\r\n\tThe proposed subtitles are \r\n\t• Municipal Solid waste landfills \r\n\t• Industrial waste landfills \r\n\t• Hazardous waste landfills \r\n\t• Global approaches and technologies \r\n\t• Legal and economic aspects
",isbn:"978-1-83768-352-9",printIsbn:"978-1-83768-351-2",pdfIsbn:"978-1-83768-353-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"94513c9322631c6de257373b093d7d3a",bookSignature:"Dr. Suriyanarayanan Sarvajayakesavalu",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12042.jpg",keywords:"Landfills, Generation, Recycling, Disposal, Liquid, Gaseous, Radioactive, Methods, Techniques, Practices, Solid Waste Generation",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 8th 2022",dateEndSecondStepPublish:"July 6th 2022",dateEndThirdStepPublish:"September 4th 2022",dateEndFourthStepPublish:"November 23rd 2022",dateEndFifthStepPublish:"January 22nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"5 hours",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Active researcher and academician specialized in Environmental Monitoring.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"237021",title:"Dr.",name:"Suriyanarayanan",middleName:null,surname:"Sarvajayakesavalu",slug:"suriyanarayanan-sarvajayakesavalu",fullName:"Suriyanarayanan Sarvajayakesavalu",profilePictureURL:"https://mts.intechopen.com/storage/users/237021/images/system/237021.png",biography:"Prof. Dr. Suriyanarayanan Sarvajayakesavalu, MSc, MPhil, Ph.D., is Deputy Director Research of Vinayaka Mission's Research Foundation (VMRF) - Deemed to be University. 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1. Introduction
Assistance systems in Ambient Assisted Living and in medical care have to recognize relevant situations, that require fast assistive intervention. Former projects in this field like tecla [1, 2, 3] or PAUL [4] have been focused on the application of the new AAL-technologies in AAL test beds to get information about the acceptance level [5, 6] of the technologies and the different new applications for the patients. Additionally, business models [7, 8] have been drafted to realize a successful AAL business area in future.
The clinical established measurement technology for diagnostic, monitoring and risk stratification does not translate directly to the outpatient area (ambulant or domestically environment). The key challenge is, that many relevant situations are only noticeable, when various sensor modalities are merged – such as for discrimination between pathological, emotional [9] or stress induced increase of the heart rate [10]. This is only possible by the use of the combination of multiple different sensors [11]. The same applies to the analysis of joint kinematics of everyday activities, which requires more and inertial sensors with higher accuracy.
The next generation of radio networks (5G) [12] shows the possibility of introducing new possibilities of real-time communication in all areas of life with very low latency and high data rates. One speaks of a so-called tactile Internet. People come into contact with their surroundings through their senses, which involve several different reaction times. Here, muscular, audio-visual and tactile response times are of particular importance. The typical muscular response time is around 1 second, that of the hearing at 100 ms, while the visual response time is in the range of 10 ms [13].
In the case of active control of an object, such as a car or a machine, the information must first be recorded while a reaction must be carried out at the same time. The well-known use of a touch screen requires that you move your finger in a controlled manner across the screen. It is therefore necessary that the touch screen can achieve a response time of less than 1 ms in order not to produce any noticeable delay in the visual impression. In the case of an active prothesis, which was applied in this study, the response time must be below 10 ms to achieve a practical application basis for its use in daily life. Therefore, fast sensor data-frameworks are needed to analyze the conditions of real-time identification and subsequently provide a medical valid corresponding assistance [12, 14].
The aim of the fast care project was to develop a real-time sensor data analysis framework [9] for intelligent assistance systems in the area of Ambient Assisted Living (AAL), eHealth, mHealth, tele-rehabilitation and tele-care. It provides a medically valid, integrated real-time situation picture based on a distributed, ad hoc networking, everyday use and energy-efficient sensor infrastructure with a latency of less than several ms. The integrated situation picture that includes physiological, cognitive, kinematic information of the patient is generated by the intelligent fusion of sensor data [15, 16]. It can serve as a basis both for the rapid detection of risks and dangerous situations as well as for everyday use medical assistance systems that autonomously intervene in real time [17, 18] and allows active telemedical feedback [10].
In this chapter of the book, after an introduction, the technical goals and implementation options of a fast sensor network with real-time data analysis are presented followed without contact by the structure of the overall system. In the Section 2, the details of the technological concept such as data fusion and telemetry are presented. All relevant interfaces for real-time applications are discussed in detail. In the following section, the hardware, sensors/actuators and the specific installation of the demonstrator in laboratory operation are discussed. In the following part, details of the individual sensor systems and the corresponding visualization of the sensor data presented by an Avatar are distinguished. In the Section 3, the acceptance test for the use of the sensor components of the demonstration are analyzed and discussed. Finally, a summary with a view of upcoming developments will be given at the end.
2. Technical goals and solutions
2.1 System setup
The basis of a medical valid - integrated real-time picture of the situation is an ad hoc interconnected sensor infrastructure. Its latency period should be very fast to fulfill the boundaries of a haptive working network. Here, physiological, cognitive and kinematic information of a patient are captured with the help of intelligent sensor data fusion. These data can be combined to provide an integrated picture of the patient’s physical and mental situation. In this way, it should be ensured that the framework can be used for applications, in which feedback has to be embedded synchronically. This can be realized in visual, auditive, tactile or proprioceptive string of perception, such as in the field of support of motor function and kinematics for the rehabilitation and for active prosthetics and orthotics.
Figure 1 shows an overview of the system concept of the project approach for an integrated sensor infrastructure in the home of an elderly person. It consists of GPS data, air pressure and temperature data, vital parameters, cameras, optical sensors and so-called inertial sensors (IMU) together.
Figure 1.
Integrated system concept.
These sensor data are summarized in real-time and buffered in a database system. From this database, an integrated real-time situation analysis is generated that touches on three areas of human life: firstly, the kinematic data such as localization, movement and posture. The second area is the cognitive sub-area with awareness, emotionality and mental clarity. The third subsection deals with the physiological data in which cardiovascular metabolic and neurological data can be recorded and analyzed.
This entirety of the data in the home of the living person can be evaluated integratively and can accordingly provide a precise analysis of his health. In this project, apart from the emotional and neurological aspects, all the addressed areas were recorded and evaluated. After evaluating the situation analysis, actuators are implemented for rehabilitation, in a special case of an active prosthesis of the foot, which can adjust different heel heights, automatic adaptation to different floor conditions or rapid walking. Furthermore, the client should be provided with a real-time display of his vital parameters as a so-called Smart Home Assistant, which can give a helpful health support to the client.
For a real-time application, it is necessary that the latency times between sensor detection and actuator actuation are less than several Milliseconds. This ensures a so-called haptic functionality of the system and can be achieved with the help of new radio technologies and fast network technologies such as FTTH and the fifth generation of mobile radio networks (5G). To ensure private data security, all data is stored and evaluated in a so-called home server which is situated in the client’s apartment. Further intervention options are possible by a secure cloud connection to medical services or the system administrators for possible updates of the sensor and actuator components.
The challenge of a distributed, real-time medical sensor technology and signal processing is to be processed by means of sensor-based data processing and sensor hubs, optical sensors, hardware system optimization, the development of distributed systems as well as by interface network sensors. The focus of the project was on the intelligent fusion of sensor and actuator data as well as the evaluation and delivery in real-time. In order to meet this objective, the following developments took place in the Ambient Assisted Living (AAL)-Lab of the Harz University of Applied Sciences in Wernigerode (Figure 2).
Analysis of requirements
Data acquisition
Data analysis
Data fusion
Acceptance analysis
Situation detection and assistance in real-time
Figure 2.
Application of fast care real-time sensor system.
The objective of a distributed, real-time medical sensor technology and signal processing is to get an evaluation of the patient’s situation from the available data in real-time. The main application focuses in the area of the application of orthopedic devices. For example, the optimization process of the leg prosthesis` damping members and active foot positioning points shall be executed online. Currently, these parameters are performed offline and hand-made by orthopedic technicians with variable quality. This often leads to suboptimal adapted orthopedic devices; whose functionality and efficacy are correspondingly limited and therefore to an unsatisfactory rehabilitation outcome. This system approach of the sensor integration into an active foot prothesis is called a real-time active prosthetics/orthotics -time controller. Another project section describes the online execution of the estimation of cognitive condition, the motion analysis for rehabilitation and cardiopulmonary performance.
2.2 Technological concept
Based on the project goals, the technical and content requirements of the technological topics to be worked on were specified, categorized and summarized by the individual partners. The basic requirements are listed in the following areas:
Hardware/sensors,
Network,
Data analysis,
Actuators/intervention/feedback
The system diagram of the research approach of the fast care framework is shown in the Figure 3. The fast care framework is the technical basis for the realization of the fast care project, which implements the fusion of heterogeneous sensors via heterogeneous networks. The basic idea of the fast care framework is to derive a condition from the past and the current states of the sensory data using different newly developed sensor applications, including the following areas and interfaces (see Figure 3). From the network topological representation, a breakdown of the used network interfaces was made, specified by the project partners. Based on this, a suitable communication protocol was selected regarding the individual implementations. Communication via MQTT forms the basis of the used communication between the sensor-applications and the real-time controller depicted in Figure 3. In the left side of the figure, the sensor-applications are situated, consisting of a Kinect system for motion data, inertial motion units (IMU) for the detection of movements of body and objects in a fixed sequence for the analysis of a workout in a kitchen, motion sensors/actuators in an active intelligent prothesis, a camera based heart rate and breathe sensor, and finally a special sensor of volatile organic components in the room air. Prothesis, body and objects sensors are connected via smartphone and Bluetooth low energy. While the smartphone transfers the data to the real-time controller.
Figure 3.
Network topology.
In total, the seven sensor components are listed there on the left. The active prosthesis, the heart rate measurement, the respiratory rate measurement, the detection of VOC components in the breathing air, the detection of movement in the room and the measurement of room temperature and humidity, as well as the use of the emergency button, uses the corresponding network structure according to the blocks shown in the sketch.
After the individual implementations of the interfaces a suitable software communication server was selected. The MQTT protocol [19] was implemented using a real-time capable Linux variant. Suitable hardware was procured by the project partner of the Harz University of Applied Sciences, a suitable operating system was installed and the MQTT software server “mosquitto” [20] was installed and configured. The definition of topics (message channels) and the specification of the data formats were necessary for smooth communication of the individual partner realizations “in-itself” and “with each other.” A detailed description of the communication formats between the sensors built by the partners and the MQTT server can be found in the final design plan of the fast care project [21].
At the beginning of the project, the communication protocols that should be used between the individual project partners for data exchange have been discussed and clearly defined (see Table 1). The interfaces for the network used in the project are essentially the Bluetooth LE transmission, the Wi-Fi transmission and the wired transmission via Ethernet 802.3. Furthermore, wireless transmission via LTE or 4G plus was used by several partners. This resulted in a very broad transmission application scenario. An overview of the transmission technology of the sensor infrastructure to the real-time controller and the forwarding to the real-time visualization is depicted in Figure 4.
Table 1.
Overview of network interface parts used in fast care.
Figure 4.
Network infrastructure [22].
After the data has been transferred to the real-time controller, the data is available in the form of JSON objects that were stored on the Linux system of the server. At the same time, an integrative situation analysis of the sensor data is carried out and the corresponding information is transferred to the real-time visualization via the public network to a cloud server, which generates a website with the correspondingly evaluated real-time data in the form of an Avatar.
2.3 Hardware, sensors, actors
In this part all of the hardware components which have been developed in the project are described. On the one hand, this includes sensors with the task of capturing a physical measured variable like motion, VOC gas, heart rate, etc. Furthermore, sensor modules have been developed with implemented combined sensors which form a functional unit with actuators e.g. the electronically controllable lower leg prosthesis. For a better overview of the components used by the individual partners, a matrix of the use of all partners and their network interfaces was created. (See Table 2).
Kinect
IMUs (Body)
IMUs (Object)
Prothesis
Camera
VOC Sen.
Smart phone
Real-time controller
Cloud
Terminal
HSH
+
+
+
TUD
+
++
+
OvGU
+
+
+
URO
+
+
++++
+++
+++
EX
+++
+
+
++
BST
+
+
OBO
+
++
HO
+
+
+
Table 2.
Types of hardware components used by the cooperation partners.
In the following subsections all of the used hardware and all sensors/actors are collected and described.
2.3.1 AAL lab installation
Rapid and intelligent sensors and actuators, an improvement of motion pattern recognition and intelligent algorithms for real-time network integration in three demonstrators of the AAL-Lab serve as solution approaches. Within the fast care project, a real-time network integration with demonstrators is to be carried out at the AAL-Lab of the Harz University. The various partial results of the project partners have been collected and integrated in the AAL-Lab. The integration at the AAL-Lab will be performed with the focus on user friendliness and the interaction with him by means of a show flat. Figure 5 illustrates the realized structure of the AAL-Lab with various elements for monitoring and evaluation of the measured vital data. The lab includes the following parts: Sensors on the walls: Pulse, Blood pressure, breathing frequency, Motion/position, VOC breath analysis, e-rehabilitation workout and the real-time controller PC.
Figure 5.
AAL lab of the Harz university; sketch of installations; (a) sensors on the walls: Pulse, blood pressure, breathing frequency, skin resistance, motion/position, VOC breath analysis, (b) E-rehabilitation, (c) real-time controller.
In Figure 6 you can see the laboratory, including a sofa, several armchairs, a bed and all the sensor components that were attached to the room, as shown in the Figure 5. The room has been deliberately designed like an old room to create a pleasant atmosphere for the examinations. After the technology was installed, the acceptance tests were carried out in this environment.
Figure 6.
Photograph of AAL lab.
2.3.2 E-rehabilitation system
The Kinect sensor used by the Otto von Guericke University in fast care is a physical device with depth sensor technology, integrated color camera, infrared transmitter and microphone array that detects the position and movement of people and voices. Table 2 shows the data of the KINECT depth sensor, while Figure 7 shows the workout scene. The application is to make a therapeutically workout with the patient and give him in real-time information and helpful feedback to move him in the right way. Additionally, a gait analysis [23, 24] can be performed by the use of IMUs positioned at the feet, shown in Figure 7. More detailed information can be found by Stoutz et al. in [25] (Table 3).
Figure 7.
Setup of the gait measurements for e-rehabilitation of Otto von Guericke university; above left: IMU application at the feet; above right: Therapeutic movements with avatar; lower middle: Presentation of gait analysis measurement.
Optimized 3D visualization, detection of smaller objects in particular and stable body tracking
1080p-Color Camera 30 Hz (15 Hz in poor lighting conditions)
Camera with 1080p resolution
Neue aktive Infrarot-Funktionen 512 × 424, 30 Hz
IR functions for lighting independent observations
Multi-Array-Microphone
Four microphones etc. to find the sound source and the direction of the audio wave
Interfaces
Kinect
AUX (USB)
Kinect2
AUX (USB)
Table 3.
Data of the used KINECT sensor system for e-rehabilitation.
2.3.3 Inertial measurement unit (IMU)
The IMU used by the project partners “Otto Bock HealthCare GmbH”, “Otto von Guericke University” and “University of Rostock” describes an initial measuring unit. It is a self-contained measuring system that continuously records, analyzes, and, if necessary, pre-processes defined physical parameters (e.g. movement, acceleration, pressure, etc.) and forwards them to downstream communication and network protocols (see Figure 8). A distinction is made between two application modes. On the one hand, the IMUs on an object e.g. be installed in a kitchen appliance [26], which describes the use of “IMU on object” and provides measurement data for further analysis. Another area of application is the use of an IMU through suitable holders on the body of a person, which in turn describes the use of the “initial sensor on body” and also provides measurement data for further analysis [27, 28]. The project partner “Bosch Sensortec GmbH” [29, 30] developed and produces the IMU’s used in the fast care project [31].
Figure 8.
Structure of the inertial measurement unit network.
2.3.4 Camera-based vital parameter sensor
The camera-based vital sensors [32, 33] used by the project partner of the “Technical University Dresden” [34, 35, 36] are based on one or more camera systems with an associated, spectrally controllable lighting system and generate a spatial image of the surroundings as a database for further evaluations. Camera-based photoplethysmography (cbPPG) remotely detects the volume pulse of cardiac ejection in the peripheral circulation. The system does measure the heart rate, the breath rate with a camera system contactless in real time. More detailed information’s are described in the work of the Technical University of Dresden, Institute of Biomedical Technologies of Zaunseder et al. [37, 38]. The camera-based system records the change in the movement of the surface of the face in a fast data recording (see Figure 9).
Figure 9.
Camera-based vital sensors, 1 measurement unit, 2: Camera and lighting system 1, 3: Central display of real-time measurement 4: Measurement system 1 while application, 5: Measurement system 2 in while application, 6: Camera and lighting system 2.
The exposure with an LED light source with a special spectral range is necessary to obtain a particularly good contrast. The raw image data are sent directly to a controller and evaluated there. The evaluated data (heart rate, respiratory rate) are transferred directly as a JSON object to the real-time controller via Ethernet cabling at 1 Gb/s and stored there in the MQTT server. The representation of the respiratory rate and the heart rate is then realized in real time in the Avatar (see Sensor Data Visualization 2.4).
2.3.5 VOC air sensor
As part of the BMBF-funded “fast care” project, HarzOptics GmbH [39] has developed components for a distributed sensor network for the spectroscopic analysis of air. The sensor system analyzes the air in a room by measuring the optical spectral content of volatile organic components (VOC) [39, 40, 41, 42]. Special absorptions of VOC gases are analyzed, which indicate the beginning of clinical pictures. In addition to assessing the quality of indoor air for AAL applications, this system is also to be used for the detection of VOC in breathing gas. Since the presence of certain VOCs in exhaled air enables conclusions to be drawn about diseases such as lung cancer or metabolic disorders, the integration of a non-invasive permanent gas analysis in real-time medical care is becoming possible, also in view of increasing bandwidths and decreasing latency times [39].
The air sensor is part of a more complex system, the basic mode of operation of which can be seen in Figure 10. Data recorded by a sensor (e.g. CO2 concentration) are transferred as (voltage) values to an Arduino board, which converts the values into volume concentrations, converts the data generated from it into an MQTT-compliant format and transmits it to a real-time server. The data is displayed using a special real time Avatar sketch which is presented in chapter 4.10 in more detail. If limits are exceeded, a warning or recommendation is issued (e.g. “Please open window and ventilate” or “Please consult a doctor”). In addition to the data from this sensor, the MQTT server also receives data from other sensors that have been developed by other project partners. These are also visualized in the Avatar figure.
Figure 10.
VOC sensor setup.
After the spectrum could not be recorded using an optical spectrometer due to a lack of sensitivity, an alternative setup with laser sources was implemented. The wavelengths used here correspond to the previously determined absorptions of the relevant substances and are recorded by a broadband optical sensor. If the substances sought are present in the air, the light from the laser source is attenuated in accordance with the concentration, which reduces the voltage values at the sensor output and the volume concentration can be determined. The temperature sensitivity of the sensor and amplifier is still causing problems.
2.3.6 Active prothesis
Under the catchphrase “active prosthesis”, “Otto Bock HealthCare GmbH” summarizes its IMUs worn on the body, an associated analysis and evaluation unit and the control of an active prosthetic foot. The aim is to map an automatic adjustment of an active prosthetic foot using a long-term measurement of a gait analysis based on the foot, knee and joint angle. The realization of the complete measurement system is described in more details by Albrecht-Laatsch in [43]. The current status quo for the adaptation of prostheses is that clients rarely come to adapt their prostheses for rehabilitation and check-ups. Therefore, the prosthesis is usually only adapted for one type of gait. In addition, developers rarely speak to users, so that little everyday problems flow into development.
The goal of the development the active prothesis in the fast care project was to get a better picture of the real prosthesis usage, as well as to make it easier and faster to adapt to the real needs of the user. This was achieved with a remote connection of the active prosthetic foot used for remote diagnosis and automatic adaptation to the conditions of use.
Implementation was achieved with the help of motion sensors (IMU), the measured values of which were used both locally and remotely. This eliminates the need for a regular visit to the gait laboratory and the long-term recording takes place in a relaxed environment. In addition, incorrect movement patterns can be recognized and corrected early. The adaptation takes place automatically and can be initiated from a “remote” location. With the active prosthetic foot, the heel height and the active aisle support could be automatically adjusted by the software. This reduces fatigue, as the engine pushes the legs off. The support is regulated depending on the speed. For experts in the laboratory, the gait diagram is displayed remotely in real time, and further parameters of the prosthesis can be remotely adjusted by the experts in fine tuning mode. The test of the automatic adaptation of the was performed in the laboratory which is depicted in the working scene of Figure 11.
Figure 11.
Active prothesis motion sensor with feedback for gait optimization.
2.3.7 Bluetooth beacons
The University of Rostock uses “bulky BLE Beacons” to locate its IMUs in the room [27, 28]. These beacons are distributed in a fixed position in the room and allow the IMU’s to make statements about movements in the space of people and their acceleration via a field strength measurement. The sensors provide information about using a kitchen task assessment dataset. This dataset contains normal behavior as well as erroneous behavior due to dementia, recorded with wearable sensors as well as with sensors attached to objects. The scene of the application of the kitchen task workout is depicted Figure 12.
Figure 12.
Motion analysis of a cooking process with IMUs with inference method at university Rostock.
In this workout, a test client prepares a pudding meal that is clearly defined in a few simple steps. The process goes through the compilation of the ingredients, the cooking itself to completion and decanting the pudding into several cups. All sub-processes are analyzed in detail and provided with appropriate help if the wrong ingredients are used or the wrong wooden spoon, while all objects in the environment which the person is working, are connected with IMU sensors.
The kitchen task is created by a semantic annotation scheme. This scheme gives information about the observed motions and the errors while performing the workout. The data format splits in sensor and video data. The video data are collected by several cameras while the sensor data are collecting parallel to the video several accelerations from the IMU sensors fixed at the body worn sensors and additional from the used objects. The complete data roll consists of several normal and false runs. To get information about the false runs, the clients realized errors in the workout. The data consists of action data as well as the object being manipulated and the client that is working with it. More information about the sensor application to analyze the erroneous behavior from Hein et al. can be found in [44].
2.3.8 Emergency button and temperature/humidity sensors
As an additional sensor system, the Exelonix company implemented an NbIoT sensor as a push button, which transmits its sensor data in JSON format to the real-time server via the public network via the existing 4G + radio network (see Figure 13). The emergency is displayed in real time on the visualization server. In the real case, this could then be transmitted to the 24/7 service of a nursing service. A second sensor that also works via NbIoT transmission is a motion-sensitive sensor. This has been installed to register movements in the room and additionally to transmit the room temperature and air pressure to the real-time server via the public radio network. In this case, too, the data is transmitted in JSON format. Further information on the exact key data of the sensors can be found in the publications by Stege et al. [45, 46, 47, 48].
Figure 13.
Sensor modules of Exelonix, left: IoT emergency button via 4G+; right: IoT temperature, air pressure and motion sensor via 4G+.
2.3.9 Real-time controller
Within the fast care project, the Harz University of Applied Sciences developed a real-time platform for the sensor data fusion of the partial realizations of the partners. For this purpose, a Linux-based application server was configured based on a communication protocol (MQTT) selected for the project. This “real-time controller”, on which all information converges, forms the central “sensor data fusion”. The device includes a rack mounted server PC with Intel I7 topology and a memory of 16 GByte 1600 MHz DDR3 which is depicted in Figure 14. The LINUX version is “Red Hat Enterprise Linux Server release 7.7 (Maipo)”. The network interfaces are two 1 GB IEEE 802.3 and a “Realtek Semiconductor Co., Ltd. RTL8192EE PCIe Wireless Network Adapter”. More detailed information can be found in [21] the so called final design plan of the fast care project.
Figure 14.
Real-time controller with MQTT server.
2.4 Sensor data visualization
The project partners agreed to the technical implementation of the data fusion on the planned real-time server and the development of a user interface. After the data collection of all partners, these data are evaluated centrally on the real-time controller. The user should receive feedback about the obtained information. This feedback is based on the visualization of the situation analysis. The main view of the real-time visualization is shown in Figure 15. With its end customer platform, Exelonix GmbH forms the technological basis for the visualization in the fast care project. All sensor data collected in the MQTT server of the Harz University of Applied Sciences are evaluated using the Axel Onyx and Customer Platform, and all sensor data collected in the MQTT server of the Harz University are collected using the end customer platform from Exelonix. The sensor data were evaluated and visualized in a web page to which only the project partners had access. The transformation and preparation of the “technical information and data packets” received on the “real-time controller” was realized into a form that can be interpreted by those in need of care, relatives and experts. Among other things, time courses and histories are added.
Figure 15.
Real-time visualization of the measured sensor data.
The visualization is shown in Figure 15. An Avatar appears on the left, in which both, the heart rate and the breathing rate are shown optically in a movement of the heart and chest. On the right side of the picture there is a heart with the heart rate and with a lung that the respiratory rate. Furthermore, the data of the Exelonix sensor as well as the emergency button status, the room temperature and the room humidity are shown. An indication of the condition of the indoor air is shown directly below these displays, in this case the icon of a green cloud shows that the indoor air is in good condition.
Additional sensor data is depicted on the Avatar sketch. In the hip, knee and ankle area of the legs, the information about the energetic states of the batteries of the IMUs for recording the posture and knee angle is shown. The measured knee angle from the leg with the prosthesis is shown online in the graphic on the right, where the knee angle is shown in degrees over time while walking.
The measurement of the gait parameters of the patient, which is also recorded by the IMUs on the hips, knees and ankles (see Section 2.3.3), can be seen online to the right of the two icons on the gait width and lifting height of the foot. This allows the gait to be assessed and improved in situ for rehabilitation purposes.
In addition to this main page of the real-time display, a sub-page has been created for each application of the partners, in which the details of the individual sensor elements and their operation are compressed. The details of the real-time visualization of the partners can be seen especially in the final design plan, which can be found in the publication of Kußmann et al. [21].
3. User acceptance studies
In addition to the technical development activities, an analysis of acceptance was executed at the AAL-Lab of the Harz University. As a result of the project, fast care wants to develop feasible products and create the medical fundamentals for an interaction (feedback) in real time.
The project partners agreed to the technical implementation of the data fusion on the planned real-time server and the development of a user interface. This is done in addition to the workload of the integration of all technical components and the planed example application. After the data collection of all partners, these data are evaluated centrally on the real-time controller. The user should receive feedback about the obtained information. This feedback is based on the visualization of the situation analysis.
In the analysis of acceptance of the system, a small sample of a total of 20 subjects from different age groups was interviewed. The following figure shows the distribution by gender and age (Figure 16). Although this study is not representative, it gives a first insight into the valuation of the developed technology.
Figure 16.
Age and gender distribution of the testing persons.
During the survey, the subjects had to assess both the individual systems of the project partners and the overall system. The survey results of the entire system were very positive. 60% of the respondents stated, that they would like to use the technology privately, 70% of the respondents would like to have access to the technology, 35% would be willing to buy the presented technology and 95% see a great benefit for themselves and for others in the tested technology (see Figure 17).
Figure 17.
Use of the presented technologies.
In another part of the test, the sample’s affinity for technology was queried. On average, the confidence “in your own skills” when dealing with new technology was rated with 3.33 out of 5 points, the willingness to use new and unknown technology with 4 out of 5 points and the degree of technical overload with only 2.13 out of 5 Points. As a result, the test subjects showed a great willingness to use new technologies and did not feel overwhelmed with the used technology (see Figure 18).
Figure 18.
Technical affinity of the test persons.
Figure 19 illustrates, that the subsystem of the project partner Otto Bock was rated positively by the test subjects. The success of the measurement was rated on average with 4.35 out of 5 points, the success of the calibration with 3.97 out of 5 points and the intelligibility of the display with 3.27 out of 5 points. The women rated the manageability of the system with 4.08 out of 5 points slightly better than the men with 3.44 out of 5 points.
Figure 19.
Evaluation of the application of the active prothetic foot.
The gait analysis of the project partner of the Otto von Guericke University was rated as very positive by the subjects with 4.27 out of 5 points. The technology used by the OvGU Kinect system with 3.9 out of 5 points. The more the test subjects were overwhelmed with the technology, the more negative the system was rated (see Figure 20).
Figure 20.
Evaluation of the applications of the demonstrators of OvGU and TU Dresden.
Analyzing the system of the TU Dresden, the success of the measurement was rated 4.05 out of 5 points and the comprehensibility of the instructions with 4.05 out of 5 points. The comprehensibility of the instructions was more incomprehensible for the test subjects when they were overwhelmed by the technology. The intelligibility of the display and the results was rated with 3.58 out of 5 points (see Figure 20).
4. Conclusions
In the project fast care, a real-time capable sensor data analysis-framework in the fields of ambient assisted living was developed. The project realized a medical valid integrated real-time picture of the patient’s situation by using several interconnected sensor-actor infrastructures with a latency period of less than 10 ms. The implemented sensor structure records the heart rate, the breathing rate, the VOC content of the room air, analyzes the gait for rehabilitation and measures the temperature and humidity in the room. An emergency button has also been integrated.
An active prosthetic foot was used as a special application of the sensor-actor System. Its running parameters can be measured online, and the prosthesis can automatically adapt to the floor covering and the running demands via the network. This means that users have an intelligent active prosthesis at their disposal to help them cope with everyday life more easily.
It was shown that even with a heterogeneous network consisting of the components WiFi, Bluetooth LE, Gigabit LAN and 4G+, real-time operation was possible for the use of the AAL components. Even the display of the measured data, which was transferred to a website via the cloud, only showed latencies of an additional few milliseconds. This made it possible to create a real-time image in the form of an Avatar for all vital parameters and the automatic setting of the active prosthetic foot, which enables the client to notice his physical condition in situ.
In addition to the technical development activities, an analysis of acceptance was executed at the demonstrator in the AAL-laboratory. The survey results of the entire system were very positive. 60% of the respondents stated, that they would like to use the technology privately, 70% of the respondents would like to have access to the technology, 35% would be willing to buy the presented technology and 95% see a great benefit for themselves and for others in the tested technology.
Unfortunately, some slow network technologies such as Bluetooth LE had to be used to carry out the project. It is to be expected, that with the full expansion of the networks to the fifth generation (5G), there will still be a significant leap in transmission speed and transmission quality. It is therefore to be expected that eHealth applications in the home area can be implemented in real time in the near future. After the data fusion, further processing with the help of the artificial intelligence will bring further benefits to the client for the prevention of his physical and mental health.
Acknowledgments
The fast care project was supported by the German Federal Ministry of Education and Research in the program “Zwanzig20 – Partnerschaft für Innovation”, contract no. 03ZZ0519I. It was carried out in the form of a joint project with eight partners and a project coordinator. We thank all fast care project partners for their contributions to this work personally listed in the following: Thomas Kirste, Christian Haubelt, Albert Hein, Florian Grützmacher from University Rostock, Ernst Albrecht-Laatsch, Bernhard Graimann, Martin Schmidt and Katharina Olze from Ottobock, Alexander Trumpp, Daniel Wedekind, Martin Schmidt, Sebastian Zaunseder, Hagen Malberg from Technische Universität Dresden, Christian Reinboth and Jens-Uwe Just from HarzOptics, Matthias Stege, Frank Schäfer, Tristan Heinig and Sascha Huth from Exelonix, Rainer Dorsch from Bosch Sensortec, Lutz Schega, Sebastian Stoutz and Kim-Charline Broscheid from Otto-von-Guericke-Universität Magdeburg.
\n',keywords:"ambient assisted living technologies, eHealth, eCare, tele-care, real-time networks, vital data acquisition, fast project",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73411.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73411.xml",downloadPdfUrl:"/chapter/pdf-download/73411",previewPdfUrl:"/chapter/pdf-preview/73411",totalDownloads:302,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:49,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"February 13th 2020",dateReviewed:"August 25th 2020",datePrePublished:null,datePublished:"March 17th 2021",dateFinished:"September 30th 2020",readingETA:"0",abstract:"In the industrialized countries, the very old part of the population has been growing rapidly for many years. In the next few years in particular, the age cohort over 65 will increase significantly. This goes hand in hand with illnesses and other physical and cognitive limitations. In order to enable these people to remain in their own homes for as long as possible despite physical and cognitive restrictions, technologies are being used to create ambient assisted living applications. However, most of these systems are neither medically verified nor are latencies short enough, for example, to avoid falls. In order to overcome these problems, a promising approach is to use the new 5G network technology. Combined with a suitable sensor data analysis frame work, the fast care project showed that a real-time situation picture of the patient in the form of an Avatar could be generated. The sensor structure records the heart rate, the breathing rate, analyzes the gait and measures the temperature, the VOC content of the room air, and its humidity. An emergency button has also been integrated. In a laboratory demonstrator, it was shown that the infrastructure realizes a real-time visualization of the sensor data over a heterogeneous network.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73411",risUrl:"/chapter/ris/73411",book:{id:"9973",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering"},signatures:"Ulrich H.P. Fischer, Sabrina Hoppstock, Peter Kußmann and Isabell Steuding",authors:[{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",fullName:"Ulrich H.P Fischer",slug:"ulrich-h.p-fischer",email:"ufischerhirchert@hs-harz.de",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",institution:{name:"Charité",institutionURL:null,country:{name:"Germany"}}},{id:"318655",title:"MSc.",name:"Sabrina",middleName:null,surname:"Hoppstock",fullName:"Sabrina Hoppstock",slug:"sabrina-hoppstock",email:"Hoppstock.sabrina@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",fullName:"Peter Kußmann",slug:"peter-kussmann",email:"pkussmann@hs-harz.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Harz University of Applied Sciences",institutionURL:null,country:{name:"Germany"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",fullName:"Isabell Steuding",slug:"isabell-steuding",email:"isteuding@hs-harz.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Harz University of Applied Sciences",institutionURL:null,country:{name:"Germany"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Technical goals and solutions",level:"1"},{id:"sec_2_2",title:"2.1 System setup",level:"2"},{id:"sec_3_2",title:"2.2 Technological concept",level:"2"},{id:"sec_4_2",title:"2.3 Hardware, sensors, actors",level:"2"},{id:"sec_4_3",title:"2.3.1 AAL lab installation",level:"3"},{id:"sec_5_3",title:"Table 3.",level:"3"},{id:"sec_6_3",title:"2.3.3 Inertial measurement unit (IMU)",level:"3"},{id:"sec_7_3",title:"2.3.4 Camera-based vital parameter sensor",level:"3"},{id:"sec_8_3",title:"2.3.5 VOC air sensor",level:"3"},{id:"sec_9_3",title:"2.3.6 Active prothesis",level:"3"},{id:"sec_10_3",title:"2.3.7 Bluetooth beacons",level:"3"},{id:"sec_11_3",title:"2.3.8 Emergency button and temperature/humidity sensors",level:"3"},{id:"sec_12_3",title:"2.3.9 Real-time controller",level:"3"},{id:"sec_14_2",title:"2.4 Sensor data visualization",level:"2"},{id:"sec_16",title:"3. User acceptance studies",level:"1"},{id:"sec_17",title:"4. 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A high sensitivity and wide dynamic range fiber-optic sensor for low-concentration VOC gas detection. Sensors. 2014;14(12):23321-23336. Available from: http://www.mdpi.com/1424-8220/14/12/23321/'},{id:"B43",body:'Albrecht-laatsch E, Szufnarowski F. Optimization of dynamic properties of exo-prostheses using a distributed inertial measurement system. In: Jahrestagung der deutschen Gesellschaft für Biomedizinishe Technik DGBMT. Dresden: Saxony; 2017. p. 86. Available from: https://www.vde.com/resource/blob/1645606/36a6dc49966d0b0196c7ddca0c52de8f/bmt2017-dgbmt-jahrestagung-programm-data.pdf'},{id:"B44",body:'Yordanova K, Hein A, Kirste T. Kitchen Task Assessment Dataset for Measuring Errors Due to Cognitive Impairments. 2020 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops), Austin, TX, USA. 2010. pp. 1-6. DOI: 10.1109/PerComWorkshops48775.2020.9156115'},{id:"B45",body:'Stege M. Requirements of low latency sensor/actuator networks for e-health applications. In: Jahrestagung der BIOMEDIZINISCHEN TECHNIK und Dreiländertagung der MEDIZINISCHEN PHYSIK. Dresden: DGBMT; 2017. p. FS89. Available from: https://www.vde.com/resource/blob/1645606/36a6dc49966d0b0196c7ddca0c52de8f/bmt2017-dgbmt-jahrestagung-programm-data.pdf'},{id:"B46",body:'Matz AP, Fernandez-Prieto J-A, Cañada-Bago J, Birkel UA. Systematic analysis of narrowband IoT quality of service. Sensors. 2020;20:1636-1642'},{id:"B47",body:'Sunyaev A. The internet of things. In: Internet Computing. Heidelberg: Springer; 2020. DOI: 10.1007/978-3-030-34957-8_10'},{id:"B48",body:'Exelonix. IoT – Services & Applications E-Health Appications [Internet]. 2020. Available from: https://www.exelonix.com/services_englisch/'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ulrich H.P. Fischer",address:"ufischerhirchert@hs-harz.de",affiliation:'
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\n
1. Introduction
\n
Kalman filtering is an algorithm that provides estimates of some unknown variables given the measurements observed over time. Kalman filters have been demonstrating its usefulness in various applications. Kalman filters have relatively simple form and require small computational power. However, it is still not easy for people who are not familiar with estimation theory to understand and implement the Kalman filters. Whereas there exist some excellent literatures such as [1] addressing derivation and theory behind the Kalman filter, this chapter focuses on a more practical perspective.
\n
Following two chapters will devote to introduce algorithms of Kalman filter and extended Kalman filter, respectively, including their applications. With linear models with additive Gaussian noises, the Kalman filter provides optimal estimates. Navigation with a global navigation satellite system (GNSS) will be provided as an implementation example of the Kalman filter. The extended Kalman filter is utilized for nonlinear problems like bearing-angle target tracking and terrain-referenced navigation (TRN). How to implement the filtering algorithms for such applications will be presented in detail.
\n
\n
\n
2. Kalman filter
\n
\n
2.1 Problem definition
\n
Kalman filters are used to estimate states based on linear dynamical systems in state space format. The process model defines the evolution of the state from time \n\nk\n−\n1\n\n to time \n\nk\n\n as:
where \n\nF\n\n is the state transition matrix applied to the previous state vector \n\n\nx\n\nk\n−\n1\n\n\n\n, \n\nB\n\n is the control-input matrix applied to the control vector \n\n\nu\n\nk\n−\n1\n\n\n\n, and \n\n\nw\n\nk\n−\n1\n\n\n\n is the process noise vector that is assumed to be zero-mean Gaussian with the covariance \n\nQ\n\n, i.e., \n\n\nw\n\nk\n−\n1\n\n\n∼\nN\n\n0\nQ\n\n\n.
\n
The process model is paired with the measurement model that describes the relationship between the state and the measurement at the current time step \n\nk\n\n as:
\n\n\nz\nk\n\n=\nH\n\nx\nk\n\n+\n\nν\nk\n\n\nE2
\n
where \n\n\nz\nk\n\n\n is the measurement vector, \n\nH\n\n is the measurement matrix, and \n\n\nν\nk\n\n\n is the measurement noise vector that is assumed to be zero-mean Gaussian with the covariance \n\nR\n\n, i.e., \n\n\nν\nk\n\n∼\nN\n\n0\nR\n\n\n. Note that sometimes the term “measurement” is called “observation” in different literature.
\n
The role of the Kalman filter is to provide estimate of \n\n\nx\nk\n\n\n at time \n\nk\n\n, given the initial estimate of \n\n\nx\n0\n\n\n, the series of measurement, \n\n\nz\n1\n\n,\n\nz\n2\n\n,\n…\n,\n\nz\nk\n\n\n, and the information of the system described by \n\nF\n\n, \n\nB\n\n, \n\nH\n\n, \n\nQ\n\n, and \n\nR\n\n. Note that subscripts to these matrices are omitted here by assuming that they are invariant over time as in most applications. Although the covariance matrices are supposed to reflect the statistics of the noises, the true statistics of the noises is not known or not Gaussian in many practical applications. Therefore, \n\nQ\n\n and \n\nR\n\n are usually used as tuning parameters that the user can adjust to get desired performance.
\n
\n
\n
2.2 Kalman filter algorithm
\n
Kalman filter algorithm consists of two stages: prediction and update. Note that the terms “prediction” and “update” are often called “propagation” and “correction,” respectively, in different literature. The Kalman filter algorithm is summarized as follows:
In the above equations, the hat operator, \n\n̂\n\n, means an estimate of a variable. That is, \n\n\nx\n̂\n\n\n is an estimate of \n\nx\n\n. The superscripts \n\n–\n\n and \n\n+\n\n denote predicted (prior) and updated (posterior) estimates, respectively.
\n
The predicted state estimate is evolved from the updated previous updated state estimate. The new term \n\nP\n\n is called state error covariance. It encrypts the error covariance that the filter thinks the estimate error has. Note that the covariance of a random variable \n\nx\n\n is defined as \n\ncov\n\nx\n\n=\nE\n\n\n\n\n\nx\n−\n\nx\n̂\n\n\n\n\n\n\nx\n−\n\nx\n̂\n\n\n\nT\n\n\n\nT\n\n\n where \n\nE\n\n denotes the expected (mean) value of its argument. One can observe that the error covariance becomes larger at the prediction stage due to the summation with \n\nQ\n\n, which means the filter is more uncertain of the state estimate after the prediction step.
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In the update stage, the measurement residual \n\n\n\ny\n∼\n\nk\n\n\n is computed first. The measurement residual, also known as innovation, is the difference between the true measurement, \n\n\nz\nk\n\n\n, and the estimated measurement, \n\nH\n\n\nx\n̂\n\nk\n−\n\n\n. The filter estimates the current measurement by multiplying the predicted state by the measurement matrix. The residual, \n\n\n\ny\n∼\n\nk\n\n\n, is later then multiplied by the Kalman gain, \n\n\nK\nk\n\n\n, to provide the correction, \n\n\nK\nk\n\n\n\ny\n∼\n\nk\n\n\n, to the predicted estimate \n\n\n\nx\n̂\n\nk\n−\n\n\n. After it obtains the updated state estimate, the Kalman filter calculates the updated error covariance, \n\n\nP\nk\n+\n\n\n, which will be used in the next time step. Note that the updated error covariance is smaller than the predicted error covariance, which means the filter is more certain of the state estimate after the measurement is utilized in the update stage.
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We need an initialization stage to implement the Kalman filter. As initial values, we need the initial guess of state estimate, \n\n\n\nx\n̂\n\n0\n+\n\n\n, and the initial guess of the error covariance matrix, \n\n\nP\n0\n+\n\n\n. Together with \n\nQ\n\n and \n\nR\n\n, \n\n\n\nx\n̂\n\n0\n+\n\n\n and \n\n\nP\n0\n+\n\n\n play an important role to obtain desired performance. There is a rule of thumb called “initial ignorance,” which means that the user should choose a large \n\n\nP\n0\n+\n\n\n for quicker convergence. Finally, one can obtain implement a Kalman filter by implementing the prediction and update stages for each time step, \n\nk\n=\n1\n,\n2\n,\n3\n,\n…\n\n, after the initialization of estimates.
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Note that Kalman filters are derived based on the assumption that the process and measurement models are linear, i.e., they can be expressed with the matrices \n\nF\n\n, \n\nB\n\n, and \n\nH\n\n, and the process and measurement noise are additive Gaussian. Hence, a Kalman filter provides optimal estimate only if the assumptions are satisfied.
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2.3 Example
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An example for implementing the Kalman filter is navigation where the vehicle state, position, and velocity are estimated by using sensor output from an inertial measurement unit (IMU) and a global navigation satellite system (GNSS) receiver. In this example, we consider only position and velocity, omitting attitude information. The three-dimensional position and velocity comprise the state vector:
\n\nx\n=\n\n\n\np\nT\n\n\nv\nT\n\n\nT\n\n\nE3
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where \n\np\n=\n\n\n\np\nx\n\n\np\ny\n\n\np\nz\n\n\nT\n\n\n is the position vector and \n\nv\n=\n\n\n\nv\nx\n\n\nv\ny\n\n\nv\nz\n\n\nT\n\n\n is the velocity vector whose elements are defined in x, y, z axes. The state in time \n\nk\n\n can be predicted by the previous state in time \n\nk\n−\n1\n\n as:
where \n\n\nI\n\n3\n×\n3\n\n\n\n and \n\n\n0\n\n3\n×\n3\n\n\n\n denote \n\n3\n×\n3\n\n identity and zero matrices, respectively. The process noise comes from the accelerometer output, \n\n\na\n\nk\n−\n1\n\n\n=\n\n\na\n∼\n\n\nk\n−\n1\n\n\n+\n\ne\n\nk\n−\n1\n\n\n\n, where \n\n\ne\n\nk\n−\n1\n\n\n\n denotes the noise of the accelerometer output. Suppose \n\n\ne\n\nk\n−\n1\n\n\n∼\nN\n\n0\n\n\nI\n\n3\n×\n3\n\n\n\nσ\ne\n2\n\n\n\n\n. From the covariance relationship, \n\nCov\n\n\nA\nx\n\n\n=\nAΣ\n\nA\nT\n\n\n where \n\nCov\n\nx\n\n=\nΣ\n\n, we get the covariance matrix of the process noise as:
It is straightforward to derive the measurement model as:
\n\n\nz\nk\n\n=\nH\n\nx\nk\n\n+\n\nν\nk\n\n\nE12
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where
\n\nH\n=\n\nI\n\n6\n×\n6\n\n\n\nE13
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\n\n\nν\nk\n\n∼\nN\n\n0\nR\n\n\nE14
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In order to conduct a simulation to see how it works, let us consider \n\nN\n=\n20\n\n time steps (\n\nk\n=\n1\n,\n2\n,\n3\n,\n…\n,\nN\n)\n\n with \n\nΔt\n=\n1\n\n. It is recommended to generate a time history of true state, or a true trajectory, first. The most convenient way is to generate the series of true accelerations over time and integrate them to get true velocity and position. In this example, the true acceleration is set to zero and the vehicle is moving with a constant velocity, \n\n\nv\nk\n\n=\n\n\n5\n5\n0\n\nT\n\n\n for all \n\nk\n=\n1\n,\n2\n,\n3\n,\n…\n,\nN\n\n, from the initial position, \n\n\np\n0\n\n=\n\n0\n0\n0\n\n\n. Note that one who uses the Kalman filter to estimate the vehicle state is usually not aware whether the vehicle has a constant velocity or not. This case is not different from nonzero acceleration case in perspective of this Kalman filter models. If the filter designer (you) has some prior knowledge of the vehicle maneuver, process models can be designed in different forms for best describing various maneuvers as in [2].
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We need to generate noise of acceleration output and GNSS measurements for every time step. Suppose the acceleration output, GNSS position, and GNSS velocity are corrupted with noise with variances of 0.32, 32, and 0.032, respectively. For each axis, one can use MATLAB function randn or normrnd for generating the Gaussian noise.
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The process noise covariance matrix, \n\nQ\n\n, and measurement noise covariance matrix, \n\nR\n\n, can be constructed following the real noise statistics described above to get the best performance. However, have in mind that in real applications, we do not know the real statistics of the noises and the noises are often not Gaussian. Common practice is to conservatively set \n\nQ\n\n and \n\nR\n\n slightly larger than the expected values to get robustness.
where \n\nQ\n\n and \n\nR\n\n are constant for every time step. The more uncertain your initial guess for the state is, the larger the initial error covariance should be.
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In this simulation, \n\nM\n=\n100\n\n Monte-Carlo runs were conducted. A single run is not sufficient for verifying the statistic characteristic of the filtering result because each sample of a noise differs whenever the noise is sampled from a given distribution, and therefore, every simulation run results in different state estimate. The repetitive Monte-Carlo runs enable us to test a number of different noise samples for each time step.
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The time history of estimation errors of two Monte-Carlo runs is depicted in Figure 1. We observe that the estimation results of different simulation runs are different even if the initial guess for the state estimate is the same. You can also run the Monte-Carlo simulation with different initial guesses (sampled from a distribution) for the state estimate.
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Figure 1.
Time history of estimation errors.
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The standard deviation of the estimation errors and the estimated standard deviation for x-axis position and velocity are drawn in Figure 2. The standard deviation of the estimation error, or the root mean square error (RMSE), can be obtained by computing standard deviation of \n\nM\n\n estimation errors for each time step. The estimated standard deviation was obtained by taking squared root of the corresponding diagonal term of \n\n\nP\nk\n+\n\n\n. Drawing the estimated standard deviation for each axis is possible because the state estimates are independent to each other in this example. A care is needed if \n\n\nP\nk\n+\n\n\n has nonzero off-diagonal terms. The estimated standard deviation and the actual standard deviation of estimate errors are very similar. In this case, the filter is called consistent. Note that the estimated error covariance matrix is affected solely by \n\n\nP\n0\n+\n\n\n, \n\nQ\n\n, and \n\nR\n\n, judging from the Kalman filter algorithm. Different settings to these matrices will result in different \n\n\nP\nk\n+\n\n\n and therefore different state estimates.
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Figure 2.
Actual and estimated standard deviation for x-axis estimate errors.
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In real applications, you will be able to acquire only the estimated covariance because you will hardly have a chance to conduct Monte-Carlo runs. Also, getting a good estimate of \n\nQ\n\n and \n\nR\n\n is often difficult. One practical approach to estimate the noise covariance matirces is the autocovariance least-squares (ALS) technique [3] or an adaptive Kalman filter where the noise covariance matrices are adjusted in real time can be used [4].
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Source code of MATLAB implementation for this example can be found in [5]. It is recommended for the readers to change the parameters and aircraft trajectory by yourself and see what happens.
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3. Extended Kalman filter
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3.1 Problem definition
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Suppose you have a nonlinear dynamic system where you are not able to define either the process model or measurement model with multiplication of vectors and matrices as in (1) and (2). The extended Kalman filter provides us a tool for dealing with such nonlinear models in an efficient way. Since it is computationally cheaper than other nonlinear filtering methods such as point-mass filters and particle filters, the extended Kalman filter has been used in various real-time applications like navigation systems.
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The extended Kalman filter can be viewed as a nonlinear version of the Kalman filter that linearized the models about a current estimate. Suppose we have the following models for state transition and measurement
where \n\nf\n\n is the function of the previous state, \n\n\nx\n\nk\n−\n1\n\n\n\n, and the control input, \n\n\nu\n\nk\n−\n1\n\n\n\n, that provides the current state \n\n\nx\nk\n\n\n. \n\nh\n\n is the measurement function that relates the current state, \n\n\nx\nk\n\n\n, to the measurement \n\n\nz\nk\n\n\n. \n\n\nw\n\nk\n−\n1\n\n\n\n and \n\n\nν\nk\n\n\n are Gaussian noises for the process model and the measurement model with covariance \n\nQ\n\n and \n\nR\n\n, respectively.
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3.2. Extended Kalman filter algorithm
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All you need is to obtain the Jacobian matrix, first-order partial derivative of a vector function with respect to a vector, of each model in each time step as:
Note the subscripts of \n\nF\n\n and \n\nH\n\n are maintained here since the matrices are often varying with different values of the state vector for each time step. By doing this, you linearize the models about the current estimate. The filter algorithm is very similar to Kalman filter.
As in the Kalman filter algorithm, the hat operator, \n\n̂\n\n, means an estimate of a variable. That is, \n\n\nx\n̂\n\n\n is an estimate of \n\nx\n\n. The superscripts \n\n–\n\n and \n\n+\n\n denote predicted (prior) and updated (posterior) estimates, respectively. The main difference from the Kalman filter is that the extended Kalman filter obtains predicted state estimate and predicted measurement by the nonlinear functions \n\nf\n\n\nx\n\nk\n−\n1\n\n\n\nu\n\nk\n−\n1\n\n\n\n\n and \n\nh\n\n\nx\nk\n\n\n\n, respectively.
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3.3 Example
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3.3.1 Target tracking
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We are going to estimate a 3-dimensional target state (position and velocity) by using measurements provided by a range sensor and an angle sensor. For example, a radar system can provide range and angle measurement and a combination of a camera and a rangefinder can do the same. We define the target state as:
\n\nx\n=\n\n\n\np\nT\n\n\nv\nT\n\n\nT\n\n\nE23
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where \n\np\n\n and \n\nv\n\n denote position and velocity of the target, respectively. The system model is described as a near-constant-velocity model [2] in discrete time space by:
and \n\n\nσ\nx\n\n,\n\nσ\ny\n\n,\n\n and \n\n\nσ\nz\n\n\n are the standard deviations of the process noise on the velocity in x, y, and z directions, respectively.\n
The measurement vector is composed of line-of-sight angles to the target, \n\nA\n\n and \n\nE\n\n, and the range, \n\nR\n\n, to the target. The relationship between the measurement and the relative target state with respect to the sensor comprises the measurement model as:
where \n\n\np\nk\n\n=\n\n\n\nx\nt\n\n\ny\nt\n\n\nz\nt\n\n\nT\n\n\n is the position vector of the target and \n\n\n\n\nx\ns\n\n\ny\ns\n\n\nz\ns\n\n\nT\n\n\n is the position vector of the sensor. The target position is the variable in this measurement model. Note that the measurement has nonlinear relationship with the target state. This cannot be expressed in a matrix form as in (2) whereas the process model can be. If at least one model is nonlinear, we should use nonlinear filtering technique. In order to apply extended Kalman filter to this problem, let us take first derivatives of the process model and measurement model as:
where \n\n\n\nx\ny\nz\n\nT\n\n=\n\n\n\n\nx\nt\n\n−\n\nx\ns\n\n\n\n\ny\nt\n\n−\n\ny\ns\n\n\n\n\nz\nt\n\n−\n\nz\ns\n\n\n\nT\n\n\n is the relative position vector. Note that the matrix \n\n\nH\nk\n\n\n varies with different values of \n\n\n\nx\ny\nz\n\nT\n\n\n on which the filtering result will, therefore, depend. Thus, one can plan the trajectory of the sensor to get a better filtering result [6]. Developing such a method is one of active research topics.
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In the simulation, the sensor is initially located at \n\n\n\n\nx\ns\n\n\ny\ns\n\n\nz\ns\n\n\nT\n\n=\n\n\n40\n20\n50\n\nT\n\n\n and the sensor is moving in a circular pattern with a radius of 20 centered at \n\n\n\n20\n20\n50\n\nT\n\n\n. The initial state of the target is \n\n\nx\n0\n\n=\n\n\n10\n\n−\n10\n\n0\n\n−\n1\n\n\n−\n2\n\n0\n\nT\n\n\n. The sensor is moving with a constant velocity of \n\n\n\n\n−\n1\n\n\n−\n2\n\n0\n\nT\n\n\n. The trajectory of the target and the sensor is shown in Figure 3. Note that this is the case where we are aware that the target has a constant velocity, unlike the example in Section 2.3, which is why we modeled the state transition as the near-constant-velocity model in (4). Let us consider \n\nN\n=\n20\n\n time steps (\n\nk\n=\n1\n,\n2\n,\n3\n,\n…\n,\nN\n)\n\n with \n\nΔt\n=\n1\n\n. Suppose the measurements are corrupted with a Gaussian noise whose standard deviation is \n\n\n\n0.02\n0.02\n1.0\n\nT\n\n\n.
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Figure 3.
Trajectory of the sensor and the target.
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In the filter side, the covariance matrix for the process noise can be set as:
where \n\n\nσ\nv\n\n=\n5\n\n is the tuning parameter that denotes how uncertain the velocity estimate is. The measurement covariance matrix was constructed following the real noise statistics as:
The above equation means that the error of the initial guess for the target state is randomly sampled from a Gaussian distribution with a standard deviation of \n\n\n1\n1\n0\n0\n0\n0\n\n\n.
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Time history of an estimation result for x-axis position and velocity is drawn together with the true value in Figure 4. The shape of the line will be different at each run. The statistical result can be shown as Figure 5. Note that the filter worked inconsistently with the estimated error covariance different from the actual value. This is because the process error covariance is set to a very large number. In this example, the large process error covariance is the only choice a user can make because the measurement cannot correct the velocity. One can notice that the measurement Eq. (26) has no term dependent on the velocity, and therefore, matrix \n\nH\n\n in (28) has zero elements on the right side of the matrix where the derivatives of the measurement equation with respect to velocity are located. As a result, the measurement residual has no effect on velocity correction. In this case, we say the system has no observability on velocity. In practice, this problem can be mitigated by setting the process noise covariance to a large number so that the filter believes the measurement is more reliable. In this way, we can prevent at least the position estimate from diverging.
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Figure 4.
Time history of an estimation result for x-axis position and velocity.
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Figure 5.
Actual and estimated standard deviation for x axis estimate errors.
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Source code of MATLAB implementation for this example can be found in [5]. It is recommended for the readers to change the parameters and trajectories by yourself and see what happens.
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3.3.2 Terrain-referenced navigation
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Terrain-referenced navigation (TRN), also known as terrain-aided navigation (TAN), provides positioning data by comparing terrain measurements with a digital elevation model (DEM) stored on an on-board computer of an aircraft. The TRN algorithm blends a navigational solution from an inertial navigation system (INS) with the measured terrain profile underneath the aircraft. Terrain measurements have generally been obtained by using radar altimeters. TRN systems using cameras [7], airborne laser sensors [8], and interferometric radar altimeters [9] have also been addressed. Unlike GNSS’s, TRN systems are resistant to electronic jamming and interference, and are able to operate in a wide range of weather conditions. Thus, TRN systems are expected to be alternative/supplement systems to GNSS’s.
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The movement of the aircraft is modeled by the following Markov process:
where \n\n\nx\n\nk\n−\n1\n\n\n\n, \n\n\nu\n\nk\n−\n1\n\n\n\n, and \n\n\nw\n\nk\n−\n1\n\n\n\n denote the state vector, the relative movement, and the additive Gaussian process noise, respectively, at time \n\nk\n−\n1\n\n. \n\n\nx\nk\n\n=\n\n\nϕ\nλ\n\nT\n\n\n is a two-dimensional state vector, which denotes the aircraft’s horizontal position. Estimates of the relative movement (velocity) are provided by the INS and their error is absorbed into \n\n\nw\n\nk\n−\n1\n\n\n\n to limit the dimensionality of the state. The simple model in (33) is considered realistic without details of INS integration if an independent attitude solution is available so that the velocity can be resolved in an earth-fixed frame [10]. The estimation models we deal with belong to the TRN filter block in Figure 6, taking relative movement information from the INS as \n\n\nu\nk\n\n\n.
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Figure 6.
Conventional TRN structure.
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Typical TRN systems utilize measurements of the terrain elevation underneath an aircraft. The terrain elevation measurement is modeled as:
where \n\nh\n\n\nx\nk\n\n\n\n denotes terrain elevation from the DEM evaluated at the horizontal position, \n\n\nx\nk\n\n\n, and \n\n\nυ\nk\n\n\n denotes the additive Gaussian measurement noise. The elevation measurement is obtained by subtracting the ground clearance measurement from a radar altimeter, \n\n\nh\nr\n\n\n, from the barometric altimeter measurement, \n\n\nh\nb\n\n\n. \n\n\nυ\nk\n\n\n contains errors of the radar altimeter, barometric altimeter, and DEM. The ground clearance and the barometric altitude correspond to the above ground level (AGL) height and the mean sea level (MSL) height, respectively. The relationship between the measurements is depicted in Figure 7. Note that the terrain elevation that comprises the measurement model in (34) is highly nonlinear.
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Figure 7.
Relationship between measurements in TRN.
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The process model in (33) and the measurement model in (34) can be linearized as:
where \n\nD\n\nϕ\nλ\n\n\n denotes the terrain elevation from the DEM on the horizontal position \n\n\n\nϕ\nλ\n\nT\n\n\n.
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The DEMs are essentially provided as matrices containing grid-spaced elevation data. For obtaining finer-resolution data, interpolation techniques are often used to estimate the unknown value in between the grid points. One of the simplest methods is linear interpolation. Linear interpolation is quick and easy, but it is not very precise. A generalization of linear interpolation is polynomial interpolation. Polynomial interpolation expresses data points as higher degree polynomial. Polynomial interpolation overcomes most of the problems of linear interpolation. However, calculating the interpolating polynomial is computationally expensive. Furthermore, the shape of the resulting curve may be different to what is known about the data, especially for very high or low values of the independent variable. These disadvantages can be resolved by using spline interpolation. Spline interpolation uses low-degree polynomials in each of the data intervals and let the polynomial pieces fit smoothly together. That is, its second derivative is zero at the grid points (see [11] for more details). Classical approach to use polynomials of degree 3 is called cubic spline. Because the elevation data are contained in a two-dimensional array, bilinear or bicubic interpolation are generally used. Interpolation for two-dimensional gridded data can be realized by interp2 function in MATLAB. Cubic spline interpolation is used in this example.
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The DEM we are using in this example has a \n\n100\n×\n100\n\n grid with a resolution of 30. The profile of the DEM can be depicted as Figure 8. The figure represents contours of the terrain where brighter color denotes regions with higher altitude. The point (20, 10) in the grid corresponds to the position \n\n\n\n600\n300\n\nT\n\n\n in the navigation frame.
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Figure 8.
Contour representation of terrain profile.
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An aircraft, initially located at \n\n\nx\n0\n\n=\n\n\n400\n400\n\nT\n\n\n, is moving by 20 every time step in x direction. The aircraft is equipped with a radar altimter and a barometric altimter, which are used for obtaining the terrain elevation. This measured terrain elevation is compared to the DEM to estimate the vehicle’s position.
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The process noise \n\n\nw\n\nk\n−\n1\n\n\n\n is a zero-mean Gaussian noise with the standard deviation of \n\n\n\n0.5\n0.5\n\nT\n\n\n. The radar altimeter is corrupted with a zero-mean Gaussian noise with the standard deviation of 3. The matrices \n\nQ\n\n and \n\nR\n\n are following the real statistics of the noises as:
Let us consider \n\nN\n=\n100\n\n time steps (\n\nk\n=\n1\n,\n2\n,\n3\n,\n…\n,\nN\n)\n\n with \n\nΔt\n=\n1\n\n. \n\nM\n=\n100\n\n Monte-Carlo runs were conducted with the following initial guesses:
The above equation means the error of the initial guess for the target state is randomly sampled from a Gaussian distribution with a standard deviation of \n\n\n50\n50\n\n\n.
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The time history of RMSE of the navigation is shown in Figure 9. One can observe the RMSE converges relatively slower than other examples. Because the TRN estimates 2D position by using the height measurements, it often lacks information on the vehicle state. Moreover, note that the extended Kalman filter linearizes the terrain model and deals with the slope that is effective locally. If the gradient of the terrain is zero, the measurement matrix \n\nH\n\n has zero-diagonal terms that has zero effect on the state correction. In this case, the measurement is called ambiguous [12] and this ambiguous measurement often causes filter degradation and divergence even in nonlinear filtering techniques. With highly nonlinear terrain models, TRN systems have recently been constructed with other nonlinear filtering methods such as point-mass filters and particle filters, rather than extended Kalman filters.
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Figure 9.
Time history of RMSE.
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Source code of MATLAB implementation for this example can be found in [5]. It is recommended for the readers to change the parameters and aircraft trajectory by yourself and see what happens.
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4. Conclusion
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In this chapter, we introduced the Kalman filter and extended Kalman filter algorithms. INS/GNSS navigation, target tracking, and terrain-referenced navigation were provided as examples for reader’s better understanding of practical usage of the Kalman filters. This chapter will become a prerequisite for other contents in the book for those who do not have a strong background in estimation theory.
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\n\n',keywords:"Kalman filter, extended Kalman filter, INS/GNSS navigation, target tracking, terrain-referenced navigation",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/63164.pdf",chapterXML:"https://mts.intechopen.com/source/xml/63164.xml",downloadPdfUrl:"/chapter/pdf-download/63164",previewPdfUrl:"/chapter/pdf-preview/63164",totalDownloads:10987,totalViews:1564,totalCrossrefCites:25,dateSubmitted:"April 26th 2018",dateReviewed:"July 30th 2018",datePrePublished:"November 5th 2018",datePublished:"May 22nd 2019",dateFinished:"August 22nd 2018",readingETA:"0",abstract:"We provide a tutorial-like description of Kalman filter and extended Kalman filter. This chapter aims for those who need to teach Kalman filters to others, or for those who do not have a strong background in estimation theory. Following a problem definition of state estimation, filtering algorithms will be presented with supporting examples to help readers easily grasp how the Kalman filters work. Implementations on INS/GNSS navigation, target tracking, and terrain-referenced navigation (TRN) are given. In each example, we discuss how to choose, implement, tune, and modify the algorithms for real world practices. Source codes for implementing the examples are also provided. In conclusion, this chapter will become a prerequisite for other contents in the book.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/63164",risUrl:"/chapter/ris/63164",signatures:"Youngjoo Kim and Hyochoong Bang",book:{id:"7466",type:"book",title:"Introduction and Implementations of the Kalman Filter",subtitle:null,fullTitle:"Introduction and Implementations of the Kalman Filter",slug:"introduction-and-implementations-of-the-kalman-filter",publishedDate:"May 22nd 2019",bookSignature:"Felix Govaers",coverURL:"https://cdn.intechopen.com/books/images_new/7466.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-537-1",printIsbn:"978-1-83880-536-4",pdfIsbn:"978-1-83880-739-9",isAvailableForWebshopOrdering:!0,editors:[{id:"209490",title:"Dr.",name:"Felix",middleName:null,surname:"Govaers",slug:"felix-govaers",fullName:"Felix Govaers"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. 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IEEE Transactions on Aerospace and Electronic Systems. 2003;39(4):1333-1364\n'},{id:"B3",body:'Rajamani MR, Rawlings JB. Estimation of the disturbance structure from data using semidefinite programming and optimal weighting. Automatica. 2009;45(1):142-148\n'},{id:"B4",body:'Matisko P, Havlena V. Noise covariance estimation for Kalman filter tuning using Bayesian approach and Monte Carlo. International Journal of Adaptive Control and Signal Processing. 2013;27(11):957-973\n'},{id:"B5",body:'Introduction to Kalman Filter and Its Applications. 2018. Available from: https://uk.mathworks.com/matlabcentral/fileexchange/68262-introduction-to-kalman-filter-and-its-applications\n\n'},{id:"B6",body:'Kim Y, Jung W, Bang H. Real-time path planning to dispatch a mobile sensor into an operational area. Information Fusion. 2019;45:27-37\n'},{id:"B7",body:'Kim Y, Bang H. Vision-based navigation for unmanned aircraft using ground feature points and terrain elevation data. Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering. 2018;232(7):1334-1346\n'},{id:"B8",body:'Vadlamani AK, de Haag MU. Dual airborne laser scanners aided inertial for improved autonomous navigation. IEEE Transactions on Aerospace and Electronic Systems. 2009;45(4):1483-1498\n'},{id:"B9",body:'Kim Y, Park J, Bang H. Terrain referenced navigation using an interferometric radar altimeter, NAVIGATION. Journal of the Institute of Navigation. 2018;65(2):157-167\n'},{id:"B10",body:'Rogers RM. Applied mathematics in integrated navigation systems. American Institute of Aeronautics and Astronautics. 2007\n'},{id:"B11",body:'Interpolation. Available from: https://en.wikipedia.org/w/index.php?title=Interpolation&oldid=765887238\n\n'},{id:"B12",body:'Kim Y, Hong K, Bang H. Utilizing out-of-sequence measurement for ambiguous update in particle filtering. IEEE Transactions on Aerospace and Electronic Systems. 2018;54(1):493-501\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Youngjoo Kim",address:"yjkim@ascl.kaist.ac.kr",affiliation:'
Korea Advanced Institute of Science and Technology, Daejeon, South Korea
Korea Advanced Institute of Science and Technology, Daejeon, South Korea
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All IntechOpen published chapters and articles are available OPEN ACCESS and can be read without the requirement for registration of any kind, immediately upon publication, without any barrier.
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Registration is requested only to download the PDF of the chapter/article. There are no subscription fees and there is no charge to user groups.
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IntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
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It is an oldest, most efficient, and easiest method to apply any surface without modifying the intrinsic properties of materials. Moreover, the initial phase of fire always occurs on the surface by ignition, and hence, it is important to concentrate on the surface protection of a material. Being an organic nature of conventional surface coating will burn easily and generate smoke and toxic fumes, which may not be suitable for application where fire protection or fire prevention is required. Reaction-to-fire and/or resistance-to-fire are to be considered for assessing both flammable and non-flammable material by using fire retardant and fire resistant or fire protective coatings. The degree of fire retardation mainly depends on the coating thickness, substrates, and efficiency of formulations. This chapter explains briefly the fire retardation of wood by using fire retardant coatings.",book:{id:"5827",slug:"new-technologies-in-protective-coatings",title:"New Technologies in Protective Coatings",fullTitle:"New Technologies in Protective Coatings"},signatures:"Thirumal Mariappan",authors:[{id:"198114",title:"Dr.",name:"Thirumal",middleName:null,surname:"Mariappan",slug:"thirumal-mariappan",fullName:"Thirumal Mariappan"}]},{id:"75967",title:"Recent Advances in Ceramic Materials for Dentistry",slug:"recent-advances-in-ceramic-materials-for-dentistry",totalDownloads:774,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Dental ceramics constitute a heterogeneous group of materials with desirable optical and mechanical proprieties combined with chemical stability. They are inorganic non-metallic materials used in several applications. These materials are biocompatible to tissue, highly esthetic, with satisfying resistance to tensile and shear stress. Over the past years, several developments in new ceramic materials in dental restoration were achieved, including processing techniques and high mechanical properties. Thus, concepts on the structure and strengthening mechanisms of dental ceramic materials are also discussed. The dental practitioner requires best knowledge concerning indications, limitations, and correct use of started materials. The purpose of this book chapter is to overview advances in new ceramic materials and processes, which are used in dentistry. The properties of these materials are also discussed.",book:{id:"9894",slug:"advanced-ceramic-materials",title:"Advanced Ceramic Materials",fullTitle:"Advanced Ceramic Materials"},signatures:"Mohsen Mhadhbi, Faïçal Khlissa and Chaker Bouzidi",authors:[{id:"228366",title:"Dr.",name:"Mohsen",middleName:null,surname:"Mhadhbi",slug:"mohsen-mhadhbi",fullName:"Mohsen Mhadhbi"},{id:"324375",title:"Dr.",name:"Faïçal",middleName:null,surname:"Khlissa",slug:"faical-khlissa",fullName:"Faïçal Khlissa"},{id:"324535",title:"Dr.",name:"Chaker",middleName:null,surname:"Bouzidi",slug:"chaker-bouzidi",fullName:"Chaker Bouzidi"}]},{id:"66615",title:"Survey of Bauxite Resources, Alumina Industry and the Prospects of the Production of Geopolymer Composites from the Resulting by-product",slug:"survey-of-bauxite-resources-alumina-industry-and-the-prospects-of-the-production-of-geopolymer-compo",totalDownloads:1199,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Guinea is endowed with huge mineral resources. Several geological surveys have identified bauxite, iron, gold, diamond, and several metal ores. Because of the diversity and the magnitude of its resources, the country is referred to as a geological scandal. Nowadays the aluminum industry is still at the quarrying stage of bauxite, the main raw material that is converted into alumina and further to aluminum. Approximately 35–40% of the processed bauxite ore goes into the waste as alkaline red mud RM slurry which consists of 15–40% solids. RM and other industrial wastes material such as fly ash FA, rice husk ash RHA, that poses environmental hazards can be mixed to make them apt for usage in engineering applications. Geopolymers GP represent a new class of materials consisting of Al2O3▬SiO2-based material suitable for several engineering application. The present chapter presents the bauxitic potential of Guinea, the subsequent developing alumina industry. It reviews the application of RM for the production of geopolymer materials in the perspective of the valorization of the huge bauxite potential of Guinea.",book:{id:"8612",slug:"geopolymers-and-other-geosynthetics",title:"Geopolymers and Other Geosynthetics",fullTitle:"Geopolymers and Other Geosynthetics"},signatures:"Sékou Traoré, A. Diarra, O. Kourouma and D.L. Traoré",authors:[{id:"266484",title:"Prof.",name:"Sekou",middleName:null,surname:"Traore",slug:"sekou-traore",fullName:"Sekou Traore"},{id:"272379",title:"Dr.",name:"Doussou L.",middleName:null,surname:"Traoré",slug:"doussou-l.-traore",fullName:"Doussou L. Traoré"}]},{id:"59550",title:"Introductory Chapter: A Brief Introduction to Porous Ceramic",slug:"introductory-chapter-a-brief-introduction-to-porous-ceramic",totalDownloads:1842,totalCrossrefCites:6,totalDimensionsCites:15,abstract:null,book:{id:"6084",slug:"recent-advances-in-porous-ceramics",title:"Recent Advances in Porous Ceramics",fullTitle:"Recent Advances in Porous Ceramics"},signatures:"Uday M. Basheer Al-Naib",authors:[{id:"182041",title:null,name:"Uday",middleName:"M.",surname:"Basheer",slug:"uday-basheer",fullName:"Uday Basheer"}]}],onlineFirstChaptersFilter:{topicId:"155",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. 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Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,annualVolume:11978,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. 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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/73411",hash:"",query:{},params:{id:"73411"},fullPath:"/chapters/73411",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()