Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
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This achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
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We are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
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Thank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
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1. Introduction
Rivers in Lebanon are usually considered as the most significant water resources, as well as they are one of the known heritage sites and distinguished landscape. They show dense networks since there are 14 rivers located in the area of 10,452 km2. Therefore, the estimated total annual discharge is about 3452 million m3 where there is about 20% of this discharge goes into the Transboundary Rivers, therefore, the net discharge from the Lebanese rivers is approximately 2800 million m3/year.
The average annual discharge from these rivers is about 247 million m3, which is low enough if compared with international rivers, as an example, this volume of water is equivalent to the discharge from the Nile River in one day. There is also an argument about the exact number of rivers in Lebanon notably that not all of the 14 rivers, which are discharging water all year long as it was the case in the past, and this gives the first indicator about the current bad status on these rivers. Thus, the adoption of this number (i.e. 14) has been derived from the morphometric characterization basis and catchment shapes of the existing perennial watercourses, even though this conflicts with their hydrology where water flow is now almost intermittent.
There is remarkable hydrologic feature that characterizes the Lebanese rivers where all of them are almost controlled by the rugged topography, and then distributed within the three geomorphological units of Lebanon (i.e. Mount-Lebanon, Bekaa Plain and the Anti-Lebanon). Hence, Lebanon with its small area represents as a regional hydrologic junction where water flows into three regional directions. These are regional flows: 1) northward to comprise a tributary of the Orates River Flow System, 2) southward forming a major tributary for Jordan River Flow System and 3) eastward where the Lebanese Coastal Rivers System flow to the Mediterranean Sea [1].
Rivers in Lebanon have diverse orientations of distribution on terrain surfaces, and more specifically they are characterized by different flow directions and dimensions. Therefore, these rivers can be classified as follows:
Coastal Rivers: These are 10 rivers in Lebanon span along Mount-Lebanon where they have originated from, and then trending from east and discharge in the Mediterranean Sea (Figure 1), and then described as “Coastal rivers”. These rivers are essentially fed from the snowmelt. The coastal rivers are relatively short where the longest one is El-Awali River which is about 61 km (curved). In addition, these rivers have nearly similar basin characteristics where the channel slope is relatively high and averages at 35–40 m/km, and this makes water flows rapidly between 5- and 10 km/hour in average [2]. This in turn results water loss into the sea.
Inner Rivers: Other than the 10 coastal rivers, there are 4 rivers in Lebanon that are characterized by diverse catchment morphometry and hydrology including mainly the flow direction and discharge regime. One of these rivers (i.e. El-Kabir River) is originated from the most northern part of Lebanon and outlets into the Mediterranean Sea (Figure 1); another two rivers (i.e. Al-Assi River and Litani River) are originated from the Bekaa Plain where the first one flows northward to Syria and the second flows southward and then diverted towards the sea within the Lebanese territory. The fourth river (i.e. Hasbani-Wazzani River) is originated from Jabal Hermoun and then spans southward comprising the highest channel slope (40 m/km) of the four rivers. Except the Litani River, the other three rivers are Transboundary water resources.
Figure 1.
Rivers of Lebanon [1].
2. Watersheds of the Lebanese Rivers
Elaborating the dimensions and mapping of drainage systems, including the catchment and the streams inside, is usually applied as a primary phase for detailed hydrological analysis and surface water assessment. Therefore, the geometric and morphometric analysis are utmost significant in watershed management to presume, for example, site suitability for surface water accumulation and harvesting, agricultural projects, dams’ construction, hydro-power sites, etc.
Drainage systems of Lebanon including rivers were extracted directly from the stereoscopic satellite images (i.e. SRTM DEM) where digital elevation models were generated by magnifying the pixel details, and then slopes were extracted to determine flow directions and then stream delineation. Therefore, the digital extraction of drainage systems enabled calculating a number of geometric and morphometric measurements.
2.1 Geometry of the Lebanese rivers
Geometric measurements represent the calculations of the variables for the boundary of watershed (or catchment), and this will be totally separated from the properties of the streams (primary or secondary) included in the catchment. In this view, catchments with relatively large areas are usually subdivided into sub-catchments, which is dependent of the purpose of study applied.
For Lebanon, the area of rivers catchments is small and averaging about 250 km2 for the coastal rivers if excluding the Litani River, which is an inner-coastal river. Hence, the largest area belongs to this river (i.e. Litani) and the smallest one belongs to Siniq River (Figure 1 and Table 1).
Geometric measurements of the Lebanese rivers’ catchments [1].
Catchment area within Lebanon.
R = River.
Basin maximum length (Bl): This represents the maximum straight length of the catchment where it extends almost parallel to the primary watercourse, and it reflects the topographic orientation of a catchment
BL is a function of water arrival time to reach the outlet, and thus it controls the time of leakage, evaporation, and transpiration Table 1 shows the maximum length of catchments of the Lebanese rivers
Basin width (Bw): The ratio of length of a catchment to its width significantly affects water flow to the outlet, thus when the difference between the length and width of a catchment is relatively low, that means the flow will be more regular and takes more time than it when this difference is high. For Lebanon, the Bw of rivers catchments are shown in Table 1.
Elongation Index (Ei): This represents the ratio between the diameter of the circle with the same area (A) as the catchment, and the distance between the maximum two points (Bl) in the catchment [3]. It is expressed by the formula:
Ei=2√ABl√πE1
Table 1 shows the calculated Ei for the catchments of the Lebanese rivers. According to Schumm [3], Ei is: < 0.5, 0.5–0.7, 0.7–0.8, 0.8–0.9 and 0.9–1 for more elongated, elongated, less elongated, oval and circular; respectively.
Form Factor (Ff): It is the numerical index used to determine ratio of the basin area to square of the basin length [1]. It is a function of the flow energy in the catchment. Thus, form factors for the catchments of the Lebanese rivers are shown in Table 1.
Hence, Ff must be less than 0.7854 [4]. Therefore, smaller Ff value indicates more elongated, while high Ff value experience larger peak flows of shorter duration. According to Horton (1932) form factor is expressed as:
Ff=AL2E2
Relief gradient (Rr): This is the ratio between the altitude at the highest and lowest points on the catchment, and it is calculated according to following formula [5]:
These represent measurements for the dimensions, orientation and the connection between different streams in a catchment [6]. Thus stream morphometry evidences the origin and evolution of drainage networks, geomorphology and geology of the underlying stratum. For this reason, stream morphometry controls water flow regime and mainly the flow energy. Table 2 shows the main morphometric calculations for the streams (primary and secondary) in the Lebanese rivers’ catchments.
No
Catchment
Length (km)
Ss
Cs
Dd
Mr
Tt
Straight
Curved
m/km
—
S/km2
%
—
1
El-Kabir R.
46
59
17
25
3.00
78
3.77
2
Al-Bared R.
37
49
13
14
1.00
76
2.75
3
Abou-Ali R.
42
54
54
46
1.75
78
6.95
4
Ej-Jouz R.
33
37
27
44
2.40
89
5.51
5
Ibrahim R.
44
50
63
45
5.30
88
16.30
6
El-Kaleb R.
35
41
66
45
6.10
85
17.25
7
Beirut R.
48
58
52
50
5.80
83
14.89
8
Ed-Damour R.
45
54
51
46
5.30
83
18.15
9
El-Awali R.
50
61
36
44
4.35
82
10.90
10
Siniq R.
18
21
7
9
2.35
86
7.54
11
Ez-Zahrani R.
36
41
8
13
2.10
88
8.16
12
Litani R.
163
174
5
8
0.84
83
0.54
13
Al-Assi R.
31
33
19
21
1.27
94
13.03
14
Hasbani-Wazzani R.
22
25
14
11
1.14
88
5.06
Table 2.
Major morphometric measurements of the Lebanese rivers’ catchments [1].
Mean stream slope (Ss): It is the difference between the altitude at the source and the altitude at the outlet with respect to the total stream length. Thus, higher Ss results high flow rate along the primary stream in the catchment and vice versa. The following formula represents Ss [7]:
Mean catchment slope (Cs): This is calculated by dividing the difference in elevation between points at defined lengths of the catchment (e.g. 0.85 L towards the upper and 0.10 L near the lower part of the catchment) over the length of the catchment. Hence, Cs is expressed by the following formula [8]:
Drainage density (Dd): This represents the degree of streams congestion in an identified area of the catchment. Thus, it is calculated by dividing the total length of streams within the identified area in the catchment. Hence, streams with high density indicate lower permeability of terrain surface if compared with lower density stream [9]. Ds is calculated according to the following formula:
Dd=ΣLtotal ofallstream segmentsAarea of the basinE6
Meandering ratio (Mr): It is ratio between straight and curved length of the primary stream in the catchment [2]. Therefore, higher Mr ratio reflects low run-off energy and higher sedimentation rate. Mr can be calculated as follows:
Mr=LstraightLcurvedE7
Texture topography (Tt): This evidences the ability of a terrain to infiltrate water as it is controlled by rock types and structures in the catchment. It is calculated as the total number of streams (Ns) of all order in a basin per perimeter (Bp) of the basin [10]. Hence, Tt is calculated by the following equation [11]
Tt=∑Ns/BpE8
Smith [11] classified the texture topography as: very coarse (<2), coarse (2 to 4), moderate (4 to 6), fine (6 to 8) and very fine (>8).
3. Volumetric measures of the Lebanese rivers
It is significant to calculate the volume of water that enters the drainage system of rivers. This assists in characterizing the catchment ability to capture and outlet water. This requires elaborating quantitative analysis in the each catchment, where the volume of precipitated water and discharged water are measured.
For the precipitated water, data were collected from the available meteorological ground stations, as well as form remotely sensed products, with emphasis to Tropical Rainfall Mapping Mission - TRMM [12]; Climate Hazards group Infrared Precipitation with Stations - CHIRPS [13]; and from National Oceanographic Data Center – NOAA [14]. While, the discharge from the Lebanese rivers is periodically measured by the Litani River Authority (LRA) [15]. Therefore, water volume enters and outlet, along rivers, from each watershed was calculated as shown in Table 3.
No.
Catchment
Area (A)
Rainfall (R)
Discharge (D)
D/R
R/A
km2
Mm3/year
%
Mm3/km2
1
El-Kabir R.*
303
260
222
—
0.38
2
Al-Bared R.
284
225
165
73
0.79
3
Abou-Ali R.
482
505
365
72
1.04
4
Ej-Jouz R.
196
125
80
64
0.64
5
Ibrahim R.
326
380
495
131
1.16
6
El-Kaleb R.
237
330
225
66
1.39
7
Beirut R.
216
260
100
38
1.20
8
Ed-Damour R.
333
335
255
76
1.00
9
El-Awali R.
291
320
280
88
1.09
10
Siniq R.
102
100
60
60
0.98
11
Ez-Zahrani R.
140
145
200
137
1.03
12
Litani R.
2110
2078
360
17
0.98
13
Al-Assi R.*
1930
1254
420
—
0.65
14
Hasbani-Wazzani R.*
645
598
225
—
0.89
Table 3.
Volume of precipitated water discharged water from the Lebanese rivers’ catchments [1].
*Transboundary River
Table 3 shows that the average volume water enters the catchments is about 480 million m3/year, and the average discharge is approximately 247 million m3/year. This indicates that the Lebanese rivers are discharging only about 51% of the precipitated where the rest 49% goes to the evapotranspiration and for groundwater recharge [1].
4. Water pollution in rivers
It is estimated that in Lebanon, more than 50% of water resources are under physiochemical and biological contamination, and rarely a source of water in Lebanon is pure [16]. Lately, the problem of water quality deterioration has become one of the major is striking challenges that acts on the national level, and it severely hurts human life. This includes mainly the pollution of surface and then followed by groundwater resources.
This unfavorable problem is being increased by the absence of the controls and therefore, disposal of liquid and solid wastes (i.e. industrial, municipal and agronomical wastes) is widespread, notably in river courses and streams. Hence, the bad geo-environmental situation, due to water pollution, added a challenging issue for the water sector in Lebanon, while it is surprising that no effective actions have been taken by the concerned governmental bodies and even there is unethical behavior by some inhabitants in different regions of the country.
The Litani River, the largest river in Lebanon, gives a typical example on water pollution in the country. This rivers, which includes more than 370.000 people in 246 towns and encompasses 174 km length, has been lately witnessing intensive pollution pressure. This implies the river Couse and its reservoir (i.e. Qaraaoun Reservoir). Therefore, it was described as “Death of a River” [17]. In this respect, pollution sources were determined including direct dumping of huge amounts of solid wastes and high volume of sewage water into the river course and its tributaries, excessive use of fertilizers and well as the presence of many landfills within the catchment of the river and thus acting on groundwater purity.
Many surveys and studies have been done to investigate water quality in Lebanon where some of them aimed also at identifying the sources of pollution. The largest number of these studies were either applied to selective regions, or sometime they were applied for a limited time period specific, while other studies investigated only one aspect of pollution (e.g. microbiological pollution).
It is still a paradox that even with the large number of studies, nothing has been improved yet in regard to water quality in all resources; besides the pollution level in being continuously increased. Moreover, no effective management plans have been addressed to resolve the problem, and if they are proposed/exist, they remain propositions or without creditable implementation.
There are many examples can be illustrated to expose the current situation on the deteriorated water quality in Lebanon. Below are some example [18]:
The analysis of selective water samples from the Litani River shows:
Nitrite (NO2) 19 ppm (max. 0.1 ppm)
Chromium (Cr3+) 0.27 (max. 0.05 ppm)
Staphylococcus 8750 (0 in 100 ml)
Total coliform 183,000 (0 in 100 ml)
Fecal coliform 180,000 (0 in 250 ml).
The analysis of water quality the Qaraaoun Reservoir shows [19, 20, 21]:
Carlson trophic state index 66 to 84 (CTSI max. 40).
The analyzed samples of groundwater analysis in different boreholes located in the Bekaa Plain showed that Nitrate (NO3) concentration exceeded 300 mg L−1 [22].
The analyzed bottled water which were taken form 48 major water companies in Lebanon showed that approximately 80% were contaminated either chemically or biologically or combination of both [23].
Due to its significance and the resulted severe impact on human health and even life, there are some implementations done for waste disposal management, and thus several national and international projects were applied. Moreover, field campaigns, capacity building, inter-ministerial committees and business plans were established to identify the required measures and secure water quality and the existing ecosystems, but no enhancement in this concern could be touched yet [17].
5. Uncontrolled water pumping
In the view of shortened water supply besides an exacerbated demand, inhabitants are always searching for any available sources of water to compensate the difference between supply and demand. This primarily accounts the ease and the low-cost of exploitation of these sources. Hence, rivers are the most applicable resources to be invested in Lebanon, notably that these rivers and their major tributaries are widespread over short distances between urban clusters and among the arable lands where water is competitive. Hence, many rivers’ tributaries are only few kilometers from each other.
In addition to this geographic aspect of the Lebanese rivers, there is no consolidated and effective environmental controls to regulate the behavior of people towards the exploitation of water from rivers. This can be also attributed to many other reasons including mainly the political situation in the country. Therefore, unfavorable works are widespread in all the Lebanese rivers, and illegal water abstraction from rivers plus dumping of liquid and solid wastes are commonly observed. These works can be summarized as follows:
Direct water pumping from rivers and the surrounding springs where this pumping does not follow and control or measuring approaches (i.e. illegal), and this is very common in upstream regions of the Lebanese rivers. The largest part (>90%) of the pumped water goes to irrigation (Example in Figure 2).
Uncontrolled water use from rivers where several private water systems are connected with rivers, and then conveying water along private-owned canals for irrigation. These canals can be for hundreds of meters long.
Chaotic water abstraction whether from the recharge zones of rivers, where rivers receive their water from, or from the recharge zones of springs and groundwater aquifers which in turn replenish rivers.
Figure 2.
Illegal pumping of water from rivers in Lebanon, a common observation.
6. Transboundary rivers
In spite of the small surface area of Lebanon (i.e. 10,452 km2), the geography of the country makes its water resources shared with the neighboring regions. Therefore, about 2631 km2 of Lebanon’s surface area constitutes shared groundwater reservoirs with the neighboring regions, and this is equal to approximately 25% of the Lebanese area [2]. In addition, there are approximately 2878 km2 (27.5%) of Lebanon’s surface area comprises basins for transboundary rivers with the riparian regions. Thus, Lebanon contributes with major tributaries for three transboundary rivers [2]:
Al-Kabir River (222 million m3/year from Lebanon): It almost represents the northern international boundary of Lebanon with Syria, and it encompasses a catchment area of 972 km2 where 303 km2 are in Lebanon.
Orontes River (420 million m3/year from Lebanon): One of its major tributaries is originated from Lebanon and then named as Al Assi River. It is shared with Syria and Turkey with a total catchment area of 25,300 km2 where 1930 km2 are located in Lebanon.
Jordan Rivers (225 million m3/year from Lebanon): In Lebanon the Hasbani-Wazzani River represents one of the primary tributaries of Jordan River which is shared with Syria, Jordan and Israel. The river, which is under frequent geo-political conflicts, has a total catchment area of about 18,425 km2, only 645 km2 of them are in Lebanon.
There are only 210 million m3 of water which is used by Lebanon from shared water resources of the country [2], and this volume constitutes water pumped from transboundary rivers, as well as the estimated water abstracted from dug wells in shared groundwater aquifers). This volume represents only about 15% of the total volume of these resources.
In the lack to proper management of these shared water resources; however, Lebanon loses a significant portion of its water. According to Shaban and Hamzé [2], if Lebanon adopted integrated and appropriate management approaches for its shared water resources, and then work in the direction of utilizing around 50% of these resources; thus, a water volume of about 700 million m3 can be added to the budget of water in Lebanon.
If this volume is allocated to consumers in the country; therefore, approximately 175 m3 per capita (i.e. equivalent to about 80% of water demand per capita) will be added to water supply. Whereas, the benefit of about 60% of shared water in Lebanon; will totally provide the water demand per capita. This in turn catalysis the adoption of these resources which can be done by following integrated management strategies of these resources.
7. Dispute on dams construction
Lebanon is characterized by mountain topography where acute sloping terrain is dominant, and the majority of precipitation (rainfall and snow) accumulates on the elevated areas and then water rapidly flows along these slopes. The journey of water flow from mountains to the sea takes short time interval which was estimated approximately as few hours, notably that the average distance of flow does not exceed few tens of kilometers.
Therefore, the flow of water from the Lebanese mountains is considered as a major aspect of water loss and water outlet into the sea before any significant investment. Therefore, water harvesting should adopted as an alternative solution to tap water along the Lebanese rivers instead of water loss. Hence, construction of dams will be an optimal solution.
There are dams constructed in Lebanon along some rivers and major tributaries, but they are still of small-scale dams, except the ones of Qaraaoun and Shabrouh dams, which have capacity of 220 and 11 million m3; respectively. In this regard, the Ministry of Energy and Water (MoEW) obtained a long-term plan for surface water development within the horizon of 2030 where 18 dams are proposed.
It is unlikely that the Lebanese administration and public finance can accomplish the planned long-term plan for constructing the proposed dams and lakes before 2030. Reasons behind postpone/or obstruction of dams construction in Lebanon are tremendous. One of these reasons is the dispute on dams’ construction, and more certainly the believe that the topography and geology of Lebanon are not suitable for dam’s construction; in particular the seismic setting of Lebanon does not assure the stability of dams [1]. Therefore, there is always debate on dams’ construction in Lebanon. Lately, a problem has been existed even on the political level where the two proposed dams of Bisri and Janeh regions have been come to the implementation phase. Thus, there is of postponing to start working on these dams due to the existed conflicts about their location suitability.
8. Conclusion
Rivers in Lebanon are compose the veins of agricultural development, notably that the largest portion of water supply is delivered from rivers, as well as rivers constitute about 42% of water resources in Lebanon besides 32% from groundwater and the rest 26% is from other sources and mainly springs. However, these estimates are still rough and the water cycle in Lebanon can be considered as a comprehensive cycle where all elements of water journey are included. Thus, rivers feed groundwater, and the later replenish spring and so on.
Rivers in Lebanon discharge about 2800 million m3 per year, which a significant part of the water balance in Lebanon. Nevertheless, only 25% (or even less) of this amount is exploited and the rest is either lost to sea or shared with the neighboring regions.
The exploitation of water from these rivers is almost chaotic and illegal, notably for irrigation which consumes more than 70% of water in Lebanon. In addition to domestic and industrial uses, water from rivers is also used for hydro-power generation and it contributes to approximately 20% of electricity needs for the entire country.
There are several threats existed lately on these rivers and they include natural and man-made threats. Hence, the average annual discharge rate in rivers has been sharply decreased and some rivers showed decline in the discharge reach up to 60% of its normal discharge rate. This is attributed either to the direct pumping from these rivers or the over pumping form the feeding zone for springs and groundwater aquifers. In addition, the changing hydrologic regimes of the terrain surface plays a major role in controlling the amount of water in rivers [1].
Moreover, pollution is a major problem in all Lebanese rivers and rarely a river in Lebanon is found with pure water. Thus, outfalls from wastewater (e.g. sewages, domestic, etc.) sources and delivered towards rivers. This made some rivers, like the Litani River, as a source of contamination and diseases became widespread in the proximity of its tributaries. In addition, the physiochemical and bacteriological analysis of water and sediments in many of these rivers showed contamination exceeds several times the accepted standards.
The solution for the Lebanese rivers implies adopted an integrated management of river’ water. This can be built in the context of a national water strategy where assessment and monitoring must be continuously applied, and this can be consolidated by creating environmental legislations and laws devoted for water in rivers of Lebanon.
\n',keywords:"stream flow, over pumping, climate change, pollution, dams",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73655.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73655.xml",downloadPdfUrl:"/chapter/pdf-download/73655",previewPdfUrl:"/chapter/pdf-preview/73655",totalDownloads:293,totalViews:0,totalCrossrefCites:1,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:54,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"June 29th 2020",dateReviewed:"September 22nd 2020",datePrePublished:null,datePublished:"February 17th 2021",dateFinished:"October 17th 2020",readingETA:"0",abstract:"Lebanon is known by tremendous water resources, and this has been often viewed from the considerable number of rivers (i.e. 14 rivers). These rivers are characterized by small catchments and short length. The estimated average annual discharge from these rivers is approximately 2800 million m3. Due to the sloping terrain of Lebanon; however, it was estimated that more than 75% of water from rivers is unexploited it mainly outlets into the sea. The majority of water use from the Lebanese rivers implies domestic, agriculture, as well as some other rivers are used for hydro-power generation where they contribute by about 20% of electricity needed for Lebanon. Lately, and added to water pollution, there is abrupt decline in the discharge from these rivers estimated to more than 60% of their average annual discharge. This unfavorable situation is attributed, in addition to the changing climate, to the anthropogenic interference is the most affecting one and it is represented by over pumping from these rivers and form the recharge zone for groundwater and springs that feed these rivers. This chapter aims at introducing a discussion on the existed challenges on the Lebanese rivers and the proposed and their impact.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73655",risUrl:"/chapter/ris/73655",book:{id:"9864",slug:"hydrology"},signatures:"Amin Shaban",authors:[{id:"75122",title:"Prof.",name:"Amin",middleName:null,surname:"Shaban",fullName:"Amin Shaban",slug:"amin-shaban",email:"geoamin@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"National Council for Scientific Research",institutionURL:null,country:{name:"Lebanon"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Watersheds of the Lebanese Rivers",level:"1"},{id:"sec_2_2",title:"2.1 Geometry of the Lebanese rivers",level:"2"},{id:"sec_3_2",title:"2.2 Morphometry of the Lebanese Rivers",level:"2"},{id:"sec_5",title:"3. Volumetric measures of the Lebanese rivers",level:"1"},{id:"sec_6",title:"4. Water pollution in rivers",level:"1"},{id:"sec_7",title:"5. Uncontrolled water pumping",level:"1"},{id:"sec_8",title:"6. Transboundary rivers",level:"1"},{id:"sec_9",title:"7. Dispute on dams construction",level:"1"},{id:"sec_10",title:"8. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Shaban, A. Water Resources of Lebanon. Springer Science Publisher. 2020. DOI: 10.1007/978-3-030-48717-1. 229 pp'},{id:"B2",body:'Shaban, A., Hamzé, M. Shared water resources of Lebanon, Nova Publishing, NY. 2017. DOI:10.1007/978-3-030-48717-1. p 150'},{id:"B3",body:'Schumm, S. The elevation of drainage systems and slopes in bad-lands at Perth Amboy, New Jersey. Geol. Soc. Amer. Bull., Vol. 67. 1956. pp. 597-646'},{id:"B4",body:'Horton E. Drainage-basin characteristics. Trans. American Geophysical Union. 1932;13:350-361'},{id:"B5",body:'Pike, R., Wilson, S. Elevation-relief ratio. Hypsometric Integral and Geomorphic Area-Altitude Analysis.” GSA Bull. 1971. 82: 1079-1084'},{id:"B6",body:'Al Saud, Mashael.. Use of Remote Sensing and GIS to Analyze Drainage System in Flood Occurrence, Jeddah - Western Saudi Coast (Chapter in Book entitled: Drainage Systems. InTech Open Science. Croatia. 2012. 139-164pp. ISBN13: 978-953-51-0243-4'},{id:"B7",body:'Raven, P., Holmes, N., Naura, M., Dawson, F. Using river habitat survey for environmental assessment and catchment planning in the U.K. Hydrobioloigia. 2000. Vol. 422(0):359–367'},{id:"B8",body:'Morisawa, M. Geomorphology Laboratory Manual, John Wiley & Sons Inc. N.Y. 1976. pp.1-253'},{id:"B9",body:'Shaban, A., Bou Kheir, R; Khawlie, M., Froidefond, J, Girard, M-C. Caractérisation des facteurs morphométriques des réseaux hydrographiques correspondant aux capacités d’infiltrations des roches au Liban occidental. Zeitschrift fur Geimorphologie. 2004. Vol. 48/1, pp 79-94'},{id:"B10",body:'Horton R. Erosional developments of streams and their drainage basins: Hydro-physical approach to quantitative morphology. Geological Society of America Bulletin. 1845;56:275-370'},{id:"B11",body:'Smith K. Standards for grading texture of erosional topography. American Journal of Science. 1950;248:655-668'},{id:"B12",body:'TRMM (Tropical Rainfall Mapping Mission). Rainfall archives. NASA. 2015. <http:// disc2.nascom.nasa.gov/Giovanni/tovas/TRMM_V6.3B42.2.shtml>'},{id:"B13",body:'CHIRPS (Climate Hazards Group InfraRed Precipitation with Station data). 2017. Available at: http://chg.geog.ucsb.edu/data/chirps/'},{id:"B14",body:'NOAA (National Oceanographic Data Center). Lebanon Climatological Data. Library. 2013. Available at: http://docs.lib.noaa.gov/rescue/data_rescue_lebanon.html'},{id:"B15",body:'LRA (Litani River Authority). Rivers discharge records database.2017. Unpublished Report'},{id:"B16",body:'Shaban, A. Physical and Anthropogenic Challenges of Water Resources in Lebanon. Journal of Scientific Research and Reports. 2014. Vol.3 Issue 3. 2014. 164-179'},{id:"B17",body:'Shaban, A., Hamzé, M. The Litani River, Lebanon: An Assessment and Current challenges. Springer International Publisher. 2018. 179 p. DOI: 10.1007/978-3-319-76300-2'},{id:"B18",body:'Nehme, N., Haidar, C. The Physical, and Chemical and Microbial Characteristics of Litani River Water. Chapter in Book entitled: The Litani River, Lebanon: An Assessment and Current challenges. 2018. Springer. 179 p'},{id:"B19",body:'Fadel A, Atoui A, Lemaire BJ, Vinçon-Leite B, Slim K. Environmental factors associated with phytoplankton succession in a Mediterranean reservoir with a highly fluctuating water level. Environ. Monit. Assess. 2015;187:633 https://doi.org/10.1007/s10661-015-4852-4'},{id:"B20",body:'Fadel, A., Faour, G., Slim, K., 2016. Assessment of The trophic state and Chlorophyll-a concentrations using Landsat OLI in Karaoun reservoir , Lebanon. Leban. Sci. Journal, 17, 130–145. 2016. https://doi.org/10.22453/LSJ-017.2.130145'},{id:"B21",body:'Fadel, A. , Slim, K. Evaluation of the Physicochemical and Environmental Status of Qaraaoun Reservoir. Chapter in Book entitled: The Litani River, Lebanon: An Assessment and Current challenges. 2018. Springer. 179 p'},{id:"B22",body:'Darwich T, Atallah T, Baydoun S, Jomaa I, Kassem M. Environmental risk of nitrate accumulation in the soil-groundwater system in Central Bekaa Valley, Lebanon. 2014. International Conference on: The Water-Food-Energy-Climate Nexus in Global Drylands, Rabat, Morocco, 12-13 June 2014'},{id:"B23",body:'CPA (Consumer Protection Association). Analysis of water quality in bottled water of Lebanon. 2018. Unpublished Report. 7 pp'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Amin Shaban",address:"geoamin@gmail.com",affiliation:'
National Council for Scientific Research, Beirut, Lebanon
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Study",slug:"flood-management-in-china-the-huaihe-river-basin-as-a-case-study",signatures:"Qian Mingkai and Wang Kai",authors:[{id:"201582",title:"Dr.",name:"Kai",middleName:null,surname:"Wang",fullName:"Kai Wang",slug:"kai-wang"},{id:"204506",title:"Prof.",name:"Mingkai",middleName:null,surname:"Qian",fullName:"Mingkai Qian",slug:"mingkai-qian"}]},{id:"55569",title:"Two-Dimensional Hydraulic Modeling and Geotechnical Analysis of Earthen Regulation Dams Located at Arroyo Las Viboras Watershed in a Major Transboundary Mexico-USA Metroplex: How an Ordinary Rain Event Caused Major Damage Related to Extraordinary Flooding",slug:"two-dimensional-hydraulic-modeling-and-geotechnical-analysis-of-earthen-regulation-dams-located-at-a",signatures:"Oscar Sotero Dena Ornelas, Diane Irene Doser, Oscar Fidencio\nIbañez Hernández, Griselda Janeth Obeso Cortez and Miguel Angel\nGaldean Vega",authors:[{id:"202254",title:"Dr.",name:"Oscar",middleName:null,surname:"Dena",fullName:"Oscar Dena",slug:"oscar-dena"},{id:"203459",title:"M.Sc.",name:"Griselda",middleName:"Janeth",surname:"Obeso Cortez",fullName:"Griselda Obeso Cortez",slug:"griselda-obeso-cortez"},{id:"207612",title:"Dr.",name:"Diane Irene",middleName:null,surname:"Doser",fullName:"Diane Irene Doser",slug:"diane-irene-doser"}]},{id:"55735",title:"Understanding Flood Risk Management in Asia: Concepts and Challenges",slug:"understanding-flood-risk-management-in-asia-concepts-and-challenges",signatures:"Saleem Ashraf, Muhammad Luqman, Muhammad Iftikhar, Ijaz\nAshraf and Zakaria Yousaf Hassan",authors:[{id:"202027",title:"Dr.",name:"Muhammad Saleem",middleName:null,surname:"Ashraf",fullName:"Muhammad Saleem Ashraf",slug:"muhammad-saleem-ashraf"}]},{id:"55205",title:"Analysis of the Influence of the 2007–2008 La Niña Events, Land Use, and Dam Management Modes on the 2008 Spring Freshet Characteristics in Quebec, 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Omar Abdul Kadir",authors:[{id:"11196",title:"Dr.",name:"Khiruddin",middleName:null,surname:"Abdullah",fullName:"Khiruddin Abdullah",slug:"khiruddin-abdullah"},{id:"151303",title:"Prof.",name:"Nik Norulaini",middleName:null,surname:"Ab Rahman",fullName:"Nik Norulaini Ab Rahman",slug:"nik-norulaini-ab-rahman"},{id:"151344",title:"Prof.",name:"Mohd Omar",middleName:null,surname:"Ab Kadir",fullName:"Mohd Omar Ab Kadir",slug:"mohd-omar-ab-kadir"},{id:"201647",title:"Mr.",name:"Mohd Talha",middleName:null,surname:"Anees",fullName:"Mohd Talha Anees",slug:"mohd-talha-anees"},{id:"203217",title:"Prof.",name:"Mohd Nawawi",middleName:null,surname:"Mohd Nordin",fullName:"Mohd Nawawi Mohd Nordin",slug:"mohd-nawawi-mohd-nordin"},{id:"203218",title:"Dr.",name:"Muhammad Izzuddin",middleName:null,surname:"Syakir Ishak",fullName:"Muhammad Izzuddin Syakir Ishak",slug:"muhammad-izzuddin-syakir-ishak"}]},{id:"55579",title:"Multicriteria Decision Analysis for Flood Risk Management: The Case of the Mapai Dam at the Limpopo River Basin, Mozambique",slug:"multicriteria-decision-analysis-for-flood-risk-management-the-case-of-the-mapai-dam-at-the-limpopo-r",signatures:"Avelino I. 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1. Introduction
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Ischemia-reperfusion (I/R) injury is a phenomenon in which cellular damage in a hypoxic organ is accentuated following the oxygen restoration [1, 2, 3], being a major pathophysiological event and cause of morbidity and mortality in liver resections and transplantation [4]. Despite the attempts to solve this problem, hepatic I/R is an unresolved problem. In addition, hepatic steatosis is a major risk factor for liver surgery, as it is associated with an increased complication index and postoperative mortality after major liver resection and transplantation, since steatotic livers show impaired regenerative response and reduced tolerance to I/R injury compared with non-steatotic ones. Of note, the prevalence of steatosis ranges from 24 to 45% of the population and consequently a further increase in the number of steatotic livers submitted to surgery is to be expected [5]. These observations highlight the need to develop protective strategies in liver surgical conditions.
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The mechanisms involved in liver I/R injury are complicated, mainly including microcirculation failure and oxidative stress [4]. A wide range of strategies has been attempted in order to mitigate I/R injury, mainly pharmacological treatments focused on gene therapy, improvement of preservation solutions, among others. However, an effective treatment is still lacking [4] since is difficult to achieve by targeting individual mechanism. Surgical strategies such as the ischemic preconditioning (IPC) technique noted for its effectiveness, as it activates several protective pathways against I/R injury in experimental models should be considered. IPC can be either applied directly to the target organ [6] or remotely (RIPC) to a distant vascular bed [7]. The benefits of the IPC and RIPC observed in experimental models of hepatic warm and cold ischemia [8, 9] prompted human trials of ischemic preconditioning. However, controversial results have been showed in the clinical practice. Therefore, the present chapter aims to describe the current knowledge of the IPC and RIPC in liver resections and liver transplantation of both steatotic and non-steatotic livers. In addition, the scientific controversies regarding the possible beneficial effects of these techniques, in experimental, translational and clinical studies in the setting of liver surgery will be discussed.
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2. Ischemic preconditioning
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Preconditioning the liver with ischemia involves a brief period of portal triad clamping usually between 5 and 15 min followed by a brief period of reperfusion (10–20 min) before a prolonged period of ischemia [10] (Figure 1). The exact mode of action of the IPC in the prevention of post-operative hepatic complication has not yet been fully comprehended. The molecular basis for IPC consists of a sequence of events in which in response to the triggers of IPC, a signal must be generated and transduced into an intracellular message leading to the effector mechanism of protection [11, 12]. As in the pathophysiology of hepatic I/R, in the modulation of hepatic injury induced by IPC, there is a complex interaction between different mechanisms and cell types [13].
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Figure 1.
Schematic illustration of ischemic preconditioning and remote ischemic preconditioning.
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2.1 IPC in experimental models
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Over the years, studies with experimental animal models have reported numerous positive effects of IPC on the alleviation of hepatic I/R injury and improvements of post-operative liver functioning. Various combinations of ischemia and reperfusion periods have been tested showing similar beneficial effects: lower aminotransferase levels, reduced hepatocellular injury, and higher survival rates [14]. IPC protected against mitochondrial ROS and thus reduce the oxidative stress-mediated damage in liver I/R injury [15, 16, 17, 18]. However, Rüdiger et al. showed that IPC is beneficial in liver submitted to an ischemic period of up to 75 min, but not for more prolonged ischemia [19].
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2.1.1 IPC in warm ischemia without liver resection
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IPC modulates several molecular pathways involving in I/R. When long periods of liver ischemia occur in hepatectomy or transplantation, the lack of oxygenation induces the rapid ATP consume to generate energy for cellular metabolism, resulting in adenosine production. The accumulation of adenosine provokes its transformation to hypoxanthine and xanthine leading to ROS production. IPC (5 min of ischemia/10 min reperfusion) modulates oxidative stress since reduces the accumulation of xanthine and the conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO). IPC (5 min of ischemia/10 min reperfusion) inhibits this ROS generating system, xanthine/XOD [11, 12, 13]. The activation of adenosine receptor A2 induced by IPC stimulates the activity of various intracellular kinases, like protein kinase C (PKC)-specifically PKC-δ- and p38 mitogen-activated protein kinase (p38MAPK) [20]. The activation of p38 and c-Jun N-terminal kinase (JNK-1) induced by IPC (10 min of ischemia/10 min reperfusion) is associated with increased cyclin D1 expression and entry into the cell cycle [21]. In addition to this, activation of p38 by different pharmacological strategies mimicking IPC effects, including agonists of the adenosine A2 receptor, carbon monoxide (CO), NO, and atrial natriuretic peptide (ANP) has been considered to be a crucial mechanism of hepatoprotection in the setting of liver surgery [22]. Moreover, autophagic flux is enhanced by liver IPC (10 min of ischemia/10 min reperfusion), since endothelial nitric oxide synthase (eNOS)-derived NO activates autophagy via phosphorylation of p38 MAPK [23]. On the other hand, the mechanism involved in the benefits of IPC might be different dependently of the type of the liver [1]. Indeed, in the presence of steatosis, IPC (5 min of ischemia/10 min reperfusion) reduces MAPK activation (JNK and p38), and this is associated with protection against hepatic I/R injury [24, 25]. The involvement of sirtuin-1 (SIRT1) induction in the benefits of IPC (5 min of ischemia/10 min reperfusion) on normothermic hepatic conditions has been reported [26]. Thus, SIRT1 inhibition decreased the expression of extracellular signal-regulated protein kinases (ERK) and augmented p38 protein levels [26]. ERK activation during IPC (5 min of ischemia/10 min reperfusion) protects against I/R injury in steatotic livers, by inhibiting apoptosis [27], whereas treatment with a p38 activator abolished the benefits of IPC on hepatic damage [24]. In addition, inactivation of GSK-3β by IPC (10 min of ischemia/10–15 min reperfusion) induces β-catenin signaling and subsequently up-regulates anti-apoptotic factors, such as Bcl-2 and survivin, leading to a significant amelioration of liver I/R injury [28, 29]. Figure 2 shows some of the protective mechanisms of IPC in the hepatic I/R injury.
The beneficial effects of IPC (10 min of ischemia/5 min reperfusion) in liver partial hepatectomy (PH) have been shown to be linked to better ATP recovery, NO production, antioxidant activities, and regulation of endoplasmic reticulum stress. All of this limited mitochondrial damage and apoptosis. In addition, the ERK1/2 and p38 MAPK activation induced by IPC in PH favors liver regeneration [30]. Furthermore, IPC (10 min of ischemia/10 min of reperfusion) can initiate hepatocyte proliferation action by a signaling mechanism involving TNF-α/IL-6 signal pathway [31]. In contrast, Qian et al. found that IPC impaired residual liver regeneration after major PH without portal blood bypass in rats. In this case, IPC was of 5 min ischemia/10 min reperfusion [32]. Another study testing regenerative capacity of the liver after IPC (10 min ischemia/10 min reperfusion) and PH showed that, despite IPC decreased hepatic injury, it did not influence the regeneration up to 48 h [33].
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2.1.3 IPC in reduced-size orthotopic liver transplantation
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In a reduced-size orthotopic liver transplantation (ROLT) rat model, IPC (10 min ischemia/10 min reperfusion) has been suggested that potentiates hepatocyte proliferation via TNF-α/IL-6-dependent pathway [34]. In addition, authors described that IPC inhibits IL-1 through NO, increases HGF, and reduces TGF-β to finally promote regeneration [34]. In addition, by another pathway independent of NO, IPC induced over-expression of heat shock protein 70 (HSP70) and heme-oxigenase-1 (HO-1) [35]. HO-1 protects against I/R injury, whereas the benefits resulting from HSP70 are mainly related to hepatocyte proliferation [35]. In addition, when steatotic grafts from living donors were transplanted applying IPC, the incidence of necrosis was reduced and the expression of both pro-autophagic beclin-1 and LC3 was increased [36]. On the other hand, in a rat model of ROLT with 70 or 90% hepatectomy, IPC (10 min ischemia/15 min reperfusion) impaired hepatic proliferative response by decreasing IL-6 and blunting cell cycle progression through a mechanism at least partially independent of STAT3 [37].
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2.1.4 IPC in orthotopic liver transplantation
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IPC (5 min ischemia/10 min reperfusion) has protected liver grafts in an experimental model of orthotopic liver transplantation (OLT) by modulation of xanthine/XOD system [38]. IPC reduced cAMP generation, thus ameliorating hepatic injury and survival of recipients with steatotic grafts [39]. In addition, AMPK activation by IPC (5 min ischemia/10 min reperfusion) increased the accumulation of adiponectin in steatotic liver grafts. This increased resistin and activated PI3K/Akt pathway, thus protecting steatotic livers against damage that follows transplantation [40]. However, it should be noted that in experimental liver transplantation from cadaveric donors, brain death abrogates the benefits of IPC (5 min ischemia/10 min reperfusion) in both steatotic and non-steatotic liver transplantation [41, 42]. Indeed, in the setting of liver transplantation, the inflammatory response induced by brain dead, present in the liver before the induction of IPC, would interact with various mechanistic aspects of IPC and block the eventual IPC response. Thus, Jimenez-Castro et al. have demonstrated that the treatment with acetylcholine protected liver grafts from the deleterious effects induced by brain death [41]. Under these conditions, the application of IPC was useful to improve the post-operative outcomes after transplantation.
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In addition to the liver, the benefits of IPC in experimental models of warm ischemia and liver transplantation have been observed in extrahepatic organs. Thus, IPC protects against lung damage associated with liver transplantation. The application of IPC in liver before I/R can prevent the release of both TNF and xanthine/XOD from the liver to the circulation. This regulated the P-selectin up-regulation and the neutrophil accumulation in remote organs such as lung and splanchnic organs [43].
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2.2 IPC in clinical trials
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The benefits of IPC observed in experimental models of hepatic resections and liver transplantation [8, 9] prompted human trials of IPC. The benefits of this surgical strategy have been evidenced in patients submitted to liver resections, protecting both steatotic and non-steatotic livers [44]. However, different results have been reported on the effects of IPC in the clinical practice of liver transplantation [45, 46].
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2.2.1 IPC in liver resections
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The first clinical trial testing IPC in patients undergoing major PH was reported by Clavien et al. [47]. Authors conclude that IPC (10 min ischemia/10 min reperfusion) is a protective strategy against hepatic ischemia in humans, particularly in young patients requiring a prolonged period of inflow occlusion and in the presence of steatosis [44, 47]. Other clinical trials also suggest that IPC (10 min ischemia/10 min reperfusion) provides both better intraoperative hemodynamic stability and anti-ischemic effects compared with intermittent clamping [48, 49]. Regarding the molecular basis of IPC (10 min ischemia/10 min reperfusion) in clinical PH, its beneficial effects have been shown to be linked to the down-regulation of potentially cytotoxic functions of PMNLs elicited by the Pringle Maneuver [50]. In addition, IPC (10 min ischemia/15 min reperfusion) increased the generation of adenosine and attenuated the degradation of purines in patients undergoing PH. Moreover, IPC appeared to attenuate apoptotic response of the liver remnant after resection [51]. Other clinical trial revealed that IPC (10 min ischemia/10 min reperfusion) stimulated the expression of the IL-1-RA, inducible nitric oxide synthase (iNOS), and Bcl-2 which decreased the inflammatory response and abrogated liver I/R injury [52]. Interestingly, since the ischemic period and pathophysiology are similar in partial hepatectomy and living donor liver transplantation, IPC could reduce damage and improve liver regeneration failure, a relevant risk factor in living donor liver transplantation [34]. Moreover, IPC could be implemented as an appropriate surgical strategy for the use of suboptimal livers, such as steatotic ones, in the clinical practice. Different results indicate that in patients with liver cirrhosis, IPC (5 min ischemia/5 min reperfusion) has been a suitable method to decrease liver I/R injury [53, 54]. Recently, the protective mechanism of IPC in patients with liver cirrhosis subjected to PH has been associated with changes in MAPK pathways [54]. In contrast, IPC applied for 15 min followed by 5 min reperfusion did not improve liver tolerance to I/R injury after PH in patients with liver cirrhosis [55]. In fact, RIPC did not induce changes in the postoperative levels of transaminases, bilirubin, and albumin nor reduced the morbidity and mortality rates and the duration of hospitalization [55].
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2.2.2 IPC in orthotopic liver transplantation
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Clinical trials in liver transplantation report different results on the effects of IPC against hepatic I/R injury. An IPC of 10 min ischemia/10 min reperfusion before liver transplantation reduced inflammatory response, improved ischemia tolerance, and decreased early graft function [56]. However, although the application of IPC (10 min ischemia/15 min reperfusion) reduced hepatocellular necrosis, it showed no clinical benefits [57]. In the largest prospective randomized trial of 10 min period IPC in liver transplantation from cadaveric donors, I/R injury was greater when IPC was applied [45], and it was called the “IPC paradox.” This was in accordance with the results obtained in experimental model of liver transplantation from cadaveric donors indicating that brain death abrogates the benefits of IP on post-operative outcomes [41, 42]. In fact, a microarray analysis in a randomized trial of 10 min IPC in deceased donor liver transplantation identified alteration of the expression of different antioxidant, immunological, lipid biosynthesis, cell development and growth transcripts, which are associated with hepatic damage [58].
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3. Remote ischemic preconditioning
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RIPC is a surgical technique by which preconditioning of one organ or vascular bed provides protection to distant organs or vascular beds during a sustained period of ischaemia (Figure 1). Few experimental and clinical studies, most of them from the last years, have addressed the effects of RIPC in livers submitted to I/R.
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3.1 RIPC in experimental models
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3.1.1 RIPC in warm ischemia without liver resection
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When RIPC is applied in the hind limb, it reduced hepatic warm I/R injury of mice, rats, and rabbits. RIPC (5–10 min ischemia/5–10 min reperfusion) has been shown to improve hepatic oxygenation and microcirculation and to reduce hepatic acidosis and damage [59, 60]. RIPC (4 min ischemia/4 min reperfusion) induced eNOS activation, leading to NO production to preserve sinusoidal structure and blood flow [61]. In addition, RIPC (5 min ischemia/5 min reperfusion) regulated the expressions of iNOS and eNOS and the expressions of miR-34a, miR-122, and miR-27b injury related miRs in fatty livers, thus attenuating I/R injury [62, 63]. RIPC (10 min ischemia/10 min reperfusion) also induced the up-regulation of HO-1, induced autophagy, and then reduced the damaged mitochondria to inhibit apoptosis and eventually protect hepatic cells from I/R injury [64, 65]. Moreover, RIPC (5 min ischemia/5 min reperfusion) reduced neutrophil activation and adhesion and TNF-α [66]. Controversial results have been described in a rat model in which RIPC protocol included 3 cycles of 10 min ischemia interspersed with 10 min of reperfusion periods [67]. Regarding the hemodynamic and microcirculatory alterations, RIPC protocol had beneficial effect; however, the histopathological findings were paradox [67, 68]. In addition to RIPC in the hind limb, when RIPC (5 min ischemia/5 min reperfusion) is applied in kidney, it has also been shown to protect liver against I/R injury, improving blood flow, histology, and redox-state [69]. Figure 2 shows some of the protective mechanisms of RIPC in the hepatic I/R injury.
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3.1.2 RIPC in liver resections
\n
A recent study in mice showed that RIPC (3 cycles of 5 min of ischemia each followed by 5 min of reperfusion) applied in the right femoral vascular bundle did not affect regeneration after 70%-PH [70]. However, of clinical interest, the same protocol of RIPC improved liver weight gain and hepatocyte mitoses after 90%-PH [70].
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3.1.3 RIPC in orthotopic liver transplantation
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In an experimental model of OLT, RIPC based on 4 cycles of 5 min of ischemia and 5 min of reperfusion was applied on the infrarenal aorta. The results suggested that RIPC might confer potent protection against the detrimental effects of I/R injury including apoptosis and inflammation [71]. In addition, authors suggest that HO-1 overexpression could play an orchestrating role in RIPC (5 min ischemia/5 min reperfusion)-mediated organ protection [71]. In addition, a recent study showed that the same protocol of RIPC also exhibits protective effects, as indicated by increased portal venous flow and microcirculation, as well as decreased AST and ALT levels and a reduced Suzuki score in a model of OLT [72]. Authors suggest that the RIPC inhibited the macrophage migration inhibitory factor (MIF), which resulted in the modulation of further downstream pro-survival mechanisms (iNOS, RISK-, SAFE-pathways), protecting graft injury [72].
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3.2 RIPC in clinical trials
\n
Only three studies dated in 2017 and 2018 have addressed the effects of RIPC in the clinical liver surgery.
\n
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3.2.1 RIPC in liver resections
\n
In major HP, RIPC was shown to reduce liver I/R injury as indicated by a reduction in post-operative transaminases and increased ICG clearance [73]. To induce RIPC, a tourniquet was inflated to induce 10 min of ischemia and then deflated for 10 min to reperfuse the leg. This was repeated twice prior to commencing the operation. RIPC has potential to reduce liver injury following PH [73]. In addition, other clinical trial where RIPC was induced by three cycles of 5 min of ischemia of right upper limb followed by 5 min of reperfusion showed hepatic cytoprotective effects assessed by cholinesterase and bilirubin levels during liver resection [74]. Authors suggest that a shorter protocol of RIPC is safe and of equal effect, although the mechanisms of this effect must be investigated in future studies [74].
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3.2.2 RIPC in orthotopic liver transplantation
\n
The first trial to investigate the feasibility of RIPC in liver transplant recipients was addressing by Robertson et al. [75]. The trial involved randomization of adult recipients undergoing deceased donor liver transplantation. To induce RIPC, a tourniquet was inflated for 5 min and then deflated for 5 min to reperfuse the leg. This was repeated twice and completed prior to the transplant procedure. Authors demonstrated that RIPC is feasible, acceptable to patients and safe in this group of patients but clinical benefits within the first 3 months post transplantation were not detected [75]. Authors suggest that 5 min cycles are insufficient to create localized ischemia in the limb [75].
\n
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4. Conclusion
\n
Surgical strategies such as the induction of IPC or RIPC could be of clinical interest in human liver resections and liver transplantation in both steatotic and non-steatotic livers. Both IPC and RIPC are easy to apply, inexpensive and does not require the use of drugs with potential side effects, but it requires a period of pre-ischemic manipulation for organ protection. These preconditioning techniques have been demonstrated to be promising tools for the reduction of hepatic I/R injury in different warm and cold ischemia models. Therefore, the potential applications of IPC and RIPC in human liver surgery are numerous. The benefits of IPC and RIPC have been evidenced in patients submitted to partial hepatectomy in both steatotic and non-steatotic livers. In our view, IPC and RIPC could resolve, at least partially, the lack of liver grafts available for transplant, since it can improve the post-operative outcome of liver grafts from extended criteria donors. However, controversial results on the effects of IPC and RIPC have been reported in the clinical practice of liver transplantation. It should be considered that the underlying mechanisms of both IPC and RIPC and their relevance in liver surgery remain poorly understood. Indeed, as stated along this chapter, most of the experimental studies have been focused on the molecular changes occurring during IPC and RIPC in non-brain-dead donors. Moreover, most of the experimental studies of IPC and RIPC have been performed only in I/R injury models, without hepatic resections or liver transplantation. The tolerance to I/R injury induced by either IPC or RIPC is dependently of the number of cycles of I/R and their duration as well as the surgical procedures. The clinical application of strategies designed at benchside will depend on the use of experimental models of IPC and RIPC that resemble as much as possible the clinical conditions. Multidisciplinary research groups should devote additional efforts to better understand the molecular mechanisms of IPC and RIPC during the different clinical liver surgery setting to ultimately develop useful surgical strategies aimed at reducing I/R damage.
\n
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Acknowledgments
\n
This research was supported by the Ministerio de Economía y Competitividad (project grant SAF-2015-64857-R) Madrid, Spain; the European Union (FondosFeder, “una manera de hacer Europa”); by CERCA Program/Generalitat de Catalunya; by the Secretaria d’Universitats i Recerca (Grant 2017SGR-551) Barcelona, Spain. J Gracia-Sancho received continuous funding from the Instituto de Salud Carlos III (currently FIS PI17/00012) and the CIBEREHD, from Ministerio de Ciencia, Innovación y Universidades.
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Conflict of interest
The authors declare that they have no conflict of interest.
\n',keywords:"ischemia-reperfusion injury, liver resections, liver transplantation, ischemic preconditioning, remote ischemic preconditioning",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/66928.pdf",chapterXML:"https://mts.intechopen.com/source/xml/66928.xml",downloadPdfUrl:"/chapter/pdf-download/66928",previewPdfUrl:"/chapter/pdf-preview/66928",totalDownloads:847,totalViews:0,totalCrossrefCites:1,dateSubmitted:"January 25th 2019",dateReviewed:"April 1st 2019",datePrePublished:"May 3rd 2019",datePublished:"November 27th 2019",dateFinished:"April 26th 2019",readingETA:"0",abstract:"Ischemia-reperfusion (I/R) injury is an important cause of liver damage occurring during surgical procedures. In liver resection, I/R causes post-operative transaminasemia and liver function failure. In liver transplantation, I/R causes graft dysfunction, ranging from biochemical abnormalities to primary non-function of the transplanted organ. Ischemic preconditioning is a surgical strategy to reduce the severity of I/R and improve post-operative outcomes by prior exposure to a brief period of vascular occlusion directly to the target organ or remotely to a distant vascular bed. This chapter aims to discuss the different ischemic preconditioning strategies in both liver resection surgery and liver transplantation. In addition, we will describe the differences of such surgical strategies in both steatotic and non-steatotic livers in both preclinical experiments and clinical practice. Such information may be useful to guide the design of the effective ischemic preconditioning methods in the surgery of hepatic resections and liver transplantation.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66928",risUrl:"/chapter/ris/66928",signatures:"Maria Eugenia Cornide-Petronio, Mónica B. Jiménez-Castro, Jordi Gracia-Sancho and Carmen Peralta",book:{id:"7875",type:"book",title:"Liver Disease and Surgery",subtitle:null,fullTitle:"Liver Disease and Surgery",slug:"liver-disease-and-surgery",publishedDate:"November 27th 2019",bookSignature:"Georgios Tsoulfas and Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/7875.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-066-6",printIsbn:"978-1-78985-065-9",pdfIsbn:"978-1-83880-273-8",isAvailableForWebshopOrdering:!0,editors:[{id:"57412",title:"Prof.",name:"Georgios",middleName:null,surname:"Tsoulfas",slug:"georgios-tsoulfas",fullName:"Georgios Tsoulfas"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"74565",title:"Dr.",name:"Carmen",middleName:null,surname:"Peralta",fullName:"Carmen Peralta",slug:"carmen-peralta",email:"cperalta@clinic.ub.es",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer",institutionURL:null,country:{name:"Spain"}}},{id:"150568",title:"Dr.",name:"Mónica B.",middleName:null,surname:"Jiménez-Castro",fullName:"Mónica B. Jiménez-Castro",slug:"monica-b.-jimenez-castro",email:"monicabjimenez@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"245729",title:"Dr.",name:"Maria Eugenia",middleName:null,surname:"Cornide Petronio",fullName:"Maria Eugenia Cornide Petronio",slug:"maria-eugenia-cornide-petronio",email:"cornide@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"267094",title:"Dr.",name:"Jordi",middleName:null,surname:"Gracia-Sancho",fullName:"Jordi Gracia-Sancho",slug:"jordi-gracia-sancho",email:"jordi.gracia@idibaps.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Ischemic preconditioning",level:"1"},{id:"sec_2_2",title:"2.1 IPC in experimental models",level:"2"},{id:"sec_2_3",title:"2.1.1 IPC in warm ischemia without liver resection",level:"3"},{id:"sec_3_3",title:"2.1.2 IPC in liver resections under warm ischemia",level:"3"},{id:"sec_4_3",title:"2.1.3 IPC in reduced-size orthotopic liver transplantation",level:"3"},{id:"sec_5_3",title:"2.1.4 IPC in orthotopic liver transplantation",level:"3"},{id:"sec_7_2",title:"2.2 IPC in clinical trials",level:"2"},{id:"sec_7_3",title:"2.2.1 IPC in liver resections",level:"3"},{id:"sec_8_3",title:"2.2.2 IPC in orthotopic liver transplantation",level:"3"},{id:"sec_11",title:"3. Remote ischemic preconditioning",level:"1"},{id:"sec_11_2",title:"3.1 RIPC in experimental models",level:"2"},{id:"sec_11_3",title:"3.1.1 RIPC in warm ischemia without liver resection",level:"3"},{id:"sec_12_3",title:"3.1.2 RIPC in liver resections",level:"3"},{id:"sec_13_3",title:"3.1.3 RIPC in orthotopic liver transplantation",level:"3"},{id:"sec_15_2",title:"3.2 RIPC in clinical trials",level:"2"},{id:"sec_15_3",title:"3.2.1 RIPC in liver resections",level:"3"},{id:"sec_16_3",title:"3.2.2 RIPC in orthotopic liver transplantation",level:"3"},{id:"sec_19",title:"4. Conclusion",level:"1"},{id:"sec_20",title:"Acknowledgments",level:"1"},{id:"sec_23",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Serafin A, Rosello-Catafau J, Prats N, Xaus C, Gelpi E, Peralta C. Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. The American Journal of Pathology. 2002;161:587-601. 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Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Annals of Surgery. 2000;232:155-162. DOI: 10.1097/00000658-200008000-00001\n'},{id:"B48",body:'Nuzzo G, Giuliante F, Vellone M, De Cosmo G, Ardito F, Murazio M, et al. Pedicle clamping with ischemic preconditioning in liver resection. Liver Transplantation. 2004;10:S53-S57. DOI: 10.1002/lt.20045\n'},{id:"B49",body:'Choukèr A, Schachtner T, Schauer R, Dugas M, Löhe F, Martignoni A, et al. Effects of Pringle manoeuvre and ischaemic preconditioning on haemodynamic stability in patients undergoing elective hepatectomy: a randomized trial. British Journal of Anaesthesia. 2004;93:204-211. DOI: 10.1093/bja/aeh195\n'},{id:"B50",body:'Choukèr A, Martignoni A, Schauer R, Dugas M, Rau HG, Jauch KW, et al. Beneficial effects of ischemic preconditioning in patients undergoing hepatectomy: the role of neutrophils. Archives of Surgery. 2005;140:129-136. DOI: 10.1001/archsurg.140.2.129\n'},{id:"B51",body:'Arkadopoulos N, Kostopanagiotou G, Theodoraki K, Farantos C, Theodosopoulos T, Stafyla V, et al. Ischemic preconditioning confers antiapoptotic protection during major hepatectomies performed under combined inflow and outflow exclusion of the liver. A randomized clinical trial. World Journal of Surgery. 2009;33:1909-1915. DOI: 10.1007/s00268-009-0117-0\n'},{id:"B52",body:'Barrier A, Olaya N, Chiappini F, Roser F, Scatton O, Artus C, et al. Ischemic preconditioning modulates the expression of several genes, leading to the overproduction of IL-1Ra, iNOS, and Bcl-2 in a human model of liver ischemia-reperfusion. The FASEB Journal. 2005;19:1617-1626. DOI: 10.1096/fj.04-3445com\n'},{id:"B53",body:'Li SQ , Liang LJ, Huang JF, Li Z. Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis. World Journal of Gastroenterology. 2004;10:2580-2584. DOI: 10.3748/wjg.v10.i17.2580\n'},{id:"B54",body:'Wang L, Feng L, Rong W, Liu M, Wu F, Yu W, et al. Regional ischemic preconditioning has clinical value in cirrhotic HCC through MAPK pathways. Journal of Gastrointestinal Surgery. 2018. DOI: 10.1007/s11605-018-3960-1\n'},{id:"B55",body:'Ye B, Zhao H, Hou H, Wang G, Liu F, Zhao Y, et al. Ischemic preconditioning provides no additive clinical value in liver resection of cirrhotic and non-cirrhotic patients under portal triad clamping: A prospective randomized controlled trial. Clinics and Research in Hepatology and Gastroenterology. 2014;38:467-474. DOI: 10.1016/j.clinre.2014.03.013\n'},{id:"B56",body:'Azoulay D, Del Gaudio M, Andreani P, Ichai P, Sebag M, Adam R, et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft’s preservation and function: the ying and the yang. Annals of Surgery. 2005;242:133-139. 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Remote ischemic preconditioning protects liver ischemia-reperfusion injury by regulating eNOS-NO pathway and liver microRNA expressions in fatty liver rats. Hepatobiliary & Pancreatic Diseases International. 2017;16:387-394. DOI: 10.1016/S1499-3872(17)60006-7\n'},{id:"B64",body:'Lai IR, Chang KJ, Chen CF, Tsai HW. Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1. Transplantation. 2006;81:1311-1137. DOI: 10.1097/01.tp.0000203555.14546.63\n'},{id:"B65",body:'Wang Y, Shen J, Xiong X, Xu Y, Zhang H, Huang C, et al. Remote ischemic preconditioning protects against liver ischemia-reperfusion injury via heme oxygenase-1-induced autophagy. PLoS One. 2014;9:e98834. DOI: 10.1371/journal.pone.0098834\n'},{id:"B66",body:'Tapuria N, Junnarkar S, Abu-Amara M, Fuller B, Seifalian AM, Davidson BR. Modulation of microcirculatory changes in the late phase of hepatic ischaemia-reperfusion injury by remote ischaemic preconditioning. HPB: The Official Journal of the International Hepato Pancreato Biliary Association. 2012;14:87-97. DOI: 10.1111/j.1477-2574.2011.00407.x\n'},{id:"B67",body:'Magyar Z, Varga G, Mester A, Ghanem S, Somogyi V, Tanczos B, et al. Is the early or delayed remote ischemic preconditioning the more effective from a microcirculatory and histological point of view in a rat model of partial liver ischemia-reperfusion? Acta Cirúrgica Brasileira. 2018;33:597-608. DOI: 10.1590/s0102-865020180070000005\n'},{id:"B68",body:'Magyar Z, Mester A, Nadubinszky G, Varga G, Ghanem S, Somogyi V, et al. Beneficial effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in the rat. Clinical Hemorheology and Microcirculation. 2018;70:181-190. DOI: 10.3233/CH-170351\n'},{id:"B69",body:'Czigány Z, Turóczi Z, Ónody P, Harsányi L, Lotz G, Hegedüs V, et al. Remote ischemic perconditioning protects the liver from ischemia-reperfusion injury. 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DOI: 10.1097/SHK.0000000000001307\n'},{id:"B73",body:'Kanoria S, Robertson FP, Mehta NN, Fusai G, Sharma D, Davidson BR. Effect of remote ischaemic preconditioning on liver injury in patients undergoing major hepatectomy for colorectal liver metastasis: a pilot randomised controlled feasibility trial. World Journal of Surgery. 2017;41:1322-1330. DOI: 10.1007/s00268-016-3823-4\n'},{id:"B74",body:'Rakić M, Patrlj L, Amić F, Aralica G, Grgurević I. Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections. International Journal of Surgery. 2018;54:248-253. DOI: 10.1016/j.ijsu.2018.05.001\n'},{id:"B75",body:'Robertson FP, Goswami R, Wright GP, Imber C, Sharma D, Malago M, et al. Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB: The Official Journal of the International Hepato Pancreato Biliary Association. 2017;19:757-767. DOI: 10.1016/j.hpb.2017.05.005\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Maria Eugenia Cornide-Petronio",address:null,affiliation:'
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
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Barcelona Hepatic Hemodynamic Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Centro de Investigaciones Biomédicas en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain
Facultad de Medicina, Universidad International de Cataluña, Spain
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Open Access publishing helps remove barriers and allows everyone to access valuable information, but article and book processing charges also exclude talented authors and editors who can’t afford to pay. The goal of our Women in Science program is to charge zero APCs, so none of our authors or editors have to pay for publication.
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Cultivation of traditional crops in different regions of the world, aside maintaining biodiversity in agriculture, also avails humanity of regulatory services such as nutrient cycling, carbon sequestration, control of soil erosion, reduction of greenhouse gas emission and control of hydrological processes. However, man through over-exploitation of some plant species with utter neglect to some other either deliberately or otherwise through modern agricultural systems that promote cultivation of a few high-input and high-yielding crop species caused disaffection to biodiversity with consequences of reduction in its regulatory services. In this chapter, different landraces of crops are examined, their usefulness in the maintenance of genetic diversity is explored, and implications of their depletion are discussed.",book:{id:"6317",slug:"rediscovery-of-landraces-as-a-resource-for-the-future",title:"Rediscovery of Landraces as a Resource for the Future",fullTitle:"Rediscovery of Landraces as a Resource for the Future"},signatures:"Musibau A. Azeez, Amos O. Adubi and Felicia A. Durodola",authors:[{id:"228835",title:"Dr.",name:"Musibau",middleName:null,surname:"Azeez",slug:"musibau-azeez",fullName:"Musibau Azeez"},{id:"240210",title:"MSc.",name:"Felicia",middleName:null,surname:"Durodola",slug:"felicia-durodola",fullName:"Felicia Durodola"},{id:"240213",title:"MSc.",name:"Amos",middleName:null,surname:"Adubi",slug:"amos-adubi",fullName:"Amos Adubi"}]}],mostDownloadedChaptersLast30Days:[{id:"40178",title:"Molecular Markers and Marker-Assisted Breeding in Plants",slug:"molecular-markers-and-marker-assisted-breeding-in-plants",totalDownloads:22919,totalCrossrefCites:75,totalDimensionsCites:140,abstract:null,book:{id:"3060",slug:"plant-breeding-from-laboratories-to-fields",title:"Plant Breeding from Laboratories to Fields",fullTitle:"Plant Breeding from Laboratories to Fields"},signatures:"Guo-Liang Jiang",authors:[{id:"158810",title:"Dr.",name:"Guo-Liang",middleName:null,surname:"Jiang",slug:"guo-liang-jiang",fullName:"Guo-Liang Jiang"}]},{id:"60074",title:"Pollen Germination in vitro",slug:"pollen-germination-in-vitro",totalDownloads:2714,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Pollen germination in vitro is a reliable method to test the pollen viability. It also addresses many basic questions in sexual reproduction and particularly useful in wide hybridization. Many pollen germination medium ranging from simple sugars to complex one having vitamins, growth regulators, etc. in addition to various minerals have been standardized to germinate pollen artificially. The different media, successful pollen germination methods, procedures from pollen germination studies with wheat, rye, brinjal, pigeonpea and its wild relatives are discussed.",book:{id:"6659",slug:"pollination-in-plants",title:"Pollination in Plants",fullTitle:"Pollination in Plants"},signatures:"Jayaprakash P",authors:[{id:"235465",title:"Dr.",name:"Jayaprakash",middleName:null,surname:"P",slug:"jayaprakash-p",fullName:"Jayaprakash P"}]},{id:"62376",title:"Genotype × Environment Interaction: A Prerequisite for Tomato Variety Development",slug:"genotype-environment-interaction-a-prerequisite-for-tomato-variety-development",totalDownloads:2262,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"Tomato (Solanum lycopersicum L.) is the second most important vegetable crop in the world due to its high level of nutrition particularly in vitamins and antioxidants. It is grown in several ecologies of the world due to its adaptability and ease of cultivation. Besides field conditions, tomatoes are grown in controlled environments which range from hydroponics and simple high tunnel structures to highly automated screen houses in advanced countries. However, the yield and quality of the fruits are highly influenced by the environment. This results in unpredictable performances in different growing environments in terms of quality, a phenomenon known as genotype by environment (G × E) interaction which confounds selection efficiency. Various approaches are employed by plant breeders to evaluate and address the challenges posed by genotype by environment interaction. This chapter discusses various field and controlled environments for growing tomatoes and the effect of these environments on the performance of the crop. The various types of genotype × environment interactions and their effect of the tomato plant are discussed. Finally, efforts are made to suggest ways and methods of mitigating the confounding effects of genotype × environment interaction including statistical approaches.",book:{id:"6422",slug:"recent-advances-in-tomato-breeding-and-production",title:"Recent Advances in Tomato Breeding and Production",fullTitle:"Recent Advances in Tomato Breeding and Production"},signatures:"Michael Kwabena Osei, Benjamin Annor, Joseph Adjebeng-\nDanquah, Agyemang Danquah, Eric Danquah, Essie Blay and Hans\nAdu-Dapaah",authors:[{id:"204223",title:"Dr.",name:"Agyemang",middleName:null,surname:"Danquah",slug:"agyemang-danquah",fullName:"Agyemang Danquah"},{id:"217531",title:"M.Sc.",name:"Michael Kwabena",middleName:null,surname:"Osei",slug:"michael-kwabena-osei",fullName:"Michael Kwabena Osei"},{id:"217760",title:"Dr.",name:"Joseph",middleName:null,surname:"Adjebeng-Danquah",slug:"joseph-adjebeng-danquah",fullName:"Joseph Adjebeng-Danquah"},{id:"217768",title:"MSc.",name:"Benjamin",middleName:null,surname:"Annor",slug:"benjamin-annor",fullName:"Benjamin Annor"},{id:"247378",title:"Dr.",name:"Eric Y.",middleName:null,surname:"Danquah",slug:"eric-y.-danquah",fullName:"Eric Y. Danquah"},{id:"248095",title:"Prof.",name:"Essie",middleName:null,surname:"Blay",slug:"essie-blay",fullName:"Essie Blay"},{id:"248096",title:"Prof.",name:"Hans",middleName:null,surname:"Adu-Dapaah",slug:"hans-adu-dapaah",fullName:"Hans Adu-Dapaah"}]},{id:"45153",title:"Irrigation of Sandy Soils, Basics and Scheduling",slug:"irrigation-of-sandy-soils-basics-and-scheduling",totalDownloads:5584,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"3357",slug:"crop-production",title:"Crop Production",fullTitle:"Crop Production"},signatures:"Mohamed S. Alhammadi and Ali M. Al-Shrouf",authors:[{id:"78245",title:"Dr.",name:"Mohamed",middleName:"Salman",surname:"Alhammadi",slug:"mohamed-alhammadi",fullName:"Mohamed Alhammadi"},{id:"159904",title:"Mr.",name:"Ali",middleName:null,surname:"Al-Shrouf",slug:"ali-al-shrouf",fullName:"Ali Al-Shrouf"}]},{id:"58553",title:"Water Stress: Morphological and Anatomical Changes in Soybean (Glycine max L.) Plants",slug:"water-stress-morphological-and-anatomical-changes-in-soybean-glycine-max-l-plants",totalDownloads:1793,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"Water stress is one of the most important physiological stress factors that adversely affect soybeans in many critical aspects of their growth and metabolism. Soybean’s growth, development and productivity are severely diminished, when soil or cell water potential becomes inadequate to sustain metabolic functioning. However, little has been done to gather comprehensive information regarding the specific changes that occur in water-stressed plants at the anatomical and morphological level. In this study, deviations in root growth, shoot growth, stomatal conductance, yield components and anatomical features are reported. Treatments with two levels of water stress imposed by reducing irrigation (once in 7 days or once in 15 days) revealed that, all cultivars (Dundee, LS 677, LS 678, TGx 1740-2F, TGx 1835-10E and Peking) were highly susceptible to prolonged water stress, exhibiting severe dehydration and death. A 15.0 and 30.0% survival frequency was obtained in plants irrigated once in 7 days; LS 677 and Peking, respectively. Unlike many other stresses, water deficit did not only affect the density of stomata, but, photosynthesis was affected by the lower levels of tissue CO2. These results suggest that, balanced biochemical, physiological, anatomical and morphological regulations are necessary for increased growth and yields in soybean.",book:{id:"6377",slug:"plant-abiotic-stress-and-responses-to-climate-change",title:"Plant, Abiotic Stress and Responses to Climate Change",fullTitle:"Plant, Abiotic Stress and Responses to Climate Change"},signatures:"Phetole Mangena",authors:[{id:"191391",title:"Mr.",name:"Phetole",middleName:null,surname:"Mangena",slug:"phetole-mangena",fullName:"Phetole Mangena"}]}],onlineFirstChaptersFilter:{topicId:"311",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. 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