\r\n\tRisk management aims to develop an efficient organizational development environment through risk planning, assessment, analysis, and control. This process will apply in all areas of activity, and the evaluation framework is the same regardless of the field. This volume will aim to appeal to chapters that address methods, models, evaluation frameworks, benefits, barriers, and other dimensions of risk management. \r\n\tSustainability and the circular economy are approaches approached by many companies and have become activities of global interest. Protecting the environment, streamlining the consumption of organizational resources, reducing the amount of waste generated, and other activities are objectives of these efforts. The circular economy contributes to the sustainable development of the company or country and the achievement of the global objectives of sustainable development. This book will aim to collect various studies for organizational and global sustainability. \r\n\tLeadership has become a globally desirable approach that can help improve organizational competitiveness and reduce organizational risks. Risks and barriers in risk-free management can be well managed through effective organizational leadership. This book will aim to bring together chapters that explore different areas of leadership.
",isbn:"978-1-83768-218-8",printIsbn:"978-1-83769-991-9",pdfIsbn:"978-1-83768-219-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"5d9c14d51cb7e214a9093c454eab1404",bookSignature:"Prof. Larisa Ivascu, Dr. Ben-Oni Ardelean and Dr. Muddassar Sarfraz",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11937.jpg",keywords:"Technical Risk, Occupational Risk, Operational Risk Management, Economic Risk, Financial Risk, Thematic Mapping, Global Sustainability, Sustainability Models, Life Cycle Assessment, Critical Raw Materials, Global Leadership, Risks",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 5th 2022",dateEndSecondStepPublish:"June 2nd 2022",dateEndThirdStepPublish:"August 1st 2022",dateEndFourthStepPublish:"October 20th 2022",dateEndFifthStepPublish:"December 19th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Ivascu obtained Ph.D. in Management and graduated with an MBA in Production and Transportation from the Faculty of Management, Politehnica University of Timisoara. She is the president of the scientific committee of the Academy of Political Leadership and vice-president of the Society for Ergonomics and Work Environment Management. Dr. Ivascu has been involved in national and international projects and has published nine books, and contributed scientifically to more than 200 scientific articles.",coeditorOneBiosketch:"Dr. Ben-Oni Ardelean obtained Ph.D. in Political Science and Ph.D. in Theology; he has extensive academic and political experience. He is the author of several books and numerous academic articles. He is highly preoccupied with supporting those in need, helping others to help themselves, and motivating people to live a life of purpose, love, and compassion. Dr. Ardelean is also a researcher dedicated to the management area and an honorary member of the Academy of the Romanian Scientists.",coeditorTwoBiosketch:"Dr. Muddassar Sarfraz completed a postdoctoral fellowship in Business Management at the Business School of Hohai University, China. He is a member of the British Academy of Management, Chinese Economists Society (USA), World Economic Association (UK), and the American Economic Association. He is an ambassador of the MBA program at Chongqing University, China. His research focuses on corporate social responsibility, risk management, strategic management, and business management.",coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"288698",title:"Dr.",name:"Larisa",middleName:null,surname:"Ivascu",slug:"larisa-ivascu",fullName:"Larisa Ivascu",profilePictureURL:"https://mts.intechopen.com/storage/users/288698/images/system/288698.png",biography:"Dr. Larisa Ivascu is a professor at the Politehnica University of Timisoara, Romania, with eighteen years of experience in programming, teaching, and research. She graduated with an MBA in Production and Transportation from the Faculty of Management, Politehnica University of Timisoara. She is a doctoral supervisor in the field of engineering and management. She is the head of the Entrepreneurship Office of Politehnica University of Timișoara, and director of the Research Center in Engineering and Management. She is the president of the scientific committee of the Academy of Political Leadership, and vice-president of the Society for Ergonomics and Work Environment Management. Ms. Ivascu has been involved in national and international projects and has published nine books and contributed scientifically to more than 200 scientific articles.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}],coeditorOne:{id:"470825",title:"Dr.",name:"Ben-Oni",middleName:null,surname:"Ardelean",slug:"ben-oni-ardelean",fullName:"Ben-Oni Ardelean",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003SYylDQAT/Profile_Picture_2022-04-28T11:08:36.jpg",biography:null,institutionString:"University of Bucharest",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Bucharest",institutionURL:null,country:{name:"Romania"}}},coeditorTwo:{id:"260655",title:"Dr.",name:"Muddassar",middleName:null,surname:"Sarfraz",slug:"muddassar-sarfraz",fullName:"Muddassar Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/260655/images/system/260655.jpeg",biography:"Dr. Muddassar Sarfraz works as an assistant professor at Wuxi University, China. He completed a postdoctoral fellowship in Business Management at the Business School of Hohai University, China. He has published numerous papers in foreign authoritative journals and academic conferences at home and abroad. He is senior editor of Cogent Business & Management, associate editor of Frontiers in Psychology, Energies, and Future Business Journal, and guest editor of Frontiers in Environmental Sciences and INQUIRY. He is a member of the British Academy of Management, Chinese Economists Society (USA), World Economic Association (UK), and the American Economic Association, and an ambassador of the MBA program at Chongqing University, China. His research focuses on corporate social responsibility, risk management, strategic management, and business management.",institutionString:"Zhejiang Shuren University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Zhejiang Shuren University",institutionURL:null,country:{name:"China"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453622",firstName:"Tea",lastName:"Jurcic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"tea@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"70703",title:"Robust Nonlinear Control Strategy for Small Wind Turbines: A Case Study",doi:"10.5772/intechopen.90750",slug:"robust-nonlinear-control-strategy-for-small-wind-turbines-a-case-study",body:'\n
\n
1. Introduction
\n
During the last decade, the world has known a significant increase in electricity production from renewable energy sources, due in part to the liberalization of the electricity market, which has attracted the greed of new producers who are oriented towards cheaper productions (cogeneration, biomass, wind, etc.) and not in overly heavy investments (thermal power plants), and, secondly, because the emerging ecological awareness on climate change due to the emission of greenhouse gases has resulted in a political will that results from international protocols, such as Kyoto 1997 and Paris 2015, to encourage the use of clean and renewable energies for electricity generation [1].
\n
Currently, wind energy is an important part of renewable energy production. Based on statistics from the Global Wind Energy Council (GWEC), more than 50 GW of clean, emission-free wind power was installed in 2018, bringing total installations to 591 GW globally; those statistics forecast that the global installed capacity can reach more than 817 GW by 2021 [2]. However, as the wind energy is very different from conventional sources, it is an intermittent energy source that is not continuously available for conversion into electricity and outside direct control because the used primary energy cannot be stored, it may be predictable but cannot be dispatched to meet the demand of an electric power system. Thus, the rapid growth of wind energy penetration into power systems causes many problems regarding the power flow control flexibility, which has forced many countries to revise their grid codes to ensure stable and reliable network operation. Power systems can reach very high wind penetration levels, as is the case of Denmark (42.4%), Germany (14.8%) and Spain (14.1%) [3, 4].
\n
Nowadays the major challenge of the wind energy industry is to respect the deferent electrical grid requirements of each country; this means that power systems doest accept except a pure and balanced electrical energy comes from wind farms and in case of grid disturbances; those wind farms have to remain connected and support the grid to avoid black outs [5, 6]. As a result, the successful installation of wind turbines subject to requirements imposed by any country’s energy market will not be possible without the contribution of advanced and robust control strategies [7].
\n
Currently, wind turbine technology is almost based on two topologies: fixed speed-based topology (FST) which uses Induction Machines (IMs) and variable speed-based topology (VST) which generally uses Double Fed Induction Machines (DFIMs) or Permanent Magnet Synchronous Machines (PMSMs) [8].
\n
However, the FST topology is recognized by many advantages such as costless and no complexity even more, nevertheless it has many disadvantages such as lower efficiency; power fluctuations in the grid due to wind gusts, short life cycle due to significant efforts undergone by its structure [9]. Thus, even the wind system complexity will increase, but VST, in which power fluctuations could be reduced and hence wind gusts can be stored as kinetic energy in large rotating masses, has been proposed to mitigate all drawbacks of FST.
\n
In recent years, choosing the type of the electrical generator of WTs is a serious subject of several research works. This component represents the heart of a WT; it is used to produce electric power with lower cost and under variable nature of the wind speed. In the wind industry, two types of generators dominate the sector: (a) the Permanent Magnet Synchronous Generator (PMSG) with very low inertia, high volumetric torque, good efficiency and better controllability, which, furthermore, with the possibility to direct drive train, has become a serious competitor of (b) the Double Fed Induction Machines (DFIG). This latest (DFIG) is the most used in wind industry sector due to the ability to control powers flow with significantly improved yield. The DFIG can operate in different speed modes (sub-synchronous, synchronous and super-synchronous). Due to the progress of modern technologies, the use of the DFIG in large power scales seems to have become a more efficient solution for electrical energy generation whether for onshore or offshore installations [10, 11, 12].
\n
Therefore, developing robust nonlinear control algorithms for electro-mechanical systems actuated by different types of electric machinery, emphasizing system stability and robustness, is a very essential issue [13]. Under this scope, this chapter proposes a robust nonlinear control strategy based on Lyapunov Theory of a standalone Permanent Magnet Synchronous Generator (PMSM). Therefore, the chapter is focused on the design of nonlinear control strategy using the nonlinear feedback control techniques and Lyapunov theory to guarantee robustness of the wind energy conversion systems.
\n
Finally, based on simulation results, a general conclusion is presented in this chapter showing the performance of the proposed control strategy used for the studied wind turbine.
\n
\n
\n
2. Lyapunov theory and robust control association
\n
\n
2.1 Lyapunov theory fundamentals
\n
The theory introduced in the late 19th century by the Russian mathematician Alexandr Mikhailovich Lyapunov is generally the most useful approach for analyzing the stability and designing control of linear or nonlinear systems. In fact, Lyapunov’s work for stability problems includes two methods: the so-called linearization method and the direct method. The linearization method draws conclusions about a nonlinear system’s local stability around an equilibrium point from the stability properties of its linear approximation [14]. However, the direct method (or second method) is not restricted to local motion, and determines the stability properties of a nonlinear system by constructing a scalar “energy-like” function for the system and examining the function’s time variation [15]. In other words, the direct method is a generalization of the idea that if there is some “measure of energy” in a system, then we can study the rate of change of the system’s energy to ascertain stability [16]. In this chapter, we will focus on the direct method for the control scheme design.
\n
\n
2.1.1 Lyapunov’s direct method concept
\n
Lyapunov’s direct method for stability is now referred to as the Lyapunov stability criterion and makes use of a scalar “energy-like” function V(x), which has an analogy to the potential function of classical dynamics.
\n
It can be introduced for a system \n\n\nx\ṅ\n\n=\nf\n\nx\n\n\n having a point of equilibrium at \n\nx\n=\n0\n\n. Consider a function \n\nV\n\nx\n\n\n: \n\n\nR\nn\n\n→\nR\n\n such that
\n\n\nV\n\nx\n\n=\n0\n\n if and only if \n\nx\n=\n0\n\n. \n\nV\n\nx\n\n>\n0\n\n if and only if \n\nx\n≠\n0\n\n.
\n\n\n\nV\ṅ\n\n\nx\n\n=\n\nd\ndt\n\nV\n\nx\n\n=\n\n∑\n\ni\n=\n1\n\nn\n\n\n\n∂\nV\n\n\n∂\n\nx\ni\n\n\n\n\nf\ni\n\n\nx\n\n=\n∇\nV\n.\nf\n\nx\n\n≤\n0\n\n for all values of \n\nx\n≠\n0\n\n.
\n\n
For asymptotic stability, the condition \n\n\nV\ṅ\n\n\nx\n\n<\n0\n\n for \n\nx\n≠\n0\n\n is required.
\n
Then \n\nV\n\nx\n\n\n is called a Lyapunov function and the system is stable in the sense of Lyapunov.
\n
\n
\n
2.1.2 Stability of a linear system
\n
Consider a linear system described by its state space model as follows:
\n
\n\n\n\nX\ṅ\n\n=\nA\nX\n\n (A is a finite matrix), we can say that A is asymptotically (or exponentially) stable if all its eigenvalues’ real parts are negative; in other words, all the system states will converge to the vicinity of their equilibrium points [16].
\n
The above stability condition can be verified equivalently through Lyapunov concept, using the quadratic Lyapunov function as follows:
\n
\n\n\nV\n=\n\nX\nt\n\nPX\n\n with P is a symmetric positive definite matrix,
If \n\nX\n≠\n0\n→\n\nX\nt\n\nPX\n>\n0\n\n\n
then \n\n\nV\ṅ\n\n=\n\n\nX\ṅ\n\nt\n\nPX\n+\n\nX\nt\n\nP\n\nX\ṅ\n\n\n. Replacing the value of \n\n\nX\ṅ\n\n\n we have the following:
The stability condition is that \n\n\nV\ṅ\n\n<\n0\n\n so the matrix \n\nQ\n\n should be positive definite for some definite matrix \n\nP\n=\n\nP\nt\n\n\n [17].
\n
\n
\n
\n
2.2 Modeling of parametric uncertainty for AC machines
\n
\n
2.2.1 Resistance variation
\n
Heating of the machine windings due to temperature increase causes an increase in stator and rotor resistances. This variation can be generally presented in the following relation:
\n
\n\nR\n=\n\nR\n0\n\n\n\n1\n+\nαT\n\n\n\n
\n
where \n\nα\n\n is the temperature coefficient value (≈4.1 × 10−3) and T is the temperature in degree Celsius.
\n
\n
\n
2.2.2 Inductance variation
\n
The variation of the inductances is caused by the saturation of the ferromagnetic materials of the machine. The dynamics of this variation and that of currents cannot be considered slow [18].
\n
\n
\n
2.2.3 Skin effect
\n
This concerns the induction machine; in fact, the rotor bars’ resistance increases with the value of the frequency of rotor currents. An increase in the frequency causes a backflow of the currents to the periphery of the bars. The variation of the resistance of the bars is calculated numerically using a finite element method [18].
\n
In steady-state operation, that is to say in the absence of parametric disturbances, the machine parameters take nominal values.
\n
In general, the machine parameters are subject to unknown variations resulting from the different situations in which it evolves. The variation of the resistances is directly related to the fluctuations of the temperature of the machine; whereas the variations of the inductances are related to the phenomenon of magnetic saturation. This type of disturbance is called structured uncertainty.
\n
From above, let us express the electrical parametric variations of the machine, such as:
where the exact part of the plant is represented by the functions (f, g, h), while (∆f, ∆g) represent the uncertain part of the system [19].
\n
A robust control of the uncertainty is not guaranteed by the linear control law. Thus, one should design a robust law based on the Lyapunov theory to achieve an input–output stability and robustness against uncertainty [19].
\n
\n
\n
\n
\n
3. Case study: robust control of a standalone WECS-based PMSG
\n
\n
3.1 System modeling
\n
The schema of the real studied system is presented in Figure 1(a). However, for simplification purposes, and due to the power electronics and local grid dynamics being much faster than other system dynamics, it will not be considered and the simplified system is presented in Figure 1(b) [14].
\n
Figure 1.
Schema of the studied WECS-based PMSG: (a) real system; (b) simplified system.
\n
From Figure 1(b), the control goal is to change the chopper equivalent resistance RL (load) at the generator terminals in order to adjust the generator speed to its optimum value, and then the maximum power capture will be achieved.
\n
The global system model can be expressed part per part in the following equations:
where v(t) is the wind speed (average and turbulent components); \n\n\n\nΓ\nt\n\n\nΓ\ng\n\n\n\n are respectively the turbine and generator torques; \n\n\nP\nt\n\n\n is the mechanical power; \n\n\n\nω\nr\n\n\nω\nh\n\n\n\n are turbine and generator speeds respectively; \n\nρ\n\n is the air density; \n\nR\n\n is the swept surface radius; \n\n\nC\nΓ\n\n\nλ\n\n\n is the torque coefficient; \n\n\n\nq\n0\n\n\nq\n1\n\n\nq\n2\n\n\n\n are given in the appendix; \n\n\nC\nP\n\n\n is the power coefficient; \n\nλ\n\n is the tip speed ratio (TSR); \n\nη\n\n is the efficiency; \n\ni\n\n is the gearbox ration; id, iq, Ld, Lq are respectively the d/q axis currents and inductances; Rs is the stator resistance; p is the pair poles; RL and LL are respectively the resistance and inductance of the equivalent load.
\n
From Eq. (1) to Eq. (3), choosing radius \n\nx\n=\n\n\n\nx\n1\n\n\nx\n2\n\n\nx\n3\n\n\nT\n\n=\n\n\n\ni\nd\n\n\ni\nq\n\n\nω\nh\n\n\nT\n\n\n as state vector, \n\n\nu\n=\n\n\nu\n1\n\n\nu\n2\n\n\n=\n\n\nR\nL\n\nv\n\n\n as control signal and \n\ny\n=\n\nω\nh\n\n\n as a desired output, the nonlinear state space model of the system can be defined as follows:
where \n\n\nd\n1\n\n=\n\n\nηρπ\n\nR\n3\n\n\n\n2\ni\n\n\n\nq\n0\n\n,\n\nd\n2\n\n=\n\n\nηρπ\n\nR\n4\n\n\n\n2\n\ni\n2\n\n\n\n\nq\n1\n\n,\n\nd\n3\n\n=\n\n\nηρπ\n\nR\n5\n\n\n\n2\n\ni\n3\n\n\n\n\nq\n2\n\n.\n\n\n
\n
\n
\n
3.2 Lyapunov linearization method
\n
In this subsection, we will apply the Lyapunov Linearization (first method) to the studied system (Eq. (4)) in order to deal with the system’s small-signal stability under wind speed variation.
\n
Suppose that \n\n\n\nx\n¯\n\n\nu\n¯\n\n\n\n is an equilibrium point and input [20].
\n
Using Taylor’s series expansion of the function f we have:
The linearized version around an equilibrium point characterized by the quintuple \n\n\n\nx\n¯\n\n\nu\n¯\n\n\n=\n\n\n\n\ni\n¯\n\nsd\n\n\n\ni\n¯\n\nsq\n\n\n\nω\n¯\n\nh\n\n\n\nR\n¯\n\nL\n\n\nv\n¯\n\n\n\n\n can be written as follows:
In this section, the small-signal stability of the linearized system will be checked regarding wind speed variation; therefore, we will have a point of view about the impact of the wind speed variation on the system stability. However, in open loop, without control, the system is excited by a wide range of wind speed variation starting from the cut-in to cut-out wind speed. The eigenvalues of the matrix A (Jacobian) are calculated and presented in Table 1.
\n
\n
\n
\n
\n
\n
\n
\n
\n\n
\n
\n\n\n\nv\n¯\n\n\n (m/s)
\n
4
\n
5
\n
6
\n
7
\n
10
\n
12
\n
\n\n\n
\n
\nλ\n1,2\n
\n
−8.56±15i
\n
−7.09±18i
\n
−6.29±20i
\n
−5.74±23i
\n
−5.07±32i
\n
−4.95±37i
\n
\n
\n
\nλ\n3\n
\n
−279
\n
−342
\n
−406
\n
−470
\n
−666
\n
−798
\n
\n\n
Table 1.
Linearized system eigenvalues under wind speed variation.
\n
\nFigure 2 shows clearly that for all values of wind speed, all the eigenvalues still have negative real parts and take places in the left-half of the complex plane, which means the system is almost stable under small perturbation. However, with wind speed increase, the complex-conjugated eigenvalues start immigrating almost close to the imaginary axis and then exhibit bad damping characteristics (Figure 3). Hence, damping should be improved in closed loop-based linear controller.
\n
Figure 2.
Eigenvalues (poles) immigrating under wind speed variation.
\n
Figure 3.
System characteristics regarding damping/overshoot for two wind speed cases (4 m/s left, 12 m/s write).
\n
\n
\n
\n
3.3 System nonlinear feedback linearization
\n
If we assume the wind speed dynamics to be very slow compared to the other system dynamics, the nonlinear system of Eq. (4) can be reformulated as follows:
where \n\n\nd\n1\n\n=\n\n\nηρ\nπ\n\nR\n3\n\n\n\n2\ni\n\n\n\nq\n0\n\n,\n\nd\n2\n\n=\n\n\nηρ\nπ\n\nR\n4\n\n\n\n2\n\ni\n2\n\n\n\n\nq\n1\n\n,\n\nd\n3\n\n=\n\n\nηρ\nπ\n\nR\n5\n\n\n\n2\n\ni\n3\n\n\n\n\nq\n2\n\n.\n\n\n
\n
The system of Eq. (10) has smooth nonlinearities; therefore, the Feedback Linearization Technique can be applied to control the system.
\n
From Eq. (10), taking derivatives of output y with respect to time up to r times will give:
\n\n\n\nL\nf\nr\n\nh\n\nx\n\n\n is the Lie derivative of h(x) along the direction of the vector field f(x) up to r times, \n\n\nL\ng\n\n\nL\nf\n\nr\n−\n1\n\n\nh\n\nx\n\n\nis the Lie derivative of h(x) along the direction of the vector field g(x).\n
\n
\n\nIf we have\n\n\n\n\n\nα\n\nx\n\n=\n\nL\nf\nr\n\nh\n\nx\n\n\n\n\n\nβ\n\nx\n\n=\n\nL\ng\n\n\nL\nf\n\nr\n−\n1\n\n\nh\n\nx\n\n\n\n\n\n\nE12
The relative degree of Eq. (20) is r = 2, it is a linear input–output double-integrator, using linear methods to guarantee the system control (tracking problem).
\n
Note that, the field vectors \n\nα\n\nx\n\n\n and \n\nβ\n\nx\n\n\n should be completely known to apply the feedback linearization technique [21].
\n
The computation of the field vectors \n\nα\n\nx\n\n\n and \n\nβ\n\nx\n\n\n gives:
To harvest the maximum wind power, the generator should be running at optimal speed for each wind speed, thus the generator speed reference can be expressed as follows:
The polynomial \n\n\ns\n2\n\n+\n\nk\n1\n\ns\n+\n\nk\n2\n\n\n would have all its roots in the left-half of the complex plane if we choose an appropriate gain matrix \n\nk\n=\n\n\n\n\n\n\nk\n2\n\n\n\n\nk\n1\n\n\n\n\n\nT\n\n\n. This means that the tracking error asymptotically converges to zero (\n\n\ne\n¨\n\n\nt\n\n+\n\nk\n1\n\n\ne\ṅ\n\n\nt\n\n+\n\nk\n2\n\ne\n\nt\n\n=\n0\n\n). Thus, the system poles are placed following the specifications concerning the overshoots and the settling times.
\n
\n
\n
3.4 Robust control law design
\n
As we mentioned previously, AC machines are subject to a large model uncertainty due to parameter variations, noises, measurement errors etc. In this chapter, we will take into account just electrical and mechanical parametric uncertainties. In the studied case, it is clear that a successful control strategy of the WECS-based PMSG hinges on the good computing of control u, which is strongly dependent on the machine parameters (Eq. (20)). Therefore, we propose a novel robust control law to handle the uncertainty issue and offer an accurate description of the system model [19].
\n
From Section 2.2.1, Eq. (10) can be rewritten as follows:
\n\n\nΔ\nυ\n\n is the effect of uncertainty, it is an unknown term, which makes the linear feedback control law of Eq. (15) incapable of providing a robust tracking performance of the system. Thus, the following robust control law is proposed to handle this issue.
\n
From Eq. (22), we rewrite the error dynamics as follows:
\nEq. (30) is always negative for any value of \n\n\nξ\nT\n\nPB\n\n provided \n\nF\n>\n\n\nΔ\nυ\n\n\n\n. The value of the gain F is chosen accordingly by trial and error.
Based on the control scheme shown in Figure 4, we have simulated within Matlab/Simulink® the studied system shown in Figure 1. The system data are given in the appendix. Through simulation, we have considered that all system variable states (x\n1,\n\nx\n2,\n\nx\n3) are available for feedback. The simulation aims to check two control performances, a wind maximum power tracking performance under a realistic wind speed, and robustness performance against both rapid wind speed variation (sharp) and parametric uncertainty of the generator inertia.
\n
Figure 4.
Robust control simulation scheme.
\n
\n
4.1 Tracking performance check
\n
For tracking performance under wind speed fluctuations (Figure 5(a)–(d)), the power coefficient Cp\n holds easily its maximum value (Cpmax\n) and the same for tip speed ratio, TSR (\n\n\nλ\n∗\n\n\n). Consequently, the PMSG runs at optimal speeds for each wind speed value (see Figure 5(d)) and the maximum power extraction is indeed guaranteed (Figure 6(b)).
\n
Figure 5.
Check of tracking performance under a realistic wind speed. (a) Wind speed; (b) TSR; (c) power coefficient; (d) generator speed.
\n
Figure 6.
(a) Control signal; (b) turbine power; (c) optimal points neighborhood; (d) electromagnetic torque versus TSR.
\n
However, from Figure 6(a), it should be mentioned that the control signal, which represents the equivalent chopper resistance (R\nL), has the chattering phenomenon due to discontinuous control effect (see Eq. (33)). From Figure 6(c) and (d), all system operating points are in the neighborhood of the optimal operating points.
\n
Then, the next simulation is to check the performance of the proposed controller facing critical wind speed conditions. Hence, we have subjected the system to a sharp rise and drop variation of the wind speed (Figure 7(a)). The simulation results show that even under abrupt changes of the wind speed, the system kept its stability and continued working after some short transitory disturbances and small static errors, which can be observed through Figure 7(a)-(c) and Figure 8(a)-(c).
(a) Power coefficient; (b) tip speed ratio; (c) generator speed.
\n
\n
\n
4.2 Parametric uncertainty robustness check
\n
Following Eq. (14) and Eq. (16), it is obvious that the control signal is calculated based on field vectors \n\nα\n\nx\n\n\n and \n\nβ\n\nx\n\n\n whose values are strongly dependent on the system parameters, especially the high speed shaft inertia J\nh. Thus, in order to check the proposed controller robustness against this parametric uncertainty, we have simulated the system with sharp variation of high speed shaft inertia as shown in Figure 9(a). From the obtained simulation results (Figures 10 and 11), except small static errors and very small disturbances, this parametric uncertainty would not have any notable effect on the stability of the control scheme. However, the field vectors \n\nα\n\nx\n\n\n and \n\nβ\n\nx\n\n\n dynamics, the control signal and the generator speed can be shown in and Figure 12.
\n
Figure 9.
(a) High speed shaft inertia; (b) average wind speed.
\n
Figure 10.
Power coefficient Cp.
\n
Figure 11.
Tip speed ratio.
\n
Figure 12.
(a) Control signal; (b) generator speed; (c) α(x); (d) β(x).
\n
\n
\n
\n
5. Conclusion
\n
In this chapter, we have discussed the robust control technique based on Lyapunov theory to ensure tracking performance and robustness of a nonlinear system. Mainly, the chapter presents this control strategy based on a case study of a standalone nonlinear WECS-based PMSG. In fact, we focused on tracking performance to ensure maximum wind power extraction and robustness performance against parametric uncertainty. Whereas, the control strategy uses the state feedback linearization technique associated with a control law derived from the Lyapunov theory. The obtained results through simulation have proved the efficiency of the proposed control technique.
\n',keywords:"WECS, PMSG, eigenvalues, nonlinear feedback control, Lyapunov theory, robust control",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70703.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70703.xml",downloadPdfUrl:"/chapter/pdf-download/70703",previewPdfUrl:"/chapter/pdf-preview/70703",totalDownloads:530,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:34,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"January 28th 2019",dateReviewed:"December 3rd 2019",datePrePublished:null,datePublished:"April 15th 2020",dateFinished:"January 2nd 2020",readingETA:"0",abstract:"This chapter presents a case study of robust nonlinear control strategy using nonlinear feedback control technique based on Lyapunov theory and associated with robust control laws. The proposed approach aims to enhance robustness of the wind turbine control scheme. In fact, we selected as a case study, the most used electrical generator in small-scale wind applications, the Permanent Magnet Synchronous Generator (PMSM). Indeed, the control strategy presented in this chapter allows an efficient operation of the wind turbine in the standalone operating mode, offers a nonlinear handling of the WECS(s) and guarantees maximum wind power harvesting and robustness against critical working conditions. Talking about stability, in several wind generator control schemes; a such classical PI controllers-based scheme can easily be disturbed by any uncertainty of the system parameters, thus, in this chapter, we focused on how to overcome this issue by proposing a robust control strategy based on nonlinear controller derived from the Lyapunov Theory. The chapter presents numerical simulations within Matlab/SIMULINK environment. These results proved the effectiveness and the benefits of the proposed approach.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70703",risUrl:"/chapter/ris/70703",book:{id:"8890",slug:"design-optimization-of-wind-energy-conversion-systems-with-applications"},signatures:"Ridha Cheikh and Hocine Belmili",authors:[{id:"249883",title:"Dr.",name:"Hocine",middleName:null,surname:"Belmili",fullName:"Hocine Belmili",slug:"hocine-belmili",email:"belmilih@yahoo.fr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"260098",title:"Ph.D.",name:"Ridha",middleName:null,surname:"Cheikh",fullName:"Ridha Cheikh",slug:"ridha-cheikh",email:"cheikh_red@yahoo.fr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Lyapunov theory and robust control association",level:"1"},{id:"sec_2_2",title:"2.1 Lyapunov theory fundamentals",level:"2"},{id:"sec_2_3",title:"2.1.1 Lyapunov’s direct method concept",level:"3"},{id:"sec_3_3",title:"2.1.2 Stability of a linear system",level:"3"},{id:"sec_5_2",title:"2.2 Modeling of parametric uncertainty for AC machines",level:"2"},{id:"sec_5_3",title:"2.2.1 Resistance variation",level:"3"},{id:"sec_6_3",title:"2.2.2 Inductance variation",level:"3"},{id:"sec_7_3",title:"2.2.3 Skin effect",level:"3"},{id:"sec_8_3",title:"2.2.4 Global uncertainty model",level:"3"},{id:"sec_11",title:"3. Case study: robust control of a standalone WECS-based PMSG",level:"1"},{id:"sec_11_2",title:"3.1 System modeling",level:"2"},{id:"sec_12_2",title:"3.2 Lyapunov linearization method",level:"2"},{id:"sec_12_3",title:"Table 1.",level:"3"},{id:"sec_14_2",title:"3.3 System nonlinear feedback linearization",level:"2"},{id:"sec_15_2",title:"3.4 Robust control law design",level:"2"},{id:"sec_17",title:"4. Simulation results and discussion",level:"1"},{id:"sec_17_2",title:"4.1 Tracking performance check",level:"2"},{id:"sec_18_2",title:"4.2 Parametric uncertainty robustness check",level:"2"},{id:"sec_20",title:"5. Conclusion",level:"1"},{id:"sec_22",title:"",level:"1"}],chapterReferences:[{id:"B1",body:'\n\nAvailable from: https://unfccc.int/resource/bigpicture/#content-the-paris-agreement\n\n'},{id:"B2",body:'\nGlobal Wind Energy Council (GWEC). Global wind statistics. Report 2018. 2018. Available at: www.gwec.net [Accessed: April 2019]\n'},{id:"B3",body:'\nFlynn D et al. Advances in Energy Systems, Technical Impacts of High Penetration Levels of Wind Power on Power System Stability: The Large-scale Renewable Energy Integration Challenge. 1st ed. John Wiley & Sons Ltd; 2019. DOI: 10.1002/9781119508311.ch3\n'},{id:"B4",body:'\nWind Europe. 2019. Available at: https://windeurope.org/about-wind/daily-wind/\n\n'},{id:"B5",body:'\nGeng H et al. LVRT capability of DFIG-based WECS under asymmetrical grid fault condition. IEEE Transactions on Industrial Electronics. 2013;60(6):2495-2409\n'},{id:"B6",body:'\nShuai Xiao, Hong lin Zhou. An LVRT control strategy based on flux linkage tracking for DFIG-based WECS. IEEE Transactions on Industrial Electronics. 2013;60(7):2820-2832\n'},{id:"B7",body:'\nGupta A, Shandilya A. Challenges of integration of wind power on power system grid: A review. International Journal of Emerging Technology and Advanced Engineering. 2014;4(4):880-884\n'},{id:"B8",body:'\nPoitier F. Study and control of asynchronous generator for the use of wind energy-stand-alone induction machine-grid-connected double fed induction machine [PhD thesis]. Polytechnic School of the University of Nantes; 2003\n'},{id:"B9",body:'\nEl Aimani S. Modeling of different wind turbine technologies integrated into a medium voltage network [PhD thesis]. École Centrale of Lille; 2004\n'},{id:"B10",body:'\nAbad G et al. Doubly Fed Induction Machine Modeling and Control for Wind Energy Generation. 1st ed. IEEE-John Wiley & Sons, Inc.; 2011\n'},{id:"B11",body:'\nPena R et al. Doubly fed induction generator using back-to-back PWM converters and its application to variable-speed wind-energy generation. IEE Proceedings—Electric Power Applications. 1996;143(3):231-241\n'},{id:"B12",body:'\nCheikh R et al. Robust nonlinear control via feedback linearization and Lyapunov theory for permanent magnet synchronous generator-based wind energy conversion system. Frontier in Energy. 2018;12(46):1-12\n'},{id:"B13",body:'\nDawson DM et al. Nonlinear Control of Electric Machinery. 1st ed. UK: Taylor & Francis Group; 1998. DOI: 10.1201/9780203745632\n'},{id:"B14",body:'\nMunteanu I et al. Optimal Control of Wind Energy Systems: Toward a Global Approach. UK: Springer-Verlag London Limited; 2008\n'},{id:"B15",body:'\nSlotine JJE, Li W. Applied Nonlinear Control. New Jersey: Prentice-Hall, Inc.; 1991\n'},{id:"B16",body:'\nMurray RM, Li Z, Sastry SS. A Mathematical Introduction to Robotic Manipulation. CRC Press; 1993\n'},{id:"B17",body:'\nAbdelmalek G. Commande Robuste d’un Dispositif FACTS par les Méthodes Métaheuristiques pour la Stabilité de Tension d’un Réseau Electrique [thesis]. Department of Electrical Engineering, Biskra University University; 2019\n'},{id:"B18",body:'\nPenman J, Sedding HG, Lloyf BA, Fink WT. Detection and location of interturns short circuits in the stator windings of operating motors. IEEE Transactions on Energy Conversion. 1994;9(4)\n'},{id:"B19",body:'\nRidha C et al. Robust control based on the Lyapunov theory of a grid-connected doubly fed induction. Frontiers in Energy. 2013;7(2):191-196. DOI: 10.1007/s11708-013-0245-y\n'},{id:"B20",body:'\nTailor MR, Bhathawala PH. Linearization of nonlinear differential equation by Taylor’s series expansion and use of Jacobian linearization process. International Journal of Theoretical and Applied Science. 2011;4(1):36-38\n'},{id:"B21",body:'\nIsidori A. Nonlinear Control Systems. 3rd ed. Berlin: Springer-Verlag; 1995\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ridha Cheikh",address:"cheikh_red@yahoo.fr",affiliation:'
Unité de Développement des Equipements Solaires, UDES, Centre de Développement des Energies Renouvelables, CDER, Tipaza, Algeria
Unité de Développement des Equipements Solaires, UDES, Centre de Développement des Energies Renouvelables, CDER, Tipaza, Algeria
'}],corrections:null},book:{id:"8890",type:"book",title:"Design Optimization of Wind Energy Conversion Systems with Applications",subtitle:null,fullTitle:"Design Optimization of Wind Energy Conversion Systems with Applications",slug:"design-optimization-of-wind-energy-conversion-systems-with-applications",publishedDate:"April 15th 2020",bookSignature:"Karam Y. Maalawi",coverURL:"https://cdn.intechopen.com/books/images_new/8890.jpg",licenceType:"CC BY-NC 4.0",editedByType:"Edited by",isbn:"978-1-78984-408-5",printIsbn:"978-1-78984-407-8",pdfIsbn:"978-1-83880-329-2",reviewType:"peer-reviewed",numberOfWosCitations:0,isAvailableForWebshopOrdering:!0,editors:[{id:"18593",title:"Prof.",name:"Karam",middleName:"Youssef",surname:"Maalawi",slug:"karam-maalawi",fullName:"Karam Maalawi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"764"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"70089",type:"chapter",title:"Optimal Energy Production Planning in Power Systems with Wind Energy Sources",slug:"optimal-energy-production-planning-in-power-systems-with-wind-energy-sources",totalDownloads:720,totalCrossrefCites:0,signatures:"Cristian-Dragos Dumitru and Adrian Gligor",reviewType:"peer-reviewed",authors:[{id:"296022",title:"Dr.Ing.",name:"Dumitru",middleName:null,surname:"Cristian-Dragos",fullName:"Dumitru Cristian-Dragos",slug:"dumitru-cristian-dragos"},{id:"296024",title:"Dr.",name:"Gligor",middleName:null,surname:"Adrian",fullName:"Gligor Adrian",slug:"gligor-adrian"}]},{id:"70217",type:"chapter",title:"A Research Framework for the Multidisciplinary Design and Optimization of Wind Turbines",slug:"a-research-framework-for-the-multidisciplinary-design-and-optimization-of-wind-turbines",totalDownloads:658,totalCrossrefCites:0,signatures:"Luca Sartori, Stefano Cacciola, Alessandro Croce and Carlo Emanuele Dionigi Riboldi",reviewType:"peer-reviewed",authors:[{id:"295242",title:"Prof.",name:"Carlo Emanuele Dionigi",middleName:null,surname:"Riboldi",fullName:"Carlo Emanuele Dionigi Riboldi",slug:"carlo-emanuele-dionigi-riboldi"},{id:"297534",title:"Prof.",name:"Alessandro",middleName:null,surname:"Croce",fullName:"Alessandro Croce",slug:"alessandro-croce"},{id:"297535",title:"Prof.",name:"Stefano",middleName:null,surname:"Cacciola",fullName:"Stefano Cacciola",slug:"stefano-cacciola"},{id:"297536",title:"Dr.",name:"Luca",middleName:null,surname:"Sartori",fullName:"Luca Sartori",slug:"luca-sartori"}]},{id:"69674",type:"chapter",title:"Wind Turbine Airfoil Boundary Layer Optimization Using Genetic Algorithm with 3D Rotational Augmentation",slug:"wind-turbine-airfoil-boundary-layer-optimization-using-genetic-algorithm-with-3d-rotational-augmenta",totalDownloads:538,totalCrossrefCites:1,signatures:"Youjin Kim, Galih Bangga and Antonio Delgado",reviewType:"peer-reviewed",authors:[{id:"208318",title:"M.Sc.",name:"Youjin",middleName:null,surname:"Kim",fullName:"Youjin Kim",slug:"youjin-kim"},{id:"208321",title:"Prof.",name:"Antonio",middleName:null,surname:"Delgado",fullName:"Antonio Delgado",slug:"antonio-delgado"},{id:"312157",title:"Dr.",name:"Galih",middleName:null,surname:"Bangga",fullName:"Galih Bangga",slug:"galih-bangga"}]},{id:"71507",type:"chapter",title:"Structural Optimization of Wind Turbine Blades for Improved Dynamic Performance",slug:"structural-optimization-of-wind-turbine-blades-for-improved-dynamic-performance",totalDownloads:839,totalCrossrefCites:0,signatures:"Gerges Edwar Mehanny Beshay and Karam Yousef Maalawi",reviewType:"peer-reviewed",authors:[{id:"150041",title:"Prof.",name:"Karam",middleName:"Youssef",surname:"Maalawi",fullName:"Karam Maalawi",slug:"karam-maalawi"},{id:"282747",title:"Dr.",name:"Gerges",middleName:"Edwar",surname:"Beshay",fullName:"Gerges Beshay",slug:"gerges-beshay"}]},{id:"69636",type:"chapter",title:"Aerodynamic, Structural and Aeroelastic Design of Wind Turbine Blades",slug:"aerodynamic-structural-and-aeroelastic-design-of-wind-turbine-blades",totalDownloads:830,totalCrossrefCites:0,signatures:"Mohamed Abdou Mahran Kasem",reviewType:"peer-reviewed",authors:[{id:"283541",title:"Dr.",name:"Mohamed",middleName:null,surname:"Kasem",fullName:"Mohamed Kasem",slug:"mohamed-kasem"}]},{id:"70832",type:"chapter",title:"Synthesis and Optimization of Wind Energy Conversion Devices",slug:"synthesis-and-optimization-of-wind-energy-conversion-devices",totalDownloads:570,totalCrossrefCites:1,signatures:"Janis Viba, Vitaly Beresnevich and Martins Irbe",reviewType:"peer-reviewed",authors:[{id:"64918",title:"Prof.",name:"Janis",middleName:null,surname:"Viba",fullName:"Janis Viba",slug:"janis-viba"},{id:"295276",title:"Prof.",name:"Vitaly",middleName:null,surname:"Beresnevich",fullName:"Vitaly Beresnevich",slug:"vitaly-beresnevich"},{id:"295282",title:"MSc.",name:"Martins",middleName:null,surname:"Irbe",fullName:"Martins Irbe",slug:"martins-irbe"}]},{id:"70259",type:"chapter",title:"Optimal Design and Operational Monitoring of Wind Turbine Blades",slug:"optimal-design-and-operational-monitoring-of-wind-turbine-blades",totalDownloads:575,totalCrossrefCites:0,signatures:"Francis Xavier Ochieng, Craig Matthew Hancock, Gethin Wyn Roberts and Julien Le Kernec",reviewType:"peer-reviewed",authors:[{id:"297395",title:"Dr.",name:"Francis Xavier",middleName:null,surname:"Ochieng",fullName:"Francis Xavier Ochieng",slug:"francis-xavier-ochieng"},{id:"313384",title:"Dr.",name:"Craig Matthew",middleName:null,surname:"Hancock",fullName:"Craig Matthew Hancock",slug:"craig-matthew-hancock"},{id:"313385",title:"Dr.",name:"Gethin Wyn",middleName:null,surname:"Roberts",fullName:"Gethin Wyn Roberts",slug:"gethin-wyn-roberts"},{id:"313386",title:"Dr.",name:"Julien",middleName:null,surname:"Le Kernec",fullName:"Julien Le Kernec",slug:"julien-le-kernec"}]},{id:"70100",type:"chapter",title:"The Use of Electrical Measurements of Wind Turbine Generators for Drive Train Condition Monitoring",slug:"the-use-of-electrical-measurements-of-wind-turbine-generators-for-drive-train-condition-monitoring",totalDownloads:480,totalCrossrefCites:1,signatures:"Estefania Artigao, Andrés Honrubia-Escribano, Sergio Martín-Martínez and Emilio Gómez-Lázaro",reviewType:"peer-reviewed",authors:[{id:"153168",title:"Prof.",name:"Emilio",middleName:null,surname:"Gomez-Lazaro",fullName:"Emilio Gomez-Lazaro",slug:"emilio-gomez-lazaro"},{id:"154137",title:"Mr.",name:"Sergio",middleName:null,surname:"Martín Martínez",fullName:"Sergio Martín Martínez",slug:"sergio-martin-martinez"},{id:"224120",title:"Dr.",name:"Andrés",middleName:null,surname:"Honrubia-Escribano",fullName:"Andrés Honrubia-Escribano",slug:"andres-honrubia-escribano"},{id:"295497",title:"Dr.",name:"Estefania",middleName:null,surname:"Artigao",fullName:"Estefania Artigao",slug:"estefania-artigao"}]},{id:"70272",type:"chapter",title:"Reliability Assessment of Wind Turbines",slug:"reliability-assessment-of-wind-turbines",totalDownloads:551,totalCrossrefCites:0,signatures:"Mai F.M. Ayoub",reviewType:"peer-reviewed",authors:[{id:"281617",title:"Ph.D. Student",name:"Mai",middleName:null,surname:"Ayoub",fullName:"Mai Ayoub",slug:"mai-ayoub"}]},{id:"68984",type:"chapter",title:"Wind Energy Conversion System Modeling toward Different Approaches",slug:"wind-energy-conversion-system-modeling-toward-different-approaches",totalDownloads:617,totalCrossrefCites:1,signatures:"Ali El Yaakoubi, Lahcen Amhaimar and Adel Asselman",reviewType:"peer-reviewed",authors:[{id:"306573",title:"Ph.D.",name:"Ali",middleName:null,surname:"El Yaakoubi",fullName:"Ali El Yaakoubi",slug:"ali-el-yaakoubi"},{id:"308628",title:"Dr.",name:"Lahcen",middleName:null,surname:"Amhaimar",fullName:"Lahcen Amhaimar",slug:"lahcen-amhaimar"},{id:"308630",title:"Prof.",name:"Adel",middleName:null,surname:"Asselman",fullName:"Adel Asselman",slug:"adel-asselman"}]},{id:"70703",type:"chapter",title:"Robust Nonlinear Control Strategy for Small Wind Turbines: A Case Study",slug:"robust-nonlinear-control-strategy-for-small-wind-turbines-a-case-study",totalDownloads:530,totalCrossrefCites:0,signatures:"Ridha Cheikh and Hocine Belmili",reviewType:"peer-reviewed",authors:[{id:"249883",title:"Dr.",name:"Hocine",middleName:null,surname:"Belmili",fullName:"Hocine Belmili",slug:"hocine-belmili"},{id:"260098",title:"Ph.D.",name:"Ridha",middleName:null,surname:"Cheikh",fullName:"Ridha Cheikh",slug:"ridha-cheikh"}]}]},relatedBooks:[{type:"book",id:"7277",title:"Optimum Composite Structures",subtitle:null,isOpenForSubmission:!1,hash:"d25c7d0dfa4679385ef2dbc2c0adefa1",slug:"optimum-composite-structures",bookSignature:"Karam Y. Maalawi",coverURL:"https://cdn.intechopen.com/books/images_new/7277.jpg",editedByType:"Edited by",editors:[{id:"18593",title:"Prof.",name:"Karam",surname:"Maalawi",slug:"karam-maalawi",fullName:"Karam Maalawi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"63652",title:"Introductory Chapter: An Introduction to the Optimization of Composite Structures",slug:"introductory-chapter-an-introduction-to-the-optimization-of-composite-structures",signatures:"Karam Maalawi",authors:[{id:"18593",title:"Prof.",name:"Karam",middleName:"Youssef",surname:"Maalawi",fullName:"Karam Maalawi",slug:"karam-maalawi"}]},{id:"62131",title:"Mathematical Modeling and Numerical Optimization of Composite Structures",slug:"mathematical-modeling-and-numerical-optimization-of-composite-structures",signatures:"Sergey Golushko",authors:[null]},{id:"61089",title:"Optimization of Lay-Up Stacking for a Loaded-Carrying Slender Composite Beam",slug:"optimization-of-lay-up-stacking-for-a-loaded-carrying-slender-composite-beam",signatures:"Sergey Shevtsov, Igor Zhilyaev, Natalia Snezhina and WU Jiing-Kae",authors:[null]},{id:"62484",title:"Design Optimization and Higher Order FEA of Hat-Stiffened Aerospace Composite Structures",slug:"design-optimization-and-higher-order-fea-of-hat-stiffened-aerospace-composite-structures",signatures:"Bo Cheng Jin",authors:[{id:"226009",title:"Dr.",name:"Bo",middleName:null,surname:"Jin",fullName:"Bo Jin",slug:"bo-jin"}]},{id:"62669",title:"The Guidelines of Material Design and Process Control on Hybrid Fiber Metal Laminate for Aircraft Structures",slug:"the-guidelines-of-material-design-and-process-control-on-hybrid-fiber-metal-laminate-for-aircraft-st",signatures:"Sang Yoon Park and Won Jong Choi",authors:[null]},{id:"62942",title:"Fiber-Metal Laminate Panels Reinforced with Metal Pins",slug:"fiber-metal-laminate-panels-reinforced-with-metal-pins",signatures:"Ruham Pablo Reis, Iaroslav Skhabovskyi, Alberto Lima Santos,\nLeonardo Sanches, Edson Cocchieri Botelho and Américo Scotti",authors:[null]},{id:"62257",title:"Design Optimization of Reinforced Ordinary and High-Strength Concrete Beams with Eurocode2 (EC-2)",slug:"design-optimization-of-reinforced-ordinary-and-high-strength-concrete-beams-with-eurocode2-ec-2-",signatures:"Fedghouche Ferhat",authors:[null]},{id:"62768",title:"Improved Dielectric Properties of Epoxy Nano Composites",slug:"improved-dielectric-properties-of-epoxy-nano-composites",signatures:"Rashmi Aradhya and Nijagal M. Renukappa",authors:[{id:"227309",title:"Dr.",name:"Rashmi",middleName:null,surname:"Aradhya",fullName:"Rashmi Aradhya",slug:"rashmi-aradhya"},{id:"227469",title:"Dr.",name:"Nijagal M.",middleName:null,surname:"Renukappa",fullName:"Nijagal M. Renukappa",slug:"nijagal-m.-renukappa"}]},{id:"64535",title:"Optimization of Functionally Graded Material Structures: Some Case Studies",slug:"optimization-of-functionally-graded-material-structures-some-case-studies",signatures:"Karam Maalawi",authors:[{id:"18593",title:"Prof.",name:"Karam",middleName:"Youssef",surname:"Maalawi",fullName:"Karam Maalawi",slug:"karam-maalawi"}]}]}],publishedBooks:[{type:"book",id:"5361",title:"Energy Efficient Buildings",subtitle:null,isOpenForSubmission:!1,hash:"b479633e09d7149b2fb8014839035f5a",slug:"energy-efficient-buildings",bookSignature:"Eng Hwa Yap",coverURL:"https://cdn.intechopen.com/books/images_new/5361.jpg",editedByType:"Edited by",editors:[{id:"185577",title:"Associate Prof.",name:"Eng Hwa",surname:"Yap",slug:"eng-hwa-yap",fullName:"Eng Hwa Yap"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8890",title:"Design Optimization of Wind Energy Conversion Systems with Applications",subtitle:null,isOpenForSubmission:!1,hash:"a2ce9419202c074e3aee8dff0d87326c",slug:"design-optimization-of-wind-energy-conversion-systems-with-applications",bookSignature:"Karam Y. Maalawi",coverURL:"https://cdn.intechopen.com/books/images_new/8890.jpg",editedByType:"Edited by",editors:[{id:"18593",title:"Prof.",name:"Karam",surname:"Maalawi",slug:"karam-maalawi",fullName:"Karam Maalawi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7707",title:"A Guide to Small-Scale Energy Harvesting Techniques",subtitle:null,isOpenForSubmission:!1,hash:"47d7741e30a569a74a8aa981a7b7a902",slug:"a-guide-to-small-scale-energy-harvesting-techniques",bookSignature:"Reccab Manyala",coverURL:"https://cdn.intechopen.com/books/images_new/7707.jpg",editedByType:"Edited by",editors:[{id:"12002",title:"Associate Prof.",name:"Reccab",surname:"Manyala",slug:"reccab-manyala",fullName:"Reccab Manyala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8124",title:"Advances in Modelling and Control of Wind and Hydrogenerators",subtitle:null,isOpenForSubmission:!1,hash:"8cf2591492537f75db940baa712582e5",slug:"advances-in-modelling-and-control-of-wind-and-hydrogenerators",bookSignature:"Amir Ebrahimi",coverURL:"https://cdn.intechopen.com/books/images_new/8124.jpg",editedByType:"Edited by",editors:[{id:"256252",title:"Dr.",name:"Amir",surname:"Ebrahimi",slug:"amir-ebrahimi",fullName:"Amir Ebrahimi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8572",title:"Thermodynamics and Energy Engineering",subtitle:null,isOpenForSubmission:!1,hash:"e2e9e95bd0be692c5364418f341102b6",slug:"thermodynamics-and-energy-engineering",bookSignature:"Petrică Vizureanu",coverURL:"https://cdn.intechopen.com/books/images_new/8572.jpg",editedByType:"Edited by",editors:[{id:"12354",title:"Prof.",name:"Petrică",surname:"Vizureanu",slug:"petrica-vizureanu",fullName:"Petrică Vizureanu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"8890",title:"Design Optimization of Wind Energy Conversion Systems with Applications",subtitle:null,isOpenForSubmission:!1,hash:"a2ce9419202c074e3aee8dff0d87326c",slug:"design-optimization-of-wind-energy-conversion-systems-with-applications",bookSignature:"Karam Y. Maalawi",coverURL:"https://cdn.intechopen.com/books/images_new/8890.jpg",editedByType:"Edited by",editors:[{id:"18593",title:"Prof.",name:"Karam",surname:"Maalawi",slug:"karam-maalawi",fullName:"Karam Maalawi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"79235",title:"Mechanistic Role of Reactive Oxygen Species and Its Regulation via the Antioxidant System under Environmental Stress",doi:"10.5772/intechopen.101045",slug:"mechanistic-role-of-reactive-oxygen-species-and-its-regulation-em-via-em-the-antioxidant-system-unde",body:'
1. Introduction
Plants are continually susceptible to environmental changes, prompting them to regulate their metabolism in such a way as to maintain a constant balance between the generation of energy and its consumption. This delicate balance is majorly dependent on a network signaling that mainly coordinates among the key operations in plant life including dark respiration, photorespiration, and photosynthesis, all of these activities are linked by reductants, substrate, energy, and electron transfer [1, 2]. Plant organelle metabolic pathways are sensitive to climate change and metabolic inequities in cells that can cause oxidative stress by boosting the oxidation of cellular components, production as well as accumulation of reactive oxygen species (ROS), impeding metabolic activities, and affecting organelle integrity [3, 4].
Environmental abiotic stresses, such as chilling, salinity, harsh temperature, drought, toxic metals or metalloids, flooding/waterlogging, and ultraviolet (UV) radiation, have become more common as a result of abrupt and extreme climate change [5]. The escalation of various abiotic stresses emerged as a key threat to agricultural crop production. Furthermore, an excess of ROS such as free radical alkoxy radical (RO•); hydroperoxyl radical (HO2•); hydroxyl radical (OH•); superoxide anion (O2•); and nonradical molecules (singlet oxygen, 1O2, and hydrogen peroxide, H2O2) causes plant oxidative stress [6]. The principal sites of cellular ROS formation are mitochondria, chloroplast, apoplast, plasma membranes, and peroxisome [7]. Although as a component of regular cellular metabolism ROS are produced in plants, their overabundance due to several stresses severely destroys essential cellular constituents such as DNA, proteins, carbohydrates, lipids, and so on due to their highly reactive nature [8]. Nonenzymatic, low-molecular substances such as ascorbic acid (AA), reduced glutathione (GSH), carotenoids, tocopherol, proline, phenols, and flavonoids as well as guaiacol peroxidase (GPX), peroxidase (APX), superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST). The pervasiveness of both of the antioxidant machinery’s arms supports the necessity for ROS detoxification for cellular viability [9].
1.1 Types of ROS
ROS are generally a molecular O2 that has been incompletely activated or reduced or the principal product or the O2-containing molecule byproduct that has an elevated reactivity than ambient O2. ROS are produced by the electrons from the O2 molecule or transfer of energy. The most prevalent cellular ROS in plants are OH•, O2•, 1O2, and H2O2. Cells generate both nonradical and free radical ROS. Free radicals include OH•, O2•, ROO•, and RO•, while the nonradicals include 1O2 and H2O2. The other ROS nonradicals found in plants include excited carbonyl (RO*) and hypochlorous acid (HOCl). Furthermore, few acidic molecules such as hypoiodous acid (HOI), hypobromous acid (HOBr), and hypochlorous acid (HOCl) and radical compound (CO3•) are incorporated into ROS. In addition, biological systems may contain alkoxyl radical (LO•), peroxyl radical (LOO•), hydroperoxyl radical (HO2•), peroxynitrite (HNO3), trichloromethyl peroxyl radical (Cl3COO•), and ozone (O3).
1.1.1 Superoxide radical (O2•−)
In the chloroplasts, ROS are constantly produced as a result of partial O2 reduction or energy transfer to O2. During the noncyclic electron transport chain (ETC), O2•− is generated mostly in the thylakoid localized PSI and other cellular compartments. When cytochrome c oxidase reacts with O2, H2O is normally produced. Occasionally, O2 reacts with the various ETC components to produce O2•. It is typically the first ROS to develop. O2•− can potentially undergo a further reaction, resulting in the formation of other ROS [10].
1.1.2 Singlet oxygen (1O2)
It is an unusual ROS that is produced via the chlorophyll reaction (in the antenna system, in the triplet state) rather than electron transport to O2. Heavy metals, salinity, and drought all cause stomatal closure, resulting in lack of intracellular CO2 concentration. Facilitating the production of 1O2 and causing significant damage to both the photosystems (PSI and PSII) put the whole photosynthetic apparatus in danger, causing damage to a wide spectrum of the target. These substances include pigments, proteins, lipids, and nucleic acids and are the primary ROS responsible for light-induced loss of PSII function, resulting in cellular death [11].
1.1.3 Hydrogen peroxide (H2O2)
It is created in plant cells under normal conditions as well as in response to oxidative stresses (drought, cold, UV radiation, bright light, pathogen infection, and wounding). O2•− undergoes both univalent protonation and reduction, and a moderately reactive H2O2 is produced. The ER, mitochondria, ETC in the chloroplast, oxidation of fatty acids, photorespiration, and cell membrane are the key sources of H2O2 generation in plant cells. In plants, H2O2 is useful at low quantities but harmful at greater amounts. It operates as a regulatory signal for critical physiological processes such as senescence, stomatal movement, photosynthesis and photorespiration, growth as well as development at low intracellular concentrations [12].
1.1.4 Hydroxyl radical (OH•)
OH• is the most reactive and destructive ROS. At neutral pH, it is produced via the Fenton reaction between H2O2 and O2•− catalyzed by transition metals such as Fe (Fe2+, Fe3+). H2O2 + O2•− → OH− + O2 + OH•. It is capable of causing harm to several biological components through lipid peroxidation (LPO), protein degradation, and membrane disintegration. Because no enzymatic system exists to scavenge this deadly radical, excessive OH• buildup causes cellular death [13].
1.1.5 Peroxyl radical (ROO•)
The key chain-propagating step in lipid peroxidation and non-lipid systems is the formation of RO2• and RO• radicals that can be generated by the decomposition of protein and lipid peroxides when heated or by the addition of transition metal ions. It is easy to produce peroxyl radicals by combining O2 with carbon-centered radical >C• + O2 > C−OO•. The peroxyl radical plays an important role in the oxidation of lipids, DNA damage, changes in the protein backbone, and the degradation of food.
1.1.6 Alkoxy radical (RO•)
When lipids are oxidatively degraded or peroxidized without the help of enzymes, alkoxyl radicals are generated by the Fenton reaction, by electron reductions, or by combining two peroxyl radicals. Apoptosis and DNA alterations may result from alkyl radical oxidation. DNA damage and apoptosis can be caused by alkoxyl radicals, which are very oxidizing.
2. Sites of ROS production/generation in plant cells
It is proven that ROS can be produced in multiple places in the mitochondria, chloroplasts, plasma membranes, peroxisomes, endoplasmic reticulum, and cell wall both under normal and stressful conditions. ROS are produced primarily by peroxisomes and chloroplasts when light is present, while the mitochondria generate ROS when light is not present.
2.1 Chloroplast
Chlorophyll (chl) and light interact with each other to produce ROS in the chloroplast, which is the most important site where ROS are produced. In this case, ROS are principally generated by triplet chl and electron transport chains (ETC), including PSI and PSII. SOD converts O2•− into H2O2 under PSI in the Mehler reaction [14]. The O2•− and H2O2 generate more highly reactive HO• when combined with metal ions such as Fe2+. Various ecological stressors cause stomatal closure, resulting in a decrease in CO2 levels, thereby causing the generation of chloroplastic ROS [3, 15].
2.2 Mitochondria
Although on a smaller scale, mitochondria are also responsible for damaging ROS production, including H2O2 and O2•−. This is due to the mitochondrial ETC (mt ETC) containing enough energetic electrons to reduce O2 and produce ROS. The two main mt ETC components responsible for the production of ROS are complexes I and III [16]. Additionally, the mitochondrial matrix contains numerous enzymes that produce ROS. Mn-SOD and APX reduce O2 into H2O2 under the influence of oxygen, despite its abundance in the mitochondria. When mitochondria are under abiotic stress, ROS production increases dramatically [17].
2.3 Apoplast
The diffusible region around the plant cell membrane appears to be in charge of converting incoming CO2 into a soluble, diffusible form that can be transported into the cytoplasm to carry out photosynthesis. During the harsh environmental situation, stress signals combined with abscisic acid make the apoplast a significant location for H2O2 production. Several other substances, such as pH-dependent peroxidases (POXs), polyamine oxidases, and cell-wall-linked oxidases, also generate ROS [18].
2.4 Plasma membranes
Plant cells are surrounded by a plasma membrane, which is constantly interacting with changing external conditions, thereby providing essential information for their survival.
During electrons transferring from cytosolic NADPH to O2, either e− dismutates spontaneously to H2O2 or is catalyzed by NADPH oxidase; SOD forms O•2. The importance of NADPH oxidase in plant defense against pathogenic infection and abiotic stress conditions has been well established [19].
2.5 Cell walls
The cell wall-localized lipoxygenase (LOX) creates polyunsaturated fatty acid (PUFA) hydroperoxidation, making it an active generator of ROS such as O2•, OH•, 1O2, and H2O2. Using diamines or polyamines, cell wall-localized diamine oxidases produce ROS in the cell wall. During the pathogenic attack, lignin precursors undergo considerable cross-linking via H2O2-mediated pathways, resulting in the formation of recombinant lignin [20].
2.6 Endoplasmic reticulum (ER)
Cyt P450, which is located in the ER, is used to create O2•−via NADPH-mediated electron transport. RH (an organic substrate) interacts with CytP450, which is formerly reduced by a flavoprotein to form a free-radical intermediate (Cyt P450 R). This intermediate forms an oxygenated complex when it reacts with triplet oxygen (3O2) (Cyt P450-ROO). When the complex decomposes to Cyt P450-Rh, O2• is produced as a byproduct [21].
3. Role of ROS as messengers
ROS have been identified as the second messenger in intracellular signaling cascades that mediate a variety of plant responses, including programmed cell death, stomatal closure, gravitropism, and abiotic and biotic stress-tolerance acquisition. ROS can also affect the activity of numerous signaling components, including protein phosphatases, transcription factors, and protein kinases as well as communicate with other signal molecules and the pathway that administers response downstream of ROS. The balance between oxidant formation and antioxidant removal determines the life span, strength, and size of the ROS signaling pool [19, 20].
4. ROS and oxidative damage to biomolecules
The creation and removal of reactive oxygen species must be appropriately regulated to avoid oxidative stress. When the number of reactive oxygen species exceeds the cell’s defensive systems, the cell is said to be in “oxidative stress.” The balance between ROS formation and scavenging is upset in several stressful circumstances, such as salt, thirst, metal toxicity, intense light, viruses, and so on. High quantities of ROS can harm biomolecules, such as lipids, proteins, and DNA. These processes can alter inherent membrane properties including fluidity, enzyme activity loss, ion transport, protein synthesis suppression, protein cross-linking, DNA damage, etc., resulting in cell death. Redox homeostasis develops in plant cells as a result of equilibrium between the creations of ROS and the functioning of antioxidant enzymes, where a well-functioning defense system in plants maintains the right balance between ROS generation and its removal.
For proper redox signaling in the cell, it is, therefore, necessary to maintain an amount of ROS above or below the cytotoxic concentration, which is achieved by maintaining the equilibrium between ROS production and scavenging. As a result, a constant equilibrium between ROS formation and scavenging systems is maintained by cooperating with cellular redox-sensitive components to precisely adapt the downstream signaling procedures in a context-specific and cell-specific manner. Under varied abiotic stress conditions, any disruption in the equilibrium between ROS formation and scavenging by antioxidants leads to ROS excess buildup, culminating in oxidative stress [9]. Oxidative stress results in damaging the nucleic acid and protein and lipid peroxidation, thereby altering the carbohydrate metabolism and thus leading to cellular death and its dysfunction.
4.1 Lipids
Increasing ROS levels trigger lipid peroxidation in membranes of cells and organelles, affecting normal cellular activity. Oxidative stress is exacerbated by lipid peroxidation by producing radicals from lipids, which affect proteins and DNA. In stressed cells, lipid peroxidation can be used as a biomarker of ROS-mediated membrane damage. Environmental challenges have been shown to cause increased lipid peroxidation and its degradation in several plants [22].
4.2 Proteins
Besides direct changes, ROS can indirectly affect proteins. Direct modification is the process of modifying a protein’s function by disulfide bond formation, nitrosylation, carbonylation, and glutathionylation. Through the breakdown of fatty acid peroxidation products, proteins are indirectly altered. The increased ROS production alters amino acid sites, fragments peptide chains, aggregates cross-linked reactions, changes the charge, and increases the proteolytic activity of proteins. The amount of carbonylated proteins in oxidatively damaged tissues is higher, a measurement of protein oxidation. Plants are reported to modify proteins in response to diverse stressors. There is a wide range of ROS attacks that can be performed on amino acids in peptides [23, 24].
4.3 Damage to nucleotides and DNA
The hydroxyl radical (OH•) is one of the damaging factors for polynucleic acids, because it changes the pyrimidine and purine structure by liberating H+ from the C▬H bonds of methyl and 2-deoxyribose group, generating deoxyribose radical, thymine glycol, hydroxyl methyl urea, and other compounds, thereby breaking double-stranded DNA into single-stranded DNA. DNA damage is caused by oxidative stress. By oxidizing deoxyribose sugar, changing nucleotide bases, cross-linking DNA, proteins, and abstracting nucleotides, ROS cause DNA nucleotide damage. Plant growth, as well as development, is influenced by DNA damage through a variety of physiological mechanisms, including abnormal protein synthesis and damage to photosynthetic proteins, among others. It also can prevent replication mistakes, signal transduction, transcription, and overall genomic instability. In addition, DNA bases are damaged and irreversible not only by direct oxidation but also by reactive intermediates (associated with ROS attack) reacting with macromolecules [25, 26].
5. Oxidative stress under abiotic stress
There are different types of abiotic stresses as depicted in Figure 1.
Figure 1.
Different types of abiotic stresses for plants.
5.1 Oxidative stress under salinity
Among all above-mentioned abiotic stresses, salinity or salt stress is regarded as one of the most damaging, reducing land area and agricultural productivity. Soil salinity is a global issue that affects around 20% of irrigated land and severely lowers agricultural production [27]. Salinity has a negative impact on crop germination, yield, and vigor. Osmotic stress, nutritional ionic specificity, hormonal problems, altered physiological and metabolic processes, and, finally, oxidative damage occur when plants are exposed to high salt concentration. Some of the most typical effects of salt stress in plants are photosynthetic reduction, nutritional unavailability, cellular membrane disruption, the creation of several toxic metabolites, and eventual plant death.
Salinity stress causes overproduction of ROS that affects the plants leading to ion toxicity, nutritional inadequacy, osmotic stress, and genotoxicity that causes oxidative stress [28, 29].
5.2 Drought
Drought causes stomatal closure and decreases CO2 fixation in plant leaves. As a result, this stress causes an imbalance between light capture and utilization, lowering the photosynthetic rate [30]. During drought, the photochemistry of chloroplasts changes, and an imbalance between electron acceptance and release results in an increase in the formation of ROS from surplus light energy in the photosystems. In reality, ROS are produced by absorbed light energy, which cannot be converted to CO2 fixation. Photorespiration directly causes drought-induced H2O2 production. Furthermore, under drought stress, if chloroplasts are exposed to excessive light energy, ferredoxin levels plummet; NADP+ regeneration is hampered, interfering with electron uptake, resulting in lower ETC and increased electron leakage, both of which contribute to ROS overproduction. Drought-induced LPO, malondialdehyde (MDA), and H2O2 accumulation cause malfunction of several physiological and cellular processes including membrane functions, water-use efficiency, stomatal conductance, carboxylation efficiency, transpiration, respiration, and photosynthesis. Drought stress increases MDA and H2O2 levels in several plant species, including maize, chili, rapeseed, alfalfa, soybean, and others, which, along with other harmful ROS, cause oxidative damage [31].
5.3 Metal toxicity
Toxicity from metals or metalloids not only disrupts morphophysiological features but also causes increased oxidative stress due to an imbalance between the antioxidant defense system and ROS generation. In a study, it was found that nickel (100 M) stressed Pisum sativum L. seedlings accumulated more LPO and H2O2. Such increases in oxidative stress indicators were even greater in the same crop with the same Cd content. Meanwhile, cadmium stress increases the H2O2 and MDA production in numerous crops. Aside from H2O2 and MDA, the rate of O2• generation in Vigna radiata L. was also higher [5, 32].
5.4 Flooding or waterlogging
In the natural environment, unexpected extreme climate change occurs, such as flooding, which can disrupt the natural distribution of plants and even lead to extinction. Flooding or waterlogging (WL) can cause anoxia as well as hypoxia by impeding respiration and producing toxic chemicals that impede metabolic processes. The main reasons for yield reduction are decreased growth and production of biomass, disruption in light interception, limitation of stomatal conductance and CO2 assimilation, reduced respiration and photosynthesis, and altered accumulation of secondary metabolites. Under WL conditions, such metabolic process deficiencies result in the production of ROS and cause oxidative damage to the cell [33].
5.5 Chilling
Temperatures (1–10°C) in the chilling-sensitive plant’s cells cause multiple physiological abnormalities, resulting in chilling injury and mortality in many tropical and subtropical plant species, including many vegetable species. According to a recent study, exposing chilling-sensitive plants to low temperatures disrupts all physiological functions, including water regime, mineral feeding, photosynthesis, respiration, and metabolism [34]. The reported inactivation of metabolism during chilling of chilling-sensitive plants is a complicated function of both temperature and exposure period. Plants’ responses to low temperature are connected with changes in the rate of gene transcription of a variety of low-molecular-weight proteins.
Chilling stress denotes low-temperature harm without the development of ice crystals, whereas freezing stress denotes injury caused by ice formation within plant tissues. Plant species are dependable in their tolerance to chilling or freezing conditions. Chilling temperature decreases crop productivity by interfering with various components of plant growth and development. At the vegetative stage, freezing temperatures restrict seedling growth and create aberrant phenotypes, such as stem discoloration, leaf yellowing or whitening, white patches/spots, wilting, and diminished tillering. Mung bean seedling development and dry weight reduced when exposed to a chilling temperature of 6°C. These seedlings also have aberrant phenotypic characteristics. Cold (11°C) damage symptoms were detected in rice [35, 36]. In chill-affected rice plants, stunted development, leaf chlorosis, an uneven number of tillers, and deformed and discolored grain symptoms were common. Lower temperatures affected soybean growth time, biomass accumulation, harvested index, seed number, and seed weight [37].
5.6 Extremely high temperature
Rising global temperatures over the previous few decades have resulted in major crop losses in a variety of regions throughout the world. By the year 2100, global temperature is anticipated to rise by up to 2.5–5.4°C. Temperature intensity, duration, and rate of increase are all critical factors in causing plant damage. Some frequent damaging consequences of high temperature include reduced germination and biomass, increased tillering, chlorosis, necrosis, early senescence of floral buds, premature mortality, and fruit senescence. Heat stress during seed development causes structural disintegration and physiological problems, reducing germination and vigor, emergence, and seedling establishment even further. High temperatures hampered rice seed germination by lowering the levels of a collection of proteins involved in methionine metabolism, amino acid biosynthesis, energy metabolism, reserve degradation, and protein folding [38, 39].
5.7 Ultraviolet radiation
UV is a type of radiation that is produced by the sun. Solar radiation provides essential energy for plant growth and development through photosynthesis, but high light and, in particular, its integral ultraviolet (UV) fraction cause stress, potentially resulting in severe injury to plant cellular components such as DNA and protein.
The regular discharge of chlorofluorocarbons and other pollutants as a result of human activity increases the amount of UV radiation on the earth’s surface, which is the primary cause of stratospheric ozone layer depletion. Plants and animals are harmed as a result of stratospheric ozone depletion and increased solar UV radiation. Because sunlight is required for photosynthesis in terrestrial plants, they are most vulnerable to UV radiation [14, 40].
5.8 Herbicide toxicity
Herbicides are frequently used to control weeds in cultivated agricultural plants. Nonetheless, unintentional pesticide usage may cause oxidative stress in plants. Herbicides cause oxidative stress by producing too much ROS, which degrades plant photosynthetic pigments, lipids, cell membranes, and enzyme activity, affecting plant growth and production. Glyphosate, an herbicide, generated this stress in plants by limiting the shikimate pathway, resulting in excessive production of ROS and disruption of redox homeostasis. Glyphosate strongly hindered the growth of Hordeum vulgare L. (Barley) in response to larger accumulations of H2O2 and O2, which raised LPO [41, 42].
6. ROS defense machinery
This defense mechanism is comprised of antioxidant machinery, which aids in the mitigation of the above-mentioned oxidative stress-induced harms. The antioxidant machinery is composed of two arms: enzymatic components and nonenzymatic antioxidants (Figure 2) [43].
Figure 2.
Components of antioxidant defense mechanism.
6.1 Enzymatic antioxidants
Within the cellular and subcellular compartments, the antioxidant machinery is composed of several antioxidant enzymes such as superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase (POD), catalase (CAT), dehydroascorbate reductase (DHAR), guaiacol peroxidase (GPX), glutathione reductase (GR), and monodehydroascorbate reductase (MDHAR).
6.1.1 Superoxide dismutase (SOD)
All aerobic organisms contain the metalloenzyme SOD. This is the initial line of defense against ROS-induced damage under environmental stress. SOD catalyzes O2•− elimination by dismutating it into H2O2 and O2. This eliminates OH• generation as a result of the Haber-Weiss reaction. The SODs can be classified into three groups based on the metal ion they bind: Mn-SOD located in mitochondria, Cu/Zn-SOD located in cytosol, (chloroplasts and peroxisomes), and Fe-SOD localized in the chloroplasts. Under abiotic stress (including salinity), the SOD levels get increased, as plants tend to defend themselves from oxidative stress [21].
O2•−+O2•−+2H−→2H2O2+O2E1
6.1.2 Catalase (CAT)
It is a tetrameric heme enzyme that catalyzes the dismutation of H2O2 into O2 and H2O. It has a strong affinity for H2O2, but a weaker attraction for organic peroxides. It has a very rapid turnover rate and is unique among antioxidant enzymes in that it does not require a reducing counterpart. Peroxisomes are hotspots for H2O2 generation due to photorespiration, purine catabolism, fatty acid oxidation, and oxidative stress. Recent studies reveal that CAT is also located in other subcellular compartments including chloroplast, mitochondria, and cytosol; however, considerable CAT activity has yet to be observed. CAT eliminates H2O2 in an energy-efficient manner [21, 44]:
2H2O2→H2O+1/2O2E2
6.1.3 Ascorbate peroxidase (APX)
The ascorbate glutathione cycle (ASC-GSH) is driven by ascorbate peroxidase (APX). While CAT primarily scavenges H2O2 in the peroxisomes, APX does the same in the cytosol and chloroplast. The APX uses ascorbic acid (AA) as a reducing agent to convert H2O2 to H2O and DHA.
H2O2+AA→2H2O+DHAE3
The APX family is divided into five distinct isoforms depending on amino acid sequences and location, including chloroplastid (thylakoidal and stromal), mitochondrial, peroxisomal, and cytosolic. Because APX is more extensively distributed and has a higher affinity toward H2O2 than CAT, it is a more effective H2O2 scavenger during stress [45].
6.1.4 Monodehydroascorbate reductase (MDHAR)
It is in charge of regenerating AA from the short-lived MDHA by employing NADPH as a reducing agent and thus refilling the cellular AA pool. Because it regenerates AA, it colocalizes with APX in mitochondria and peroxisomes where APX scavenges H2O2 and oxidizes AA. MDHAR has several isozymes that are found in mitochondria, peroxisomes, chloroplasts, cytosol, and glyoxysomes [2, 46]:
MDHA+NADPH→AA+NADP+E4
6.1.5 Dehydroascorbate reductase (DHAR)
It uses reduced glutathione (GSH) as an e− donor to convert dehydroascorbate (DHA) to AA. This makes it, in addition to MDHAR, another drug that regenerates the cellular AA pool. It is essential for regulating the AA pool size in both apoplast and symplast, hence maintaining the plant cell’s redox status. DHAR can be detected in high concentrations in seeds, roots, and both green and etiolated shoots [47, 48].
DHA+2GSH→AA+GSSGE5
6.1.6 Glutathione reductase (GR)
It is a flavoprotein oxidoreductase that reduces GSSG to GSH using NADPH as a reductant. Reduced glutathione (GSH) is depleted when it is utilized to produce AA from DHA and MDHA, and it is thus transformed to its oxidized state (GSSG). To maintain a high cellular GSH/GSSG ratio, GR, a critical enzyme of the ASC-GSH cycle, catalyzes the creation of a disulfide bond in glutathione disulfide. It is mostly found in chloroplasts, with trace amounts being detected in cytoplasm and mitochondria. GSH is a low-molecular-weight molecule that acts as a reductant, preventing thiol groups from being oxidized and reacting with harmful ROS members [49, 50].
GSSG+NADPH→2GSH+NADP+E6
6.2 Nonenzymatic components of antioxidative defense system
The primary cellular redox buffers glutathione, ascorbate, phenols, carotenoids, and tocopherol that are nonenzymatic components of the antioxidative defense mechanism. Plant growth and development are influenced by numerous antioxidants that modulate several processes ranging from cell elongation and mitosis to senescence and cellular death. They not only protect various cell components from harm, but also play a significant role in plant growth, maturation, and development by modifying cellular processes such as mitosis, senescence, cell elongation, and cell death.
6.2.1 Ascorbate (AsA)
AsA is the most prevalent, low-molecular-weight antioxidant, and it plays an important role in the defense against oxidative stress induced by increased ROS levels. Because of its potential to donate e− in a variety of enzymatic and nonenzymatic processes, AsA is regarded as a potent antioxidant. AsA has been demonstrated to be involved in several physiological processes in plants. The majority of AsA, about 90%, is found in the cytoplasm, but unlike other soluble antioxidants, a significant fraction is transported to the apoplast. The first line of defense in apoplastic AsA is thought to be against potentially harmful exogenous oxidants. AsA shields important macromolecules from oxidative degradation. Under normal physiological conditions, AsA is usually found in a reduced state in chloroplasts. It protects the membrane by directly interacting with H2O2, O2•, producing tocopherol from tocopheroxyl radicals, and preserving the activities of enzymes containing prosthetic transition metal ions. AsA plays a beneficial role in the elimination of H2O2via the AsAGSH cycle [51, 52].
6.2.2 Glutathione
Glutathione tripeptide (−glutamylcysteinyl-glycine, GSH) is a critical low-molecular-weight nonprotein thiol that plays a significant role in intracellular defense action against ROS-induced oxidative damage. It has been documented in almost every cell compartment, including the chloroplasts, cytosol, vacuoles, endoplasmic reticulum, and mitochondria. GSH is produced in plant cells, chloroplasts, and cytosol, by compartment-specific isoforms of glutathione synthetase and glutamylcysteinyl synthetase. The balance of glutathione disulfide (GSSG) and GSH is essential for sustaining cellular redox state. A variety of biological processes depend on GSH’s reducing abilities, including cell growth/division, sulfate transport regulation, metabolite conjugation, signal transduction, enzymatic regulation, nucleic acid and protein synthesis, xenobiotic detoxification, synthesis of phytochelatins, and stress-responsive gene expression. GSH acts as an antioxidant in several ways. It can chemically react with OH•, O2•−, and H2O2 and hence work directly as a free radical scavenger. GSH can protect macromolecules (proteins, lipids, and DNA) by directly forming adducts with reactive electrophiles [53].
6.2.3 Tocopherols
Tocopherols are a class of lipophilic antioxidants that scavenge oxygen-free radicals, lipid peroxy radicals, and 1O2. The relative antioxidant activities of the tocopherol isomers α-, β-, γ-, and δ- are related to the number of methyl groups and methylation pattern that are connected to the phenolic ring of the polar head structure. As a result, tocopherol has the highest antioxidant activity due to its three methyl substituents. Tocopherols are only generated by photosynthetic organisms and are found only in the green portions of plants. As precursors, the tocopherol biosynthesis pathway uses two compounds: homogentisic acid (HGA) and phytyl diphosphate (PDP). Tocopherols inhibit the chain propagation stage in lipid autoxidation, making them an efficient free radical trap. In redox interactions with 1O2, tocopherol’s fully substituted benzoquinone ring and fully reduced phytyl chain operate as antioxidants [54].
6.2.4 Carotenoids
Carotenoids are lipophilic antioxidants capable of detoxifying several kinds of ROS. Carotenoids can be found in both plants and microbes. During the visible range between 400 and 550 nm, carotenoids absorb light and transmit it to the chloroplast. They act as an antioxidant by scavenging 1O2 to avoid oxidative damage and quenching triplet sensitizer (3Chl) and excited chlorophyll (Chl) molecules to prevent the creation of 1O2 and therefore protect the photosynthetic system. Carotenoids are also the precursors of several signaling molecules, which regulate various biotic/abiotic stress responses and plant development. Carotenoids’ ability to scavenge, inhibit, or reduce the formation of triplet chlorophyll may be explained by their chemical specificity. Carotenoids comprise a chain of isoprene residues with many conjugated double bonds, allowing for simple energy intake from excited molecules and heat dissipation [55].
6.2.5 Phenolic compounds
These are the group of secondary metabolites with antioxidant capabilities that include tannins, flavonoids, lignin, and hydroxycinnamate esters. They are abundant in plant tissues. Polyphenols have an aromatic ring with ▬OH or OCH3 substituents that contribute to their biological activity, which includes an antioxidant activity. In addition to chelating transition metal ions, polyphenols absorb molecular species of active oxygen and inhibit lipid peroxidation by scavenging lipid alkoxyl radicals. They also change the lipid packing order and reduce membrane fluidity. These modifications may severely hamper free radical transport and limit peroxidative processes. Furthermore, it has been demonstrated that flavonoids and phenylpropanoids, in particular, are oxidized by peroxidase and act in an H2O2-scavenging, phenolic system [56].
6.2.6 Proline
Proline, an osmolyte, is also considered a potent antioxidant. It is frequently employed as a nonenzymatic antioxidant across various kingdoms to combat the detrimental effects of various ROS members. This is produced from glutamic acid via a pyrroline 5-carboxylate intermediate. This route is mediated in plants by two enzymes, pyrroline-5-carboxylate reductase and 1-pyrroline-5-carboxylate synthetase. It is an effective OH• and 1O2 scavenger and can prevent LPO damage. Proline accumulates in huge concentrations in plants during stress, either due to increased synthesis or due to decreased breakdown [57].
7. Conclusion
ROS have long been known to play an important role in controlling plant responses to both biotic and abiotic stressors. They are unavoidable harmful metabolic byproducts that serve as signaling molecules under stress situations. Although ROS appear to be damage agents in plants, their importance in boosting the stress signaling component to prevent future losses is also noteworthy. Despite the constant increase in stress-related publications, there is no novelty in the content. ROS has a dual purpose: it is an unavoidable byproduct of aerobic metabolism, on the one hand, and it serves as a marker during stressful conditions, on the other hand. They not only act as damage agents in plants but also activate stress-signaling components to prevent future harm. ROS synthesis is extensive, with production sites found both intracellularly and extracellularly. ROS causes severe damage, and its targets include all biomolecules such as DNA, proteins, and lipids compromising the cell’s integrity and ultimately leading to death. This chapter explains how both components of the antioxidant machinery, antioxidant enzymes and non-antioxidant metabolites work together to mitigate the harmful effects of ROS and build a tolerance to diverse environmental stress situations. Despite substantial advances in recent years, there are still uncertainties and gaps in our knowledge of ROS production and how they influence plants, owing to their short half-life and highly reactive nature. Although the highly compartmentalized nature of antioxidants is well understood, the sensing and response mechanisms, as well as the regulation of the delicate balance between production and scavenging, require more investigation. In the future, molecular research might lead to a better understanding of ROS metabolism. Advanced functional genomics, in conjunction with proteomics and metabolomics, will provide extensive insights into the ROS network and its associated reactions.
Acknowledgments
The authors are grateful to DST FIST and Department of Bioscience, Integral University, Lucknow, Uttar Pradesh, India.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"ROS, abiotic stress, antioxidant, free radical",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/79235.pdf",chapterXML:"https://mts.intechopen.com/source/xml/79235.xml",downloadPdfUrl:"/chapter/pdf-download/79235",previewPdfUrl:"/chapter/pdf-preview/79235",totalDownloads:139,totalViews:0,totalCrossrefCites:2,dateSubmitted:null,dateReviewed:"October 3rd 2021",datePrePublished:"December 23rd 2021",datePublished:"April 28th 2022",dateFinished:"November 3rd 2021",readingETA:"0",abstract:"The antioxidant potential is referred to as compounds that are capable of protecting the biological system against the deleterious effect of reactions involving reactive oxygen species (ROS). ROS are toxic byproducts of oxygen metabolism. ROS have a significant role in plant signaling, growth, development, and majorly in response to environmental fluctuations. The ROS family plays a double role under various environmental stress conditions. In various key physiological phenomena, they act as secondary messengers and induce oxidative damage. ROS led to cellular damages that manifest themselves in degradation of biomolecules, which eventually amalgamate to cellular death in plants. To assure survival, plants have developed efficient antioxidant machinery having two branches, that is, an enzymatic and a nonenzymatic antioxidant. This chapter will emphasize the various types of ROS, their sites of cellular production, targets, and scavenging mechanisms mediated by antioxidants in abiotic stress. Such profound knowledge will let us build strategies against environmental stress.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/79235",risUrl:"/chapter/ris/79235",signatures:"Ambreen Bano, Anmol Gupta, Smita Rai, Touseef Fatima, Swati Sharma and Neelam Pathak",book:{id:"10795",type:"book",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",fullTitle:"Plant Stress Physiology - Perspectives in Agriculture",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-867-5",printIsbn:"978-1-83969-866-8",pdfIsbn:"978-1-83969-868-2",isAvailableForWebshopOrdering:!0,editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"423323",title:"Ms.",name:"Ambreen",middleName:null,surname:"Bano",fullName:"Ambreen Bano",slug:"ambreen-bano",email:"ambreenbano2408@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"423365",title:"Mr.",name:"Anmol",middleName:null,surname:"Gupta",fullName:"Anmol Gupta",slug:"anmol-gupta",email:"anmolgupta632@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"423817",title:"Prof.",name:"Neelam",middleName:null,surname:"Pathak",fullName:"Neelam Pathak",slug:"neelam-pathak",email:"pathak.neelam007@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",fullName:"Smita Rai",slug:"smita-rai",email:"shiblyrai@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Integral University",institutionURL:null,country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",fullName:"Swati Sharma",slug:"swati-sharma",email:"sw_sh@rediffmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Integral University",institutionURL:null,country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",fullName:"Touseef Fatima",slug:"touseef-fatima",email:"taus.fatima@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Integral University",institutionURL:null,country:{name:"India"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Types of ROS",level:"2"},{id:"sec_1_3",title:"1.1.1 Superoxide radical (O2•−)",level:"3"},{id:"sec_2_3",title:"1.1.2 Singlet oxygen (1O2)",level:"3"},{id:"sec_3_3",title:"1.1.3 Hydrogen peroxide (H2O2)",level:"3"},{id:"sec_4_3",title:"1.1.4 Hydroxyl radical (OH•)",level:"3"},{id:"sec_5_3",title:"1.1.5 Peroxyl radical (ROO•)",level:"3"},{id:"sec_6_3",title:"1.1.6 Alkoxy radical (RO•)",level:"3"},{id:"sec_9",title:"2. Sites of ROS production/generation in plant cells",level:"1"},{id:"sec_9_2",title:"2.1 Chloroplast",level:"2"},{id:"sec_10_2",title:"2.2 Mitochondria",level:"2"},{id:"sec_11_2",title:"2.3 Apoplast",level:"2"},{id:"sec_12_2",title:"2.4 Plasma membranes",level:"2"},{id:"sec_13_2",title:"2.5 Cell walls",level:"2"},{id:"sec_14_2",title:"2.6 Endoplasmic reticulum (ER)",level:"2"},{id:"sec_16",title:"3. Role of ROS as messengers",level:"1"},{id:"sec_17",title:"4. ROS and oxidative damage to biomolecules",level:"1"},{id:"sec_17_2",title:"4.1 Lipids",level:"2"},{id:"sec_18_2",title:"4.2 Proteins",level:"2"},{id:"sec_19_2",title:"4.3 Damage to nucleotides and DNA",level:"2"},{id:"sec_21",title:"5. Oxidative stress under abiotic stress",level:"1"},{id:"sec_21_2",title:"5.1 Oxidative stress under salinity",level:"2"},{id:"sec_22_2",title:"5.2 Drought",level:"2"},{id:"sec_23_2",title:"5.3 Metal toxicity",level:"2"},{id:"sec_24_2",title:"5.4 Flooding or waterlogging",level:"2"},{id:"sec_25_2",title:"5.5 Chilling",level:"2"},{id:"sec_26_2",title:"5.6 Extremely high temperature",level:"2"},{id:"sec_27_2",title:"5.7 Ultraviolet radiation",level:"2"},{id:"sec_28_2",title:"5.8 Herbicide toxicity",level:"2"},{id:"sec_30",title:"6. ROS defense machinery",level:"1"},{id:"sec_30_2",title:"6.1 Enzymatic antioxidants",level:"2"},{id:"sec_30_3",title:"6.1.1 Superoxide dismutase (SOD)",level:"3"},{id:"sec_31_3",title:"6.1.2 Catalase (CAT)",level:"3"},{id:"sec_32_3",title:"6.1.3 Ascorbate peroxidase (APX)",level:"3"},{id:"sec_33_3",title:"6.1.4 Monodehydroascorbate reductase (MDHAR)",level:"3"},{id:"sec_34_3",title:"6.1.5 Dehydroascorbate reductase (DHAR)",level:"3"},{id:"sec_35_3",title:"6.1.6 Glutathione reductase (GR)",level:"3"},{id:"sec_37_2",title:"6.2 Nonenzymatic components of antioxidative defense system",level:"2"},{id:"sec_37_3",title:"6.2.1 Ascorbate (AsA)",level:"3"},{id:"sec_38_3",title:"6.2.2 Glutathione",level:"3"},{id:"sec_39_3",title:"6.2.3 Tocopherols",level:"3"},{id:"sec_40_3",title:"6.2.4 Carotenoids",level:"3"},{id:"sec_41_3",title:"6.2.5 Phenolic compounds",level:"3"},{id:"sec_42_3",title:"6.2.6 Proline",level:"3"},{id:"sec_45",title:"7. Conclusion",level:"1"},{id:"sec_46",title:"Acknowledgments",level:"1"},{id:"sec_49",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Foyer CH, Noctor G. Redox regulation in photosynthetic organisms: Signaling, acclimation, and practical implications. Antioxidants & Redox Signaling. 2009;11(4):861-905'},{id:"B2",body:'Kapoor D, Bhardwaj S, Landi M, Sharma A, Ramakrishnan M, Sharma A. The impact of drought in plant metabolism: How to exploit tolerance mechanisms to increase crop production. Applied Sciences. 2020;10(16):5692'},{id:"B3",body:'Suzuki N, Koussevitzky SH, Mittler RO, Miller GA. ROS and redox signalling in the response of plants to abiotic stress. Plant, Cell & Environment. 2012;35(2):259-270'},{id:"B4",body:'Sachdev S, Ansari SA, Ansari MI, Fujita M, Hasanuzzaman M. Abiotic stress and reactive oxygen species: Generation, signaling, and defense mechanisms. Antioxidants. 2021;10(2):277'},{id:"B5",body:'Hasanuzzaman M, Bhuyan MH, Zulfiqar F, Raza A, Mohsin SM, Mahmud JA, et al. Reactive oxygen species and antioxidant defense in plants under abiotic stress: Revisiting the crucial role of a universal defense regulator. Antioxidants. 2020;9(8):681'},{id:"B6",body:'Mehla N, Sindhi V, Josula D, Bisht P, Wani SH. An introduction to antioxidants and their roles in plant stress tolerance. In: Reactive Oxygen Species and Antioxidant Systems in Plants: Role and Regulation under Abiotic Stress. Singapore: Springer; 2017. pp. 1-23'},{id:"B7",body:'Singh A, Kumar A, Yadav S, Singh IK. Reactive oxygen species-mediated signaling during abiotic stress. Plant Gene. 2019;18:100173'},{id:"B8",body:'Raja V, Majeed U, Kang H, Andrabi KI, John R. Abiotic stress: Interplay between ROS, hormones and MAPKs. Environmental and Experimental Botany. 2017;137:142-157'},{id:"B9",body:'Kuluev B, Mikhaylova E, Berezhneva Z, Nikonorov Y, Postrigan B, Kudoyarova G, et al. Expression profiles and hormonal regulation of tobacco NtEXGT gene and its involvement in abiotic stress response. Plant Physiology and Biochemistry. 2017;111:203-215'},{id:"B10",body:'Halliwell B, Gutteridge JM. Free Radicals in Biology and Medicine. USA: Oxford University Press; 2015'},{id:"B11",body:'Krieger-Liszkay A, Fufezan C, Trebst A. Singlet oxygen production in photosystem II and related protection mechanism. Photosynthesis Research. 2008;98(1):551-564'},{id:"B12",body:'Noctor G, Veljovic-Jovanovic SO, Driscoll S, Novitskaya L, Foyer CH. Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration? Annals of Botany. 2002;89(7):841-850'},{id:"B13",body:'Pint BA. Experimental observations in support of the dynamic-segregation theory to explain the reactive-element effect. Oxidation of Metals. 1996;45(1):1-37'},{id:"B14",body:'Miller GA, Suzuki N, Ciftci-Yilmaz SU, Mittler RO. Reactive oxygen species homeostasis and signalling during drought and salinity stresses. Plant, Cell & Environment. 2010;33(4):453-467'},{id:"B15",body:'Mignolet-Spruyt L, Xu E, Idänheimo N, Hoeberichts FA, Mühlenbock P, Brosché M, et al. Spreading the news: Subcellular and organellar reactive oxygen species production and signalling. Journal of Experimental Botany. 2016;67(13):3831-3844'},{id:"B16",body:'Noctor G, De Paepe R, Foyer CH. Mitochondrial redox biology and homeostasis in plants. Trends in Plant Science. 2007;12(3):125-134'},{id:"B17",body:'Pastore D, Trono D, Laus MN, Di Fonzo N, Flagella Z. Possible plant mitochondria involvement in cell adaptation to drought stress: A case study: Durum wheat mitochondria. Journal of Experimental Botany. 2007;58(2):195-210'},{id:"B18",body:'Hu X, Zhang A, Zhang J, Jiang M. Abscisic acid is a key inducer of hydrogen peroxide production in leaves of maize plants exposed to water stress. Plant and Cell Physiology. 2006;47(11):1484-1495'},{id:"B19",body:'Eaton CJ, Jourdain I, Foster SJ, Hyams JS, Scott B. Functional analysis of a fungal endophyte stress-activated MAP kinase. Current Genetics. 2008;53(3):163-174'},{id:"B20",body:'Higuchi T. Look back over the studies of lignin biochemistry. Journal of Wood Science. 2006;52(1):2-8'},{id:"B21",body:'Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends in Plant Science. 2002;7(9):405-410'},{id:"B22",body:'Yadu B, Chandrakar V, Keshavkant S. Responses of plants to fluoride: an overview of oxidative stress and defense mechanisms. Fluoride. 2016;49(3):293'},{id:"B23",body:'Hu WH, Song XS, Shi K, Xia XJ, Zhou YH, Yu JQ. Changes in electron transport, superoxide dismutase and ascorbate peroxidase isoenzymes in chloroplasts and mitochondria of cucumber leaves as influenced by chilling. Photosynthetica. 2008;46(4):581-588'},{id:"B24",body:'Moller IM, Kristensen BK. Protein oxidation in plant mitochondria as a stress indicator. Photochemical & Photobiological Sciences. 2004;3(8):730-735'},{id:"B25",body:'Baker A, Graham IA, editors. Plant Peroxisomes: Biochemistry, Cell Biology and Biotechnological Applications. Netherlands: Springer Science & Business Media; 2013'},{id:"B26",body:'Yan J, Tsuichihara N, Etoh T, Iwai S. Reactive oxygen species and nitric oxide are involved in ABA inhibition of stomatal opening. Plant, Cell & Environment. 2007;30(10):1320-1325'},{id:"B27",body:'Negrao S, Schmöckel SM, Tester M. Evaluating physiological responses of plants to salinity stress. Annals of Botany. 2017;119(1):1-1'},{id:"B28",body:'Gupta A, Rai S, Bano A, Khanam A, Sharma S, Pathak N. Comparative Evaluation of Different Salt-Tolerant Plant Growth-Promoting Bacterial Isolates in Mitigating the Induced Adverse Effect of Salinity in Pisum sativum. 2021;11'},{id:"B29",body:'Chourasia KN, Lal MK, Tiwari RK, Dev D, Kardile HB, Patil VU, et al. Salinity stress in Potato: Understanding physiological, biochemical and molecular responses. Life. 2021;11(6):545'},{id:"B30",body:'Sperdouli I, Moustakas M. Interaction of proline, sugars, and anthocyanins during photosynthetic acclimation of Arabidopsis thaliana to drought stress. Journal of Plant Physiology. 2012;169(6):577-585'},{id:"B31",body:'Cruz de Carvalho MH. Drought stress and reactive oxygen species: Production, scavenging and signaling. Plant Signaling & Behavior. 2008;3(3):156-165'},{id:"B32",body:'Bhaduri AM, Fulekar MH. Antioxidant enzyme responses of plants to heavy metal stress. Reviews in Environmental Science and Bio/Technology. 2012;11(1):55-69'},{id:"B33",body:'Ashraf MA. Waterlogging stress in plants: A review. African Journal of Agricultural Research. 2012;7(13):1976-1981'},{id:"B34",body:'Patterson BD, Payne LA, Chen YZ, Graham D. An inhibitor of catalase induced by cold in chilling-sensitive plants. Plant Physiology. 1984;76(4):1014-1018'},{id:"B35",body:'Nahar K, Hasanuzzaman M, Alam M, Fujita M. Exogenous spermidine alleviates low temperature injury in mung bean (Vigna radiata L.) seedlings by modulating ascorbate-glutathione and glyoxalase pathway. International Journal of Molecular Sciences. 2015;16(12):30117-30132'},{id:"B36",body:'Dar MA, Reshi ZA. Induced genotoxicity and oxidative stress in plants: An overview. Induced Genotoxicity and Oxidative Stress in Plants. 2021;1:1-27'},{id:"B37",body:'Nahar K, Hasanuzzaman M. Germination, growth, nodulation and yield performance of three mungbean varieties under different levels of salinity stress. Green Farming. 2009;2(12):825-829'},{id:"B38",body:'Zhu WJ, Li PP, Xue CM, Chen M, Wang Z, Yang Q. Potato plants overexpressing SpHsfA4c exhibit enhanced tolerance to high-temperature stress Russian Journal of Plant Physiology 2021:1-0'},{id:"B39",body:'Sonkar S, Singh AK, Husen A. Functions of hydrogen sulfide in plant regulation and response to abiotic stress. In: Plant Performance Under Environmental Stress. Champions: Springer; 2021. pp. 329-355'},{id:"B40",body:'Jeena AS, Pandey D. Metal induced genotoxicity and oxidative stress in plants, assessment methods, and role of various factors in genotoxicity regulation. In: Induced Genotoxicity and Oxidative Stress in Plants. Singapore: Springer; 2021. pp. 133-149'},{id:"B41",body:'Bela K, Horváth E, Gallé Á, Szabados L, Tari I, Csiszár J. Plant glutathione peroxidases: Emerging role of the antioxidant enzymes in plant development and stress responses. Journal of Plant Physiology. 2015;176:192-201'},{id:"B42",body:'Caverzan A, Piasecki C, Chavarria G, Stewart CN, Vargas L. Defenses against ROS in crops and weeds: The effects of interference and herbicides. International Journal of Molecular Sciences. 2019;20(5):1086'},{id:"B43",body:'Bano A, Gupta A, Rai S, Sharma S, Pathak N. Elucidation of bioactive potential of two commonly grown north Indian Psidium guajava viz. Lalit and Shweta against Pathogenic Foodborne and MDR Bacteria. 2021;11(6):14090-14102'},{id:"B44",body:'Zimmermann PE, Zentgraf UL. The correlation between oxidative stress and leaf senescence during plant development. Cellular and Molecular Biology Letters. 2005;10(3):515'},{id:"B45",body:'Sharma P, Dubey RS. Ascorbate peroxidase from rice seedlings: properties of enzyme isoforms, effects of stresses and protective roles of osmolytes. Plant Science. 2004;167(3):541-550'},{id:"B46",body:'Stevens R, Page D, Gouble B, Garchery C, Zamir D, Causse M. Tomato fruit ascorbic acid content is linked with monodehydroascorbate reductase activity and tolerance to chilling stress. Plant, Cell & Environment. 2008;31(8):1086-1096'},{id:"B47",body:'Eltayeb AE, Kawano N, Badawi GH, Kaminaka H, Sanekata T, Shibahara T, et al. Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses. Planta. 2007;225(5):1255-1264'},{id:"B48",body:'Chen Z, Gallie DR. Dehydroascorbate reductase affects leaf growth, development, and function. Plant Physiology. 2006;142(2):775-787'},{id:"B49",body:'Karuppanapandian T, Moon JC, Kim C, Manoharan K, Kim W. Reactive oxygen species in plants: Their generation, signal transduction, and scavenging mechanisms. Australian Journal of Crop Science. 2011;5(6):709-725'},{id:"B50",body:'Gill SS, Anjum NA, Hasanuzzaman M, Gill R, Trivedi DK, Ahmad I, et al. Glutathione and glutathione reductase: A boon in disguise for plant abiotic stress defense operations. Plant Physiology and Biochemistry. 2013;70:204-212'},{id:"B51",body:'Smirnoff N. Ascorbic acid: Metabolism and functions of a multi-facetted molecule. Current Opinion in Plant Biology. 2000;3(3):229-235'},{id:"B52",body:'Barnes J, Zheng Y, Lyons T. Plant resistance to ozone: The role of ascorbate. In: Air Pollution and Plant Biotechnology. Tokyo: Springer; 2002. pp. 235-252'},{id:"B53",body:'Foyer CH, Lopez-Delgado H, Dat JF, Scott IM. Hydrogen peroxide- and glutathione-associated mechanisms of acclimatory stress tolerance and signalling. Physiologia Plantarum. 1997;100(2):241-254'},{id:"B54",body:'Kamal-Eldin A, Appelqvist LÅ. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids. 1996;31(7):671-701'},{id:"B55",body:'Li F, Vallabhaneni R, Yu J, Rocheford T, Wurtzel ET. The maize phytoene synthase gene family: Overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiology. 2008;147(3):1334-1346'},{id:"B56",body:'Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF. Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties. Seminars in Cancer Biology. 2007;17(5):370-376'},{id:"B57",body:'Nathalie V, Christian H. Proline accumulation in plants: A review. Amino Acids. 2008;35(4):753-759'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ambreen Bano",address:"ambreenbano2408@gmail.com",affiliation:'
IIRC-3, Plant-Microbe Interaction and Molecular Immunology Laboratory, Department of Biosciences, Faculty of Sciences, Integral University, India
Department of Biochemistry, Dr. Rammanohar Lohia Avadh University, India
'}],corrections:null},book:{id:"10795",type:"book",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",fullTitle:"Plant Stress Physiology - Perspectives in Agriculture",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-867-5",printIsbn:"978-1-83969-866-8",pdfIsbn:"978-1-83969-868-2",isAvailableForWebshopOrdering:!0,editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"243375",title:"Ph.D.",name:"Luong Hai",middleName:null,surname:"Nguyen",email:"hainl@utc.edu.vn",fullName:"Luong Hai Nguyen",slug:"luong-hai-nguyen",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"62016",title:"Project Organizational Culture Framework in Construction Industry",slug:"project-organizational-culture-framework-in-construction-industry",abstract:"Project organizational culture (POC) has been recognized as a significant influencing factor of the success or failure of a project. Although numerous studies on this topic have been conducted to develop organizational culture models, these have mainly been for generic business settings, and one has not yet been developed for construction organizations at the project level. The aim of this chapter was to perform this task in Vietnam. A case study shows that cultural artifacts were arranged into a five-factor project organizational culture framework: “Project goal setting,” “Contractor assurance,” “Cooperative emphasis,” “Empowerment assignment,” and “Workforce emphasis.” The chapter’s findings suggest that the construction contracting organizations are more focused on the culture of mission and adaptability, with a relatively higher emphasis on clear project goals and contractor assurance. They favored a culture of involvement less, with a relatively lower emphasis on empowerment and workforce.",signatures:"Luong Hai Nguyen and Tsunemi Watanabe",authors:[{id:"243375",title:"Ph.D.",name:"Luong Hai",surname:"Nguyen",fullName:"Luong Hai Nguyen",slug:"luong-hai-nguyen",email:"hainl@utc.edu.vn"},{id:"243408",title:"Prof.",name:"Tsunemi",surname:"Watanabe",fullName:"Tsunemi Watanabe",slug:"tsunemi-watanabe",email:"watanabe.tsunemi@kochi-tech.ac.jp"}],book:{id:"7251",title:"Organizational Culture",slug:"organizational-culture",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"179629",title:"Prof.",name:"Jolita",surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/179629/images/system/179629.jpg",biography:"Prof. dr. Jolita Vveinhardt – a chief researcher of the Vytautas Magnus University, a professor at the Management Department of the Faculty of Economics and Management at the Vytautas Magnus University (Lithuania). The scientist is heading three scientific groups: 'Neuro-Relationships” (Lithuanian Sports University (LSU)), 'Managerial Solutions to Violence in Sport” (LSU), 'The Group of Interdisciplinary Research on Working Environment” (Vytautas Magnus University (VMU)). Jolita Vveinhardt is the author and co-author of three monographs, four scientific studies, one textbook, and five educational books. The scientist is the editor of three books published by InTech publishing house 'Congruence of Personal and Organizational Values” 2017, 'Organizational Culture” 2018, 'Management Culture and Corporate Social Responsibility” 2018). For the past several years she explores the phenomena of mobbing and nepotism, climate of the organisation and other aspects related to human resource management. She has published more than 200 scientific articles, 90 of which were published in peer reviewed journals of Web of Science Core Collection (Clarivate Analytics) database and read more than 50 papers in national and international scientific conferences. She is a member of editorial boards of 14 scientific periodicals. Prof. Dr. Jolita Vveinhardt is a member of 15 associations and societies. She teaches the following subjects for Master’s degree programme students: Contemporary Organization Theories (VMU) and Novelties of Management Science (LSU). Her main research interests are destructive relationships among employees (mobbing, bullying, nepotism, favouritism, social loafing, social ostracism, organizational cynicism, cronyism, protectionism), business ethics, organizational culture, management culture, organizational climate, personal and organizational values, value congruence, corporate social responsibility, decision-making, neuromanagement, etc.",institutionString:"Vytautas Magnus University",institution:{name:"Vytautas Magnus University",institutionURL:null,country:{name:"Lithuania"}}},{id:"195432",title:"Dr.",name:"Riaz",surname:"Ahmed",slug:"riaz-ahmed",fullName:"Riaz Ahmed",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bahria University",institutionURL:null,country:{name:"Pakistan"}}},{id:"243408",title:"Prof.",name:"Tsunemi",surname:"Watanabe",slug:"tsunemi-watanabe",fullName:"Tsunemi Watanabe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kochi University of Technology",institutionURL:null,country:{name:"Japan"}}},{id:"246109",title:"Dr.",name:"Saniye",surname:"Çelik",slug:"saniye-celik",fullName:"Saniye Çelik",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"246557",title:"Ph.D.",name:"Ivana",surname:"Šandrk Nukić",slug:"ivana-sandrk-nukic",fullName:"Ivana Šandrk Nukić",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"246628",title:"Dr.",name:"Andrey",surname:"Morozenko",slug:"andrey-morozenko",fullName:"Andrey Morozenko",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"247709",title:"Prof.",name:"Mohammad",surname:"Khan",slug:"mohammad-khan",fullName:"Mohammad Khan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"247712",title:"Prof.",name:"Laurie Smith",surname:"Law",slug:"laurie-smith-law",fullName:"Laurie Smith Law",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"247967",title:"Dr.",name:"Julia",surname:"Naranjo-Valencia",slug:"julia-naranjo-valencia",fullName:"Julia Naranjo-Valencia",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"260915",title:"Dr.",name:"Gregorio",surname:"Calderon-Hernández",slug:"gregorio-calderon-hernandez",fullName:"Gregorio Calderon-Hernández",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"attribution-policy",title:"Attribution Policy",intro:"
Definition of Terms:
\n\n
Book - collection of Works distributed in a book format, whose selection, coordination, preparation, and arrangement has been performed and published by IntechOpen, and in which the Work is included in its entirety in an unmodified form along with one or more other contributions, each constituting separate and independent sections, but together assembled into a collective whole.
",metaTitle:"Attribution Policy",metaDescription:"DEFINITION OF TERMS",metaKeywords:null,canonicalURL:"/page/attribution-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"
Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
\\n\\n
Attribution – appropriate credit for the used Work or book.
\\n\\n
Creative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
\\n\\n
Rules of Attribution for Works Published by IntechOpen
\\n\\n
With the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
\\n\\n
\\n\\t
All Chapters published in IntechOpen books prior to October 2011 are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license (CC BY-NC-SA 3.0);
\\n\\t
All Chapters published in IntechOpen books after October 2011 are licensed under the Creative Commons Attribution 3.0 Unported license (CC BY 3.0);
\\n
\\n\\n
In case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
\\n\\n
1. Rules for reusing of books in their entirety or significant parts of books
\\n\\n
All rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
\\n\\n
A Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
\\n\\n
In instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
\\n\\n
\\n\\t
Information about the first publisher must be provided – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) publication must be acknowledged;
\\n\\t
All original Academic Editor(s) must be credited;
\\n\\t
Since you are reusing content that someone else created and allowed you to use freely, you must credit all Authors involved;
\\n\\t
The type of license that is available for the Works must be indicated, as well as a link to the license provided, so that others can investigate the terms of the license. You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\\n\\t
Any original Copyright Notices associated, with the Works which constitute the Book must be kept intact;
\\n\\t
Provision of the original title of the Book, as well as the original titles of any individual Works;
\\n\\t
Provision of the URL where the Book is hosted, with a notice to the effect that the Book is an OA (Open Access) publication;
\\n\\t
Provision of the URL to every individual Work which constitutes the Book with a notice that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free.
\\n
\\n\\n
Every single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
\\n\\n
2. Rules of attribution for works published by IntechOpen
\\n\\n
Individual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\\n\\n
\\n\\t
Credit all Authors – since you are reusing contents that someone created and allowed you to use freely, you have to acknowledge authorship;
\\n\\t
Indicate the type of license under which the Work is available and provide the URL to the license so others can find out the license terms. Preferably keep intact any original Copyright Notice associated with the Chapter (if any). You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\\n\\t
Provide the URL where the Work is hosted, preferably providing the original title of the Work, as well as the original title of the Book with a notification that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free;
\\n\\t
Provide information about the first publisher – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) Work must be acknowledged.
\\n
\\n\\n
Every single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
\\n\\n
In the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\\n\\n
IntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\\n\\n
All these rules apply to BOTH online and offline use.
\\n\\n
Parts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\\n\\n
All the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
\n\n
Attribution – appropriate credit for the used Work or book.
\n\n
Creative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
\n\n
Rules of Attribution for Works Published by IntechOpen
\n\n
With the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
\n\n
\n\t
All Chapters published in IntechOpen books prior to October 2011 are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license (CC BY-NC-SA 3.0);
\n\t
All Chapters published in IntechOpen books after October 2011 are licensed under the Creative Commons Attribution 3.0 Unported license (CC BY 3.0);
\n
\n\n
In case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
\n\n
1. Rules for reusing of books in their entirety or significant parts of books
\n\n
All rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
\n\n
A Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
\n\n
In instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
\n\n
\n\t
Information about the first publisher must be provided – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) publication must be acknowledged;
\n\t
All original Academic Editor(s) must be credited;
\n\t
Since you are reusing content that someone else created and allowed you to use freely, you must credit all Authors involved;
\n\t
The type of license that is available for the Works must be indicated, as well as a link to the license provided, so that others can investigate the terms of the license. You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\n\t
Any original Copyright Notices associated, with the Works which constitute the Book must be kept intact;
\n\t
Provision of the original title of the Book, as well as the original titles of any individual Works;
\n\t
Provision of the URL where the Book is hosted, with a notice to the effect that the Book is an OA (Open Access) publication;
\n\t
Provision of the URL to every individual Work which constitutes the Book with a notice that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free.
\n
\n\n
Every single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
\n\n
2. Rules of attribution for works published by IntechOpen
\n\n
Individual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\n\n
\n\t
Credit all Authors – since you are reusing contents that someone created and allowed you to use freely, you have to acknowledge authorship;
\n\t
Indicate the type of license under which the Work is available and provide the URL to the license so others can find out the license terms. Preferably keep intact any original Copyright Notice associated with the Chapter (if any). You will be aware that the material can be used for free in consequence of the CC license attribution, so you must acknowledge that fact. It is not sufficient that the material is Creative Commons, because that says nothing about how the material can actually be used. There are different CC licenses and you have to identify the specific license that is being used;
\n\t
Provide the URL where the Work is hosted, preferably providing the original title of the Work, as well as the original title of the Book with a notification that the Work is an OA (Open Access) publication. As the material has been accessed for free, it is incumbent upon you to provide the source so that others can also access it for free;
\n\t
Provide information about the first publisher – please note the fact that the material was originally published by IntechOpen as an OA (Open Access) Work must be acknowledged.
\n
\n\n
Every single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
\n\n
In the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\n\n
IntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\n\n
All these rules apply to BOTH online and offline use.
\n\n
Parts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\n\n
All the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
\n\n
Policy last updated: 2016-06-09
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6675},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2460},{group:"region",caption:"Asia",value:4,count:12718},{group:"region",caption:"Australia and Oceania",value:5,count:1018},{group:"region",caption:"Europe",value:6,count:17721}],offset:12,limit:12,total:134178},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"12"},books:[{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",subtitle:null,isOpenForSubmission:!0,hash:"a58c7b02d07903004be70f744f2e1835",slug:null,bookSignature:"Prof. Mohamed Nageeb Rashed and Prof. Wafaa M. Abd El-Rahim",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",editedByType:null,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11457",title:"Forest Degradation Under Global Change",subtitle:null,isOpenForSubmission:!0,hash:"8df7150b01ae754024c65d1a62f190d9",slug:null,bookSignature:"Dr. Pavel Samec",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",editedByType:null,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11650",title:"Aquifers - New Insights",subtitle:null,isOpenForSubmission:!0,hash:"27c1a2a053cb1d83de903c5b969bc3a2",slug:null,bookSignature:"Dr. Abhay Soni and Dr. Prabhat Jain",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",editedByType:null,editors:[{id:"271093",title:"Dr.",name:"Abhay",surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11665",title:"Recent Advances in Wildlife Management",subtitle:null,isOpenForSubmission:!0,hash:"73da0df494a1a56ab9c4faf2ee811899",slug:null,bookSignature:"Dr. Farzana Khan Perveen",coverURL:"https://cdn.intechopen.com/books/images_new/11665.jpg",editedByType:null,editors:[{id:"75563",title:"Dr.",name:"Farzana Khan",surname:"Perveen",slug:"farzana-khan-perveen",fullName:"Farzana Khan Perveen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c8890038b86fb6e5af16ea3c22669ae9",slug:null,bookSignature:"Dr. Adnan Mustafa and Dr. Muhammad Naveed",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",editedByType:null,editors:[{id:"299110",title:"Dr.",name:"Adnan",surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11668",title:"Mercury Pollution",subtitle:null,isOpenForSubmission:!0,hash:"0bd111f57835089cad4a9741326dbab7",slug:null,bookSignature:"Dr. Ahmed Abdelhafez and Dr. Mohamed Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",editedByType:null,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12130",title:"Sustainable Built Environment",subtitle:null,isOpenForSubmission:!0,hash:"ed1dbae71b967e06efb049208f0c1068",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12130.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12131",title:"Climate Change and Fires",subtitle:null,isOpenForSubmission:!0,hash:"ea0858f07a3e87aaf9e5eaa75b4b44bd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12131.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12180",title:"Wetlands",subtitle:null,isOpenForSubmission:!0,hash:"8957c5c2baaed32223f911a6d4aa5a03",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12180.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12221",title:"Air Pollution",subtitle:null,isOpenForSubmission:!0,hash:"439a018ee0c4960560cb798601f2a372",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12221.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12222",title:"Advances and Challenges in Microplastics",subtitle:null,isOpenForSubmission:!0,hash:"a36734a551e0997d2255f6ce99eff818",slug:null,bookSignature:"Prof. El-Sayed Salama",coverURL:"https://cdn.intechopen.com/books/images_new/12222.jpg",editedByType:null,editors:[{id:"347657",title:"Prof.",name:"El-Sayed",surname:"Salama",slug:"el-sayed-salama",fullName:"El-Sayed Salama"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:22},{group:"topic",caption:"Computer and Information Science",value:9,count:23},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:63},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:15},{group:"topic",caption:"Materials Science",value:14,count:24},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:112},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:14},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4431},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"379",title:"Vitaminology",slug:"alimentology-vitaminology",parent:{id:"42",title:"Alimentology",slug:"alimentology"},numberOfBooks:12,numberOfSeries:0,numberOfAuthorsAndEditors:252,numberOfWosCitations:133,numberOfCrossrefCitations:140,numberOfDimensionsCitations:264,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"379",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",isOpenForSubmission:!1,hash:"8b43add5389ba85743e0a9491e4b9943",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",editedByType:"Edited by",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11021",title:"B-Complex Vitamins",subtitle:"Sources, Intakes and Novel Applications",isOpenForSubmission:!1,hash:"ad50bc292cda8d24f11aef2f5ef88f51",slug:"b-complex-vitamins-sources-intakes-and-novel-applications",bookSignature:"Jean Guy LeBlanc",coverURL:"https://cdn.intechopen.com/books/images_new/11021.jpg",editedByType:"Edited by",editors:[{id:"67023",title:"Dr.",name:"Jean Guy",middleName:null,surname:"LeBlanc",slug:"jean-guy-leblanc",fullName:"Jean Guy LeBlanc"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",isOpenForSubmission:!1,hash:"6c3ddcc13626110de289b57f2516ac8f",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",editedByType:"Edited by",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10631",title:"Vitamin D",subtitle:null,isOpenForSubmission:!1,hash:"34a58a10957f49842f0b13d78ccacb09",slug:"vitamin-d",bookSignature:"Öner Özdemir",coverURL:"https://cdn.intechopen.com/books/images_new/10631.jpg",editedByType:"Edited by",editors:[{id:"62921",title:"Dr.",name:"Öner",middleName:null,surname:"Özdemir",slug:"oner-ozdemir",fullName:"Öner Özdemir"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7038",title:"Vitamin D Deficiency",subtitle:null,isOpenForSubmission:!1,hash:"ba24f0913341357b0779ff9529c4bbfc",slug:"vitamin-d-deficiency",bookSignature:"Julia Fedotova",coverURL:"https://cdn.intechopen.com/books/images_new/7038.jpg",editedByType:"Edited by",editors:[{id:"269070",title:"Prof.",name:"Julia",middleName:null,surname:"Fedotova",slug:"julia-fedotova",fullName:"Julia Fedotova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8594",title:"Fads and Facts about Vitamin D",subtitle:null,isOpenForSubmission:!1,hash:"1731029867f0d79c633e3408fc03ebd2",slug:"fads-and-facts-about-vitamin-d",bookSignature:"Edward T. Zawada Jr.",coverURL:"https://cdn.intechopen.com/books/images_new/8594.jpg",editedByType:"Edited by",editors:[{id:"16344",title:"Dr.",name:"Edward T.",middleName:null,surname:"Zawada Jr.",slug:"edward-t.-zawada-jr.",fullName:"Edward T. Zawada Jr."}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,isOpenForSubmission:!1,hash:"dad04a658ab9e3d851d23705980a688b",slug:"vitamin-a",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",editedByType:"Edited by",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7033",title:"Vitamin C",subtitle:"an Update on Current Uses and Functions",isOpenForSubmission:!1,hash:"719a5742e3271393fe43864e13e996cd",slug:"vitamin-c-an-update-on-current-uses-and-functions",bookSignature:"Jean Guy LeBlanc",coverURL:"https://cdn.intechopen.com/books/images_new/7033.jpg",editedByType:"Edited by",editors:[{id:"67023",title:"Dr.",name:"Jean Guy",middleName:null,surname:"LeBlanc",slug:"jean-guy-leblanc",fullName:"Jean Guy LeBlanc"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7263",title:"Vitamin E in Health and Disease",subtitle:null,isOpenForSubmission:!1,hash:"6bd8e547b4f3ad7f1675a36b8dbde8f2",slug:"vitamin-e-in-health-and-disease",bookSignature:"Jose Antonio Morales-Gonzalez",coverURL:"https://cdn.intechopen.com/books/images_new/7263.jpg",editedByType:"Edited by",editors:[{id:"109774",title:"Dr.",name:"Jose Antonio",middleName:null,surname:"Morales-Gonzalez",slug:"jose-antonio-morales-gonzalez",fullName:"Jose Antonio Morales-Gonzalez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6709",title:"B Group Vitamins",subtitle:"Current Uses and Perspectives",isOpenForSubmission:!1,hash:"f34959a0fcc33a2c6fb3d03e9ec544bf",slug:"b-group-vitamins-current-uses-and-perspectives",bookSignature:"Jean Guy LeBlanc and Graciela Savoy de Giori",coverURL:"https://cdn.intechopen.com/books/images_new/6709.jpg",editedByType:"Edited by",editors:[{id:"67023",title:"Dr.",name:"Jean Guy",middleName:null,surname:"LeBlanc",slug:"jean-guy-leblanc",fullName:"Jean Guy LeBlanc"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5940",title:"Vitamin C",subtitle:null,isOpenForSubmission:!1,hash:"e23e79359167bb9d4a53edd78c7b5038",slug:"vitamin-c",bookSignature:"Amal H. Hamza",coverURL:"https://cdn.intechopen.com/books/images_new/5940.jpg",editedByType:"Edited by",editors:[{id:"188326",title:"Associate Prof.",name:"Amal",middleName:null,surname:"Hamza",slug:"amal-hamza",fullName:"Amal Hamza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5169",title:"Vitamin K2",subtitle:"Vital for Health and Wellbeing",isOpenForSubmission:!1,hash:"b2f9f024939ddc4f5da2a8afa3fcd9c9",slug:"vitamin-k2-vital-for-health-and-wellbeing",bookSignature:"Jan Oxholm Gordeladze",coverURL:"https://cdn.intechopen.com/books/images_new/5169.jpg",editedByType:"Edited by",editors:[{id:"36345",title:"Prof.",name:"Jan",middleName:"Oxholm",surname:"Gordeladze",slug:"jan-gordeladze",fullName:"Jan Gordeladze"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:12,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"56013",doi:"10.5772/intechopen.69660",title:"Vitamin C: An Antioxidant Agent",slug:"vitamin-c-an-antioxidant-agent",totalDownloads:7788,totalCrossrefCites:26,totalDimensionsCites:57,abstract:"Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby neutralize, reactive oxygen species. It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"56440",doi:"10.5772/intechopen.70162",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6400,totalCrossrefCites:14,totalDimensionsCites:26,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"50921",doi:"10.5772/63712",title:"Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet",slug:"menaquinones-bacteria-and-foods-vitamin-k2-in-the-diet",totalDownloads:3301,totalCrossrefCites:10,totalDimensionsCites:21,abstract:"Vitamin K2 is a collection of isoprenologues that mostly originate from bacterial synthesis, also called menaquinones (MKs). Multiple bacterial species used as starter cultures for food fermentation are known to synthesize MK. Therefore, fermented food is the best source of vitamin K2. In the Western diet, dairy products are one of the best known and most commonly consumed group of fermented products.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Barbara Walther and Magali Chollet",authors:[{id:"184784",title:"Dr.",name:"Barbara",middleName:null,surname:"Walther",slug:"barbara-walther",fullName:"Barbara Walther"},{id:"188194",title:"Mrs.",name:"Magali",middleName:null,surname:"Chollet",slug:"magali-chollet",fullName:"Magali Chollet"}]},{id:"66098",doi:"10.5772/intechopen.84445",title:"Golden Rice: To Combat Vitamin A Deficiency for Public Health",slug:"golden-rice-to-combat-vitamin-a-deficiency-for-public-health",totalDownloads:3345,totalCrossrefCites:12,totalDimensionsCites:17,abstract:"Vitamin A deficiency (VAD) has been recognised as a significant public health problem continuously for more than 30 years, despite current interventions. The problem is particularly severe in populations where rice is the staple food and diversity of diet is limited, as white rice contains no micronutrients. Golden Rice is a public-sector product designed as an additional intervention for VAD. There will be no charge for the nutritional trait, which has been donated by its inventors for use in public-sector rice varieties to assist the resource poor, and no limitations on what small farmers can do with the crop—saving and replanting seed, selling seed and selling grain are all possible. Because Golden Rice had to be created by introducing two new genes—one from maize and the other from a very commonly ingested soil bacterium—it has taken a long time to get from the laboratory to the field. Now it has been formally registered as safe as food, feed, or in processed form by four industrialised counties, and applications are pending in developing countries. The data are summarised here, and criticisms addressed, for a public health professional audience: is it needed, will it work, is it safe and is it economic? Adoption of Golden Rice, the next step after in-country registration, requires strategic and tactical cooperation across professions, non-governmental organisations (NGOs) and government departments often not used to working together. Public health professionals need to play a prominent role.",book:{id:"7978",slug:"vitamin-a",title:"Vitamin A",fullTitle:"Vitamin A"},signatures:"Adrian Dubock",authors:[{id:"273220",title:"Ph.D.",name:"Adrian",middleName:null,surname:"Dubock",slug:"adrian-dubock",fullName:"Adrian Dubock"}]},{id:"62836",doi:"10.5772/intechopen.79350",title:"The Role of Thiamine in Plants and Current Perspectives in Crop Improvement",slug:"the-role-of-thiamine-in-plants-and-current-perspectives-in-crop-improvement",totalDownloads:1557,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Current research is focusing on selecting potential genes that can alleviate stress and produce disease-tolerant crop variety. The novel paradigm is to investigate the potential of thiamine as a crop protection molecule in plants. Thiamine or vitamin B1 is important for primary metabolism for all living organisms. The active form, thiamine pyrophosphate (TPP), is a cofactor for the enzymes involved in the synthesis of amino acids, tricarboxylic acid cycle and pentose phosphate pathway. Recently, thiamine is shown to have a role in the processes underlying protection of plants against biotic and abiotic stresses. The aim of this chapter is to review the role of thiamine in plant growth and disease protection and also to highlight that TPP and its intermediates are involved in management of stress. The perspectives on its potential for manipulating the biosynthesis pathway in crop improvement will also be discussed.",book:{id:"6709",slug:"b-group-vitamins-current-uses-and-perspectives",title:"B Group Vitamins",fullTitle:"B Group Vitamins - Current Uses and Perspectives"},signatures:"Atiqah Subki, Aisamuddin Ardi Zainal Abidin and Zetty Norhana\nBalia Yusof",authors:[{id:"240031",title:"Dr.",name:"Zetty-Norhana Balia",middleName:null,surname:"Yusof",slug:"zetty-norhana-balia-yusof",fullName:"Zetty-Norhana Balia Yusof"},{id:"261167",title:"Mr.",name:"Aisamuddin Ardi",middleName:null,surname:"Zainal Abidin",slug:"aisamuddin-ardi-zainal-abidin",fullName:"Aisamuddin Ardi Zainal Abidin"},{id:"261169",title:"Ms.",name:"Atiqah",middleName:null,surname:"Subki",slug:"atiqah-subki",fullName:"Atiqah Subki"}]}],mostDownloadedChaptersLast30Days:[{id:"56440",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6391,totalCrossrefCites:14,totalDimensionsCites:25,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"56013",title:"Vitamin C: An Antioxidant Agent",slug:"vitamin-c-an-antioxidant-agent",totalDownloads:7779,totalCrossrefCites:26,totalDimensionsCites:55,abstract:"Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby neutralize, reactive oxygen species. It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"69402",title:"Vitamin D Deficiency and Diabetes Mellitus",slug:"vitamin-d-deficiency-and-diabetes-mellitus",totalDownloads:1578,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Vitamin D (VD) is a molecule that can be synthesized directly in the humans’ body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D–1,25(OH)2D. 1,25(OH)2D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells’ functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.",book:{id:"7038",slug:"vitamin-d-deficiency",title:"Vitamin D Deficiency",fullTitle:"Vitamin D Deficiency"},signatures:"Ihor Shymanskyi, Olha Lisakovska, Anna Mazanova and Mykola Veliky",authors:null},{id:"76108",title:"Vitamin D Metabolism",slug:"vitamin-d-metabolism",totalDownloads:461,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Vitamin D plays an important role in bone metabolism. Vitamin D is a group of biologically inactive, fat-soluble prohormones that exist in two major forms: ergocalciferol (vitamin D2) produced by plants in response to ultraviolet irradiation and cholecalciferol (vitamin D3) derived from animal tissues or 7-dehydrocholesterol in human skin by the action of ultraviolet rays present in sunlight. Vitamin D, which is biologically inactive, needs two-step hydroxylation for activation. All of these steps are of crucial for Vitamin D to show its effect properly. In this section, we will present vitamin D synthesis and its action steps in detail.",book:{id:"10631",slug:"vitamin-d",title:"Vitamin D",fullTitle:"Vitamin D"},signatures:"Sezer Acar and Behzat Özkan",authors:[{id:"29878",title:"Dr.",name:"Behzat",middleName:null,surname:"Özkan",slug:"behzat-ozkan",fullName:"Behzat Özkan"},{id:"348287",title:"Dr.",name:"Sezer",middleName:null,surname:"Acar",slug:"sezer-acar",fullName:"Sezer Acar"}]},{id:"50754",title:"Medicinal Chemistry of Vitamin K Derivatives and Metabolites",slug:"medicinal-chemistry-of-vitamin-k-derivatives-and-metabolites",totalDownloads:1904,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Vitamin K acts as a cofactor for γ‐glutamyl carboxylase. Recently, various biological activities of vitamin K have been reported. Anti‐proliferative activities of vitamin K, especially in vitamin K3, are well known. In addition, various physiological and pharmacological functions of vitamin K2, such as transcription modulators as nuclear steroid and xenobiotic receptor (SXR) ligands and anti‐inflammatory effects, have been revealed in the past decade. Characterization of vitamin K metabolites is also important for clinical application of vitamin K and its derivatives. In this chapter, recent progress on the medicinal chemistry of vitamin K derivatives and metabolites is discussed.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Shinya Fujii and Hiroyuki Kagechika",authors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"},{id:"180529",title:"Dr.",name:"Shinya",middleName:null,surname:"Fujii",slug:"shinya-fujii",fullName:"Shinya Fujii"}]}],onlineFirstChaptersFilter:{topicId:"379",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"
\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
",coverUrl:"https://cdn.intechopen.com/series/covers/25.jpg",latestPublicationDate:"June 28th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"197485",title:"Dr.",name:"J. Kevin",middleName:null,surname:"Summers",slug:"j.-kevin-summers",fullName:"J. Kevin Summers",profilePictureURL:"https://mts.intechopen.com/storage/users/197485/images/system/197485.jpg",biography:"J. Kevin Summers is a Senior Research Ecologist at the Environmental Protection Agency’s (EPA) Gulf Ecosystem Measurement and Modeling Division. He is currently working with colleagues in the Sustainable and Healthy Communities Program to develop an index of community resilience to natural hazards, an index of human well-being that can be linked to changes in the ecosystem, social and economic services, and a community sustainability tool for communities with populations under 40,000. He leads research efforts for indicator and indices development. Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. Dr. Summers holds a BA in Zoology and Psychology, an MA in Ecology, and Ph.D. in Systems Ecology/Biology.",institutionString:null,institution:{name:"Environmental Protection Agency",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:12,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",slug:"meng-chuan-ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",slug:"olga-anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",slug:"elke-jurandy-bran-nogueira-cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"147289",title:"Prof.",name:"Francisco",middleName:null,surname:"Guevara-Hernández",slug:"francisco-guevara-hernandez",fullName:"Francisco Guevara-Hernández",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRCgVQAW/Profile_Picture_2022-06-27T11:25:21.png",institutionString:null,institution:{name:"Autonomous University of Chiapas",institutionURL:null,country:{name:"Mexico"}}},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",slug:"sandra-ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},{id:"40",title:"Ecosystems and Biodiversity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",editor:{id:"209149",title:"Prof.",name:"Salustiano",middleName:null,surname:"Mato",slug:"salustiano-mato",fullName:"Salustiano Mato",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLREQA4/Profile_Picture_2022-03-31T10:23:50.png",biography:"Salustiano Mato de la Iglesia (Santiago de Compostela, 1960) is a doctor in biology from the University of Santiago and a Professor of zoology at the Department of Ecology and Animal Biology at the University of Vigo. He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. The result of this line of work are three invention patents and various scientific and technical publications in prestigious international journals.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",slug:"josefina-garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",biography:"Josefina Garrido González (Paradela de Abeleda, Ourense 1959), is a doctor in biology from the University of León and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. She has focused her research activity on the taxonomy, fauna and ecology of aquatic beetles, in addition to other lines of research such as the conservation of biodiversity in freshwater ecosystems; conservation of protected areas (Red Natura 2000) and assessment of the effectiveness of wetlands as priority areas for the conservation of aquatic invertebrates; studies of water quality in freshwater ecosystems through biological indicators and physicochemical parameters; surveillance and research of vector arthropods and invasive alien species.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",slug:"francisco-ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",biography:"Fran Ramil Blanco (Porto de Espasante, A Coruña, 1960), is a doctor in biology from the University of Santiago de Compostela and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. His research activity is linked to the taxonomy, fauna and ecology of marine benthic invertebrates and especially the Cnidarian group. Since 2004, he has been part of the EcoAfrik project, aimed at the study, protection and conservation of biodiversity and benthic habitats in West Africa. He also participated in the study of vulnerable marine ecosystems associated with seamounts in the South Atlantic and is involved in training young African researchers in the field of marine research.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorialBoard:[{id:"220987",title:"Dr.",name:"António",middleName:"Onofre",surname:"Soares",slug:"antonio-soares",fullName:"António Soares",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNtzQAG/Profile_Picture_1644499672340",institutionString:null,institution:{name:"University of the Azores",institutionURL:null,country:{name:"Portugal"}}}]},{id:"41",title:"Water Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",biography:"Prof. Dr. Yizi Shang is a pioneering researcher in hydrology and water resources who has devoted his research career to promoting the conservation and protection of water resources for sustainable development. He is presently associate editor of Water International (official journal of the International Water Resources Association). He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"216491",title:"Dr.",name:"Charalampos",middleName:null,surname:"Skoulikaris",slug:"charalampos-skoulikaris",fullName:"Charalampos Skoulikaris",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRMsbQAG/Profile_Picture_2022-04-21T09:31:55.jpg",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"300124",title:"Prof.",name:"Thomas",middleName:null,surname:"Shahady",slug:"thomas-shahady",fullName:"Thomas Shahady",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002kuIgmQAE/Profile_Picture_2022-03-18T07:32:10.jpg",institutionString:null,institution:{name:"Lynchburg College",institutionURL:null,country:{name:"United States of America"}}}]}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. Agogbua, Eberechi R. Keyagha and Itorobong I. Nkanga",slug:"carotenoids-in-cassava-manihot-esculenta-crantz",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. Heshmati",slug:"comparative-senescence-and-lifespan",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hassan M.",surname:"Heshmati"}],book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}]},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:8,paginationItems:[{id:"11662",title:"Limnology - The Importance of Monitoring and Correlations of Lentic and Lotic Waters",coverURL:"https://cdn.intechopen.com/books/images_new/11662.jpg",hash:"f1043cf6b1daae7a7b527e1d162ca4a8",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"315689",title:"Dr.",name:"Carmine",surname:"Massarelli",slug:"carmine-massarelli",fullName:"Carmine Massarelli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11665",title:"Recent Advances in Wildlife Management",coverURL:"https://cdn.intechopen.com/books/images_new/11665.jpg",hash:"73da0df494a1a56ab9c4faf2ee811899",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 25th 2022",isOpenForSubmission:!0,editors:[{id:"75563",title:"Dr.",name:"Farzana Khan",surname:"Perveen",slug:"farzana-khan-perveen",fullName:"Farzana Khan Perveen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",hash:"c8890038b86fb6e5af16ea3c22669ae9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 9th 2022",isOpenForSubmission:!0,editors:[{id:"299110",title:"Dr.",name:"Adnan",surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",hash:"727e7eb3d4ba529ec5eb4f150e078523",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 22nd 2022",isOpenForSubmission:!0,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12222",title:"Advances and Challenges in Microplastics",coverURL:"https://cdn.intechopen.com/books/images_new/12222.jpg",hash:"a36734a551e0997d2255f6ce99eff818",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 1st 2022",isOpenForSubmission:!0,editors:[{id:"347657",title:"Prof.",name:"El-Sayed",surname:"Salama",slug:"el-sayed-salama",fullName:"El-Sayed Salama"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11650",title:"Aquifers - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",hash:"27c1a2a053cb1d83de903c5b969bc3a2",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 12th 2022",isOpenForSubmission:!0,editors:[{id:"271093",title:"Dr.",name:"Abhay",surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12223",title:"Sustainable Management of Natural Resources",coverURL:"https://cdn.intechopen.com/books/images_new/12223.jpg",hash:"1881a08bbd8f5dc1102c5cb7c635bc35",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 19th 2022",isOpenForSubmission:!0,editors:[{id:"144417",title:"Dr.",name:"Mohd Nazip",surname:"Suratman",slug:"mohd-nazip-suratman",fullName:"Mohd Nazip Suratman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11668",title:"Mercury Pollution",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",hash:"0bd111f57835089cad4a9741326dbab7",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 22nd 2022",isOpenForSubmission:!0,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}},{id:"82367",title:"Spatial Variation and Factors Associated with Unsuppressed HIV Viral Load among Women in an HIV Hyperendemic Area of KwaZulu-Natal, South Africa",doi:"10.5772/intechopen.105547",signatures:"Adenike O. Soogun, Ayesha B.M. Kharsany, Temesgen Zewotir and Delia North",slug:"spatial-variation-and-factors-associated-with-unsuppressed-hiv-viral-load-among-women-in-an-hiv-hype",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"HIV-AIDS - Updates, Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82193",title:"Enterococcal Infections: Recent Nomenclature and emerging trends",doi:"10.5772/intechopen.104792",signatures:"Kavita Raja",slug:"enterococcal-infections-recent-nomenclature-and-emerging-trends",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82207",title:"Management Strategies in Perinatal HIV",doi:"10.5772/intechopen.105451",signatures:"Kayla Aleshire and Rima Bazzi",slug:"management-strategies-in-perinatal-hiv",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"HIV-AIDS - Updates, Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82013",title:"Streamlining Laboratory Tests for HIV Detection",doi:"10.5772/intechopen.105096",signatures:"Ramakrishna Prakash and Mysore Krishnamurthy Yashaswini",slug:"streamlining-laboratory-tests-for-hiv-detection",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"HIV-AIDS - Updates, Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"81972",title:"The Submicroscopic Plasmodium falciparum Malaria in Sub-Saharan Africa; Current Understanding of the Host Immune System and New Perspectives",doi:"10.5772/intechopen.105086",signatures:"Kwame Kumi Asare",slug:"the-submicroscopic-plasmodium-falciparum-malaria-in-sub-saharan-africa-current-understanding-of-the-",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81821",title:"Pneumococcal Carriage in Jordanian Children and the Importance of Vaccination",doi:"10.5772/intechopen.104999",signatures:"Adnan Al-Lahham",slug:"pneumococcal-carriage-in-jordanian-children-and-the-importance-of-vaccination",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"81813",title:"Schistosomiasis: Discovery of New Molecules for Disease Treatment and Vaccine Development",doi:"10.5772/intechopen.104738",signatures:"Andressa Barban do Patrocinio",slug:"schistosomiasis-discovery-of-new-molecules-for-disease-treatment-and-vaccine-development",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:22,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:64,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:2,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:3,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:4,group:"subseries"}],publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10843",title:"Persistent Organic Pollutants (POPs)",subtitle:"Monitoring, Impact and Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10843.jpg",slug:"persistent-organic-pollutants-pops-monitoring-impact-and-treatment",publishedDate:"April 13th 2022",editedByType:"Edited by",bookSignature:"Mohamed Nageeb Rashed",hash:"f5b1589f0a990b6114fef2dadc735dd9",volumeInSeries:1,fullTitle:"Persistent Organic Pollutants (POPs) - Monitoring, Impact and Treatment",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Pollution",value:38,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"302145",title:"Dr.",name:"Felix",middleName:null,surname:"Bongomin",slug:"felix-bongomin",fullName:"Felix Bongomin",profilePictureURL:"https://mts.intechopen.com/storage/users/302145/images/system/302145.jpg",institutionString:null,institution:{name:"Gulu University",institutionURL:null,country:{name:"Uganda"}}},{id:"45803",title:"Ph.D.",name:"Payam",middleName:null,surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi",profilePictureURL:"https://mts.intechopen.com/storage/users/45803/images/system/45803.jpg",institutionString:"Islamic Azad University, Tehran",institution:{name:"Islamic Azad University, Tehran",institutionURL:null,country:{name:"Iran"}}}]},onlineFirstChapters:{paginationCount:14,paginationItems:[{id:"82457",title:"Canine Hearing Management",doi:"10.5772/intechopen.105515",signatures:"Peter M. Skip Scheifele, Devan Marshall, Stephen Lee, Paul Reid, Thomas McCreery and David Byrne",slug:"canine-hearing-management",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82285",title:"Parvovirus Vectors: The Future of Gene Therapy",doi:"10.5772/intechopen.105085",signatures:"Megha Gupta",slug:"parvovirus-vectors-the-future-of-gene-therapy",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82170",title:"Equine Stress: Neuroendocrine Physiology and Pathophysiology",doi:"10.5772/intechopen.105045",signatures:"Milomir Kovac, Tatiana Vladimirovna Ippolitova, Sergey Pozyabin, Ruslan Aliev, Viktoria Lobanova, Nevena Drakul and Catrin S. Rutland",slug:"equine-stress-neuroendocrine-physiology-and-pathophysiology",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:19,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:38,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:153,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",doi:"10.5772/intechopen.100051",signatures:"Chan I-Ping and Hsueh Tung",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:183,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",doi:"10.5772/intechopen.99067",signatures:"Christophe Casteleyn and Jaco Bakker",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:355,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"77999",title:"Bronchus-Associated Lymphoid Tissue (BALT) Histology and Its Role in Various Pathologies",doi:"10.5772/intechopen.99366",signatures:"Tuba Parlak Ak",slug:"bronchus-associated-lymphoid-tissue-balt-histology-and-its-role-in-various-pathologies",totalDownloads:212,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78242",title:"Genomic Instability and Cyto-Genotoxic Damage in Animal Species",doi:"10.5772/intechopen.99685",signatures:"María Evarista Arellano-García, Olivia Torres-Bugarín, Maritza Roxana García-García, Daniel García-Flores, Yanis Toledano-Magaña, Cinthya Sofia Sanabria-Mora, Sandra Castro-Gamboa and Juan Carlos García-Ramos",slug:"genomic-instability-and-cyto-genotoxic-damage-in-animal-species",totalDownloads:150,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78503",title:"Biomechanics of the Canine Elbow Joint",doi:"10.5772/intechopen.99569",signatures:"Thomas Rohwedder",slug:"biomechanics-of-the-canine-elbow-joint",totalDownloads:180,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78018",title:"Application of Noble Metals in the Advances in Animal Disease Diagnostics",doi:"10.5772/intechopen.99162",signatures:"Gabriel Alexis S.P. Tubalinal, Leonard Paulo G. Lucero, Jim Andreus V. Mangahas, Marvin A. Villanueva and Claro N. Mingala",slug:"application-of-noble-metals-in-the-advances-in-animal-disease-diagnostics",totalDownloads:111,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"77455",title:"Marek’s Disease Is a Threat for Large Scale Poultry Production",doi:"10.5772/intechopen.98939",signatures:"Wojciech Kozdruń, Jowita Samanta Niczyporuk and Natalia Styś-Fijoł",slug:"marek-s-disease-is-a-threat-for-large-scale-poultry-production",totalDownloads:261,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"74655",title:"Taxon-Specific Pair Bonding in Gibbons (Hylobatidae)",doi:"10.5772/intechopen.95270",signatures:"Thomas Geissmann, Simone Rosenkranz-Weck, Judith J.G.M. Van Der Loo and Mathias Orgeldinger",slug:"taxon-specific-pair-bonding-in-gibbons-hylobatidae",totalDownloads:398,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}}]},publishedBooks:{paginationCount:7,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Dr.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:null,institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[{type:"book",id:"11672",title:"Chemokines Updates",subtitle:null,isOpenForSubmission:!0,hash:"c00855833476a514d37abf7c846e16e9",slug:null,bookSignature:"Prof. Murat Şentürk",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",editedByType:null,submissionDeadline:"May 6th 2022",editors:[{id:"14794",title:"Prof.",name:"Murat",middleName:null,surname:"Şentürk",slug:"murat-senturk",fullName:"Murat Şentürk",profilePictureURL:"https://mts.intechopen.com/storage/users/14794/images/system/14794.jpeg",biography:"Dr. Murat Şentürk obtained a baccalaureate degree in Chemistry in 2002, a master’s degree in Biochemistry in 2006, and a doctorate degree in Biochemistry in 2009 from Atatürk University, Turkey. Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. Dr. Şentürk serves as the editorial board member of several international journals.",institutionString:"Ağrı İbrahim Çeçen University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ağrı İbrahim Çeçen University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:{title:"Infectious Diseases",id:"6"},selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:318,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/70703",hash:"",query:{},params:{id:"70703"},fullPath:"/chapters/70703",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()