\r\n\tWe need such information of the environmental indicators day and night, from the crowded cities and the most remote locations. Therefore the study, development, and application of automated sensing systems have been booming during the last decades and the progress in this field is really fast.
\r\n
\r\n\tThe current book intends to provide the reader with the most recent trends in the development of sensing technologies for environmental control and monitoring, application of these novel technologies for the detection and monitoring of different environmental indicators, but also identification of hazardous chemical compounds and pathogens, and to introduce various aspects of using the online sensing data for decision-making in different fields of social life. \r\n\t
",isbn:"978-1-80355-838-7",printIsbn:"978-1-80355-837-0",pdfIsbn:"978-1-80355-839-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"cf1ee76443e393bc7597723c3ee3e26f",bookSignature:"Dr. Toonika Rinken and Dr. Kairi Kivirand",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11664.jpg",keywords:"Chemical Sensors, Biosensors, Detection Principles, Environment Quality, Residues, Hazardous Compounds, Pathogens, Natural Toxins, Controlling Climate Change, Rapid Warning Systems, Penalties for Pollution, Identification of Contamination",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 2nd 2022",dateEndSecondStepPublish:"May 4th 2022",dateEndThirdStepPublish:"July 3rd 2022",dateEndFourthStepPublish:"September 21st 2022",dateEndFifthStepPublish:"November 20th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Long-time lecturer of environmental chemodynamics and researcher in biosensing technologies, inventor of pioneering technical solutions, and holder of several registered patents.",coeditorOneBiosketch:"Researcher at the University of Tartu and expert in the application of liquid chromatography systems for the extraction and purification of bioactive compounds.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"24687",title:"Dr.",name:"Toonika",middleName:null,surname:"Rinken",slug:"toonika-rinken",fullName:"Toonika Rinken",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhRjQAK/Profile_Picture_1636637493542",biography:"Toonika Rinken is an associate professor in environmental chemistry and is leading a biosensor development lab at the Institute of Chemistry in the University of Tartu, Estonia. She received her PhD degree in chemistry in 2000 in the same university for the modeling and calibration studies of biosensors and has passed professional self-improvement in Uppsala (Sweden) and Gröningen (the Netherlands). Dr. Rinken's research activities are focused on the studies and development of biosensing systems for automatic monitoring along with testing and application of biosensor based analytical systems.",institutionString:"University of Tartu",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"University of Tartu",institutionURL:null,country:{name:"Estonia"}}}],coeditorOne:{id:"174179",title:"Dr.",name:"Kairi",middleName:null,surname:"Kivirand",slug:"kairi-kivirand",fullName:"Kairi Kivirand",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGZyQAO/Profile_Picture_1636637741285",biography:"Dr. Kairi Kivirand is a researcher at the University of Tartu. She received a Ph.D. in environmental chemistry in 2011 for her studies on biosensors for biogenic amines. Her research activities are focused on the purification, identification and characterization of bioactive molecules and on the design and development of biosensing systems for variety range of applications. She is an expert in the application of liquid chromatography systems for the extraction and purification of bioactive compounds. 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\n
1. Introduction
\n
With the development of technologies such as industrial robots and computer image processing, a series of research and experiments on intelligent picking robots have been carried out in Japan and other related countries, such as tomato, apple, and grape picking robots [1]. Research on picking robots has focused on two parts: the first is a hardware device that can achieve rapid picking, that is, how to design a stable, efficient, and adaptable mechanical and visual sensing system, and the second is to design intelligent software for continuous operations, that is, to accurately identify, distinguish, and locate targets and to solve the problem of task planning and task scheduling during continuous picking operations.
\n
In the research field of picking robots, Kondo et al. [2] designed a tomato picking robot using a 7-degree-of-freedom manipulator. It used fingers and pneumatic nozzles in conjunction with a color camera to complete the picking operation. The experiment achieved a picking success rate of about 70% [3]. Tanigaki et al. [4] developed a cherry picking robot using a four-degree-of-freedom manipulator and a specially designed end effector with suction and shear functions. The visual part uses a light emitter, a photodetector, and a scanning device. The fruit was picked in 14 s, and the success rate was about 84%. The CROPS plan completed in 2014 was jointly completed by many European countries and units and aims to develop a modular picking robot system for different mission scenarios. The greenhouse bell pepper picking robot platform completed in the experiment in the Netherlands [5] used a 9-degree-of-freedom manipulator, two color CCD cameras and a depth-measuring camera, and its end effector was also equipped with a small camera to complete the picking with higher accuracy. Taqi et al. [6] have developed small household cherry tomato picking robots that can achieve very accurate picking tasks in specific environments.
\n
The continuous operation of the picking robot can make intelligent decisions on multi-task under multi-objective scenarios and plan the operation according to the picking needs. The research goal is that the picking robot system can intelligently select and pick fruits that meet the picking conditions, thereby greatly improving the degree of automation of the picking process and improving the quality of the harvested fruits. Because the picking robot is still in the laboratory research stage, the research on continuous operation is also very limited, and it is basically in its infancy. Japan’s Nagata et al. [7] used the shape to judge and classify strawberry quality. The accuracy in the experiment is acceptable, but the speed is much slower than artificial. Zhao et al. [8] investigated the visual recognition of apple maturity, using multi-spectral laser beams to complete fruit identification and positioning and ripeness judgment. Guo [9] and others judged strawberry maturity based on HIS color space algorithm. In the field test, the accuracy of the goal of picking fruits with maturity of 80% or more was more than 90%. Wang [10] and Ling et al. [11] carried out research on selective harvest information acquisition and path planning of tomato picking robots. Multi-sensor information fusion method was used for tomato quality detection and classification and selective picking decision. The appearance maturity of the fruit is detected by the H-means in the computer image, the fruits are classified in real time according to the agricultural industry standards, and the selective harvesting decision is made through the progressive identification of feature information and the fusion decision. At harvest time, path planning is performed on multiple targets through an optimization algorithm and then boxed by level.
\n
This chapter mainly focuses on developing an intelligent software system for the continuous operation of the dual-arm picking robot in a plant factory. Typically, the semi-structure environment of the greenhouse poses challenges for autonomous operations of the robot, and the complex tasks mainly include identification and positioning under variable light conditions, selective picking in multi-cluster growth environment, and complex multi-task programming. For the difficulty of developing the software system, a hierarchical modular software system framework is designed. Moreover, a scheduling method of functional modules is designed based on the idea of finite state machine for the complex multi-task planning problem of tomato continuous picking process. The task scheduling design based on the Finite State Machine (FSM) reduces the difficulty of development work and improves the efficiency of development.
\n
This chapter is organized as follows: Section 2 briefly describes the hardware structure of a dual-arm robot, and Section 3 presents the software framework with the highlights of deploying SMACH- and ViSP-based nodes in a ROS development environment. The experimental results are also included at the end of Section 3.
\n
\n
\n
2. Hardware design of a dual-arm robot
\n
The semi-structured operating environment in the plant factory is relatively complicated, such as the occlusion of fruit branches and leaves, the challenging grasping shape of the fruit, the changing light, and the variety of tasks, which requires to consider the multi-tasking ability of the robot when designing the hardware of the picking robot. At the same time, the complexity of the picking environment requires that the execution of the robot be robust to the environment in which the target is located, only in this way can it pick fruits in different states. Based on the above two design goals, we designed a dual-arm picking robot to simulate human picking operations.
\n
\n
2.1 Design of dual-arm robot body
\n
The mechanical structure of the robot body mimics human arms, and the left and right arms each have three joints: a vertical lift joint, a boom rotation joint, and a forearm rotation joint. The vertical lifting joint is driven by a servo motor to drive the roller screw. The actual effective stroke is about 300 mm. The big and small arm joints are driven by a servo motor connected to a harmonic reducer. There is a waist joint between the body and the base, which can provide 360° rotary motion. The single-arm movement of the robot is similar to that of the SCARA robot. The vertical positioning is achieved by the lifting joint, and the rotation of the large and small arms realizes the positioning in the plane. There are three degrees of freedom in motion. Each of the left and right forearms is designed with a mounting flange surface, and end effectors can be installed as required. The dual-arm robot base is installed on a mobile cart and is transported along the track to different picking points for picking operations.
\n
Due to the limitation of the freedom of the robot body, for complex tomato picking environments, it is not enough to rely only on the freedom of the arms, so we can use the design of the end effector to increase the freedom of our robot and enable the robot to flexibly complete the picking operation. We designed a shearing end effector on the cutting hand of the dual-arm robot and designed a suction-type end sleeve on the auxiliary hand to fix the target tomato and assist the hand in picking (Figure 1).
\n
Figure 1.
The structure of the robot body.
\n
\n
\n
2.2 Dual-arm robot coordinate system
\n
As shown in Figure 2, the world coordinate system \n\n\n\nx\nw\n\n\ny\nw\n\n\nz\nw\n\n\n\n of the dual-arm robot is built on the waist and coincides with the waist joint coordinate system. The left and right arm coordinate systems \n\n\n\nx\nl\n\n\ny\nl\n\n\nz\nl\n\n\n\n and \n\n\n\nx\nr\n\n\ny\nr\n\n\nz\nr\n\n\n\n use the right-hand principle, and the span direction at the zero position of the x axis is different from the x axis of the world coordinate system by +45° and −45°. The z-axis direction is vertically upward and is at the zero position at the lowest point. The x–y plane is parallel to the world coordinate system x–y plane. The binocular camera coordinate system is established at the intersection of the right-eye visual axis and the camera lens. The coordinate system adopted by the bumblebee2 camera is the left-hand principle. In order to be compatible with the entire system, the y-axis direction is reversed.
\n
Figure 2.
Robot coordinate system.
\n
We use the tf function package [12] provided by ROS to maintain the transformation relationship between coordinate systems. After the robot model is built according to urdf, the system will automatically broadcast the transformation relationships between all the coordinate systems. The picking robot coordinate system is shown in Figure 3.
\n
Figure 3.
The picking robot tf coordinate system under Rivz.
\n
Based on the above coordinate system, using the rosrun tf view_frames command, we can view the tf tree of the dual-arm picking robot, as shown in Figure 4.
\n
Figure 4.
The tf tree of robot.
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\n
\n
2.3 Communication architecture of the dual-arm picking robot
\n
The communication architecture of the dual-arm picking robot is shown in Figure 5. The motor driver is a Gold series motor driver produced by Elmo and is equipped with the same series of multi-axis controllers. The manufacturer has provided a complete motor driver to multi-axis controller communication protocol and communication protocol implementation and does not require customers to conduct secondary development. The multi-axis controller uses Modbus TCP communication as the communication between the lower computer and the industrial computer. It is connected to it through an Ethernet cable.
\n
Figure 5.
Picking robot communication architecture.
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\n
\n
\n
3. Software frame design
\n
In the process of programming, we generally manually divide the tasks of the robot. Once the tasks are effectively divided, we can stack the tasks with the smallest functional components, so the difficulty of task division is how to use human prior knowledge to divide the minimum granularity of robot skills, which is a learning process. At the same time, how to easily and effectively combine the divided components is also an important part of completing the task simulation.
\n
The system architecture describes the functional structure of the subdivision and the topological relationship between them and a series of specifications that need to be set for subsequent development. The basic requirements of software engineering include modularity, code reuse, and function sharing. Using a common framework is helpful for decomposing development tasks and code migration. Robot software also follows the general rules of software engineering. Architecture is how you break up the robot’s functions and organize your code. A clear architecture that matches the project directly determines your development efficiency and even the success or failure of the final function. There are two main approaches to robot system architecture: SPA architecture and behavior-based architecture.
\n
\n
3.1 SPA
\n
The software system architecture is “Sense Plan Act”(SPA), as shown in Figure 6. The robot maps the external environment space through sensors and uses a certain modeling method to structure and model the perception information and then analyzes the model to plan the robot’s actions. Finally, the action instructions are executed in the environment to achieve a complete interactive process.
\n
Figure 6.
SPA work pattern.
\n
The typical software architecture in a SPA robot system is a three-layer architecture: the perception layer, the planning layer, and the motion control layer, as shown in Figure 7. The perception layer receives and processes the sensor data, the planning layer plans the motion trajectory, and the motion control layer ensures the accurate execution of the movement. The SPA robot software system architecture pays more attention to the perception and modeling of the world because this is the basis for the accuracy of subsequent planning and movement.
\n
Figure 7.
SPA layered design.
\n
\n
\n
3.2 Behavior-based architecture
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The behavior-based software system architecture is a top-down software design. The small functions of each robot are packaged into individual small modules. All functional modules can be executed in parallel without prioritization. A robot task can be understood as an organic composition of functional modules (Figure 8).
\n
Figure 8.
Action-based software system architecture.
\n
To a certain extent, all robot actions are responses to stimuli (inputs). This stress mode avoids the thinking logic in the SPA architecture and facilitates the rapid action response. In order to achieve the task, we can design a control scheme to change the stress level of the action. Therefore, we need a global controller to coordinate the choice of actions in order to achieve our intended purpose. The behavior-based software design framework has good flexibility, but it increases the difficulty of control. When multiple actions can affect the output, problems are easy to occur.
\n
Therefore, combined with the SPA software architecture and behavior-based software architecture, we design a software framework that combines the advantages of both architectures for continuous operation of a dual-arm picking robot. Its characteristics are as follows:
Hierarchical modular design: The software architecture absorbs the advantages of the SPA architecture and also adopts a hierarchical design. The layered design is mainly logical, which makes it easier for users to understand the working mode of the robot. At the same time, it also absorbs the advantages of behavior-based architecture, that is, functional modularity. Based on the analysis and understanding of the robot’s internal architecture, we divide the functions of the robot into seven modules, each of which is functionally independent of each other. Combining the above two is a hierarchical modular design, which divides the functional modules into a specific layer according to the attributes of the functions, thus strengthening the logic of the system.
Finite state machine control: In order to solve the shortcomings of behavior-based architecture, we have designed a task planning module based on finite state machines, which is used to schedule and control the execution order of each functional module to complete a specific task.
\n\n
\n
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3.3 Hierarchical modular design
\n
Layering is an important concept in software design. The division of layers provides a framework for business decomposition and simplifies many thinking processes. Considering the design characteristics of the software system and the functional features of the robot, the entire software architecture can be divided into four layers: presentation layer, application layer, sense layer, and data layer. The hierarchical modular design architecture is shown in Figure 9.
Presentation layer: Presentation layer has more business logic requirements. We designed the presentation layer based on the QT architecture. The entire presentation layer includes several main components as shown in Figure 10: the RVIZ module displays the model of the robot and other visual information; the image module displays the video image information collected by the current robot; the node module monitors all current node information; and the DashBoard module provides users with a function module for manually operating the robot; shell module provides command line functions; console module displays all log information executed by the system; reconfigure module provides users with a convenient tool for changing model parameters; and diagnostic module provides real-time robot monitoring information.
Application layer: Application layer focuses on the task execution of a single robot. It is separated from the implementation of specific functions and uses a combination of function modules to coordinate a task.
Sense layer: Sense layer is responsible for the interaction between the software system and the hardware. There are both a visual module responsible for environmental perception and a motion module responsible for the motion control of the upper and lower computers. Sense layer is a description of the robot’s capabilities.
Data layer: Data layer serves the data generated by the system. Part of the data generated by the system is stored in a local database for real-time decision making of the system. One part is uploaded to the server through the network and is fused with data from other robots and other time dimensions to plan the continuous operation of the robot.
\n\n
Figure 9.
Layered modular architecture design.
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Figure 10.
Presentation layer.
\n
The criteria for the division of functional modules are to reduce coupling, relatively independent functions, and high code repeatability. According to the robot’s task module, the software system can be divided into motion (motion_pkg), control (control_pkg), vision (vision_pkg), visualization (visualization_pkg), collaboration (coorperation_pkg), database (database_pkg), and network (network_pkg). Each function module is represented as a function package at the file system layer. There can be multiple nodes in a package, and different nodes can be written in different programming languages.
\n
\n
\n
3.4 Cooperative control of dual-arm picking based on FSM
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\n
3.4.1 SMACH
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Finite state machine (FSM) is a mathematical model of computational science. The objects it represents can be in a limited number of states at any one time. When an external input occurs, the system responds to the external input, and the FSM can conditionally transition from one state to another. This process is called an action. In computer science, finite state machines are widely used for modeling application behavior, hardware circuit system design, software engineering, compilers, network protocols, and computation and language research. FSM can be defined by the present state, condition, action, and substate. The specific interpretation is as follows:
Present state: The current state.
Condition: The premise of triggering an action can also be considered as an event. When a condition is filled, an action will be triggered.
Action: The operation performed when the conditions are met and can be regarded as a unit of calculation or transaction processing. After the action is completed, it can be transferred to a new state, it can still be in the original state, or it can be terminated.
Substate: The state after the present state transition. When different actions occur and different conditions are generated, a state may transition to a different substate. Once the transition is completed, it becomes the present state.
\n\n
As shown in Figure 11, a task can be represented by a state transition diagram.
\n
Figure 11.
Finite state machine.
\n
SMACH [13, 14, 15], which refers to “State Machine,” is a powerful and scalable Python-based library for hierarchical state machines. The SMACH library does not depend on ROS and can be used in any Python project. The executive_smach stack, however, provides very nice integration with ROS, including smooth actionlib integration and a powerful SMACH viewer to visualize and introspect state machines. The SMACH core library is lightweight and mainly provides two interfaces: State and Container.
\n
State: The state represents the state being executed. Each state has some potential outputs. The State class outputs the result by implementing the blocking function execute().
\n
Container: The container is a collection of one or more states that enforces some strategy. The simplest container is a State machine. A SMACH state machine can be viewed as a state flow graph, where each node is an execution state (the robot is performing a certain action), and the edges connecting the nodes represent transitions between states. The State machine itself can also be regarded as a state and has its own output, so they can be combined in layers to complete a complex task.
SMACH uses action files to define communication protocols between different states. The structure of the action file is simple and clear, as shown in Figure 13. Three data definition areas are separated by three underscores. The first area defines the message format of the request, and the middle area defines the returned result (result message format, the bottom area defines the intermediate information feedback) message format. Each area can contain multiple data type, and the system will automatically compile the action file into three message files during the compilation process, so the message format for communication between states is actually the message format provided by ROS.
\n
Figure 13.
File format of action.
\n
SMACH provides a general state type to support invocation while providing a special state class SimpleActionState as a proxy for actionlib. During the construction of the SimpleActionState object, the corresponding actionlib client is started by default. The user can define a goal in the constructor and create a callback function to process the data returned by the actionlib server.
\n
\n
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3.4.2 Hierarchical concurrent state machine design
\n
For the picking robot to perform a continuous picking task, we can use the state transition process to describe it. The detailed description of the state transition is as follows: first enter the startup state, start the picking robot platform, wait for the initialization of each component, and perform a startup self-test. If any component fails to initialize and is in a fault state, the startup fails, and then the system is placed in the error state, stopping working and the task ends.
\n
If the startup is successful, the platform moves into the state, the mobile platform moves to the first picking point, and data collection state and the tomato scanning state are started at the same time. The data collection state collects tomato information in the current status and uploads it to the database of the server; the tomato scan state checks whether there are tomatoes suitable for picking in the viewing area. If not, restart the platform moving state and move the robot to the next picking point; if so, first analyze all the tomato position information and pass the spatial attitude information of the first target tomato to the kinematics solution state according to the predetermined rules, and then program performs kinematics calculation and motion planning. If the tomato is unreachable, the information of the next target tomato is passed to the kinematics solution state, and so on until the last tomato is reached. If it is determined that the tomato is unreachable, the platform is moved to the next picking point. If it is judged that the tomato is reachable, the calculated right arm motion information is transmitted to the robot motion state, and this state sends the trajectory information of the right arm motion to the lower computer and simultaneously detects the joint motion position information during the execution of the lower computer. After the right arm moves to the target position, it enters the suction state. The system starts the suction device to fix the tomatoes and move them to a suitable position, which is convenient for the left arm to cut hands. The kinematics solution state is started again, and the left arm motion information is solved and transmitted to the robot motion state to control the left arm to move near the target. The start of the visual servoing state is close to the target tomato precisely, and the cutting state is started after the arrival, the pneumatic shear transposition of the left arm is started, and the tomato is cut. After completing a tomato pick, pick the next goal planned. Repeat until the last picking point.
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According to the task execution process and state transition process described above, the designed state transition diagram is shown in Figure 14.
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Figure 14.
Continuous picking status flow.
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In SMACH, we use SimpleActionState to directly simulate the server side of actionlib and define a state machine with 10 states to control the robot to complete a comprehensive picking job.
DO_START: start state.
DO_MOVEBASE: mobile platform mobile status.
DO_TOMATO_SCAN: tomato scanning status.
DO_SPATIAL_TEMPORAL: data collection status.
DO_KINEMATICS: state of kinematics solution.
DO_MOVE_ROBOT: left and right arm movement status.
DO_MOVE_ENDEFFECTOR: end effector status.
DO_ERROR: fault status.
DO_STOP: emergency stop status.
DO_VISUALSERVOING: visual servoing status.
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3.5 Major software node design
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Based on the software framework design and operation requirements of the dual-arm picking robot, based on the functional division of each part, a vision module, an eye-hand coordination module, and a task planning module are mainly designed and installed in the industrial computer. Each module further refines the functions and can be divided into functional nodes. Nodes are the minimum functional modules in ROS, which regard as the ultimate goal of the design.
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3.5.1 Vision module node
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In the dual-arm acquisition robot eye-hand system, the main component of the “eye” is the camera, including a binocular camera mounted on the robot’s head and a monocular camera mounted on the arm. Based on the ROS framework, we designed three nodes to complete the environment perception function: binocular camera image acquisition node (dual_eye_image_capture), monocular camera image acquisition node (single_eye_image_capture), and image processing node (image_processing). The actual recognition effect is shown in Figure 15. There are three valid tomatoes in the image. The system recognizes all tomatoes and marks the positions of the tomatoes in the picture that need to be picked first according to the rules.
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Figure 15.
Tomato identification interface.
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The binocular camera acquisition node uses the two original images collected by the left and right sensors of the Bumblebee2 camera to finally generate five images: left and right eye corrected color images, left and right eye corrected gray images, and 3D point clouds (Figure 16).
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Figure 16.
Five pictures generated by Bumblebee2 camera. 1. Gray image of left eye after correction. 2. Color image of left eye after correction. 3. Gray image of right eye after correction. 4. Color image of right eye after correction. 5. Point cloud image.
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The collection process of the binocular camera is shown in Figure 17. The camera’s original data are read, and the data are packaged into a Bell template image; then, three color information is extracted from the Bell template image and assembled into the original color image. The eye image data are used to obtain corrected left and right eye color images and grayscale images. Next, the left and right eye images are used for stereo matching through the principle of triangulation to generate a 3D point cloud. In the end, all the five images generated were published, and the algorithm used in the image acquisition process was provided by the camera SDK.
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Figure 17.
Binocular image acquisition flow chart.
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Based on the above process, we designed the binocular collection program UML as shown in Figure 18.
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Figure 18.
Binocular acquisition node UML design.
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3.5.1.1 Monocular camera image acquisition node
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For monocular vision, we use a Daheng Mercury series industrial camera MER-500-7UC, which uses USB2.0 digital interface and provides free SDK and secondary development example source code under windows platform and Linux platform. We use the usb_camera package provided by ROS to collect monocular images, as shown in Figure 19.
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Figure 19.
Image captured by monocular camera.
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3.5.1.2 Image processing node
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The image processing node receives the collected planar image and point cloud image and provides different image processing function interfaces according to different business requirements. In the current task requirements, image processing nodes are required to complete the accurate two-dimensional recognition and accurate three-dimensional positioning of tomatoes. Therefore, the two-dimensional image dataset of the scene and the three-dimensional point cloud data are also required. Next, we introduce us from two directions. Image processing node design: first is the architecture design and functional flow of the image processing node as a functional interface, and the second is the specific implementation of related image processing algorithms.
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The entire software system is based on the C/S model architecture, using the actionlib function package provided by ROS, with the task planning node as the server, and requesting computing resources from the client of each functional unit. Image processing nodes are no exception. After receiving the image processing instructions and image data, the instructions are parsed to clarify the functional requirements, and then the required image data are extracted, input into the algorithm function for processing, and the results are finally returned to the server.
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The specific processing flow is shown in Figure 20. After initializing the node and actionlib server, start the service, wait for the goal sent by the client, and subscribe to the processing function. After receiving the instruction, analyze the source of the instruction. If the instruction originates from the spatial positioning of tomatoes, the processing steps are: first, use the tomato recognition algorithm based on image feature fusion to identify all tomatoes in the right eye image space of the binocular camera. If there are no tomatoes, return the results; if tomatoes are detected, plan the picking order. The rule is from bottom to top, left to right, and calculate the spatial position of the pick point, and finally return the result to the client. If the object recognition result triggers the harvesting task, the image collected by the monocular camera is used to extract the central image feature of the tomato.
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Figure 20.
Image processing node flow chart.
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According to the above process, the design program UML is shown in Figure 21.
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Figure 21.
Image processing node UML design.
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3.5.2 Eye-hand coordination module node
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3.5.2.1 Eye-hand collaboration process design
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Our solution uses an eye-in-hand vision servo solution to achieve eye-hand coordination, as shown in Figure 22. The picking robot obtains the image information of the target fruit through a monocular camera installed on the picking hand, extracts the position information of the tomato features in the two-dimensional image, and makes a difference from the expected position information. The difference is used as the input of the visual servo control algorithm and then calculate the control output in real time, that is, the speed vector of the end effector, and then integrate this speed vector with time to calculate the next point that needs to reach the target position. Cycle back and forth to get a trajectory that gradually approaches the target position. The eye-hand correspondence is converted into the amount of motion of the joint, and the end of the robot arm moves accordingly to approach the target. The implementation process is shown in Figure 23.
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Figure 22.
Visual servo program of eye-in-hand.
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Figure 23.
Eye-hand coordination process.
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3.5.2.2 ViSP
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ViSP [17] is an open source visual servo framework developed and maintained by the Lagadic team of the French National Institute of Information and Automation. It has the characteristics of hardware independence, scalability, and portability. In addition, ViSP also provides a complete library of basic functions, which can be combined with a variety of visual feature libraries; it also provides a simulation environment and interfaces with various hardware. Based on ViSP, we can complete functions such as visual tracking, fiducial marking, two-dimensional contour tracking, pose estimation, and so on. The goal of ViSP is to provide developers with a tool for rapid development of visual servo functions. The software framework of ViSP is shown in Figure 24. The entire framework is divided into three modules: one module provides vision models, vision servo control algorithms, and robot controller interfaces; the second module provides image processing algorithms, tracking algorithms and other machine vision algorithms; and the last module is a visualization module that provides a simulation and visual environment. All these features make ViSP very suitable for use as a core part of our module.
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Figure 24.
ViSP software architecture.
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3.5.2.3 Eye-hand collaboration module node design
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The complete flowchart of eye-hand coordination is shown in Figure 25. After the node is initialized, the system initializes and starts the ‘/visual_servo’ actionlib service and subscribes to execute() to wait for the client to be awakened. After receiving the service request, start the visual servo loop. In the loop, program request the feature position of the tomato image from the vision module and make a difference from the expected position. If the difference exceeds the threshold Δs (Δs=2mm), the program will obtain the camera parameters, initialize the control model, and call the ViSP library function vpServo() to calculate the control output speed vector. Then, program integrates the velocity vector with time (t = 1s), motion module controls robot to move to the output position, and requests the tomato image feature position from the vision module again, then makes a difference with the desired position, and loops back and forth until the target image feature. The difference between the position and the desired image feature position is less than the threshold Δs, the visual servo loop is ended, and our execution result is returned.
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Figure 25.
Eye-hand collaboration node flow chart.
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\nFigure 26 shows the design of the eye-hand coordination node class. There are mainly two classes. The VisualServoCycleNode class is responsible for the loop and interaction with other modules. The VisualServoControlNode module is responsible for controlling the operation of the algorithm.
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Figure 26.
Eye-hand coordination node class design UML diagram.
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3.5.3 Task planning module node
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The task planning module mainly completes the design and implementation of a layered concurrent state machine for one pick, as shown in Figure 27:
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Figure 27.
Task planning node flow chart.
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First we initialize the node, state machine, and user intermediate data, and then add the transformation relationship between the states of each state machine according to the state transition of the task design. Use the transition keyword to control the transition from the current state to the secondary state. At the same time, since each state is SimpleActionState, each state implements an actionlib client by default. You need to add an initialization function and a callback function callback() for each state. Start a state machine visualization service IntrospectionServer in the node, so that we can view the state transition diagram in SMACH_viewer and can monitor the state transition in real time. The data details of each state are shown in Figure 28.
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Figure 28.
FSM in SMACH_viewer.
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3.5.4 System node diagram
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\nFigure 29 shows that the running node diagram after all ROS nodes in the system is turned on. The node diagram is generated using the rqt_graph command. Each rectangular box represents a topic. The oval box represents a node, and the arrowed lines represent the subscription relationship between each other. Visualization of the node diagram makes the system architecture intuitive.
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Figure 29.
System function node diagram.
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Since most of the eye-hand coordination and motion control are concurrent, the fluency of multitasks is verified under two plant factories and three greenhouses with different fruit status and illumination variations. The experimental results show that if total number of targets within the visual field is not more than three, the average picking time is less than 35 s.
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4. Conclusion
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The contribution of this research mainly orients around the software engineering for manipulating the complex robot behavior. Although service robot leverages ROS for rapid development, classical tasks such as eye-hand coordination and continuous operation in an open scenario have not been systematically addressed. In this chapter, we advocate that if the complex robot behavior can be structured, then they can be modeled as Finite State Machines (FSM), and a “Sense Plan Act” (SPA) process can be implemented with a formal software architecture. Meanwhile, we demonstrate that ViSP and SMACH in ROS are beneficial frameworks for developing a dual-arm robot for autonomously harvesting the fruits in plant factory, which embodies the complexity of multi-task planning and scheduling in natural scenes. The experimental results show that the software engineering paradigm effectively improves the system reliability and scalability of the dual-arm harvesting robot.
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Acknowledgments
\n
This work was supported by the National Natural Science Foundation of China (No. 51775333) and the Scientific Research Program of Shanghai Science and Technology Commission (No. 18391901000).
\n
\n',keywords:"dual-arm robot, complex behavior, continuous operation, robot operating system (ROS), finite state machine",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/72250.pdf",chapterXML:"https://mts.intechopen.com/source/xml/72250.xml",downloadPdfUrl:"/chapter/pdf-download/72250",previewPdfUrl:"/chapter/pdf-preview/72250",totalDownloads:634,totalViews:0,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:50,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"December 2nd 2019",dateReviewed:"March 24th 2020",datePrePublished:"May 26th 2020",datePublished:"November 26th 2020",dateFinished:"May 20th 2020",readingETA:"0",abstract:"Service robot control faces challenges of dynamic environment and complex behavior, which mainly include eye-hand coordination and continuous operations. However, current programming scheme lacks the ability of managing such tasks. In this chapter, we propose a methodology of software development paradigm for the continuous operation of the dual-arm picking robot. First, a dual-arm robot is built for picking with the purpose of selectively harvesting in plant factory. Second, a hierarchical control software is framed by means of “Sense Plan Act” (SPA) paradigm. Third, based on the previous design, programming concept, and the ROS system, the sub-node programming of visual module, motion module, eye-hand coordination module, and task planning module are implemented with a state machine-based architecture. The experimental results show that if total number of targets within the visual field is not more than three, the average picking time is less than 35 s. The fluency of concurrent task management shows the feasibility of manipulating complex robot behavior for autonomous and continuous operations with the finite state machine model and task level architecture.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/72250",risUrl:"/chapter/ris/72250",book:{id:"9902",slug:"service-robotics"},signatures:"Chengliang Liu, Liang Gong and Wei Zhang",authors:[{id:"135507",title:"Prof.",name:"Chengliang",middleName:null,surname:"Liu",fullName:"Chengliang Liu",slug:"chengliang-liu",email:"chlliu@sjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"183226",title:"Dr.",name:"Liang",middleName:null,surname:"Gong",fullName:"Liang Gong",slug:"liang-gong",email:"gongliang_mi@sjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Shanghai Jiao Tong University",institutionURL:null,country:{name:"China"}}},{id:"318241",title:"Dr.",name:"Wei",middleName:null,surname:"Zhang",fullName:"Wei Zhang",slug:"wei-zhang",email:"zhang_wei@sjtu.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Shanghai Jiao Tong University",institutionURL:null,country:{name:"China"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Hardware design of a dual-arm robot",level:"1"},{id:"sec_2_2",title:"2.1 Design of dual-arm robot body",level:"2"},{id:"sec_3_2",title:"2.2 Dual-arm robot coordinate system",level:"2"},{id:"sec_4_2",title:"2.3 Communication architecture of the dual-arm picking robot",level:"2"},{id:"sec_6",title:"3. Software frame design",level:"1"},{id:"sec_6_2",title:"3.1 SPA",level:"2"},{id:"sec_7_2",title:"3.2 Behavior-based architecture",level:"2"},{id:"sec_8_2",title:"3.3 Hierarchical modular design",level:"2"},{id:"sec_9_2",title:"3.4 Cooperative control of dual-arm picking based on FSM",level:"2"},{id:"sec_9_3",title:"3.4.1 SMACH",level:"3"},{id:"sec_10_3",title:"3.4.2 Hierarchical concurrent state machine design",level:"3"},{id:"sec_12_2",title:"3.5 Major software node design",level:"2"},{id:"sec_12_3",title:"3.5.1 Vision module node",level:"3"},{id:"sec_12_4",title:"3.5.1.1 Monocular camera image acquisition node",level:"4"},{id:"sec_13_4",title:"3.5.1.2 Image processing node",level:"4"},{id:"sec_15_3",title:"3.5.2 Eye-hand coordination module node",level:"3"},{id:"sec_15_4",title:"3.5.2.1 Eye-hand collaboration process design",level:"4"},{id:"sec_16_4",title:"3.5.2.2 ViSP",level:"4"},{id:"sec_17_4",title:"3.5.2.3 Eye-hand collaboration module node design",level:"4"},{id:"sec_18_4",title:"3.5.3 Task planning module node",level:"4"},{id:"sec_19_4",title:"3.5.4 System node diagram",level:"4"},{id:"sec_23",title:"4. Conclusion",level:"1"},{id:"sec_24",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nSong J, Zhang T, Xu L, et al. Research actuality and prospect of picking robot for fruits and vegetables. Transactions of the Chinese Society for Agricultural Machinery. 2006;37:158-162\n'},{id:"B2",body:'\nKondo N et al. Fruit harvesting robots in Japan. Advances in Space Research. 1996;18:181-184. DOI: 10.1016/0273-1177(95)00806-P\n'},{id:"B3",body:'\nZhao Y, Wu C, Hu X, et al. Research progress and problems of agricultural robot. Transactions of the Chinese Society of Agricultural Engineering. 2003;19:20-24\n'},{id:"B4",body:'\nTanigaki K et al. Cherry-harvesting robot. Computers and Electronics in Agriculture. 2008;63:65-72. DOI: 10.1016/j.compag.2008.01.018\n'},{id:"B5",body:'\nHemming J et al. A robot for harvesting sweet-pepper in greenhouses. In: Proceedings International Conference of Agricultural Engineering. Zurich; 06-10 July 2014\n'},{id:"B6",body:'\nTaqi F et al. A cherry-tomato harvesting robot. In: 18th International Conference on Advanced Robotics (ICAR); 10-12 July 2017. Hong Kong. New York: IEEE; 2017. pp. 463-468\n'},{id:"B7",body:'\nNagata M et al. Studies on automatic sorting system for strawberry (part 3) development of sorting system using image processing. Journal of the Japanese Society of Agricultural Machinery. 1997;59:43-48\n'},{id:"B8",body:'\nZhaoxiang L, GANG L. Apple maturity discrimination and positioning system in an apple harvesting robot. New Zealand Journal of Agricultural Research. 2007;50:1103-1113. DOI: 10.1080/00288230709510392\n'},{id:"B9",body:'\nGuo F et al. Fruit detachment and classification method for strawberry harvesting robot. International Journal of Advanced Robotic Systems. 2008;5(1):41-48. DOI: 10.5772/5662\n'},{id:"B10",body:'\nWang X. Study on information acquisition and path planning of greenhouse tomato harvesting robot for selective harvesting operations [thesis]. Zhenjiang: Jiangsu University; 2012\n'},{id:"B11",body:'\nLing X, Zhao Y, Gong L, Liu C, Wang T. Dual-arm cooperation and implementing for robotic harvesting tomato using binocular vision. Robotics and Autonomous Systems. 2019;114(4):134-143\n'},{id:"B12",body:'\nFoote T. tf: The transform library. In: IEEE Conference on Technologies for Practical Robot Applications (TePRA); 22-23 April 2013. Woburn. New York: IEEE; 2013. pp. 1-6\n'},{id:"B13",body:'\nBohren J, Cousins S. The SMACH high-level executive [ROS news]. IEEE Robotics and Automation Magazine. 2010;17(4):18-20. DOI: 10.1109/MRA.2010.938836\n'},{id:"B14",body:'\nMcgann C et al. Model-Based, Hierarchical Control of a Mobile Manipulation Platform. Thessaloniki, Greece: ICAPS Workshop Planning and Plan Execution for Real-World Systems; 2009\n'},{id:"B15",body:'\nMeeussen W et al. Autonomous door opening and plugging in with a personal robot. In: IEEE International Conference on Robotics and Automation; 3-7 May 2010. Anchorage. New York: IEEE; 2010. pp. 729-736\n'},{id:"B16",body:'\nJoseph H. Getting Started with Smach [Internet]. 2018. Available from: https://wiki.ros.org/smach/Tutorials/Getting%20Started [Accessed: 21 March 2020]\n'},{id:"B17",body:'\nMarchand E et al. ViSP for visual servoing: A generic software platform with a wide class of robot control skills. IEEE Robotics and Automation Magazine. 2005;12(4):40-52. DOI: 10.1109/MRA.2005.1577023\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Chengliang Liu",address:null,affiliation:'
School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China
School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China
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1. Introduction
Antimicrobials are either synthetic or natural products (antibiotics) that are used in killing (bactericidal) or controlling the growth (bacteriostatic) of pathogenic microbes. Sometimes, antimicrobial and antibiotic are interchangeably used. Goats belong to species (caprine) and serve as the source of meat and milk [1], and the money realized from sales meet financial obligations of small- and large-scale goat farmers [2]. There are up to 800 million goats in the world [3]. The economic species of goats spread across the globe are not limited to Teddy, Kilis, Ardi, West African Dwarf, Black Bengal, Indian native, Murciano-Granadina, Angora, Red Sokoto, Boer and Nubian goats [4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. However, the diseases of goats include colibacillosis, salmonellosis, staphylococcosis and streptococcosis, among others [14]. Age, sex, dosage formulation, route of administration and dose of antimicrobials affect pharmacokinetics and pharmacodynamics of antimicrobials in goats [13]. For example, female West African dwarf goats are more sensitive to sulfadimidine than male West African dwarf goats [15]. There are also intraspecies differences in pharmacokinetic and pharmacodynamic parameters of domestic goat (Capra aegagrus hircus) such as West African dwarf, Pakistan, Shiba, Netherland dwarf, Nubian, Red cross-breed, Angora, Boer, LaMancha, Oberhasli, Toggenburg as well as wild goats, Capra aegagrus aegagrus (bezoar ibex), Capra aegagrus blythi (Sindh ibex), Oreamnos americanus (mountain goat), Capra aegagrus chialtanensis (Chiltan ibex), Capra aegagrus cretica (kri-kri), Capra aegagrus turcmenica (Turkmen wild goat) and Capra aegagrus pictus [15, 16, 17, 18, 19, 20]. However, Capra aegagrus hircus is the most popular domesticated from their wild progenitor, bezoar (Capra aegagrus) [21, 22]. Also, antimicrobials such as sulfonamides, trimethoprim-sulfamethoxazole, aminopenicillins, cephalosporins and quinolones could cause Stevens-Johnson syndrome in humans that eat goat meat which has the drugs residues [23] and tissue residues above threshold (2 ppm) could be found in the skeletal muscle, liver, kidney, milk, brain, intestine, heart and lung of goats which could portend threat to public health [13]. Although goats are domesticated 10,500 years ago, the genomic regions differentiating domestic goats from wild goats are associated to genes of the nervous system, immunity and productivity traits; 20 are common to Capra and Ovis [24] indicating the possible relevance of pharmacogenomics which is the study of how genes affect animal response to drugs. Because of unprecedented emergence of resistant bacteria, there is a fervent need to develop new veterinary drugs [25] using both in vitro and in vivo data that have been generated from basic, translational and clinical research. Solubility and permeability affect pharmacokinetics of oral formulations of antimicrobials in goats. The formulations are tablet, capsule, solution, suspension, etc.
2. Methodology
Intensive literature search was carried out with a view to identifying various chemical classes, dosage form, routes of administration, therapeutic doses, unique pharmacokinetic parameters such as elimination half-life, volume of distribution, bioavailability, concentration maximum, peak time, plasma concentration, minimum inhibitory concentration and spectrum of activities of various antimicrobials in various breeds of domestic and wild goats. Oral dose formulations of antimicrobials have been classified biopharmaceutically, and pharmacokinetic equations used for calculation of common pharmacokinetic parameters have been highlighted. Information on pharmacodynamic parameters, intraspecies and interspecies scaling, tissue residues, antimicrobial resistance, rehydration therapy and antimicrobial intoxication has been elucidated.
3. Results
Kinetic parameters of some antimicrobial drugs used in treatment of microbial infections in goats, goat-human extrapolated doses of some antimicrobials and half-life and tissue residues and withdrawal periods of some antimicrobials are presented in Tables 1–3, respectively.
Half-life, tissue residues and withdrawal period of some antimicrobials.
3.1 Biopharmaceutical classification of oral antimicrobials
This is a system of classifying antimicrobials based on aqueous solubility and intestinal permeability. The four major factors being considered in this classification system are dosage form, dissolution rate, solubility and permeability. Hence, antimicrobials are tested in vitro and classified into four classes:
Class 1: High solubility − high permeability
Class 2: Low solubility − high permeability
Class 3: High solubility − low permeability
Class 4: Low solubility − low permeability
All the classes of dissolution can occur in a pH range of 1–2, 4–5 and 6–8 [46]. Nevertheless, administration of highly toxic antimicrobials such as aminoglycosides (e.g. gentamicin) should be monitored since it damages the kidney.
Such drugsaresaid to have narrow therapeutic rangeNTR=Minimum toxic concentrationMTCMedian effective concentrationMEC
3.2 Pharmacokinetic equations of antimicrobials
Bioavailability, absorption half-life (T1/2α), mean absorption time (MAT), mean residence time (MRT), apparent volume of distribution (Vd), volume of distribution, steady state (Vdss), area under curve (AUC), area under the first moment curve (AUMC), peak time (Tmax), elimination half-life (T1/2β) and systemic clearance (Cl) are the pharmacokinetic parameters commonly determined in all species of animals and humans [7, 9, 47, 48, 49]. The most important of all these parameters are elimination half-life, volume of distribution and plasma concentration of the antimicrobials.
The pharmacokinetic process of antimicrobials in goats obeys first-order kinetic (Figures 1 and 2) which could be mono-exponential or bi-exponential. The exponential equation commonly used for determination of pharmacokinetic parameters is CP = Aeαt + Be−βt. Other equations are:
T1/2α=0.693×MATkaE1
MAT=1/kaE2
MRT=AUMCAUCE3
Vd=ClbβE4
AUC=DoseClE5
AUMC=MRT×AUCE6
T1/2β=0.693βE7
Clb=DoseAUCE8
Figure 1.
Mean plasma concentration-time curves of sulfadimidine (100 mg/kg) in male and female WAD goats following intramuscular administration.
Figure 2.
Mean plasma concentration-time curves of sulfadimidine (100 mg/kg) when co-administered with piroxicam (5 mg/kg) to male and female WAD goats following intramuscular administration.
However, peak time (Tmax) and Cmax can be estimated from the pharmacokinetic graph [47].
4.1 Comparative pharmacokinetics of antimicrobials in domestic goats
Species variations in response to antimicrobials are very important. Various antimicrobials from different chemical classes, their routes of administration, doses, elimination half-life, bioavailability, maximal concentration, peak time, breed and spectra of activity are presented in Table 1. The therapeutic doses of fluoroquinolones in goats are 1.2 mg/kg subcut for levofloxacin, 5 mg/kg i.v. (orfloxacin, enrofloxacin, norfloxacin and gatifloxacin) and 20 mg/kg oral (pefloxacin). The elimination half-life (2.8 ± 0.02 h) of kanamycin (5 mg/kg) and half-life (1.94 ± 0.1 h) of amikacin (10 mg/kg) in Teddy and Indian native goat, respectively, show that the disposition kinetics of aminoglycosides in goats is dependent on the dose of drugs. Also, disposition kinetics of antimicrobials in goats could be species dependent. For example, Cmax (236.3 ± 0.00 μg/ml) of sulfadimidine in West African dwarf (Figure 1) is higher than that of Pakistan female goat (6.0 ± 3.0 μg/ml) and Shiba goat (2.14 ± 1.05 μg/ml), respectively [16]. Tmax of West African dwarf (1.1 ± 0.3 h) is lower than that of Shiba (2.0 ± 1.2 h) and Netherland dwarf (2.0 ± 0.5 h), respectively [18, 19]. But Vd (3.9 ± 0.8 L/kg) in West African dwarf is higher than that of Nubian (0.32 ± 0.0 L/kg), Shiba (0.4 ± 0.2 L/kg) and cross-breed (0.3–0.5 L/kg), respectively [17, 19, 20], suggesting the difference in breed response to antimicrobials. However, half-life of kanamycin (5 mg/kg) was higher in buffaloes (4.35 ± 0.24 h), cow (6.0 ± 0.50 h) and sheep (3.4 ± 0.1 h) than that of goat (2.8 ± 0.2 h), respectively, indicating that goat is the species most sensitive to kanamycin among these species of herbivores. Also, difloxacin is effective at 5 mg/kg [8]. But normal milk reduces the activity of enrofloxacin against E. coli [50]. However, T1/2β (1.94 ± 0.1 h) of kanamycin for normal goat is lower than the T1/2β (3.17 ± 0.13 h) for febrile goat. Maintenance of therapeutic concentration (2 mg/ml) requires a priming dose of 14.73 mg/kg and maintenance dose of 13.95 mg/kg at an 8-h interval, respectively [8]. Plasma concentration of levofloxacin is higher in healthy goats (15.51 ± 1.41 μg/ml) than mastitis goats (12.48 ± 1.36 kg/ml). This plasma concentration does not affect levofloxacin elimination [9].
Since various brands of enrofloxacin have different pharmacokinetic parameters such as half-life (3.93 ± 0.46; 4.04 ± 0.53; 4.56 ± 1.24 h) and plasma concentrations (15.53 ± 1.31; 6.75 ± 0.56; 10.40 ± 2.65 μg/ml) [28], dosage formulations may have sufficient effects on pharmacokinetics and pharmacodynamics of aminoglycosides. Serum concentration of gentamicin (5 mg/kg) was maintained at 1.5–12 μg/ml for a period of 6 h. But gentamicin (2.5–3.0 mg/kg i.m.) every 8 h is therapeutically useful with less risk of nephrotoxicity [29], as daily intravenous administration of 4 mg/kg is effective for 36 h in the treatment of systemic and urinary tract infections caused by Gram-negative pathogens in goats [30]. Therefore, optimal dosage regimen, bioequivalence and kinetic parameters of antimicrobials are of clinical importance [31]. Elimination half-life, Cmax and Tmax of intramuscular enrofloxacin (2.5 mg/kg) are 5.39 ± 0.96 h, 1.14 ± 0.09 μg/ml and 0.83 ± 0.13 h, respectively [51]. Gatifloxacin (5 mg/kg) provided minimum inhibitory concentration (MIC) of 0.1–2 μg/ml for susceptible microorganisms between 6 and 12 h in healthy and febrile goats, respectively [32]. Elimination half-life (3.98 ± 0.18 h), Cmax (9.24 ± 1.2 μg/ml), MRT (4.13 ± 0.16 h), Vdss (1.22 ± 0.06 L/kg) and Clb (0.24 ± 0.01 l/h/kg) of enrofloxacin (5 mg/kg) have been reported [6]. The Vd (3.35 ± 0.45 L/kg), Clb (0.28 ± 0.03 l/h/kg) and T1/2β (9.99 ± 2.83 h) suggest long persistence of lincomycin in goat as it can be repeated every 24 h with MIC (0.6 μg/ml) for treatment of febrile bacterial infections in goats [33]. But intramuscular lincomycin can be administered every 12 h [34].
Vancomycin was initially active against methicillin-resistant Staphylococcus, but presently vancomycin-resistant Staphylococcus has emerged, and vancomycin-resistant Enterococcus has also emerged due to its usage as feed additive. Hence, prophylactic use of antibiotics should be highly reduced [52]. Concentration of pefloxacin (0.25 μg/ml) was maintained in plasma for 6–10 h after oral or intravenous administration. Therefore, intravenous pefloxacin (20 mg/kg) every 6 h or thrice orally is effective against sensitive pathogenic microbes in goats [36]. But intravenous dose (10 mg/kg) of ciprofloxacin with T1/2β (2.72 ± 1.04 h), MRT (3.33 ± 1.42 h), Vdss (3.37 ± 0.8 l/kg) and Clb (19.59 ± 9.05 ml/min/kg), respectively, should be administered every 12 h [53]. Cefpirome (10 mg/kg) every 12 h is useful when administered intravenously in goats. It is 19.9% plasma protein bound [37] and so may compete weakly with other plasma-binding drugs such as sulfadimidine, warfarin, non-steroidal anti-inflammatory drugs and barbiturates. The long half-life of azithromycin after intravenous (45.2 h) and intramuscular (32.5 h) administration and MRT of 40.1 h and 60.3 h and bioavailability of 92.2% [38] show that the drug could be administered every 2 and 3 days, respectively. But half-life (67.2 h) of tulathromycin (25 mg/kg) indicates that the withdrawal period of tulathromycin may be long and there may not be a need for repeated doses of the drug. But elimination of erythromycin is higher in lactating goats (3.18 ± 1.32 h) than non-lactating goats (1.41 ± 1.20 h) [39] signifying that erythromycin is quickly removed from the body of non-lactating goats. MIC of erythromycin against Staphylococcus aureus was 0.50 and 0.75 μg/ml [54], respectively. Tylosin (10–15 mg/kg) was administered to goats both intramuscularly and intravenously. The intramuscular bioavailability was 72.6%, and serum protein binding was 37.6%, Cmax (2.38 μg/ml), Vd (1.7 L/kg), T1/2β (3.04 h), Tmax (4.19 h) and Clb (6.8 ml/kg/min), respectively. Hence, tylosin should be injected every 14 h [43]. Gentamicin (4 mg/kg), amikacin (10 mg/kg), tobramycin (5 mg/kg), kanamycin (10 mg/kg) and apramycin (20 mg/kg) may have synergistic or additive antibacterial activity [55]. Intramuscular metronidazole can be administered to goats at 10 mg/kg body weight every 12 h [4]. Oxytetracycline (10 mg/kg), ampicillin (20 mg/kg) and combination of trimethoprim (20 mg/kg), sulfamethazine (50 mg/kg) and sulphamethyl phenazine (50 mg/kg) are effective in treatment of ehrlichiosis [56]. But extensive and very wide use of antimicrobial agents in goats may portend very high risk of resistance [57]. Therefore, each antimicrobial must be studied on species basis for effective and safe use for animal well-being and public safety in terms of animal product consumption and human/animal drug resistance [3].
4.2 Pharmacokinetics of antimicrobials in wild goats
Although the information on pharmacokinetics of wild goats is rare, allometric scaling can be applied for extrapolation of some parameters including Vd and Cl except T1/2β [58]. Ceftazidime (10 mg/kg) administered to Creole goat showed high serum concentration, good penetration and high bioavailability of the drug [45]. But cephalexin (10 mg/kg) administered (subcut, i.m. and i.v.) to Lama glama showed high bioavailability of 72% (i.m.) and 89% (i.v.), respectively. The MIC90 values of cephalexin against coagulase-positive staphylococci and E. coli were 1.0 μg/ml and 8.0 μg/ml, respectively [59]. But MIC90 value (0.01–0.1 μg/ml) of ceftazidime against E. coli, Salmonella species, Pasteurella haemolytica and P. multocida [45] shows that ceftazidime is more active and efficacious than cephalexin, which can be administered 8 mg/kg i.m. or subcut every 12 or 24 h, respectively [59]. Other modes of administration such as ballistic implants and impregnated beads can be employed for some antimicrobials to avoid frequent administration as seen in cefovecin with very long half-life in dogs and cats, allowing a dosing interval of 14 days [60, 61]. This strategy may reduce the chance of resistance by microorganisms against antimicrobials. For example, an amoxicillin formulation with half-life of 130 h can be administered every 6 days, and ceftiofur with half-life of 37 h can be administered every 2 days in goats [62]. Orbifloxacin administered to Mehsana goat (2.5 mg/kg i.v.) with T1/2β (8.63 ± 0.13 h), Vdss (2.99 ± 0.04 l/kg), MRT (21.07 ± 0.8 h) and bioavailability (155.5%) showed antimicrobial activity against E. faecalis, S. epidermidis, S. intermedius, S. aureus, S. pyogenes, E. coli, S. typhimurium, S. typhi, S. enterica, Shigella flexneri, K. pneumonia, E. aerogenes, P. aeruginosa, P. mirabilis, Pasteurella species, Mycoplasma species and Mannheimia haemolytica [63].
4.3 Pharmacodynamics of antimicrobials
Pharmacokinetics determine maximal therapeutic effect that depends on plasma drug concentration, drug receptors, health status and co-administration of antimicrobial with another drug that shares same or different binding receptors. Slowly eliminated and accumulated antimicrobials are least compared by poor dosing interval [64]. The maximal effect of antimicrobials is dependent on molecule-receptor interaction and drug-affinity response. Therefore,
DrugsD+receptorR⇄k1DRk2E19
Affinity constantKaff=k1k2E20
Kaff=1ED50E21
However, antimicrobial treatments can be monitored as follows:
Dosenew=CpssmeasuredCpssdesired×DosepreviousE22
But Cpss is achieved when antimicrobial is administered repeatedly at different time intervals.
Therapeutic indexTIis definedasa ratio ofLethal dose fiftyLD50Effective dosefiftyED50E23
However, when the body weight of goat is reduced by diarrhea or intoxicated by antimicrobials, there may be a need for fluid infusion to maximize balanced pharmacokinetic/pharmacodynamic process of antimicrobials. Clinical correlates of weight loss as a measure of dehydration (>5–12%) must be considered.
Drops/minute=volume of infusionmltime of infusionmin×drop factordrops/mlE25
Only half of calculated deficit should be administered in 1–2 h. Half replacement in 4–6 h is safer and should be completed in 2 days [65]. Isotonic solutions such as 5% dextrose and 0.9% normal saline can be administered via all routes. But hypotonic and hypertonic solutions should be administered intravenously to avoid tissue reaction.
Weighted AUC approach accounts for a more powerful PK/PD link and reveals uniqueness outcome of therapeutic indices and problems of antibiotic resistance [66]. A combination of ampicillin/sulbactam (20 mg/kg) in ratio 2:1 was administered to goat with elimination half-life of ampicillin (0.71 ± 0.12 h), and sulbactam (1.02 ± 0.36 h) shows that the preparation could be administered at the same dosing rate in both sheep and goats [67]. Also, intramuscular dose (2 mg/kg) of cefquinome (Cobactan 2.5%) daily yielded effective MICs against a variety of susceptible pathogenic microbes of goat including Micrococcus luteus [68]. Serum concentration and AUC integrated with MIC values can predict clinical success. The efficacy of macrolides, penicillins and tetracyclines is determined by the length of time, the serum concentration exceeds the MIC of a pathogenic microbe. But fluoroquinolones, aminoglycosides and metronidazole have concentration-dependent bactericidal activity [69]. The ratio of Cmax/MIC indicates potential of antibacterial activity. Amikacin has the lowest MIC90, whereas kanamycin has the highest [55]. Co-administration of two or more drugs could also affect pharmacokinetics and pharmacodynamics of a drug. For example, West African dwarf goats are more sensitive to sulfadimidine co-administered with piroxicam (Figure 2) [15].
4.4 Intraspecies and interspecies scaling of antimicrobials in goats
Variation is an important factor in development of antimicrobials for all species of animals including wild and domestic goats. The problems encountered are how to scale up the pharmacokinetic data from animals to human and how to extrapolate in vitro data to in vivo data for efficacy and safety [70]. There is no enough data on toxicological effects of antimicrobials in goats. Hence, several extrapolations are necessary in order to arrive at safe therapeutic and toxic doses [71]. The effective therapeutic doses of some antimicrobials translated from goats to human are given in Table 2.
The formulas used for calculation of extrapolated doses are as follows [13, 72, 73].
Human equivalent doseHED=animal dose×animalKmhumanKmE27
But goat’s BSA = WO.67 × 10−3 and dosimetric adjustment factor (DAF) is body weight of goat over body weight of humans and can be scaled up to 0.25, 0.33 and 0.58. However, body weight exponent of 0.67 and 10−3 safety factor should be applied to goat, and the exponent of 0.528 should be applied to human weight and height, respectively [72, 74].
4.5 Antimicrobial tissue residues in goats
Tissue residues of some antimicrobials above recommended thresholds are of public health importance. The presence of sulfadimidine residues (>0.1 ppm) in the liver, kidney, skeletal muscle, spleen, lung, brain and heart after administration of the drug (100 mg/kg) shows that the withdrawal period is longer than 30 days. Hence, sulfadimidine is not easily excreted in West African dwarf goats [13]. This may be due to the presence of desamino-sulfonamide, a sulfadimidine metabolite [75] which is eliminated slowly, thereby increasing the withdrawal time [76]. Lack of adequate water to dilute crystals of sulfadimidine in the kidney can lead to crystalluria that can consequently cause nephrosis in the affected animals [44], and consumptions of meats with high residues of sulfadimidine can cause Steven-Johnson syndrome in sensitive humans who may be slow or fast acetylators [13, 23]. Based on the tissue tolerance limit in cattle (5 ppm), the withdrawal period for tulathromycin is 19 days in cattle and 34 days in goat when administered subcutaneously [5]. The quantity of erythromycin residues (2.06 ± 0.36 μg) is above the recommended threshold and may portend risk to public health. The bioavailability of tylosin in goat is 72.6± 2.3%, and its withdrawal period (48 h) [43] shows that the higher the bioavailability, the lower may be the withdrawal period in milk. Residues of antimicrobials in various tissues are presented in Table 3. A kid that feeds on milk with residues of antimicrobials may be vulnerable to resistance of microorganisms against the antimicrobials.
4.6 Antimicrobial resistance
Goats are exposed to antimicrobials via prevention, treatment of diseases and growth promotion. This has caused the emergence of resistant Salmonella, Campylobacter, Pasteurella, Actinobacillus, Enterococcus and Escherichia species. The resistance is transferred by genes. But good and improved management practices and increased use of vaccines and probiotics could minimize emergence and spread of resistance genes [77].Off-label use of antimicrobials in goats could also contribute to emergence of resistance. Meanwhile, lack of official-generated data on consequences of extra-label use of drugs in goats cannot rule out its potential risks to goats and other species of animals [78]. However, T-phage, transposon and integrin are used for resistance gene transfer. Unfortunately, the worldwide consumption of antimicrobial drugs is increasing, and the manufacturing industries are not keeping pace. The worst of it at the moment is the emergence of superbugs and super drugs. Therefore, there is a need for green antibiotics to minimize the chance of resistance [79].
4.7 Determination of creatinine and glomerular filtration rate as indices of renal function in goats
Kidneys are responsible for water-electrolyte balance in the body, usually affected by activity-rest rhythm under hormonal influence. The diurnal changes are useful in chronobiology and chronopharmacology [80]. Many xenobiotics including antimicrobials are toxic to the kidney, and renal impairment can be assessed using creatinine clearance which is physiologically, pharmacologically and toxicologically related to body weight, clearance, volume of urine creatinine, plasma creatinine, serum creatinine, urine volume, glomerular filtration rate, creatinine clearance, creatinine half-life and depuration [81]. The plasma creatinine of Boer-Cross (0.60 mg/dl), Nubian (0.55 mg/dl) and Spanish (0.57 mg/dl) goat have been reported [82], whereas creatinine value (1.03–1.24 mg/dl) has been reported for healthy captive, Persian wild goat [83]. Area under curve could be used to determine creatinine clearance and plasma clearance as demonstrated in the equations given below [81].
DoseD=AUC×CrCl+25E30
Pcl=CrCl+25E31
CrCl=Pcl–25E32
GFR=14616.8Crt1/2E33
DepurationDep=UcrPcrE34
Serum creatinineScr=Ucr1440×10001000ml=1lE35
Creatinine clearanceCrCl=UcrPcr×144E36
For example, paracetamol reduced glomerular filtration rate and induced less urinary excretion of isoniazid. Also, renal handling of isoniazid involved glomerular filtration, back diffusion and active tubular secretion [84]. Glomerular filtration rate which is a function of creatinine clearance can be affected by environmental and genetic factors as may be seen in native Pakistan goats administered ampicillin (20 mg/kg) with renal clearance of 0.08 ml/min/kg [85]. Hence, GFR is lower in Pakistan native than the foreign goats [86] unlike renal handling of marbofloxacin in Lohi sheep that involves both glomerular filtration and active tubular secretion [87] indicating that environment has physiological effects on various breeds of goats. This agrees with Bergmann’s rule which states that light animals tend to live in hot regions of the world as opposed to fatty animals that tend to live in cold regions [88]. Since 8% of total body weight determines total blood volume, red cell volume and plasma volume could also be determined from hematocrit as indicated in the equation given below [89].
Total blood volume=plasma×100/100–hematocritE37
Long-time administration of sulfadimidine over a period of 1 week may cause hemolysis leading to anemia [90]. Hence, the formula can be used to determine anemia and plasma deficit in goats, photos 1-46 [1, 2, 21, 22, 24].
1, Abergelle goat; 2, Afar goat; 3, African pygmy goat; 4, Altai mountain goat; 5, American Alpine doe; 6, Anglo Nubian goat; 7, Angora goat; 8, Ardi goats in the Arabian Peninsula; 9, Attappady black goat; 10, Babrbari-goat-breed; 11, Beetal-South Asia; 12, Black Bengal goat; 13, Black Oberhasli; 14, Bosque Valley Boer goats; 15, British primitive (Feral goat); 16, Dairy goat; 17, Dutch Toggenburger; 18, Eid-goat; 19, Indian Boer male goat; 20, Italian Adamello blond; 21, Kalahari-red-goat; 22, Marciano-Granadina; 23, Markhor wild goat; 24, Markhor-Pakistan; 25, Murciana goat; 26, Nederlandse Landgeit; 27, Nigeria West African dwarf goat; 28, Nubian blackgold goat; 29, Nubian-Ryan-Somma; 30, Oberhasli goats; 31, Osmanabadi goat; 32, Pakistan Bakra goat; 33, Paaltu Bakri-Nashik goat; 34, Shiba goat; 35, Pure-white-Tappra-teddy-male-goat; 36, Saanen-goat-in-Pakistan-Urdu; 37, Sangamneri-South Asia pro-poor; 38, Shatner goat; 39, Sirohi-male-kid-goat; 40, Sojat-goat; 41, Sokoto Red goat; 42, Teddy-tapra-bakra-goat; 43, Toggenburgerbok goat; 44, Toggenburg-Nigerian-dwarf-Oberhasli-goat; 45, Valachian goat; 46, White Barbari-goat.
5. Conclusion
Pharmacokinetic, pharmacodynamic, intraspecies and extraspecies scaling are some parameters that can affect physiological functions of antimicrobials in goats. Lack of judicious and extralabel use of antimicrobials in goats could cause high tissue residues and development of resistance by susceptible microorganisms against the antimicrobials in both goats and humans. Tissue residues of sulfadimidine may cause Stevens-Johnson syndrome in the vulnerable individuals. Dehydrated goats may be more susceptible to antimicrobial toxicity. GFR can be used to assess the level of kidney damage caused by antimicrobials, and rehydration therapy is useful in dissolution of antimicrobial crystals formed in the kidney. In case of fervent need for extralabel use of antimicrobials, the relevant formulas reported herein could be used to translate goat dose to human dose and vice versa.
\n',keywords:"pharmacokinetics, pharmacodynamics, goat, tissue residue, human equivalent dose, resistance, receptor, agonism, antagonism",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/66201.pdf",chapterXML:"https://mts.intechopen.com/source/xml/66201.xml",downloadPdfUrl:"/chapter/pdf-download/66201",previewPdfUrl:"/chapter/pdf-preview/66201",totalDownloads:1150,totalViews:0,totalCrossrefCites:1,dateSubmitted:"July 9th 2018",dateReviewed:"January 18th 2019",datePrePublished:"May 3rd 2019",datePublished:"July 15th 2020",dateFinished:"March 19th 2019",readingETA:"0",abstract:"Pharmacokinetics, the process that involves drug absorption, distribution, metabolism and excretion (ADME) of antimicrobials, determines pharmacodynamic response, that is, what drugs do to the body. Therefore, of all the pharmacokinetic parameters, elimination half-life (T1/2β), volume of distribution (Vd), maximum plasma concentration (Cmax) and maximum time reached (Tmax) are the most important parameters. Hence, the parameters are unique in determining pharmacokinetic and pharmacodynamic response of antimicrobials. However, it is elimination half-life and minimum inhibitory concentration (MIC) that determine the dosing interval of antimicrobials. The dose range of 2.5 mg/kg for gentamicin passing through 4 mg/kg (ciprofloxacin), 4.2 mg/kg (ampicillin L/A), 5 mg/kg (kanamycin, enrofloxacin, gatifloxacin and norfloxacin), 7 mg/kg (mequindox), 10 mg/kg (amikacin, enrofloxacin, lincomycin, pefloxacin, cefpirome, erythromycin and isoniazid), 20 mg/kg (oxytetracycline) and 30 mg/kg (metronidazole) have elimination half-life of 1.2–67.2 h, Cmax of 0.12–54.4 μg/ml, Tmax of 0.2–24 h, bioavailability of 16–99.8% and plasma protein binding of 0–>80% when administered intramuscularly, intravenously and orally. Human equivalent dose formula could be used to extrapolate human-goat therapeutic doses of antimicrobials. However, some antimicrobials such as sulfadimidine, tulathromycin, oxytetracycline and azithromycin may have high residues in the milk, kidneys, liver, intestines, brain and skeletal muscles and may portend high risk of antimicrobial resistance, hypersensitivity reaction, epidermal necrolysis, Stevens-Johnson syndrome and other adverse drug reactions.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66201",risUrl:"/chapter/ris/66201",signatures:"Saganuwan Alhaji Saganuwan",book:{id:"7019",type:"book",title:"Goats (Capra)",subtitle:"From Ancient to Modern",fullTitle:"Goats (Capra) - From Ancient to Modern",slug:"goats-capra-from-ancient-to-modern",publishedDate:"July 15th 2020",bookSignature:"Sándor Kukovics",coverURL:"https://cdn.intechopen.com/books/images_new/7019.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83881-053-5",printIsbn:"978-1-83881-049-8",pdfIsbn:"978-1-83881-054-2",isAvailableForWebshopOrdering:!0,editors:[{id:"25894",title:"Prof.",name:"Sándor",middleName:null,surname:"Kukovics",slug:"sandor-kukovics",fullName:"Sándor Kukovics"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"266889",title:"Prof.",name:"Saganuwan",middleName:null,surname:"Alhaji Saganuwan",fullName:"Saganuwan Alhaji Saganuwan",slug:"saganuwan-alhaji-saganuwan",email:"pharn_saga2006@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methodology",level:"1"},{id:"sec_3",title:"3. Results",level:"1"},{id:"sec_3_2",title:"3.1 Biopharmaceutical classification of oral antimicrobials",level:"2"},{id:"sec_4_2",title:"3.2 Pharmacokinetic equations of antimicrobials",level:"2"},{id:"sec_6",title:"4. Discussion",level:"1"},{id:"sec_6_2",title:"4.1 Comparative pharmacokinetics of antimicrobials in domestic goats",level:"2"},{id:"sec_7_2",title:"4.2 Pharmacokinetics of antimicrobials in wild goats",level:"2"},{id:"sec_8_2",title:"4.3 Pharmacodynamics of antimicrobials",level:"2"},{id:"sec_9_2",title:"4.4 Intraspecies and interspecies scaling of antimicrobials in goats",level:"2"},{id:"sec_10_2",title:"4.5 Antimicrobial tissue residues in goats",level:"2"},{id:"sec_11_2",title:"4.6 Antimicrobial resistance",level:"2"},{id:"sec_12_2",title:"4.7 Determination of creatinine and glomerular filtration rate as indices of renal function in goats",level:"2"},{id:"sec_14",title:"5. 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Pakistan Journal of Biological Sciences. 2003;6(11):1005-1008'},{id:"B11",body:'Aktas I, Tarsan E. Pharmacokinetics of conventional and long-acting oxytetracycline preparations in kais goat. Frontiers in Veterinary Science. 2017;4:229'},{id:"B12",body:'Nureen H, Igbal Z, Hasnain J, Khan AA. Biodisposition of isoniazid after oral administration in teddy goats. Israel Medical Journal. 2011;3(1):07-09'},{id:"B13",body:'Akogwu EI, Saganuwan SA, Onyeyili PA. Effects of piroxicam on tissue distribution of sulfadimidine in west African dwarf male and female goats. HET. 2018;37(1):61-68'},{id:"B14",body:'Zhao R, Xiao W, Wang Y, Yan X, Zhou Z, Li J, et al. Initial observation of the bacteriostasis activity and toxicity of NAQO and MCEQO. Journal of Traditional Clinical Veterinary Medicine. 1982;1:51-54'},{id:"B15",body:'Akogwu EI, Saganuwan SA, Onyeyili PA. Effects of piroxicam on pharmacokinetics of sulphadimidine in west African dwarf male and female goats (Capra hircus). Pharmaceutica Analytica Acta. 2017;8(555):1-7'},{id:"B16",body:'Nawaz M, Khan FH. Pharmacokinetics and urinary excretion of sulphadimidine in sheep and goats. Journal of Veterinary Pharmacology and Therapeutics. 1979;2:129-132'},{id:"B17",body:'Elbadawy M, Ishihara T, Aboubakar M, Sasaki K, Shimoda M. Oral absorption profiles of sulfonamides in Shiba goats: A comparison among sulfadimidine, sulfadiazine and sulfanilamide. The Journal of Veterinary Medical Science. 2016;78(6):1025-1029'},{id:"B18",body:'Van Gogh H, Van Deurzen EJM, Van Duin CTM, Van Miert ASJPAM. Effect of staphylococcal enterotoxin β-induced diarrhoea on the pharmacokinetics of sulphadimidine in the goats. Journal of Veterinary Pharmacology and Therapeutics. 1984;7:303-305'},{id:"B19",body:'Elsheikh HA, Ali BH, Homeida AM, Hassan T, Hapke HJ. Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats. 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Small Ruminant Research. 2005;59:15-23'},{id:"B83",body:'Omidi A, Nik HA, Nazifi S. Biochemical reference values for healthy captive Persian wild goat. Comparative Clinical Pathology. 2017:1-10'},{id:"B84",body:'Hussain T, Javed I, Khan FH, Muhammad F, Aslam B, Ahmad S. Effect of paracetamol on the renal clearance and urinary excretion of isoniazid in goats. Pakistan Veterinary Journal. 2009;29(3):121-124'},{id:"B85",body:'Nawaz M. Genetic variations of ampicillin in indigenous sheep and goat of Pakistan. In: 1st International Congress of Veterinary Pharmacology and Pharmaceutical Sciences; Oct 4-5, 2008; Tehran Iran'},{id:"B86",body:'Iqbal Z, Javed I, Aslam B, Muhammad F, Jan IU. Renal clearance and urinary excretion of ciprofloxacin in goats. Pakistan Veterinary Journal. 2007;27(4):179-183'},{id:"B87",body:'Munawar SH, Iqbal, Manzoor Z. Determination of renal handling of marbofloxacin in Lohi sheep (Ovis aries) following a single intravenous administration. Iran Journal of Veterinary Research. 2017;18(1):45-55'},{id:"B88",body:'Saganuwan SA. Toxicity studies of drugs and chemicals in animals: An over view. Bulgarian Journal of Veterinary Medicine. 2017;20(4):1-28'},{id:"B89",body:'Saganuwan SA, Onyeyili PA. Haematonic and plasma expander effects of aqueous leaf extract of Abrus precatorius in Mus musculus. Comparative Clinical Pathology. 2012;21(5):1249-1255'},{id:"B90",body:'Saganuwan SA. Haematological and biochemical effects of sulphadimidine in Nigerian mongrel dog. Animal Research International. 2006;3(2):457-460'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Saganuwan Alhaji Saganuwan",address:"pharn_saga2006@yahoo.com",affiliation:'
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Our journals are currently in their launching issue. They will be applied to all relevant indexes as soon as they are eligible. These include (but are not limited to): Web of Science, Scopus, PubMed, MEDLINE, Database of Open Access Journals (DOAJ), Google Scholar and Inspec.
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IntechOpen books are indexed by the following abstracting and indexing services:
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BKCI is a part of Web of Science Core Collection (WoSCC) and the world’s leading citation index with multidisciplinary content from the top tier international and regional journals, conference proceedings, and books. The Book Citation Index includes over 104,500 editorially selected books, with 10,000 new books added each year. Containing more than 53.2 million cited references, coverage dates back from 2005 to present. The Book Citation Index is multidisciplinary, covering disciplines across the sciences, social sciences, and arts & humanities.
Produced by the Web Of Science group, BIOSIS Previews research database provides researchers with the most current sources of life sciences information, including journals, conferences, patents, books, review articles, and more. Researchers can also access multidisciplinary coverage via specialized indexing such as MeSH disease terms, CAS registry numbers, Sequence Databank Numbers and Major Concepts.
Produced by the Web Of Science group, Zoological Record is the world’s oldest continuing database of animal biology. It is considered the world’s leading taxonomic reference, and with coverage back to 1864, has long acted as the world’s unofficial register of animal names. The broad scope of coverage ranges from biodiversity and the environment to taxonomy and veterinary sciences.
Provides a simple way to search broadly for scholarly literature. Includes peer-reviewed papers, theses, books, abstracts and articles, from academic publishers, professsional societies, preprint repositories, universities and other scholarly organizations. Google Scholar sorts articles by weighing the full text of each article, the author, the publication in which the article appears, and how often the article has been cited in other scholarly literature, so that the most relevant results are returned on the first page.
Microsoft Academic is a project exploring how to assist human conducting scientific research by leveraging machine’s cognitive power in memory, computation, sensing, attention, and endurance. Re-launched in 2016, the tool features an entirely new data structure and search engine using semantic search technologies. The Academic Knowledge API offers information retrieval from the underlying database using REST endpoints for advanced research purposes.
The national library of the United Kingdom includes 150 million manuscripts, maps, newspapers, magazines, prints and drawings, music scores, and patents. Online catalogues, information and exhibitions can be found on its website. The library operates the world's largest document delivery service, providing millions of items a year to national and international customers.
The digital NSK portal is the central gathering place for the digital collections of the National and University Library (NSK) in Croatia. It was established in 2016 to provide access to the Library’s digital and digitized material collections regardless of storage location. The digital NSK portal enables a unified search of digitized material from the NSK Special Collections - books, visual material, maps and music material. From the end of 2019, all thematic portals are available independently: Digital Books, Digitized Manuscripts, Digitized Visual Materials, Digital Music Materials and Digitized Cartographic Materials (established in 2017). Currently available only in Croatian.
The official DOI (digital object identifier) link registration agency for scholarly and professional publications. Crossref operates a cross-publisher citation linking system that allows a researcher to click on a reference citation on one publisher’s platform and link directly to the cited content on another publisher’s platform, subject to the target publisher’s access control practices. This citation-linking network covers millions of articles and other content items from several hundred scholarly and professional publishers.
Dimensions is a next-generation linked research information system that makes it easier to find and access the most relevant information, analyze the academic and broader outcomes of research, and gather insights to inform future strategy. Dimensions delivers an array of search and discovery, analytical, and research management tools, all in a single platform. Developed in collaboration with over 100 leading research organizations around the world, it brings together over 128 million publications, grants, policy, data and metrics for the first time, enabling users to explore over 4 billion connections between them.
The primary aim of DOAB (Directory of Open Access Books) is to increase discoverability of Open Access books. Metadata will be harvestable in order to maximize dissemination, visibility and impact. Aggregators can integrate the records in their commercial services and libraries can integrate the directory into their online catalogues, helping scholars and students to discover the books.
OAPEN is dedicated to open access, peer-reviewed books. OAPEN operates two platforms, the OAPEN Library (www.oapen.org), a central repository for hosting and disseminating OA books, and the Directory of Open Access Books (DOAB, www.doabooks.org), a discovery service for OA books.
OpenAIRE aims at promoting and implementing the directives of the European Commission (EC) and the European Research Council on the promotion and funding of science and research. OpenAIRE supports the Open Access Mandate and the Open Research Data Pilot developed as part of the Horizon 2020 projects.
An integrated information service combining reference databases, subscription management, online journals, books and linking services. Widely used by libraries, schools, government institutions, medical institutions, corporations and others.
SFX® link resolver gives patrons and librarians a wealth of features that optimize management of and access to resources. It provides patrons with a direct route to electronic full-text records through OpenURL linking, delivers alternative links for further resource discovery, access to journals, and more. Released in 2001 as the first OpenURL resolver, SFX is continuously enhanced to support the newest industry developments and meet the evolving needs of customers. The records include a mix of scholarly material – primarily articles and e-books – but also conference proceedings, newspaper articles, and more.
A non-profit, membership, computer library service and research organization dedicated to the public purposes of furthering access to the world's information and reducing information costs. More than 41,555 libraries in 112 countries and territories around the world use OCLC services to locate, acquire, catalogue, lend and preserve library materials.
The world’s largest collection of open access research papers. CORE's mission is to aggregate all open access research outputs from repositories and journals worldwide and make them available to the public. In this way CORE facilitates free unrestricted access to research for all.
Since 2002, Research4Life has provided researchers at more than 10,500 institutions in over 125 lower and middle-income countries with free or low-cost online access to up 151,000 leading journals and books in the fields of health, agriculture, environment, applied sciences and legal information. There are five programs through which users can access content: Research for Health (Hinari), Research in Agriculture (AGORA), Research in the Environment (OARE), Research for Development and Innovation (ARDI) and Research for Global Justice (GOALI).
Perlego is a digital online library focusing on the delivery of academic, professional and non-fiction eBooks. It is a subscription-based service that offers users unlimited access to these texts for the duration of their subscription, however IntechOpen content integrated on the platform will always be available for free. They have been billed as “the Spotify for Textbooks” by the Evening Standard. Perlego is based in London but is available to users worldwide.
MyScienceWork provides a suite of data-driven solutions for research institutions, scientific publishers and private-sector R&D companies. MyScienceWork's comprehensive database includes more than 90 million scientific publications and 12 million patents.
CNKI (China National Knowledge Infrastructure) is a key national information construction project under the lead of Tsinghua University, and supported by PRC Ministry of Education, PRC Ministry of Science, Propaganda Department of the Communist Party of China and PRC General Administration of Press and Publication. CNKI has built a comprehensive China Integrated Knowledge Resources System, including journals, doctoral dissertations, masters' theses, proceedings, newspapers, yearbooks, statistical yearbooks, ebooks, patents, standards and so on. CNKI keeps integrating new contents and developing new products in 2 aspects: full-text academic resources, software on digitization and knowledge management. Began with academic journals, CNKI has become the largest and mostly-used academic online library in China.
As one of the largest digital content platform in China,independently developed by CNPIEC, CNPeReading positions herself as “One Platform,Vast Content, Global Services”. Through their new cooperation model and service philosophy, CNPeReading provides integrated promotion and marketing solutionsfor upstream publishers, one-stop, triune, recommendation, online reading and management servicesfor downstream institutions & libraries.
ERIC (Education Resources Information Center), sponsored by the Institute of Education Sciences (IES) of the U.S. Department of Education, provides access to education literature to support the use of educational research and information to improve practice in learning, teaching, educational decision-making, and research. The ERIC website is available to the public for searching more than one million citations going back to 1966.
The ACM Digital Library is a research, discovery and networking platform containing: The Full-Text Collection of all ACM publications, including journals, conference proceedings, technical magazines, newsletters and books. A collection of curated and hosted full-text publications from select publishers.
BASE (Bielefeld Academic Search Engine) is one of the world's most voluminous search sengines especially for academic web resources, e.g. journal articles, preprints, digital collections, images / videos or research data. BASE facilitates effective and targeted searches and retrieves high quality, academically relevant results. Other than search engines like Google or Bing BASE searches the deep web as well. The sources which are included in BASE are intellectually selected (by people from the BASE team) and reviewed. That's why data garbage and spam do not occur.
Zentralblatt MATH (zbMATH) is the world’s most comprehensive and longest-running abstracting and reviewing service in pure and applied mathematics. It is edited by the European Mathematical Society (EMS), the Heidelberg Academy of Sciences and Humanities and FIZ Karlsruhe. zbMATH provides easy access to bibliographic data, reviews and abstracts from all areas of pure mathematics as well as applications, in particular to natural sciences, computer science, economics and engineering. It also covers history and philosophy of mathematics and university education. All entries are classified according to the Mathematics Subject Classification Scheme (MSC 2020) and are equipped with keywords in order to characterize their particular content.
IDEAS is the largest bibliographic database dedicated to Economics and available freely on the Internet. Based on RePEc, it indexes over 3,100,000 items of research, including over 2,900,000 that can be downloaded in full text. RePEc (Research Papers in Economics) is a large volunteer effort to enhance the free dissemination of research in Economics which includes bibliographic metadata from over 2,000 participating archives, including all the major publishers and research outlets. IDEAS is just one of several services that use RePEc data.
As the authoritative source for chemical names, structures and CAS Registry Numbers®, the CAS substance collection, CAS REGISTRY®, serves as a universal standard for chemists worldwide. Covering advances in chemistry and related sciences over the last 150 years, the CAS content collection empowers researchers, business leaders, and information professionals around the world with immediate access to the reliable information they need to fuel innovation.
BKCI is a part of Web of Science Core Collection (WoSCC) and the world’s leading citation index with multidisciplinary content from the top tier international and regional journals, conference proceedings, and books. The Book Citation Index includes over 104,500 editorially selected books, with 10,000 new books added each year. Containing more than 53.2 million cited references, coverage dates back from 2005 to present. The Book Citation Index is multidisciplinary, covering disciplines across the sciences, social sciences, and arts & humanities.
Produced by the Web Of Science group, BIOSIS Previews research database provides researchers with the most current sources of life sciences information, including journals, conferences, patents, books, review articles, and more. Researchers can also access multidisciplinary coverage via specialized indexing such as MeSH disease terms, CAS registry numbers, Sequence Databank Numbers and Major Concepts.
Produced by the Web Of Science group, Zoological Record is the world’s oldest continuing database of animal biology. It is considered the world’s leading taxonomic reference, and with coverage back to 1864, has long acted as the world’s unofficial register of animal names. The broad scope of coverage ranges from biodiversity and the environment to taxonomy and veterinary sciences.
Provides a simple way to search broadly for scholarly literature. Includes peer-reviewed papers, theses, books, abstracts and articles, from academic publishers, professsional societies, preprint repositories, universities and other scholarly organizations. Google Scholar sorts articles by weighing the full text of each article, the author, the publication in which the article appears, and how often the article has been cited in other scholarly literature, so that the most relevant results are returned on the first page.
Microsoft Academic is a project exploring how to assist human conducting scientific research by leveraging machine’s cognitive power in memory, computation, sensing, attention, and endurance. Re-launched in 2016, the tool features an entirely new data structure and search engine using semantic search technologies. The Academic Knowledge API offers information retrieval from the underlying database using REST endpoints for advanced research purposes.
The national library of the United Kingdom includes 150 million manuscripts, maps, newspapers, magazines, prints and drawings, music scores, and patents. Online catalogues, information and exhibitions can be found on its website. The library operates the world's largest document delivery service, providing millions of items a year to national and international customers.
The digital NSK portal is the central gathering place for the digital collections of the National and University Library (NSK) in Croatia. It was established in 2016 to provide access to the Library’s digital and digitized material collections regardless of storage location. The digital NSK portal enables a unified search of digitized material from the NSK Special Collections - books, visual material, maps and music material. From the end of 2019, all thematic portals are available independently: Digital Books, Digitized Manuscripts, Digitized Visual Materials, Digital Music Materials and Digitized Cartographic Materials (established in 2017). Currently available only in Croatian.
The official DOI (digital object identifier) link registration agency for scholarly and professional publications. Crossref operates a cross-publisher citation linking system that allows a researcher to click on a reference citation on one publisher’s platform and link directly to the cited content on another publisher’s platform, subject to the target publisher’s access control practices. This citation-linking network covers millions of articles and other content items from several hundred scholarly and professional publishers.
Dimensions is a next-generation linked research information system that makes it easier to find and access the most relevant information, analyze the academic and broader outcomes of research, and gather insights to inform future strategy. Dimensions delivers an array of search and discovery, analytical, and research management tools, all in a single platform. Developed in collaboration with over 100 leading research organizations around the world, it brings together over 128 million publications, grants, policy, data and metrics for the first time, enabling users to explore over 4 billion connections between them.
The primary aim of DOAB (Directory of Open Access Books) is to increase discoverability of Open Access books. Metadata will be harvestable in order to maximize dissemination, visibility and impact. Aggregators can integrate the records in their commercial services and libraries can integrate the directory into their online catalogues, helping scholars and students to discover the books.
OAPEN is dedicated to open access, peer-reviewed books. OAPEN operates two platforms, the OAPEN Library (www.oapen.org), a central repository for hosting and disseminating OA books, and the Directory of Open Access Books (DOAB, www.doabooks.org), a discovery service for OA books.
OpenAIRE aims at promoting and implementing the directives of the European Commission (EC) and the European Research Council on the promotion and funding of science and research. OpenAIRE supports the Open Access Mandate and the Open Research Data Pilot developed as part of the Horizon 2020 projects.
An integrated information service combining reference databases, subscription management, online journals, books and linking services. Widely used by libraries, schools, government institutions, medical institutions, corporations and others.
SFX® link resolver gives patrons and librarians a wealth of features that optimize management of and access to resources. It provides patrons with a direct route to electronic full-text records through OpenURL linking, delivers alternative links for further resource discovery, access to journals, and more. Released in 2001 as the first OpenURL resolver, SFX is continuously enhanced to support the newest industry developments and meet the evolving needs of customers. The records include a mix of scholarly material – primarily articles and e-books – but also conference proceedings, newspaper articles, and more.
A non-profit, membership, computer library service and research organization dedicated to the public purposes of furthering access to the world's information and reducing information costs. More than 41,555 libraries in 112 countries and territories around the world use OCLC services to locate, acquire, catalogue, lend and preserve library materials.
The world’s largest collection of open access research papers. CORE's mission is to aggregate all open access research outputs from repositories and journals worldwide and make them available to the public. In this way CORE facilitates free unrestricted access to research for all.
Since 2002, Research4Life has provided researchers at more than 10,500 institutions in over 125 lower and middle-income countries with free or low-cost online access to up 151,000 leading journals and books in the fields of health, agriculture, environment, applied sciences and legal information. There are five programs through which users can access content: Research for Health (Hinari), Research in Agriculture (AGORA), Research in the Environment (OARE), Research for Development and Innovation (ARDI) and Research for Global Justice (GOALI).
Perlego is a digital online library focusing on the delivery of academic, professional and non-fiction eBooks. It is a subscription-based service that offers users unlimited access to these texts for the duration of their subscription, however IntechOpen content integrated on the platform will always be available for free. They have been billed as “the Spotify for Textbooks” by the Evening Standard. Perlego is based in London but is available to users worldwide.
MyScienceWork provides a suite of data-driven solutions for research institutions, scientific publishers and private-sector R&D companies. MyScienceWork's comprehensive database includes more than 90 million scientific publications and 12 million patents.
CNKI (China National Knowledge Infrastructure) is a key national information construction project under the lead of Tsinghua University, and supported by PRC Ministry of Education, PRC Ministry of Science, Propaganda Department of the Communist Party of China and PRC General Administration of Press and Publication. CNKI has built a comprehensive China Integrated Knowledge Resources System, including journals, doctoral dissertations, masters' theses, proceedings, newspapers, yearbooks, statistical yearbooks, ebooks, patents, standards and so on. CNKI keeps integrating new contents and developing new products in 2 aspects: full-text academic resources, software on digitization and knowledge management. Began with academic journals, CNKI has become the largest and mostly-used academic online library in China.
As one of the largest digital content platform in China,independently developed by CNPIEC, CNPeReading positions herself as “One Platform,Vast Content, Global Services”. Through their new cooperation model and service philosophy, CNPeReading provides integrated promotion and marketing solutionsfor upstream publishers, one-stop, triune, recommendation, online reading and management servicesfor downstream institutions & libraries.
ERIC (Education Resources Information Center), sponsored by the Institute of Education Sciences (IES) of the U.S. Department of Education, provides access to education literature to support the use of educational research and information to improve practice in learning, teaching, educational decision-making, and research. The ERIC website is available to the public for searching more than one million citations going back to 1966.
The ACM Digital Library is a research, discovery and networking platform containing: The Full-Text Collection of all ACM publications, including journals, conference proceedings, technical magazines, newsletters and books. A collection of curated and hosted full-text publications from select publishers.
BASE (Bielefeld Academic Search Engine) is one of the world's most voluminous search sengines especially for academic web resources, e.g. journal articles, preprints, digital collections, images / videos or research data. BASE facilitates effective and targeted searches and retrieves high quality, academically relevant results. Other than search engines like Google or Bing BASE searches the deep web as well. The sources which are included in BASE are intellectually selected (by people from the BASE team) and reviewed. That's why data garbage and spam do not occur.
Zentralblatt MATH (zbMATH) is the world’s most comprehensive and longest-running abstracting and reviewing service in pure and applied mathematics. It is edited by the European Mathematical Society (EMS), the Heidelberg Academy of Sciences and Humanities and FIZ Karlsruhe. zbMATH provides easy access to bibliographic data, reviews and abstracts from all areas of pure mathematics as well as applications, in particular to natural sciences, computer science, economics and engineering. It also covers history and philosophy of mathematics and university education. All entries are classified according to the Mathematics Subject Classification Scheme (MSC 2020) and are equipped with keywords in order to characterize their particular content.
IDEAS is the largest bibliographic database dedicated to Economics and available freely on the Internet. Based on RePEc, it indexes over 3,100,000 items of research, including over 2,900,000 that can be downloaded in full text. RePEc (Research Papers in Economics) is a large volunteer effort to enhance the free dissemination of research in Economics which includes bibliographic metadata from over 2,000 participating archives, including all the major publishers and research outlets. IDEAS is just one of several services that use RePEc data.
As the authoritative source for chemical names, structures and CAS Registry Numbers®, the CAS substance collection, CAS REGISTRY®, serves as a universal standard for chemists worldwide. Covering advances in chemistry and related sciences over the last 150 years, the CAS content collection empowers researchers, business leaders, and information professionals around the world with immediate access to the reliable information they need to fuel innovation.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. 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He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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\r\n\tIn order to scientifically address significant issues such as climate change, which puts into question our very survival as a species, the current pandemic with its massive physical, socio-economical, and psychological consequences, and the rise of AI which challenges our established economic structures, we need to ask insightful questions: What is truly human? How can humans develop further? The answers to these questions are necessary not only to find new solutions to the current challenges, but also to shape new visions of what can come next.
\r\n
\r\n\tNeuroscientific research linking brain functions has produced a perspective on human development that includes normal, impaired, and enhanced neurophysiological, emotional and cognitive functioning. Human development has been considered the very aim of education and of educative processes. Indeed, the capabilities built through educational training are included in the UN’s human development index, according to which such capabilities are the ultimate criteria to assess the development of a country, rather than economic growth alone. Yet a full understanding of what Human Development truly constitutes, remains open. For example, tackling the question of what distinguishes human beings from other animals, and what humans’ possible development trajectory might look like, calls for a multidisciplinary approach. Consequently, contributions to such an inquiry might come from very different scientific fields, ranging from cognitive neuroscience to socioeconomics. For instance, in the field of neuroscience, self-awareness—the most specific characteristic of human beings—has been investigated in connection with its neural correlates. Recent research points to self-awareness as the particular ability of our species, directly connecting it to our abstract thinking which in turn enables envisioning new possible futures and self-development
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\r\n\tTo achieve a broad, multidisciplinary perspective on possible human development, subjects will be considered through varied— yet related—approaches. We will provide a complex yet consistent framework through which we will explore a substantial amount and variety of theories and case studies. Our ultimate goal will be to produce useful indications for policy making in diverse contexts, assist teachers and parents with child development in an optimal way, and enhance theoretical and practical knowledge.
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