and thus the 2D-SWE elastography covers the entire kidney and is not limited to a superficial ROI [69]. Performing this enhanced elastography Grossman et al. showed that renal SWS decreased significantly in CKD stage 1 (patients with glomerulonephritis) compared to normal controls. Moreover, there was a statistically significant negative correlation with the resistive index, the fact that could underline that renal blood flow is influencing renal stiffness [70].
The decrease of renal blood flow could have a higher influence on renal stiffness, compared to fibrosis, leading to the decrease of kidney SWS. The progression of renal fibrosis, which should increase renal stiffness, is on the other hand associated with a decrease in intrarenal blood flow, leading to opposite effects on renal SWS. This could explain why renal fibrosis is not associated with an increase in renal stiffness in some of the cited studies (Table 1) [41, 55, 56].
Study | Elastography method | Patient population (number, type of subjects) | Histology | SWS in CKD* | |
---|---|---|---|---|---|
1 | Arndt et al. [13] | TE | 57 transplant patients (20 with renal biopsy) | yes | increase |
2 | Syversveen et al. [48] | VTQ | 30 transplant patients | yes | no relationship |
3 | Stock et al. [51] | VTQ | 18 transplant patients | yes | moderate positive |
4 | Grenier et al. [49] | SSI | 43 transplant patients | yes | no relationship |
5 | Sommerer et al. [14] | TE | 164 transplant patients | yes | increase |
6 | Guo et al. [30] | VTQ | 64 CKD patients/327 healthy subjects | no | decrease |
7 | Lukenda et al. [15] | TE | 52 (23 with renal biopsy) | yes | increase |
8 | Hu et al. [41] | VTQ | 163 CKD patients/32 healthy subjects | yes | decrease |
9 | Yu et al. [34] | VTQ | 120 diabetic patients/30 healthy subjects | no | increase |
10 | Asano et al. [60] | VTQ | 309 CKD patients/14 healthy subjects | no | decrease |
11 | Wang et al. [54] | VTQ | 45 CKD patients | yes | no relationship |
12 | Cui et al. [33] | VTQ | 76 CKD patients | yes | increase |
13 | Nakao et al. [47] | TE | 35 transplant patients (27 with renal biopsy) | yes | increase |
14 | Lee et al. [50] | VTQ | 73 transplant patients | yes | no correlation |
15 | Bob et al. [42] | VTQ | 46 CKD patients/58 healthy subjects | no | decrease |
16 | Samir et al. [36] | 2D SWE-SSI | 25 CKD patients/20 healthy subjects | no | increase |
17 | Alan et al. [40] | VTQ | 76 coronary artery disease patients/79 healthy subjects | no | decrease |
18 | Bob et al. [45] | VTQ | 80 diabetic kidney disease patients/84 healthy subjects | no | decrease |
19 | Bilgici et al. [38] | VTQ | 30 CKD patients/38 healthy subjects - pediatric patients | no | decrease |
20 | Bob et al. [55] | VTQ | 20 CKD patients | yes | moderate decrease |
21 | Sasaki et al. [43] | VTQ | 187 CKD patients | no | no relationship |
22 | Yang et al. [35] | VTQ | 90 idiopatic nephrotic syndrome CKD patients/30 healthy subjects | no | increase |
23 | Grosu et al. [39] | Elast PQ | 102 CKD patients/22 healthy subjects | no | decrease |
24 | Liu et al. [46] | Elast PQ | 69 diabetic kidney disease patients/40 diabetic controls | no | increase |
25 | Hu et al. [56] | VTQ | 146 IgA nephropathy patients/39 healthy volunteers | yes | decrease |
26 | Grosu et al. [28] | 2D SWE- GE | 42 CKD patients/50 healthy subjects | no | decrease |
27 | Sumbul et al. [37] | Elast PQ | 125 diabetic, prediabetic patients and controls | no | increase |
28 | Yang et al. [53] | 2D-SWE- SSI | 120 idiopathic nephrotic syndrome - CKD patients | yes | increase |
29 | Lee et al. [31] | VTQ | 73 (biopsies of kidney donors before transplant) | yes | no (tendency of SWS to |
30 | Leong et al. [52] | ElastPQ | 75 CKD patients | yes | increase |
Main published studies on renal elastography.
The terms “increase” or “decrease” are representing a statistically significant change of SWV in CKD compared to healthy subjects, or in more severe CKD compared to less advanced stages.
Shear wave elastography could be an ideal imaging modality to assess CKD because it combines all the well-known advantages of ultrasound examination, which is noninvasive, performed in real time, and does not imply high costs with the possibility to deliver quantifiable results. However, because of the complexity of the kidney architecture and its tissue properties, it seems that the results obtained using renal SWE are affected by numerous confounding elements, a fact that affects the reliability of the method and limits its application to clinical trials [71]. Therefore, it is very important to try to find those methods that could improve the use of SWE (Figure 6).
Factors that influence kidney shear wave speed (SWS).
It has already been shown that combining SWE with other US methods (B-mode ultrasound and color Doppler) increases the prognostic value. The combination of the different ultrasound-based methods could be a step toward the use of multiparametric ultrasound imaging in the assessment of the kidney.
Another step forward could be the use of artificial intelligence. In a study performed in 208 CKD patients machine learning techniques have been used to combine multiple ultrasound characteristics of SWE, B-mode, and color Doppler flow imaging to assess the prognostic value of SWE for kidney tubulointerstitial fibrosis grades among the studied CKD patients. SWE ultrasound fitting machine learning improved the diagnostic performances and also explained the lack of a linear correlation between kidney stiffness and CKD stages [72].
An improvement of the use of renal elastography could emerge from the analysis of raw data of the different systems used. Such an analysis has recently been published by Richard Barr using raw data of different three machines (Siemens, Phillips, and Aixplorer), and the conclusion was that an improvement of processing algorithms could lead to more accurate renal stiffness data from an elastographic system [73]. It is possible that assessing raw data with a new algorithm can overcome the existing limitations of the method, and make kidney elastography a feasible method [17].
Considering all the presented aspects, at the moment, no evidence-based recommendations can be offered for the use of SWE in the assessment of the kidneys [27]. Therefore, more extensive studies are needed to find the place and indication of renal elastography in clinical practice.
The personal research cited and the elastography images inserted in this chapter have been performed with the support of the Center of Elastography of the University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania.
The author declares no conflict of interest.
2D SWE | shear wave speed imaging |
CKD | chronic kidney disease |
eGFR | estimated glomerular filtration rate |
ElastPQ | elastography point quantification |
pSWE | point shear wave elastography |
PWV | pulse wave velocity |
ROI | region of interest |
SWE | shear wave elastography |
SWS | shear wave speed |
VTQ | virtual touch quantification |
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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As a result, any random experiment can be executed in the complex probabilities set C which is the sum of the real probabilities set R and the imaginary probabilities set M. We aim here to incorporate supplementary imaginary dimensions to the random experiment occurring in the “real” laboratory in R and therefore to compute all the probabilities in the sets R, M, and C. Accordingly, the probability in the whole set C = R + M is constantly equivalent to one independently of the distribution of the input random variable in R, and subsequently the output of the stochastic experiment in R can be determined absolutely in C. This is the consequence of the fact that the probability in C is computed after the subtraction of the chaotic factor from the degree of our knowledge of the nondeterministic experiment. We will apply this innovative paradigm to Isaac Newton’s classical mechanics and to prove as well in an original way an important property at the foundation of statistical physics.",book:{id:"11066",slug:"the-monte-carlo-methods-recent-advances-new-perspectives-and-applications",title:"The Monte Carlo Methods",fullTitle:"The Monte Carlo Methods - Recent Advances, New Perspectives and Applications"},signatures:"Abdo Abou Jaoudé",authors:[{id:"248271",title:"Dr.",name:"Abdo",middleName:null,surname:"Abou Jaoudé",slug:"abdo-abou-jaoude",fullName:"Abdo Abou Jaoudé"}]},{id:"46862",title:"Analysis of Balancing of Unbalanced Rotors and Long Shafts using GUI MATLAB",slug:"analysis-of-balancing-of-unbalanced-rotors-and-long-shafts-using-gui-matlab",totalDownloads:8487,totalCrossrefCites:4,totalDimensionsCites:4,abstract:null,book:{id:"3845",slug:"matlab-applications-for-the-practical-engineer",title:"MATLAB",fullTitle:"MATLAB Applications for the Practical Engineer"},signatures:"Viliam Fedák, Pavel Záskalický and Zoltán Gelvanič",authors:[{id:"85462",title:"Associate Prof.",name:"Viliam",middleName:null,surname:"Fedak",slug:"viliam-fedak",fullName:"Viliam Fedak"},{id:"154498",title:"Prof.",name:"Pavel",middleName:null,surname:"Záskalický",slug:"pavel-zaskalicky",fullName:"Pavel Záskalický"},{id:"169849",title:"Dr.",name:"Zoltan",middleName:null,surname:"Gelvanič",slug:"zoltan-gelvanic",fullName:"Zoltan Gelvanič"}]},{id:"65445",title:"Power Flow Analysis",slug:"power-flow-analysis",totalDownloads:5131,totalCrossrefCites:4,totalDimensionsCites:5,abstract:"Power flow, or load flow, is widely used in power system operation and planning. The power flow model of a power system is built using the relevant network, load, and generation data. Outputs of the power flow model include voltages at different buses, line flows in the network, and system losses. These outputs are obtained by solving nodal power balance equations. Since these equations are nonlinear, iterative techniques such as the Newton-Raphson, the Gauss-Seidel, and the fast-decoupled methods are commonly used to solve this problem. The problem is simplified as a linear problem in the DC power flow technique. 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Using firm quarterly data from March 2010 to December 2018, we hypothesized that claims with high positive (negative) slopes are more likely to have large positive (negative) jumps in the future. As such, we expected salient properties of volatile jumps on the written products/contracts. We found that insurance claims for general insurance quoted products cease to be normal. There exist at times some jumps, especially during holidays and weekends. Such jumps are not healthy to the capital structures of firms, as such they need attention. However, it should be noted that gaps or jumps (unless of specific forms) cannot be hedged by employing internal dynamic adjustments. This means that, jump risk is non-diversifiable and such jumps should be given more attention.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha"},{id:"81471",title:"Semantic Map: Bringing Together Groups and Discourses",slug:"semantic-map-bringing-together-groups-and-discourses",totalDownloads:21,totalDimensionsCites:0,doi:"10.5772/intechopen.103818",abstract:"This chapter presents a multivariate analysis method which is developed in two steps using a combination of Hierarchical cluster analysis (HCA) and Factorial Correspondence Analysis (AFC). To explain and describe the steps of the method, we use an application example on a survey dataset from young students in Thessaloniki trying to investigate their behavioral profiles in terms of political characteristics and how these may be affected about their attendance to a civic education course offered by the Political Science department in the Aristotle University of Thessaloniki. The method is explained step by step on this example serving as a manual of its application to the researcher. HCA assigns subjects into cluster membership variables and in the next stage, these new variables are jointly analyzed with AFC. Correspondence analysis manages to extract the dimensions of the phenomenon in the study, explaining the inner antithesis between the categories but also giving the opportunity to visualize the information in a two-dimensional space, a semantic map, making interpretation more comprehensive. HCA is then applied again to the AFC’s coordinates of the categories constructing profiles of subjects, assigning them to the categories of the variables.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"Theodore Chadjipadelis and Georgia Panagiotidou"},{id:"79491",title:"Fuzzy Perceptron Learning for Non-Linearly Separable Patterns",slug:"fuzzy-perceptron-learning-for-non-linearly-separable-patterns",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.101312",abstract:"Perceptron learning has its wide applications in identifying interesting patterns in the large data repositories. While iterating through their learning process perceptrons update the weights, which are associated with the input data objects or data vectors. Though perceptrons exhibit their robustness in learning about interesting patterns, they perform well in identifying the linearly separable patterns only. In the real world, however, we can find overlapping patterns, where objects may associate with multiple patterns. In such situations, a clear-cut identification of patterns is not possible in a linearly separable manner. On the other hand, fuzzy-based learning has its wide applications in identifying non-linearly separable patterns. 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The problems related to the number of clusters and the configuration of observations are addressed via Markov Chains Monte Carlo (MCMC) sampling method. Gibbs sampler is implemented to draw observations from the related full conditionals. As a concrete example, the cocaine use data are analyzed to illustrate the merits of the proposed methodology.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"Ye-Mao Xia, Qi-Hang Zhu and Jian-Wei Gou"},{id:"78846",title:"Clustering Algorithms: An Exploratory Review",slug:"clustering-algorithms-an-exploratory-review",totalDownloads:146,totalDimensionsCites:0,doi:"10.5772/intechopen.100376",abstract:"A process of similar data items into groups is called data clustering. Partitioning a Data Set into some groups based on the resemblance within a group by using various algorithms. Partition Based algorithms key idea is to split the data points into partitions and each one replicates one cluster. The performance of partition depends on certain objective functions. Evolutionary algorithms are used for the evolution of social aspects and to provide optimum solutions for huge optimization problems. In this paper, a survey of various partitioning and evolutionary algorithms can be implemented on a benchmark dataset and proposed to apply some validation criteria methods such as Root-Mean-Square Standard Deviation, R-square and SSD, etc., on some algorithms like Leader, ISODATA, SGO and PSO, and so on.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"R.S.M. Lakshmi Patibandla and Veeranjaneyulu N"},{id:"78463",title:"Clustering by Similarity of Brazilian Legal Documents Using Natural Language Processing Approaches",slug:"clustering-by-similarity-of-brazilian-legal-documents-using-natural-language-processing-approaches",totalDownloads:157,totalDimensionsCites:1,doi:"10.5772/intechopen.99875",abstract:"The Brazilian legal system postulates the expeditious resolution of judicial proceedings. However, legal courts are working under budgetary constraints and with reduced staff. As a way to face these restrictions, artificial intelligence (AI) has been tackling many complex problems in natural language processing (NLP). This work aims to detect the degree of similarity between judicial documents that can be achieved in the inference group using unsupervised learning, by applying three NLP techniques, namely term frequency-inverse document frequency (TF-IDF), Word2Vec CBoW, and Word2Vec Skip-gram, the last two being specialized with a Brazilian language corpus. We developed a template for grouping lawsuits, which is calculated based on the cosine distance between the elements of the group to its centroid. The Ordinary Appeal was chosen as a reference file since it triggers legal proceedings to follow to the higher court and because of the existence of a relevant contingent of lawsuits awaiting judgment. After the data-processing steps, documents had their content transformed into a vector representation, using the three NLP techniques. We notice that specialized word-embedding models—like Word2Vec—present better performance, making it possible to advance in the current state of the art in the area of NLP applied to the legal sector.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"Raphael Souza de Oliveira and Erick Giovani Sperandio Nascimento"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. 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After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. 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\r\n\tSustainable development focuses on linking economic development with environmental protection and social development to ensure future prosperity for people and the planet. To tackle global challenges of development and environment, the United Nations General Assembly in 2015 adopted the 17 Sustainable Development Goals. SDGs emphasize that environmental sustainability should be strongly linked to socio-economic development, which should be decoupled from escalating resource use and environmental degradation for the purpose of reducing environmental stress, enhancing human welfare, and improving regional equity. Moreover, sustainable development seeks a balance between human development and decrease in ecological/environmental marginal benefits. Under the increasing stress of climate change, many environmental problems have emerged causing severe impacts at both global and local scales, driving ecosystem service reduction and biodiversity loss. Humanity’s relationship with resource exploitation and environment protection is a major global concern, as new threats to human and environmental security emerge in the Anthropocene. Currently, the world is facing significant challenges in environmental sustainability to protect global environments and to restore degraded ecosystems, while maintaining human development with regional equality. Thus, environmental sustainability with healthy natural ecosystems is critical to maintaining human prosperity in our warming planet.
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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. 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Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. Dr. Şentürk serves as the editorial board member of several international journals.",institutionString:"Ağrı İbrahim Çeçen University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ağrı İbrahim Çeçen University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:320,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/73496",hash:"",query:{},params:{id:"73496"},fullPath:"/chapters/73496",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()