\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"892",leadTitle:null,fullTitle:"Seismic Waves - Research and Analysis",title:"Seismic Waves",subtitle:"Research and Analysis",reviewType:"peer-reviewed",abstract:"The importance of seismic wave research lies not only in our ability to understand and predict earthquakes and tsunamis, it also reveals information on the Earth's composition and features in much the same way as it led to the discovery of Mohorovicic's discontinuity. 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Gensure",coverURL:"https://cdn.intechopen.com/books/images_new/10312.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"16515",title:"Dr.",name:"Robert",middleName:null,surname:"Gensure",slug:"robert-gensure",fullName:"Robert Gensure"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11433",leadTitle:null,title:"Human Migration in the Last Three Centuries",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tIn March 2022, another book on human migration seems important when the events or tragedies unfolding in Eastern Europe are considered. People have always migrated and have moved, but, specifically looking at the last three hundred years, involuntary migration is on the rise. Involuntary migration does not only affect Europe; Asia, Africa, and North as well as South America, have had their fair share of natural catastrophes, invasions, and wars.
\r\n\tThis book will intend to look at different migrant patterns, voluntary and involuntary migration, over the last three centuries. What influenced people to leave their home countries, family, and friends and settle somewhere else? The book may include histories of the 19th century, consider tragedies and movements activated by political events in the 20th century, and/or look at recent events of the 21st century. Push and pull factors are important points. While most of us may be influenced in a negative way by the current happenings in Eastern Europe, the Russian invasion and resulting tragedies also demonstrate some very positive human traits – the preparedness of Ukraine’s surrounding countries to help those in need and to provide a safe place for the present.
\r\n\tWhether one looks at voluntary or involuntary migration into any country, after a period of adjustment, migrants do play a positive role. The research found that migrants contribute to the economy (food, shelter, employment, tax) and enrich a country’s cultural norms. Prerequisites for successful settlements are that the host society adopts a tolerant approach and that the migrants recognize the law and the language of the host country. Nothing is ever easy or without controversy, but I am a migrant (German Australian), and life in Australia has been relatively harmonious. Issues that could be considered in the book are multicultural societies (do monocultural societies still exist?) and theories of acculturation versus integration (settlement processes).
\r\n\tTwo further issues are very important in relation to human migration. There is climate change, global warming, and the environment, which clearly affect people’s movement. Small island populations are very concerned about rising sea levels. 2021 has also seen floods costing human lives: Turkey (August 2021), Brazil (December 2021), Chile (January 2021), and South India (November 2021), to name but a few. In Australia (March 2022), farms and whole townships in New South Wales and Queensland have been flooded for the second time in five years, and plans to resettle these towns are considered. Official and social media provide ample coverage of the events, which leads me to the next issue. There is today’s very important role of the media, of the official and social media. We are constantly bombarded with images of human war tragedies and flood victims. People in industrialized, western countries must be the best-informed populace. How far do the images and up-to-date TV news influence us, make us change our behavior, and perhaps even consider us more generous than we have been?
\r\n\tClimate change and the media are relatively new to the human migration debate, but both issues play important parts, and some interesting discussions are appreciated.
\r\n\t
Adequate soil physical and hydrological conditions are key conditions for full plant development, which is a premise for coffee quality exportation due to requirements for grain quality and crop uniformity [1]. However, in the main coffee producing region of Brazil, there have been severe droughts. Although soils are mostly deep and able to store a large volume of water, they present small effective depth for the development of the root system, resulting in the edaphic drought, which has brought many losses to coffee farmers. This situation is aggravated in soils of oxide mineralogy and with very small granular structure, which condition the formation of pores with extreme diameters [2]. Thus, it leads to very rapid loss of water stored in very large pores, or to its strong retention in extremely small pores.
A number of measures have been sought by Brazilian researchers to solve the problems, such as selecting drought tolerant plants [3, 4]. However, a measure that has attracted the attention of most producers is the adoption of soil management systems that provide the best development of the root system of coffee crops and physical-hydrological adequacy of the soil.
Therefore, this chapter will discuss the main limitations of soils used in the main coffee growing area of Brazil and the mitigation techniques for soil suitability based on research that have been developed for over a decade.
In the past, coffee cultivation was traditionally performed in grooves of 0.40 m × 0.40 m × 0.40 m. From the 1970s, the use of furrows for planting coffee was introduced in large scale. These furrows, open with tractors and with small furrowers, were shallow at 0.30–0.40 m deep and V-shaped, with small width at the bottom. For these reasons, and also due to the fact that under conventional coffee growing conditions soil fertilization was performed on the surface layers, much of the root system was limited to the first 0.40 m depth [5].
With the advancement of knowledge and technologies, it has been found that coffee roots can reach depths well above 1 m when in the absence of physical limitations and when adequate chemical conditions [6, 7, 8], such as sufficient calcium, phosphorus and boron contents, are provided [9].
With the development of new soil preparation tools, coffee farmers have been adopting deep furrow associated with soil correction and/or fertilization [10]. In the south and southwest regions of the state of Minas Gerais, deep tillage has often been carried out, allowing the incorporation of phosphate or limestone to a depth of 0.90 m. Due to higher soil turnover, larger amounts of fertilizer can be added in the furrow, correcting the soil in deeper layers and providing a better environment for coffee root development [6, 7, 10, 11].
Coffee cultivation using deep tillage system associated with surface application of additional doses of gypsum presents better drought resistance when compared with crops planted using conventional system, which conditions the permanence of the root system on the soil surface. Regarding the additional operation costs, the practice of deep tillage is compensated by the high crop yields in the first harvest [12]. Nevertheless, there are large variations in production costs, especially considering the price of the product.
Gypsum (CaSO4.2H2O) is considered a good soil conditioner due to its high mobility in the soil profile, providing calcium and sulfur to the plants, as well as acting as a deep corrective for toxic aluminum (Figure 1) [13].
Contents of Al3+ (a), Ca2+ (b) and effective CEC (c) in red Latosol under conventional management and after 11 years of deep preparation conservation system and application of 28 Mg ha−1 of gypsum. Source: From authors.
The ability of gypsum to increase Ca2+ levels in the deepest soil layers is important for the proper development of the crop root system, especially because Ca2+ is the main component of the cell wall, being responsible for root elongation and growth [6, 7, 8].
The increase in effective CEC of the subsurface layers in management systems in which gypsum is applied is due to the increase in soil organic matter (SOM) (Figure 2). Coffee is mostly grown intercropped with Brachiaria between rows [10]. This grass is periodically mowed and its residues remain in the coffee line, representing continuous input of organic matter to the soil [8]. Thus, SOM contributes to increased CEC and improved nutrient utilization efficiency by providing a significant number of binding sites for essential elements present in the soil [14].
Average values of organic carbon contents (g kg−1) in red Latosol under conventional management and after 11 years in deep preparation conservation system and application of 28 Mg ha−1 of gypsum. Source: From authors.
Studies showed that up to 21% of the carbon added by the roots could be incorporated into SOM [15]. Thus, the biomass of the coffee root system itself, favored by calcium, is also a source of organic matter for the soil and certainly contributed to raise the CEC (Figure 1).
Moreover, this management system can be considered efficient in the construction of fertility of Latosols, whose mineralogy is dominated by low chemical activity clay minerals (kaolinite and iron and aluminum oxides in the form of goethite, hematite and gibbsite). In these soils, which are typical of the Brazilian Cerrado biome, organic matter can contribute to up to 80% of negative soil loads [16].
Due to intense soil revolving, tillage management systems promote aggregate breakage, leading to significant structural changes [10, 12, 17]. However, by evaluating a Cambisol after 6 months of implantation of the coffee crop, Serafim et al. [17] observed a reduction in soil density and an increase in total porosity due to the benefits conditioned by the structural relief and construction of soil fertility. Serafim et al. [10] described the presence of coffee root system with average depth in the soil profile of 0.80 and 0.60 m at 6 months after planting for Latosol and Cambisol, respectively. After 1 year, the root system reached 1.40 m in Latossol and 1.20 m in Cambisol.
Serafim et al. [18], using the Least Limiting Water Range (LLWR) technique, found that a Cambisol presented no physical-water limitations after 3.5 years of coffee plantation and the crop implanted in this soil reached productivity much higher than the average of the state of Minas Gerais. It evidences the longevity of the positive effects of deep tillage on soil physical properties. Moreover, Serafim et al. [10, 17, 18, 19] and Silva [20] observed positive responses in soil physical properties, such as increase in the volume of large macropores (>147 μm), fine macropores (147–73 μm) and large mesopores (73–49 and 49–29 μm), when evaluating the physical quality of this soil after 5 years of tillage implementation. Similarly, Silva et al. [21] observed a significant increase in LLWR and a significant reduction in soil density when evaluating the structural quality of very clayey Latosol after 2 years of coffee cultivation.
Silva et al. [8] found a significant volume of inter-aggregate pores (macropores) after 3 years of coffee cultivation in Latosols, confirming the benefits of the management system using deep preparation associated with surface gypsum application. In the layer between 0.20–0.40 m of the soil, even after 5 years of cultivation, Silva [20] also found that soil management favored the expressive increase of pore volume of classes 9.0–2.9, 2.9–0.6 and 0.6–0.2 μm (mesopores), which is relevant since a good portion of the water retained in the soil will be available to the plants.
Particularly in Latosols under this management system, it was observed that in the absence of chemical and physical limitations of the soil the coffee root system reached depths greater than 1 m at 3 years of age (Figure 3), which is of fundamental importance to ensure crop survival in periods of edaphic drought [8].
Area occupied by coffee plant roots along the profile of Rhodic Haplustox. Source: Adapted from Silva et al. [
Serafim et al. [19] evidenced intense water deficit up to 1.60 m in the crop line, when monitoring moisture of a very clayey and oxidic Latosol with 3.5 years of cultivation in a dry year. The authors attributed the results to the presence of roots that used intensely the available water in this depth of soil. Very thin roots were found in the soil layer between 1.50 and 1.70 m, indicating potential for water use in these deeper soil layers.
Similarly, in Cambisol, Serafim et al. [19] also showed more intense drying in the crop line up to 1.6 m caused by the roots of the plants, since active roots were found in this depth. The authors reported that although the crop does not have water availability in the layers closer to the surface in the dry period of the year, the larger volume of soil explored by the roots contributed to reduce the water deficit.
Given the above, it is noteworthy that although the benefits of mechanical soil revolving are readily apparent in coffee cultivation after 4 years of management [6, 7, 10, 17, 18, 19], studies show that these effects do not last long in some soil classes [22]. In this sense, particularly when soil is revolved, physical improvements to the soil may be temporary, since the durability of the changes depends on the texture and mineralogy of the soil [23].
Silva [20] reported that the deep tillage and gypsum management system was not effective in providing improvements in the physical quality of a Nitisol, since in the 0.0–0.20 m and 0.40–0.60 m layers, management provided a decrease in the volume of large macropores (>145 μm), which may affect the internal drainage of the profile. According to the author, in soils presenting textural B-horizon, the physical conditioning provided by soil preparation is short and the soil tends to reconsolidate. It is possible that clay illuviation may be acting in this process, as observed in Argisol by Marcolan and Anghinoni [24]. When soils are prepared there is a breakdown of aggregates, and an increase in soil clay dispersion [25].
Still regarding the development of the root system in Latosols, the practices employed in the management system described by Serafim et al. [10] also contributed to the coffee root growth, even in young (<3 years) roots [7], which are responsible for rapid water absorption and increased nutrient acquisition [26] (Figure 4).
Root length distribution (mm) in (A) gibbsitic Acrustox and (B) kaolinitic Haplustox both with the multipractice conservation management system for the coffee crop. Source: Adapted from Carducci et al. [
The better distribution of the coffee root system in Latosol with high levels of gibbsite was promoted not only by the employed management system but also by the good distribution of well-connected pore diameters typical of this soil class (Figures 4 and 9). In kaolinitic Latosol, the system promoted the relief of the denser original structure, formed by thin and elongated pores promoted by the kaolinite mineral [27, 28], due to deep revolving associated with the addition of organic matter and gypsum, which favored concentrated root growth up to 0.80 m, but with regular root expansion with 500 mm length to 1 m depth (Figure 4) [7].
A well-distributed coffee root system along the soil profile, as observed in Figure 4, enhances the use of stored water available at greater depths (>0.80 m). Serafim et al. [19] and Silva et al. [29] reported the possibility of more efficient water absorption, minimizing the effects of water stresses to which these plants are subjected when cultivated in soils from the Cerrado biome, without harming crop yields [21]. Thus, knowledge about the distribution of coffee root system, as well as the probable changes in soil structure is the result of the interaction between the management system and the edaphoclimatic conditions that are intrinsic to Latosols.
The proper management of soil corrections and conditioning, dose adjustments and phosphorus use by the system, as well as balance in nutrient supply and leaf analysis for monitoring coffee nutrition are the main challenges of modern and competitive coffee cultivation for better use of available water in the soil–plant system [30]. Therefore, it is necessary to build soil fertility for sustainable coffee production in order to obtain increased nutrient use efficiency, increased fertilizer recovery rate, reduced biennial bearing and higher yield.
Coffee cultivation intercropped with
The part of the coffee root system responsible for the absorption of water and nutrients, the thinnest roots, usually deepens to a depth of 40 cm [5] (Figures 5 and 6). After a few years of planting under sufficient fertilizer application, some soil-moving nutrients such as nitrogen (N), potassium (K), sulfur (S) and boron (B) can leach beyond these absorbing roots. Thus, intercropping with deep-rooted plants practically all year round returns these nutrients to the surface of the soil–plant system. Therefore, managing between rows that collaborate with the proper management of soil fertility will certainly provide higher yields of coffee crop [35] due to the higher nutritional efficiency of the system production.
Density of coffee roots as a function of the sampling site, below the canopy, below the fertilizer range, and in the center of the row. Source: Adapted from Motta et al. [
Root system (A) and aerial part (B) of productive coffee, with good management of soil fertility construction in association with Brachiaria. Photo: Paulo T. G. Guimarães.
In addition, Brachiaria presents a root system that complements the efficiency of soil fertility use in the intercropping with the coffee as they explore depths of up to nearly 5 m (Figure 7).
Root system of
In coffee cultivation intercropped with Brachiaria, plant residues are recycled and used as nutrients for coffee nutrition. The amount and regularity of plant residue addition is more important than the synchronization between release and nutrient demand by coffee because the increase in organic matter content over the years.
Brachiaria is more efficient than the coffee tree to extract the phosphorus from the soil, which will be available gradually with the decomposition/mineralization of the straw in the canopy projection. Over the years, the grass also incorporates this nutrient in depth as its root system develops in a larger volume of soil (Figure 7).
It is possible to estimate three plant cuts per cycle, with 5 tons of dry matter per hectare in each field based on Brachiaria average productivity data [37] and proportional adjustment of its soil exploration area in consortium with the coffee tree (up to 30% of the area). The nutritional contents in dry matter for each coffee brush operation are: 75 kg of N; 20.6 kg P2O5; 193 kg of K2O; 24.4 kg of CaO; 20.8 kg of MgO; 3.5 kg of S-SO4; 90 g of B; 55 g of Cu; 1 kg of Fe; 475 g of Mn, and 400 g of Zn [34]. For the availability of these nutrients in the crop cycle, it is necessary to mineralize the dry matter, which depends on the presence of water, temperature and microorganisms in the soil, since some nutrients, such as N and P, are partially released over a period of 3 years [38].
Despite the many advantages presented by the cultivation of Brachiaria between coffee lines, there may be some disadvantages, especially if the coffee grower handles it incorrectly. Under conditions of severe water deficit, there may be competition for water and nutrients, harming the crop of commercial interest [39]. There may also be competition for nutrients and light and it is recommended to provide adequate and balanced coffee nutrition, as well as to maintain a strip of about 0.40 m on each side of the coffee trees, free from competing plants, and covered by residues from Brachiaria (Figure 8).
Appropriate management of rows of coffee plants with Brachiaria after mowing. Photo: Geraldo C. Oliveira.
Coffee cultivation intercropped with Brachiaria is one of the practices of building soil fertility in profile for greater sustainability of coffee growing. The addition of this grass to the cultivation system is necessary for greater use of water and soil nutrients, which also allows the suppression of other difficult to control weeds, presenting several benefits for better coffee development and productivity and consequently greater profitability.
The presence of an ideal pore network with a wide range of diameters is one of the key factors for high crop yields, especially those most demanding for water, such as coffee [21, 40]. Soil pore diameter and distribution interfere with drainage ratios, available water content, ion adsorption, root growth, aeration and temperature, acting directly on physical-water phenomena, being an indicator of soil quality [41, 42, 43].
Since soil mineral composition influences pore shape, length and connectivity, soils of oxide mineralogy, such as the very weathered Cerrado Latosols, tend to have a very strong, well-connected microgranular structure with large pore formation. There is formation of thinner and elongated pores [2, 27, 28, 43, 44, 45], which has implications on the water content available to plants.
When used in some production process such as food, fiber or energy, some structural change must occur, modifying the distribution and connection of their pore networks and, consequently, promoting changes in the soil air-water dynamics. In this sense, conservation agriculture [13] has as its principle the physical and chemical improvements of the root environment, by reducing soil tillage and maintaining living or dead surface cover. Thus, it minimizes the compressive and erosive processes, in addition to the oxidation of organic material, promoting the vertical growth of the root system of crops.
With these simple conservationist measures, coupled with the chemical corrections of acidic Latosols, improvements in the physical environment are expected, favored by the good development of the coffee roots, particularly by the reduction of restrictive impediments to the vertical growth of its roots and access to stored water [6, 7, 8, 29] (Figure 9).
Pore distribution of (A) gibbsitic Acrustox and (B) kaolinitic Haplustox, both with the multi-practice conservation management system for coffee cultivation at 0.20–0.34, 0.80–0.94 and 1.50–1.64 m depth. The pore diameter was extract of soil water retention curve by double van Genuchten model. Pore size <0.01 μm corresponds to >3500 kPa by WP4-T psychrometer [
Thus, the conservationist soil management system described by Serafim et al. [10] promoted changes in water retention in very weathered Latosols. According to Carducci et al. [2], the system was able to alter pore scaling such that it increased in the layer of 0–0.20-0.34 m the volume of large macropores (>147 μm) in kaolinitic Latosol and increased the intermediate diameters (73–2.9 μm), which are pores responsible for the gradual release of water to plants [43, 46]. There was also no limitation to aeration in soils (>147 μm: ≈ 15%), because the values were within the acceptable range for gas exchange maintenance (Figure 9).
According to Carducci et al. [2, 47, 48], genetically weathered Latosols present a large amount of interconnected structural pores, which facilitate drainage. Textural pores (including cryptopores) are responsible for water retention of high energy [2, 43, 46, 49] However, because it was submitted to the conservationist management system, there was a small increase in the intermediate pores when compared to the greater depth evaluated in both soils, especially the one with gibbsite.
There is higher water retention in the cryptopores of gibbsitic Acrustox (pores with diameter < 0.01 μm) due to the high energy (3500 kPa), which makes this water unavailable to the roots of coffee trees [48, 49] (Figure 9).
The authors mentioned in the previous paragraph point out that deep preparation and maintenance of Brachiaria sp. should be considered as the main factors of this management system. The additional surface applied gypsum (7 kg m−1), act as the supporting factor in the structure of the soils. Carducci et al. [6], when evaluating the same soils in 3D images obtained by X-ray computed tomography, verified that kaolinitic Latosols presented high spatial variability of the soil structure. These pores resulted from the rapid and well-branched growth of the coffee root system [7, 8]. This is extremely relevant information given that the interactions between soil and root have been considered as a key element for the second green revolution aimed at maximizing production [50].
The water content in the soil profile is one of the main factors of growth and productive vigor of coffee, mainly because it is predominantly implanted in a dry land system. In this sense, the knowledge of soil water dynamics in the root zone in production areas is strategic because it predicts the success of agricultural activity. Management strategies can contribute to the efficient use of stored soil water from rainfall and enable positive responses to the crop.
In order to reduce the effects of water deficit, a plastic film (double-sided, black and white) was used as mulching covering the coffee growing line. Such management provided greater soil water storage up to 0.60 m in an Argisol (Ultisol), with soil moisture above 30% in the dry season, from May to September (Figure 10). In the topsoil, the soil moisture also remained higher, especially in warmer seasons, such as in January. These results coincide with the highest growth in stem height and diameter over the first year of coffee development [51, 52], showing that mulching may be an important alternative for keeping water in the root zone at the most critical time for crop development.
Continuous variation of soil moisture in 2014 in the 0–0.60 m layer of Argisol as a function of conventional management (TES) and plastic cover (MM) in the first year of coffee cultivation. Source: Adapted from Barbosa [
In a Cerrado Latosol cultivated with coffee under a conservation system [10], soil moisture was monitored daily during 2010 by means of a capacitance multi-sensor probe to a depth of 1.0 m [53, 54]. Throughout the evaluated period, the lowest moisture values were observed in the 0.50 to 0.75 m layer, indicating that the coffee tree extracted the largest amount of water at this depth (Figure 11), coinciding with significant presence of coffee roots [7] (Figure 4). In addition, in the months corresponding to the dry season in the region (June to August), it was observed low humidity values in the depth of 1.00 m, and thus deep water absorption, which may have contributed to reduce the water stress suffered by the plant. In this sense, the groove opening and limestone incorporation at 0.60 m associated with the application of additional gypsum may be important for the attenuation of water deficit.
Continuous variation of soil moisture (% by volume) in the planting line (sensor positioned 0.15 m from the coffee tree trunk) as a function of depth (0–1.00 m) and time (March/2010 to December/2010) in a very clayey gibbsitic-oxidic dystrophic red Latosol with coffee during the 2nd year under management system described in Serafim et al. [
An alternative for soil moisture monitoring is the use of remote sensors, given their repeatability characteristics, access to large areas and easy handling. However, it should be taken into account that coffee is a perennial crop with high root system activity at depth, and the use of remote sensor data to directly measure soil moisture is limited to a few centimeters below the surface (±5 cm) [55], not covering the entire area of water extraction by the roots [56]. Santos et al. [57] used the vegetation index EVI-2 to monitor the vegetative vigor of the coffee tree and to correlate it with moisture data at different depths. The authors concluded that it is possible to estimate the water content in the root zone using EVI-2, and that the humidity at a depth of 0.60 m is the one that most reflects the water situation of the plant.
To detail the use of additional gypsum practice, water use by the coffee tree in the soil profile was estimated at different time intervals in 2010 (Figure 12). The coffee tree consumed water to a depth of 0.60 m in both evaluations performed and for all managements, which corroborates the lower moisture values in this layer (Figure 11), confirming the importance of deep tillage and soil correction at 0.60 m. The highest water consumption was observed for treatment G-7, followed by G-28 and lastly for CV-0. The use of additional gypsum allowed the development of thin roots in treatments G-7 and G-28 when compared with CV-0 [11], which may be due to the high levels of exchangeable Ca2+, Mg2+ and K+ in the soil solution, which remained at adequate values to a depth of 0.85 m in the management with additional gypsum application [58].
Water use in layers up to 1.00 m depth during the dry season (May 2010) and in the summer (November 2010) for coffee trees installed in October/2008 due to management with deep soil preparation and limestone incorporation at 0.60 m depth, differing by presenting Brachiaria between the rows and additional application of 7 Mg ha−1 of gypsum (G-7) or 28 Mg ha−1 of gypsum (G-28), and without application of additional gypsum and uncovered line (CV-0). Source: Ivan Célio Andrade Ribeiro.
Water use at a depth of 1.0 m was observed only in the G-7 treatment in November 2010, where the plant consumed about 6% of the stored water. At that time, the coffee tree was 2 years old, showing potential for deep water extraction. Moreover, even in the rainy season there was drought of more than 20 days [29, 53], associated with lower rainfall in the region this year compared to the historical average [59], implying less soil water storage. However, the high soil moisture at a depth of 1.00 m - above the critical moisture content for reducing maximum coffee perspiration in all managements [29] - indicates that this layer is an important water reservoir that can be accessed by plants during the driest or summer periods, reinforcing the importance of deepening the root system through management [29, 59].
Although management with additional gypsum (G-7 and G-28) provided higher water consumption compared to CV-0, it was not possible to differentiate its effects on water stress suffered by plants, evaluated by leaf water potential (ψf) in January, April, and August 2010 (Figure 13). It is noteworthy that in CV-0, although no additional gypsum was applied, liming was performed on the surface and in the planting furrow to a depth of 0.60 m, which favored the deepening of the root system [7].
Water stress assessed by leaf water potential (Ψf) at three times of the year (January 5; January 18 and August 20, 2010), and plant growth at height assessed continuously each month (January 5, 2010 to June 18, 2011) for coffee planted in October 2008 due to management with deep soil preparation and limestone incorporation, differing for presenting Brachiaria between the rows and additional application of 7 Mg ha−1 of gypsum (G-7) or 28 Mg ha−1 of gypsum (G-28), without application of additional gypsum and uncovered gypsum (CV-0). Source: From authors.
The highest water stress was observed in August (Figure 13), coinciding with the peak of the dry season in the region and the lowest soil water content [29, 59]. However, all observed ψf values were below the critical range of water stress that leads to a reduction in coffee crop production, which is between −1.8 and −2.5 MPa [60, 61, 62].
Regarding plant growth, lower plant height values were observed in the G-7 and G-28 managements when compared with CV-0 (Figure 13), which may be explained by competition for root-shoot photoassimilates [63], since the coffee tree showed denser and deeper root systems for G-7 and G-28 [11]. In addition, the evaluations were carried out shortly after planting and, considering that the main morphological and physiological characteristics of the coffee root system complete its development at 5 years of age [1], it is expected that the investments made in liming, application additional gypsum and fertilization result in greater root development in the G-7 and G-28 managements in subsequent years [21].
Despite the lower initial plant growth, the adoption of the conservation management system provided maintenance of the water state of plants during the dry and summer season (Figure 13), resulting in statistically equal yields between CV-0, G-7 and G-28 management system at the first harvest in 2011 [29], highlighting the importance of deep tillage and soil correction. However, in 2012, higher yields were obtained in the managements G-7 and G-28. On average, production was 52.8 bags ha−1 in CV-0 (1 bag = 60 kg of coffee grains), 54.5 bags ha−1 in G-7 and 58.0 bags ha−1 in G-28 [59]. Coffee plants take 2 years to complete their phenological cycle [64]. Thus, soil moisture in 2010 influenced production in 2011 and 2012, demonstrating the positive effect of investments in additional gypsum associated with the maintenance of Brachiaria in the G-7 and G-28 treatments, which provided higher water consumption by the plant in 2010 (Figure 12).
The trend of higher production for management with additional gypsum was confirmed in the 2013 crop, in which 63.0 bags ha−1 was produced in CV-0; 75.5 bags ha−1 in G-7, and 71.1 bags ha−1 in G-28 (data obtained through personal communication with consultants in the area). However, in the 2014 harvest, only the G-28 treatment presented higher yield (87.2 bags ha−1) when compared with CV-0 (85.6 bags ha−1). Management G-7 presented the lowest yield (57.5 bags ha−1). However, when evaluating the general average of the first four seasons, it is observed that there is little difference between the evaluated managements, in which in CV-0 were harvested 63.6 bags ha−1, 60.5 bags ha−1 in G-7 and 68.6 bags ha−1 in G-28.
There have been strong droughts and short-time droughts in rainy season in the main coffee producing regions of Brazil. Although most of the soils used are deep and capable of storing a large volume of water, these soils have a small effective depth for the development of the root system due to severe chemical limitations, therefore causing a yield gap.
Brazilian researchers have studied ways to overcome this problem, such as selecting drought tolerant plants. However, a strategy that has attracted the attention of farmers is the adoption of soil management systems that provide the best development of the coffee root system, with chemical and physical adequacy of soils. Deep tillage, maintenance of intercropped Brachiaria in the coffee plant inter-row and additional gypsum play important roles in this management system. This is relevant information given that the interactions between soil and root have been considered as key elements for the maximization of crop production. Therefore, the set of practices previously mentioned in this chapter has alleviated the soil limitations caused by droughts, root growth and, consequently, the development of productive coffee trees.
Stroke is the world’s second leading cause of death and the third leading cause of disability [1]. Stroke survivors may experience a variety of disabilities that require temporary or long-term assistance. It has a major impact on the patient, their family, the economy of the country, and the world economy [2]. The burden of stroke-related damage is expected to rise in the following decades as the population ages. Even though the death rate from stroke has reduced, the incidence of stroke has not, increasing the number of stroke survivors [3].
Even if people with this condition survive the acute period of their illness, they may have long-term physical and psychological consequences. After the first stroke, the quality of life and health are significantly reduced due to post-stroke impairment [4]. It is still difficult to regain arm and hand function after a stroke, despite stroke rehabilitation methods showing some promise. Due to the increase in the incidence of strokes in 2030 and inadequate facilities offering reperfusion treatments within the small therapeutic window, novel approaches to promote spontaneous brain plasticity are needed [5]. Post-lesional brain plasticity after stroke may be helpful or “adaptive,” or harmful or “maladaptive,” which hinders neurological rehabilitation [6].
Individuals may have considerable dysfunction due to cognitive impairment after a stroke. Memory loss, attention problems, executive and behaviour issues are the most common symptoms seen. After conducting a nationwide epidemiological cohort study on the population and prevalence of chronic brain damage, researchers found that memory impairment (90%), attention disturbance (82%), and executive function impairments were the most frequent cognitive symptoms (75%). Injury mechanisms, demographics, and social variables all impact the intensity and range of cognitive symptoms. Research suggests that 42–92% of patients in the acute phase have attention deficit disorder, and 24–51% have symptoms after leaving acute care. According to recent research, 23–55% of stroke survivors experience memory problems within 3 months, while 11–31% experience memory impairment a year after their stroke. This percentage is comparable in the traumatic brain injury (TBI) group (25%). When people suffer from Unilateral Spatial Neglect (USN) [7], they have trouble orienting themselves or responding or reporting stimuli that emerge on the side opposite the lesion. Stroke patients are more likely than the average population to develop USN. As a result of these cognitive difficulties, rehabilitation efforts are severely hampered, as is returning to work. Cognitive rehabilitation is primarily concerned with making positive changes in a person’s day-to-day life. Instead, cognitive rehabilitation relies on learning compensatory techniques and strategies that have an impact on cognitive function [8]. Several systematic evaluations have looked at how well people recover cognitively after a stroke or traumatic brain injury [9].
In addition to invasive treatments, there has been an increase in interest in examining the influence of non-invasive cortical stimulation on the rehabilitation process [3]. Neuromodulatory non-invasive brain stimulation (NIBS) approaches are being tested to improve motor function following a stroke. Neuromodulation aims to improve adaptively or reduce maladaptive post-stroke reorganisation processes [10].
The idea behind NIBS came from Faraday’s law of induction when, in the 1980s, some researchers stimulated specific areas of the brain using a pulsed magnetic field and noticed changes in the neuronal firing and impulse conduction. Barker et al. demonstrated the first example of transcranial magnetic stimulation (TMS) [11].
Prior to that, electroconvulsive therapy (ECT) to treat severe depression had already been in use since the 1940s. Further studies led to the knowledge that TMS can change the balance between excitation and inhibition leading to speculation that it might be useful in treating conditions such as Parkinson’s disease. However, it was not until the 1990s that specific stimulators were developed that could deliver repetitive impulses to the brain. This lead to the development of a technique called transcranial direct-current stimulation (tDCS) [12, 13].
Transcranial magnetic stimulation (TMS) and transcranial direct-current stimulation (tDCS) have been studied for their effects on motor, sensory, and cognitive skills in stroke patients [3].
TMS can change function and enhance or reduce activity in cortical areas depending on stimulation frequency, duration, coil form, and magnetic field strength. The effects of repeated transcranial magnetic stimulation (rTMS) on cortical excitability can linger up to 2 hours after the stimulation cycle has ended. From minutes to 1 to 2 hours, tDCS can increase or decrease excitability in the stimulated region. Unlike TMS, tDCS appears to modify the activation of sodium- and calcium-dependent channels, as well as NMDA receptor function, causing LTP and LTD-like alterations (Figure 1) [15, 16].
Examples of commercial (A) transcranial direct-current stimulation and (B) transcranial magnetic stimulation equipment, (C, D) coil/electrode montage over the motor cortex, and (D, E) maps of electrical fields generated [
Cortical plasticity refers to the brain’s capacity to change how it functions as a consequence of new learning. In other words “plasticity” refers to any changes in brain organisation as a result of repeated exposure to a stimulus. The term “synaptic plasticity” refers to the ability of synapses to change their strength over time. A single synapse houses all of the plasticity’s manifestations. Both short-term synaptic plasticity and long-term synaptic plasticity have been documented, indicating that synaptic transmission may be boosted or decreased in different time periods [17]. A mechanism known as LTP has been extensively explored when it comes to learning and memory. However, brain damage has been linked to plasticity. That is all it says about the processes at work; it does not explain how the brain may modify its functional and structural structure (both histologically and anthropologically) in the wake of injury and make better use of what is left. The excitability of neuronal networks close and far from the affected region is altered by a stroke. There is less or greater positive plasticity in people who do not fully heal from their injuries. Activity-dependent rebuilding and synaptic strengthening are two pathways for plasticity. Brain-derived nerve factor (BDNF) increases glutamate release and synaptic activity over time. According to animal studies, after a stroke, there is a short window of neuroplasticity during which the most significant advances in recovery may be made. Identifying the processes involved in post-stroke healing and optimising their promotion in each person is the problem.
Another problem is that opposite effects occur at the same time. Tonic inhibition through GABA overexpression is seen in the acute phase of the peri-infarct region. Neuroprotective method to prevent excitotoxicity as well as neuronal death has been hypothesised. Increasing behavioural recovery by blocking GABAergic activity for 1 month might be beneficial. TMS may detect this drop-in activity in the acute period in the patient. The idea was developed over two decades ago, works by delivering a high-intensity electric current through a coil to activate the cortex. For a duration of 0.3–1 ms, a magnetic field of 2–2.5 Tesla is generated by a microsecond-long discharge. A coil is positioned on the scalp to reach the cortex, and the coil creates a magnetic current. An electromagnetic field is formed inside the brain, which dissipates after 3 cm, according to the Faraday principle. This electric field depolarizes neurons in the brain beneath the coil, either directly through an axon hillock or indirectly through depolarizing interneurons [18].
The result of using TMS on the motor cortex is an involuntary contralateral muscular contraction. The magnitude of this motor-evoked potential (MEP) is connected to the number of neurons that have responded to the stimulation, and the latency is a technique to determine that how long it takes for inspiration to generate an MEP. Stroke survivors are on a follow-up of up to 1 year using the following prognostic criteria—the persistence of a motor-evoked potential (MEP) after stimulating the affected hemisphere, which is an excellent predictor of recovery. In contrast, hypo excitability showing lack of response is an indicator of poor functional outcome. However, a condition known as “diaschisis” might result from a unilateral brain injury in which brain regions are affected distant from the lesion site. This term was first used in 1914 by von Monakow. The consequences of a localised brain lesion on physically distant but functionally related regions are discussed [19]. It was initially a clinical notion, but several functional imaging modalities that indicate a change in blood flow to the brain in targeted regions make it possible to display cerebellar diaschisis and transcallosal diaschisis on contralateral cortical regions. A deafferentation mechanism in which the wounded cortex prevents the healthy target structure from being activated is the principle at work (or injured subcortical area). According to Roy and Sherrington’s neurovascular coupling hypothesis, this activation may be either excitatory or inhibitory, affecting the metabolism and local blood flow [20].
The existence of a cortico-cerebellar diaschisis during the acute phase of stroke was related to a worse clinical prognosis after 2 months. Through the corpus callosum, the inter-hemispheric route is highly inhibited. Healthy brains have balanced interhemispheric inhibition, meaning that neither hemisphere is a more significant “inhibitor” than another. Neurovascular coupling theory says that after an infarct on one side, increased cerebral blood flow in the contralateral identical region corresponds to greater activity in that region. This was associated with the most severe impairments, which was surprising. As a result, the contralateral hemisphere continues to impose its inhibitory tone on ischemic hypoactivity, adding to the neurological deficit’s rapid progression. As previously stated, the stroke and the overwhelming imbalanced inhibitory impulse from the better and healthier contralateral hemisphere would cause the ipsilateral ischemic cortex to become doubly impaired. As early as the first week following a stroke, there is evidence of an unbalanced interhemispheric inhibition. Two types of intracortical inhibitory circuits may be studied using TMS paired-pulse protocols—those that are mediated by GABA-A and those by GABA-B.TMS was utilised to discover predictive markers in an investigation of 10 stroke patients who were followed up for 6 months. Recovery is linked to the ipsilateral cortico-spinal pathways of the impacted hemisphere’s comparable integrity in the acute period (as measured by MEP and motor threshold). In both hemispheres, however, recovery is connected to the creation of alternative neural networks as measured with short-term and long-term intracortical inhibition [21].
The contralateral hemisphere appeared to be more significant in major infarcts than in mild infarcts in this small sample. However, extrapolating results to all stroke patients is problematic because of the limited sample and various abnormalities (in the anterior and posterior circulation area, cortical or subcortical). The hemiparetic impairment is worsened in animal tests when the lidocaine is applied to the unaffected hemisphere 4 weeks before the injection, and the middle cerebral artery is closed. This is particularly true if significant lesions are created. As a result, whereas an interhemispheric imbalance is harmful during the acute phase, it is helpful throughout the healing period [22].
Physical medicine and rehabilitation facilities increasingly utilise constraint-induced treatment, which is a direct result of these findings. Forcing a person with cerebral palsy to use one limb while forcing the healthy limb to be inactive is the idea. Two things happen—the stroke-related contralateral main motor cortex region is less active, minimising its inhibitory transcallosal and harmful influence on the ischemic hemisphere, while the ipsilateral hemisphere is overactive. For example, in a meta-analysis of controlled trials of “constraint-induced therapy,” researchers found that the paretic limb improved steadily over time [23]. Still, they could not develop an exact treatment plan because of the wide variety of treatment protocols utilised and the limited number of participants. There was a remarkable correlation between the clinical improvement and the two-fold increase in the excitability characteristics of the damaged hemisphere as evaluated by TMS.
The brain is stimulated by rTMS, also known as repetitive transcranial magnetic stimulation. It includes a continuous sequence of pulses or periodic cycles that alter corticospinal reactivity and processes that might be comparable to LTD or LTP. A further week or two is spent repeating the daily exposure of the exact location for 20 minutes. Pacing has an impact on the outcome. Cortical excitability rises with high-frequency stimulation (i.e., >3 Hz) and decreases with a low-frequency stimulus (i.e., less than 1 Hz) [24].
A conscious patient may quickly and painlessly operate this device. Involuntary contralateral muscle contractions, which may be captured as an MEP, indicate exactly where the coil should be placed over the main motor cortex (M1). A real-time neuronavigation in conjunction with a patient’s own cerebral MRI is indicated as soon as the targeted stimulated region is outside M1. The degree of spatial/temporal resolution through this technique is excellent. However, large and costly equipment is needed, and it cannot be done at the patient’s bedside [25].
Repetitive transcranial magnetic stimulation (rTMS) underwent modifications to create theta-burst stimulation. It uses 50 Hz pulses delivered in three-pulse bursts, separated by a five-pulse gap. Intermittent theta-burst stimulation uses TBS trains lasting 2 s that are repeated every 10 s, increasing excitability. Continuous theta-burst stimulation, on the other hand, uses TBS trains lasting 20–40 seconds to reduce excitability in the cortex (Figure 2).
Blink reflex recordings in a male patient with spinal cord injury before and after rTMS over the vertex [
DCS of the brain in tDCS is more of a neuromodulator than anything else. It is a lot smaller and more portable electrophysiological equipment that may be used at the patient’s bedside. Weak polarising direct current is delivered into the brain by two large electrodes on the head. To modify the threshold of cortical neurons and the intrinsic excitability of the cortex, a direct current source (0.5–2 mA) is used. At the same time, the active electrode is placed over the desired location. Network excitability is polarity-dependent—anodal stimulation raises it, whereas cathodal stimulation lowers it. TDCS is also more convenient to utilise in conjunction with behavioural tasks or during physical and occupational therapy due to its small size (Figures 3 and 4) [29].
(a) TMS, (b) tACS application of alternating current through an electrode [
TMS induced motor evoked potential [
More than 1400 papers have been published thus far on NIBS in humans, with 230 of those papers focusing on stroke-related issues. Mostly, they are concerned with assessing upper-limb motor function, with speech impairments coming in second.
When we look at animal studies there are comparatively little preclinical non-human data on NIBS. The reasons for this are (a) the unavailability of small-sized equipment and (b) ethical issues regarding animal safety. The first animal study for NIBS was conducted in 1990 on rats. Thereafter, a number of studies were conducted on animal models to study the effects of NIBS in Alzheimer’s disease, depression, epilepsy, Huntington’s disease, and stroke. These studies demonstrated positive effects of NIBS on neurorepair, particularly improved motor and cognitive performance. The results of these studies have contributed significantly towards the development of NIBS strategies and protocols [30, 31].
NIBS has been linked to post-stroke aphasia, apraxia, attention, gait abnormalities, and coordination deficits. NIBS stroke treatment techniques were created to improve “adaptive” plasticity and combat “maladaptive” plasticity [22].
After a left hemisphere stroke, aphasia is a frequent side effect. In the past 10 to 15 years, advances in neuroimaging have shown two distinct patterns—Patients with minor left hemisphere lesions are more likely to engage perilesional areas, while individuals with larger ones in the left hemisphere are more likely to recruit homotopic areas mostly in the right. By activating the lesional and contralesional regions of the brain, many non-invasive brain stimulation treatments have been utilised to assist patients to recover from a stroke. Most of these brain stimulation investigations focused on blocking homotopic areas in the right posterior IFG (triangular portion) to effect a supposedly disinhibited right inferior frontal gyrus. In other experiments, the contralesional (right) frontotemporal area or sections of the intact left IFG and perilesional areas have also been stimulated with anodal or excitatory tDCS to increase speech-motor output. Since it provides the cornerstone for motor cortex stimulation research, the interhemispheric disinhibition notion also applies to the language system [32].
Whether NIBS combined with rigorous physical therapy, constraint-induced treatment, robot therapy, or EMG-triggered functional neuromuscular stimulation has any added benefits, remains debatable. NIBS can be used with rTMS or tDCS, but there are no data to support it. This failure remains mysterious. To begin with, it is possible that following the initial process there will be a ceiling effect. The other theory is that the adjuvant treatment has an inhibitory impact rather than a priming effect created by the initial surgery. For this to be adequately understood, it must be viewed in conjunction with the concept of metaplasticity—that is, the ability of activity-dependent synaptic plasticity to be influenced by prior activity at synapses, thereby shifting the criterion for LTP and LTD induction—as well as the concept of homeostatic plasticity, which allows neurons as well as circuits to maintain stability despite synaptic instabilities. Therefore, NIBS may have opposing and invalidating effects on the motor task depending on when it is used (prior, during, or just after neurorehabilitation). Motor learning and NIBS may interact differently depending on when it is administered. More profound knowledge of this interaction is needed to determine whether or not it impacts the synaptic state [33].
There is a larger risk of epilepsy during the acute period of recovery. Therefore early research remains focused on whether or not rTMS could be used to assess the inhibition of the contralateral, unaffected main motor region 3–12 months following stroke. One-time (30-minute) or repeated (20–30-minute) treatments were given to patients with acute ischemic stroke for five working days. Chronic stroke patients were treated with 10 Hz excitatory rTMS, and their brain activity was monitored immediately after the treatment. There were just 10–20 patients in each of the first four investigations. According to research, higher frequencies (3 Hz) were shown to be beneficial in the acute phase, 10 days following the start of the stroke. They found no extra advantage to delivering a greater primary cortex excitation (10 vs. 3 Hz) when contrasting two high-frequency impulses. The treated groups had altered MEP and motor thresholds, as well [18].
These investigations were modest (even in the more extensive trials, 20% of patients were lost to follow-up), although the infarcts were clinically and radiographically homogenous, with subcortical infarcts being the most common. Researchers used a randomised control experiment known as a “crossover study” to assign participants to either receive actual or “sham” stimulation, followed by a 1-week washout period or be randomly assigned to get either one or the other.
Throughout most crossover experiments, patients received one rTMS treatment and one sham session separated by 1 week. The sequence of the trials was chosen at random, and most of the time, the assessment focused on measuring handgrip power or pinching power and velocity. When particularly examined, the rTMS effect had vanished after 30 minutes, indicating that it had no impact on the next session’s outcomes.
Because the device is less costly and simpler to use than rTMS, tDCS offers great potential. tDCS has been found to extend the time it takes for patients to recover from motor impairments when used repeatedly. To combat extremely high levels of interhemispheric inhibition via the contralesional M1 and reverse the ipsilesional hypoexcitability, stimulation paradigms such as cathodal stimulation of the undamaged hemisphere and anodal stimulation of the afflicted hemisphere have been proposed. Repetitive transcranial magnetic stimulation (rTMS) has been used mostly in the chronic phase of illness for repeated tDCS sessions. For example, it was found that compared to sham tDCS, cathodal tDCS of the unaffected hemisphere enhanced hand motor performance, which was assessed by a blinded Jebsen Taylor Hand function test. The effects of cathodal tDCS applied 5 days in a row persisted for at least 2 weeks. Lindenberg et al. investigated tDCS stimulation (cathodal stimulation in the unaffected hemisphere and anodal stimulation in the afflicted hemisphere) in 20 chronic stroke patients who were also receiving physical and occupational therapy (with a follow-up of more than 5 months) [34]. When compared to placebo, real stimulation resulted in a greater improvement in motor function (+21% for Fugl-Meyer and 19% for Wolf Motor Function test scores), and this improvement lasted at least 1 week following the treatment. It was shown that in the group that received actual stimulation, the ipsilesional primary and premotor cortexes were more active during timed movements of the afflicted limb [35].
Before now, most NIBS procedures were built on the interhemispheric competitive concept, which holds that the healthy hemisphere suppresses the injured hemisphere excessively. This model-based strategy is widely employed in recent and continuing clinical studies, despite being typically useless at the collective level. The reliability of this concept has been called into doubt, particularly in seriously damaged individuals, and an alternate model, the vicariation model, has been proposed. According to this model [22] when one of the brain’s hemispheres is impaired, the other makes up for it by performing better and resulting in an adaptive system rather than a maladaptive one.
The bimodal-balance recovery model combines these previously disparate theories, allowing us to get closer to personalised treatment. Assume that a patient is best served by the inter-hemispheric competition or vicariation model. It uses a metric known as “structural reserve” in this situation, which is defined as the integrity of white matter motor pathways. Patients with a strong structural reserve have a maladaptive over-activation of the undamaged hemisphere; patients with poor structural reserve have a compensating over-activation [36]. The fact that patients with extensive brain damage, who are thought to have a limited structural reserve, have inferior results when inhibitory NIBS protocols are administered to their undamaged hemispheres supports this approach, stressing the need to change “one-size-fits-all” NIBS protocols. However, whether clinical and imaging parameters may serve as good substitutes for structural reserve has not been answered. Much research has looked at these factors’ capacity to predict stroke outcome, but the strongest evidence comes from those studies [37]. Using diffusion tensor imaging, the fractional anisotropy for white matter tracts is routinely employed to quantify white matter integrity. Although stroke prognosis may be accurately predicted with a strong predictive biomarker, this is not always the case for responding to certain NIBS paradigms. Prognostic biomarkers could be a good place to start, but they must be verified to show their unique function and relative relevance in affecting the outcome of NIBS after a stroke reaction. According to two recent promising studies, behavioural assessments like the Action Research Arm Test and the Fugl-Meyer score, together with imaging-based measures of white matter integrity, are predictive of responsiveness to NIBS. As a result of such studies, the bimodal-balance recovery model is given support, as are future studies that will validate these selection biomarkers using clinical and imaging initiatives related to the structural reserve [38].
Methodologically, significant/extensive trials with many individuals and variables are required to build a framework for customising the treatment for each patient using NIBS. Machine learning algorithms would be best suited for analysing such vast volumes of complicated data. Because of the strong association between imaging-based biomarkers and clinical manifestations of stroke, potential models for guiding NIBS therapy do not need to be particularly complicated. Instead, strongly correlated steps can be whittled down to factors of a lower dimension that describe a significant amount of variability.
Stroke is a widespread illness that affects people throughout the body. After a stroke, the impact of disrupted networks may be felt far and wide, and the formation of new indirect connections is the fundamental mechanism regulating these effects [39]. Individual stroke recovery is linked to alterations in long-range connections between different brain areas outside of lesions, as well as their regulation throughout time, as studied in resting-state functional MRI in whole-brain. Alterations best describe a single patient in numerous functional networks, which are common in strokes. Since both stroke connectivity and NIBS protocol changes have primarily been examined in the setting of isolated networks, these variables are likely to have contributed to the documented response variability with NIBS. However, this has not been fully explored thus far. It’s hard to assume that a single functional network is being addressed in these patients when administering stimulation because of the impact of NIBS on dispersed networks and the notion of stroke as a dispersed disease. Rs-fMRI whole-brain connectivity is ideal for application in patients since it provides information on the functional connectivity of several brain networks in a single task-free scan. A much more accurate model of spontaneous reorganisation following stroke might be developed using this method, and it could be useful in devising personalised stimulation regimes [10]. Connectivity techniques have a methodological disadvantage in that they depend on a prior determination of relatively arbitrary multiple networks. This issue is solved by reducing the number of dimensions in the brain’s connections. Areas are grouped in a parametric, gradual way based on their connection patterns using the data-driven technique. Reduced dimensionality of whole-brain linkages may offer a fingerprinting of the connectome at the individual level, reflecting a clearer image of stroke spanning several functional domains. When we used this technique to study stroke lesions, we discovered that the degree of rearrangement that occurred in the first week after stroke was linked to the position of the stroke lesions in space for whole-brain neural systems. We believe that constructing whole-brain connection models will help us better understand the long-term consequences of localised lesions [40].
NIBS reaction prediction using electroencephalogram (EEG) connectivity has shown impressive outcomes. Functional integration modifications to prognostic models of stroke output have added value, so we believe connectivity patterns could be a potential biomarker for NIBS responses in future research. As time goes on, establishing a relationship between a connectome fingerprint and sudden retrieval in several functional domains will be critical and the impact of the connectome fingerprint on clinical reactions to NIBS before stimulation.
A variety of variables may influence response to NIBS, both instantaneous (“state”) as well as phenotypic (“trait”). Both may be evaluated using the features of neural oscillations, which indicate the cortex’s receptivity to stimulus. You cannot know in advance how someone will react to a stimulation procedure. Even in the absence of disease, the same NIBS procedure might have excitation, inhibiting, or no impacts on motor elicited potentials in different people. One strategy is to time the stimulation to coincide with the most excitable brain states to limit this unpredictability. The findings that pre-stimulus alpha oscillations correlate with TMS response variability, that the intensity of sensorimotor mu oscillations (8–12 Hz over central-parietal electrodes) correlates with the magnitude of motor evoked potentials, and that the synchrony of mu oscillations in contralateral M1 is related to greater interhemispheric inhibition, all support the importance of these processes [10]. Current research focuses on NIBS that are “state-dependent.”
Subject-specific and highly heritable characteristics of neuronal oscillations characterise immediate cortical responsiveness to NIBS Alpha band (80 Hz) power, and the temporal variation of α- and β-band oscillations are especially relevant here. These findings support the hypothesis that neuronal oscillation features during rest might reflect a phenotypic trait in addition to transitory situations. Healthy people have reasonably good intra-subject reliability for the response to NIBS, which is also strongly heritable. Recently, EEG research found a correlation between healthy people’s reaction to paired-pulse TMS and alpha band temporal dynamics before intervention on an individual basis. These findings demonstrate that cortical plasticity is purely genetic, indicating that the brain can be controlled in a trait-like manner [41].
The critical condition is an equilibrium between inhibitory and excitatory that is best for processing information in neural networks. Additionally, critical states are connected with long-range temporal connections (LRTCs) in neuronal oscillation amplitude dynamics. Following a stroke, and various other neuropsychiatric illnesses, LRTCs—which connect to cortical excitability—are prone to be disrupted, as they are in both cases. This suggests that patterns of disruption are associated with spontaneous recovery since the network eventually achieves a compensating equilibrium. Clinically approachable approaches such as resting EEG may be used to quantify the trait-like features of neural oscillations [33].
Recent advancements in NIBS technology are expected to aid in the formulation of more personalised treatment plans. Through multi-locus TMS, it will be possible to move beyond single-area stimulation to target specific muscle groups with different functions in post-stroke motor therapy. Because the coil does not need to be repositioned, this method stimulates many locations with excellent temporal accuracy. With improved induced electrical field modelling, it is possible to forecast exactly what changes will be caused by NIBS on some kind of sub-regional level (for instance, in particular areas of the motor homunculus). Finally, non-invasive stimulation techniques such as transcranial focused ultrasound or temporal interference could be used to target deep brain areas that are inaccessible with TMS and tDCS yet critical for dexterity deficiencies and pathological synergies in stroke [42]. They may help progress NIBS translation while accepting the unavoidable variability of stroke pathophysiology and the discovery and validation of useful biomarkers related to NIBS.
Minimal side effects, such as transient headache, neck pain, and transient hearing changes, have been reported with the use of NIBS by researchers. However, most of these results are from studies that involved single burst stimulation and knowledge about potential detrimental side effects of repeated stimulation are minimal [43]. An area that poses ethical questions is making the distinction between enhancement and treatment (Figures 5 and 6).
Patterns of application of transcranial magnetic stimulation [
Maximum safe train duration (seconds) limits [
In view of ongoing efforts to improve the efficacy of TMS as a technique of inducing persistent changes in brain function, assessing the safety of TMS with neuroimaging becomes extremely important. For therapeutic and research purposes, use of TMS the following three requirements must be kept in mind.
Informed consent from the subject or their legal representative
Potential benefits must outweigh the risks
The subjects chosen must not be socially, physically, or economically vulnerable [44]
There are an infinite number of protocol combinations that can be used. However, it is crucial that careful monitoring of motor, sensory, and cognitive functions be done before, during, and after the intervention.
The resulting growing clinical use of NIBS requires careful guidelines both in terms of equipment and training of the medical staff carrying out NIBS.
In the United States (US), the Food and Drug Administration (FDA) has cleared seven devices for therapeutic TMS in patients of treatment-resistant depression, one device for pre-surgical motor and language cortical mapping, and one device for abortive treatment of migraines. To date, there are no FDA-approved applications of tCS. The FDA takes into account details like coil positioning, output waveform, strength and distribution of the magnetic field safety features of the device.
Currently, there are no requirements or certifications governing a provider’s proficiency regarding NIBS before using it. However, it is recommended that all physicians using it undergo training. There are limited programs being offered in some institutes [46].
Both rTMS and tDCS have been shown to have long-term benefits, with improvements ranging from 10 to 20% based on the literature’s upper limb motor performance assessments. In the acute period (6–29 days) high-frequency stimulation of the ipsilaterally affected hemisphere is more effective than low-frequency stimulation of the non-affected, undamaged hemisphere [47].
Stroke-specific adverse effects include moderate headache (2.4%), anxiousness (0.3%), neuro-cardiogenic syncope (0.6%), worsening of pre-existing sleeplessness (0.3%), and local pain at the stimulation site [6]. Adverse events in children and young adults are very similar to those seen in adults—headaches (11.5%), scalp irritation (2.5%), twitching (1.2%), mood swings (1.2%), tiredness (0.9%), tinnitus (0.6%), tingling (11.5%), itchiness (5.8%), redness (4.7%), and scalp irritation (3.1%) have been reported after tDCS protocols [7].
Seizures are the only possible major side effect [48]. Other than stroke peculiarities, certain relevant aspects have been identified from the overall NIBS experience. Even while 0–3.6% of individuals with epilepsy have an epileptic seizure while receiving NIBS, this does not alter the course of their condition. If the antiepileptic plasma level is insufficient, there is a higher incidence of interictal epileptiform discharges (>10/min) and complex temporal seizures are also common (>4/month). Stimulation is followed by a current epileptic seizure (48 hours), and the risk is increased if the epileptogenic region is specifically excited. If there is a family history of epileptic seizures, if the patients receive regular epileptogenic psychotropes, if there is chronic alcohol or opiate abuse, an underpinning neurological disease, severe heart disease, sleep problems, a younger child, or female sex, there is a higher risk of inducing an epileptic seizure in non-epileptic patients [48].
In the literature, the extent of improvement from upper limb motor functional evaluation using rTMS or tDCS is reported to be around 10% and 20%. Clinical trials’ results do not match those of meta-analyses, but variability in stroke history, personal susceptibility, outcomes, and a lack of basic understanding of where to administer adjuvant medicines-and the impact of concurrent medications confuse interpretation. As the illness progresses, pharmacological, electrophysiological, or physical adjuvant treatment might potentially improve patient care. Considering the disease’s severity, this should favour a patient-tailored strategy more than other techniques.
These Terms and Conditions outline the rules and regulations pertaining to the use of IntechOpen’s website www.intechopen.com and all the subdomains owned by IntechOpen located at 5 Princes Gate Court, London, SW7 2QJ, United Kingdom.
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\\n\\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
\\n\\n“Client”, “Customer”, “You” and “Your” refers to you, the person accessing this website and accepting the Company’s Terms and Conditions;
\\n\\n“The Company”, “Ourselves”, “We”, “Our” and “Us”, refers to our Company, IntechOpen;
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\\n\\nUnless otherwise stated, IntechOpen and/or its licensors own the intellectual property rights for all materials on www.intechopen.com. All intellectual property rights are reserved. You may view, download, share, link and print pages from www.intechopen.com for your own personal use, subject to the restrictions set out in these Terms and Conditions.
\\n\\nWe employ the use of cookies. By using the IntechOpen website you consent to the use of cookies in accordance with IntechOpen’s Privacy Policy. Most modern day interactive websites use cookies to enable the retrieval of user details for each visit. On our site, cookies are predominantly used to enable functionality and ease of use for those visiting the site.
\\n\\nIn no circumstances shall IntechOpen or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption) arising out of the use, or inability to use, the materials on IntechOpen's websites, even if IntechOpen or an IntechOpen authorized representative has been notified orally or in writing of the possibility of such damage. Some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages; consequently, these limitations may not apply to you.
\\n\\nIntechopen.com website content and services are provided on an "AS IS" and an "AS AVAILABLE" basis. Material appearing on www.intechopen.com could include minor technical, typographical, or photographic errors. IntechOpen may make changes to any material contained on its website at any time without notice.
\\n\\nIntechOpen has no formal affiliation to any external sites that link to www.intechopen.com, unless otherwise specifically stated. As such, it is not responsible for content that appears on any such sites. The inclusion of any link to IntechOpen does not imply endorsement by IntechOpen. Use of any such linked website is done solely at the user's own discretion.
\\n\\nWe reserve the right of ownership over our entire website www.intechopen.com, and all contents. By using our services, you agree to remove all links to our website immediately upon request. We also reserve the right to amend these Terms and Conditions and our linking policy at any time. By continuing to link to our website, you agree to be bound to, and abide by, these linking Terms and Conditions.
\\n\\nIf you find any link on our website, or any linked website, objectionable for any reason, please Contact Us. We will consider all requests to remove links but will have no obligation to do so.
\\n\\nWithout prior approval and express written permission, you may not create frames around our web pages or use other techniques that alter in any way the visual presentation or appearance of our website.
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\\n\\nCroatian version of Terms and Conditions available here
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\n\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
\n\n“Client”, “Customer”, “You” and “Your” refers to you, the person accessing this website and accepting the Company’s Terms and Conditions;
\n\n“The Company”, “Ourselves”, “We”, “Our” and “Us”, refers to our Company, IntechOpen;
\n\n“Party”, “Parties”, or “Us”, refers to both the Client and ourselves, or either the Client or ourselves.
\n\nAll Terms refer to the offer, acceptance, and consideration of payment necessary to provide assistance to the Client in the most appropriate manner, whether by formal meetings of a fixed duration, or by any other agreed means, for the express purpose of meeting the Client’s needs in respect of provision of the Company’s stated services/products, and in accordance with, and subject to, the prevailing laws of the United Kingdom.
\n\nAny use of the above terminology, or other words in the singular, plural, capitalization and/or he/she or they, are taken as interchangeable.
\n\nUnless otherwise stated, IntechOpen and/or its licensors own the intellectual property rights for all materials on www.intechopen.com. All intellectual property rights are reserved. You may view, download, share, link and print pages from www.intechopen.com for your own personal use, subject to the restrictions set out in these Terms and Conditions.
\n\nWe employ the use of cookies. By using the IntechOpen website you consent to the use of cookies in accordance with IntechOpen’s Privacy Policy. Most modern day interactive websites use cookies to enable the retrieval of user details for each visit. On our site, cookies are predominantly used to enable functionality and ease of use for those visiting the site.
\n\nIn no circumstances shall IntechOpen or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption) arising out of the use, or inability to use, the materials on IntechOpen's websites, even if IntechOpen or an IntechOpen authorized representative has been notified orally or in writing of the possibility of such damage. Some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages; consequently, these limitations may not apply to you.
\n\nIntechopen.com website content and services are provided on an "AS IS" and an "AS AVAILABLE" basis. Material appearing on www.intechopen.com could include minor technical, typographical, or photographic errors. IntechOpen may make changes to any material contained on its website at any time without notice.
\n\nIntechOpen has no formal affiliation to any external sites that link to www.intechopen.com, unless otherwise specifically stated. As such, it is not responsible for content that appears on any such sites. The inclusion of any link to IntechOpen does not imply endorsement by IntechOpen. Use of any such linked website is done solely at the user's own discretion.
\n\nWe reserve the right of ownership over our entire website www.intechopen.com, and all contents. By using our services, you agree to remove all links to our website immediately upon request. We also reserve the right to amend these Terms and Conditions and our linking policy at any time. By continuing to link to our website, you agree to be bound to, and abide by, these linking Terms and Conditions.
\n\nIf you find any link on our website, or any linked website, objectionable for any reason, please Contact Us. We will consider all requests to remove links but will have no obligation to do so.
\n\nWithout prior approval and express written permission, you may not create frames around our web pages or use other techniques that alter in any way the visual presentation or appearance of our website.
\n\nIntechOpen may revise its Terms of Service for its website at any time without notice. By using this website, you are agreeing to be bound by the current version of all Terms at the time of use.
\n\nThese Terms and Conditions are governed by and construed in accordance with the laws of the United Kingdom and you irrevocably submit to the exclusive jurisdiction of the courts in London, United Kingdom.
\n\nCroatian version of Terms and Conditions available here
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Cabanelas"}]},{id:"53973",doi:"10.5772/66927",title:"Phenolic Compounds in Water: Sources, Reactivity, Toxicity and Treatment Methods",slug:"phenolic-compounds-in-water-sources-reactivity-toxicity-and-treatment-methods",totalDownloads:7324,totalCrossrefCites:77,totalDimensionsCites:170,abstract:"Phenolic compounds exist in water bodies due to the discharge of polluted wastewater from industrial, agricultural and domestic activities into water bodies. They also occur as a result of natural phenomena. These compounds are known to be toxic and inflict both severe and long‐lasting effects on both humans and animals. They act as carcinogens and cause damage to the red blood cells and the liver, even at low concentrations. Interaction of these compounds with microorganisms, inorganic and other organic compounds in water can produce substituted compounds or other moieties, which may be as toxic as the original phenolic compounds. This chapter dwells on the sources and reactivity of phenolic compounds in water, their toxic effects on humans, and methods of their removal from water. Specific emphasis is placed on the techniques of their removal from water with attention on both conventional and advanced methods. Among these methods are ozonation, adsorption, extraction, photocatalytic degradation, biological, electro‐Fenton, adsorption and ion exchange and membrane‐based separation.",book:{id:"6029",slug:"phenolic-compounds-natural-sources-importance-and-applications",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Natural Sources, Importance and Applications"},signatures:"William W. Anku, Messai A. Mamo and Penny P. 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In addition, the postharvest conditions may modify several phytochemical substances. Phenolic compounds are referred to as phytochemicals found in a large number of foods and beverages. The relative high diversity of these molecules produced by plants must be taken into account when methods of preparation are employed to obtain industrial or homemade products. Phenolic compounds comprise one (phenolic acids) or more (polyphenols) aromatic rings with attached hydroxyl groups in their structures. Their antioxidant capacities are related to these hydroxyl groups and phenolic rings. Despite the antioxidant activity, they have many other beneficial effects on human health. However, before attributing health benefits to these compounds, absorption, distribution, and metabolism of each phenolic compound in the body are important points that should be considered.",book:{id:"5609",slug:"phenolic-compounds-biological-activity",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Biological Activity"},signatures:"Igor Otavio Minatel, Cristine Vanz Borges, Maria Izabela Ferreira,\nHector Alonzo Gomez Gomez, Chung-Yen Oliver Chen and\nGiuseppina Pace Pereira Lima",authors:[{id:"146379",title:"Dr.",name:"Giuseppina",middleName:null,surname:"Lima",slug:"giuseppina-lima",fullName:"Giuseppina Lima"},{id:"194002",title:"MSc.",name:"Cristine",middleName:null,surname:"Vanz Borges",slug:"cristine-vanz-borges",fullName:"Cristine Vanz Borges"},{id:"194003",title:"Prof.",name:"Igor Otavio",middleName:null,surname:"Minatel",slug:"igor-otavio-minatel",fullName:"Igor Otavio Minatel"},{id:"194004",title:"Dr.",name:"Maria Izabela",middleName:null,surname:"Ferreira",slug:"maria-izabela-ferreira",fullName:"Maria Izabela Ferreira"},{id:"194005",title:"Prof.",name:"Hector",middleName:null,surname:"Gomez-Gomez",slug:"hector-gomez-gomez",fullName:"Hector Gomez-Gomez"},{id:"194006",title:"Prof.",name:"Chung-Yen Oliver",middleName:null,surname:"Chen",slug:"chung-yen-oliver-chen",fullName:"Chung-Yen Oliver Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"55500",title:"Interpretation of Mass Spectra",slug:"interpretation-of-mass-spectra",totalDownloads:12503,totalCrossrefCites:12,totalDimensionsCites:25,abstract:"The chapter includes an introduction to the main ionisation techniques in mass spectrometry and the way the resulting fragments can be analysed. First, the fundamental notions of mass spectrometry are explained, so that the reader can easily cover this chapter (graphs, main pick, molecular ion, illogical pick, nitrogen rule, etc.). Isotopic percentage and nominal mass calculation are also explained along with fragmentation mechanism. A paragraph emphasises the ionisation energy issues, the basics of ionisation voltage, the developing potential and the energy balance. A frame time of the main theoretical milestones in both theory and experimental mass spectrometry is highlighted here. In the second part of the chapter, the molecular fragmentation for alkanes, iso-alkanes, cycloalkanes, halogen, alcohols, phenols, ethers, carbonyl compounds, carboxylic acids and functional derivatives, nitrogen compounds (amines, nitro compounds), sulphur compounds, heterocycles and biomolecules (amino acids, steroids, triglycerides) is explained. Fragmentation schemes are followed by the simplified spectra, which help the understanding of such complex phenomena. At the end of the chapter, acquisition of mass spectrum is discussed. The chapter presented here is an introduction to mass spectrometry, which, we think, helps the understanding of the mechanism of fragmentation corroborating spectral data and molecular structures.",book:{id:"5735",slug:"mass-spectrometry",title:"Mass Spectrometry",fullTitle:"Mass Spectrometry"},signatures:"Teodor Octavian Nicolescu",authors:[{id:"196775",title:"Dr.",name:"Teodor Octavian",middleName:"Octavian",surname:"Nicolescu",slug:"teodor-octavian-nicolescu",fullName:"Teodor Octavian Nicolescu"}]},{id:"57909",title:"Validation of Analytical Methods",slug:"validation-of-analytical-methods",totalDownloads:6989,totalCrossrefCites:13,totalDimensionsCites:21,abstract:"Method validation is a key element in the establishment of reference methods and within the assessment of a laboratory’s competence in generating dependable analytical records. Validation has been placed within the context of the procedure, generating chemical data. Analytical method validation, thinking about the maximum relevant processes for checking the best parameters of analytical methods, using numerous relevant overall performance indicators inclusive of selectivity, specificity, accuracy, precision, linearity, range, limit of detection (LOD), limit of quantification (LOQ), ruggedness, and robustness are severely discussed in an effort to prevent their misguided utilization and ensure scientific correctness and consistency among publications.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Tentu Nageswara Rao",authors:[{id:"220824",title:"Dr.",name:"Tentu",middleName:null,surname:"Nageswara Rao",slug:"tentu-nageswara-rao",fullName:"Tentu Nageswara Rao"}]},{id:"55440",title:"Solubility Products and Solubility Concepts",slug:"solubility-products-and-solubility-concepts",totalDownloads:3090,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"The chapter refers to a general concept of solubility product Ksp of sparingly soluble hydroxides and different salts and calculation of solubility of some hydroxides, oxides, and different salts in aqueous media. A (criticized) conventional approach, based on stoichiometry of a reaction notation and the solubility product of a precipitate, is compared with the unconventional/correct approach based on charge and concentration balances and a detailed physicochemical knowledge on the system considered, and calculations realized according to generalized approach to electrolytic systems (GATES) principles. An indisputable advantage of the latter approach is proved in simulation of static or dynamic, two-phase nonredox or redox systems.",book:{id:"5891",slug:"descriptive-inorganic-chemistry-researches-of-metal-compounds",title:"Descriptive Inorganic Chemistry Researches of Metal Compounds",fullTitle:"Descriptive Inorganic Chemistry Researches of Metal Compounds"},signatures:"Anna Maria Michałowska-Kaczmarczyk, Aneta Spórna-Kucab and\nTadeusz Michałowski",authors:[{id:"35273",title:"Prof.",name:"Tadeusz",middleName:null,surname:"Michalowski",slug:"tadeusz-michalowski",fullName:"Tadeusz Michalowski"},{id:"203867",title:"Dr.",name:"Anna Maria",middleName:null,surname:"Michałowska-Kaczmarczyk",slug:"anna-maria-michalowska-kaczmarczyk",fullName:"Anna Maria Michałowska-Kaczmarczyk"},{id:"203868",title:"Dr.",name:"Aneta",middleName:null,surname:"Spórna-Kucab",slug:"aneta-sporna-kucab",fullName:"Aneta Spórna-Kucab"}]},{id:"62736",title:"Radioisotope: Applications, Effects, and Occupational Protection",slug:"radioisotope-applications-effects-and-occupational-protection",totalDownloads:4543,totalCrossrefCites:10,totalDimensionsCites:17,abstract:"This chapter presents a brief introduction to radioisotopes, sources and types of radiation, applications, effects, and occupational protection. The natural and artificial sources of radiations are discussed with special reference to natural radioactive decay series and artificial radioisotopes. Applications have played significant role in improving the quality of human life. The application of radioisotopes in tracing, radiography, food preservation and sterilization, eradication of insects and pests, medical diagnosis and therapy, and new variety of crops in agricultural field is briefly described. Radiation interacts with matter to produce excitation and ionization of an atom or molecule; as a result physical and biological effects are produced. These effects and mechanisms are discussed. The dosimetric quantities used in radiological protection are described. Radiological protections and the control of occupational and medical exposures are briefly described.",book:{id:"5903",slug:"principles-and-applications-in-nuclear-engineering-radiation-effects-thermal-hydraulics-radionuclide-migration-in-the-environment",title:"Principles and Applications in Nuclear Engineering",fullTitle:"Principles and Applications in Nuclear Engineering - Radiation Effects, Thermal Hydraulics, Radionuclide Migration in the Environment"},signatures:"Sannappa Jadiyappa",authors:[{id:"239626",title:"Dr.",name:null,middleName:null,surname:"Sannappa J.",slug:"sannappa-j.",fullName:"Sannappa J."}]},{id:"58596",title:"Linearity of Calibration Curves for Analytical Methods: A Review of Criteria for Assessment of Method Reliability",slug:"linearity-of-calibration-curves-for-analytical-methods-a-review-of-criteria-for-assessment-of-method",totalDownloads:8095,totalCrossrefCites:19,totalDimensionsCites:44,abstract:"Calibration curve is a regression model used to predict the unknown concentrations of analytes of interest based on the response of the instrument to the known standards. Some statistical analyses are required to choose the best model fitting to the experimental data and also evaluate the linearity and homoscedasticity of the calibration curve. Using an internal standard corrects for the loss of analyte during sample preparation and analysis provided that it is selected appropriately. After the best regression model is selected, the analytical method needs to be validated using quality control (QC) samples prepared and stored in the same temperature as intended for the study samples. Most of the international guidelines require that the parameters, including linearity, specificity, selectivity, accuracy, precision, lower limit of quantification (LLOQ), matrix effect and stability, be assessed during validation. Despite the highly regulated area, some challenges still exist regarding the validation of some analytical methods including methods when no analyte-free matrix is available.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Seyed Mojtaba Moosavi and Sussan Ghassabian",authors:[{id:"216099",title:"Dr.",name:"Sussan",middleName:null,surname:"Ghassabian",slug:"sussan-ghassabian",fullName:"Sussan Ghassabian"},{id:"216101",title:"Mr.",name:"Seyed Mojtaba",middleName:null,surname:"Moosavi",slug:"seyed-mojtaba-moosavi",fullName:"Seyed Mojtaba Moosavi"}]}],onlineFirstChaptersFilter:{topicId:"8",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83005",title:"Catalytic Behavior of Extended π-Conjugation in the Kinetics of Sensitizer-Mediator Interaction",slug:"catalytic-behavior-of-extended-conjugation-in-the-kinetics-of-sensitizer-mediator-interaction",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106511",abstract:"This chapter discusses the catalytic effect of extended π-conjugation on the electron transfer process between ferricyphen-ferrocyanide and ferricypyr-ferrocyanide in an aqueous medium. Ferricyphen and ferricypyr may be feasible options for the sensitizer in dye-sensitized solar cells due to their high reduction potential, stability, capability as an outer-sphere oxidant, and photosensitivity. Meanwhile, ferrocyanide could be used as a mediator in DSSCs instead of iodide to avoid iodate production and achieve a similar reduction potential and stability. This chapter compared the ability of competent putative sensitizers to oxidize the likely mediator in water. In contrast to the 2,2′-dipyridyl chelate, the extended π-conjugation in 1,10-phenanthroline accelerated the redox process by increasing the electron affinity of ferricyphen as compared to ferricypyr. The reactions had the same kinetics but different rate constants, indicating that the ferricyphen-ferrocyanide reaction was several times faster than the ferricypyr-ferrocyanide reaction, revealing and confirming the catalytic influence of extended π-conjugation on the redox process.",book:{id:"11217",title:"Recent Advances in Chemical Kinetics",coverURL:"https://cdn.intechopen.com/books/images_new/11217.jpg"},signatures:"Rozina Khattak"},{id:"83004",title:"Pyridine Heterocycles in the Therapy of Oncological Diseases",slug:"pyridine-heterocycles-in-the-therapy-of-oncological-diseases",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.106406",abstract:"Oncological diseases pose a major challenge for modern medicine. Heterocyclic compounds play a vital role in modern medical and pharmaceutical science as most medicinal substances incorporate them. Nitrogen-containing heterocycles serve as the basis of numerous drugs and, therefore, are deeply involved in the design and synthesis of promising new therapeutic agents. Pyridine or pyrimidine scaffolds, with a number of substituents attached, comprise a large portion of FDA-approved drugs. They are chemically stable in the human body, manifest an affinity for DNA via hydrogen bonding, and present an opportunity for the development of novel anticancer agents. A large number of pyridine-based molecules are synthesized and tested for anticancer activity each year. The present chapter aims to introduce the most current synthetic approaches, published in scientific literature, and would also elaborate on structure-activity relationships described therein.",book:{id:"11562",title:"Chemistry with Pyridine Derivatives",coverURL:"https://cdn.intechopen.com/books/images_new/11562.jpg"},signatures:"Lozan T. Todorov and Irena P. Kostova"},{id:"82969",title:"Utilizing Photocatalysts in Reducing Moisture Absorption in Composites of Natural Fibers",slug:"utilizing-photocatalysts-in-reducing-moisture-absorption-in-composites-of-natural-fibers",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106543",abstract:"Due to growing environmental consciousness and the depletion of oil supplies, numerous efforts have been made to replace synthetic fibers in fiber-reinforced composites with natural fibers (NFr). The low cost and abundance of NFr and its biodegradability and low density have encouraged researchers worldwide to study their potential applications in several industrial sectors. However, NFr has several disadvantages: excessive moisture absorption and subsequent swelling and degradation, low chemical and fire resistance, and insufficient interfacial interactions with polymers. Consequently, there is great interest in modifying the surface of NFr using a variety of methods. This chapter presents an overview of the NFr, its characterization, the problems associated with adding NFr to polymer composites. This literature survey suggests an in-depth review of photocatalysis by utilizing photocatalysts nanoparticle (PHNPs) aimed at increasing the hydrophobicity and interfacial bonding between the NFr and the matrix Using a photo-induced oxidation mechanism to disassemble water molecules, pollutants, and bacteria in a wet environment. Additionally, we reviewed the effects of these PHNPs on the moisture absorption, mechanical characteristics, and dimensional stability of NFr composites. As a result, this review article may make a valuable contribution to researchers interested in coating and treating NFr to further enhance their surface characteristics.",book:{id:"11559",title:"Photocatalysts - New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11559.jpg"},signatures:"Mohammed Mohammed and Rozyanty Rahman"},{id:"82853",title:"Revealing Retention Mechanisms in Liquid Chromatography: QSRR Approach",slug:"revealing-retention-mechanisms-in-liquid-chromatography-qsrr-approach",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.106245",abstract:"One-factor-at-a-time experimentation was used for a long time as gold-standard optimization for liquid chromatographic (LC) method development. This approach has two downsides as it requires a needlessly great number of experimental runs and it is unable to identify possible factor interactions. At the end of the last century, however, this problem could be solved with the introduction of new chemometric strategies. This chapter aims at presenting quantitative structure–retention relationship (QSRR) models with structuring possibilities, from the point of feature selection through various machine learning algorithms that can be used in model building, for internal and external validation of the proposed models. The presented strategies of QSRR model can be a good starting point for analysts to use and adopt them as a good practice for their applications. QSRR models can be used in predicting the retention behavior of compounds, to point out the molecular features governing the retention, and consequently to gain insight into the retention mechanisms. In terms of these applications, special attention was drawn to modified chromatographic systems, characterized by mobile or stationary phase modifications. Although chromatographic methods are applied in a wide variety of fields, the greatest attention has been devoted to the analysis of pharmaceuticals.",book:{id:"11557",title:"Chemometrics - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11557.jpg"},signatures:"Jovana Krmar, Bojana Svrkota, Nevena Đajić, Jevrem Stojanović, Ana Protić and Biljana Otašević"},{id:"82796",title:"A Revisit of the Underlying Fundamentals in the Laser Emission from BODIPYs",slug:"a-revisit-of-the-underlying-fundamentals-in-the-laser-emission-from-bodipys",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.106334",abstract:"This chapter aims to provide a comprehensive assessment of the laser performance of commercially available laser dyes based on the boron-dipyrromethene (BODIPY) chromophore in a liquid state, as well as to remark the main underlying photophysical signatures triggering such photonic behavior. First, we describe their light absorption and fluorescence properties in solution. This spectroscopic study is supplemented with quantum mechanics calculations and electrochemical measurements. Afterward, the dyes are tested as active media of tunable lasers under transversal pumping. The recorded laser efficiencies and photostabilities are correlated with the registered photophysical properties identifying the main structural guidelines and photonic parameters, which rule the laser bands’ position, intensity, and stability. As a result, we provide a comparative dataset of the laser performance, not available hitherto. Besides, the unraveling of the complex molecular structure-photophysics-laser relationship should help in the rational design of new tunable dye lasers with an improved photonic response along the entire visible region and reaching eventually the near infrared.",book:{id:"12081",title:"Dyes and Pigments - Insights and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/12081.jpg"},signatures:"Alaitz Peñafiel, Ainhoa Oliden-Sánchez, Edurne Avellanal-Zaballa, Leire Gartzia-Rivero, Rebeca Sola-Llano and Jorge Bañuelos"},{id:"82706",title:"Applications of Near-Infrared Spectroscopy (NIRS) in Fish Value Chain",slug:"applications-of-near-infrared-spectroscopy-nirs-in-fish-value-chain",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.105736",abstract:"Near-infrared spectroscopy (NIRS) has undergone a significant evolution in the last years due to the numerous scientific studies that revealed its potential for industrial applications, attracting a growing interest in the food sector. Furthermore, new advances have allowed the reduction in size and cost of the NIR devices, making them appropriate for on-site determinations. The complex structure of the fish value chain, combined to its high market value, makes this sector particularly vulnerable to fraud and adulteration practices. Also, the perishable nature of fish and fish products, as well as the lack of traceability, arises the urgent need for a fast, reliable and portable tool capable of precisely characterizing the quality and authenticity of the product while also ensuring its safety. In this chapter, the capabilities of NIRS combined to several chemometric techniques for quality, authenticity and safety applications are presented through an extensive review of the most recent research works.",book:{id:"11564",title:"Infrared Spectroscopy - Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11564.jpg"},signatures:"Sonia Nieto-Ortega, Rebeca Lara, Giuseppe Foti, Ángela Melado-Herreros and Idoia Olabarrieta"}],onlineFirstChaptersTotal:58},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:27,paginationItems:[{id:"83092",title:"Novel Composites for Bone Tissue Engineering",doi:"10.5772/intechopen.106255",signatures:"Pugalanthipandian Sankaralingam, Poornimadevi Sakthivel and Vijayakumar Chinnaswamy Thangavel",slug:"novel-composites-for-bone-tissue-engineering",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biomimetics - Bridging the Gap",coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg",subseries:{id:"8",title:"Bioinspired Technology and Biomechanics"}}},{id:"82800",title:"Repurposing Drugs as Potential Therapeutics for the SARS-Cov-2 Viral Infection: Automatizing a Blind Molecular Docking High-throughput Pipeline",doi:"10.5772/intechopen.105792",signatures:"Aldo Herrera-Rodulfo, Mariana Andrade-Medina and Mauricio Carrillo-Tripp",slug:"repurposing-drugs-as-potential-therapeutics-for-the-sars-cov-2-viral-infection-automatizing-a-blind-",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82582",title:"Protecting Bioelectric Signals from Electromagnetic Interference in a Wireless World",doi:"10.5772/intechopen.105951",signatures:"David Marcarian",slug:"protecting-bioelectric-signals-from-electromagnetic-interference-in-a-wireless-world",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82586",title:"Fundamentals of Molecular Docking and Comparative Analysis of Protein–Small-Molecule Docking Approaches",doi:"10.5772/intechopen.105815",signatures:"Maden Sefika Feyza, Sezer Selin and Acuner Saliha Ece",slug:"fundamentals-of-molecular-docking-and-comparative-analysis-of-protein-small-molecule-docking-approac",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. 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