\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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During his Fulbright experience, he also worked at the Hospital of University of Pennsylvania (HUP), Philadelphia and St Joseph’s Hospital, Chicago, USA with sub-specialty interest in rhinology and aesthetic nasal surgery. Dr BS Gendeh retired after 38 years government service as a consultant ENT surgeon at the National University of Malaysia Medical Centre (UKMMC) in 2014, and presently is a Visiting Professor at the Department of Otorhinolaryngology-Head and Neck Surgery at UKMMC and is a resident ENT consultant at Pantai Hospital Kuala Lumpur since 2014. Is an executive member of numerous National and International bodies including Board Chairman of Malaysian American Commission on Educational Exchange (MACEE) from 2013-2015. Due to his vast contribution to the academia in research and clinical publication, he was elected as a Diploma of Fellowship Academy of Medicine Malaysia (FAMM) in October 2000, International Fellow of the Academy of Otolaryngology Head and Neck Surgery in April 2004, Fellow of the Academy of Sciences Malaysia (FASc) in April 2016 and as Fellow of Malaysian Scientific Association (FMSA) in September 2017. He has written 96 scientific papers with more than 550 citations and editor/co-editor of 8 books and 37 book chapters an H index of 15.",institutionString:"Pantai Hospital Kuala Lumpur",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"4",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247041",firstName:"Dolores",lastName:"Kuzelj",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247041/images/7108_n.jpg",email:"dolores@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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However, these difficulties can be generally grouped in relation to mechanism/structural design, actuation selection, and perception. All three fields are affected by the fact that the room for passage, navigation, and operation is very limited. In addition to restrictions in the size of the device, the interaction between the medical device and the tissues or blood poses deeper questions regarding the accuracy of the control and safety of the patient. Regarding the robotic endoscopes/catheters, they can be used as diagnosis tasks using deliberate palpation as well. The other two obvious tasks could include safe navigation inside a narrow and torturous channel while providing adequate accuracy and stiffness at the location of the operation. This chapter presents three different novel approaches which can provide feasible solution to the design challenges while improving the safety. First, in order to improve the mechanical structure and mobility, hyper-redundant mechanisms are presented in Section 2 featuring three different module designs, emphasizing the reconfigurability and modularity. Then, for providing the adjustable forces and compliant action, variable actuator mechanisms are visited in Section 3. The last innovation path involves the perception upgrade, detailing on tactile sensors in Section 4. Involving the tactile sensing units in the robotic skin or sheath can help obtain better feedback and more accurate diagnosis and/or provide safer operation when there are obstacles in the path. All these three aspects are summarized in \nFigure 1\n.
\nAn endoscopic robotic platform performing diagnosis, navigation, and operation having a hyper-redundant structure, featured in [
Modern surgical robots have been designed and implemented to help surgeons in operations requiring high dexterity and minimal invasiveness. Although great versatility and control have been realized using large, rigid, and serial-link robots such as Da Vinci, catheter-type robotic platforms having smaller dimensions can present an alternative and less expensive solution especially for minimally invasive surgery [3].
\nIn conventional medical use, catheters are manually controlled devices for diagnosis, drug delivery, and basic operations which do not require intricate motion patterns or application of a well-controlled force on the surgical site. Catheters often have a tendon-driven guidewire and a sheath to cover the guiding mechanism which may or may not feature a surgical head/clipper or a micro-mechanism to operate on sensitive tissues. Although originally being passive medical devices, the catheters can be re-designed to gain features such as multiple degrees of freedom, mobility, controllability, and perception. With these improvements in their structure, the catheters can become autonomous or semi-autonomous surgical platforms which can travel in difficult passages in the human body without harming the inner tissues and help the operation itself to be more successful with superior position and force control.
\nMost of the hyper-redundant or piecewise continuum structures still use rigid or semirigid backbones or general frames. Recently proposed hyper-redundant modular structures can be found in [4, 5, 6]. In [4], high dexterity and stiffness requirements are met, whereas the design has poor flexibility, limited compliance, and intricate mechanical structure which can be difficult to miniaturize for medical applications. Other prototypes can feature stiffness control [5] but may fall short in module-based controllability. It is even possible to see applications with better control [6] featuring continuum elastic backbone while segmenting the structure into modules using coupling plates; however, the size and compactness criteria are not fulfilled. The cable-driven structures are lightweight and compact, but there is an inherent limitation of such mechanisms due to cable friction and interdependency between the sections of the modules. As the limitations and drawbacks of such mechanisms are given, in the next section the advantages are highlighted to draw attention to their potential in medical robotics.
\nThe main idea of a hyper-redundant robotic platform with a modular building block is to increase the controllability and maneuverability of the robot. Increasing the number of DOF seems to be the main advantage; however, it is surpassed by the fully continuous robot (i.e., tubular/telescopic pre-curved continuum robots) that can be manipulated in 3D space without the need of complicated inverse kinematic calculations due to their inherent compliancy. Although fully continuum robotic platforms have this advantage, for most of the cases, the segment-based local control is not possible to obtain, and in most of the continuum prototypes despite their inherent compliancy, the stiffness control is not possible. Therefore, in this section, we would like to highlight the modular hyper-redundant robotic designs that can offer segment-based position control as well as adjustable stiffness. When the robotic catheter has both the position and the stiffness control, the navigation of the robotic catheter inside the torturous channels becomes an optimal control problem where the position and force are controlled with varying priorities according to the path planning and the operation task. This greatly increases the inherent safety of the robotic catheter. In the following section, designed mechanism modules are introduced and compared using workspace and stiffness analysis.
\nA recent hyper-redundant manipulator can be found in [7] which has electromagnetically actuated manipulator. Early examples of hyper-redundant manipulators with full solution on kinematics and dynamics are given in [8, 9, 10]. However, control algorithms suggested for such mechanisms are still in progress. For example, a modular control scheme is proposed in [11].
\nIn this section, the design of hyper-redundant and modular robotic structures is detailed by emphasizing the functional properties such as independent module/segment controllability and variable-adjustable stiffness. The proposed designs [12] are aimed at improving both position and force control of such structures employing whole-body shape control and local stiffness control in the robotic catheter. Three different module designs for hyper-redundant mechanisms are depicted in \nFigure 2\n. The first mechanism is called “hybrid” and essentially a universal joint placed in between two parallel plates and supported by a concentric shaft. This mechanism has three DOF per module, having pan and tilt for adjusting the heading angle while using the translational movement to shrink or elongate while adjusting its stiffness.
\nModules for hyper-redundant backbone construction, from left to right: Hybrid module, radially reconfigurable 3x SPS parallel kinematic mechanism, and seahorse tail section, featured in [
The second mechanism is 3x SPS having spherical-prismatic-spherical joints in each strut and is essentially a reconfigurable parallel mechanism. This mechanism provides stiffness adjustments by relocating the connection points of the struts on the lower plate. The struts can also elongate and contract along their axis so that the hyper-redundant platform can be adjusted when passing along difficult cavities.
\nFinally, the last module is named after the seahorse tail since it is inspired by the cross section of the biological counterpart. This mechanism can radially contract and widen to mimic the function of oblique muscles in seahorse tail structure. The modules are connected by a spherical joint in the middle. Since the radial struts are spring-loaded, the radial stiffness can be adjusted.
\nThe main advantage of hyper-redundant mechanisms is that each segment can be controlled separately, and the multi-degree-of-freedom makes it possible to control the whole-body shape of the manipulator to reduce the risk of harming the tissues during the navigation task. If the modules also have variable stiffness or re-configurability as it is shown here, the versatility and the safety of the hyper-redundant platforms increase. Since robotic platforms should accomplish tasks such as navigation, diagnosis, and operation, they may have to support different levels of stiffness when required. This type of adjustability can be achieved via special actuators as well. The next section expands on this view by supporting these mechanisms with variable stiffness actuators.
\nRehabilitation is known as the process of regaining the deceived somatic talents as a result of an illness or accident, all of which are necessary for survival, quality of life, and living together with their families and society. With the advancement of technological development, specialized mechanisms and devices are used more frequently to resolve some of the issues related with physical interaction between humans and robots. Also these mechanisms or devices operate in clinical environments; some of them are designed to provide mobility for daily usage. Namely, exoskeletons are the wearable types of these mechanisms. Among military usage, civilian purposes, and industrial applications, exoskeletons are for rehabilitation or acquisition of lost actions of people with disabilities. Commonly, similar to other mechatronic systems, exoskeletons comprise sensing, control, and actuation components.
\nSince rehabilitation is a human-centered therapy to overcome the impairments of the motor functions, it is required to be for exoskeletons to provide safe interaction and mimicking human motions [13]. Compliance is a prerequisite for safety, which can be maintained by software or hardware solutions. Software-based solutions allow controlling impedance [14] by implementing control techniques on rigid joint structures [15]. On the other hand, hardware-based solutions imply flexible joint structures with passive compliance [16, 17]. Also, the interface surface between the patient and the mechanism is covered by soft materials to increase comfort. In addition, adequate amount of force/torque should be supplied to perform the predefined tasks successfully while maintaining a lightweight mechanical structure [18].
\nSafety is a trending topic within industrial robotic applications. To increase precision, robot joints are designed as stiff as possible; however, Pratt et al. [19] proposed to connect motor and load with elastic components. Consequently, passive compliance is obtained, but it is comprehended that single stiffness value is not suitable for different robotic tasks. Variable stiffness actuators (VSAs) or in general variable impedance actuators (VIAs) are able to adjust the stiffness/impedance within a specific range (see \nFigure 3\n).
\nSchematic representation of series elastic actuators (SEA) or variable stiffness actuators (VSA).
Besides the need of excessive number of human therapists for ordinary rehabilitation techniques, they are time-consuming for labors [20]. Furthermore, these techniques are deficient to measure the performance of rehabilitation outputs for objective analysis. Inflexibility due to different level of treatments, namely, impersonal aims, can be counted as another drawback for traditional rehabilitation therapy methods. In this section, VSA-based exoskeleton/rehabilitation mechanisms are presented as possible solutions to these problems.
\nConventional robot joints are designed to track a motion profile and try to keep the position against external effects after reaching the goal position. On the contrary, in the SEA mechanism, there are elastic elements between the load and the motor, which allow the external influences to change in the joint position. The elastic element herein has constant output stiffness (k), and the relation between torque (τ) and position (θ) is linear as follows:
\nwhere Δθ denotes the deflection of the elastic element. VSA mechanisms are designed to have nonlinear τ-θ relation yielding variable output stiffness as given in Eq. 3:
\nwhere f(θ) is the nonlinear stiffness function. Regarding the change in stiffness, the reaction of the joint for external effects can be adjusted according to the desired task. The stiffness adjustment mechanisms are classified in three main categories in [21]: (i) spring preload, (ii) changing transmission between load and spring, and (iii) physical properties of the spring. The system, in which a couple of springs and motors run in a reciprocal manner, namely, antagonistic springs, is the first type. The working principle resembles biological musculoskeletal system in the first category. To obtain a linear stiffness variation, two quadratic springs are utilized in [22] by using a cam mechanism with a linear helical spring. In [23], the importance of quadratic springs in the design of VSAs is shown. The second type provides nonlinear torque-position relation by changing the distance between rotation center, the linear spring connection points, and/or tip point [24]. The last kind exploits natural characteristics of linear springs. In [25], nonlinearity of helical springs under bending and compression determines stiffness variation. Moreover, mechanism in [26] specifies the number of active coils of helical spring which results a change in stiffness. General schematic representations of the first two types are given in \nFigure 4\n.
\nStiffness adjustment types: (a) spring preload; (b) changing transmission between load and spring.
VSAs are generally actuated by conventional electrical motors; however, in [27] stiffness variation is obtained by a pneumatically artificial muscle. Hobby servo motors are another alternative to conventional motors which is used in a modular VSA design to lower the cost [28]. Similar to actuation units, elastic components can vary in different mechanisms. Although it is not implemented in an actuator, a nonlinear spring mechanism in [29] includes rubber, and in [30], a timing belt is introduced as the source of elasticity.
\nVSAs are superior to conventional actuators according to energy efficiency under various working conditions and performing highly dynamic task. Energy-efficient gait is performed by using compliant actuators because of the energy storage capability of the elastic element. However, when the environment or the walking speed is changed, natural dynamics of the mechanism is expected to maintain efficiency. In [31], running motion energy cost of a legged robot,
Modern studies towards medical mechatronic systems are performed as interdisciplinary collaboration conducted with physicians, therapists, and scientists among engineering community. Recent approach to these systems serves the emergence of new perspectives beyond the advantages of robot-assisted therapy. Principally, practical studies can be divided into two parts depending on the intention of mechanisms to the upper body and lower body.
\nUpper body exoskeleton applications are mostly focused on the upper limb and elbow parts. A torque-driven and lightweight exoskeleton called
Lower body assistance can be in forms of full support to the legs, or it can affect only dysfunctional part such as the ankle or knee. Exoskeletons and rehabilitation mechanisms are widely used in the lower limb to regain locomotion of disabled or patients who have difficulty with walking. In addition to gait assistance, standing up motion is provided with the help of exoskeletons. A brace about the foot which is called as ankle-foot orthosis (AFO) is a usual treatment for drop-foot gait. A variable impedance actuator with force and position sensors is assembled to an AFO in [36]. It is shown that during different phases of the gait, adjusting impedance values increases the benefits of AFOs. Sit-to-stand task is a torque demanding task especially for knee joints. In [37], a lever arm mechanism based on VSA for knee exoskeleton is presented, and design methodology is explained in detail. Moreover, the effects of different stiffness values are evaluated for standing task. It is not only necessary to supply sufficient torque to knee joint but also to understand the intention of the user. Instead of splitting task into phases to control stiffness or impedance in [28], muscle activity of the patient is collected via EMG in order to detect patient intention and correct stiffness values in [29]. Along with functional design of VSAs in rehabilitation mechanisms, researchers are inspired from the human muscle structure and designed full lower limb orthosis to improve impaired gait of patients by using pneumatic [38] and wire-based artificial muscles [20]. Furthermore, VSAs are expected to mimic human joint behaviors and have a great potential [39, 40] to be used in rehabilitation purposes. In [25] a VSA which resembles a human neck joint is presented. The schematic representation of the mechanism is given in \nFigure 5\n. Cable-driven lightweight structure brings simplicity. Also, there is no additional hardware other than a helical spring for stiffness variation. Although the middle shaft restricts the motion due to its revolute-revolute-prismatic (RRP) structure, actuation principle is similar to parallel mechanisms.
\nVariable stiffness neck joint. (a) Components of the mechanism and (b) reduced kinematic model [
All in all, robot-assisted rehabilitation studies and applications are still attractive research areas. Human motion imitation for mechanisms used in rehabilitation is emphasized for successful results. To this end, VSAs are comprised within rehabilitation systems. More information about the latest progress can be found in [41, 42, 43]. These findings reveal that robot-assisted technologies will result in less human labor time consumption with increasing quality of observable rehabilitation outputs.
\nFor connecting the robot to its environment, visual sensor channels are usually preferred and widely applied. The tactile sensor applications are limited to certain locations, which tends to be the tip of the device especially for robotic catheters. In this part of the chapter, a large-area application for the tactile sensors to form an artificial skin on the robotic catheter is covered. The large-area, skin-like applications of tactile sensors can empower the robotic catheters to have better perception output during diagnosis/palpation while helping to obtain higher safety levels during operations.
\nIn one of the recent surveys on state-of-the-art tactile sensing for minimally invasive surgery (MIS) [44], it is clearly stated that the best place to include sensing elements in MIS device is on the instrument shaft inside the patient’s body. The force sensors on the tip of the endoscopic tools are not strongly suggested, because the space is very limited. Incorporating a tip sensor involves either having a larger gripper or manufacturing of extremely small transducers. The general overviews on the tactile sensors without a specific focus on use in the surgical robotics can be seen in [45, 46, 47, 48]. In [46], the focus of the overview was extended to electronic skin technologies, whereas in [45] the effective utilization of the tactile skin takes the contact condition into special consideration. Some overviews focus on the wearable features [47], and the others explain the difficulties in the development of tactile sensor units emphasizing its complexity involving multiple transduction ways [48]. In order to develop tactile sleeves/sheaths for MIS endoscopic robotic platforms, a broader perspective of current tactile technology development is needed. Although the application is very different and does not contain any tactile modalities, in [49] a flexible and wearable skin for health monitoring interface is reported. These types of advanced skin patches can even be used for scheduled drug delivery [50]. Some of the relevant studies can be found from soft robotics literature. For example, in [51] a shape-tracking algorithm using polyvinylidene fluoride (PVDF)-based sensors on the hyper-flexible beams is used. Although the beam is in 2D, the proposed method can be extended to 3D providing a spatial ego-motion tracking for flexible endoscopic robots. The research [52] reports a discrete piezo-ceramic sensor array embedded in soft substrate, therefore offering a solution to accuracy problems in film-based piezo material but at the same time providing some compliance and stretchable behavior. Although the piezo-electric transduction is very widely used, there are also alternative methods based on optical modality. For example, in [53], a large-area sensor for pressure measurement was suggested using organic field-effect transistors (OFETs). Similarly, in [54] an optical principle is used to measure data through employing fiber Bragg grating and waveguides inside the compliant substrate material. The waveguide approach is also used in [55] but employing PDMS as the substrate this time.
\nHerein, an example application is presented from AvH Project, MEDICARE [1], together with the measurement methodology it uses. The manufacturing of the tactile sleeve is achieved using multiple layers of silicone substrate in an additive manner to embed the piezo sensors in the desired depth and location. The silicone substrate was selected as Eco-flex 00-10 because of its relatively easy vacuuming and curing procedures. In addition to these advantages, the mechanical properties of Eco-flex are very close to the human tissue, and it is relatively low-cost. The distance between pressure sensors is large in this setup; however, ideally, they can be arranged with 4 mm separation in each active cell. The data cables connecting the sensors to the data acquisition circuit are soldered carefully, and meandering shapes are given to the bare wires to prevent fractures within the substrate when the sleeve moves with the backbone. It must be stated that using off-the-shelf sensors limits the stretchability of the sensing areas; still, the sleeve remains flexible enough to be wrapped around a robotic backbone. The tactile sleeve is produced in a flat sheet (\nFigure 6a\n) having slanted edges and was connected to the backbone in cylindrical form (\nFigure 6b\n) in the second step. The slanted angles at the edges allowed connecting the sleeve without having a bulk on the connection line. As it can be seen in \nFigure 6\n, the silicone sleeve features a ripple structure on the outer surface. This structure is a first attempt to increase the perception capacity of embedded sensors using the structural computation.
\nRobotic sheath for endoscopic hyper-redundant platform developed in AvH project by Dr. Boyraz at Leibniz University of Hannover: (a) flat; (b) wrapped around the robotic platform, featured in [
The measurement methodology of the sleeve when the outer surface of the silicone sleeve contacts with a rough surface, the ripples would help create a high-frequency interpretation of the surface properties in the sensor output. Although being very simple, the surface ripple structures can be elaborated to include multiscale ripples in a fractal manner to interpret different surface structures having different frequency in the vibration pattern.
\nIn this chapter, three different enabling technologies at research frontiers have been discussed to support safe interactions between robots and humans in different fields of robotics, mainly focusing on service, medical, and rehabilitation areas. We provided an extensive overview of variable stiffness, hyper-redundancy, and smart-skin structures in application cases. All these structures are only some of the enablers for safe HRI, and future studies should concentrate on integrating them in service robotics for the full benefit. While the variable stiffness offers inherent compliance during interaction and adaptability of the structures, the hyper-redundancy may allow better controllability of available degrees of freedom. Finally, the smart robotic skins can provide crucial feedback for safer interactions. As a holistic approach to safe HRI, inherent or structural compliance, enhanced controllability, and improved tactile feedback can bring significant safety built in robotic structures. In future work, the robotics platform that can integrate all of them may even have synergistic effects of the combined subsystems as the tactile feedback may directly be linked to variable stiffness adjustment or reconfigure the active links in a hyper-redundant structure.
\nThis work has been partially funded by Alexander von Humboldt Foundation during the Experienced Researcher Fellowship project of Dr. Pinar Boyraz at Leibniz University of Hannover under the supervision of Prof. Tobias Ortmaier and Prof. Annika Raatz.
\nFrom the prehistoric ages, the animals have been an integrated part of human life. With the progression of time, the dependency on domestic animals has only increased. At the present time also the human civilization cannot be imagined without the animal products we are using every day. Currently, an enormous livestock population throughout the world is contributing in achieving the global food security. But, the rapid explosion of human population which is projected to be nearly 9.7 billion within 2050 has increased the demand for animal products. So, researches are being targeted toward getting more production from the animals. The major barriers toward this goal are the different diseases and scarcity of animal feed especially in undeveloped or developing countries. Among the several diseases, problems associated with animal reproduction have always been a matter of great concern for the animal producers. The female animals having a reproductive problem cannot be conceived and produce offspring. Besides, most importantly, it also shuts the door for milk production. The major reproductive issues include anestrus, repeat breeding, delayed estrus, different infections, etc. Among them the problem of anestrus has an incidence rate of 2.13–67.11% in the bovine population of a country like India which is the largest producer of milk [1]. Anestrus is a condition when there is absence of regular reproductive cyclicity in the female animal. Consequently, the animal becomes unproductive and causes a huge economical loss to the farmers or producers. So, it is very much important to address this problem with much care. Already, there are several established as well as developing methodologies which can induce estrus in anestrus animals. It encompasses practices like administration of hormone to the use of biostimulation. Besides inducing estrus, some technologies can also synchronize it according to the need. Synchronization of estrus can help in simplifying managemental practices as well as in some advanced technologies like embryo transfer, in vitro fertilization, cloning, etc. In this chapter we are going to discuss about the normal estrus cycle, the anestrus problem, and the methodologies developed by the researchers for induction and synchronization of estrus.
Estrus cycle can be defined as the rhythmic changes that occur in the reproductive system of a female animal starting from one estrus phase to another. The normal duration of estrus cycle is 21 days in cow, sow, and mare, 17 days in ewe, and 20 days in doe. The domestic animals can exhibit a single estrus cycle or more than one estrus cycle in a year. The canine species show only one cycle in its breeding season; hence they can be called the monestrous. Other species which come into estrus twice or more are termed polyestrous animals. Among them some species have estrus cycles in a particular season and defined as seasonal polyestrous. It includes goats, sheep, and horses. On the other hand, cattle undergo estrus throughout the year. The seasonal polyestrous animals are greatly regulated by the photoperiod of the season for their reproductive activity.
The estrus cycle can be grossly divided into two phases, that is, follicular phase and luteal phase. The main event occurring in follicular phase is the development of the ovarian follicles, whereas in luteal phase there is formation and growth of the corpus luteum (CL). The follicular phase is again consisting of proestrus and estrus. The proestrus lasts for 3–4 days and the estrus phase only for 12–18 hours. FSH (follicle-stimulating hormone) is the principal hormone controlling the follicular phase. It causes enlargement of the follicles, increase in estrogen secretion from the granulosa cells of the ovary, and increase in the vascularity of the female reproductive tract. After the proestrus phase, there is a rapid increase in the luteinizing hormone (LH) level known as LH surge. This surge is responsible for the ovulation of the matured graafian follicle. In cattle, ovulation generally occurs 12 hours after the end of the estrus. At estrus phase, the animal shows the signs of estrus or heat. It includes mucous discharge from the vagina, restlessness, frequent micturition, bellowing, swelling of the vulva, etc. The animal tries to mount other animals and also stands to be mounted by other animals called as standing heat. After the estrus phase, the ruptured follicle starts to convert into corpus luteum and the animal enters into luteal phase. This phase is also divided into metestrus and diestrus. The duration of metestrus is 3–4 days, whereas diestrus can last from 10 to 14 days. In metestrus the estrogen level starts decreasing and progesterone increases. Though ovulation occurs in metestrus phase in cattle, it happens in the last portion of estrus phase in other domestic species like sheep, goat, horse, etc. The uterine contraction subsides and endometrial glands start growing in metestrus. The progesterone level continues increasing in diestrus and achieves a peak on 13–14 days after estrus phase. Afterward the size of the corpus luteum also starts decreasing, and the follicle grows if the animal is not pregnant. In the case of pregnant animals, the CL does not regress and secrete progesterone throughout the gestation period. If the animal is not conceived, the CL is destroyed after the end of this phase, and the animal enters into the follicular phase.
FSH and LH are the two gonadotropins majorly responsible for the events in estrus cycle. These are secreted from the anterior pituitary upon the stimulation of gonadotropin-releasing hormone (GnRH). GnRH that resides on the top of hypothalamo-pituitary-gonadal (HPG) axis controls the reproductive activities of the animals. The FSH and LH eventually act on the gonads and secrete sex steroids like estrogen and progesterone in female and testosterone in male. Estrogen and testosterone help in the development of secondary sexual characters in females and males, respectively. The secretion of GnRH depends upon different internal and external signals. For example, leptin secreted from the adipose tissue and melatonin from the pineal gland have a clear effect on the GnRH release. It is also stimulated by kisspeptin, a neuropeptide secreted from preoptic and arcuate nucleus of hypothalamus. So, any physiological or pathological condition which disturbs the release of GnRH can affect the normal reproductive behavior of the animals. The overall hormonal balance is very much essential for maintaining estrus cyclicity.
Anestrus is the lack of estrus or heat syndromes in female animals. It can be observed in heifers as well as cow. A good number of post-parturient cows show anestrus. Anestrus can be caused by different reasons and can be classified into different ways. Kumar et al. [1] have divided anestrus into two major parts based on the causes, that is, physiological anestrus and pathological causes of anestrus (Figure 1).
Classification of anestrus [
Physiological anestrus can be either ovulatory or anovulatory. Ovulatory anestrus is seen during gestation period of the animal. Anovulatory anestrus can be prepubertal, lactational, or postpartum. The animals before coming into puberty show follicular growth, but they cannot mature. Due to the action of FSH, the follicle develops up to the stage of theca internal but thereafter starts degrading. The LH pulse frequency is also low, and the threshold for the positive feedback of estradiol on LH surge is also very high [1]. So, there is no ovulation and no estrus. Gestational anestrus is common in all the animals. As there is a persistent corpus luteum present in the ovary throughout the gestation period, there is always an elevated level of progesterone. Progesterone has a negative effect on GnRH secretion and cyclicity stops. Though sometimes, cattle and buffalo can show estrus in the first few months of gestation. It is called gestational anestrus. The signs of estrus are indifferent from the nonpregnant animals in estrus, but the duration is shorter [2]. These animals also exhibit standing heat. The estrus should be carefully differentiated from true estrus to avoid undesirable effect on pregnant animals. At the end of gestation period, there is a decrease in progesterone level. Still the animals are unable to come into estrus cycle, known as postpartum anestrus. This anestrus provides some time for involution of the uterus so that animals can come into estrus subsequently. But, this duration should not be prolonged. Many times, due to lack of proper nutrition and several postpartum diseases, the animals do not show estrus. Proper care and management in the periparturient period can solve this issue. It is ideal to conceive the animal within 2 months of parturition to get one calf each year. When the animals are in lactation also, the estrus cycle can be disturbed especially in high yielders. A high level of prolactin hormone required for the milk synthesis can suppress the GnRH level. This is termed as lactational anestrus.
Pathological causes of anestrus can again be of two types, that is, congenital and hereditary causes of anestrus and acquired anestrus. Congenital and hereditary causes are observed in ovarian aplasia, ovarian hypoplasia, and freemartin. Acquired anestrus can be ovulatory or anovulatory. Examples of ovulatory acquired anestrus are subestrus, unobserved estrus, and persistent corpus luteum. Acquired anovulatory anestrus has been classified into three type (I, II, and III) based on the stage of follicular growth [1]. In the case of type I, the follicles grow up to four millimeters and start regressing. In type II, the follicles grow further up to deviation and preovulatory stage but regress thereafter, and the next follicular wave starts. In type III, the follicle reaches up to the dominant stage but fails to ovulate and converts into persistent follicle.
The problem of anestrus causes a huge economical loss to the farmers or producers. So, it needs to be solved immediately. Kumar et al. [1] have beautifully classified different ways of estrus induction. The estrus inducers can grossly be divided into two parts, that is, non-hormonal and hormonal. Non-hormonal treatments include plant-derived heat inducers, mineral supplementation, uterine and ovarian massage, and use of Lugol’s iodine. The hormones that are used in estrus induction are estrogen, progesterone, GnRH, prostaglandin, insulin, and anti-prolactin-based treatment. All these treatment procedures are described below.
Different plant extracts are being used for the treatment of anestrus traditionally. Several estrus-inducing herbal medicines are available in Indian market. The efficacy of estrus-inducing preparations like Prajana, Janova, Estrona, and Sajani is well established [3]. Other examples include Aloes, Heat-Up, Fertivet, Heat-raj, etc. These can be applied in delayed puberty, postpartum anestrus, and other problems. Though they can induce estrus in crossbred cows, the conception rate is remained unchanged.
Minerals have an important role in the reproduction of domestic animals, and their deficiency can cause several reproductive disorders. Deficiency of calcium is very common in postpartum cattle. Any alteration in Ca:P ration can affect the pituitary secretion and subsequently ovarian function [8]. This can cause delayed puberty, irregular estrus, etc. The optimum ratio of Ca:P should be within 1.5:1–2.5:1. Excess calcium is also harmful as it can disturb the absorption of other minerals. Phosphorus is a very important mineral for the normal reproduction. In the case of phosphorus deficiency, several disorders can be observed like delayed maturity, low conception rate, inactive ovary, etc. [8]. There are reports of other reproductive problems in areas with phosphorus deficiency. It includes silent estrus, delayed puberty, irregular estrus, and long inter-calving period [9]. Sodium and potassium are also necessary for maintaining normal reproductive physiology and energy metabolism, though excess consumption of potassium can cause a problem. Other trace minerals like zinc, selenium, cobalt, iodine, chromium, etc. also have a prominent role in the reproduction of domestic animals. Animals can come into anestrus if proper nutrition is not provided. So, feeding management should be the first approach to prevent the problem of anestrus. Minerals should be supplemented in optimum quantity. The use of area-specific mineral mixture should be encouraged.
It is the most economical method for the treatment of anestrus. In this method, gentle massage of the uterus and ovary is done perrectally. There are reports which state about its utilization in estrus induction. There is no clear mechanism of action of this method. Possibly, it can be attributed to increased blood circulation on the surface of the ovary and stimulation of ovarian intrinsic factors [10, 11]. Application of this method needs experts who have a good idea about the anatomy of female reproductive system.
Intrauterine application of Lugol’s iodine can effectively induce estrus in cattle, buffalo, etc. [12, 13]. A dose of 20–30 ml is sufficient for treatment. It also shows a good conception rate with cost-effectiveness. It actually acts as uterine irritant and increases blood supply there. It can also stimulate the hypothalamus for the secretion of GnRH, and thus the reproductive cycle is regained [13].
Estrogen is a very important hormone for the reproductive cycle of the animals. Administration of estrogen can help the animal to come into estrus [1], though it may be ovulatory or anovulatory. If a dominant follicle is present in the ovary, there will be ovulation. If no dominant follicle is present, it can be anovulatory. Estrogen promotes the ovulation through LH surge as estrogen shows a positive feedback effect toward the pituitary at this time. Use of estrogen is limited nowadays due to its side effects. Prolonged administration of estrogen can cause cystic ovary, peristalsis of the oviduct, etc. [1]. These can also lead to several infections like ovaritis, adhesion, etc.
Progesterone is secreted from the corpus luteum in a normal estrus cycle. With the decrease in the progesterone level, the follicles start growing. The same situation can be mimicked externally. Progesterone can be administered externally for a certain duration, and its withdrawal can cause induction of estrus. Several intravaginal progesterone-releasing devices are available. It includes CIDR (controlled internal drug release), PRID (progesterone-releasing intravaginal device), etc. Ear implant of progesterone is also available. These devices are generally used for 7–9 days and can be combined with other hormones like GnRH, prostaglandin F2α (PGF2α), etc. [1]. Other ways to use progesterone are oral progesterone compound and intramuscular injection.
GnRH and its analogues can be successfully used to induce estrus in animals. It induces ovulation, if mature follicle is present by inducing the LH surge. GnRH can improve conception at the timed artificial insemination (Al) after estrous synchronization with prostaglandin F2α [14]. GnRH given after PGF may enhance fertility through its direct or indirect (via LH secretion) action on the ovulatory follicle, and it may act in a similar fashion at insemination after spontaneous estrus [15]. Gonadotropin-releasing hormone improved fertility at first postpartum inseminations in some studies [15], but not all investigations [16]. Increasing progesterone after insemination may be one way to improve fertility in cattle. It is possible that LH released by GnRH could enhance fertility through its effects on luteal function [17].
For persistent corpus luteum and subestrus, PGF2α is the treatment of choice. Successful management of silent estrus in cattle and buffaloes can be done by the natural or synthetic analogue of PGF2α as a single dose with a reasonable degree [18, 19]. PGF2α is only effective between days 6 and 16 of the cycle and in the presence of active corpus luteum. Administration of 25 mg of natural PGF2α intramuscular or 250–500 μg of synthetic ones is required to regress the CL in both cattle and buffaloes [1]. Pursley et al. [20] described Ovsynch protocol may be used to treat subestrus or unobserved estrus.
Encouraging results have been found in the use of insulin for induction of estrus in animals either alone or in combination [21, 22, 23]. The recommended dose is 0.25 IU/kg body weight subcutaneously for 3–5 days. Promising results for management of anestrus in cattle have been observed with the use of GnRH or eCG pretreated with insulin [22, 23] and buffaloes [21, 24]. Insulin enhances the follicular growth in true anestrus buffalo which is a prerequisite for GnRH to be effective [24].
Summer anestrus in buffaloes could be due to hyperprolactinemia, with this assumption bromocriptine, an anti-prolactin drug [25], has been used. Melatonin is also known to suppress prolactin secretion [26]; however, melatonin has been reported as stimulator of both GnRH and gonadotrophin secretions in buffaloes. As the plasma concentration of melatonin is low during summer, induction of estrus and ovulation by using melatonin implants have been reported by Ghuman et al. [27] in all treated summer anestrus buffalo heifers; however, the time taken to induce estrus and ovulation was highly variable (4–36 days).
The manipulation of the estrous cycle or induction of estrus brings a large percentage of a group of females into estrus at a short, predetermined time [28]. One of the advanced managemental processes through which the humane errors and managemental costs could be minimized is synchronization of estrus. It is predominantly useful in sheep, where timely heat detection is difficult due to exhibitions of less external heat symptoms and also in large herd of cattle. It helps in fixing the breeding time within a short predefined period and thereby scheduling the parturition time at the most favorable season in which newborns can be reared in suitable environment with ample food for augmenting their survivability. As timely breeding of the animals is possible with this technique, fertility in farm animals may be expected toward the upper side. By improving the production efficiency of animals, estrus synchronization provides more economic returns to the owner.
Synchronization can shorten the breeding period to less than 5 days, instead of females being bred over a 21-day period, depending on the treatment regimen. Production of a uniform group of calves for the future replacement in the animal farm is another important benefit of this program. The current and future aspect of estrous synchronization is to focus on combining traditional methods of controlling cycle length with the follicular development manipulation. The combination of GnRH with the prostaglandin F2α [20]- and progesterone [29]-based synchronization program has shown a novel direction in the estrus synchronization of cattle with the follicular development manipulation.
To control the timing of the onset of estrus by controlling the length of the estrous cycle is the basic approach for the estrus synchronization. Various approaches for controlling cycle length are as follows:
Prostaglandin administration to regress the corpus luteum of the animal before the time of natural luteolysis
Progesterone or synthetic progestin administration to suppress ovarian activity temporarily
Creating estrous synchrony by using gonadotropin-releasing hormone or an analogue, which causes ovulation of a large follicle, helps in synchronizing estrous cycle in anestrous female.
Luteolytic agent such as prostaglandin F2α, or an analogue, which causes the regression of the corpus luteum can be used to synchronize estrus [30, 31]. Administration of PGF2α is only effective from 8 to 17 days of the estrous cycle when functional corpus luteum is available in one of the ovaries. Fertility is high after prostaglandin synchronization. Synchronization of estrus and fertility with this product are good in cyclic females but not in non-cycling cows.
One-shot prostaglandin: In this method a single injection of prostaglandin is given to cyclic females, and then these females are bred as they express estrus.
Two-shot prostaglandin: In this method two injections of prostaglandins are given at an interval of 10–14 days [32] once the stage of estrous cycle in the cows is unknown and detection of estrus is not required before or between injections.
High levels of progesterone in the female’s system are maintained with the help of progestogens [33], even after the regression of the corpus luteum. After the progestin removal, synchrony of estrus occurs up to 2–5 days. Melengestrol acetate (MGA) (oral feeding), Syncro-Mate-B (SMB) (ear implant), and CIDR (intravaginal device) are the commercial products which fall into this category. The longer the progestin was administered to cattle, the higher the rate of estrous synchronization, but the fertility of the synchronized animals was lower. Kaltenbach et al. [34] and Wiltbank [35] reported that the estradiol was luteolytic when administered early in the bovine estrous cycle. Combining progestin treatment and estradiol administration at the initiation enabled the period of progestin to be shortened (9–14 days) without reducing the percentage of animals exhibiting a synchronized estrus. This treatment regimen was the basis for the commercial products Syncro-Mate-B, PRID, and CIDR. Administration of progestin at “sub-luteal” levels demonstrated that it inhibits estrus and ovulation and synchronizes estrus in cattle, but that a persistent, estrogen-secreting follicle develops when progestin treatment extends the estrous cycle [36].
MGA feeding: MGA was added to feed such that females received 0.5 mg/head/day for 14 days and if MGA was administered, cyclic females begin to show estrus. This estrus was subfertile, and it was recommended that females should be bred on the second estrus following MGA removal [37].
Syncro-Mate-B (ear implant) treatment late in the estrous cycle (>14 days) in cow gives lower conception rates. The ideal time for SMB treatment to begin is between the 8th and 12th day of the estrous cycle to maximize estrus response.
Application of CIDR.
CIDR insert for cattle is made by molding a thin layer of silicon and progesterone mixture (10% w/w) around a nylon spine under high temperature. It contains 1.38 g progesterone and is designed to maintain higher blood concentrations of progesterone to at least 2 ng/ml for up to 10 days. The CIDR is easily inserted into the vagina and has good retention capacity (2.5% loss rate is normal); a flexible nylon tail is attached to it for easy removal. The CIDR provides an exogenous source of the progesterone, and its removal on treatment day 7 results in a rapid fall in plasma progesterone levels, which results in estrus synchronization in those animals responding to treatment.
Estrus synchronization and fertility with a combination of GnRH and prostaglandin F2α are good for cyclic females, and this combination may induce cyclicity in cows experiencing postpartum anestrus [20]. The new methods of estrus synchronization more precisely and control the time of ovulation more exactly in order to allow a single, timed insemination without the need for detection of behavioral estrus. Administration of GnRH during the estrous cycle in bovines causes regression or ovulation of the dominant follicle and initiates the emergence of a new wave of follicular growth [20]. Ovsynch, CO-Synch, Select-Synch, and Hybrid-Synch are the four systems for synchronization of estrus with GnRH-PG combinations.
At day 1 GnRH injection is used to program follicle growth in cyclic females and to induce ovulation in anestrous females, and PGF2α on day 8 induces regression of CL that is present to cause a decline in progesterone. Then on days 10–11, the second GnRH is given which induces ovulation of dominant follicles that have been preprogrammed by the first GnRH treatment. The major GnRH programs that do not involve use of the CIDR are described as follows:
GnRH-PGF system: This represents the simplest GnRH-based system. A common name for this system is “Select-Synch.” In this system a single dose of GnRH and prostaglandin was injected on day 1 and day 8, respectively. Some cows (8%) exhibit estrus up to 48 hours before PGF (day 6). The early estrous are fertile and cows can be inseminated 12 hours after detection. The peak estrous response occurs 2–3 days after PGF with a range of 1–5 days. With this system, a minimum of 5 days of estrous detection after PGF and 2 days prior PGF is required to detect most heats.
GnRH-PGF + GnRH system: This system is a GnRH-PGF system in which second GnRH injection is given to all or some cows between 48 and 72 hours after PGF (days 2–3), with timed AI on all or a portion of the herd.
In Ovsynch program, an injection of GnRH on day 1, an injection of prostaglandin on day 8, a second injection of GnRH on day 10, and then a timed insemination on day 11 are given [20]. The first GnRH injection alters follicular growth by inducing ovulation of the dominant follicle in the ovaries after the GnRH injection to form a new or additional CL [20]. Thus, estrus usually does not occur until a PGF2α injection regresses the natural CL and the secondary CL which is formed from the follicle induced to ovulate by the first GnRH injection. Based on transrectal ultrasonographic evidence, a new group of follicles appear in the ovaries, within 1–2 days after the first injection of GnRH [38]. From those follicles, a newly developed dominant follicle emerges, matures, and can ovulate after estrus is induced by PGF2α, or it can be induced to ovulate after a second GnRH injection. This GnRH release luteinizing hormone, the natural ovulation-inducing hormone of the estrous cycle. The stage of the estrous cycle when Ovsynch was initiated also affects synchronization and conception rate [38]. Ravi Kumar and Asokan [39] reported higher conception rate in subestrus buffaloes initiating the treatment with Ovsynch during the later stages of estrous cycle, but conception rate was nil in anestrus buffaloes though incidence of cyclicity was observed due to the treatment. Benefits of this program are as follows: there is tight synchronization of estrus, most females respond to the program, and it boosts estrus in non-cycling cows that are at least 30 days postpartum.
In CO-Synch program, an injection of GnRH on day 1, an injection of prostaglandin on day 8, and then a second injection of GnRH with breeding on day 10 are given. The benefits are as follows: there is tight synchronization of estrus, most females respond to the program, and it boosts estrus in non-cycling cows that are at least 30 days postpartum.
The Hybrid-Synch program is applied with an injection of GnRH on day 1, an injection of prostaglandin on day 8, and then estrous detection and breeding from day 8 to 11. Second injection of GnRH was given to the females which were not observed in estrus from day 8 to 11 and were bred on day 11. Hybrid-Synch program has a lower cost and less handling compared with Ovsynch and CO-Synch but more than Select-Synch. The program appears to have the highest conception rates among all GnRH-prostaglandin programs.
c. Progesterone in combination with GnRH-PG:
Oral administration of MGA to the cows for 14 days is performed, and 10 days after the withdrawal of MGA, GnRH injection was given. PGF2α is given after 7 days of GnRH injection. Patterson et al. [29] reported that 80% of the cows showed estrus within 48–96 hours after PGF2α injection.
Failure to synchronize cyclic animals appropriately or to induce fertile ovulation potentially in anestrous females can have major effects on the success of a synchronization program. This CIDR to GnRH-based program has the potential to decrease losses in each of these areas. The most common use of this system comprises insertion of the CIDR on day 1 and its withdrawal on day 8. GnRH injection is given on the day of CIDR insertion and CIDR is kept in situ for 7 days. Injection of prostaglandin is given on the day of CIDR withdrawal, and then the second GnRH injection is given after 2 days of prostaglandin injection.
The primary advantage of inclusion of the CIDR in this program is that it guarantees that females will be exposed to progesterone during the period between day 1 and day 8. This progesterone exposure will result in normal (21 days) rather than short (10 days) cycles in earlier anestrous cows. Moreover, the withdrawal of a progestin has been demonstrated to induce onset of cycles in some anestrous females; the likelihood of an ovulation is enhanced. A second advantage to inclusion of the CIDR in this program is that the early heats (day 6 to day 9) that are inherent to these systems are prevented. The progesterone released by the CIDR will prevent estrus and ovulation between days 1 and 9.
In general management has a tremendous role in the reproduction of animals. Proper nutritional management of the herd is essential for successful implementation of several synchronization programs in both cows and heifers. Managemental procedures like timed insemination and calf removal have been reported to be useful for synchronization of estrus and may also be applied in most of the synchronization programs for better results. Usually conception rates on timed insemination are lower than for visual observation. However, this lower conception rate may be counterbalanced by the reduction in management from timed insemination. Suckling frequency of calves causes a hormonal response which inhibits return to estrus, which is evident in beef cows. Short-term calf removal combined with other forms of synchronization increases estrus synchrony and conception rates in cows. Even a 48-hour calf removal alone has been shown to cause synchrony and cyclicity in some cows. This procedure is suitable, but requires better management and good facilities to prevent separated cows and calves from rejoining with each other.
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\n\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
\n\n1. CONFERENCE PAPERS & PRESENTATIONS
\n\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\n\n2. NEWSPAPER & MAGAZINE ARTICLES
\n\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\n\n3. GREY LITERATURE
\n\nWhite papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\n\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\n\nFor more information on this policy please contact permissions@intechopen.com.
\n\nPolicy last updated: 2017-03-20
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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If the 2030 Agenda for sustainable development is to be achieved, sustainable waste management approaches must be an environmental and public health imperative deserving political priority. Current reasons for the poor management of waste in Africa, include, amongst others, weak organizational structures; lack of appropriate skills; inadequate budgets; weak legislation; lack of enforcement; low public awareness; corruption, conflict; political instability; and lack of political will. At the heart of the problem, is a failure in governance. However, through these gaps, many social and technological innovations have emerged. Innovations that recognize the opportunity that waste provides as a secondary resource. Diverting waste away from dumpsites and landfills towards reuse, recycling and recovery can improve the livelihoods of thousands of informal waste reclaimers, while also creating new jobs and business opportunities for the continent. Reintroducing secondary resources such as polymer, fiber, metals and nutrients back into local value chains has the potential to strengthen manufacturing economies and reduce the economic burden on product imports. Bringing waste under control in Africa and unlocking the opportunities that “waste” provides as “resource” will require immediate intervention by government, business and civil society.",book:{id:"8478",slug:"regional-development-in-africa",title:"Regional Development in Africa",fullTitle:"Regional Development in Africa"},signatures:"Linda Godfrey, Mohamed Tawfic Ahmed, Kidane Giday Gebremedhin, Jamidu H.Y. Katima, Suzan Oelofse, Oladele Osibanjo, Ulf Henning Richter and Arsène H. Yonli",authors:[{id:"58376",title:"Prof.",name:"Oladele",middleName:null,surname:"Osibanjo",slug:"oladele-osibanjo",fullName:"Oladele Osibanjo"},{id:"293145",title:"Prof.",name:"Linda",middleName:null,surname:"Godfrey",slug:"linda-godfrey",fullName:"Linda Godfrey"},{id:"304936",title:"Prof.",name:"Mohamed",middleName:null,surname:"Tawfic Ahmed",slug:"mohamed-tawfic-ahmed",fullName:"Mohamed Tawfic Ahmed"},{id:"304937",title:"Prof.",name:"Kidane",middleName:null,surname:"Giday Gebremedhin",slug:"kidane-giday-gebremedhin",fullName:"Kidane Giday Gebremedhin"},{id:"304938",title:"Prof.",name:"Jamidu H.Y.",middleName:null,surname:"Katima",slug:"jamidu-h.y.-katima",fullName:"Jamidu H.Y. 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Therefore, the increase in waste that was generated by the industrial factories and the human activities needs to be managed. For this reason, scientists have discovered new types of engineering that include sustainable engineering and green engineering to reduce energy and natural resource consumptions. The main goal of this chapter is to explain the main advantages of sustainable manufacturing process and their effects in minimizing or eliminating production and processing wastes through eco-efficient practices, and it encourages adopting new environmental technologies. Therefore, this chapter offers a short introduction about sustainability, sustainable manufacturing process, solid-state management, and two case studies that include experimental works for recycling plastic waste and nonferrous waste materials by using sustainable solid waste recycling process to reduce waste and eliminate its influence on the environment.",book:{id:"5704",slug:"skills-development-for-sustainable-manufacturing",title:"Skills Development for Sustainable Manufacturing",fullTitle:"Skills Development for Sustainable Manufacturing"},signatures:"Ahmad K. Jassim",authors:[{id:"195227",title:"Dr.",name:"Ahmad",middleName:"K",surname:"Jassim",slug:"ahmad-jassim",fullName:"Ahmad Jassim"}]},{id:"29275",doi:"10.5772/27624",title:"Sustainable Building in Malaysia: The Development of Sustainable Building Rating System",slug:"sustainable-building-in-malaysia-the-development-of-sustainable-building-rating-system",totalDownloads:9104,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"2015",slug:"sustainable-development-education-business-and-management-architecture-and-building-construction-agriculture-and-food-security",title:"Sustainable Development",fullTitle:"Sustainable Development - Education, Business and Management - Architecture and Building Construction - Agriculture and Food Security"},signatures:"Ar Zuhairuse MD Darus and Nor Atikah Hashim",authors:[{id:"70881",title:"Prof.",name:"Zuhairuse",middleName:null,surname:"Darus",slug:"zuhairuse-darus",fullName:"Zuhairuse Darus"},{id:"135807",title:"Ms.",name:"Nor Atikah",middleName:null,surname:"Hashim",slug:"nor-atikah-hashim",fullName:"Nor Atikah Hashim"}]},{id:"62818",doi:"10.5772/intechopen.79220",title:"Methodologies for Assessing Sustainability in Farming Systems",slug:"methodologies-for-assessing-sustainability-in-farming-systems",totalDownloads:1854,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"Development of composite indicators is considered an important approach for evaluating sustainable development. For agriculture, different indicators have been developed such as Delphi, IDEA, MESMIS, MOTIFS, RISE, or SAFE. For its construction, usually bivariate and multivariate statistical techniques were employed. These are pragmatic tools used to simplify the description of complex systems by the use of three functions: to simplify, to quantify, and to communicate easily. Criteria for indicator selection include policy relevance, validity, accessibility, and measurability. However, operational evaluation of agricultural sustainability presents problems, because it requires analyzing the future production of goods and services, which need to be observed on a reasonable time horizon, and other difficulties involve interpreting the combination of indicators required for such analyses. This chapter realizes a review of these methodologies and its applications.",book:{id:"6823",slug:"sustainability-assessment-and-reporting",title:"Sustainability Assessment and Reporting",fullTitle:"Sustainability Assessment and Reporting"},signatures:"Jaime Fabián Cruz, Yolanda Mena and Vicente Rodríguez-Estévez",authors:[{id:"101973",title:"Dr.",name:"Vicente",middleName:null,surname:"Rodríguez-Estévez",slug:"vicente-rodriguez-estevez",fullName:"Vicente Rodríguez-Estévez"},{id:"256388",title:"Dr.",name:"Yolanda",middleName:null,surname:"Mena",slug:"yolanda-mena",fullName:"Yolanda Mena"},{id:"256393",title:"Ph.D. Student",name:"Fabian",middleName:null,surname:"Cruz",slug:"fabian-cruz",fullName:"Fabian Cruz"}]}],mostDownloadedChaptersLast30Days:[{id:"67950",title:"The Factors Influencing SMEs Growth in Africa: A Case of SMEs in Zimbabwe",slug:"the-factors-influencing-smes-growth-in-africa-a-case-of-smes-in-zimbabwe",totalDownloads:2727,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Today Africa reports high levels of unemployment among other social issues causing governments’ instability and low economic growth. Brain drain, low gross domestic product (GDP) per capita and growth reported across the continent requires an initiative on driving entrepreneurship development. The study seeks to investigate the determinants of small to medium enterprises (SMEs) growth in developing countries with a special focus on Zimbabwe. Informed by literature, the Zimbabwe Finscope Business Consumer Survey (2012) data was used to run a linear programming model regression analysis on the factors influencing SMEs profitability in that country. The study found that number of business units, education level, business type, family run businesses, expertise, licenced, advertising and bank account were significant in influencing SMEs profitability. The results will assist policymakers, development partners, entrepreneurs and other stakeholders. The insight can also be useful to venture capitalists, investment banks, investors and other financiers. There is need to support the millions of SMEs and future entrepreneurs in improving the regulatory and business environment, improving institutional support systems, promoting technology transfers, innovations and improving productivity.",book:{id:"8478",slug:"regional-development-in-africa",title:"Regional Development in Africa",fullTitle:"Regional Development in Africa"},signatures:"Kosmas Njanike",authors:[{id:"292874",title:"Mr.",name:"Kosmas",middleName:null,surname:"Njanike",slug:"kosmas-njanike",fullName:"Kosmas Njanike"}]},{id:"56724",title:"Sustainable Solid Waste Recycling",slug:"sustainable-solid-waste-recycling",totalDownloads:2227,totalCrossrefCites:8,totalDimensionsCites:9,abstract:"Nowadays, overpopulation and rapid development of industries and lifestyle lead to an increase in the consumption of natural resources and reduction of their resource. On the other hand, humans have always produced waste and disposed it in some way, which influence the environment. Therefore, the increase in waste that was generated by the industrial factories and the human activities needs to be managed. For this reason, scientists have discovered new types of engineering that include sustainable engineering and green engineering to reduce energy and natural resource consumptions. The main goal of this chapter is to explain the main advantages of sustainable manufacturing process and their effects in minimizing or eliminating production and processing wastes through eco-efficient practices, and it encourages adopting new environmental technologies. Therefore, this chapter offers a short introduction about sustainability, sustainable manufacturing process, solid-state management, and two case studies that include experimental works for recycling plastic waste and nonferrous waste materials by using sustainable solid waste recycling process to reduce waste and eliminate its influence on the environment.",book:{id:"5704",slug:"skills-development-for-sustainable-manufacturing",title:"Skills Development for Sustainable Manufacturing",fullTitle:"Skills Development for Sustainable Manufacturing"},signatures:"Ahmad K. Jassim",authors:[{id:"195227",title:"Dr.",name:"Ahmad",middleName:"K",surname:"Jassim",slug:"ahmad-jassim",fullName:"Ahmad Jassim"}]},{id:"68270",title:"Solid Waste Management in Africa: Governance Failure or Development Opportunity?",slug:"solid-waste-management-in-africa-governance-failure-or-development-opportunity-",totalDownloads:1858,totalCrossrefCites:10,totalDimensionsCites:13,abstract:"Waste management is a social, economic, and environmental problem facing all African countries. If the 2030 Agenda for sustainable development is to be achieved, sustainable waste management approaches must be an environmental and public health imperative deserving political priority. Current reasons for the poor management of waste in Africa, include, amongst others, weak organizational structures; lack of appropriate skills; inadequate budgets; weak legislation; lack of enforcement; low public awareness; corruption, conflict; political instability; and lack of political will. At the heart of the problem, is a failure in governance. However, through these gaps, many social and technological innovations have emerged. Innovations that recognize the opportunity that waste provides as a secondary resource. Diverting waste away from dumpsites and landfills towards reuse, recycling and recovery can improve the livelihoods of thousands of informal waste reclaimers, while also creating new jobs and business opportunities for the continent. Reintroducing secondary resources such as polymer, fiber, metals and nutrients back into local value chains has the potential to strengthen manufacturing economies and reduce the economic burden on product imports. Bringing waste under control in Africa and unlocking the opportunities that “waste” provides as “resource” will require immediate intervention by government, business and civil society.",book:{id:"8478",slug:"regional-development-in-africa",title:"Regional Development in Africa",fullTitle:"Regional Development in Africa"},signatures:"Linda Godfrey, Mohamed Tawfic Ahmed, Kidane Giday Gebremedhin, Jamidu H.Y. Katima, Suzan Oelofse, Oladele Osibanjo, Ulf Henning Richter and Arsène H. 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Katima"},{id:"304939",title:"Prof.",name:"Suzan",middleName:null,surname:"Oelofse",slug:"suzan-oelofse",fullName:"Suzan Oelofse"},{id:"304940",title:"Prof.",name:"Ulf Henning",middleName:null,surname:"Richter",slug:"ulf-henning-richter",fullName:"Ulf Henning Richter"},{id:"304941",title:"Prof.",name:"Arsène H.",middleName:null,surname:"Yonli",slug:"arsene-h.-yonli",fullName:"Arsène H. Yonli"}]},{id:"73366",title:"Organizational Insights, Challenges and Impact of Sustainable Development in Developing and Developed Nations",slug:"organizational-insights-challenges-and-impact-of-sustainable-development-in-developing-and-developed",totalDownloads:806,totalCrossrefCites:0,totalDimensionsCites:3,abstract:"While developed nations can fully explore various sustainable business models to achieve sustainability, this might not be easy for developing nations because of poor governance systems, characterized by inequality, patronage, and corruption and other challenges. This chapter evaluates organizations as developing and developed nation blocs by first providing insights on how organizations can contribute to the social and environmental sustainability, and second, by highlighting the challenges and approaches for sustainable development. The chapter further unravels the potential for both blocs to grow and achieve sustainability through technology and innovative strategies alongside the opportunities offered by having fast-growing populations and natural resources. To achieve sustainability, a twofold approach comprising the 360-organizational sustainability approaches and advanced sustainability system analysis approach is used. The key societal driving forces in both blocs for exploiting sustainable business practices are governance and institutions, technology and innovation, economy and society, population and behavior, and financing for development which can unlock sustainable business opportunities for sustainable development. To address the business climate challenges, it is inferred that organizations can achieve global sustainability by integrating sustainable production and consumption, biodiversity and ecosystem services, equity and resilience sectors to attain an environmentally and socially governed systems globally.",book:{id:"10421",slug:"sustainable-organizations-models-applications-and-new-perspectives",title:"Sustainable Organizations",fullTitle:"Sustainable Organizations - Models, Applications, and New Perspectives"},signatures:"Katundu Imasiku",authors:[{id:"322704",title:"Dr.Ing.",name:"Katundu",middleName:null,surname:"Imasiku",slug:"katundu-imasiku",fullName:"Katundu Imasiku"}]},{id:"69489",title:"Sustainably Growing Guinea’s Bauxite-Aluminum Industry",slug:"sustainably-growing-guinea-s-bauxite-aluminum-industry",totalDownloads:932,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Guinea’s bauxite-aluminum industry is undergoing significant expansion of investment, concession agreements, and in-country mining and refining operations. In 2018, UNDP-Guinea and Columbia University developed a framework that would evaluate this development against metrics for social and environmental sustainability, such as energy access and diversification, water quality, land use, biodiversity restoration, waste management, and community engagement. Current environmental impacts measured in GHGs, a metric both economic and environmental, were compared to potential impacts anticipated as a consequence of expansion. These anticipated impacts include enormous increases in countrywide GHG emissions and significant regional shortfalls in access to electrical energy. Case studies from the international bauxite-aluminum industry were then used to illustrate best practices for climate mitigation and adaptation and to describe opportunities for regional collaboration on shared-use energy and infrastructure development (e.g., hydropower used across West Africa, rail transportation) while achieving measurable benefits to communities, NGOs, regulators, and mining companies.",book:{id:"8478",slug:"regional-development-in-africa",title:"Regional Development in Africa",fullTitle:"Regional Development in Africa"},signatures:"Lynnette Widder, Thomas D. 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His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,annualVolume:11970,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"20",type:"subseries",title:"Animal Nutrition",keywords:"Sustainable Animal Diets, Carbon Footprint, Meta Analyses",scope:"An essential part of animal production is nutrition. Animals need to receive a properly balanced diet. One of the new challenges we are now faced with is sustainable animal diets (STAND) that involve the 3 P’s (People, Planet, and Profitability). We must develop animal feed that does not compete with human food, use antibiotics, and explore new growth promoters options, such as plant extracts or compounds that promote feed efficiency (e.g., monensin, oils, enzymes, probiotics). These new feed options must also be environmentally friendly, reducing the Carbon footprint, CH4, N, and P emissions to the environment, with an adequate formulation of nutrients.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11416,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. 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