Difference between IaaS and PaaS.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1421",leadTitle:null,fullTitle:"Ion Implantation",title:"Ion Implantation",subtitle:null,reviewType:"peer-reviewed",abstract:"Ion implantation presents a continuously evolving technology. While the benefits of ion implantation are well recognized for many commercial endeavors, there have been recent developments in this field. Improvements in equipment, understanding of beam-solid interactions, applications to new materials, improved characterization techniques, and more recent developments to use implantation for nanostructure formation point to new directions for ion implantation and are presented in this book.",isbn:null,printIsbn:"978-953-51-0634-0",pdfIsbn:"978-953-51-4292-8",doi:"10.5772/1881",price:139,priceEur:155,priceUsd:179,slug:"ion-implantation",numberOfPages:450,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"b26dd84d6e82655fa8629dd119ad491e",bookSignature:"Mark Goorsky",publishedDate:"May 30th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1421.jpg",numberOfDownloads:41600,numberOfWosCitations:107,numberOfCrossrefCitations:23,numberOfCrossrefCitationsByBook:20,numberOfDimensionsCitations:55,numberOfDimensionsCitationsByBook:31,hasAltmetrics:0,numberOfTotalCitations:185,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 12th 2011",dateEndSecondStepPublish:"May 10th 2011",dateEndThirdStepPublish:"September 14th 2011",dateEndFourthStepPublish:"October 14th 2011",dateEndFifthStepPublish:"February 13th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"20365",title:"Prof.",name:"Mark",middleName:null,surname:"Goorsky",slug:"mark-goorsky",fullName:"Mark Goorsky",profilePictureURL:"https://mts.intechopen.com/storage/users/20365/images/3482_n.jpg",biography:"Mark Goorsky is a Professor of Materials Science and Engineering at UCLA and was chair of the department from 2004-2009. 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Many industries are already gaining from digitalisation journey and Internet of Things (IoT), and industrial manufacturing is leading the way [1, 2, 3]. The IIoT is considered to be a modern manufacturing concept under Industry 4.0 and has been evolving rapidly based on the industrial requirement. A typical IIoT platform should consist of cutting-edge information technology (IT) infrastructure for data acquisition and sharing [4]. The features of an intelligent manufacturing includes real-time data collection and sharing among various manufacturing resources such as machines, subsystems, operators, and materials [5].
\nThe ability to “sensorize” all and extract data to offer insights and forecasts is a huge benefit for manufacturing [6]. The Internet of Things and data remain inherently linked together. If a system goes down, for example, connected sensors can automatically localise the issue. This process is time-intensive when humans do it manually. Apart from sensorization, ubiquitous connectivity is the crucial pillar of IoT that assures to deliver the value by connecting numerous devices/assets that generate useful data. Acquiring accurate and reliable data from machines and their components is the first step in developing an IIoT architecture. Sensors might directly measure the data, which can also be obtained from controllers. Data might also be acquired from enterprise manufacturing applications such as enterprise resource planner (ERP), manufacturing execution system (MES), supply chain management system (SCMS), etc. [7]. As far as data, two important factors have to be considered. Firstly, selecting proper sensors (type and specification) for the specific objective is critical. Secondly, a seamless and tether-free method to manage the acquisition and transfer data considering various data types to the central server is required.
\nThe data generated from IoT devices turn out to be of value only if it gets subjected to analysis, which brings data-driven analytics into the architecture. Data analytics (DA) is defined as a process, which is used to examine big and small data sets with different data properties to extract meaningful conclusions and actionable insights. These conclusions of data analysis are usually in the form of trends, patterns, and statistics that aid in effective decision-making processes. Data analysis requires support such as hardware resources such as GPU and servers for computing. The frequency of using the results of analytics may vary from real-time problems such as anomaly detection and tool wear [8, 9] to long intervals, such as predicting remaining useful life [10]. Depending on the requirement, analytics can be performed locally, i.e. edge or remotely, i.e. the cloud.
\nAccording to the aforementioned current problem statement, the IIoT-based cyber-physical system for manufacturing can fill this gap. One typical architecture of the IIoT-based cyber-physical system for manufacturing is shown in \nFigure 1\n. The first IoT layer captures data from IoT devices such as geographic coordinates, RFIDs, sensor signals, or other unstructured data. With the help of advanced computer networks, such as cyber (or software), resources and tools can be integrated with the manufacturing equipment. Connectivity is what enables the three pillar devices, data, and analytics to work. Devices must be interconnected to transfer data. Data cannot be sent or received without reliable high-bandwidth connectivity that supports real-time data flow from the many devices living on a network. Without connectivity, there would be no data to analyse and no analytics available to optimise systems and create efficiencies. IoT deployments would lack scalability. A standardised communication protocol is always required for data exchange. Many IIoT protocols can be used for networking machines, such as the Message Queuing Telemetry Transport (MQTT) protocol and the Constrained Application Protocol (CoAP). However, connectivity also exposes industrial devices to security attacks which not only disrupt entire systems but can also pose safety risks. An IIoT platform must provide security to minimise risks and keep operations protected from physical breaches and cyberattacks, by monitoring the behaviour of all data sources and alerting operators when anomalies are detected in the manufacturing environment. Securing end-to-end IIoT systems is critical in order to avoid unwanted financial and safety consequences.
\nArchitecture of IIoT-based cyber-physical system for manufacturing [
The data are then stored and managed in the edge layer by IIoT platform. Like said before, it is the processing of the data acquired and stored that makes the factory realise the importance of digitalization. Data processing ranges from simple visualisation in the dashboard screen to complex cutting-edge data-driven algorithm output. High-end server or industrial PCs are generally used in this layer. Because of the cloud’s ability to house large amounts of data, they are a key pillar in IIoT architecture. Today, the potential of using cloud technologies for advanced manufacturing is very high. Cloud computing can be viewed as a model for enabling ubiquitous, convenient, on-demand network access to a shared pool of configurable computing resources including networks, storage, services, and servers. Cloud computing, as well as IoT, works towards increasing the efficiency of everyday tasks, and both have a complementary relationship [12]. On the one hand, IoT generates lots of data, while on the other hand, cloud computing paves the way for this data to travel [13]. Many cloud providers take advantage of this to provide a pay-as-you-use model where customers pay for the specific resources used.
\nIn today’s factories, most of machines/systems are not connected (brownfield) and thus cannot provide data or visibility. Multinetwork environments that include ageing machines of different types and software do not speak on common connectivity language. These two pose significant challenges for many IIoT solutions and hinder the implementation of data analytics. A thorough assessment, planning, scoping, and later execution are required for implementing and performing analytics for such machines to be a part of IIoT architecture, which will be demonstrated in this research work with two use case studies.
\nThe paper is organised as follows. A brief introduction to IIoT architecture is described in Section 1, followed by a brief overview on online quality measurement for manufacturing industries in Section 2. The experimental setup and IIoT architectural design for data analytics are presented in Sections 3 and 4. The results are described in Section 5, followed by conclusions in Section 6.
\nIn recent years, the development and optimization of advanced manufacturing processes have been continuously pushed to fulfil the higher demand for performance specification of the components produced. Due to a need for more consistent products quality, product variability and product complexity, there is an increase in the manufacturing cycle and product quality measurement time. The reduction of process quality measurement requires decision making by Artificial Intelligence (AI) algorithms for which a data transfer framework for connecting between sensors, robots and devices is required. In other words, the human intervention in manufacturing line will be decreased with the development of connected intelligent manufacturing floors allowing them to concentrate more over the processes optimization, newer product designs and even maintenance. By applying an intelligent architecture to take more control over the manufacturing processes, human inconsistency and measurement time can be reduced and at the same time production capacity can be increased. These architectures will also reduce the scrap materials and enable a cleaner environment. In this paper, two case studies of the evolution of manufacturing processes from the conventional manufacturing line to smart IoT- enabled manufacturing line is presented. The processes used in our case study are deburring and belt grinding.
\nAt present, the manufacturing industries, especially aerospace, are equipped with the industrial robots to perform manufacturing processes such as deburring and belt grinding for surface finishing. However, the output quality monitoring of surface finishing processes such as deburring and belt grinding is accomplished through conventional manual measurement. In high-volume productions, a manual measurement can lead to inconsistency from operator to operator and result in variations in product quality measurement such as thickness and surface roughness. \nFigure 2\n describes the deburring process cycle which involves conventional output quality measurement. As shown in \nFigure 2\n, which starts from the work coupon, the cycle only pauses at output quality measurement once the deburring or belt grinding process is executed. During the pause, the robot controller retracts the industrial robot to its home position. After which, an operator starts the measurement process. After the measurement is done, the cycle continues if the surface finish quality measured or required material removal is not achieved.
\nDeburring/belt grinding cycle in manufacturing.
In cloud computing, there are three categories of services to select from, namely, the Infrastructures a Service (IaaS), Platform as a Service (PaaS), and Software as a Service (SaaS). The sequence of these three in terms of development foundation can be described in \nFigure 3\n. PaaS is one layer above IaaS as platform is built on infrastructure and SaaS is one layer above PaaS as software is built on platform. The IaaS provides infrastructure consisting of computer resources and servers with network connectivity and cloud capability. Users have direct access to their servers and storage usually via application programming interface (API). The PaaS is built on a physical server infrastructure and provides a platform where users can build their software on. Meanwhile, SaaS provides ready-to-use software for users that can be accessed anywhere remotely as long as there is Internet connection. The SaaS, for example, are Google Apps, Microsoft Office 365, and Adobe Creative Cloud. Before proceeding further, the category of service has to be selected according to the requirement needed.
\nCloud services hierarchy.
In building the Internet of Things (IoT) application, Software as a Service is not a relevant choice to select, unless if there is third-party software found to be useful for the application required. Thus, the selection is between IaaS and PaaS. \nTable 1\n lists the differences between IaaS and PaaS in the context of manufacturing application.
\nCriteria | \nIaaS | \nPaaS | \n
---|---|---|
Developer main focus | \nStorage, networking, computing | \nBuilding application | \n
Platform flexibility to build software | \nFlexible as developer builds the software on a platform that is on a common infrastructure | \nNon-flexible as developer builds the software on a platform specific to the provider | \n
Learning curve | \nHigher learning curve as developer has to build both the platform and the software | \nLower learning curve as developer only has to focus on the software | \n
Scalability | \nAllow more flexibility | \nHas certain limit of scalability | \n
Intercommunication between software | \nAllow software of different platforms to communicate easily on the same infrastructures | \nSoftware of different platforms must communicate to each other from different infrastructures | \n
Difference between IaaS and PaaS.
After considering these differences, a conclusion can be drawn. Over the consideration of long-term commitment, IaaS would be suitable for the scalability to integrate different process-specific applications into one main application. However, the scale of this application is an enterprise-level of application. A research work explains the study of IaaS architecture in more detail which can be used a useful reference for the IaaS level of implementation [14]. Meanwhile, for project level, PaaS is most suitable to build the application on. It is because in PaaS, there is no need to consider infrastructure development. Instead, the focus can be directed towards application development.
\nIn addition to this, what cloud services are available in the market currently? In 2009 a performance comparison of several popular cloud services platform has been done [15]. The selection of cloud services should be adjusted to the time of implementation as cloud services features are always updated and have different advantages for different cloud services provider. The implementation of algorithm conversion to the cloud services provider is much easier to be done now as research platforms such as Python and LabVIEW are currently available. In addition to this difference, it is important to understand the architectural difference between the categories as explained in \nFigure 4\n. Hence, as PaaS is concerned, the development required to bring deburring into Industry 4.0 is on the applications and data.
\nArchitecture difference in cloud services.
The data flow of deburring and belt grinding process that includes the cloud services can be explained in \nFigure 5\n. In \nFigure 5\n, Storage Cloud Service (SCS) is the storage service to store the sensor data and the result in the cloud. Meanwhile, the computing cloud service (CCS) is the computing capacity to process the data. Thus, the machine learning is adapted to the cloud through CCS. This architecture provides API output for display or other applications when required. In addition, the data in SCS is also tapped into offline server or display when required.
\nDeburring and belt grinding data flow conversion from offline to online platform.
The difference in implementation between offline and online data analysis through the same machine learning model is described in \nTable 2\n, assuming the use of cloud services by third party.
\nDifferences | \nOffline data analysis | \nOnline data analysis | \n
---|---|---|
Memory storage and compute capacity | \nMachine learning performance limited by the built-in storage capacity and memory capacity in the controller | \nMachine learning performance limited only by the storage and compute quota purchased under the predefined budget | \n
Scalability | \nHardware and software scale-up requirement is time-consuming | \nOnly software scale-up requirement is time-consuming | \n
Data resource usage and compatibility | \nLocal data analysis using predefined development environment (e.g. LabVIEW) | \nCloud data analysis using more development environment options (e.g. TensorFlow, Kaffe2, Keras) | \n
Implementation difference between offline and online data analysis.
The robot-assisted manufacturing processes are gaining popularity in industries that move towards automation. Integration of the processes on the robot helps in easing the axis of motion and also ensures that the force applied and repeatability is maintained [16, 17]. Abrasive belt grinding and deburring processes are typically combined with an industrial robot in the manufacturing industry for achieving the desired surface finish and tolerance. In this paper, we will be demonstrating how these two brownfield manufacturing systems can be IoT enabled, and analytics can be performed at two different levels, i.e. cloud and edge. The process data from deburring will be used for edge analytics, and data from belt grinding will be used to perform machine vision analytics at the cloud.
\nThe fundamental of Industry 4.0 is the data communication. In deburring, the main data communication path happens between (1) the sensors to the DAQ (National instrument – Compact RIO) controller, (2) the DAQ controller to the robot controller, (3) robot controller to the ABB robot, and (4) DAQ controller to the server and cloud. The data communication is done through digital and analog input/output with the maximum analog transfer rate at 4 MS/s per module four 16-bit (64 kb) analog input. This translates to maximum of 256 Mb/s data transfer rate per module if the module is fully utilised to its capacity.
\n\n\nFigure 6\n explains the data flow in the deburring process. The data transfer occurs locally from the sensors and DAQ controller initially. DAQ controller preprocesses the sensor data and arrives at a decision based on the trained AI model. The DAQ controller feeds the decision output back to the robot controller via its digital-analogue I/O. In the branch of this local control loop, the preprocessed data is sent to the cloud in a suitable protocol with data encryption.
\nData path loop and DAQ to robot communication in deburring.
The implementation of data analysis to the cloud requires conversion of the machine learning algorithm to the cloud. Before moving into this, some fundamentals of the cloud services for Industry 4.0 implementation are explained to understand which platform is suitable for certain application.
\nThe current industrial practice of removing weld seam in manufacturing industry involves skilled operator using a belt sander. The component, when removed from the production for such operation, poses delay to the production cycle; fixturing, clamping, and unclamping cause a loss to the production volume. As an alternative, the belt grinder is integrated with the robot (in our case ABB6640). The tool path is programmed in the robot controller in such a way that weld seam and surrounding areas are blended. Machine vision-based solution is opted to analyse the state of the weld seam. If the weld seam is yet to be removed, the controller is triggered via flag setting through input/output pin. If the weld is removed, the controller is not triggered, and the completion message is sent.
\nAfter completion of each pass, the IP camera is triggered to capture the image of the component. The edge Pc that triggers image capturing knows the state of tool path as it is the constant communication with the robot controller via TCP/IP. The image acquired is then passed through a secured network on MQTT protocol to a MATLAB instance running on a virtual machine inside Azure cloud services. The MATLAB instance has the deep learning model-based encoder-decoder architecture on predicting the pixel-wise state of the weld seam. The result is sent back to the edge PC, which initiates the tool path again. The cycle continues as long as the weld seam is completely blended with the surrounding surface. The deep learning algorithm is trained using four different weld seam states. The edge PC triggers the robot controller to execute the tool path unless weld seam state four is reached, i.e. where the weld seam is wholly removed. The schematic flow of data connectivity and decision-making is shown in \nFigure 7\n.
\nData analytics for the IIoT architecture in the cloud for weld seam prediction.
In order to establish data collection and analysis through machine learning to predict the deburred surface quality, several equipment have to be prepared. \nTable 3\n lists the systems used in this paper. Meanwhile, the system configuration for deburring is described in \nFigure 8\n. In \nFigure 8\n, it can be seen that the controller is the core equipment whose functions are to collect the sensor data, analyse, control robot action, and upload the data to the server and cloud. Thus, DAQ controller specification is crucial to determine the performance of this framework adaptation for deburring in the production line.
\nEquipment | \nFunction | \n
---|---|
ABB robot | \nRobot for machining | \n
DAQ Controller | \nSensor data acquisition, analysis, and data transmission to the Internet | \n
Sensors | \nCollecting the variables required from the process for analysis | \n
Display | \nDisplaying the sensors data, analysis process, and result | \n
System for industry 4.0 implementation.
Deburring equipment configuration and data path.
After understanding the data collection, the next step is to understand how to implement machine learning model into deburring process. A schematic is made to understand how the machine learning model processes the sensor data in deburring and predicts the physical features such as chamfer length and surface finish.
\n\n\nFigure 9\n is the training phase to generate a model that correlates the input sensor data in deburring to the physical features measured on deburring work coupon as output. After the trained model satisfies the accuracy and repeatability required, the trained model is again implemented between the input and output. In the author’s previous journal paper, an example is discussed for the use of Welch’s estimate to compute power spectral density (PSD) to classify the number of passes and classify the vibration signal generated by the spindle based on adaptive neuro-fuzzy inference system (ANFIS) [18]. Meanwhile, in the second journal publication of this topic, the authors presented the results of fuzzy inference system (FIS) machine learning method to obtain the corresponding output as predicted surface finish quality of boss hole chamfer length and also the stage classification of deburring process [19]. A detailed result on feature extraction and machine learning method using ANFIS and FIS can be obtained from previous publications [18, 19]. A preliminary study of cloud computing to predict the output quality of deburring is presented in [19].
\nFuzzy inference system analysis model training on deburring.
An IP camera is introduced to capture the images of various stages of the weld seam. The IP camera is incorporated with the help of a tripod stand adjacent to the belt grinder. Surface images are captured at the end of every pass of robot arm across the weld seam (\nFigure 10\n). The camera system is capable of capturing and storing the surface images at a resolution of 1240 × 960 pixels. The images are subsequently labelled and sent to the Azure cloud with MATLAB Environment where the actual model training takes place. The variable grinding parameter used to remove weld seam is shown in \nTable 4\n.
\nAnalyse data in the Azure cloud with MATLAB [
Parameter | \nDescription | \n
---|---|
Belt grinding speed | \n5000–1100 RPM | \n
Contact wheel diameter | \n10 mm, 24 mm | \n
Hardness of contact wheel (polyurethane) | \nShore A Hardness 30, 60, 90 | \n
Lubrication | \nDry condition | \n
Feed | \n10–40 mm | \n
Belt finishing duration | \nVariable time | \n
Operational mode | \nPosition control | \n
Parameters used in the belt grinding experimental trials.
Azure’s in-built architecture incorporates best practices for creating a full MATLAB desktop experience on Azure. This includes connecting to Azure from your local desktop using Remote Desktop Protocol (RDP). It sets up a single virtual machine containing MATLAB, a private virtual network with an Internet gateway, a private subnet, and a security group that opens the appropriate ports for SSH and RDP access. For training and deploying, we will be using Azure cloud service as IaaS.
\n\n\nFigure 11\n shows in detail the implementation of encoder-decoder-based deep learning model in the cloud. In total, 2000 images taken using the IP vision system are labelled offline and stored in the cloud. The MATLAB instance is created in the cloud, and required resources for computing are generally chosen before the creation of VM on which the MATLAB instance runs. The deep learning model is defined to identify four weld seam states. The VGG-16 network is retrained to identify the weld seam states. Pixel label layer of the default VGG-16 network is replaced by the customised label layer that would identify the weld seam state and background of an image. Distribution of pixel count for four different belt states and background is identified, and the corresponding weight is redefined on the final layer of the VGG-16 network. The weld state identification was performed in MATLAB deep learning toolbox. The augmented training image set is used for training, and it is ensured that the training accuracy increases and training loss decreases with the iteration count. The training is terminated once the parametric conditions are met. Once the model is ready for deployment, IP camera sends the image frame at an interval of the 1-second interval through secure MQTT to the cloud during the actual belt grinding trials. The script in the cloud passes the image into the developed model to make the pixel-wise classification. It is to be noted that the transfer speed of images from edge to cloud depends on the network traffic. The pixels’ classified image is sent back to the edge PC for visualisation through MQTT secure network.
\nGeneral description of the proposed methodology to train and deploy the model in azure cloud.
Two case studies related to the machine learning, deep learning, and cloud computing application towards smart manufacturing has been presented in this work. A methodology for integrating brownfield systems into IIoT framework to facilitate industry 4.0 adaptation is demonstrated. A simple data flow pipeline has been established between the edge and cloud framework via MQTT protocol. Cloud framework based on IaaS is used to deploy the deep learning model. However, it is to be noted that other protocols similar to MQTT can also be used for data transfer. The deployment of a robust analytical architectural framework cannot be just restricted to putting data processing and analysis software in place at cloud and edge. As a plant expands, the analytical framework and supporting hardware need to evolve organically. The framework should also support repeated installations and setup procedures being carried out simultaneously for brownfield equipment as well as systems with in-built IoT. Caution should also be exercised while amalgamating the analytical solution in cloud for existing legacy systems, in order to preserve their security and integrity.
\nThe authors declare no conflict of interest.
Streptococcal skin and skin-structure infection (SSTI) is associated with significant morbidity all over the world and the impact is felt predominantly in resource-poor areas with inadequate personal hygiene and over-crowded living conditions. While exact numbers are difficult to estimate on account of the lack of systematic reporting, a literature search conducted by Sims and colleagues [1] reported an estimated prevalence of 18 million cases, with an incidence rate of around 1.78 million cases per year of invasive
Skin infections have been variously classified based on different criteria like depth of infection or the bacterial agents causing the infections or as primary infection in contrast to infection of pre-existing wounds or skin conditions. A very practical classification of patients hospitalized with skin infections (cellulitis versus abscess versus skin infections with additional complicating factors) has been described by Jenkins et al. [6]. The authors found in their study that cutaneous abscesses were primarily caused by
The clinical features of common streptococcal SSTIs and the antibiotics used in the management of these conditions will be further elaborated in this chapter.
Superficial skin infection has been described as
Impetigo secondary to infected contact dermatitis.
Antiseptic soaks and antibacterial creams are the mainstay of therapy for impetigo. A wide variety of topical antimicrobial agents are available including silver-based products, iodides, hydrogen peroxide, zinc, chlorhexidine and potassium permanganate. There is very little data in the literature comparing benefits of one product versus the other [7, 8]. Antibacterial creams: mupirocin, Na-fusidate and bacitracin are also available for use in localized superficial skin infections [9]. Drawbacks of topical therapy include development of resistance, risk of irritant or allergic dermatitis (sensitization), and if used in high concentrations, these could cause burn injuries.
When skin infection results in erythematous (red in color), edematous (raised above the surface) and well demarcated (sharp boundary between involved and uninvolved skin) areas of involvement, it is referred to as
Erysipelas with sharply-defined edematous red skin lesions.
When streptococcal infection involves the skin as well as the subcutaneous tissue, it results in ill-defined areas of erythema that are rapidly spreading and this is called
Cellulitis with irregular and ill-defined borders.
Fungal infection in the webspace of the toes, also called “athlete’s foot.”
Lymphangitic streaking of the upper extremity.
Lymphangitic streaking (double) of the lower extremity.
In some patients there is an overlap between erysipelas and cellulitis and the clinical differences are not so clear. Importantly, management of both conditions is similar.
Mild localized infections are treated with oral antibiotics, while more extensive infections or infections with systemic symptoms are treated with parenteral (intravenous) antibiotic therapy [14]. Patients with signs of sepsis: fever or hypothermia, tachycardia and hypotension, and patients with underlying conditions like uncontrolled diabetes, liver cirrhosis, severe peripheral vascular disease or severe lymphedema and patients with immunocompromising conditions like HIV, or patients on chemotherapy should be admitted to the hospital for antibiotics as well as aggressive management of the underlying conditions. Penicillins and β-lactams are considered the antibiotics of choice for treatment of streptococcal cellulitis. The addition of a second antibiotic like trimethoprim/sulfamethoxazole (TMP/SMX) or clindamycin has been shown to provide no additional benefit [6, 15, 16, 17, 18]. Penicillins are available in the form of oral as well as intravenous preparations (Table 1). Extended spectrum penicillins: dicloxacillin, amoxicillin, ampicillin, oxacillin and nafcillin can be used if there is associated methicillin susceptible
Name | Dosage | Comments |
---|---|---|
Oral agents | ||
Penicillin VK | 250–500 mg, 4 times a day | |
Dicloxacillin | 250–500 mg, 4 times a day | Effective also against MSSA |
Amoxicillin | 500 mg, 3 times a day | Effective also against MSSA |
Intravenous agents | ||
Penicillin G | 2–4 million units, q 4–6 h | Also available as continuous infusion via pump |
Ampicillin | 2 g, q 4–6 h | Effective also against MSSA |
Oxacillin, Nafcillin | 1–2 g, q 4–6 h | Effective also against MSSA |
Piperacillin-tazobactam* | 4.5 g, q 8 h | Effective also against MSSA, |
Penicilins.
Require dose adjustment in patients with kidney disease.
Name | Dosage | |
---|---|---|
Oral cephalosporins | ||
1st generation | cephalexin | 500 mg, 4 time a day |
2nd generation | cefaclor | 500 mg, 3 times a day |
cefuroxime | 500 mg, 2 times a day | |
3rd generation | cefpodoxime | 200 mg, 2 times a day |
Intravenous cephalosporins | ||
1st generation | cefazolin | 1–2 g, q 8 h |
3rd generation | ceftriaxone | 1–2 g, q 24 h |
5th generation | Ceftaroline | 600 mg, q 12 h |
Carbapenems (Intravenous) | ||
Imipenem | 0.5–1 g q 6 h | |
Meropenem | 1–2 g, q 8 h | |
Ertapenem | 1 g, q 24 h |
β-Lactam antibiotics used for streptococcal skin infections.
Effective also against MSSA. Ceftaroline is also effective against MRSA.
All (except ceftriaxone) require dose adjustment in patients with kidney disease.
Name | Drug class | Dose | Comments |
---|---|---|---|
Oral agents | |||
TMP/SMX* (160 mg/800 mg) | Sulphonamide | 1–2 tabs, 2 times a day | Effective also against MSSA, MRSA |
Watch for rash, monitor cbc, creatinine | |||
Doxycycline, Minocycline (100 mg) | Tetracycline derivative | 1 tab, 2 times a day | Effective also against MSSA, MRSA |
Risk for sunburn, pill esophagitis | |||
Linezolid (600 mg) | Oxazolidinone | 1 tab, 2 times a day | Effective also against MSSA, MRSA |
Avoid co-administration with SSRI, MAO inhibitors | |||
Risk for cytopenias, neuropathy | |||
Excellent oral-parenteral bioavailability | |||
Clindamycin (300 mg) | Lincosamide | 300–450 mg, 4 times a day | Effective also against MSSA, MRSA |
Highest risk for CDiff infection | |||
Ciprofloxacin, levofloxacin, moxifloxacin | Fluoroquinolone* | Different doses for different agents | Effective also against MSSA |
Risk for tendon injury, CNS side effects in the elderly, CDiff infection | |||
Intravenous agents | Effective also against MSSA, MRSA | ||
Vancomycin* | Glycopeptide | 15–20 mg/kg q 12 h | Close monitoring of levels to avoid nephrotoxicity. Red-man syndrome if administered too fast |
Daptomycin* | Cyclic lipopeptide | 4–6 mg/kg q 24 h | Risk of rhabdomyolysis, Esosinophilic pneumonia |
Linezolid | Oxazolidinone | 600 mg q 12 h | Avoid co-administration with SSRI, MAO inhibitors |
Risk for cytopenias, neuropathy | |||
Tigecycline | Tetracycline derivative (glycylcycline) | 100 mg X 1, then 50 mg q 12 h | Effective also against anaerobes |
Risk for Nausea |
Non β-lactam antibiotics used for streptococcal skin infections.
Require dose adjustment in patients with kidney disease.
Name | Drug class | Dose | Comments |
---|---|---|---|
Dalbavancin | Lipo-glycopeptide | Intravenous: 1.5 g single dose | One dose IV provides 2 weeks of therapy |
Oritavancin | Lipo-glycopeptide | Intravenous: 1.2 g single dose | One dose IV provides 2 weeks of therapy |
Delafloxacin | Fluoroquinolone | Intravenous: 300 mg q 12 h Oral: 450 mg twice a day | Allows transition from IV to oral. Risks as with other FQ |
Omadacycline | Tetracycline derivative | Intravenous: 200 mg X 1, then 100 mg daily Oral: 450 mg once a day for 2 days, then 300 mg once a day | Allows transition from IV to oral. Gastrointestinal side effects. Effective also against anaerobes |
Tedizolid | Oxazolidinone | Intravenous: 200 mg, q 24 h Oral: 200 mg once a day | Allows transition from IV to oral. Risk for cytopenias, neuropathy |
Newer antibiotics approved for treatment of skin infections.
Effective also against MSSA, MRSA.
When streptococcal infection spreads deep beyond the subcutaneous tissue, it can result in extensive necrosis (gangrene) of the overlying skin and inflammation and necrosis of underlying fascia
Necrotizing fasciitis of the lower extremity.
Clinical photograph showing erythema, peeling skin, dusky hue and areas of necrosis.
Necrotic areas with skip lesions on leg of patient who is abusing self with injection drugs.
When infection spreads beyond the fascial planes into the underlying muscles it is called myositis.
Necrosis of skin, soft tissue and muscle with exposure of tendon.
Patients need admission to the hospital often to the intensive care unit. They require management by a team of experts involving medical, surgical, infectious diseases and critical care specialties. They often present with septic shock and require pressors like epinephrine, norepinephrine and vasopressin to maintain adequate blood pressure in order to perfuse critical organs. Patients require broad spectrum antibiotic coverage, aggressive fluid resuscitation, as well as emergent aggressive debridement of the infected areas. Surgical removal of infected/necrotic tissue is essential in order to reduce bacterial burden and hence remove the source of toxins. Often patients require a second or even third visit to the operating room because of extensive tissue necrosis not amenable to removal in a single operation [14]. Operative tissue is sent for microbiology (cultures) to help determine the infectious agent and obtain an antibiotic sensitivity profile to help guide appropriate antibiotic choices. While awaiting the results of cultures, the antibiotics chosen should cover Gram-positive bacteria including
TSS is associated with a dramatic widespread skin rash and severe systemic symptoms. This condition is not due to direct inoculation of the skin with
Clinical photograph of sheet of erythema seen in acute phase of toxic shock syndrome.
Toxic shock syndrome with desquamation in the recovery phase.
As with other severe streptococcal infection, patients with TSS require admission to the hospital. If they are hypotensive or experience multi-organ failure, management is in the intensive care unit where patients are treated with aggressive fluid resuscitation, broad antibiotic therapy (choices similar to that as described for management of necrotizing fasciitis) and pressor support. Surgery may be required if a deep focus of infection is identified. Rarely patients do not respond to standard therapy and may require intravenous immunoglobulins (IVIG) [36].
Streptococcal SSTIs respond very well to antibiotic therapy. A wide range of antibiotics with excellent skin penetration are now available as noted in Table 1–4. All antibiotics carry the potential for side effects like allergic reactions and gastrointestinal disturbances. There are some side effects that are unique to certain antibiotics and patients need to be monitored for these toxicities. For example: β-lactam antibiotics have the potential for hepatotoxicity, vancomycin is associated with nephrotoxicity, daptomycin can cause rhabdomyolysis and eosinophilic pneumonitis and clindamycin is one of the most common antibiotics associated with
Mild infections should be treated with oral antibiotics.
Severe infections (severe local skin infection with systemic symptoms like fever, tachycardia, hypotension or leukocytosis and bacteremia, or more extensive skin infections even without systemic symptoms) will require parenteral therapy, with step-down to oral therapy as the patient improves [40]. Antibiotics like the floroquinolones: ciprofloxacin, levofloxacin, delafloxacin [41, 42], moxifloxacin [43], the oxazolidinones: linezolid, tedizolid and the new tetracycline: omadacycline [44] have excellent oral bioavailability and allow early conversion from intravenous to oral therapy.
In the most serious cases: sepsis, septic shock, necrotizing fasciitis, myositis, toxic shock syndrome: broad-spectrum antibiotics are required initially (most often with more than one antimicrobial agent) to cover
Duration of antibiotics: This depends on the severity of the infection as well as the clinical response to therapy. Mild infections or even severe infections in an otherwise healthy host that respond rapidly to antibiotics could be treated for as short as 5 days [14, 45, 46]. More severe infections or infections with a delayed response to therapy may need longer courses like 7, 10 or 14 days, depending upon the clinical picture. Shorter courses may be possible with some of the newer antibiotics including single dose antibiotics like dalbavancin [47] and oritavancin [28]. Relapses are found to be more common in patients with shorter courses of therapy [45]. Patients with bacteremia are usually treated for 14 days.
Dose adjustments: Antibiotics are cleared by the liver or kidney and hence dosage needs to be reduced in patients with liver or kidney disease in order to avoid toxicity. Conversely, patients who are obese require a higher dose of the antibiotic to achieve therapeutic levels in the skin [25, 48].
Suppressive therapy is attempted for patients with multiple recurrences [45, 49, 50]. Oral penicillin twice daily showed a 70–80% reduction in episodes—but recurrences occurred after discontinuation of prophylaxis. Treatment of underlying factors like athlete’s foot, chronic lymphedema, peripheral vascular disease and uncontrolled diabetes is also very important in the prevention of recurrences [11, 44, 45, 51]
Streptococcal skin infections cause significant morbidity all over the world, and severe infections like necrotizing fasciitis and toxic shock syndrome can be fatal. There is a wide spectrum of manifestations of skin infections ranging from mild superficial disease to deep necrotic and life-threatening infections. Skin infection is one of the most common reasons for prescriptions of antibiotics in the community as well as in hospitalized patients. Some of the most commonly used antibiotics have excellent skin penetration and hence the armamentarium to treat skin infections is quite large. Over the last few years there have been multiple new antibiotics approved for the treatment of skin infections and these should be reserved for treatment of severe infections not responding to the common antibiotics and for infections with multi-drug-resistant organisms. A thorough understanding of the different types of skin infections, as well as a detailed knowledge of the different antibiotics are essential for the early diagnosis and selection of the most appropriate antibiotic for the management of simple as well as complex skin infections.
Intro
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. 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Additional details are presented related with the mechanical and functional integration of the GPR into the UAV system.",book:{id:"5905",slug:"robots-operating-in-hazardous-environments",title:"Robots Operating in Hazardous Environments",fullTitle:"Robots Operating in Hazardous Environments"},signatures:"Manuel Ricardo Pérez Cerquera, Julian David Colorado Montaño\nand Iván Mondragón",authors:[{id:"177422",title:"Dr.",name:"Julian",middleName:null,surname:"Colorado",slug:"julian-colorado",fullName:"Julian Colorado"},{id:"197884",title:"Prof.",name:"Ivan",middleName:null,surname:"Mondragon",slug:"ivan-mondragon",fullName:"Ivan Mondragon"},{id:"199958",title:"Prof.",name:"Manuel",middleName:null,surname:"Perez",slug:"manuel-perez",fullName:"Manuel Perez"}]},{id:"67705",title:"Advanced UAVs Nonlinear Control Systems and Applications",slug:"advanced-uavs-nonlinear-control-systems-and-applications",totalDownloads:1971,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Recent development of different control systems for UAVs has caught the attention of academic and industry, due to the wide range of their applications such as in surveillance, delivery, work assistant, and photography. In addition, arms, grippers, or tethers could be installed to UAVs so that they can assist in constructing, transporting, and carrying payloads. In this book chapter, the control laws of the attitude and position of a quadcopter UAV have been derived basically utilizing three methods including backstepping, sliding mode control, and feedback linearization incorporated with LQI optimal controller. The main contribution of this book chapter would be concluded in the strategy of deriving the control laws of the translational positions of a quadcopter UAV. The control laws for trajectory tracking using the proposed strategies have been validated by simulation using MATLAB®/Simulink and experimental results obtained from a quadcopter test bench. Simulation results show a comparison between the performances of each of the proposed techniques depending on the nonlinear model of the quadcopter system under investigation; the trajectory tracking has been achieved properly for different types of trajectories, i.e., spiral trajectory, in the presence of unknown disturbances. Moreover, the practical results coincided with the results of the simulation results.",book:{id:"7792",slug:"unmanned-robotic-systems-and-applications",title:"Unmanned Robotic Systems and Applications",fullTitle:"Unmanned Robotic Systems and Applications"},signatures:"Abdulkader Joukhadar, Mohammad Alchehabi and Adnan Jejeh",authors:null},{id:"60953",title:"Small to Medium UAVs for Civilian Applications in Indonesia",slug:"small-to-medium-uavs-for-civilian-applications-in-indonesia",totalDownloads:1339,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Indonesian government needs a well-built, easy to operate unmanned aircraft systems (UAS) to perform various civilian missions as UAS are a well-known platform for dirty, dull, and dangerous missions. Hence, the Indonesian government has an organization that performs research and development of UAS, named as Aeronautic Technology Center. This organization is placed underneath Indonesian National Institute of Aeronautics and Space. The UAS developments in this institute are primarily driven by civilian uses; therefore, the UAS size, sensor types, and mission payload are optimized for civilian missions. In order to produce the decent to the best quality of the aerial image, which is the essential product for various civilian missions, the UAS regularly flies under the cloud. For this reason, the Aeronautic Technology Center is only developing the LASE (low altitude, short-endurance) and the LALE (low altitude, long endurance) UAS type as of now. The UAS development was begun with LSU-01, followed by LSU-02, LSU-03, and LSU-05. The LSU-01, LSU-02, and LSU-03 are in the operational phase, while the LSU-05 is in the experimental Phase. In this chapter, the specification of the platforms and the sensor capabilities that are relevant with the demands of users in the civilian sector are described.",book:{id:"6465",slug:"drones-applications",title:"Drones",fullTitle:"Drones - Applications"},signatures:"Fuad Surastyo Pranoto, Ari Sugeng Budiyanta and Gunawan Setyo\nPrabowo",authors:[{id:"223333",title:"M.Sc.",name:"Fuad",middleName:"Surastyo",surname:"Pranoto",slug:"fuad-pranoto",fullName:"Fuad Pranoto"},{id:"223356",title:"MSc.",name:"Ari Sugeng",middleName:null,surname:"Budiyanta",slug:"ari-sugeng-budiyanta",fullName:"Ari Sugeng Budiyanta"},{id:"223357",title:"MSc.",name:"Gunawan Setyo",middleName:null,surname:"Prabowo",slug:"gunawan-setyo-prabowo",fullName:"Gunawan Setyo Prabowo"}]},{id:"67003",title:"Vision-Based Autonomous Control Schemes for Quadrotor Unmanned Aerial Vehicle",slug:"vision-based-autonomous-control-schemes-for-quadrotor-unmanned-aerial-vehicle",totalDownloads:978,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"This chapter deals with the development of vision-based sliding mode control strategies for a quadrotor system that would enable it to perform autonomous tasks such as take-off, landing and visual inspection of structures. The aim of this work is to provide a basic understanding of the quadrotor dynamical model, key concepts in image processing and a detailed description of the sliding mode control, a widely used robust non-linear control scheme. Extensive MATLAB simulations are presented to enhance the understanding of the controller on the quadrotor system subjected to bounded disturbances and uncertainties. The vision algorithms developed in this chapter would provide the necessary reference trajectory to the controller enabling it to exercise control over the system. This work also describes, in brief, the implementation of the developed control and vision algorithms on the DJI Matrice 100 to present real-time experimental data to the readers of this chapter.",book:{id:"7792",slug:"unmanned-robotic-systems-and-applications",title:"Unmanned Robotic Systems and Applications",fullTitle:"Unmanned Robotic Systems and Applications"},signatures:"Archit Krishna Kamath, Vibhu Kumar Tripathi and Laxmidhar Behera",authors:null},{id:"59130",title:"The Use of Unmanned Aerial Vehicles by Urban Search and Rescue Groups",slug:"the-use-of-unmanned-aerial-vehicles-by-urban-search-and-rescue-groups",totalDownloads:1294,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"In the case of natural or man-made disaster, the top priority of urban search and rescue (USAR) groups is to localise the victim as quickly as possible. Even minutes might play a crucial role in the victim’s survival. A number of standard operating procedures may be applied to achieve best performance. Rescue dogs are trained to search for alive victims; special inspection cameras are used, before heavy equipment is being implemented. To improve the effectiveness of USAR group operations, innovative technologies might be implemented. The most recent solution is currently designed in MOBNET project, founded by EU under the Horizon 2020 programme. The scope of the project is to combine both cellular technology and early Galileo services to localise the smartphones of potential victims. Integration tests give some promising outcomes. The following chapter looks at typical applications, real needs of public services as well as the performance of the novel system.",book:{id:"6465",slug:"drones-applications",title:"Drones",fullTitle:"Drones - Applications"},signatures:"Marzena Półka, Szymon Ptak, Łukasz Kuziora and Aneta Kuczyńska",authors:[{id:"226977",title:"Dr.Ing.",name:"Szymon",middleName:null,surname:"Ptak",slug:"szymon-ptak",fullName:"Szymon Ptak"},{id:"240085",title:"Prof.",name:"Marzena",middleName:null,surname:"Półka",slug:"marzena-polka",fullName:"Marzena Półka"},{id:"240086",title:"MSc.",name:"Łukasz",middleName:null,surname:"Kuziora",slug:"lukasz-kuziora",fullName:"Łukasz Kuziora"},{id:"240087",title:"MSc.",name:"Aneta",middleName:null,surname:"Kuczyńska",slug:"aneta-kuczynska",fullName:"Aneta Kuczyńska"}]}],onlineFirstChaptersFilter:{topicId:"242",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. 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He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. 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Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. 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He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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