The mental act, way of understanding, and way of thinking.
\r\n\tRecent advances regarding pathogenesis, cardiovascular risk assessment, prediction of damage, and recent advances in treatment, including tolerogenic and biological agents, are welcome to be included in this book. Relevant contributions regarding standard therapies and their optimal use, as well as the role of new therapeutic options, either in combination with previous agents or alone are of interest.
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Dr. Lionaki obtained her MD from the National and Kapodistrian University of Athens and has a Ph.D. degree in \"Membranous Nephropathy”. She is an expert in the field of 'Glomerular Diseases' as a result of a fellowship for more than 2 years at the Nephrology Department of the University of North Carolina, at Chapel Hill in the USA.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"213115",title:"M.D.",name:"Sophia",middleName:null,surname:"Lionaki",slug:"sophia-lionaki",fullName:"Sophia Lionaki",profilePictureURL:"https://mts.intechopen.com/storage/users/213115/images/system/213115.png",biography:"Sophia Lionaki, MD, PhD is an Assistant Professor In Nephrology in the National and Kapodistrian University of Athens, Greece. She obtained her MD from National and Kapodistrian University of Athens, Greece in 1996 and has a Ph.D degree on \"Membranous Nephropathy”. 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After further observation, it turns out that the IQ of the student was at an average level even above average. For cases like this, the student can be suspected of having dyscalculic symptoms or mathematics learning disabilities (MLD). Based on the results of the study, the number of people with MLD according to Strauss is 5–8% of school-age children [1], while according to Adler, the number of people with dyscalculia is 5–6% of all children [2].
Research on dyscalculia is still ongoing. Researchers, especially in the United Kingdom and the United States continue to conduct studies to study dyscalculia in greater depth. Therefore, the understanding and understanding of dyscalculia will continue to develop. The following are some of the dyscalculia definitions issued by both formal institutions and individual researchers. Definition of dyscalculia issued by the National Center for Learning Disabilities is as follows: dyscalculia is a term related to learning difficulties in mathematics. Although learning barriers differ from person to person, the general characteristics are as follows: difficulty in numerating, learning numbers, and doing mathematical calculations; difficulty in measurement, showing time, counting money, and estimating the number; problematic in mathematical intelligence and problem-solving strategies [3].
In general, dyscalculia is an umbrella term used for various difficulties in learning mathematics, such as developmental dyscalculia, mathematical difficulties, difficulty learning numerical concepts, and difficulties about learning number concepts.
There are many studies that discuss MLD students, with a different research focus: first, the research that focuses on the identification or criteria of MLD students; second, the research that focuses on how MLD students think in learning mathematics; and third, the research that focuses on finding solutions to learning mathematics in MLD students. The detailed of the research focus is as follows:
The study of the identification and criteria of MLD students has been carried out by several researchers, including the following: Geary described dyscalculia as a numerical and arithmetic difficulty caused by brain injury; he uses this term to describe a population of 5–8% of school-age children who have a cognitive disorder that affects their ability to learn concepts or procedures in one or more areas of mathematics [4].
Next the opinions of several experts about the criteria of MLD students will be described:
students with an average IQ whose standardized test scores are below the 20th or 25th percentile [4];
slower and often make mistakes in processing the representation of numbers, for example, the symbol number “3” and the equivalent of the non-symbol “◆◆◆” [5];
make mistakes in comparing and estimating numbers [6];
wrong in doing arithmetic calculations [7]; and
wrong in solving numbers problems that are very easy, for example, 4 × 5 = 20 [8].
The researchers identified students with MLD using standardized test results, for example, the Woodcock-Johnson Test of Achievement and the Wide Range Achievement Test, by looking at students who were below the 20th or 25th percentile [9]. Lewis further tightens the criteria for identifying MLD students, which combines the following three criteria:
students score below 25th percentile on standardized mathematics tests;
the results of observations and interviews revealed that there was no influence of environmental or social factors on students
after being given treatment, the effect of the treatment on increasing mathematical ability is very less. To find this out, Lewis made a comparison with a control class whose members were not MLD students [10].
In identifying students with MLD, Lewis [9] suggests that if researchers use self-developed identification instruments, it is also necessary to include the results of standardized measuring instruments as a comparison. The next suggestion is to apply a cutoff under the 10th percentile; observing longitudinal data showing that learning difficulties in mathematics are long-standing, and researchers must distinguish the difficulty of learning mathematics is the result of cognitive or non-cognitive factors. To do this it is recommended to conduct a demographic analysis of the respondents, for example, socioeconomic status, ethnicity, and mother tongue. This can also be done with qualitative methods, such as interviews, questionnaires, observation of students, parents, and teachers, to find out the factors that lead to the low mathematical achievement of students.
The study of how MLD students think in learning mathematics has been carried out by several researchers, including the following:
Lewis states that students with MLD have a different mindset in understanding fractions, she looked at students with MLD does not mean they have deficiencies in understanding the concept of fractions, but there are differences in the way of thinking in understanding fractions [11]. Then Lewis states that students with MLD experience obstacles in learning fractions, especially on the topic of fraction comparison, both fraction comparisons with the same denominator, as well as in fractions comparisons involving fractions of half; in this study Lewis suggested examining students’ understanding of the quantity of fractions [12].
Hunt et al. [13] state that MLD students have obstacles in mastering the concept of fractions by learning part-whole models. Newton et al. [14] state that the main error pattern in understanding fractions in MLD students is the use of traditional algorithms that are wrong.
The study of alternative mathematical learning solutions for MLD students has been carried out by several researchers, including the following:
Shin and Bryant state that good fraction teaching by MLD students must involve the following 5 aspects: real objects and visual representations such as pictures and number lines, explicit and systematic learning, various time frames and sets of examples, heuristic strategies, and use real problem [15].
Mazzocco et al. state that visual models can be used as alternatives when helping MLD students understand fractions [16]. Gersten et al. [17] state that in assisting MLD students, practitioners are expected to take the following steps: (a) teach students with diverse teaching examples; (b) directing students to say the thoughts and solutions of a problem; (c) teach students to visualize math problems that they face; (d) teach students with diverse/heuristic strategies; (e) the teacher prepares a partner/discussion partner for MLD students; (f) teach MLD students with explicit instructions; (g) the teacher prepares the correct variety and sequence of examples;
Shin and Bryant [15] state that the use of a computer program, Fun Fraction, can help MLD students solve problem-solving in the form of stories. Virtual manipulation in Fun Fraction helps problem-solving skills because students are assisted by this program in representing the problem stories they are dealing with.
Finally, Tian, Jing, and Siegler, state that the use of an optimal number line model can help MLD students understand fraction size and calculation [18].
In this chapter, we focus on students’ ways of thinking in fractions learning. It is needed as an essential first step toward effective instructional methods. We use the theory of mental act, ways of thinking, and ways of understanding from Harel. Furthermore, we also analyze the error pattern of MLD students when they learn fractions. The results of this study are expected to add to the discourse of educational scholarship, especially on the teaching and learning mathematics in an inclusive setting for students with MLD.
Fractional topics include material in mathematics that is difficult to explain. This is because fraction is one of the topics in mathematics that requires high-level and complex thinking. Definition of fractions according to Clarke et al. [19]:
“Fractions are symbolic-shaped expressions that represent the quotient of two numbers
In many classes, fractions are taught only in a procedural way. The teacher usually teaches fractions by applying the method of equalizing the denominator, by calculating the Least Common Multiples (LCM). On the other hand, according to Hiebert and Wearne [20], with this procedural method, students will only gain procedural understanding or syntax thinking. Students will not understand the relationship between fractions, in other words, students’ conceptual understanding (semantic thinking) will be weak.
How can students gain a conceptual understanding of fractional material? Riccomini suggests two teaching strategies for better fraction learning; the two strategies are learning fractions by using number lines and the use of diverse representations [21]. The use of number lines and paper folding as representations is also suggested by Wyberg et al. [22].
Several other research results also support the use of diverse representations. Dey and Dey suggest the use of geometry representations; addition, subtraction, multiplication, and division operations can be represented geometrically [23]. Furthermore, Clark and Roche suggest the use of games in fraction learning; the game is done like a monopoly game using a kind of broken board, dice, and involves all students in the class [24].
The use of image representation is suggested by de Castro [25]. The same representation, using colored art drawings was suggested by Scaptura et al. [26]. Fractional learning using technology was suggested by Mendiburo and Hasselbring; they also prove that teaching fractions with technology are as effective as teaching fractions that use physical manipulation [27].
Other researchers, Lesh, Posh, and Behr stated that students gain a better understanding when they can identify and model mathematical concepts through various representations [28]. Furthermore, the Principle and Standards for School Mathematics suggest that students represent their mathematical ideas so that mathematical ideas make sense according to students [29]. One learning model that offers the use of diverse representations is the Lesh Translation Model.
Lesh Translational Model states that basic mathematical ideas can be represented in 5 ways: real (manipulative) objects, images, real-world contexts, verbal symbols, and written symbols. This model is illustrated by the followingFigure 1:
Lesh translation model [
Lesh Translational Model emphasizes interactions within and between representations. The arrows between one representation and another represent the intermodal translation, while the arrows in one mode represent the translation in the mode itself. This model suggests that a good understanding of mathematical ideas requires experience from various modes (ways) and the experience of making connections between and within these modes of representation. A translation requires interpretation of ideas that differ from one mode to another. This activity with its intellectual relations activity reflects dynamic learning.
According to Harel [31], human reasoning involves many mental actions such as interpreting, guessing, concluding, proving, explaining, compiling, generalizing, applying, predicting, classifying, searching and solving problems. He states that way of understanding is a certain cognitive product of mental actions carried out by an individual. For example, after seeing the symbol
Ways of Thinking is a cognitive characteristic of the Mental Act. The cognitive characteristics of the Mental Act are inferred from observations of Ways of Understanding (cognitive products of mental actions). For example, a teacher who follows students’ mathematical behavior might conclude that students’ interpretations of mathematical symbols are inflexible, there are absolutely no quantitative views, or for example, students’ interpretations of symbols are flexible and connected with other concepts. Another example, the teacher can conclude that students’ proof of mathematical statements is based on empirical evidence, or based on deductive reasoning [31].
Here are the results of the data analysis from three students with MLD; we found mental acts, ways of understanding, and ways of thinking as follows:
Here is one example of student work that used mental act problem-solving (Figure 2).
Mental act problem-solving of MLD student.
In Figure 2, the student solves a problem: a tailor receives
A problem-solving approach is a cognitive characteristic of mental act problem-solving. From the results of the analysis of the answers, it was found that 8 students did the problem-solving approach. In the answers above, it appears that students understand the questions and answer them using a problem-solving approach, in the form of an invert multiple algorithm (IMA) strategy in fraction division operations.
The solution is a cognitive product of mental act problem-solving. From the results of the analysis of answers, obtained student answers are examples of the way of understanding solution.
The second identifiable mental act of MLD students is interpreting. The example of student work is as follows (Figure 3).
Mental act interpreting of MLD student.
In Figure 3, the student is asked to describe fractions
Diverse interpretation of mathematical symbols is a cognitive characteristic of mental act interpreting (way of thinking). From the analysis of MLD student test result data, it was found that he made a fractional interpretation in the form of images, namely rectangular and circular images, as shown above. Interpretation is a cognitive product of mental act interpreting. From the results of the analysis of MLD student answers, it is an embodiment of the way of understanding interpreting, namely interpretation. The students’ interpretation of the fractions
We summarize these findings in Table 1.
Mental act | Way of understanding | Way of thinking |
---|---|---|
Problem-solving | Solution | Problem-solving approach: invert multiply algorithm |
Interpreting | Interpretation | Multiple interpretations (as pictures of the square, rectangle, etc.) |
The mental act, way of understanding, and way of thinking.
Some patterns of errors made by MLD students are as follows:
The pattern of mistakes of the three students is wrong in applying the denominator equalization procedure. Here is a picture showing this (Figure 4).
Example of an error pattern in applying the denominator equalization procedure to the fraction addition operation.
In the questions, participants are asked to solve two fraction addition questions. In the first problem (part a), students are asked to solve questions
In the second problem (part b), students are asked to solve questions
The second error pattern is very interesting, namely, students apply the denominator equalization procedure in multiplication operations. Here is a picture showing this (Figure 5).
Example of error pattern applying the denominator equalization procedure to multiplication operations.
In the problem, students are asked to solve questions
The third error pattern is very interesting, namely, students turn the first syllable in a fraction division operation. Here is a picture showing this (Figure 6):
Example of the first syllable error pattern in a fraction division operation.
In the second problem (part b), students are asked to solve questions
MLD students solve fractions problem procedurally, they apply common denominator approach, drawing a picture, direct multiplied strategy, and invert multiply algorithm in solving fractions problems. They cannot practice the other strategies like using a benchmark or residual which demands the ability to infer and explain. Therefore, we conclude MLD students only perform two mental acts, which are problem-solving and interpreting. They could not develop other mental acts like explaining or inferring.
Some interesting findings when MLD students solve fractions problem are: (1) they know the procedure of common denominator approach in fraction addition operation, however, they mistakenly apply the procedure; (2) in multiplication and divisions operation, they are familiar with the procedure, however, they mistakenly apply the procedure. The two finding is in line with Newton et al. research, they revealed that the main pattern of error in fraction understanding on MLD students is the use of traditional false algorithms [14]. These findings also in accordance with the research of Mazzocco et al., which show that the difficulties in fraction learning are still felt by MLD students until they are in grade 8 [16]. Other researchers also had the same research result, which stated that MLD students make a mistake in performing arithmetic calculations [7].
Another previous research explained that students with MLD have a different ways of thinking in understanding fractions. Lewis considered that the MLD students did not mean to have a lack of understanding of fractions; however, they had different ways of thinking in understanding fractions [11]. We find that MLD students have different ways of thinking in understanding fractions addition operation; they differently understand the common denominator approach, they do not multiply the numerator by the same number with the denominator.
The other research findings deduced that adolescent MLD students are experiencing difficulties in fraction comparison subjects, either fractions comparisons with the same denominator or in fractions comparisons involving a half fraction [12]. Lewis suggested to investigating younger MLD students as the subject. We involved younger students with MLD in our research, a similar result is found, that is MLD students have difficulties in solving fractions comparison problems [33].
In our finding, partitioning activities, which are beneficial for regular students, but not necessarily helpful to MLD students; this may happen because MLD students do not follow a developmental pattern like their regular peers. In accordance with our findings, Lewis explained that partitioning activity was probably the root of understanding the quantity of fractions in regular students; MLD students may not follow this pattern of development [10].
According to Brousseau, the appearance of learning obstacle in mathematics can be caused by three obstacles, namely ontogenic obstacle (mental learning readiness), didactical obstacle (obstacle from teacher instruction or teaching material), and epistemological obstacle (students’ knowledge which has limited application context) [34]. In the context of Brousseau theory, the three error patterns of the MLD students in fractions learning is prone to the type of epistemological obstacle, that is MLD students already know fractions concept, however, they have limited application context to the other fractions problems [35].
We found only two mental acts with corresponding WoU and WoT, namely problem-solving and interpreting. On the analysis of MLD students, it was found an interesting thing in the mental act problem solving, i.e., the student knew the common denominator approach in the operation of fraction addition, but the practice is still wrong. The same thing is also found in multiplication and division operation. Surprisingly, students use the common denominator approach in the fraction multiplication. In the division of fraction, students mistakenly apply the invert multiply algorithm.
The results of this study can be used by the teachers as a guideline when teaching fractions to students. Future research is recommended to analyze the error patterns of MLD students with other topics in mathematics, such as geometry.
Electrospinning is a highly versatile technique to produce continuous fibers with diameters ranging from several micrometers down to few nanometers by applying a high voltage on a solution or melts, mainly from polymers. At nanoscale, several superior characteristics occur such as large surface to volume ratio that can reach values as large as 103 times of that of micrometer, easy adaptability to surface functionalization, and extraordinary supreme mechanical properties such as stiffness and tensile strength. These outstanding characteristics make electrospun nanofibers an optimal candidate for many important applications [1].
Beside electrospinning, a number of processing methods have been used in recent years to produce polymer nanofibers, such as drawing, self-assembly, template synthesis, and phase separation [2]. Each of these techniques has its limitation, whereas drawing is only limited to viscoelastic materials that can handle the stresses developed during pulling to produce nanofibers, while self-assembly is time consuming in producing continuous polymer nanofibers. Template synthesis uses nanoporous membrane as a template to produce nanofibers of solid (a fibril) or hollow (a tubule) shape. Phase separation takes relatively long time to transfer solid polymer into nanoporous foam. Electrospinning process due to its ease of fabrication appears to be the only technique, which could be further developed for mass production.
The term electrospinning has been used relatively recently; however, its fundamentals dated back more than 60 years earlier. Formhals published a succession of patents [1, 3, 4, 5, 6] from 1934 to 1944. Through this series, he specified the experimental setup for producing polymer filaments using electrostatic force, whereas the polymer solution was exposed to electric field through two electrodes with different polarity. One is placed into the solution, and the other onto the collector. Once the jet solution ejected out from a metal spinneret, it evaporated to become fibers and these fibers were collected on the collector. The potential difference depended on the properties of the solution such as polymer molecular weight and viscosity. The problem occurred that was the fibers favored to stick to each other as well as to the collectors. This problem was due to the insufficient distance between the spinneret aperture and the collectors, which led to inadequate time for jet solution to evaporate. In 1936, C.L. Norton approach was patented due to his contribution to electrospinning from a melt rather than solution using air blast to boost fiber formation [7], Rozenblum and Petryanov-Sokolov [8] in 1938 produced electrospun fiber that was developed into filter materials. These filter materials were then mass manufactured for gas masks. Sir Geoffrey Ingram Taylor stablished the underpinning of a theory for electrospinning between 1964 and 1969. He explained the mathematical model of the cone shape of the fluid droplet under the electric field [9, 10, 11]. In the report of the National Institutes of Health (NIH), The Small Business Innovation Research 1988, Simon produces a submicron- and nanoscale fibrous mats from electrospinning. These mats were especially created for use as substrates
The standard laboratory setup for electrospinning apparatus consists of spinneret connected to high-voltage (5–50 kV) direct current power supply as illustrated in Figure 1.
Electrospinning apparatus schematic.
There is a variety of solutions that can be loaded into the syringe, for example, polymer solution, sol–gel, particulate suspension, or melt [13].
By controlling the processing parameters, different nanofiber morphologies can be obtained (Figure 2a–m [14]), beaded, smooth [15], helical [16], ribbon [17], necklace-like [18], porous [18], core-shell [19], hollow [20], multichannel-tubular [21], nanowire-in microtube [22], muli-core cable-like [23], tube-in-tube structured nanofibers [24].
Different nanofiber morphologies: (a) beaded (b) smooth, (c) helical, (d) ribbon, (e) necklace-like, (f,g) porous, (h) core-shell, (i) hollow, (j) multichannel-tubular, (k) nanowire-in microtube, (l) muli-core cable-like (m) tube-in-tube structured nanofibers.
The main properties that should be provided in any material to be used as a sensor are: firstly, to be responsive to the external stimuli; secondly, this response can be accessible to electronic interface; thirdly, this has a large specific area since sensing preferentially occurs at interface. The material that possesses the first property is called smart material. The stimuli can be pressure, temperature, PH, moisture, chemical substances, electric, magnetic field, or light. In order for these smart materials to a sensor, it should act as a transducer. That means to response to the external stimuli in a way which can be measurable. In other words, it converts the external stimuli into a quantity that can be measurable.
Electrospinning manifests the capabilities of smart materials at the nanoscale dimension, especially as sensing materials. At nanoscale dimensions, many features are accessible, for example, excellent mechanical properties, especially flexibility, high porosity, large surface area, ability to surface functionality, and the ability to produce not only one-dimensional (1D), but also three-dimensional (3D) materials. Due to dramatic decrease in the diameter of the fibers, this has a great impact on the surface area, which is significantly increased, consequently the number of sites increase to interact with the external environment more effectively. High porosity provides utmost channels for transporting among nanofibers in electrospun mats, hence speeding up the transportation mechanism and increasing sensitivity. Another aspect of electrospinning is in its ability to form continuous nanofibers. This feature is so important in sensors, because sensors are usually assembled into a certain measuring instrument or analog-to-digital conversion circuit; therefore, it should provide a stable continuous circuit to supply a path for the current. Hence, electrospinning is irreplaceable to provide a stable circuit. Additionally, electrospinning makes use of various materials from inorganic to organic matters.
Smart materials, also named stimuli-responsive materials, are capable of undergoing reversible physical/chemical change upon exposure to external stimulus, such as temperature, PH, electrical, magnetic, light, chemicals, ions. Integration of these stimuli responsive materials with nanotechnology, such as electrospinning, has enormously accelerated the development of sensors.
Capacitive sensors mainly depend on changing the relative permittivity of the dielectric material between two conducting electrodes. Capacitive devices are often used as displacement and pressure sensors.
Yang et al. [25] developed a flexible capacitive pressure sensor based on electrospun polyvinylidene fluoride (PVDF) nanofiber membrane with carbon nanotubes (CNTs). The fabrication process and schematic diagram of CNT-PVDF composite nanofiber are shown in Figure 3a,b. Two pieces of indium tin oxide polyethylene terephthalate films connected with cooper wires were fixed on the top and bottom surface of the composite nanofiber membrane as electrodes to record the capacitance variation under external pressure. The schematic diagram and the actual diagram of the single sensor are shown in Figure 3c. The SEM images of the composite nanofibers are shown in Figure 3d,g with different CNT weight ratios of 0.03, 0.05, 0.1, and 0.2 wt % of PVDF. At the beginning, the increase of CNT led to decrease the diameter of nanofibers, and then, the diameter increases again. This is because the when CNT increases the conductivity, the electrostatic force between the collector and the syringe spinneret will increase. Therefore, the nanofibers will be pulled thinner. Any further increase of CNT will lead to increase of nanofibers diameter as the CNTs tend to agglomerate due to strong Van der Waals force.
Flexible capacitive pressure sensor: (a) schematic of the fabrication of the composite nanofiber. (b) schematic diagram of the composite nanofiber. (c) Diagram of the sensor. (d)–(h) SEM images of the composite nanofiber membrane with 0.03, 0.05, 0.1, 0.2 wt % carbon nanotube additions, respectively [
By increasing the permittivity and decreasing the young’s modulus of the CNT-PVDF dielectric layer, the capacitive sensor exhibited high sensitivity (∼0.99/kPa) with a composition of 0.05 wt% CNTs (Figure 4a), fast response (∼29 ms), and excellent cyclic loading/unloading stability (>1000 cycles) (Figure 4b).
Characterization of the pressure sensing performance of the flexible capacitive sensor. (a) The relative change in capacitance of the sensor with different weight ratio CNTs addition under low pressure applied. (b) Experimental systems for dynamic pressure applying and measuring capacitance, and enlarged view of a portion of the figure.
Resistive sensors rely on the measuring the change of electrical resistivity as a variable of the amount of the reactive analytical samples through surface reaction. Up to now, numerous attempts have been carried on to develop ultrasensitive sensors to detect NH3, CO2, CO, O2, H2S, moisture, volatile organic compounds (VOCs) [26, 27, 28, 29, 30]. Resistive sensors based on electrospun nanofibers provide high and quick gas response
Resistive sensors based on metal oxide semiconductors (MOS) are the most simple and versatile gas sensors [33].
The resistance of the metal oxide is changing in accordance with the adsorption of the gases. One-dimensional (1D) nanostructured MOS have attracted much attention as chemical sensor materials as a result of their large surface-to-volume ratio, high porosity, excellent surface activities, and high surface charge modulation depth. ZnO, SnO2, TiO2, NiO, and LaFeO3 are the most 1D MOS, which have been widely developed in the creation of highly sensitive gas sensors [34, 35].
The sensing mechanism of MOS gas sensors can be illustrated as follows:
In pure air, donor electrons in metal oxide attract to the oxygen, which is adsorbed into the surface of sensing material, preventing current flow (Figure 5a), while in the presence of the target gas (Figure 5b), oxygen reacts with the reducing gases. Hence, surface density of adsorbed oxygen decreases, and those electrons are then released into MOS, allowing current to flow freely through the sensor.
Sensing mechanism of MOS gas sensors: (a) in clean air and (b) in the presence of the target gas.
Abundance of n-type semiconductors such as ZnO, SnO2, TiO2, In2O3, WO3, and ZnO/SnO2 have turned out to be excellent gas materials for detecting both reducing and oxidizing gases, including H2, NH3, ethanol, acetone, and toluene. TiO2 is the most well-known MOS used in ultrasensitive resistive sensors. Kim et al. have indicated the use of TiO2 nanofibers as a detector for NO2 [30]. Wang et al. reported that ZnO nanofibers with an average diameter of 150 nm display excellent sensing properties against ethanol at an operating temperature of 300°C, with a rapid response of about 3 s, including short recovery time of about 8 s and high sensitivity [36]. Lately, SnO2 has attracted much attention because of its high transparency, semi-conductivity, wide-band gap, and huge magneto-optic and chemical sensing effects [37, 38]. A highly porous SnO2 nanofibers were prepared by combining electrospinning with oxygen plasma etching. They displayed fast response (7 s), wide linear response range, and low detection limit (< 1 ppb) [39].
In addition, doping is an efficient method to improve the sensing properties of the sensors. Li et al. have demonstrated that LiCl-doped TiO2 nanofibers have an enhanced sensitivity toward humidity better than pure TiO2 nanofibers [40]. Moreover, the composite nanofibers have ultra-fast response and recovery time. Zhang et al. developed double-layer ZnO/In2O3 composite nanfibers for sensing ethanol. ZnO/In2O3/ZnO displayed improved and excellent sensing properties compared with ZnO nanofibers (detection limit of 1 ppm, shorter response, and recovery time of 2 and 1 s, respectively).
In addition to n-type semiconductors, p-type semiconductors have also been used to prepare vapor sensors, including NiO, Cr2O3, LaFeO3, CuO, LaOCl/NiO, etc. Fan et al. [41] produced LaFeO3 nanofibers-based ethanol sensor with good reversibility and selectivity and fast response and recovery time. Electrospun LaOCl/NiO composite nanofibers have significant performance in ethanol sensing against CO, NO2, H2, NH3, due to incorporation of NiO that catalyzes gas sensing reaction [42].
Many methods have been carried on to improve the sensitivity, response, and recovery time, for example, combining p-type with n-type metal oxide semiconductors to form p-n junction remarkably improving the sensing characteristic [43, 44], functionalizing the surface of nanofibers with catalytic nanoparticle (such as Ag, Pd, Pt) [45], and doping salts (KCl, LiCl, NaCl, and MgCl2) into nanofibers, especially in humidity sensors [46].
Organic polymers, especially conducting polymers (CPs) as an alternative to inorganic semiconductors, provide attractive features such as mechanical flexibility, easy processing, and adaptable electrical conductivity. Many research efforts have been dedicated to the development of nano-sensors based on CPs such as PANI, polythiophene, and their derivatives. However, CPs have poor solubility in common solvents, which restrict its application. Many routes have been developed to overcome this drawback, for example, incorporating CPs into other polymeric systems (such as PS, PEO, CA) or synthesized in other conducting forms (oxidized, reduced) [47]. The charge transport for CPs is primarily due to hopping mechanism. This hopping occurred because of changing polymer resistance in the presence of a sensing gas. This change can be due to chemical change (doping/de-doping), conformational change, or polymer swelling.
Electrospinning provides abundance of activated sites for CPs immobilization due to its unique features, such as large surface area, high porosity, and large stacking density. Pinto NJ et al. [48] demonstrated that the electrospun-isolated nanofibers of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonic acid) can be used to sense vapors (NH3, HCL, NO2, aliphatic alcohols).
Hybrid nanofiber-based sensors have been developed to overcome the drawbacks of inorganic nanofiber-based sensors (require high-operating temperature) and organic nanofiber-based sensors (low sensitivity). Few researchers have investigated hybrid nanofibers-based sensing devices, and they got promising results in terms of sensitivity, response time, and reversibility [49, 50]. Researchers should devote their work to improve stability, selectivity, and reusability of the sensors.
All the aforesaid nanofibers-based sensors depend mainly on electrical sensing principle; however, in some cases, electricity is not suitable for the target sensing analytes. Hence, the importance of using optical sensors is necessary. Among the optical properties that have been utilized at sensors is reflectivity, refractive index, color, and absorption coefficient. Refractive index has been investigated by our work team, and it was effective.
Fiber optic sensor technology has been rapidly developed in the past 30 years due to the innovations in telecommunication, semiconductor, and electronics sectors that have significantly reduced the prices of optical components and stimulated the development of optical fiber sensor [51]. Optical fiber sensors are capable of measuring a wide variety of physical properties, such as chemical changes, strain, electric and magnetic fields, pressure, temperature, displacement (position), radiation, flow, liquid level, vibrations, and light intensity. Optical fiber sensors exhibit a number of advantages over the conventional electrical and electronic sensors:
Are non-electrical devices
Require small cable sizes and weight that enable small sensor sizes
Allow access into inaccessible areas
Permit remote sensing
Immune to radio frequency and electromagnetic interference
Do not contaminate their surroundings and are not subject to corrosion
Provide high sensitivity, resolution, and dynamic range
Offer sensitivity to multiple environmental parameters
It is believed that optical fiber sensors will replace the conventional devices for the measurement of various physical, chemical, and biological parameters. Optical fiber sensors are dielectric devices that are chemically inert. They do not require electric cables and are technically ideal for working in hostile media, and corrosive environment for remote sensing applications [52, 53, 54, 55].
In the following section, we will display some of our team efforts of hybrid fiber-optic/nanofiber sensors developments.
Petrík et al. [52] have produced SiO2 nanofibers. The surface of SiO2 nanofibers was functionalized with enzymes. Figure 6 shows the SEM images of nanofibers with and without enzyme immobilization. The functionalized nanofibers were attached at the tip of
SEM pictures of nanofibers without (a) and with (b) immobilized enzyme.
Setup of the tested optical fiber sensor with an enlargement of the detection part.
Reflected intensity vs. concentration of a model enzyme-substrate.
The results of these experiments are very optimistic to the effectiveness of the prescribed optic fiber system with nanofibers. This system can be used as a basis of a wide family of optic fiber sensors sensitive to various chemical and biological substances. The proposed optical fiber sensor can be integrated into security systems for fast and cost effective.
Main advantages of the approach are as follows:
Chemically inert materials—possibility to disinfect/sterilize
Miniature dimensions
Sufficiently high sensitivity
Another work effort from our group is a trial to estimate the water content in brake fluid using hybrid optical fiber/nanofiber as it will be explained later.
We have used similar approach in a proof-of-concept study of using nanofiber/fiber-optic sensors for monitoring of waste-water bio-cleaning process.
Activity of bacteria in sludge water was monitored using online and offline optical fiber sensing system that utilizes the nanofibrous membranes. The used optics showed reasonable sensitivity levels to the slight changes in water compositions due to the presence of slurry matters and the formation of biofilms on the surface of the nanofibrous membranes. In general, the online setup showed better performance compared with the offline system that has inhomogeneous formation of bacterial films. As a future continuation of this work, other fibrous systems with higher compatibility and growing conditions for bacteria will be used. Also, functionalization of the fibers with elements that attract bacteria will be implemented in the upcoming work. Moreover, the experimental setup will adopt an online measurement system for mobilized and flowing bioreactors. The experimental setup is shown in Figure 9. An example of the sensor response to the bacteria activity is illustrated in Figure 10.
Pictures for the used fiber optics and the online measurement setup.
Reflected intensity as a function of time detected by the hybrid fiber optic/nanofiber sensor.
Focus of this research is to build and investigate an optical fiber sensor based on silica nanofibers prepared by a reliable and low-cost electrospinning technique to detect water content in DOT-4 brake fluid. To the best of our knowledge, this is a novelty study of optical fiber sensor to detect water content in an aqueous substance using electrospinning nanofibers.
The nanofiber processed by electrospinning has a larger specific surface area compared with conventional coating film, which can absorb a large number of water molecules. In some recently published articles [56, 57], dielectric properties of silica-based hybrid nanostructures and thin films have been investigated in which capacitance and dielectric constant act as a function of frequency. Batool et al. [58] studied the effect of RH on dielectric response of SiO2 nanofibers; however, it is rarely investigated the effect of RH on refractive index of SiO2 nanofibers.
The method used in this work involves utilization of silica nanofibers. The full description of preparation of the nanofibers can be found in patent WO 2017/186201 [59]. The composite PVP/SiO2 nanofibers were left in the air for 24 h for hydrolysis of TEOS. Subsequently, PVP/SiO2 nanofibers were annealed at 800°C for 6 h in furnace to obtain pure SiO2 nanofibers. Figure 11a shows the scanning electron microscope (SEM) image of pure SiO2 nanofibers after the removal of PVP, annealed at 800°C for 6 hours. The nanofibers have diameters ≈ 150 ̶ 200 nm. Figure 11b shows the energy-dispersive spectrum of SiO2 nanofibers. The presence of atomic % of Si and O in the sample indicates formation of SiO2 and complete removal of PVP. Si-O-Si bonds (siloxane groups) at 1087 and 797 Cm−1 become more intense after heat treatment as shown in Figure 11c.
(a) SEM images of SiO2 nanofibers heat treated at 800°C for 6 h, (b) EDS spectrum, (c) Fourier-transformed infrared spectroscopy of TEOS/PVP electrospun fibers before (B) & after (A) heat treatment from both sides interior (i) & exterior (o).
Measurements were made with 0–7% water added to the brake fluid. The amount of water that was added to the brake fluid was determined according to dry basis moisture content (designated Md in the text) is described by the percentage equivalent of the ratio of the weight of water (WW) to the weight of the dry matter (Wd), herein is DOT-4.
Dry Basis Moisture Content is defined by Eq. (1):
Commercial brake fluid tester was utilized for checking the percent of water content presented in brake fluid.
Silica nanofibers were glued on the tip of 2x Multimode optical fiber 50/125 μm, optical power meter as a source of input light, and a detector of the reflected light. OFS has been immersed in a brake fluid while changing its water content.
Figure 12 shows the change in the power intensity as a function of water content in brake fluid which is almost linearly. That is probably related to water molecules that will be absorbed and concentrated in the pores of the silica nanofibers. This effect will alter the refractive index (RI) of the silica nanofibers, hence changing the optical power intensity. As a result, the accumulation of the water molecules will cause the increase of effective refractive index of the surrounding medium. This will lead to the leakage of the light through evanescent field [60, 61]. This proposed sensor based on reflected light intensity modulation. Based on Fresnel reflection, a proportion of lights are leaked when the sensor is in the liquid. This amount of light depends on the refractive index of the liquid. For normal incidence, the reflectance simplifies to the following equation Eq. (2).
OFS response to the water change in brake fluid in terms of changing light intensity.
The experiments are still going on while controlling humidity and temperature to assign the parameters, which could influence the accuracy and repeatability of the potential sensor.
Hundreds of papers are being published per year on “sensing” nanofibers.
Electrospinning looks like the most versatile method for their fabrication. Many unique sensor designs require just mm2 of the nanofiber mat per unit (single use or multiple/continuous measurement). Definitely, they will not generate market opportunities for 1–2 m width production lines available on the market (Elmarco, Innovenso). The producers should probably consider the development of small volume special machines. Some of the “lab tools” the offer will probably fulfill the market needs.
Smart membranes/textiles are much more compatible with current production lines offered to the market. But the technological processes will be probably challenging and will need further development (chemistry, depositions of special substances, inter-operations, after-treatments, etc.).
This work was supported by the Ministry of Education, Youth and Sports in the Czech Republic under the “Inter Excellence – Action programme” within the framework of project “Micro-struCtural imaging as a Tool for modelinG fibrOus materiALS (μ-CT GOALS)” (registration number LTAUSA18135). Also, this work was supported by the Ministry of Education, Youth and Sports of the Czech Republic and the European Union - European Structural and Investment Funds in the frames of Operational Programme Research, Development and Education - project Hybrid Materials for Hierarchical Structures (HyHi, Reg. No. CZ.02.1.01/0.0/0.0/16_019/0000843).
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Among those parameters, reducing temperature gradient which decreases the thermal stresses is one of the key factors to improve the ceramic quality. Although realizing crack-free ceramics combined with a smooth surface is still a major challenge, through optimizing the parameters, it is possible for LPBF processed ceramic parts to achieve properties close to those of conventionally produced ceramics.",book:{id:"6306",slug:"additive-manufacturing-of-high-performance-metals-and-alloys-modeling-and-optimization",title:"Additive Manufacturing of High-performance Metals and Alloys",fullTitle:"Additive Manufacturing of High-performance Metals and Alloys - Modeling and Optimization"},signatures:"Haidong Zhang and Saniya LeBlanc",authors:[{id:"213235",title:"Prof.",name:"Saniya",middleName:null,surname:"LeBlanc",slug:"saniya-leblanc",fullName:"Saniya LeBlanc"},{id:"213239",title:"Dr.",name:"Haidong",middleName:null,surname:"Zhang",slug:"haidong-zhang",fullName:"Haidong Zhang"}]},{id:"59094",doi:"10.5772/intechopen.72973",title:"Structure and Properties of the Bulk Standard Samples and Cellular Energy Absorbers",slug:"structure-and-properties-of-the-bulk-standard-samples-and-cellular-energy-absorbers",totalDownloads:738,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"The development of additive technology revealed a real prospect of their use for the manufacture of complex shapes. Now, it is possible to produce parts that previously were either very difficult to produce using the subtracting technology and joining technology, or it was not at all feasible. In the manufacture of parts of complex shape, it is necessary to use a supporting structure, which is necessary to place such a way that they can be easily removed. Additionally, they must necessarily be absent in certain places. In this regard, the preparation model can take significant time to satisfy all of these, often conflicting, requirements. In this paper, we show optimization examples of the model preparation with support structures for parts manufactured at the facility EOSINT M270 and used in medicine and engineering. Additional emphasis is on the fact that, during the manufacture of parts, solidification’s modes of massive parts differ from those of the thin-walled portions of parts. The results of the complex studies on the different stainless steels (including martensitic) are described with an emphasis on their structure and mechanical properties. The results of a honeycomb energy absorbers, which are quite seldom produced by the additive technologies, are presented in this chapter.",book:{id:"6306",slug:"additive-manufacturing-of-high-performance-metals-and-alloys-modeling-and-optimization",title:"Additive Manufacturing of High-performance Metals and Alloys",fullTitle:"Additive Manufacturing of High-performance Metals and Alloys - Modeling and Optimization"},signatures:"Pavel Kuznetcov, Anton Zhukov, Artem Deev, Vitaliy Bobyr and\nMikhail Staritcyn",authors:[{id:"223064",title:"Dr.",name:"Pavel",middleName:null,surname:"Kuznetsov",slug:"pavel-kuznetsov",fullName:"Pavel Kuznetsov"},{id:"227212",title:"Mr.",name:"Artem",middleName:null,surname:"Deev",slug:"artem-deev",fullName:"Artem Deev"},{id:"227213",title:"Mr.",name:"Vitaliy",middleName:null,surname:"Bobyr",slug:"vitaliy-bobyr",fullName:"Vitaliy Bobyr"},{id:"227215",title:"Mr.",name:"Anton",middleName:null,surname:"Zhukov",slug:"anton-zhukov",fullName:"Anton Zhukov"},{id:"227216",title:"Mr.",name:"Mikhail",middleName:null,surname:"Staritcyn",slug:"mikhail-staritcyn",fullName:"Mikhail Staritcyn"}]},{id:"59742",doi:"10.5772/intechopen.74331",title:"Advanced Technologies in Manufacturing 3D-Layered Structures for Defense and Aerospace",slug:"advanced-technologies-in-manufacturing-3d-layered-structures-for-defense-and-aerospace",totalDownloads:1824,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"In the past 20 years, a great progress has been made in additive manufacturing techniques, which has led to numerous applications in aeronautical and defense structures. Though not all advanced materials and alloys, can be automatically layered by a rapid prototyping system or machine, several interesting application have seen the light of publicity in many sectors. Efforts are underway to apply the automated layering technologies in as many materials as possible, mostly nowadays plastics, reinforced-polymers, and metals can be processed by such systems in order to produce three-dimensional parts. The work is underway internationally in order to promote more and more applications of additive manufacturing or automated layering and to lower the costs in such systems. This paper aims at presenting a review of the additive manufacturing history presenting the major steps that lead to the explosion of this technology, and with a special focus on advanced 3D structures in aerospace and defense applications. An insight is also given on the four dimensions of manufacturing concept.",book:{id:"5759",slug:"lamination-theory-and-application",title:"Lamination",fullTitle:"Lamination - Theory and Application"},signatures:"Dionysios E. Mouzakis",authors:[{id:"107011",title:"Associate Prof.",name:"Dionysios",middleName:"E.",surname:"Mouzakis",slug:"dionysios-mouzakis",fullName:"Dionysios Mouzakis"}]},{id:"61242",doi:"10.5772/intechopen.76860",title:"Theory and Technology of Direct Laser Deposition",slug:"theory-and-technology-of-direct-laser-deposition",totalDownloads:1281,totalCrossrefCites:5,totalDimensionsCites:7,abstract:"Presently the additive technologies in manufacturing are widely developed in all industrialized countries. Replacing the traditional technology of casting and machining with additive technologies, one can significantly reduce material consumption and labor costs. They also allow obtaining products with desired properties. The most promising for manufacturing large-sized products is the additive technology of high-speed direct laser deposition. Using this technology allows to create complex parts and construction to one technological operation without using addition equipment and tools. This technology allows decreasing of consumption of raw materials and decrease amount of waste. Equipment for realization of DLD technology is universal and based on module design principle. DLD is based on layer-by-layer deposition and melting of powder by laser beam from using a sliced 3D computer-aided design (CAD) file. The materials used are powders based on Fe, Ni, and Ti. This chapter presents the results of machine design and research HS DLD technology from various materials.",book:{id:"6306",slug:"additive-manufacturing-of-high-performance-metals-and-alloys-modeling-and-optimization",title:"Additive Manufacturing of High-performance Metals and Alloys",fullTitle:"Additive Manufacturing of High-performance Metals and Alloys - Modeling and Optimization"},signatures:"Gleb Turichin and Olga Klimova-Korsmik",authors:[{id:"212068",title:"Dr.",name:null,middleName:null,surname:"Klimova-Korsmik",slug:"klimova-korsmik",fullName:"Klimova-Korsmik"}]}],mostDownloadedChaptersLast30Days:[{id:"72209",title:"Multifunctional Clay in Pharmaceuticals",slug:"multifunctional-clay-in-pharmaceuticals",totalDownloads:822,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Clay has its widespread applications in pharmaceuticals from ancient world to modern era. It is one of the excellent excipients present in the commercially available pharmaceuticals. Its use in many of dosage forms viz. in suspension, emulsion, ointments, gels, tablet and as drug delivery carrier as suspending agent, emulsifying agent, stiffening agent, binder, diluent, opacifier, and as release retardant have been explored in many studies. Variety of minerals is used as both excipient and as an active ingredient; among that kaolinite, talc, and gypsum are important. Their inertness, low toxicity, versatile physiochemical properties and cost effectiveness has increased its usage in pharma industries. Many minerals have its own pharmacological action as antacid, anti-bacterial, anti-emetic, anti- diarrheal agent and as skin protectant etc. Their unique structure which helps them to absorb material onto their layered sheets has opened a wide variety of applications in drug delivery. The understanding of surface chemistry and particle size distribution of clay minerals has led the pharmaceutical field in many directions and future perspectives.",book:{id:"9313",slug:"clay-science-and-technology",title:"Clay Science and Technology",fullTitle:"Clay Science and Technology"},signatures:"Nandakumar Selvasudha, Unnikrishnan-Meenakshi Dhanalekshmi, Sekar Krishnaraj, Yogeeswarakannan Harish Sundar, Nagarajan Sri Durga Devi and Irisappan Sarathchandiran",authors:[{id:"317602",title:"Ph.D.",name:"Nandakumar",middleName:null,surname:"Selvasudha",slug:"nandakumar-selvasudha",fullName:"Nandakumar Selvasudha"},{id:"319654",title:"Dr.",name:"Unnikrishnan-Meenakshi",middleName:null,surname:"Dhanalekshmi",slug:"unnikrishnan-meenakshi-dhanalekshmi",fullName:"Unnikrishnan-Meenakshi Dhanalekshmi"},{id:"319655",title:"Dr.",name:"Sekar",middleName:null,surname:"Krishnaraj",slug:"sekar-krishnaraj",fullName:"Sekar Krishnaraj"},{id:"319656",title:"Mr.",name:"Yogeeswarakannan Harish",middleName:null,surname:"Sundar",slug:"yogeeswarakannan-harish-sundar",fullName:"Yogeeswarakannan Harish Sundar"},{id:"319657",title:"Mrs.",name:"Nagarajan Sri",middleName:null,surname:"Sridurga Devi",slug:"nagarajan-sri-sridurga-devi",fullName:"Nagarajan Sri Sridurga Devi"},{id:"319658",title:"Dr.",name:"Irisappan",middleName:null,surname:"Sarathchandiran",slug:"irisappan-sarathchandiran",fullName:"Irisappan Sarathchandiran"}]},{id:"80125",title:"Perspective Chapter: Additive Manufactured Zirconia-Based Bio-Ceramics for Biomedical Applications",slug:"perspective-chapter-additive-manufactured-zirconia-based-bio-ceramics-for-biomedical-applications",totalDownloads:185,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Zirconia was established as one of the chief vital ceramic materials for its superior mechanical permanency and biocompatibility, which make it a popular material for dental and orthopedic applications. This has inspired biomedical engineers to exploit zirconia-based bioceramics for dental restorations and repair of load-bearing bone defects caused by cancer, arthritis, and trauma. Additive manufacturing (AM) is being promoted as a possible technique for mimicking the complex architecture of human tissues, and advancements reported in the recent past make it a suitable choice for clinical applications. AM is a bottom-up approach that can offer a high resolution to 3D printed zirconia-based bioceramics for implants, prostheses, and scaffold manufacturing. Substantial research has been initiated worldwide on a large scale for reformatting and optimizing zirconia bioceramics for biomedical applications to maximize the clinical potential of AM. This book chapter provides a comprehensive summary of zirconia-based bioceramics using AM techniques for biomedical applications and highlights the challenges related to AM of zirconia.",book:{id:"10974",slug:"advanced-additive-manufacturing",title:"Advanced Additive Manufacturing",fullTitle:"Advanced Additive Manufacturing"},signatures:"Sakthiabirami Kumaresan, Soundharrajan Vaiyapuri, Jin-Ho Kang, Nileshkumar Dubey, Geetha Manivasagam, Kwi-Dug Yun and Sang-Won Park",authors:[{id:"246235",title:"Prof.",name:"Geetha",middleName:null,surname:"Manivasagam",slug:"geetha-manivasagam",fullName:"Geetha Manivasagam"},{id:"426610",title:"Prof.",name:"Park",middleName:null,surname:"Sangwon",slug:"park-sangwon",fullName:"Park Sangwon"},{id:"429162",title:"Dr.",name:"Sakthiabirami",middleName:null,surname:"Kumaresan",slug:"sakthiabirami-kumaresan",fullName:"Sakthiabirami Kumaresan"},{id:"442019",title:"Dr.",name:"Soundharrajan",middleName:null,surname:"Vaiyapuri",slug:"soundharrajan-vaiyapuri",fullName:"Soundharrajan Vaiyapuri"},{id:"442021",title:"Dr.",name:"Jin-Ho",middleName:null,surname:"Kang",slug:"jin-ho-kang",fullName:"Jin-Ho Kang"},{id:"442023",title:"Prof.",name:"Nileshkumar",middleName:null,surname:"Dubey",slug:"nileshkumar-dubey",fullName:"Nileshkumar Dubey"},{id:"442024",title:"Prof.",name:"Kwi-Dug",middleName:null,surname:"Yun",slug:"kwi-dug-yun",fullName:"Kwi-Dug Yun"}]},{id:"72560",title:"Limestone Clays for Ceramic Industry",slug:"limestone-clays-for-ceramic-industry",totalDownloads:677,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Limestone clays are used in the ceramic segment in the manufacture of bricks, ceramic tiles, and in the production of cement, among others. Limestone can be present in soils in pure form or as a contaminant, but always from marine environments. The limestone after burning can present a high loss of mass (35–45%), which can cause serious problems with the sintering of ceramic products such as bricks, tiles. The calcium or magnesium carbonate once dissociated forms calcium oxide (CaO) and releases carbon dioxide (CO2). CaO in contact with water subsequently experiences very high expansions that can cause cracks in the materials. Researchers have studied procedures to inhibit limestone action on clays as well as to set the correct temperature for firing. In this chapter, examples of clays with different percentages of calcium carbonate (CaCO3) that are used in the ceramic segment and their characteristics will be given.",book:{id:"9313",slug:"clay-science-and-technology",title:"Clay Science and Technology",fullTitle:"Clay Science and Technology"},signatures:"Herbet Alves de Oliveira and Cochiran Pereira dos Santos",authors:[{id:"316552",title:"Dr.",name:"Herbet",middleName:null,surname:"Alves de Oliveira",slug:"herbet-alves-de-oliveira",fullName:"Herbet Alves de Oliveira"},{id:"320536",title:"Dr.",name:"Cochiran",middleName:null,surname:"Pereira dos Santos",slug:"cochiran-pereira-dos-santos",fullName:"Cochiran Pereira dos Santos"}]},{id:"60707",title:"Processing Parameters for Selective Laser Sintering or Melting of Oxide Ceramics",slug:"processing-parameters-for-selective-laser-sintering-or-melting-of-oxide-ceramics",totalDownloads:2092,totalCrossrefCites:7,totalDimensionsCites:12,abstract:"In this chapter, we present a detailed introduction to the factors which influence laser powder bed fusion (LPBF) on oxide ceramics. These factors can be in general divided in three main categories: laser-related factors (wavelength, power, scanning speed, hatch distance, scan pattern, beam diameter, etc.), powder- and material-related factors (flowability, size distribution, shape, powder deposition, thickness of deposited layers, etc.), and other factors (pre- or post-processing, inert gas atmosphere, etc.). The process parameters directly affect the amount of energy delivered to the surface of the thin layer and the energy density absorbed by the powders; therefore, decide the physical and mechanical properties of the built parts, such as relative density, porosity, surface roughness, dimensional accuracy, strength, etc. The parameter-property relation is hence reviewed for the most studied oxide ceramic materials, including families from alumina, silica, and some ceramic mixtures. Among those parameters, reducing temperature gradient which decreases the thermal stresses is one of the key factors to improve the ceramic quality. Although realizing crack-free ceramics combined with a smooth surface is still a major challenge, through optimizing the parameters, it is possible for LPBF processed ceramic parts to achieve properties close to those of conventionally produced ceramics.",book:{id:"6306",slug:"additive-manufacturing-of-high-performance-metals-and-alloys-modeling-and-optimization",title:"Additive Manufacturing of High-performance Metals and Alloys",fullTitle:"Additive Manufacturing of High-performance Metals and Alloys - Modeling and Optimization"},signatures:"Haidong Zhang and Saniya LeBlanc",authors:[{id:"213235",title:"Prof.",name:"Saniya",middleName:null,surname:"LeBlanc",slug:"saniya-leblanc",fullName:"Saniya LeBlanc"},{id:"213239",title:"Dr.",name:"Haidong",middleName:null,surname:"Zhang",slug:"haidong-zhang",fullName:"Haidong Zhang"}]},{id:"60683",title:"MPFEM Modeling on the Compaction of Al/SiC Composite Powders with Core/Shell Structure",slug:"mpfem-modeling-on-the-compaction-of-al-sic-composite-powders-with-core-shell-structure",totalDownloads:980,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Uniaxial die compaction of two-dimensional (2D) Al/SiC core/shell (core: SiC; shell: Al) composite powders with different initial packing structures was numerically reproduced using DEM-FEM coupled MPFEM modeling from particulate scale. The effects of external pressure, initial packing structure, and SiC content on the packing densification were systematically presented. Various macro and micro properties such as relative density and distribution, stress and distribution, particle rearrangement (e.g. sliding and rolling), deformation and mass transfer, and interfacial behavior within composite particles were characterized and analyzed. The results show that by properly controlling the initial packing structure, pressure, and SiC content, various anisotropic and isotropic Al/SiC particulate composites with high relative densities and uniform density/stress distributions can be obtained. At early stage of the compaction, the densification mechanism mainly lies in the particle rearrangement driven by the low interparticle forces. In addition to sliding, accompanied particle rolling also plays an important role. With the increase of the compaction pressure, the force network based on SiC cores leads to extrusion on Al shells between two cores, contributing to mass transfer and pore filling. During compaction, the debonding between the core and shell of each composite particle appears and then disappears gradually in the final compact.",book:{id:"6737",slug:"powder-technology",title:"Powder Technology",fullTitle:"Powder Technology"},signatures:"Xizhong An, Yu Liu, Fen Huang and Qian Jia",authors:[{id:"114055",title:"Prof.",name:"Xizhong",middleName:null,surname:"An",slug:"xizhong-an",fullName:"Xizhong An"},{id:"237739",title:"Mr.",name:"Yu",middleName:null,surname:"Liu",slug:"yu-liu",fullName:"Yu Liu"},{id:"237740",title:"Ms.",name:"Fen",middleName:null,surname:"Huang",slug:"fen-huang",fullName:"Fen Huang"},{id:"242885",title:"Ms.",name:"Qian",middleName:null,surname:"Jia",slug:"qian-jia",fullName:"Qian Jia"}]}],onlineFirstChaptersFilter:{topicId:"292",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82676",title:"Electrospinning of Fiber Matrices from Polyhydroxybutyrate for the Controlled Release Drug Delivery Systems",slug:"electrospinning-of-fiber-matrices-from-polyhydroxybutyrate-for-the-controlled-release-drug-delivery-",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.105786",abstract:"The submission provides an overview of current state of the problem and authors’ experimental data on manufacturing nonwoven fibrous matrices for the controlled release drug delivery systems (CRDDS). The choice of ultrathin fibers as effective carriers is determined by their characteristics and functional behavior, for example, such as a high specific surface area, anisotropy of some physicochemical characteristics, spatial limitations of segmental mobility that are inherent in nanosized objects, controlled biodegradation, and controlled diffusion transport. The structural-dynamic approach to the study of the morphology and diffusion properties of biopolymer fibers based on polyhydroxybutyrate (PHB) is considered from several angles. In the submission, the electrospinning (ES) application to reach specific characteristics of materials for controlled release drug delivery is discussed.",book:{id:"11127",title:"Electrospinning - Material Technology of the Future",coverURL:"https://cdn.intechopen.com/books/images_new/11127.jpg"},signatures:"Anatoly A. Olkhov, Svetlana G. Karpova, Anna V. Bychkova, Alexandre A. Vetcher and Alexey L. Iordanskii"},{id:"81249",title:"Electrospun Polymeric Substrates for Tissue Engineering: Viewpoints on Fabrication, Application, and Challenges",slug:"electrospun-polymeric-substrates-for-tissue-engineering-viewpoints-on-fabrication-application-and-ch",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.102596",abstract:"Electrospinning is the technique for producing nonwoven fibrous structures, to mimic the fabrication and function of the native extracellular matrix (ECM) in tissue. Prepared fibrous with this method can act as potential polymeric substrates for proliferation and differentiation of stem cells (with the cellular growth pattern similar to damaged tissue cells) and facilitation of artificial tissue remodeling. Moreover, such substrates can improve biological functions, and lead to a decrease in organ transplantation. In this chapter, we focus on the fundamental parameters and principles of the electrospinning technique to generate natural ECM-like substrates, in terms of structural and functional complexity. In the following, the application of these substrates in regenerating various tissues and the role of polymers (synthetic/natural) in the formation of such substrates is evaluated. Finally, challenges of this technique (such as cellular infiltration and inadequate mechanical strength) and solutions to overcome these limitations are studied.",book:{id:"11127",title:"Electrospinning - Material Technology of the Future",coverURL:"https://cdn.intechopen.com/books/images_new/11127.jpg"},signatures:"Azadeh Izadyari Aghmiuni, Arezoo Ghadi, Elmira Azmoun, Niloufar Kalantari, Iman Mohammadi and Hossein Hemati Kordmahaleh"},{id:"82145",title:"Slope Casting Process: A Review",slug:"slope-casting-process-a-review",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.102742",abstract:"Semi solid processing is a near net shape casting process and one of the promising techniques to obtain dendritic free structure of metals. Semi solid casting gives numerous advantages than solid processing and liquid processing. Semi solid casting process gives, Laminar flow filling of die without turbulence, Lower metal temperature, Less shrinkage, Less porosity, Higher mechanical properties. Semi solid casting process is industrially successful, producing a variety of products with good quality. Slope Casting process is a simple technique to produce semi solid feed-stoke with globular microstructure and dendrite free structure castings. Slope casting process depends on different process parameters like slope length, slope angle, pouring temperature etc. The present study mainly focuses on review of various explorations made by researchers with different process parameters of the Slope casting process and explain the mechanisms that lead to microstructural changes which leads to good mechanical properties.",book:{id:"11119",title:"Casting Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11119.jpg"},signatures:"Mukkollu Sambasiva Rao and Amitesh Kumar"},{id:"81611",title:"Biomass Electrospinning: Recycling Materials for Green Economy Applications",slug:"biomass-electrospinning-recycling-materials-for-green-economy-applications",totalDownloads:40,totalDimensionsCites:0,doi:"10.5772/intechopen.103096",abstract:"The development and advancement of electrospinning (ES) presents a unique material technology of the future achieved by fabricating novel nanofibrous materials with multifunctional physical (three-dimensional [3D] structure, nanoscalable sizes) and chemical characteristics (functional groups). Advancing the possibility of preparing various classes of novel organic and inorganic electrospun fiber composites with unique features such as polymer alloys, nanoparticles (NPs), active agents, and devices. This feature gives provision for internal access of the setup parameters such as polymer precursor material, polymer concentration, solvent, and the method of fiber collection that consequentially improves the intrinsic control of the construction mechanism of the final nanofibrous architecture. In synthetic electrospinning, the nanofibrous material processing allows for internal control of the electrospinning mechanism and foster chemical crosslinking to generate covalent connections between polymeric fibers. Comparing technologies according to materials of the future revealed that electrospinning supports the formation of micro-scale and in some cases nano-scale fibers while the formation of thin films is facilitated by the electrospraying system. Recent innovations point to various biomass waste streams that may be used as an alternative source of polymeric materials for application in electrospinning to produce materials for the future.",book:{id:"11127",title:"Electrospinning - Material Technology of the Future",coverURL:"https://cdn.intechopen.com/books/images_new/11127.jpg"},signatures:"Farai Dziike, Phylis Makurunje and Refilwe Matshitse"},{id:"81245",title:"Functional Nanofibers for Sensors",slug:"functional-nanofibers-for-sensors",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.102597",abstract:"Electrospun nanomaterials and their applications have increasingly gained interest over the last decade. Nanofibers are known for their exceptional surface area and wide opportunities for their functionalization. These properties have been attractive for various sensing applications; however, mostly electric sensing principles have been reported. An overview of most frequently studied concepts will be presented. A novel approach based on optical detection will be described. Various functionalized nanofiber materials have been used to demonstrate feasibility of realization of miniature sensors of biomedical and chemical values (enzymes reactions, metal ions content, concentration, etc.). Compactness and sensitivity of the sensors are significantly enhanced through original hybrid fiber-optic/nanofiber design. The potential of the new detection principle for various applications (bio-medical, chemical, forensic, automotive, etc.) will be discussed.",book:{id:"11127",title:"Electrospinning - Material Technology of the Future",coverURL:"https://cdn.intechopen.com/books/images_new/11127.jpg"},signatures:"Stanislav Petrík and Mayza Ibrahim"},{id:"80458",title:"Production of Nanofibers from Plant Extracts by Electrospinning Method",slug:"production-of-nanofibers-from-plant-extracts-by-electrospinning-method",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.102614",abstract:"The fact that different plants grow in each climate type, that each plant has different and many benefits, and that it can obtain bio-structured, sustainable, economic, and ecological products has increased the work of researchers in this field. The long-term toxicity and harmful side effects of herbal extracts are generally less compared to synthetic drugs. Studies on the production of nanofibrous membrane structures from plant extracts are relatively limited and are an emerging field. Herbal extracts have a positive effect in electrospinning applications with their biodiversity, ability to maintain biological functionality, and wound healing effects against pathogenic microorganisms. With the creation of nanofiber structures of plants obtained from natural sources, applications in fields such as wound healing, tissue engineering, drug release are increasing day by day.",book:{id:"11127",title:"Electrospinning - Material Technology of the Future",coverURL:"https://cdn.intechopen.com/books/images_new/11127.jpg"},signatures:"Nilşen Sünter Eroğlu"}],onlineFirstChaptersTotal:11},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"August 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA and her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. She is the Assistant Director of the SEARCH Center at UCR and is a faculty member in the Graduate Program in Neuroscience.",institutionString:null,institution:{name:"University of California, Riverside",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,annualVolume:null,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. 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He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. 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He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},onlineFirstChapters:{paginationCount:18,paginationItems:[{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella 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